1,503,786 results match your criteria Hormone and Metabolic Research[Journal]
Semin Neurol 2018 Dec 6;38(6):627-633. Epub 2018 Dec 6.
Department of Neurology, University at Buffalo School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York.
Headache is a neurologic disorder that displays gender dichotomy. It is well established that there is a strong link between migraine headache and sex hormones, specifically estrogen, which influences the severity of migraines during the menstrual cycle, pregnancy, and menopause. Furthermore, the epidemiology of headaches during pregnancy and the postpartum period is very distinct from that in males or nonpregnant females, in part due to the hemodynamic and hematologic changes that occur during pregnancy. Read More
Horm Res Paediatr 2018 Dec 6;90(4):1-7. Epub 2018 Dec 6.
Background: Despite the developments of recombinant growth hormone (rhGH) treatment and the benefits in long-term clinical health outcomes, evidence has shown that many children with growth hormone deficiency (GHD) still fail to achieve their target adult height. Suboptimal outcomes have been largely attributed to treatment non-adherence.
Methods: A search of 11 electronic databases was undertaken to identify relevant articles, published in English, between 1985 and 2018. Read More
Transl Oncol 2018 Dec 3;12(2):375-380. Epub 2018 Dec 3.
Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Magdeburger Str., 06097 Halle, Germany. Electronic address:
Objectives: Numerous studies investigated relationships between positron emission tomography and proliferation index Ki-67 in breast cancer (BC) with inconsistent results. The aim of the present analysis was to provide evident data about associations between standardized uptake value (SUV) and expression of Ki-67 in BC.
Methods: MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUV and Ki-67 in BC up to April 2018. Read More
Biomed Pharmacother 2018 Dec 3;110:302-311. Epub 2018 Dec 3.
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, PR China; Sichuan Neo-Green Pharmaceutical Technology Development Co., Ltd, Chengdu 610081, PR China. Electronic address:
Ethnopharmacological Relevance: Er Shen Wan (ESW), has been empirically used for treating spleen-kidney Yang deficiency (SKYD) syndrome in Traditional Chinese medicine (TCM) for centuries and shows a variety of activities. The medicinal formula is a mixture of two component herbs, Psoraleae Fructus (PF, Bu-Gu-Zhi in Chinese) and Myristicae Semen (MS, Rou-Dou-Kou in Chinese). The current study was designed to evaluate ESWP antidiuretic treatment of polyuria and to explore potential mechanisms of renal water metabolism in the rat model of SKYD-induced diarrhea. Read More
Psychoneuroendocrinology 2018 Nov 30;102:63-67. Epub 2018 Nov 30.
Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, D-54290, Trier, Germany. Electronic address:
Secretion of the stress hormone cortisol follows a circadian rhythm and is stimulated following stress exposure. Cortisol regulates the transcription of several genes, primarily through activation of the glucocorticoid receptor (GR). Previously, we showed an upregulation of PERIOD genes PER1 and PER3 after pharmacological/glucocorticoid challenge in vivo and in vitro. Read More
Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.
Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, Brazil,; Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;. Electronic address:
Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Read More
Life Sci 2018 Dec 3. Epub 2018 Dec 3.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:
Aims: Electro-acupuncture (EA) is frequently recommended as a complementary therapy for premature ovarian failure (POF) in the clinical. However, little information exists about its potential treatment mechanisms. The study was designed to observe the effect of EA to ovarian function and fertility in POF mice model, and investigated its potential mechanisms on PI3K/AKT/mTOR signaling pathway. Read More
Pharmacol Biochem Behav 2018 Dec 3. Epub 2018 Dec 3.
New York State Psychiatric Institute, New York, NY, United States of America; Columbia University Medical Center, New York, NY, United States of America.
Cannabis is the most widely used illicit drugs and the changing legal, political and cultural climate will likely increase cannabis use further. One factor that may underlie the transition from recreational use to problematic use is stress. The hormone oxytocin (OXT) modulates stress and may have therapeutic efficacy for substance use disorders, but few studies have examined OXT in cannabis users. Read More
Neurotoxicology 2018 Dec 3. Epub 2018 Dec 3.
Department of Biology, Neuroscience Program, University of Puget Sound, Tacoma, Washington, USA. Electronic address:
Gonadotropin releasing hormone (GnRH) neurons in the brain are the main controllers of reproduction and reproductive behavior in most vertebrates, and are susceptible to endocrine disruption by different bisphenols. While the endocrine disrupting properties of bisphenol A have been well documented, commonly used analogues such as bisphenol F (BPF) are not as well studied. In this study we examined the effects of early, low-dose, chronic BPF exposure on the development of the GnRH neural system in the zebrafish embryo. Read More
PLoS One 2018 6;13(12):e0208576. Epub 2018 Dec 6.
Department of Reproductive Medicine & Fertility Preservation, Hôpital Jean Verdier, Bondy, France.
In vitro maturation (IVM) of oocytes retrieved at germinal vesicle or Metaphase I stage, followed by vitrification of Metaphase II (MII) oocytes, has recently emerged as an option for urgent fertility preservation (FP). Priming is usually achieved with an injection of hCG, 10,000 IU, 36 hours before retrieval. This study aimed to assess a new method of priming, using GnRH agonists, and compare it to hCG, in cancer patients undergoing urgent FP. Read More
PLoS One 2018 6;13(12):e0208575. Epub 2018 Dec 6.
School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia.
Background: A key mechanism thought to underlie Posttraumatic Stress Disorder (PTSD) is enhanced emotional memory consolidation. Recent evidence in healthy controls revealed that women have greater negative memory consolidation following stress relative to men. This study examined emotional memory consolidation in women and men with PTSD, and in trauma-exposed and non-trauma controls to test the hypothesis that emotionally negative memory consolidation would be greater in women with PTSD. Read More
Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.
S Wang, Neurosurgery, Fuzhou General Hospital, Fuzhou, China., Fuzhou, China.
Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high energy metabolisms. Read More
Acta Med Port 2018 Nov 30;31(11):680-690. Epub 2018 Nov 30.
Unidade de Saúde Familiar S. Julião. Agrupamento de Centros de Saúde de Lisboa Ocidental e Oeiras. Lisboa. Portugal.
Introduction: Female sexual dysfunction is a common problem, affecting more than 1/3 of women during their lives. The aim of this review is to review the evidence for the effectiveness of testosterone in sexual dysfunction in postmenopausal women, particularly in the improvement of sexual desire.
Material And Methods: The authors searched in international databases National Guidelines Clearinghouse, Guidelines Finder, Cochrane Library and MEDLINE/PubMed, for guidelines, systematic reviews, meta-analysis and randomized controlled trials, published between January 2005 and February 2017, using the MeSH terms 'testosterone', 'androgens', 'libido', 'sexual dysfunctions' and 'menopause'. Read More
Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):424-428. Epub 2018 Nov 30.
Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico ISSEMyM Ecatepec, Servicio de Cirugía General. Ecatepec, Estado de México, México
Background: Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In all cases a genetic study must be performed, in order to find mutations in known genes, and after the resolution of the disease, based on the results, a contralateral prophylactic mastectomy should be considered. Read More
J Bone Miner Res 2018 Dec 12;33(12):2239-2241. Epub 2018 Nov 12.
Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.
Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.
Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?
Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.
What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More
JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.
Department of Medicine, Weill Cornell Medical College, New York, New York.
Importance: Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women. Whether excess adiposity is associated with increased risk in women with a normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is unknown.
Objective: To investigate the association between body fat and breast cancer risk in women with normal BMI. Read More
Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.
Department of Gynecology and Obstetrics, Regio Klinikum Pinneberg, Pinneberg, Germany.
Purpose Of Review: Cyclin-dependent kinases (CDK) are key regulatory enzymes that control cell cycle and cell division. In the recent years, new therapeutic options selectively targeting CDK 4 and 6 have shown promising clinical activity in several solid tumors. Since 2015, three CDK 4/6 inhibitors have been approved for treatment of hormone receptor-positive HER2-negative metastatic breast cancer: palbociclib, ribociclib and abemaciclib. Read More
Ugeskr Laeger 2018 Dec;180(49)
Acromegaly is a rare and disabling disease with a plethora of symptoms and signs attributed to sustained elevations and actions of growth hormone and insulin-like growth factor 1. Acromegaly is characterised by excessive somatic growth and multiple comorbidities in addition to occasional compression of the optic nerve and hypopituitarism due to the underlying adenoma. The course of the disease is insidious, and a diagnostic delay of 5-10 years is typical, and this pre-diagnostic period is also associated with increased morbidity. Read More
Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.
National Institutes of Health,Niddk.ddb, United States.
Rat pancreatic acinar cells possess only the p21-activated kinase (PAKs), PAK4 of the Group-II p21-activated kinase (PAK) and it is activated by gastrointestinal hormones/neurotransmitters stimulating PLC and by a number of growth factors. However, little is known generally of cAMP-agents causing PAK4 activation and there are no studies with gastrointestinal hormones/neurotransmitters activating cAMP cascades. In the present study, we examined the ability of VIP and secretin, which stimulate cAMP generation in pancreatic acini, to stimulate PAK4 activation, the signaling cascades involved and its possible role in activating Na+,K+ATPase. Read More
Am J Physiol Gastrointest Liver Physiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Clinical Physiology and Nuclear Medicine, Hvidovre University Hospital.
Dietary fat, and particularly fatty acids from hydrolyzed triglycerides, reduce appetite, whereas, paradoxically, a high-fat diet leads to excess calorie intake and weight gain. We therefore hypothesized that the appetite-regulating effects of dietary fat is perturbed in obesity. Ten men with severe obesity (median BMI 51. Read More
Asian J Androl 2018 Nov 30. Epub 2018 Nov 30.
Center for Reproductive Medicine, Shandong University, Jinan 250001, China.
The purpose of this study was to determine the diagnostic accuracy of serum inhibin B (INHB) as a predictor of the retrieval outcome of testicular haploid gametes (spermatids and testicular spermatozoa) in nonobstructive azoospermic men. Serum hormone levels, testicular volume, and histological evaluation were performed in 403 Chinese nonobstructive azoospermic men. Testicular haploid gamete was successfully retrieved in 213 of 403 patients (52. Read More
Endocr Metab Immune Disord Drug Targets 2018 Dec 6. Epub 2018 Dec 6.
Laboratorio de Hígado, Páncreas y Motilidad (HIPAM) - Unidad de Investigación en Medicina Experimental, Facultad de Medicina, UNAM. Mexico.
Background: Natural killer cells (NKC) are a major component of innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC. Read More
Diabetes Obes Metab 2018 Dec 5. Epub 2018 Dec 5.
Medical School, University of Western Australia, and Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Western Australia, Australia.
Background: Low circulating testosterone is associated with an increased risk of developing type 2 diabetes (T2DM) in overweight men with impaired glucose tolerance (IGT).
Aim: To determine in a multi-centre, double-blinded placebo-controlled randomised trial, whether testosterone treatment combined with lifestyle intervention (Weight Watchers®) relative to lifestyle intervention alone, reduces T2DM incidence and improves glucose tolerance at 2 years.
Study Population: Overweight or obese men aged 50-74 years with a serum testosterone of ≤14nmol/L and IGT or newly diagnosed T2DM established by an oral glucose tolerance test (OGTT). Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Gynecology, Linyi People's Hospital, Linyi, China.
Polycystic ovary syndrome (PCOS), known as a common endocrine disorder among females, plagues many PCOS patients. The current study aimed to explore the correlations of sex hormone-binding globulin (SHBG) polymorphisms with the outcome of in vitro fertilization-embryo transfer (IVF-ET) in PCOS patients. PCOS patients who underwent IVF-ET and patients with non-PCOS-related infertility were selected in the study. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.
Neoadjuvant chemotherapy (NAC) is the major preoperative treatment of breast cancer (BC) with negative human epidermal growth factor receptor 2 (HER2), and the efficacy of NAC and the optimization of regimen are under intensive research. The current study aimed to define the predictive biomarkers for paclitaxel (PTX) response in NAC of HER2-negative BC. Data from GSE25065, GSE26065, GSE41998, as well as drug sensitivity data of breast and ovarian cancer cell line from NCI60, were used. Read More
Langenbecks Arch Surg 2018 Dec 5. Epub 2018 Dec 5.
Section of Endocrine Surgery, Division of General Surgery, Department of Surgery, Medical University of Vienna, Waehringer Gürtel 18-20, A-1090, Vienna, Austria.
Purpose: Total parathyroidectomy (tPTX) in patients with renal hyperparathyroidism (RHPT) aims at the complete removal of all hyperfunctioning parathyroid tissue. Whenever parathyroidectomy is termed "total," undetectable postoperative parathyroid hormone (PTH) levels within the first postoperative week are expected. The aim of this study was to evaluate if tPTX is technically possible using a radical surgical procedure. Read More
Eur J Nucl Med Mol Imaging 2018 Dec 5. Epub 2018 Dec 5.
Department of Nuclear Medicine, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Hum Nat 2018 Dec 5. Epub 2018 Dec 5.
Department of Psychology, Oklahoma State University, Stillwater, OK, 74078-3064, USA.
The endogenous opioid system has received attention and extensive research for its effects on reward, pleasure, and pain. However, relative to other neurochemicals, such as oxytocin, vasopressin and dopamine, the function of opioids in regulating human attachment, sociosexuality, and other aspects of human sociality has not received much consideration. For example, nonapeptides (oxytocin and vasopressin) have been extensively studied in animals and humans for their possible roles in mother-offspring attachment, romantic attachment, fatherhood, and social cognition. Read More
Hormones (Athens) 2018 Dec 5. Epub 2018 Dec 5.
Department of Geriatric Medicine, Princess Royal University Hospital, King's College Hospital NHS Foundation Trust, 6B Durham Road, Bromley, London, BR2 0SG, UK.
There is today an exponential increase in prevalence of type 2 diabetes mellitus (T2DM), especially in young people. This downward shift in age of onset of T2DM has been shown by abundant evidence to be due to an increase in obesity among the young, the latter mainly attributable to unhealthy dietary habits and a sedentary lifestyle. It is therefore obvious that the prevention of diabetes rather its treatment is of is paramount importance. Read More
Plant Mol Biol 2018 Dec 5. Epub 2018 Dec 5.
College of Mechaincal and Electronic Engineering, Northwest A & F University, Yangling, 712100, Shaanxi, China.
Key Message: Shoot bending, as an effective agronomic measure, has been widely used to promote flowering in 'Fuji' apple trees. Here, we examined the transcriptional responses of genes in 'Fuji' apple buds at different flowering stages under a shoot-bending treatment using RNA sequencing. A complex genetic crosstalk-regulated network, involving abscisic acid-related genes, starch metabolism and circadian rhythm-related genes, as well as stress response-related genes, was up-regulated by shoot bending, in which were contrbuted to apple flower bud formation in response to shoot-bending conditions. Read More
Mol Biol Rep 2018 Dec 5. Epub 2018 Dec 5.
Laboratory of Biotechnology, School of Applied Sciences, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
The hormone insulin plays a central role in the metabolism of carbohydrates, lipids, and proteins. In relation to protein metabolism, insulin stimulates amino acid uptake and activates protein synthesis in responsive cells by modulation of signal transduction pathways, such as associated to Akt/PkB, mTOR, S6Ks, 4E-BP1, and several translation initiation/elongation factors. In this context, there is no information on direct cellular treatment with insulin and effects on eukaryotic translation initiation factor 5A (eIF5A) regulation. Read More
Immunol Res 2018 Dec 6. Epub 2018 Dec 6.
Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, 32 Turan Avenue, Astana, 010000, Kazakhstan.
The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10-17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). Read More
J Endocr Soc 2018 Dec 15;2(12):1345-1356. Epub 2018 Oct 15.
University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Context: Recombinant human FSH (r-hFSH), given to prepubertal boys with hypogonadotropic hypogonadism (HH), may induce Sertoli cell proliferation and thereby increase sperm-producing capacity later in life.
Objective: To evaluate the effects of r-hFSH, human chorionic gonadotropin (hCG), and testosterone (T) in such patients.
Design And Setting: Retrospective review in three tertiary centers in Finland between 2006 and 2016. Read More
Heliyon 2018 Nov 22;4(11):e00936. Epub 2018 Nov 22.
King Abdullah University of Science and Technology (KAUST), BESE Division, The BioActives Lab, Thuwal, 23955-6900, Saudi Arabia.
Strigolactones (SLs), a novel class of plant hormones, are key regulator of plant architecture and mediator of biotic interactions in the rhizosphere. Root-released SLs initiate the establishment of arbuscular mycorrhizal (AM) symbiosis by inducing spore germination and hyphal branching in AM fungi (AMF). However, these compounds also trigger the germination of root parasitic weeds, paving the way for deleterious infestation. Read More
Gynecol Oncol Rep 2019 Feb 16;27:1-4. Epub 2018 Nov 16.
Department of Gynecologic Oncology and Reproductive Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX, United States.
Objective: Up to 87% of uterine leiomyosarcomas have estrogen receptor positivity. There are no effective adjuvant therapies for LMS. The objective of this study was to determine the efficacy of letrozole in patients with newly diagnosed uterine leiomyosarcoma (uLMS). Read More
Evodevo 2018 1;9:23. Epub 2018 Dec 1.
1Institute of Biology, University of Graz, Universitätsplatz 2, 8010 Graz, Austria.
Background: Egg size represents an important form of maternal effect determined by a complex interplay of long-term adaptation and short-term plasticity balancing egg size with brood size. Haplochromine cichlids are maternal mouthbrooders showing differential parental investment in different species, manifested in great variation in egg size, brood size and duration of maternal care. Little is known about maternally determined molecular characters of eggs in fishes and their relation to egg size and trophic specialization. Read More
J Clin Aesthet Dermatol 2018 Oct 1;11(10):40-43. Epub 2018 Oct 1.
Drs. Platsidaki, Vasalou, Gerodimou, Markantoni, Kouris, Gregoriou, Rigopoulos, and Kontochristopoulos are with the Department of Dermatology and Venereology at Andreas Sygros Skin Hospital in Athens, Greece.
Skin tags (STs) are benign skin lesions. Their definite etiology remains unknown. We aim to examine the association of obesity, diabetes mellitus, hyperlipidemia, thyroid abnormalities, acanthosis nigricans, and multiple STs in a Greek primary population. Read More
J Cancer 2018 11;9(23):4536-4546. Epub 2018 Nov 11.
Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL.
: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy treatment. Previously, we showed that stearidonic acid (SDA), an omega-3 fatty acid, enhances the cytotoxicity of doxorubicin (DOX) in human PCa cells. Read More
J Cancer 2018 27;9(23):4422-4429. Epub 2018 Oct 27.
Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University School of Public Health, Graduate School of Medicine, Sendai, Japan.
Age at first birth has been increasing among women in developed countries. Meanwhile, endometrial cancer has also been increasing worldwide, being one of the most common female hormone-related cancers. The purpose of this study was to examine the association between age at first birth and the risk of endometrial cancer among Japanese women, and to examine the hypothesis that the recent increase in endometrial cancer incidence can be partly explained by the trend for increasing age at first birth. Read More
Thyroid Res 2018 30;11:17. Epub 2018 Nov 30.
6Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
Objectives: Thyroid malignancy constitutes the sixth common cancer type in the United Arab Emirates (UAE). There are no epidemiological data outlining the prevalence of cancer in thyroid nodules, nor previous analysis of ultra-sonographic features correlating with thyroid malignancy in the UAE. This study aimed to estimate the prevalence of thyroid malignancy in patients with thyroid nodules and to describe the ultra-sonographic characteristics of thyroid nodules harbouring malignancy. Read More
Infect Agent Cancer 2018 29;13:38. Epub 2018 Nov 29.
1Department of Surgery, Medical School, University of Pécs, Hungary, Ifjuság Street 13, Pécs, 7624 Hungary.
Background: The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patterns of the pre-treatment tumor biopsies with the HPV status and with the oncological response.
Methods: Pre-treatment tumor biopsies of 74 patients with locally advanced esophageal squamous cell carcinoma were processed retrospectively. Read More
Front Integr Neurosci 2018 21;12:57. Epub 2018 Nov 21.
The John B. Pierce Laboratory, Yale University, New Haven, CT, United States.
In most species, including humans, food preference is primarily controlled by nutrient value. In particular, glucose-containing sugars exert exquisitely strong effects on food choice via gut-generated signals. However, the identity of the visceral signals underlying glucose's rewarding effects remains uncertain. Read More