630,406 results match your criteria Hormone Therapy


Revived Attention for Adult Craniopharyngioma.

Exp Clin Endocrinol Diabetes 2020 Aug 4. Epub 2020 Aug 4.

Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Craniopharyngioma as a rare tumor originating from cells of rathke's pouch and representing 2-5% of all intracranial tumors is a rare and generally benign neoplasm of the central nervous system with two incidence peaks one in childhood and one after 40 years of age. Data on adult patients is scarce compared to childhood onset tumors, however the burden of disease caused by the tumors and related treatment options is significant. Clinical symptoms range from headaches, visual disability, cranial nerve affection or hypothalamic symptoms (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1217-7282DOI Listing

Molecular trait of follicular-patterned thyroid neoplasms defined by MALDI-imaging.

Biochim Biophys Acta Proteins Proteom 2020 Aug 1:140511. Epub 2020 Aug 1.

Department of Medicine and surgery, UNIMIB, Pathology, Monza, Italy. Electronic address:

In the field of thyroid neoplasms, the most interesting recent change regards the introduction of a new terminology for follicular-patterned thyroid tumors, named Noninvasive Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP). This pre-malignant tumor is considered to be the putative precursor of invasive carcinomas. However, given that several issues are still unresolved, the application of ancillary tools, based on omics-techniques, may improve the clinical management of these challenging cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbapap.2020.140511DOI Listing

Clinical Factors Affecting the Therapeutic Efficacy of Evening Primrose Oil on Mastalgia.

Ann Surg Oncol 2020 Aug 3. Epub 2020 Aug 3.

Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA.

Background: Saturated fatty acid esters may cause mastalgia via hypersensitivity of breast epithelium to circulating hormones. Evening primrose oil (EPO) may restore the saturated/unsaturated fatty acid balance and decrease sensitivity to steroidal hormones or prolactin. Conflicting results exist regarding EPO treatment for mastalgia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-020-08949-xDOI Listing

Hormone replacement therapy for open heart surgery in a patient with panhypopituitarism and diabetes insipidus.

Interact Cardiovasc Thorac Surg 2020 Aug 4. Epub 2020 Aug 4.

Department of Cardiovascular Surgery, Clinical Research Institute, National Hospital Organization, Kyushu Medical Center, Fukuoka, Japan.

We present an unusual case of a patient with panhypopituitarism and diabetes insipidus who underwent aortic valve replacement. We successfully managed these complicated endocrine disorders by using appropriate hormonal replacement therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/icvts/ivaa112DOI Listing

Disseminated cryptococcosis in a patient with adrenocortical carcinoma and Cushing's syndrome.

J Infect Chemother 2020 Jul 31. Epub 2020 Jul 31.

Department of Internal Medicine, Suwa Central Hospital, 4300 Tamagawa, Chino, Nagano, 391-8503, Japan. Electronic address:

Corticosteroids have been used for the treatment of a great variety of diseases. Therefore, the relationship between high doses of cortisol and infections has been widely known and prophylactic therapy has been established. Adrenocortical carcinoma is a rare malignancy with poor prognosis, so little is known about how to deal with the complications resulting from hormone excess such as Cushing's syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2020.07.008DOI Listing

Efficacy and safety of a low-dose continuous combined hormone replacement therapy with 0.5 mg 17β-estradiol and 2.5 mg dydrogesterone in subgroups of postmenopausal women with vasomotor symptoms.

Maturitas 2020 Sep 16;139:20-26. Epub 2020 May 16.

National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London SW3 6NP, UK. Electronic address:

Objectives: Various combinations of estrogens and progestogens are available for menopausal hormone therapy that differ in their efficacy and safety profile. We evaluated the efficacy and long-term safety of low-dose estradiol (0.5 mg) / dydrogesterone (2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.maturitas.2020.05.002DOI Listing
September 2020

Clinicopathologic Characteristics and Causes of Postmenopausal Bleeding in Older Patients.

Ann Geriatr Med Res 2018 Dec 31;22(4):189-193. Epub 2018 Dec 31.

Department of Occupational and Environmental Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University, Changwon, Korea.

Background: This study aimed to reveal the clinicopathologic features and causes of bleeding in older patients with postmenopausal bleeding (PMB) and to investigate the correlation between the ultrasonographic findings and etiology of PMB.

Methods: We retrospectively analyzed the causes and clinical characteristics of PMB in 498 patients who were diagnosed between January 2007 and December 2017. The population with PMB was divided into 2 groups according to age: Group A (n=204) included individuals more than 65 years of age and group B (n=294) included those less than 65 years of age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4235/agmr.18.0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387628PMC
December 2018

Late-onset thyrotoxicosis after the cessation of amiodarone.

Indian Pacing Electrophysiol J 2020 Jul 31. Epub 2020 Jul 31.

Centre for Heart Rhythm Disorders (CHRD), University of Adelaide, Australia; Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia. Electronic address:

Introduction: Amiodarone is a highly effective antiarrhythmic-drug with well recognized toxic side-effects. The effects of the drug late in patients with atrial fibrillation (AF) is not well described.

Methods And Results: We present a single centre prospectively collected series of patients with thyrotoxicosis occurring late after the cessation of amiodarone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ipej.2020.07.006DOI Listing

Cytochrome P450-mediated estrogen catabolism therapeutic avenues in epilepsy.

Acta Neurol Belg 2020 Aug 2. Epub 2020 Aug 2.

Department of Biological Science, Faculty of Science and Engineering, Health Research Institute, University of Limerick, Limerick, V94 T9PX, Ireland.

Epilepsy is a neuropsychiatric disorder, which does not have any identifiable cause. However, experimental and clinical results have asserted that the sex hormone estrogen level and endocrine system function influence the seizure and epileptic episodes. There are available drugs to control epilepsy, which passes through the metabolism process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13760-020-01454-8DOI Listing

The Impact of Hormonal Imbalances Associated with Obesity on the Incidence of Endometrial Cancer in Postmenopausal Women.

J Cancer 2020 11;11(18):5456-5465. Epub 2020 Jul 11.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

Obesity has long been associated with endometrial cancer amongst postmenopausal women; in fact, obese women are more than twice as likely to develop endometrial cancer as women of normal weight. The risk of developing this type of cancer increases with weight gains in adulthood, especially among women who did not use hormonal therapy for menopause. Thus, with an association between menopause, obesity, and endometrial cancer established, it prompts the following question: what specific factors could cause higher risk levels for endometrial cancer in this cohort of women? In this paper, the factor of hormonal changes and imbalances associated with both obesity and menopause will be examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jca.47580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391192PMC

Association of endocrine therapy with overall survival in women with hormone receptor-positive, HER2-negative, node-negative breast cancer of favorable histology.

Breast J 2020 Aug 1. Epub 2020 Aug 1.

Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Breast carcinomas are histologically diverse and have distinct prognostic significance. Early-stage breast cancers with favorable histopathologic features are managed comprehensively including adjuvant endocrine therapy at the discretion of clinicians. Using a de-identified large national cancer registry, we evaluated the overall survival benefit of endocrine therapy in patients diagnosed with HR-positive, HER2-negative, pT1-2N0 (tumor size < 3 cm), non-high-grade breast cancer with favorable histologies including tubular, mucinous, and cribriform types. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tbj.13995DOI Listing

Use of neoadjuvant versus adjuvant chemotherapy for hormone receptor-positive breast cancer: a National Cancer Database (NCDB) study.

Breast Cancer Res Treat 2020 Aug 1. Epub 2020 Aug 1.

Mount Sinai Health System, New York, USA.

Introduction: Neoadjuvant chemotherapy (NAC) is a well-established therapeutic option for patients with locally advanced disease often allowing downstaging and facilitation of breast conserving therapy. With evolution of better targeted treatment regimens and awareness of improved outcomes for significant responders, use of NAC has expanded particularly for triple negative and HER2-positive (HER2+) breast cancer. In this study, we explore utility of neoadjuvant chemotherapy for hormone receptor-positive HER2-negative (HR+ HER2-) patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-020-05809-wDOI Listing

Behavioral assessment of females with congenital adrenal hyperplasia.

Hormones (Athens) 2020 Aug 1. Epub 2020 Aug 1.

Department of Neurology and Psychiatry, Assiut University Hospital, P. O. Box 71516, Assiut, Egypt.

Purpose: Patients with congenital adrenal hyperplasia (CAH) have an increased risk of psychological/psychiatric symptoms and disorders. This study aimed to assess the behavior of girls with CAH and its independent risk variables.

Methods: This cross-sectional study included 55 girls with CAH due to 21-hydroxylase deficiency (mean age 12. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42000-020-00232-8DOI Listing

Meta-analysis of metabolic changes in children with idiopathic growth hormone deficiency after recombinant human growth hormone replacement therapy.

Endocrine 2020 Aug 1. Epub 2020 Aug 1.

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.

Purposes: We aimed to assess the effects of recombinant human growth hormone (rhGH) replacement therapy on metabolic changes by synthesizing data from clinical trials involving children with idiopathic growth hormone deficiency (IGHD).

Methods: Two investigators independently completed literature search, quality assessment, and data extraction. Effect-size estimates are expressed as weighted mean difference (WMD) with 95% confidence interval (CI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12020-020-02435-wDOI Listing

Prosigna® breast cancer assay: histopathologic correlation, development, and assessment of size, nodal status, Ki-67 (SiNK™) index for breast cancer prognosis.

Mod Pathol 2020 Aug 1. Epub 2020 Aug 1.

Department of Pathology, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.

The Prosigna® assay is a United States Food and Drug Administration (US-FDA) cleared molecular test for prognostic use in hormone receptor-positive stage I/II breast cancer in postmenopausal women. We analyzed histopathologic features of 79 cases with Prosigna® assay results and found a significant correlation between tumor size, grade, and Ki-67 labeling index with Prosigna® score (0-40, 41-60, and 61-100) and Prosigna® risk categories. Since the Prosigna® risk stratification is influenced by lymph node status, we designed an index that included lymph node status and the two most correlated variables (size and Ki-67 labeling index). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41379-020-0643-8DOI Listing

Venous thromboembolism in the hormonal milieu.

Curr Opin Hematol 2020 Sep;27(5):327-332

Hematology Division, Department of Medicine, Brigham and Women's Hospital.

Purpose Of Review: Hormonal therapy is administered for multiple indications including contraception, alleviation of menopausal symptoms, hypogonadism, and more recently, gender-affirming care. Data suggest varying degrees of increased risk for venous thromboembolism (VTE).

Recent Findings: While oral progestin only methods do not appear to increase the risk of VTE, an association was seen with injection progestin contraception. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOH.0000000000000599DOI Listing
September 2020

Non-hormonal mediators of uterine fibroid growth.

Curr Opin Obstet Gynecol 2020 Jul 27. Epub 2020 Jul 27.

Department of Surgery.

Purpose Of Review: Uterine fibroids are the most common benign neoplasms of the female reproductive tract and one of the major public health concerns. Although most women with uterine fibroids are asymptomatic, over 30% of them will present with varying symptoms. This review focuses on the role of non-hormonal mediators and pathways in uterine fibroid biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GCO.0000000000000650DOI Listing

Adherence and long-term outcomes of therapy in paediatric patients in Greece using the easypod™ electromechanical device for growth hormone treatment: The phase IV multicentre easypod™ connect observational study (ECOS).

Growth Horm IGF Res 2020 Jul 18;53-54:101336. Epub 2020 Jul 18.

Department of Endocrinology - Growth and Development, P. & A. Kyriakou Children's Hospital, Athens, Greece.

Background: The easypod™ injection device allows automatic recording and transmission of adherence data from patients receiving recombinant human growth hormone (rhGH [Saizen®]) to treat growth disorders. This analysis aimed to evaluate the adherence of Saizen® administered via easypod™ in a cohort of Greek patients from the easypod™ connect observational study (ECOS).

Methods: The phase IV, open-label, multicentre, observational, and longitudinal ECOS study (EMR200104-520, NCT01363674) enrolled patients treated for a minimum of 6 months and up to 3 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ghir.2020.101336DOI Listing

Activation of estrogen receptor α (ERα) is required for Alisol B23-acetate to prevent post-menopausal atherosclerosis and reduced lipid accumulation.

Life Sci 2020 Jul 30:118030. Epub 2020 Jul 30.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

The risk of atherosclerosis (AS) ascends among post-menopausal women, while current hormone replacement therapy exerts several adverse effects. Alisol B 23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, was reported to show multiple physiological activities, including regulating lipid metabolism. According to molecular docking analysis, it was predicted to bind with estrogen receptor α (ERα). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2020.118030DOI Listing
July 2020
2.702 Impact Factor

Regional improvements in lumbosacropelvic Hounsfield units following teriparatide treatment.

Neurosurg Focus 2020 Aug;49(2):E11

Departments of1Neurologic Surgery.

Objective: Opportunistic Hounsfield unit (HU) determination from CT imaging has been increasingly used to estimate bone mineral density (BMD) in conjunction with assessments from dual energy x-ray absorptiometry (DXA). The authors sought to compare the effect of teriparatide on HUs across different regions in the pelvis, sacrum, and lumbar spine, as a surrogate measure for the effects of teriparatide on lumbosacropelvic instrumentation.

Methods: A single-institution retrospective review of patients who had been treated with at least 6 months of teriparatide was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3171/2020.5.FOCUS20273DOI Listing

Tumor mutational burden related classifier is predictive of response to PD-L1 blockade in locally advanced and metastatic urothelial carcinoma.

Int Immunopharmacol 2020 Jul 29;87:106818. Epub 2020 Jul 29.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China; Medical Research Institute, Wuhan University, Wuhan, China; Research Center of Wuhan for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China. Electronic address:

Background: Immunotherapy has made encouraging progress in the treatment of urothelial carcinoma, but only a small percentage of patients respond effectively to the immune checkpoint blockade (ICB). Our study aims to develop a classifier could effectively predict the response to ICB.

Methods: Support vector machines recursive feature elimination (SVM-RFE) algorithm was used to feature selection, then compared nine common binary classification algorithms through machine learning, we selected the classifier with the highest prediction performance (LASSO logistics classifier). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.intimp.2020.106818DOI Listing

Influence of growth hormone therapy on the occurrence of second neoplasms in survivors of childhood cancer.

Eur J Endocrinol 2020 Jul 1. Epub 2020 Jul 1.

F de Vathaire, Research - B2M, Gustave Roussy, Villejuif, 94800, France.

Context: Growth hormone (GH) deficiency is a common late effect of cranial irradiation. However, concerns have been raised that GH treatment might lead to an increased risk of second neoplasm (SN).

Objective: To study the impact of GH treatment on the risk of SN in a French cohort of survivors of childhood cancer (CCS) treated before 1986. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-20-0369DOI Listing

Phase 3 trial of a small volume subcutaneous 6-month duration leuprolide acetate treatment for central precocious puberty.

J Clin Endocrinol Metab 2020 Aug 1. Epub 2020 Aug 1.

Nemours Children's Health System, Jacksonville FL, USA.

Context: Gonadotropin releasing hormone agonists (GnRHa) are standard of care for central precocious puberty (CPP). A 6-month subcutaneous injection has recently been approved by Food and Drug Administration.

Objective: Determine efficacy, pharmacokinetics and safety of 6-month 45 mg subcutaneous leuprolide acetate for CPP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgaa479DOI Listing

5-Year Estimated Glomerular Filtration Rate in Patients with Hypoparathyroidism Treated with and Without rhPTH(1-84).

J Clin Endocrinol Metab 2020 Aug 1. Epub 2020 Aug 1.

Columbia University College of Physicians and Surgeons, New York, NY, USA.

Context: Chronic hypoparathyroidism (HypoPT) is conventionally managed with oral calcium and active vitamin D. Recombinant human parathyroid hormone (1-84) (rhPTH[1-84]) is a therapy targeting the pathophysiology of HypoPT by replacing parathyroid hormone.

Objective: To compare changes in the estimated glomerular filtration rate (eGFR) in patients with chronic HypoPT receiving or not receiving rhPTH(1-84) during a 5-year period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/clinem/dgaa490DOI Listing

Very Low Levels of Serum Anti-Müllerian Hormone as a Possible Marker for Follicle Growth in Patients with Primary Ovarian Insufficiency Under Hormone Replacement Therapy.

Reprod Sci 2020 Jul 31. Epub 2020 Jul 31.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Patients with primary ovarian insufficiency (POI) occasionally present with follicle growth; however, accurately predicting cycles accompanied by follicle growth is challenging. Early-stage follicles produce serum anti-Müllerian hormone (AMH), a useful marker of ovarian reserve. Therefore, serum AMH levels indicate growth of small follicles (which are difficult to detect ultrasonographically) and may predict follicle growth in patients with POI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s43032-020-00278-4DOI Listing

Cardiac biomarkers in patients with prostate cancer and cardiovascular disease receiving gonadotrophin releasing hormone agonist vs antagonist.

Prostate Cancer Prostatic Dis 2020 Jul 31. Epub 2020 Jul 31.

Davidoff Cancer Centre, Rabin Medical Center, Petach Tikva, Israel.

Background: Gonadotrophin releasing hormone (GnRH) agonists and antagonists reduce testosterone levels for the treatment of advanced and metastatic prostate cancer. Androgen deprivation therapy (ADT) is associated with increased risk of cardiovascular (CV) events and CV disease (CVD), especially in patients with preexisting CVD treated with GnRH agonists. Here, we investigated the potential relationship between serum levels of the cardiac biomarkers N-terminal pro-B-type natriuretic peptide (NTproBNP), D-dimer, C-reactive protein (CRP), and high-sensitivity troponin (hsTn) and the risk of new CV events in prostate cancer patients with a history of CVD receiving a GnRH agonist or antagonist. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41391-020-0264-9DOI Listing

Conversion of Fibroblast into Functional Leydig-like Cell Using Defined Small Molecules.

Stem Cell Reports 2020 Jul 15. Epub 2020 Jul 15.

Department of Cell Biology, Jinan University, Guangzhou 510632, China; Department of Pharmacology, Jinan University, Guangzhou 510632, China; Guangdong Province Key Laboratory of Bioengineering Medicine of, Guangzhou 510632, China. Electronic address:

Recent studies have demonstrated that fibroblasts can be directly converted into functional Leydig cells by transcription factors. However, the transgenic approach used in these studies raises safety concerns for its future application. Here, we report that fibroblasts can be directly reprogrammed into Leydig-like cells by exposure to a combination of forskolin, 20α-hydroxycholesterol, luteinizing hormone, and SB431542. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2020.07.002DOI Listing

Adding carboplatin to chemotherapy regimens for metastatic castrate-resistant prostate cancer in postsecond generation hormone therapy setting: Impact on treatment response and survival outcomes.

Prostate 2020 Jul 31. Epub 2020 Jul 31.

Department of Urology, Mayo Clinic, Rochester, Minnesota.

Background: The clinical course in metastatic castrate-resistant prostate cancer (mCRPC) can be complicated when patients have disease progression after prior treatment with second generation hormone therapy (second HT), such as enzalutamide or abiraterone. Currently, limited data exist regarding the optimal choice of chemotherapy for mCRPC after failing second generation hormone therapy. We sought to evaluate three common chemotherapy regimens in this setting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pros.24048DOI Listing

Biochemical follow up of non-functioning benign thyroid nodules.

Clin Endocrinol (Oxf) 2020 Jul 31. Epub 2020 Jul 31.

University of Maryland School of Medicine, Division of Endocrinology, Diabetes, & Nutrition Department of Medicine, 827 Linden Avenue, Floor 2 South, Baltimore, MD, 21201, United States.

Objective: For the biochemical follow up of benign thyroid nodules, some authors recommend periodic life-long measurement of thyroid stimulating hormone (TSH) to assess for the development of toxic nodules over time. The purpose of this retrospective study was to assess the incidence of thyroid dysfunction over time in patients with benign thyroid nodule(s), with a normal TSH at diagnosis and to identify any factors that may predict biochemical dysfunction over time.

Methods: Medical records of patients with the diagnosis of thyroid nodule(s) between January 2011 to August 2014 were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.14303DOI Listing

Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate.

Horm Mol Biol Clin Investig 2020 Jul 31. Epub 2020 Jul 31.

Division for Obstetrics and Gynecology, Department of Children's and Women's Health, Karolinska Institutet, Karolinska University Hospital, SE-171 76, Stockholm, Sweden.

Background The impact of hormones on the development of breast cancer is despite extensive studies, incompletely understood. Combined estrogen-progestogen treatment augments the risk for breast cancer beyond that of estrogen alone, according to numerous studies. The role of breast cell proliferation as a promoter in the development and growth of breast cancer is well recognized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/hmbci-2019-0051DOI Listing

Osteoblast-n-Osteoclast: Making headway to osteoporosis treatment.

Curr Drug Targets 2020 Jul 31. Epub 2020 Jul 31.

Chitkara College of Pharmacy, Chitkara University, Punjab. India.

Background: Bone is a dynamic tissue that continuously undergoes the modeling and remodeling process to maintain its strength and firmness. Bone remodeling is determined by functioning of osteoblast and osteoclast cells activity. The imbalance between functioning of osteoclast and osteoblast cells leads to osteoporosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1389450121666200731173522DOI Listing

Age moderates the associations between TRAbs, free T3, and outcomes of Graves's disease patients with radioactive iodine treatment.

Clin Endocrinol (Oxf) 2020 Jul 30. Epub 2020 Jul 30.

Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective: This study aimed to explore whether age moderates the associations between TSH-receptor antibodies (TRAbs) with thyroid hormones and remission in patients with Graves' disease (GD) who undergo radioactive iodine (RAI) treatment.

Design: A single-centre retrospective study.

Patients: A total of 435 eligible consecutive patients diagnosed with GD, treated with RAI therapy were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cen.14301DOI Listing

SGLT2 Inhibitor-Induced Euglycemic Diabetic Ketoacidosis: A Case Report.

Kidney Med 2020 Mar-Apr;2(2):218-221. Epub 2020 Feb 22.

Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.

Euglycemic diabetic ketoacidosis is a rare but serious adverse effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors. We present a case of a woman in her 40s with type 2 diabetes mellitus hospitalized for revascularization for moyamoya disease who developed empagliflozin-associated euglycemic diabetic ketoacidosis despite having stopped the medication before admission. Surgical stress, acute postoperative illness, and decreased carbohydrate intake are postulated to be contributing factors to the development of ketosis in this patient, while near-normal glucose levels initially suggested nondiabetic ketoacidosis physiology and led to delayed diagnosis and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xkme.2019.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380362PMC
February 2020

Isolated Mesenteric Calciphylaxis With Ischemic Colitis in a Hemodialysis Patient Without Active Cutaneous Calciphylaxis: A Case Report of Calcific Uremic Arteriolopathy.

Kidney Med 2020 Mar-Apr;2(2):209-212. Epub 2020 Feb 22.

Renal Unit, Flinders Medical Centre, South Australia, Australia.

Calciphylaxis, also known as calcific uremic arteriolopathy, is a devastating systemic disease most commonly associated with chronic kidney failure. Its hallmark histopathologic features of small-vessel calcification, intimal hyperplasia, and microthrombi lead to microvascular occlusion and tissue necrosis. Clinically, it typically presents with painful cutaneous lesions that may be distal or proximal, with proximal lesions associated with higher mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xkme.2019.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380420PMC
February 2020

Short- and Long-term Effects of Dialysate Calcium Concentrations on Mineral and Bone Metabolism in Hemodialysis Patients: The K4 Study.

Kidney Med 2019 Sep-Oct;1(5):296-306. Epub 2019 Sep 11.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Rationale & Objective: The short- and long-term impact of conversion of dialysate calcium concentration from either 2.5 or 3.0 mEq/L to 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xkme.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380384PMC
September 2019

MORE THAN MEETS THE EYE IN A PATIENT WITH PCOS: ANDROGEN-SECRETING GRANULOSA CELL OVARIAN TUMOR IN A VIRILIZED WOMAN WITH POLYCYSTIC OVARIAN SYNDROME (PCOS).

AACE Clin Case Rep 2020 Jul-Aug;6(4):e170-e173. Epub 2020 Apr 3.

Objective: Granulosa cell ovarian tumors are known to secrete estrogen. Herein we report a patient presenting with primary amenorrhea and virilization with markedly high androgen levels, all thought to be disproportional to be attributed to polycystic ovary syndrome (PCOS) alone. Bilateral oophorectomy revealed a rare androgen-secreting granulosa cell ovarian tumor and bilateral cysts (PCOS) both contributing to manifestations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4158/ACCR-2019-0576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388264PMC

Free Thyroxine Concentrations Moderate the Response to a Cognitive Remediation Therapy in People With Early Psychosis: A Pilot Randomized Clinical Trial.

Front Psychiatry 2020 7;11:636. Epub 2020 Jul 7.

Department of Mental Health, Institut d'Investigació i Innovació Parc Taulí (I3PT), Parc Taulí Hospital Universitari, Sabadell, Spain.

Introduction: Cognitive deficits are a cause of functional disability in psychotic disorders. Cognitive remediation therapy (CRT) might be applied to improve these deficits. We conducted a pilot study to explore whether thyroid hormones might predict the response to CRT in patients with recent-onset psychosis (ROP). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2020.00636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358368PMC

Percutaneous CO2 Treatment Accelerates Bone Generation During Distraction Osteogenesis in Rabbits.

Clin Orthop Relat Res 2020 Aug;478(8):1922-1935

Y. Kumabe, T. Fukui, S. Takahara, Y. Kuroiwa, M. Arakura, K. Oe, T. Oda, K. Sawauchi, T. Matsushita, T. Matsumoto, S. Hayashi, R. Kuroda, T. Niikura, Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Distraction osteogenesis has been broadly used to treat various structural bone deformities and defects. However, prolonged healing time remains a major problem. Various approaches including the use of low-intensity pulsed ultrasound, parathyroid hormone, and bone morphogenetic proteins (BMPs) have been studied to shorten the treatment period with limited success. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CORR.0000000000001288DOI Listing

Progesterone and endometrial cancer.

Authors:
Anne Gompel

Best Pract Res Clin Obstet Gynaecol 2020 Jun 9. Epub 2020 Jun 9.

Université de Paris, Hôpitaux Universitaires Port Royal-Cochin, Gynécologie Endocrinienne, 123 bd du Port Royal, Paris, 75014, France. Electronic address:

It is well established that unopposed estrogen, either endogenous or therapeutic, can induce endometrial hyperplasia and potentially endometrial cancer (EC). Anovulatory cycles, obesity, and insulin resistance are major risk factors for EC. Progestogen (progesterone and progestin), including levonorgestrel intrauterine device, are able to prevent or to treat hyperplasia, atypical hyperplasia, and even well-differentiated EC, as presented in this review. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpobgyn.2020.05.003DOI Listing

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort.

Respir Res 2020 Jul 30;21(1):202. Epub 2020 Jul 30.

Nordic Bioscience A/S, Herlev, Denmark.

Background: Lung epithelial damage, activation of the wound healing cascade, and remodeling of the extracellular matrix (ECM) play a major role in chronic obstructive pulmonary disease (COPD). The pro-peptide of type VI collagen has been identified as the hormone endotrophin. Endotrophin has been shown to promote fibrosis and inflammation, whereas von Willebrand factor (VWF) is a crucial part of wound healing initiation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-020-01461-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393910PMC

Lupus nephritis in a transgender woman on cross-sex hormone therapy: a case for the role of oestrogen in systemic lupus erythematosus.

Lupus 2020 Jul 30:961203320946372. Epub 2020 Jul 30.

Department of Internal Medicine, Brookwood Baptist Health Birmingham, Alabama, USA.

We present the case of a 22-year-old African American transgender women (male to female), who was admitted for fatigue, abdominal pain and lower extremity edema and was diagnosed with systemic lupus erythematosus (SLE) and lupus nephritis. Treatment with high-dose steroids and mycophenolate mofetil helped resolve her symptoms. She has remained off oestrogen therapy since admission and has not experienced any major complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203320946372DOI Listing

Dynamics of functional condition seedmans and liver in men with infertility under the influence of arginin therapy with the complex of L-carnitin and betainе.

Wiad Lek 2020 ;73(4):700-704

National University Of Pharmacy, Kharkiv, Ukraine.

Objective: The aim of this work was to study the hormonal status androgen-dependent indicators of the ejaculate, spermatogram parameters and liver transaminases in the blood of the infertile males for the treatment of arginine, carnitine and betaine.

Patients And Methods: Materials and methods: The parameters of spermograms, the levels of testosterone, estradiol, alanine aminotransferase and aspartate aminotransferase in the blood, and concentration of fructose in the ejaculate of 31 men with idiopathic pathospermia before and after using the L-Betargin, which contains 1 gram of arginine, 300 mg of L-carnitine and 1 gram of betaine.

Results: Results: It is shown that after treatment there is an increase of sperm concentration and their motility, increase the level of fructose in the ejaculate. Read More

View Article

Download full-text PDF

Source

Association between Bone Metabolism and Vestibular Problems in the Modified Romberg Test: Data from the 2009-2010 Korean National Health and Nutrition Examination Survey.

J Clin Med 2020 Jul 28;9(8). Epub 2020 Jul 28.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Korea.

Osteoporosis contributes to the occurrence of falling and vestibular problems, particularly in elderly patients. This study aimed to investigate the association between bone metabolism with vestibular problems and falling. A total of 4054 participants of the Korean National Health and Nutrition Examination Survey (KNHANES) from 2009 to 2010 aged ≥50 years old were surveyed on their history of falling, vestibular problems evaluated by the modified Romberg test, variables involving bone metabolism, and serum levels of vitamin D and alkaline phosphatase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9082415DOI Listing

Evolution of Inflammatory and Oxidative Stress Markers in Romanian Obese Male Patients with Type 2 Diabetes Mellitus after Laparoscopic Sleeve Gastrectomy: One Year Follow-Up.

Metabolites 2020 Jul 28;10(8). Epub 2020 Jul 28.

NIDNMD "Prof. N.C. Paulescu", 2nd district, 020042 Bucharest, Romania.

Geography is one of the key drivers of the significant variation in the etiopathogenic profile and prevalence of type 2 diabetes mellitus (T2DM) and obesity, therefore geographically based data are fundamental for implementing the appropriate interventions. Presently, the selection criteria of T2DM and obesity patients for laparoscopic sleeve gastrectomy (LSG) have not reached a worldwide consensus-highlighting the need for sharing experts' guidance in the preoperative evaluation, choice of the interventional procedure, perioperative management and patient long-term care. The aim of the current study was to evaluate the impact of LSG on T2DM (T2DM) remission in Romanian obese male patients, based on a multiparametric, prospective investigation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/metabo10080308DOI Listing

Effects of ferric carboxymaltose on markers of mineral and bone metabolism: a single-center prospective observational study of women with iron deficiency.

Bone 2020 Jul 27:115559. Epub 2020 Jul 27.

Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, USA; Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA; Jesse Brown Veterans Administration Medical Center, Chicago, Illinois 60612, USA.

Background: Two weekly infusions of ferric carboxymaltose (FCM) are commonly prescribed for treatment of iron-deficiency anemia. However, administration of FCM increases intact levels of fibroblast growth factor 23 (FGF23), which causes hypophosphatemia due to renal phosphate wasting, calcitriol deficiency and secondary hyperparathyroidism. The adverse effects of FCM on mineral metabolism and bone health emerged from case reports and secondary analyses of trials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2020.115559DOI Listing

MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression.

Steroids 2020 Jul 28;163:108709. Epub 2020 Jul 28.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Electronic address:

Background: Clinical treatment with high-dose of steroid hormone causes steroid-induced osteonecrosis of the femoral head (SONFH), whereas the internal regulation mechanism remains elusive. Numerous studies have reported that microRNAs participated in the development of SONFH through modulating gene expression. The aim of the current study was to clarify the function of microRNA-23b-3p (miR-23b-3p) and ZNF667 in SONFH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.steroids.2020.108709DOI Listing

Influence of Short-term Dietary and Therapeutic Iodine Restriction on the Therapeutic Effects of Radioactive Iodine Therapy in Patients with Graves' Disease.

Thyroid 2020 Jul 30. Epub 2020 Jul 30.

Juntendo University Graduate School of Medicine, Metabolism and Endocrinology, Tokyo, Japan;

Background: Several studies have investigated the factors affecting the effects of radioactive iodine (131I) treatment (RAIT) in patients with Graves' disease. However, the influence of dietary or therapeutic iodine on the effect of RAIT has not been fully elucidated yet. The aim of this study was to investigate whether dietary or therapeutic iodine before RAIT influences the therapeutic effects of RAIT with a fixed-dose regimen and a short-term restriction of iodine intake in an iodine sufficient area. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/thy.2020.0126DOI Listing

Acupuncture for menopausal symptoms in Chinese women: a systematic review.

Climacteric 2020 Jul 30:1-6. Epub 2020 Jul 30.

Department of Acupuncture-Moxibustion, Tsinghua University Chuiyangliu Hospital, Beijing, China.

Menopause-related symptoms are common problems of middle-aged women that can seriously affect their quality of life. Menopausal hormone therapy (MHT) for climacteric symptoms is the first choice recommended by the International Menopause Society and likewise by other societies and institutions covering this field. However, non-hormonal therapies can be an alternative effective option, especially for women who are not suitable for MHT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13697137.2020.1795115DOI Listing

Growth hormone deficiency as a complication of haemophilia - a case report and literature data.

Pediatr Endocrinol Diabetes Metab 2020 Jul 30. Epub 2020 Jul 30.

Department of Pediatrics, Oncology and Hematology, Warsaw Medical University, Warsaw, Poland.

Severe haemophilia carries an increased risk of life-threatening intracranial haemorrhages. Studies in adult survivors show a relatively high percentage of anterior pituitary hypofunction reported as the most frequent complication. We report the case of isolated growth hormone deficiency in a boy with severe haemophilia A. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/pedm.2020.95619DOI Listing

Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes.

Diabetologia 2020 Jul 29. Epub 2020 Jul 29.

National Institute of Diabetes, Digestive and Kidney Diseases/National Institutes of Health, 10 Center Dr. Bld 10-CRC, RM 5-3671, Bethesda, MD, 20892, USA.

Aims/hypothesis: Metformin is the only approved oral agent for youth with type 2 diabetes but its mechanism of action remains controversial. Recent data in adults suggest a primary role for the enteroinsular pathway, but there are no data in youth, in whom metformin efficacy is only ~50%. Our objectives were to compare incretin concentrations and rates of glucose production and gluconeogenesis in youth with type 2 diabetes before and after short-term metformin therapy compared with peers with normal glucose tolerance (NGT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00125-020-05236-yDOI Listing
July 2020
6.671 Impact Factor
  • Page 1 of 12609