604,631 results match your criteria Hormone Therapy


Fulvestrant in the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: A review.

Cancer Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery in Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai, China.

Nearly 75% of breast cancers are hormone receptor-positive (HR+) and human epidermal growth factor receptor type 2-negative (HER2-), making endocrine therapy the mainstay of treatment for HR+ and HER2- combination. Although endocrine therapy, such as therapy with fulvestrant, is widely used in the clinic, endocrine resistance (primary or secondary) is inevitable and poses a serious clinical concern. However, the therapeutic landscape of HR+/HER2- breast cancer is rapidly changing and evolving. Read More

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http://dx.doi.org/10.1002/cam4.2095DOI Listing

Local-regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial).

Breast Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Purpose: Women with HER2-positive breast cancer treated prior to effective anti-HER2 therapy have higher rates of local-regional recurrence (LRR) than those with HER2-negative disease. Effective systemic therapy, however, has been shown to decrease LRR. This study examines LRR in women with HER2-positive breast cancer treated on a single-arm prospective multicenter trial of adjuvant trastuzumab (H) and paclitaxel (T). Read More

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http://dx.doi.org/10.1007/s10549-019-05238-4DOI Listing

Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy.

Postgrad Med J 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Queen Mary Hospital, Hong Kong, China

Background: Over the last 10 years, there has been a major treatment revolution for early human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We aimed to explore the outcome of different neoadjuvant chemotherapy in a tertiary breast cancer centre with early HER2-positive breast cancer as well as factors associated with pathological complete response (pCR) and recurrence-free survival (RFS). The pattern of recurrence was also studied. Read More

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http://pmj.bmj.com/lookup/doi/10.1136/postgradmedj-2018-1357
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http://dx.doi.org/10.1136/postgradmedj-2018-135739DOI Listing
April 2019
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SEEN guidelines for the management and prevention of acute adrenal insufficiency.

Endocrinol Diabetes Nutr 2019 Apr 16. Epub 2019 Apr 16.

Servicio de Endocrinología y Nutrición, Hospital Clínico, Barcelona, España. Electronic address:

Acute adrenal insufficiency (AAI) is a potentially fatal medical emergency whose prevention and treatment should be known by all medical professionals. AAI is an underdiagnosed condition because of its non-specific symptoms, but its diagnosis and early treatment with glucocorticoids is vital. It may be triggered by a de novo deficiency in cortisol synthesis or occur secondarily to omission of hormone replacement therapy (corticosteroids) or inadequate adjustment of the dose required in stress situations in patients previously diagnosed with adrenal insufficiency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S25300164193003
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http://dx.doi.org/10.1016/j.endinu.2019.01.004DOI Listing
April 2019
1 Read

The effect of atorvastatin on cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia: A pilot study.

Pharmacol Rep 2019 Jan 31;71(3):417-421. Epub 2019 Jan 31.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Individuals with non-classic congenital adrenal hyperplasia (NC-CAH) often show evidence of hyperandrogenism, including premature pubarche, accelerated linear growth velocity, short final height, hirsutism, acne, alopecia, impaired ovulation, menstrual dysfunction and subfertility. Although statins were found to reduce elevated levels of androgens in subjects with this disorder, no previous study has investigated whether 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors affect cardiometabolic risk factors in patients with NC-CAH.

Methods: We studied 12 women with NC-CAH, 6 of whom because of coexisting hypercholesterolemia received atorvastatin (20-40 mg daily). Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.014DOI Listing
January 2019

Heme prevents highly amyloidogenic human calcitonin (hCT) aggregation: A potential new strategy for the clinical reuse of hCT.

J Inorg Biochem 2019 Apr 1;196:110686. Epub 2019 Apr 1.

Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of chemistry and chemical Engineering, Huazhong university of Science and Technology, Wuhan 430074, People's Republic of China. Electronic address:

Irreversible aggregation can extremely limit the bioavailability and therapeutic activity of peptide-based drugs. Thus, peptide fibrillation is an excellent challenge for biotechnological drug development. Human calcitonin (hCT) is such a peptide hormone known for its hypocalcaemic effect but has limited pharmaceutical potential due to a high tendency to aggregate. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2019.03.026DOI Listing

Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

FASEB J 2019 Apr 19:fj201802347RRR. Epub 2019 Apr 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates. To compare how stromal cells derived from women who are lean or obese influence response to the aromatase inhibitor (anastrazole), we incorporated patient-derived stroma in a previously characterized MCF7-derived duct model. Coculture with adipose stromal cells enabled the metabolism of testosterone (T) to E, which induced estrogen response element activity, epithelial proliferation, and hyperplasia in MCF7 cells. Read More

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http://dx.doi.org/10.1096/fj.201802347RRRDOI Listing

The capability of L-carnitine-mediated antioxidant on cock during aging: evidence for the improved semen quality and enhanced testicular expressions of GnRH1, GnRHR, and melatonin receptors MT 1/2.

Poult Sci 2019 Apr 18. Epub 2019 Apr 18.

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education and Department of Basic Veterinary Medicine, College of Animal Science and Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China.

Precise natural anti-oxidative compounds have facilitated the research of infertile gametes and the development of novel bio-therapeutics, especially the molecules that are based on the reduction of oxidative stress, such as L-carnitine (LC). In addition to, the defect in the functioning of sperm mitochondrial and the decreasing seminal antioxidant ability due to aging, its essential role in permitting the mitochondrial import and oxidation of long chain fatty acids is worthy. Therefore, current study was designed to investigate the effects of dietary LC on semen quality, seminal antioxidant activity, and their implications for the fertility in aged cocks for 12 wk. Read More

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http://dx.doi.org/10.3382/ps/pez201DOI Listing
April 2019
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Effects of Exercise Combined with Finasteride on Hormone and Ovarian Function in Polycystic Ovary Syndrome Rats.

Int J Endocrinol 2019 13;2019:8405796. Epub 2019 Mar 13.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Exercise can reduce androgen and insulin levels in polycystic ovary syndrome (PCOS) patients. Finasteride is also presumed to improve the developing follicle environment. Therefore, the aim of this study was to observe the effects of the combination of exercise and finasteride therapy on hormone levels and ovarian morphology in rats with polycystic ovary syndrome. Read More

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http://dx.doi.org/10.1155/2019/8405796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436361PMC

Medroxyprogesterone Acetate Decreases Th1, Th17, and Increases Th22 Responses via AHR Signaling Which Could Affect Susceptibility to Infections and Inflammatory Disease.

Front Immunol 2019 3;10:642. Epub 2019 Apr 3.

Department of Neurobiology, Physiology and Behavior, University of California, Davis, Davis, CA, United States.

A synthetic progestin, medroxyprogesterone acetate (MPA), was used in a novel study to determine progestin effects on human purified macrophages and Th1, Th2, Th17, Th22 cells. MPA concentrations were equivalent to those in the serum of women after 6 and 9 months of progestin use. MPA has no effect on the proliferation of PBMCs and CD4+ T cell clones induced by immobilized anti-CD3 antibodies or by antigen (streptokinase). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456711PMC

Appraisal of Core Therapy, Supportive Therapy, and Alternative Therapy in a Tertiary Care Rural Hospital of Vidarbha Region in Correlation to Plethora of Menopausal Problems.

J Midlife Health 2019 Jan-Mar;10(1):14-21

OBGY, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India.

Context: Menopause is a crucial phase of the women fraternity which marks the end of reproductive age. Mostly it is physiological; however, certain conditions may lead to premature menopause. Menopause has an extensive spectrum of symptoms which are extremely bothersome. Read More

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http://dx.doi.org/10.4103/jmh.JMH_131_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459068PMC

Menopausal Hot Flashes: A Concise Review.

J Midlife Health 2019 Jan-Mar;10(1):6-13

Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Hot flashes (HFs), defined as transient sensations of heat, sweating, flushing, anxiety, and chills lasting for 1-5 min, constitute one of the most common symptoms of menopause among women though only a few seek treatment for these. The basis of HFs lies in abnormal hypothalamic thermoregulatory control resulting in abnormal vasodilatory response to minor elevations of core body temperature. Recent data suggest an important role for calcitonin gene-related peptide, hypothalamic kisspeptin, neurokinin B and dynorphin signal system, serotonin, norepinephrine in causation of HFs in addition to estrogen deficiency which plays a cardinal role. Read More

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http://dx.doi.org/10.4103/jmh.JMH_7_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459071PMC

Mineral Metabolism Disturbances and Arteriovenous Fistula Maturation.

Eur J Vasc Endovasc Surg 2019 Apr 15. Epub 2019 Apr 15.

Kidney Research Institute, University of Washington, Seattle, WA, USA.

Background: The arteriovenous fistula (AVF) is central to haemodialysis treatment, but up to half of surgically created AVF fail to mature. Chronic kidney disease often leads to mineral metabolism disturbances that may interfere with AVF maturation through adverse vascular effects. This study tested associations between mineral metabolism markers and vein histology at AVF creation and unassisted and overall clinical AVF maturation. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.01.022DOI Listing

Time for a reassessment of the treatment of hypothyroidism.

BMC Endocr Disord 2019 Apr 18;19(1):37. Epub 2019 Apr 18.

, 113 Andersons Road, Yandina, QLD 4561, Australia.

Background: In the treatment for hypothyroidism, a historically symptom-orientated approach has given way to reliance on a single biochemical parameter, thyroid stimulating hormone (TSH).

Main Body: The historical developments and motivation leading to that decision and its potential implications are explored from pathophysiological, clinical and statistical viewpoints. An increasing frequency of hypothyroid-like complaints is noted in patients in the wake of this directional shift, together with relaxation of treatment targets. Read More

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https://bmcendocrdisord.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12902-019-0365-4DOI Listing
April 2019
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Adipokines Regulate the Expression of Tumor-Relevant MicroRNAs.

Obes Facts 2019 Apr 18;12(2):211-225. Epub 2019 Apr 18.

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Background: Increasing prevalence of obesity requires the investigation of respective comorbidities, including tumor diseases like colorectal, renal, post-menopausal breast, prostate cancer, and leukemia. To date, molecular mechanisms of the malignant transformation of these peripheral tissues induced by obesity remain unclear. Adipose tissue secretes factors with hormone-like functions, the adipokines, and is therefore categorized as an endocrine organ. Read More

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https://www.karger.com/Article/FullText/496625
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http://dx.doi.org/10.1159/000496625DOI Listing
April 2019
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The effect of testosterone therapy on personality traits of trans men: a controlled prospective study in Germany and Switzerland.

Psychiatry Res 2019 Apr 1;276:31-38. Epub 2019 Apr 1.

Department of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, Rämistrasse 100, 8002 Zürich, Switzerland.

Gender dysphoria in transgender men is generally treated with exogenous testosterone administration aiming to suppress secondary female sex characteristics and achieve masculinization. However, the effect of testosterone on the personality of transgender men remains largely unknown. Therefore, we conducted a controlled study with 23 trans men (M = 27. Read More

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http://dx.doi.org/10.1016/j.psychres.2019.03.053DOI Listing
April 2019
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Chronic exposure to green light aggravates high-fat diet-induced obesity and metabolic disorders in male mice.

Ecotoxicol Environ Saf 2019 Apr 15;178:94-104. Epub 2019 Apr 15.

State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, PR China; School of Life Science and Technology, China Pharmaceutical University, Nanjing, 211198, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

Light is involved in many critical physiological or biochemical processes of human beings, such as visual sensing and the production of vitamin D. Recent studies have showed that the lights of different wavelengths have a profound influence in life activities. For example, blue light promotes alertness, whereas green light (GL) induces sleep in mice. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.013DOI Listing

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings.

Int J Pharm 2019 Apr 15;564:90-97. Epub 2019 Apr 15.

Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria; Institute of Pharmaceutical Sciences, Department Pharmaceutical Technology and Biopharmacy, University of Graz, Universitaetsplatz 1, 8010 Graz, Austria. Electronic address:

The application of ethylene-vinyl acetate (EVA) copolymers in reservoir-type intra-vaginal rings (IVRs) offers advantages over silicones including i) versatile properties, ii) absence of curing chemistry, and iii) continuous and flexible processing via co-extrusion. Thus, we investigated the capability of EVA based IVRs to deliver broad ranges of estradiol (E2) thereby, fulfilling the requirements of local and systemic hormone replacement therapy (HRT) and contraception. To circumvent the high material needs associated with co-extrusion, we implemented a small-scale screening procedure that accurately predicts the E2 release from IVRs comprising E2 below its solubility concentration in the core. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.041DOI Listing
April 2019
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Differential expression of androgen receptor variants in hormone-sensitive prostate cancer xenografts, castration-resistant sublines, and patient specimens according to the treatment sequence.

Prostate 2019 Apr 18. Epub 2019 Apr 18.

Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.

Background: Androgen receptor variants (AR-vs), especially AR-v7 and AR-v 5, 6, and 7 exon-skipped (AR-v567es), are reportedly key players in the development of castration-resistant prostate cancer (CRPC). We previously established a mouse xenograft model (JDCaP) from a metastatic skin lesion from a Japanese patient with CRPC and that was revealed to exhibit androgen sensitivity. In the present study, we established multiple castration-resistant xenograft models from JDCaP mice to investigate the biological features of CRPC. Read More

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http://dx.doi.org/10.1002/pros.23816DOI Listing

Differential expression of senescence tumour markers and its implications on survival outcomes of breast cancer patients.

PLoS One 2019 18;14(4):e0214604. Epub 2019 Apr 18.

Ingham Institute for Applied Medical Research, Liverpool, NSW Australia.

Breast cancer is a heterogeneous disease displaying different histopathological characteristics, molecular profiling and clinical behavior. This study describes the expression patterns of senescence markers P53, DEC1 and DCR2 and assesses their significance on patient survival as a single or combined marker with P16 or P14 using breast cancer progression series. One thousand and eighty (1080) patients with primary invasive ductal carcinoma, no special type, were recruited through an 11-year retrospective study period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214604PLOS
April 2019
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The unmasking of hidden severe hyponatremia after long-term combination therapy in exacerbated bipolar patients: a case series.

Int Clin Psychopharmacol 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Naples, Italy.

Hyponatremia is occasionally unmasked in psychiatric patients during hospitalization after routine blood and urinary tests, and correlates in most cases with an inappropriate secretion of antidiuretic hormone, mainly due to iatrogenic factors. Only a few studies have regarded the combination of psychotropic drugs as triggers of chronic, asymptomatic hyponatremia in bipolar patients, who require to be hospitalized because of the exacerbation of their mental illness. We presented three clinical cases of patients affected by a long-term psychiatric disorder and under polypharmacotherapy for several months. Read More

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http://dx.doi.org/10.1097/YIC.0000000000000265DOI Listing
April 2019
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Contraception Care for Transmasculine Individuals on Testosterone Therapy.

J Midwifery Womens Health 2019 Apr 18. Epub 2019 Apr 18.

Yale School of Nursing, Orange, Connecticut.

Contraception and fertility-associated advisement is needed for any individual with a uterus who is engaging in sexual activity with reproductive potential. As greater awareness spreads regarding the health care needs of transgender, nonbinary, and gender-nonconforming individuals, the research on evidence-based care for these populations lags behind. Many clinicians may not be well versed in the best practices to support the sexual and reproductive well-being of individuals who are taking gender-affirming hormone therapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jmwh.12962
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http://dx.doi.org/10.1111/jmwh.12962DOI Listing
April 2019
2 Reads

Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

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http://dx.doi.org/10.14283/jfa.2019.5DOI Listing
January 2019

Evaluation of appropriate use of bisphosphonates and denosumab in patients with cancer.

J Oncol Pharm Pract 2019 Apr 18:1078155219842277. Epub 2019 Apr 18.

1 Pharmacy Department, Indianapolis VA Medical Center, Indianapolis, USA.

Background: National guidelines recommend screening and treatment for cancer-related bone disease and continued monitoring of bone-modifying agents. It is unclear whether a standardized screening tool is utilized to identify eligible patients and ensure appropriate supportive care is implemented. The purpose of this study was to evaluate current prescribing practices and optimize management of bone-modifying agents. Read More

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http://dx.doi.org/10.1177/1078155219842277DOI Listing
April 2019
3 Reads

Higher ER load is not associated with better outcome in stage 1-3 breast cancer: a descriptive overview of quantitative HR analysis in operable breast cancer.

Breast Cancer Res Treat 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Oncology, Leiden University Medical Centre, Leiden, The Netherlands.

Purpose: In breast cancer, hormone receptor (HR) status is generally a qualitative measure; positive or negative. Quantitatively measured oestrogen and progesterone receptors (ER and PR) are frequently proposed prognostic and predictive markers, some guidelines even provide different treatment options for patients with strong versus weak expression.

Aim: To evaluate quantitative HR load assessed by immunohistochemistry as a prognostic and predictive measure in stage 1-3 breast cancer. Read More

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http://link.springer.com/10.1007/s10549-019-05233-9
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http://dx.doi.org/10.1007/s10549-019-05233-9DOI Listing
April 2019
2 Reads

[Specific cases of slipped capital femoral epiphysis : Endocrinopathies, hormone therapy and other rare causes].

Orthopade 2019 Apr 17. Epub 2019 Apr 17.

Orthopädische Klinik, Olgahospital, Klinikum Stuttgart, Kriegsbergstr. 62, 70174, Stuttgart, Deutschland.

In slipped capital femoral epiphysis (SCFE) atypical causes can be found in about 5% of cases. The patients' age differs from the typical age of SCFE patients of between age 10 and 16. There are numerous causes of atypical SCFE: different endocrine disorders, sequelae of chronic renal failure and effects of radiation and chemotherapy on the proximal femoral physis. Read More

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http://dx.doi.org/10.1007/s00132-019-03728-3DOI Listing
April 2019
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[Comprehensive treatment of adrenal cortical carcinoma].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):298-301

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Objective: To investigate the clinical and functional imaging examination and pathological features of adrenocortical carcinoma (ACC), in order to improve the diagnosis and treatment of ACC.

Methods: The clinical data of 93 patients with ACC were analyzed retrospectively. Their diagnosis, surgical treatment and follow-up of mitotane medcine therapy were madeaccording to clinical manifestations, adrenal endocrine function determination, imaging examination characteristics and histopathological results. Read More

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April 2019
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A novel NPM1-RARG-NPM1 chimeric fusion in acute myeloid leukaemia resembling acute promyelocytic leukaemia but resistant to all-trans retinoic acid and arsenic trioxide.

Br J Cancer 2019 Apr 18. Epub 2019 Apr 18.

Department of Hematology, The 2nd Affiliated Hospital of Harbin Medical University, 150001, Harbin, China.

The RARG gene is a member of the nuclear hormone receptor superfamily and shares high homology with RARA and RARB. RARA is involved in translocation with PML in acute promyelocytic leukaemia (APL). Little is known about RARB or RARG rearrangement. Read More

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http://www.nature.com/articles/s41416-019-0456-z
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http://dx.doi.org/10.1038/s41416-019-0456-zDOI Listing
April 2019
3 Reads

Myelin repair stimulated by CNS-selective thyroid hormone action.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Physiology & Pharmacology and Program in Chemical Biology, Oregon Health & Science University, Portland, Oregon, USA.

Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS that stimulate myelin repair. During development, thyroid hormone (TH) promotes myelination through enhancing oligodendrocyte differentiation; however, TH itself is unsuitable as a remyelination therapy due to adverse systemic effects. Read More

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http://dx.doi.org/10.1172/jci.insight.126329DOI Listing

The Effect of Gonadotropin-Releasing Hormone Analogue on Final Adult Height in Children with Idiopathic Short Stature.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objective: Assess final adult height (FAH) in children with short stature treated with gonadotropin-releasing hormone analogue (GnRHa).

Methods: All patients with idiopathic short stature (ISS) with normally timed puberty and a Tanner stage between 2-3, who achieved their final adult height (FAH) between 2005 and 2015, were included in this clinical historical cohort study. Height gain, FAH and, mid-parental height of 28 children with ISS who received GnRHa treatment for 1. Read More

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http://dx.doi.org/10.1159/000499929DOI Listing
April 2019
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MANAGEMENT AND OUTCOMES OF GIANT PROLACTINOMA: A SERIES OF 71 PATIENTS.

Endocr Pract 2019 Apr;25(4):340-352

To describe outcomes of patients with giant prolactinoma (≥4 cm) and identify predictors of therapeutic response. In this retrospective study, complete biochemical and structural response were defined as prolactin (PRL) ≤25 ng/mL and no visible tumor at follow-up, respectively. Giant prolactinoma (median size, 4. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0392
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http://dx.doi.org/10.4158/EP-2018-0392DOI Listing
April 2019
2 Reads

Relationship between sex steroids and deterioration of bone microarchitecture in older men: the prospective STRAMBO Study.

J Bone Miner Res 2019 Apr 17. Epub 2019 Apr 17.

INSERM UMR 1033, University of Lyon, Hôpital Edouard Herriot, Lyon, France.

In older men, low estrogen levels are associated with poor bone microarchitecture. Data on androgens are discordant. We studied the link between baseline sex steroid levels (total 17β -estradiol [17βE2], total testosterone [tT], calculated bioavailable 17βE2 [bio-17βE2] and apparent free testosterone concentration [AFTC]) and bone microarchitecture deterioration assessed prospectively in a 820 older men followed up for 8 years. Read More

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http://dx.doi.org/10.1002/jbmr.3746DOI Listing

[Menopausal hormone therapy. Effects on bone and body composition].

Rev Med Suisse 2019 Apr;15(647):836-839

Centre des maladies osseuses, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.

Changes occurring at menopause can be mitigated by prescribing menopausal hormone replacement therapy (HRT). Recent publications from the CoLaus/OsteoLaus cohorts provide important insights into the effects of HRT and after its discontinuation on bone and body composition. HRT has a beneficial effect on bone mineral density, bone microarchitecture and fracture prevention. Read More

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April 2019
3 Reads

Higher amounts of Sedentary Time are Associated with Short Sleep Duration and Poor Sleep Quality in Postmenopausal Women.

Sleep 2019 Apr 17. Epub 2019 Apr 17.

Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

Study Objectives: To evaluate the associations between sedentary time, total (total-PA), light (light-PA), moderate (MOD-PA), and vigorous (VIG-PA) physical activity with indices of sleep in postmenopausal women.

Methods: Baseline self-reported data from the Women's Health Initiative Observational Study (n=75,074) were used in this cross-sectional analysis. Total-PA, light-PA, MOD-PA, and VIG-PA were categorized by metabolic equivalents of the activity [MET-hour (hr)/week (wk)] and were estimated using validated questionnaires. Read More

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http://dx.doi.org/10.1093/sleep/zsz093DOI Listing
April 2019
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Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis.

Int J Hyperthermia 2019 Apr 17:1-7. Epub 2019 Apr 17.

a Department of Gynecology, Shanghai First Maternity and Infant Hospital , Tongji University School of Medicine , Shanghai , PR China.

Objective: To evaluate the combined efficacy of high-intensity focused ultrasound (HIFU), gonadotropin-releasing hormone agonist (GnRH-a) and the levonorgestrel-releasing intrauterine system (LNG-IUS) for the treatment of severe adenomyosis.

Method: Four hundred and sixty-six patients with adenomyosis admitted to the Department of Gynecology of Shanghai First Maternity and Infant Hospital underwent HIFU treatment, and then were consecutively administered with GnRH-a 1 d, 1 month and 3 months after HIFU treatment. The uterine size was then measured with ultrasound or MRI 2-4 weeks after three cycles of GnRH-a injection. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1
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http://dx.doi.org/10.1080/02656736.2019.1595179DOI Listing
April 2019
2 Reads

The effectiveness of high intensity intermittent training on metabolic, reproductive and mental health in women with polycystic ovary syndrome: study protocol for the iHIT- randomised controlled trial.

Trials 2019 Apr 16;20(1):221. Epub 2019 Apr 16.

Institute for Health and Sport, Victoria University, PO Box 14428, Melbourne, Victoria, 8001, Australia.

Background: Polycystic ovary syndrome (PCOS) is a reproductive-metabolic condition. Insulin resistance is a hallmark of PCOS and is related to increased hyperandrogenism that drives inherent metabolic, reproductive and psychological features of the syndrome. Insulin resistance in women with PCOS is managed by weight loss, lifestyle interventions (i. Read More

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http://dx.doi.org/10.1186/s13063-019-3313-8DOI Listing
April 2019
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Iron Metabolism in Chronic Kidney Disease Patients.

Contrib Nephrol 2019 16;198:103-111. Epub 2019 Apr 16.

Division of Nephrology, Department of Medicine, Showa University, School of Medicine, Tokyo, Japan.

Background: Anemia is a common comorbidity in patients with chronic kidney disease (CKD) and occurs due to diminished renal function. The main cause of such anemia is decreased erythropoietin (EPO) production and secretion from the kidney and a lower erythropoietic response to EPO. Treatment therefore involves erythropoiesis-stimulating agents (ESAs). Read More

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https://www.karger.com/Article/FullText/496369
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http://dx.doi.org/10.1159/000496369DOI Listing
April 2019
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Adjuvant mitotane therapy is beneficial in non-metastatic adrenocortical carcinoma at high risk of recurrence.

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

M Terzolo, Department of Clinical and Biological Sciences, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy.

Objective: Many patients with adrenocortical carcinoma (ACC) suffer from tumor recurrence despite radical surgery. Evidence on the post-operative use of mitotane is controversial and no predictors of response are available. We aimed to assess whether adjuvant mitotane treatment may prolong survival in patients with non-metastatic ACC following complete resection and whether ACC patients at high risk of recurrence may benefit from treatment. Read More

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https://eje.bioscientifica.com/view/journals/eje/aop/eje-18-
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http://dx.doi.org/10.1530/EJE-18-0923DOI Listing
April 2019
2 Reads

Common Breast Problems.

Am Fam Physician 2019 Apr;99(8):505-514

Thomas Jefferson University, Philadelphia, PA, USA.

Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. The initial workup includes a detailed clinical history and physical examination. Women presenting with a breast mass will require imaging and further assessment to exclude cancer. Read More

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April 2019
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Triple treatment of high-risk prostate cancer. A matched cohort study with up to 19 years follow-up comparing survival outcomes after triple treatment and treatment with hormones and radiotherapy.

Scand J Urol 2019 Apr 16:1-7. Epub 2019 Apr 16.

c Sahlgrenska Academy and University Hospital , University of Gothenburg , Gothenburg , Sweden.

Purpose: To evaluate the efficacy of a triple treatment strategy, including surgery, on high risk prostate cancer comparing long-term survival outcome with a cohort receiving standard radiotherapy with endocrine therapy.

Materials And Methods: This study compared two cohorts in survival outcomes, matched on the year of diagnosis and age. In both groups there was a curative intention to treat localized high-risk prostate cancer (one or more of Gleason score 8-10, PSA 20-50 or stage T3), diagnosed between 1995-2010, follow-up at the end of 2014. Read More

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http://dx.doi.org/10.1080/21681805.2019.1600580DOI Listing
April 2019
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[Clinical efficacy of Bushen Huoxue Anshen therapy in treating perimenopausal sleep disorder with kidney deficiency and blood stasis].

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1069-1074

Traditional Chinese Medicine Hospital of Huairou District Beijing 101400,China.

The efficacy and safety of traditional Chinese medicine and acupuncture in the treatment of kidney-deficiency and bloodstasis perimenopausal sleep disorders were evaluated. A total of 67 subjects who completed the study were randomly divided into two groups. The traditional Chinese medicine group was orally given Bushen Huoxue Anshen Fang,and the acupuncture group was given acupuncture treatment. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181225.002DOI Listing
March 2019
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Is trigonitis a neglected, imprecise, misunderstood, or forgotten diagnosis?

Low Urin Tract Symptoms 2019 Apr 15. Epub 2019 Apr 15.

Urology Department, UT Southwestern Medical Center, Dallas, Texas.

To consolidate our understanding of "trigonitis" and its relevance in current urologic practice, we reviewed the literature on this entity. The MEDLINE, EMBASE, and Cochrane databases (1905 to present) were systematically reviewed for any English language articles addressing the following terms: trigonitis, cystitis trigoni, cystitis cystica, squamous metaplasia, pseudomembranous trigonitis, vaginal metaplasia, infection or inflammation of the trigone, and trigonitis in recurrent urinary tract infections (rUTI). Abstracts or articles not focused on trigonitis, or those only repeating findings from other original articles on trigonitis, and studies in children or men were excluded. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/luts.12264
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http://dx.doi.org/10.1111/luts.12264DOI Listing
April 2019
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Social Network Organization, Structure, and Patterns of Influence Within a Community of Transgender Women in Lima, Peru: Implications for Biomedical HIV Prevention.

AIDS Behav 2019 Apr 15. Epub 2019 Apr 15.

Asociacion Civil Impacta Salud y Educacion, Lima, Peru.

Understanding social network structures can contribute to the introduction of new HIV prevention strategies with socially marginalized populations like transgender women (TW). We conducted 20 semi-structured interviews and four focus groups (n = 32) with TW from selected social networks in Lima, Peru between May and July, 2015. Participants described layers of social influence from diverse actors in their social networks. Read More

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http://dx.doi.org/10.1007/s10461-019-02506-8DOI Listing
April 2019
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Functional survival of rat pituitary gland in hypothermic storage for pituitary transplantation.

Pituitary 2019 Apr 15. Epub 2019 Apr 15.

Department of Neurosurgery, College of Medicine, Cell Death Disease Research Center, St. Vincent's Hospital, The Catholic University of Korea, 222, Banpodaero, Seochogu, Seoul, South Korea.

Purpose: Deteriorated pituitary function can lead to serious complications that might need lifelong hormone replacement therapy. However, long-term hormone administration can have significant adverse effects. Thus, it would be more desirable to restore pituitary function by pituitary transplantation. Read More

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http://dx.doi.org/10.1007/s11102-019-00959-7DOI Listing
April 2019
2 Reads

Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis.

Mol Ther Methods Clin Dev 2019 Jun 14;13:344-358. Epub 2019 Mar 14.

Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada.

Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder causing endocrine, musculoskeletal, and neurological dysfunction. PWS is caused by the inactivation of contiguous genes, complicating the development of targeted therapeutics. Clinical trials are now underway in PWS, with more trials to be implemented in the next few years. Read More

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http://dx.doi.org/10.1016/j.omtm.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447752PMC
June 2019
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Protective effects of leptin against cerebral ischemia/reperfusion injury.

Exp Ther Med 2019 May 13;17(5):3282-3290. Epub 2019 Mar 13.

Department of Medical Affairs, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China.

In recent years, the use of thrombolytic therapy for treating ischemia/reperfusion injury has resulted in damage to the self-regulatory mechanisms of the brain. This is due to the increased production of free radicals, excitatory amino acids and pro-inflammatory cytokines causing secondary damage to the brain. Simple thrombolytic therapy has not been the best approach for treating ischemia/reperfusion injury. Read More

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http://dx.doi.org/10.3892/etm.2019.7377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447799PMC
May 2019
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Gatekeeping hormone replacement therapy for transgender patients is dehumanising.

Authors:
Florence Ashley

J Med Ethics 2019 Apr 15. Epub 2019 Apr 15.

Although informed consent models for prescribing hormone replacement therapy are becoming increasingly prevalent, many physicians continue to require an assessment and referral letter from a mental health professional prior to prescription. Drawing on personal and communal experience, the author argues that assessment and referral requirements are dehumanising and unethical, foregrounding the ways in which these requirements evidence a mistrust of trans people, suppress the diversity of their experiences and sustain an unjustified double standard in contrast to other forms of clinical care. Physicians should abandon this unethical requirement in favour of an informed consent approach to transgender care. Read More

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http://dx.doi.org/10.1136/medethics-2018-105293DOI Listing
April 2019
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Longitudinal Case Study of Transgender Voice Changes Under Testosterone Hormone Therapy.

J Voice 2019 Apr 13. Epub 2019 Apr 13.

Graduate Program for Neuroscience, Boston University, Boston, Massachusetts; Department of Speech, Language, and Hearing Sciences, Boston University, Boston, Massachusetts; Department of Biomedical Engineering, Boston University, Boston, Massachusetts; Department of Otolaryngology - Head and Neck Surgery, Boston University School of Medicine, Boston, Massachusetts.

The purpose of this study was to comprehensively evaluate voice and speech changes in one healthy 30-year-old transgender male undergoing testosterone therapy for transition. Testing occurred at three timepoints before cross-sex hormone therapy and every 2 weeks thereafter for 1 year. Data collected included measures of acoustics, aerodynamics, and laryngeal structure and function via flexible laryngoscopy. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.03.006DOI Listing
April 2019
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Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.

Gynecol Oncol 2019 Apr 13. Epub 2019 Apr 13.

Duke University Medical Center, Durham, NC, United States of America.

Objective: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance to endocrine therapy, especially aromatase inhibitors (AIs). The purpose of this study was to evaluate the frequency and clinical relevance of ESR1 genomic alterations in gynecologic malignancies. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.04.010DOI Listing
April 2019
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Cardiac arrhythmias secondary to hormone therapy in trans women.

Expert Rev Cardiovasc Ther 2019 Apr 15. Epub 2019 Apr 15.

b Division of Cardiology, Kingston Health Science Center , Queen's University , Kingston , Ontario , Canada.

Introduction: With greater social acceptance and the evolution of transgender medicine as a specialty, more trans women are seeking hormone therapy (HT). Several studies have identified an increase in cardiovascular disease in trans women, however no studies have investigated the incidence of arrhythmias. Using two cases from the authors' clinic as examples, we propose that hormone therapy in trans women may increase the risk of cardiac arrhythmias. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2019.1
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http://dx.doi.org/10.1080/14779072.2019.1606713DOI Listing
April 2019
2 Reads
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