1,505,882 results match your criteria Hormone Research in Paediatrics [Journal]


Oocyte-Secreted Factors Synergize with FSH to Promote Aromatase Expression in Primary Human Cumulus Cells.

J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology and Biophysics, University of Illinois at Chicago.

Context: The role of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) on aromatase regulation is poorly understood in humans.

Objective: Determine GDF9 and BMP15 effects on follicle-stimulating hormone (FSH) stimulation of estradiol production in primary human cumulus granulosa cells (GCs). We hypothesized that the combination of GDF9 and BMP15 potentiates FSH-induced aromatase expression. Read More

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December 2018

Expression of GHR and downstream signaling genes in human adipose tissue - relation to obesity and weight-change.

J Clin Endocrinol Metab 2018 Dec 12. Epub 2018 Dec 12.

Department of Molecular and Clinical Medicine, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Context: Growth hormone (GH) is a strong regulator of metabolism. In obesity, both GH secretion and adipose tissue GHR gene expression are decreased. More detailed information on the regulation of GHR, STAT3/5 and downstream-regulated genes in human adipose tissue during diet-induced weight loss and weight gain is lacking. Read More

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December 2018

Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough.

Korean J Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.

Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response to ICS in patients with upper airway cough syndrome (UACS) or unexplained chronic cough (UCC). Sixty-eight patients with UACS and 33 patients with UCC (duration of cough ≥ 8 weeks) were treated with ICS: 250 µg of fluticasone propionate or 400 µg of budesonide twice a day at physician's discretion. Read More

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December 2018

Desert plant bacteria reveal host influence and beneficial plant growth properties.

PLoS One 2018 12;13(12):e0208223. Epub 2018 Dec 12.

Desert Agriculture Initiative, King Abdullah University of Science and Technology (KAUST), Biological and Environmental Sciences and Engineering Division (BESE), Thuwal, Kingdom of Saudi Arabia.

Deserts, such as those found in Saudi Arabia, are one of the most hostile places for plant growth. However, desert plants are able to impact their surrounding microbial community and select beneficial microbes that promote their growth under these extreme conditions. In this study, we examined the soil, rhizosphere and endosphere bacterial communities of four native desert plants Tribulus terrestris, Zygophyllum simplex, Panicum turgidum and Euphorbia granulata from the Southwest (Jizan region), two of which were also found in the Midwest (Al Wahbah area) of Saudi Arabia. Read More

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December 2018

Midregional proadrenomedullin predicts reduced blood pressure and glucose elevation over time despite enhanced progression of obesity markers.

J Hypertens 2018 Dec 10. Epub 2018 Dec 10.

Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.

Objectives: Elevated plasma levels of the vasodilating hormone adrenomedullin (ADM) predict cardiovascular disease and have been associated with hypertension and obesity. We aimed to examine the independent relationship between ADM and the progression of major cardiometabolic risk factors during long-term follow-up.

Methods: We studied midregional pro-ADM (MR-proADM) in fasting plasma in 3298 participants from the population-based Malmö Diet and Cancer Study - Cardiovascular Cohort, re-examined after 17 years of follow-up and related baseline MR-proADM to cardiometabolic risk factors cross-sectionally and longitudinally. Read More

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December 2018

Mechanisms of disease: The endocrinology of obstructive sleep apnoea.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

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December 2018

Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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December 2018

Chemical activation of the ethylene signalling pathway promotes Fusarium graminearum resistance in detached wheat heads.

Phytopathology 2018 Dec 12. Epub 2018 Dec 12.

University of Lethbridge, Department of Biological Sciences, Lethbridge, Alberta, Canada ;

Plant signalling hormones, such as ethylene, have been shown to affect the host response to various pathogens. Often the resistance responses to necrotrophic fungi are mediated through synergistic interactions of ethylene (ET) with the jasmonate signalling pathway. On the other hand, ethylene is also an inducer of senescence and cell death, which could be beneficial for some invading necrotrophic pathogens. Read More

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December 2018

The Dual Effect of the Brassinosteroid Pathway on Rice Black Streaked Dwarf Virus Infection by Modulating the Peroxidase-Mediated Oxidative Burst and Plant Defense.

Mol Plant Microbe Interact 2018 Dec 12. Epub 2018 Dec 12.

Fenghua Road 818,Ningbo, China , 315211 ;

The phytohormone brassinosteroids (BR) not only played key roles in regulating plant growth development but also involved in modulating plant defense system upon pathogens attack. Our previous study found that BR pathway was susceptible to Rice Blacked-Streaked Dwarf Virus (RBSDV), a devastating pathogen in rice. However, the detailed mechanism of BR-mediated susceptibility remains unclear. Read More

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December 2018

Activin A in Mammalian Physiology.

Physiol Rev 2019 Jan;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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January 2019

The Activity of Peptides of the Calcitonin Family in Bone.

Physiol Rev 2019 Jan;99(1):781-805

Department of Medicine, University of Auckland , Auckland , New Zealand.

Calcitonin was discovered over 50 yr ago as a new hormone that rapidly lowers circulating calcium levels. This effect is caused by the inhibition of calcium efflux from bone, as calcitonin is a potent inhibitor of bone resorption. Calcitonin has been in clinical use for conditions of accelerated bone turnover, including Paget's disease and osteoporosis; although in recent years, with the development of drugs that are more potent inhibitors of bone resorption, its use has declined. Read More

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January 2019

Leptin and its actions on reproduction in males.

Asian J Androl 2018 Dec 11. Epub 2018 Dec 11.

Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sg Buloh 47000, Selangor, Malaysia.

Leptin, an adipocyte-derived hormone, serves numerous physiological functions in the body, particularly during puberty and reproduction. The exact mechanism by which leptin activates the gonadotropin-releasing hormone (GnRH) neurons to trigger puberty and reproduction remains unclear. Given the widespread distribution of leptin receptors in the body, both central and peripheral mechanisms involving the hypothalamic-pituitary-gonadal axis have been hypothesized. Read More

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December 2018
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Severe hypercalcemia: A rare and unusual presentation of acute lymphoblastic leukemia.

J Cancer Res Ther 2018 Dec;14(Supplement):S1244-S1246

Division of Pediatric Hemato Oncology, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

Hypercalcemia is a rare and unusual complication of childhood malignancies. Acute lymphoblastic leukemia (ALL) presenting with hypercalcemia and lytic bone lesions is very rare in children. Here, we report a case of a 4-year-old girl with ALL who presented with severe hypercalcemia and radiological evidence of osteolytic lesions. Read More

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December 2018
4 Reads

Peripheral oxytocin and vasopressin modulates regional brain activity differently in men and women with schizophrenia.

Schizophr Res 2018 Dec 6;202:173-179. Epub 2018 Jul 6.

Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States of America; Department of Psychiatry, University of Cincinnati, United States of America.

Background: Oxytocin (OT) and arginine vasopressin (AVP) exert sexually dimorphic effects on cognition and emotion processing. Abnormalities in these hormones are observed in schizophrenia and may contribute to multiple established sex differences associated with the disorder. Here we examined sex-dependent hormone associations with resting brain activity and their clinical associations in schizophrenia patients. Read More

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December 2018

Survival Impact of Locoregional Treatment of the Primary Tumor in De Novo Metastatic Breast Cancers in a Large Multicentric Cohort Study: A Propensity Score-Matched Analysis.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Oncology, Claudius Regaud Institute, IUCT-Oncopole, Toulouse Cedex 09, France.

Introduction: Improvement in overall survival (OS) by locoregional treatment (LRT) of the primary tumor in de novo metastatic breast cancer (MBC) patients remains controversial.

Objective: The aim of our study was to evaluate the impact of LRT on OS in a large retrospective cohort of de novo MBC patients, with regard to immunohistochemical characteristics and pattern of metastatic dissemination.

Methods: We conducted a multicentric retrospective study of patients diagnosed with de novo MBC selected from the French Epidemiological Strategy and Medical Economics MBC database (NCT03275311) between 2008 and 2014. Read More

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December 2018

Abnormal Iodine Nutrition-Induced ER Stress Upregulates MCP-1 Expression Through P38/MAPK Signaling Pathway in Thyroid Cells.

Biol Trace Elem Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Endocrinology, The Second affiliated Hospital of Fujian Medical University, NO.34 North Zhongshan Road, Quanzhou City, Fujian Province, People's Republic of China.

Iodine is an important chemical for thyroid hormone synthesis. The association between iodine nutrition status and the risk of disease present U-shaped curve, as either low or high iodine nutrition status will increase the risk of thyroid diseases. Endoplasmic reticulum stress (ER stress), which can induce over expressions of inflammation factors, like monocyte chemo-attractant protein-1 (MCP-1), is related to the pathogenesis of thyroid disease. Read More

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December 2018

Invasive breast cancers in adolescent and young adult women show more aggressive immunohistochemical and clinical features than those in women aged 40-44 years.

Breast Cancer 2018 Dec 11. Epub 2018 Dec 11.

Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Background: Limited knowledge exists concerning the clinicopathological features of breast cancers (BCs) occurring in adolescent and young adult (AYA) women. We evaluated tumor characteristics in AYA women in comparison with those in middle-aged premenopausal women.

Methods: From consecutive AYA patients (< 35-year-old) with invasive BC in a single institute, 82 patients first treated with surgery were examined. Read More

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December 2018

My best case: homeopathic management of adverse effects of tamoxifen.

Wien Med Wochenschr 2018 Dec 11. Epub 2018 Dec 11.

General Practice Department, Faculty of Medicine, Strasbourg University, Strasbourg, France.

Background: Nearly half of patients discontinue tamoxifen hormone therapy early because of side effects, thus increasing the risk of breast cancer recurrence. Could a homeopathic treatment improve compliance?

Methods: A patient suffering from side effects of tamoxifen was seen in consultation every 2 months for 10 months by a senior homeopathic doctor and a registrar.

Results: Case analysis and repertorisation led to the identification of Pulsatilla as the simillimum drug and tamoxifen 7c as the etiological treatment. Read More

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December 2018

Reproductive and menopausal factors and risk of second primary breast cancer after in situ breast carcinoma.

Cancer Causes Control 2018 Dec 11. Epub 2018 Dec 11.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., M4-C308, Seattle, WA, 98109, USA.

Purpose: In situ breast cancer patients have a higher risk of developing a second primary breast cancer than women in the general population have of developing breast cancer. We have limited understanding of why some women with a previous in situ breast cancer develop second primary breast cancers while others do not.

Methods: In this population-based nested case-control study, we evaluated the association between reproductive and menopausal factors and risk of developing a second primary breast cancer among women with a previous in situ breast cancer. Read More

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December 2018

Combination therapy with parathyroid hormone analogs and antiresorptive agents for osteoporosis: a systematic review and meta-analysis of randomized controlled trials.

Osteoporos Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Spine Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Road, Harbin, Heilongjiang, 150001, People's Republic of China.

Combination therapy with parathyroid hormone (PTH) analogs and antiresorptive agents may be more effective than monotherapy for the treatment of osteoporosis. This study aimed to estimate the effectiveness and safety of this combination therapy for osteoporosis. MEDLINE, EMBASE, and Cochrane Library were searched from inception to May 1, 2018, including randomized controlled trials (RCTs) with a duration of at least 6 months on adults with osteoporosis treated with combination therapy versus monotherapy. Read More

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December 2018

Metabolic and Performance Responses to Sprint Exercise under Hypoxia among Female Athletes.

Sports Med Int Open 2018 Jun 22;2(3):E71-E78. Epub 2018 Aug 22.

Ritsumeikan University, Faculty of Sport and Health Science, Kusatsu, Japan.

The present study determined metabolic and performance responses to repeated sprint exercise under hypoxia among female team-sport athletes. Fifteen female athletes (age, 20.7±0. Read More

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Wearing Colored Glasses can Influence Exercise Performance and Testosterone concentration?

Sports Med Int Open 2018 Apr 5;2(2):E46-E51. Epub 2018 Jun 5.

Human Performance and Sport Research Group, Department of Sport Science/Institute of Health Sciences, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.

Perception of red color is associated with higher testosterone concentration and better human performance. Thus, we evaluated the acute effects of wearing colored-lens glasses on the YoYo intermittent endurance exercise test 2 (YoYoIE2) performance indicators and testosterone concentration. Ten soccer players performed three YoYoIE2 (counterbalanced crossover) wearing colorless (control), blue- or red-lensed glasses (2-4 days of rest in between). Read More

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Reference Intervals of Thyroid Hormones and Correlation of BMI with Thyroid Function in Healthy Zhuang Ethnic Pregnant Women.

Biomed Res Int 2018 14;2018:2032413. Epub 2018 Nov 14.

Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China.

Ethnic differences in the level of thyroid hormones exist among individuals. The American Thyroid Association (ATA) recommends that an institution or region should establish a specific thyroid hormone reference value for each stage of pregnancy. To date, a limited number of studies have reported the level of thyroid hormones in Chinese minorities, and the exact relationship between BMI and thyroid function in pregnant women is ill. Read More

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November 2018

Retrospective Analysis of Patients With Prostate Cancer Initiating GnRH Agonists/Antagonists Therapy Using a German Claims Database: Epidemiological and Patient Outcomes.

Front Oncol 2018 27;8:543. Epub 2018 Nov 27.

Department of Urology, University Hospital Schleswig-Holstein, Luebeck, Germany.

The objective of this study was to obtain real-world information on gonadotropin-releasing hormone agonist/antagonist (GnRHa) therapy in patients with advanced prostate cancer (PCa). Anonymized, routine healthcare claims data from approx. 75 German statutory health insurance funds from 2010-2015 ( = 4,205,227) were analyzed. Read More

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November 2018

A retrospective analysis of the follicle-stimulating hormone starting dose in expected normal responders undergoing their first fertilization cycle: proposed dose versus empiric dose.

Clin Exp Reprod Med 2018 Dec 30;45(4):183-188. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.

Objective: The purpose of this retrospective study was to evaluate the appropriateness of various follicle-stimulating hormone (FSH) starting doses in expected normal responders based on the nomogram developed by La Marca et al.

Methods: A total of 117 first fertilization cycles performed from 2011 to 2017 were selected. All women were expected normal responders and used a recombinant FSH and flexible gonadotropin-releasing hormone antagonist protocol. Read More

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December 2018

Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice ().

Clin Exp Reprod Med 2018 Dec 30;45(4):163-169. Epub 2018 Nov 30.

American Center for Reproductive Medicine, Urological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. Read More

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December 2018

Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells.

Clin Exp Reprod Med 2018 Dec 30;45(4):154-162. Epub 2018 Nov 30.

Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Objective: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3 (TLR3), as a part of the innate immune system, plays an important role in detecting viral infections. Read More

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December 2018

Evaluation of Hot Nodules of Thyroid Gland Using Tc-99m Pertechnetate: a Novel Approach Using Quantitative Single-Photon Emission Computed Tomography/Computed Tomography.

Nucl Med Mol Imaging 2018 Dec 3;52(6):468-472. Epub 2018 Nov 3.

1Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 13620 South Korea.

Planar scintigraphy using Tc-99m pertechnetate is useful for snapshot evaluation of hot thyroid nodules, which are pathologically follicular adenoma and seldom, if ever, malignant. The autonomy of the hot nodules has been demonstrated by the presence of thyroid-stimulating hormone-dependent extra-nodular thyroid tissue besides the hot nodules. Here, we present two cases of hot thyroid nodules in patients who underwent quantitative single-photon emission computed tomography/computed tomography (SPECT/CT). Read More

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December 2018

Transcutaneous Electrical Acupoint Stimulation Accelerates the Recovery of Gastrointestinal Function after Cesarean Section: A Randomized Controlled Trial.

Evid Based Complement Alternat Med 2018 13;2018:7341920. Epub 2018 Nov 13.

Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.

Background: Gastrointestinal functional recovery is an important factor affecting postoperative outcome. The aim of this study was to evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on gastrointestinal function in women undergoing cesarean section.

Methods: 150 pregnant women undergoing cesarean section were randomly allocated into TEAS, nonacupoint stimulation (sham group), and no stimulation (control group). Read More

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November 2018

A Classic Herbal Formula Danggui Beimu Kushen Wan for Chronic Prostatitis: From Traditional Knowledge to Scientific Exploration.

Evid Based Complement Alternat Med 2018 13;2018:1612948. Epub 2018 Nov 13.

School of Health and Biomedical Sciences, RMIT University, Australia.

Chronic prostatitis (CP) is a chronic inflammation in the prostate with unsatisfactory management. Danggui Beimu Kushen Wan (DBKW) is a classic formula developed 1800 years ago for patients with difficult urination and it has been widely utilized for CP in modern days. However, scientific understanding of DBKW on CP has not been systematically reviewed. Read More

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November 2018

Rust Infection of Black Poplar Trees Reduces Photosynthesis but Does Not Affect Isoprene Biosynthesis or Emission.

Front Plant Sci 2018 27;9:1733. Epub 2018 Nov 27.

Department of Biochemistry, Max Planck Institute for Chemical Ecology, Jena, Germany.

Poplar ( spp.) trees are widely distributed and play an important role in ecological communities and in forestry. Moreover, by releasing high amounts of isoprene, these trees impact global atmospheric chemistry. Read More

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November 2018

Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes.

Front Endocrinol (Lausanne) 2018 27;9:687. Epub 2018 Nov 27.

Nutrigenomics and Fish Growth Endocrinology, Institute of Aquaculture Torre de la Sal (IATS-CSIC), Castellón, Spain.

The Gh/Prl/Sl family has evolved differentially through evolution, resulting in varying relationships between the somatotropic axis and growth rates within and across fish species. This is due to a wide range of endogenous and exogenous factors that make this association variable throughout season and life cycle, and the present minireview aims to better define the nutritional and environmental regulation of the endocrine growth cascade over precisely defined groups of fishes, focusing on Mediterranean farmed fishes. As a result, circulating Gh and Igf-i are revitalized as reliable growth markers, with a close association with growth rates of gilthead sea bream juveniles with deficiency signs in both macro- or micro-nutrients. Read More

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November 2018

Incidence and prognostic factors of patients with synchronous liver metastases upon initial diagnosis of breast cancer: a population-based study.

Cancer Manag Res 2018 20;10:5937-5950. Epub 2018 Nov 20.

Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China,

Background: The purpose of this study was to analyze the incidence and prognostic factors of patients with breast cancer liver metastases (BCLM) at initial diagnosis.

Methods: We utilized the Surveillance, Epidemiology, and End Results database to extract data on patients with primary invasive breast cancer from 2010 to 2014. Multivariate logistic regression was conducted to determine factors associated with the presence of liver metastases upon initial diagnosis of breast cancer. Read More

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November 2018
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Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases.

Breast Cancer (Dove Med Press) 2018 23;10:195-199. Epub 2018 Nov 23.

Department of Breast Surgery, Breast Center, Kameda Medical Center, Chiba, Japan,

Background: Identification of the proteins that are associated with estrogen receptor (ER) status is a first step in selecting drugs against hormone-dependent breast cancer. Recently, the proteins associated with ER status were reported using liquid chromatography and tandem mass spectrometry, and microRNA (miRNA) profiling of breast cancer subtype was demonstrated using real-time-PCR.

Methods: We present herein two cases with differential protein expression and miRNA profiling in ER-positive and -negative breast cancer. Read More

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November 2018

Prognostic significance of mammary Paget's disease in Chinese women: a 10-year, population-based, matched cohort study.

Onco Targets Ther 2018 23;11:8319-8326. Epub 2018 Nov 23.

Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China,

Purpose: To explore the prognostic significance of mammary Paget's disease (PD) in breast cancer (BC) patients and to investigate the association between clinical manifestation and outcome in invasive ductal carcinoma patients with PD (PD-IDC).

Patients And Methods: Eighty-five patients diagnosed with mammary PD with underlying BC from 2006 to 2012 at Zhejiang Cancer Hospital were recruited. A matched group comprised 85 patients diagnosed with BC without PD. Read More

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November 2018
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Childhood-onset growth hormone deficiency and the transition to adulthood: current perspective.

Ther Clin Risk Manag 2018 23;14:2283-2291. Epub 2018 Nov 23.

Development Endocrinology Research Group, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK,

Childhood-onset growth hormone deficiency (CO-GHD) is an endocrine condition associated with a broad range of health issues from childhood through to adulthood, which requires particular attention during the transition period from adolescence to young adulthood. There is uncertainty in the clinical practice of the management of CO-GHD during transition regarding the clinical assessment and management of individual patients during and after transition to obtain optimal follow-up and improved health outcomes. Despite the availability of clinical guidelines providing the framework for transition of young adults with CO-GHD, there remains substantial variation in approaching transitional care among pediatric and adult services. Read More

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November 2018

Decapeptide functionalized targeted mesoporous silica nanoparticles with doxorubicin exhibit enhanced apoptotic effect in breast and prostate cancer cells.

Int J Nanomedicine 2018 19;13:7669-7680. Epub 2018 Nov 19.

Nanobioscience Group, Agharkar Research Institute, Pune, India,

Background: Considering the increase in cancer cases and number of deaths per year worldwide, development of potential therapeutics is imperative. Mesoporous silica nanoparticles (MSNPs) are among the potential nanocarriers having unique properties for drug delivery. Doxorubicin (DOX), being the most commonly used drug, can be efficiently delivered to gonadotropin-releasing hormone (GnRH)-overexpressing cancer cells using functionalized MSNPs. Read More

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November 2018

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma.

Oncogene 2018 Dec 11. Epub 2018 Dec 11.

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, a.k.a. Read More

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December 2018

Biliopancreatic diversion with duodenal switch (BPD-DS) and single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) result in distinct post-prandial hormone profiles.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Unit for Multidisciplinary Research in Biomedicine (UMIB), Endocrine, Cardiovascular and Metabolic Research, University of Porto, Porto, Portugal.

Background/objective: Biliopancreatic diversion with duodenal switch (BPD-DS) is the most effective bariatric intervention to treat morbid obesity and related disorders. Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) is a new bariatric procedure devised with the purpose of simplifying the complexity of the BPD-DS technique while maintaining its efficacy. However, whether BPD-DS and SADI-S result in similar fasting and post-prandial hormone profiles has not yet been studied. Read More

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December 2018

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5020, Bergen, Norway.

Objective: A causal obesity risk variant in the FTO locus was recently shown to inhibit adipocyte thermogenesis via increased adipose expression of the homeobox transcription factors IRX3 and IRX5. However, causal effects of IRX5 on fat storage remain to be shown in vivo, and discovery of downstream mediators may open new therapeutic avenues.

Methods: 17 WT and 13 Irx5 knockout (KO) mice were fed low-fat control (Ctr) or high-fat (HF) diet for 10 weeks. Read More

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December 2018

RNA-mediated gene fusion in mammalian cells.

Proc Natl Acad Sci U S A 2018 Dec 11. Epub 2018 Dec 11.

Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030;

One of the hallmarks of cancer is the formation of oncogenic fusion genes as a result of chromosomal translocations. Fusion genes are presumed to form before fusion RNA expression. However, studies have reported the presence of fusion RNAs in individuals who were negative for chromosomal translocations. Read More

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December 2018

Hydraulics regulates stomatal responses to changes in leaf water status in Athyrium filix-femina.

Plant Physiol 2018 Dec 11. Epub 2018 Dec 11.

Purdue University CITY: West Lafayette STATE: IN POSTAL_CODE: 47906 United States Of America [US]

Stomatal responses to changes in leaf water status are important for the diurnal regulation of gas exchange and the survival of plants during drought. These stomatal responses in angiosperm species are well characterized, yet an ongoing debate surrounds the role of metabolism, particularly the role of the hormone abscisic acid (ABA), in functionally regulating stomatal responses to changes in leaf water status in species of non-seed plants. Here we measured the stomatal response to changes in vapour pressure deficit (VPD) in two natural forms of the fern species Athyrium filix-femina, recently suggested to have stomata that are regulated by ABA. Read More

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December 2018

Use of Novel Combination Therapies in the Treatment of Advanced HR+/HER2- Breast Cancer.

Authors:

J Natl Compr Canc Netw 2018 Dec;16(suppl 1):S5-S17

Endocrine therapy remains the backbone for treatment of hormone receptor-positive breast cancer in the metastatic setting. Despite the effectiveness of endocrine therapy, primary and acquired endocrine resistance continue to be important clinical challenges. The landscape of metastatic breast cancer treatment has changed considerably with the incorporation of novel agents, including cyclin-dependent kinase 4/6 and mammalian target of rapamycin inhibitors. Read More

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December 2018

Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial.

Nutr Metab Cardiovasc Dis 2018 Jul 17. Epub 2018 Jul 17.

Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Aims: Polycystic Ovarian Syndrome is a common reproductive, endocrine, and metabolic disease in women. Pomegranate juice, known as a rich source of phytochemicals with high antioxidant activity, enriched with probiotic may improve PCOS.

Methods And Results: A randomized, controlled, triple-blinded, parallel trial study was performed in PCOS patients (n = 92). Read More

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Physical and physiological demands and hormonal responses in basketball small-sided games with different tactical tasks and training regimes.

J Sci Med Sport 2018 Nov 23. Epub 2018 Nov 23.

Lithuanian Sports University, Institute of Sport Science and Innovations, Lithuania.

Objectives: To evaluate external and internal training load (TL) and hormonal responses in basketball 3-versus-3 small-sided games (SSGs).

Design: Randomized repeated-measures study.

Methods: Twelve male basketball players participated to four 3-versus-3 SSGs characterized by different tactical tasks (offensive; defensive) and training regimes (long-intermittent: three 4-min bouts with 2' rest in between; short-intermittent: six 2-min bouts with 1' rest in between). Read More

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November 2018

Evaluation estrogen, progesteron and androgen receptor expressions in corneal epithelium in keratoconus.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Hacettepe University, Bioengineering, Ankara, Turkey.

Purpose: To evaluate the role of sex steroid hormone receptors in corneal epithelium in etiopathogenesis of keratoconus (KC).

Methods: Thirty patients with KC who were planned for corneal collagen-crosslinking and 20 patients who were planned for excimer laser for refractive errors included in this study. Corneal epitheliums were curated mechanically during surgeries. Read More

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December 2018

Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise.

Biochem Biophys Res Commun 2018 Dec 8. Epub 2018 Dec 8.

Department of Nutrition, Food and Exercise Science, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, 600 W. College Avenue, Tallahassee, FL, 32306, USA. Electronic address:

Exercise increases skeletal muscle health in part by altering the types of genes that are transcribed. Previous work suggested that glucocorticoids signal through the protein Regulated in Development and DNA Damage 1 (REDD1) to regulate gene expression following acute aerobic exercise. The present study shows that expression of the core clock gene, Period1, is among those modulated by the glucocorticoid-REDD1 signaling pathway in skeletal muscle. Read More

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December 2018

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke.

J Neuroinflammation 2018 Dec 11;15(1):339. Epub 2018 Dec 11.

Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, China.

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx. Read More

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December 2018

Idiopathic calcinosis cutis of the scrotum: a case report and review of the literature.

J Med Case Rep 2018 Dec 12;12(1):366. Epub 2018 Dec 12.

Department of Dermatology and Venereology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.

Background: Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. Idiopathic calcinosis cutis of the scrotum is an uncommon entity. The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. Read More

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December 2018
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