57,634 results match your criteria Hormonal Therapy


The new place of enterohormones in intestinal failure.

Curr Opin Clin Nutr Metab Care 2020 Jun 28. Epub 2020 Jun 28.

Department of Gastroenterology and Nutritional Support, Center for Intestinal Failure, Reference Centre of Rare Disease MarDI, AP-HP Beaujon Hospital, University of Paris Inserm UMR 1149, Paris, France.

Purpose Of Review: As the approval of teduglutide, a glucagon-like peptide-2 (GLP-2) analog, for the treatment of patients with short bowel syndrome (SBS) associated with intestinal failure, enterohormone therapy has received significant interest and is becoming the first choice of treatment in selected patients. As such, it is paramount to assess and understand the new place of hormonal therapy in the algorithm of treatments in SBS-intestinal failure.

Recent Findings: Specialized intestinal failure units have recently reported their outcomes with teduglutide to evaluate if they are consistent with the phase III trials results. Read More

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http://dx.doi.org/10.1097/MCO.0000000000000672DOI Listing

Innovative approach to a functional mediastinal paraganglioma with anomalous coronary supply: a case report.

Eur Heart J Case Rep 2020 Jun 17;4(3):1-6. Epub 2020 Apr 17.

Cardiology Unit, Centro Hospitalar Universitário do Porto, Largo do Prof. Abel Salazar, 4099-001 Porto, Portugal.

Background: Mediastinal paragangliomas (PGs) are rare and particularly challenging neuroendocrine tumours. Clinical presentation is heterogeneous and tumour resection can be challenging due to bleeding and the risk of catecholamine surges in functional tumours.

Case Summary: A 36-year-old man with multiple cardiovascular risk factors was admitted with subacute heart failure. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319854PMC

Neurobiological biomarkers of response to ketamine.

Adv Pharmacol 2020 18;89:195-235. Epub 2020 Jun 18.

Section on the Neurobiology and Treatment of Mood Disorders, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.

As a field, psychiatry is undergoing an exciting paradigm shift toward early identification and intervention that will likely minimize both the burden associated with severe mental illnesses as well as their duration. In this context, the rapid-acting antidepressant ketamine has revolutionized our understanding of antidepressant response and greatly expanded the pharmacologic armamentarium for treatment-resistant depression. Efforts to characterize biomarkers of ketamine response support a growing emphasis on early identification, which would allow clinicians to identify biologically enriched subgroups with treatment-resistant depression who are more likely to benefit from ketamine therapy. Read More

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http://dx.doi.org/10.1016/bs.apha.2020.05.003DOI Listing

Deciphering short stature in children.

Ann Pediatr Endocrinol Metab 2020 Jun 30;25(2):69-79. Epub 2020 Jun 30.

Department of Pediatrics, University of Chieti, Chieti, Italy.

Short stature is a common reason for referral to pediatric endocrinologists. Multiple factors, including genetic, prenatal, postnatal, and local environmental factors, can impair growth. The majority of children with short stature, which can be defined as a height less than 2 standard deviation score below the mean, are healthy. Read More

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http://dx.doi.org/10.6065/apem.2040064.032DOI Listing

Are the Effects of Oral and Vaginal Contraceptives on Bone Formation in Young Women Mediated via the Growth Hormone-IGF-I Axis?

Front Endocrinol (Lausanne) 2020 16;11:334. Epub 2020 Jun 16.

Department of Kinesiology, Pennsylvania State University, University Park, PA, United States.

Combined hormonal contraceptive therapy has been associated with negative bone mineral density outcomes that may be route-dependent [i.e., combined oral contraception (COC) vs. Read More

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http://dx.doi.org/10.3389/fendo.2020.00334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309348PMC

Modern Radiation Therapy for Pituitary Adenoma: Review of Techniques and Outcomes.

Neurol India 2020 May-Jun;68(Supplement):S113-S122

Department of Radiation Oncology; Department of Neuro-Oncology Disease Management Group, TMH/ACTREC, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, Maharashtra, India.

Pituitary adenomas are benign tumors arising in the adenohypophysis and comprise 8%-20% of all reported primary brain tumors in the west. Transsphenoidal surgery with an aim to achieve complete tumor resection is the recommended first-line treatment for nonfunctioning as well as secretory pituitary adenoma. External beam radiation therapy (RT) has been demonstrated to be an effective treatment modality for pituitary adenoma, uncured by surgery and/or medical therapy, providing excellent long-term local control (>90%), but lower and variable rates (50%-80%) of biochemical remission in secretory tumors. Read More

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http://dx.doi.org/10.4103/0028-3886.287678DOI Listing

Pituitary Apoplexy: A Comprehensive Review.

Neurol India 2020 May-Jun;68(Supplement):S72-S78

Department of Neurosurgery, Devadoss Hospital, Madurai, Tamil Nadu, India.

Pituitary apoplexy (PA) is a rare, usually vision-threatening and occasionally life-threatening entity. The exact incidence of PA in large series of pituitary adenomas is variable; however, it is more common in macroadenomas and nonfunctioning adenomas though it has been reported rarely in microadenomas. There are several well-known precipitating factors for PA including the use of anticoagulants, surgery, head trauma, pregnancy, etc. Read More

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http://dx.doi.org/10.4103/0028-3886.287669DOI Listing

In Vitro Assessment of Homeopathic Potencies of Hydrastis canadensis on Hormone-Dependent and Independent Breast Cancer.

Homeopathy 2020 Jul 1. Epub 2020 Jul 1.

Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Uttar Pradesh, India.

Background:  Breast cancer is the second leading cause of cancer-related deaths in women. Conventional treatment such as chemotherapy, hormonal therapy and radiotherapy has decreased the mortality rate among cancer patients but has also revealed long-term side effects. Drug resistance and toxicity to normal cells compound the problems associated with the use of modern medicines. Read More

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http://dx.doi.org/10.1055/s-0040-1709668DOI Listing

Efficacy and Safety of Androgen-Deprivation Therapy Combined with Docetaxel Plus Prednisone in High-Burden Metastatic Hormone-Sensitive Prostate Cancer.

Cancer Manag Res 2020 9;12:4369-4377. Epub 2020 Jun 9.

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

Purpose: The aim of this study was to evaluate the efficacy and safety of hormonal and synchronous docetaxel plus prednisone (DocP) in metastatic hormone-sensitive prostate cancer (mHSPC).

Methods: One hundred fifty-one cases with high-burden mHSPC diagnosed at 1 single center from January 2014 to August 2018 were analyzed retrospectively. Among them, 85 cases received androgen-deprivation therapy (ADT) within 3 months, along with 6 cycles of docetaxel + prednisone (treatment group), whereas 66 received ADT alone (control group). Read More

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http://dx.doi.org/10.2147/CMAR.S243843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293408PMC

Sparing the hippocampus and the hypothalamic- pituitary region during whole brain radiotherapy: a volumetric modulated arc therapy planning study.

BMC Cancer 2020 Jun 30;20(1):610. Epub 2020 Jun 30.

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Background: Feasibility testing of a simultaneous sparing approach of hippocampus, hypothalamus and pituitary gland in patients undergoing whole-brain radiotherapy (WBRT) with and without a concomitant boost to metastatic sites.

Introduction: Cognitive impairment and hormonal dysfunction are common side effects of cranial radiotherapy. A reduced dose application to the patho-physiologically involved functional brain areas, i. Read More

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http://dx.doi.org/10.1186/s12885-020-07091-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325372PMC

Symptom Profiles of Latina Breast Cancer Survivors: A Latent Class Analysis.

Nurs Res 2020 Jul/Aug;69(4):264-271

Tracy E. Crane, PhD, RDN, is Assistant Professor, University of Arizona, Tucson. Terry A. Badger, PhD, RN, PMHCNS-BC, FAAN, is Professor, University of Arizona, Tucson. Alla Sikorskii, PhD, is Professor, Michigan State University, East Lansing. Chris Segrin, PhD, is Professor, University of Arizona, Tucson. Chiu-Hsieh Hsu, PhD, is Professor, University of Arizona, Tucson. Anne G. Rosenfeld, PhD, RN, CNS, FAHA, FAAN, is Professor, University of Arizona, Tucson.

Background: Symptom research among Latinas with breast cancer is limited-especially as it relates to multiple co-occurring symptoms.

Objective: The aim of the study was to identify subgroups (latent classes) of Latinas who have distinct symptom profiles while receiving radiation, chemotherapy, and/or hormonal therapy for breast cancer.

Methods: This secondary analysis included intake data from three randomized trials of supportive care psychosocial interventions for Latinas treated for breast cancer (n = 290). Read More

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http://dx.doi.org/10.1097/NNR.0000000000000434DOI Listing

Is There Any Role for 18F-Fluciclovine PET/CT in the Presence of Undetectable PSA in Prostate Cancer Patients After Definitive Treatment?

Clin Nucl Med 2020 Jun 25. Epub 2020 Jun 25.

From the Division of Diagnostic Imaging, Department of Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: The aim of this study was to investigate the role of F-fluciclovine PET/CT in the evaluation of prostate cancer (PC) patients after definitive treatment in the presence of undetectable prostate-specific antigen (PSA).

Patients And Methods: This retrospective study was conducted in PC patients who had undetectable PSA level and underwent fluciclovine PET/CT within a 2-week interval of PSA examination and without interval treatment or other cancer. Patient and tumor characteristics at initial diagnosis, treatment regimens, and findings on fluciclovine PET/CT were collected. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003122DOI Listing

Prognostic Significance of Circulating CD28 Negative Suppressor T Cells and Memory B Cells in Patients with Breast Cancer.

Iran J Immunol 2020 Jun;17(2):95-110

Clinical Pathology Department, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: It has been suggested that routine assessment and quantification of different lymphocyte subsets can provide clinically meaningful prognostic information in breast cancer (BC).

Objective: To determine the relationship between peripheral blood lymphocyte subsets and pathological parameters and response to therapy in patients with BC.

Methods: Thirty patients with operable breast cancer treated surgically with either modified radical mastectomy or breast conservative surgery, and 20 healthy controls were included. Read More

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http://dx.doi.org/10.22034/iji.2020.83420.1625DOI Listing

Management and outcome of metastatic pheochromocytomas/paragangliomas: an overview.

J Endocrinol Invest 2020 Jun 29. Epub 2020 Jun 29.

Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, Florence, Italy.

Background: Metastatic pheochromocytomas and paragangliomas (PPGLs) occur in about 5-26% of cases and are characterized by a heterogeneous prognosis. Metastases can be synchronous at the initial diagnosis, but they can occur also many years after surgery for the primary tumor. To date, the treatment of patients affected by metastatic PPGLs represents a clinical challenge because of the lack of guidelines. Read More

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http://dx.doi.org/10.1007/s40618-020-01344-zDOI Listing

Adherence to adjuvant endocrine therapy among breast cancer survivors: a systematic review and meta-synthesis of the qualitative literature using grounded theory.

Support Care Cancer 2020 Jun 29. Epub 2020 Jun 29.

Department of Pharmacy, University of Reading, PO Box 226, Whiteknights, Reading, Berkshire, RG6 6AP, UK.

Purpose: Numerous studies have examined non-adherence to adjuvant endocrine therapy in women recovering from breast cancer, but none provides a comprehensive theory to explain the challenges of long-term medication taking and resilience needed to continue. The aim of this study was to source, appraise, and synthesize data from existing qualitative studies to develop an in-depth explanatory model of non-adherence and discontinuation of hormonal medication among breast cancer survivors.

Methods: A comprehensive search of databases and the literature identified 24 eligible qualitative studies published 2010-2019. Read More

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http://dx.doi.org/10.1007/s00520-020-05585-9DOI Listing

The Role Of Nano- Ophthalmology In Treating Dry Eye Disease.

Pharm Nanotechnol 2020 Jun 27. Epub 2020 Jun 27.

College of Pharmacy and Health Sciences, Ajman University, Ajman. United Arab Emirates.

Dry eye disease (DED) is a common multifactorial disease linked to the tears/ocular surface leading to eye discomfort, ocular surface damage, and visual disturbance. Anti-inflammatory agents (steroids and cyclosporine A), hormonal therapy, antibiotics, nerve growth factors, essential fatty acids are used as treatment options of DED. Current therapies attempt to reduce the ocular discomfort by producing lubrication and stimulating gland/nerve(s) associated with tear production, without providing a permanent cure for dry eye. Read More

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http://dx.doi.org/10.2174/2211738508666200628034227DOI Listing

Integrating the Tumor Microenvironment into Cancer Therapy.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Low Prevalence Tumors, Centro de investigación biomédica en red de cáncer (CIBERONC), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Tumor progression is mediated by reciprocal interaction between tumor cells and their surrounding tumor microenvironment (TME), which among other factors encompasses the extracellular milieu, immune cells, fibroblasts, and the vascular system. However, the complexity of cancer goes beyond the local interaction of tumor cells with their microenvironment. We are on the path to understanding cancer from a systemic viewpoint where the host macroenvironment also plays a crucial role in determining tumor progression. Read More

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http://dx.doi.org/10.3390/cancers12061677DOI Listing

Early Adaptive Thermogenesis Is a Determinant of Weight Loss after Six Weeks of Caloric Restriction in Overweight Subjects.

Metabolism 2020 Jun 26:154303. Epub 2020 Jun 26.

Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 4212 North 16(th) Street, Phoenix, AZ 85016, USA; Department of Information Engineering, University of Pisa, Pisa 56122, Italy. Electronic address:

Background: Adaptive thermogenesis during prolonged energy deficit refers to the greater than expected reduction in energy expenditure (EE) independent of concomitant loss of metabolically active body mass.

Objective: As inter-individual variability in the magnitude of adaptive thermogenesis may influence the extent of energy deficit thereby predicting the amount of weight reduction, we investigated whether early adaptive thermogenesis is a determinant of weight loss after 6 weeks of daily 50% caloric restriction in an inpatient setting.

Design And Methods: The current study report the results of an exploratory, secondary analysis in overweight but otherwise healthy subjects (n = 11, 7 men, 35 ± 9y, BMI = 40 ± 7 kg/m, body fat = 63. Read More

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http://dx.doi.org/10.1016/j.metabol.2020.154303DOI Listing

Osteopathic Manipulative Treatment and Psychosocial Management of Dysmenorrhea.

J Am Osteopath Assoc 2020 Jul;120(7):479-482

Dysmenorrhea, or painful menstruation, is a common cause of acute pelvic pain that affects approximately two-thirds of women who are postmenarchal in the United States. Dysmenorrhea pain is frequently severe enough to disrupt daily activities and often accompanied by other symptoms, such as diarrhea, nausea, vomiting, headache, and dizziness. Primary dysmenorrhea is likely due to an excess of prostaglandins and is traditionally treated with nonsteroidal anti-inflammatory drugs and hormonal therapy. Read More

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http://dx.doi.org/10.7556/jaoa.2020.076DOI Listing

Tolerability considerations for gonadotropin-releasing hormone analogues for endometriosis.

Expert Opin Drug Metab Toxicol 2020 Jun 27. Epub 2020 Jun 27.

Department of Public Health, School of Medicine, University of Naples Federico II , Naples, Italy.

Introduction The second-line treatment of endometriosis-related pain symptoms includes injectable depot formulations of gonadotropin-releasing hormone analogs (GnRH-as). These drugs improve the symptomatology by inducing a hypoestrogenic status and a consequent regression of endometriotic implants. However, GnRH-a may cause a not negligible rate of adverse events, in particular vasomotor symptoms and bone mineral density loss, that may limit patients' adherence and safety on long-term treatment. Read More

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http://dx.doi.org/10.1080/17425255.2020.1789591DOI Listing

Using Artificial Intelligence Resources in Dialysis and Kidney Transplant Patients: A Literature Review.

Biomed Res Int 2020 10;2020:9867872. Epub 2020 Jun 10.

"Grigore T. Popa" University of Medicine, Iasi, Romania.

Background: The purpose of this review is to depict current research and impact of artificial intelligence/machine learning (AI/ML) algorithms on dialysis and kidney transplantation. Published studies were presented from two points of view: What medical aspects were covered? What AI/ML algorithms have been used?

Methods: We searched four electronic databases or studies that used AI/ML in hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation (KT). Sixty-nine studies were split into three categories: AI/ML and HD, PD, and KT, respectively. Read More

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http://dx.doi.org/10.1155/2020/9867872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303737PMC

Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06).

J Breast Cancer 2020 Jun 21;23(3):314-319. Epub 2020 May 21.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311362PMC

Coronary Event Analysis in Breast Cancer Patients Who Received Breast-Conserving Surgery and Post-Operative Radiotherapy: a Korean Nationwide Cohort Study.

J Breast Cancer 2020 Jun 29;23(3):291-302. Epub 2020 Apr 29.

Review and Assessment Committee, Korean Health Insurance Review & Assessment Service, Wonju, Korea.

Purpose: Adjuvant breast radiotherapy (RT) following breast-conserving surgery (BCS) has been reported to induce cardiac toxicity in breast cancer patients. We investigated the incidence and risk factors of major coronary events after breast RT using Korean nationwide Health Insurance Review and Assessment data.

Methods: Using data from a nationwide quality assessment of breast cancer treatment, we identified 3,251 patients who received breast RT after BCS in 2013. Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311360PMC

Effects of Hormone Replacement Therapy on Bone Mass after Allogeneic Hematopoietic Stem Cell Transplantation.

J Clin Endocrinol Metab 2020 Jun 27. Epub 2020 Jun 27.

Division of Hematology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Context And Objectives: This study aimed to assess the effects of hormone replacement therapy (HRT) on bone mineral density (BMD) in young females who underwent allogeneic hematopoietic stem cell transplantation (HSCT).

Participants And methods: The retrospective cohort included 234 female patients with premature ovarian insufficiency (POI) who underwent allogeneic HSCT between April 2009 and April 2016 at Seoul St. Mary's Hospital in Seoul, Korea. Read More

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http://dx.doi.org/10.1210/clinem/dgaa406DOI Listing

Factors influencing adherence to adjuvant endocrine therapy in breast cancer-treated women: using real-world data to inform a switch from acute to chronic disease management.

Breast Cancer Res Treat 2020 Jun 26. Epub 2020 Jun 26.

Centre for Research on Health and Social Care Management (Cergas), SDA Bocconi School of Management, Milan, Italy.

Purpose: Adjuvant endocrine therapy (AET) for ≥ 5 years is generally recommended for women with hormone receptor-positive breast cancer to reduce cancer recurrence/mortality; however, adherence can be suboptimal. We tested determinants of AET adherence using patient characteristics, treatment pathways, AET initiation timing, and multiple healthcare facility use. An underlying objective was to explore how oncological pathways mirror chronic disease management to monitor adherence and target improvement interventions using administrative datasets. Read More

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http://dx.doi.org/10.1007/s10549-020-05748-6DOI Listing

Organ of hearing and balance in peri- and postmenopausal women. Effects of hormone replacement therapy on hearing and balance in peri- and post-menopausal women: The current state of knowledge.

Adv Clin Exp Med 2020 Jun;29(6):751-755

Department and Clinic of Otolaryngology Head and Neck Surgery, Wroclaw Medical University, Poland.

Sensory-neural hearing loss in people over 50 - senile deafness - is currently an increasing problem due to the growing proportion of the elderly people in the population. We can find a number of worldwide publications on hearing loss and dizziness in peri-menopausal women, but the data is inconsistent. Reports describing the influence of sex hormones on the ear and its aging are similarly controversial. Read More

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http://dx.doi.org/10.17219/acem/121935DOI Listing

A rapid volume of interest-based approach of radiomics analysis of breast MRI for tumor decoding and phenotyping of breast cancer.

PLoS One 2020 26;15(6):e0234871. Epub 2020 Jun 26.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Recently, radiomics has emerged as a non-invasive, imaging-based tissue characterization method in multiple cancer types. One limitation for robust and reproducible analysis lies in the inter-reader variability of the tumor annotations, which can potentially cause differences in the extracted feature sets and results. In this study, the diagnostic potential of a rapid and clinically feasible VOI (Volume of Interest)-based approach to radiomics is investigated to assess MR-derived parameters for predicting molecular subtype, hormonal receptor status, Ki67- and HER2-Expression, metastasis of lymph nodes and lymph vessel involvement as well as grading in patients with breast cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234871PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319601PMC

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver.

Oncogene 2020 Jun 25. Epub 2020 Jun 25.

Institute of Cancer Research, Medical University Vienna, Comprehensive Cancer Center, Vienna, Austria.

As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 is a paradigm of this. We investigated the functions of the most common GATA3 mutation (X308_Splice) and five additional mutations, which converge into a neoprotein that we called "neoGATA3," associated with excellent prognosis in patients. Read More

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http://dx.doi.org/10.1038/s41388-020-1376-3DOI Listing

Medical management of meningiomas.

Handb Clin Neurol 2020 ;170:291-302

Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States; Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, MA, United States. Electronic address:

Meningiomas are the most frequently occurring primary brain tumors in adults, representing almost one-third of all primary central nervous system tumors. Several factors have been suggested as an underlying cause in the development of meningiomas, such as ionizing radiation (therapeutic or other incidental exposure), hormonal factors, and genetic predisposition syndromes. Other established factors associated with meningiomas include age, female gender, and those from non-Hispanic Black backgrounds. Read More

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http://dx.doi.org/10.1016/B978-0-12-822198-3.00048-3DOI Listing
January 2020

Opening large-conductance potassium channels selectively induced cell death of triple-negative breast cancer.

BMC Cancer 2020 Jun 26;20(1):595. Epub 2020 Jun 26.

Department of Physiology & Pharmacology, West Virginia University, Morgantown, WV, 26506, USA.

Background: Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective targets for triple-negative breast cancer (TNBC). It has recently been recognized that membrane potential is depolarized in breast cancer cells. The primary objective of the study is to explore whether hyperpolarization induced by opening potassium channels may provide a new strategy for treatment of TNBC. Read More

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http://dx.doi.org/10.1186/s12885-020-07071-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318490PMC

Effects of postoperative medical treatment and expectant treatment on dysmenorrhea after conservative laparoscopic surgery for deep-infiltrating endometriosis accompanied by dysmenorrhea.

J Int Med Res 2020 Jun;48(6):300060520931666

Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To compare the efficacy of postoperative adjuvant treatment (gonadotropin-releasing hormone agonists [GnRHas] and oral contraceptives [OCs]) and expectant treatment in preventing recurrent dysmenorrhea following conservative laparoscopic surgery for deep infiltrating endometriosis (DIE) with dysmenorrhea.

Methods: A prospective cohort study was conducted in Shanghai, China. In total, 147 patients with dysmenorrhea who underwent conservative laparoscopic surgery for DIE were enrolled. Read More

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http://dx.doi.org/10.1177/0300060520931666DOI Listing

UN-RIPED fruit pods of Prosopis cineraria (L.) Druce ameliorates cisplatin theraphy induced partial testicular atrophy in MALE Wistar rats.

J Ethnopharmacol 2020 Jun 22:113070. Epub 2020 Jun 22.

SRM College of Pharmacy, SRM Institute of Science and Technology (Formerly SRM University), Kattangulathur, Kancheepuram dist, Chennai, 603203, India. Electronic address:

Ethnopharmacological Relevance: Prosopis cineraria (L.) Druce is a plant that is widely found in dry parts of India. The unripe fruit pod has a very specific traditional claim of treating male infertility and increasing the sperm volume and count. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113070DOI Listing

Prostatic hyperplasia: Vascularization, hemodynamic and hormonal analysis of dogs treated with finasteride or orchiectomy.

PLoS One 2020 25;15(6):e0234714. Epub 2020 Jun 25.

Department of Animal Reproduction, Faculty of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.

As a consequence of a hormonal imbalance, Prostatic Hyperplasia (PH) is characterized by increased prostate volume, along with higher local angiogenesis and vascularization. Orchiectomy is the common treatment for dogs, however it is not an option for breeding animals. Thus, finasteride arises as the drug of choice for stud dogs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234714PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316311PMC

Long-term clinical outcomes of salvage pelvic radiation therapy for oligo-recurrent pelvic lymph nodes after definitive external-beam radiation therapy for non-metastatic prostate cancer.

J Radiat Res 2020 Jun 25. Epub 2020 Jun 25.

Department of Radiation Oncology and Image-applied Therapy, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507 Japan.

Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage pelvic radiation therapy (sPRT) for oligo-recurrent pelvic lymph nodes after definitive EBRT for non-metastatic PCa. Patients who developed PeNR after definitive EBRT and were subsequently treated with sPRT at our institution between November 2007 and December 2015 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1093/jrr/rraa044DOI Listing

Liraglutide: New Perspectives for the Treatment of Polycystic Ovary Syndrome.

Clin Drug Investig 2020 Jun 24. Epub 2020 Jun 24.

Embryopulse Fetal Medicine Center, Paphos, Cyprus.

Polycystic ovary syndrome is a complex and heterogenous disorder involving multiple organ systems and different molecular pathways. It is tightly associated with obesity and especially abdominal obesity. As body weight reduction is the main modifiable risk factor for polycystic ovary syndrome, therapeutic approaches in overweight or obese women with polycystic ovary syndrome have been developed. Read More

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http://dx.doi.org/10.1007/s40261-020-00942-2DOI Listing

PROLAPSE: survey about local prostate cancer relapse salvage treatment with external beam re-irradiation: results of the Italian Association of Radiotherapy and Clinical Oncology (AIRO).

J Cancer Res Clin Oncol 2020 Jun 24. Epub 2020 Jun 24.

Advanced Radiation Oncology Department, Cancer Care Center, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Italy.

Purpose: We herein present the results of the first Italian Association of Radiotherapy and Clinical Oncology (AIRO) survey regarding salvage external beam re-irradiation of local prostate cancer relapse named PROLAPSE.

Methods: A questionnaire with 12 items was administered to the 775 Italian radiation oncologist members of the AIRO.

Results: One hundred of the members completed the survey. Read More

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http://dx.doi.org/10.1007/s00432-020-03297-5DOI Listing

Identification of novel genetic variants associated with short stature in a Baka Pygmies population.

Hum Genet 2020 Jun 24. Epub 2020 Jun 24.

University of Pavia, and Onlus Il Bambino E Il Suo Pediatra, Via XX Settembre 28, Galliate, 28066, Novara, Italy.

Human growth is a complex trait determined by genetic factors in combination with external stimuli, including environment, nutrition and hormonal status. In the past, several genome-wide association studies (GWAS) have collectively identified hundreds of genetic variants having a putative effect on determining adult height in different worldwide populations. Theoretically, a valuable approach to better understand the mechanisms of complex traits as adult height is to study a population exhibiting extreme stature phenotypes, such as African Baka Pygmies. Read More

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http://dx.doi.org/10.1007/s00439-020-02191-xDOI Listing

Effective treatment of relapsed prostate small cell carcinoma with amrubicin: report of a case.

Int Cancer Conf J 2020 Jul 13;9(3):155-158. Epub 2020 May 13.

Department of Urology, Japan Organization of Occupational Health and Safety, Chugoku Rosai Hospital, 1-5-1 Hirotagaya, Kure, 737-0193 Japan.

Standard therapy for metastatic small cell carcinoma of the prostate (SCCP) remains undefined. We have effectively treated relapsed SCCP with amrubicin. A 72-year-old patient, diagnosed with T4N1M0 prostate cancer, started hormonal therapy in May 2012, elsewhere, and his prostate-specific antigen levels remained low. Read More

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http://dx.doi.org/10.1007/s13691-020-00416-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297924PMC

Calcium-sensing receptor autoantibody-mediated hypoparathyroidism associated with immune checkpoint inhibitor therapy: diagnosis and long-term follow-up.

J Immunother Cancer 2020 Jun;8(1)

Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Background: Immune checkpoint inhibitors (ICIs) have produced significant survival benefit across many tumor types. However, immune-related adverse events are common including autoimmune responses against different endocrine organs. Here, a case of ICI-mediated hypoparathyroidism focusing on long-term follow-up and insights into its etiology is presented. Read More

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http://dx.doi.org/10.1136/jitc-2020-000687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319718PMC

Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study.

Neurology 2020 Jun 24. Epub 2020 Jun 24.

From the Departments of Neurology (A.R., E.S., I.D., H.H., S.J., H.J., A.L., H.S., S.P., R.S.I., L.M.) and Radiology (J.D., M.J.d.L., L.M.), Weill Cornell Medical College; Division of Biostatistics and Epidemiology (K.H., I.D.), Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, NY; ADM Diagnostics (R.A., D.M.), Chicago, IL; and Departments of Pharmacology and Neurology (R.D.B.), College of Medicine, University of Arizona, Tucson.

Objective: To investigate sex differences in late-onset Alzheimer disease (AD) risks by means of multimodality brain biomarkers (β-amyloid load via C-Pittsburgh compound B [PiB] PET, neurodegeneration via F-fluorodeoxyglucose [FDG] PET and structural MRI).

Methods: We examined 121 cognitively normal participants (85 women and 36 men) 40 to 65 years of age with clinical, laboratory, neuropsychological, lifestyle, MRI, FDG- and PiB-PET examinations. Several clinical (e. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009781DOI Listing

HEREDITARY ENDOCRINE TUMOURS: CURRENT STATE-OF-THE-ART AND RESEARCH OPPORTUNITIES: The state of science in medullary thyroid carcinoma: current challenges and unmet needs.

Endocr Relat Cancer 2020 Aug;27(8):T27-T39

Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer, Houston, TX, USA.

The 16th International Multiple Endocrine Neoplasia Workshop (MEN2019) held in Houston, TX, USA, focused on emerging topics in the pathogenesis and therapy of malignant endocrine tumors associated with MEN syndromes. With MEN-2 syndromes, the most common malignancy is medullary thyroid carcinoma (MTC). In the spirit of the original MEN meeting workshop model, the conference included didactic lectures and interactive working groups of clinicians and researchers focused on the state of science in MTC and ongoing challenges or unmet needs in the understanding of MTC and to develop strategies to address these issues. Read More

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http://dx.doi.org/10.1530/ERC-20-0110DOI Listing

L-type amino acid transporter 1, LAT1, in growth hormone-producing pituitary tumor cells.

Mol Cell Endocrinol 2020 Jun 21;515:110868. Epub 2020 Jun 21.

Division of Endocrinology and Metabolism, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Pituitary tumors (PTs) can cause significant mortality and morbidity due to limited therapeutic options. L-type amino acid transporters (LATs), in particular, the LAT1 isoform, is expressed in a variety of tumor cells. Pharmacological inhibition or genetic ablation of LAT1 can suppress leucine transport into cancer cells, resulting in suppression of cancer cell growth. Read More

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http://dx.doi.org/10.1016/j.mce.2020.110868DOI Listing

Enzalutamide plus androgen-deprivation therapy in hormone-sensitive prostate cancer: new perspectives from a current Phase III clinical trial.

Future Oncol 2020 Jun 24. Epub 2020 Jun 24.

Department of Urology, Eberhard-Karls-University Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Germany.

Prostate cancer is a major health issue with an incidence of 1,100,000 worldwide. Eventually, 20-40% of curatively treated patients will face a biochemical recurrence. Lately, the treatment options in metastasized hormone sensitive prostate cancer (mHSPC) were rapidly evolving after years of stagnation. Read More

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http://dx.doi.org/10.2217/fon-2019-0509DOI Listing

Effects of IVF therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

Clin Endocrinol (Oxf) 2020 Jun 23. Epub 2020 Jun 23.

Division of Biomedical Sciences (T.M.B.), Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, United Kingdom.

Rationale: In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. Read More

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http://dx.doi.org/10.1111/cen.14270DOI Listing

Uncontrolled Acute Intermittent Porphyria as a Cause of Spontaneous Abortion.

Med Arch 2020 Apr;74(2):153-155

Clinic for Urology, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: The association of acute intermitetn porphyria (AIP) with pregnancy and as a cause of spontaneous abortion is rare.

Aim: To show a case of AIP known before pregnancy in a patient who had a spontaneous abortion.

Case Report: A gynecologist examined 26-year-old patient in the 8th week of gestation, due to initial spontaneous abortion, abdominal pain, constipation, muscle weakness, vomiting and dark colour of urine. Read More

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http://dx.doi.org/10.5455/medarh.2020.74.153-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296395PMC

Immune-checkpoint inhibitors and metastatic prostate cancer therapy: Learning by making mistakes.

Cancer Treat Rev 2020 Jun 10;88:102057. Epub 2020 Jun 10.

Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. Electronic address:

Despite advances in metastatic prostate cancer therapy, expected survival for patients in the castration-resistant phase of disease is poor. Immune-checkpoints inhibitors significantly prolonged life expectancy in some solid tumors and have been evaluated also in advanced stage prostate cancer. The majority of data available derive from preliminary phase I and II trials evaluating CTLA-4 and PD-1 as monotherapy or in combination with each other, vaccines, radiotherapy or targeted/hormonal therapy, achieving only limited benefits in terms of biochemical and radiologic responses. Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102057DOI Listing

The Many Faces of Endometriosis-Related Neoplasms in the Same Patient: A Brief Report.

Gynecol Obstet Invest 2020 Jun 22:1-6. Epub 2020 Jun 22.

Unità di Gineco-Patologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy,

Introduction: Endometriosis is a common benign gynecological condition that can be associated with a slightly increased risk of developing a wide range of malignancies.

Case Presentation: We herein report a singular case of a 62-year-old woman with a history of pelvic endometriosis, referred to our institution for chronic pelvic pain and uterine bleeding, with clinical and radiological evidence of left ovarian mass of 18 cm in largest diameter and multiple nodular mural lesions of the uterine cavity. The patient underwent exploratory laparotomy followed by hysterectomy, bilateral salpingo-oophorectomy, and omentectomy with pelvic lymph-node sampling. Read More

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http://dx.doi.org/10.1159/000508225DOI Listing

Clinical Characteristics of Metastatic Prostate Cancer Patients Infected with COVID-19 in South Italy.

Oncology 2020 Jun 22:1-5. Epub 2020 Jun 22.

Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy.

Background: To date, the clinical characteristics of coronavirus disease 19 (COVID-19)-infected urologic cancer patients are unknown.

Methods: We have analyzed all patients with prostate cancer undergoing hormonal or chemotherapy treatment and receiving telephone and in person pre-triage between March 1 and 27, 2020, at the Tortora Hospital, Pagani, Italy.

Results: Among 72 patients, 48 and 24 were hormone-sensitive (HS) and castration-resistant prostate cancer (CRPC), respectively; 0 HS and 2 (8. Read More

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http://dx.doi.org/10.1159/000509434DOI Listing

Açaí ( Mart) Consumption and Prevention of Chronic Diseases: Is There an Association? A Preliminary Study.

ScientificWorldJournal 2020 1;2020:5782485. Epub 2020 Jun 1.

Pathology Department, Post-Graduate Program in Adult Health, Federal University of Maranha˜o, Sa˜o Luís, Maranha˜o, Brazil.

Background: Flavonoids from a variety of fruits, including açaí, have beneficial antioxidant activity in several diseases, including cancer. Breast cancer is the second most prevalent cancer among Brazilian women. Studies have shown the action of flavonoids on neoplastic cells, as well as on diabetes and neurodegenerative and cardiovascular diseases. Read More

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http://dx.doi.org/10.1155/2020/5782485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285393PMC

Fertility preservation in women with early-stage gynecologic cancer: optimizing oncologic and reproductive outcomes.

Int J Gynecol Cancer 2020 Jun 21. Epub 2020 Jun 21.

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Baylor College of Medicine, Houston, TX, United States

Almost all standard therapies for gynecologic cancer, including surgical intervention, gonadotoxic chemotherapy, and radiation therapy, threaten a woman's childbearing potential. Preservation of fertility should be discussed with premenopausal women with early-stage gynecologic cancer shortly after diagnosis and, for women who desire to preserve fertility, during treatment planning. Many authors have investigated both oncologic and reproductive outcomes following fertility-sparing therapy, and there is ongoing development of assisted reproduction techniques available to cancer patients and survivors. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001328DOI Listing