116,555 results match your criteria Hormonal Therapy


Gene polymorphisms of angiotensin-converting enzyme and angiotensinogen and risk of idiopathic ischemic stroke.

Gene 2018 Dec 3. Epub 2018 Dec 3.

Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, H.G.R. No 1. Dr. "Carlos Mac Gregor Sánchez Navarro" Instituto Mexicano del Seguro Social, Gabriel Mancera No. 222, Colonia Del Valle, CP 03100 Ciudad de México, Mexico.

Objective: The renin-angiotensin system (RAS) is a hormonal signaling mechanism implicated in the atherosclerosis and regulation of blood pressure. Angiotensin-converting enzyme (ACE) a key enzyme in the RAS, plays important roles in vascular remodeling atherosclerosis, and ischemic stroke. The aim of this study was to examine the possible contribution of the I/D in the ACE gene, M235T and T174M in the angiotensinogen (AGT) gene polymorphisms with ischemic stroke in young Mexican population. Read More

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December 2018
1 Read

NEW INSIGHTS ON THE REGULATION OF CANCER CACHEXIA BY N-3 POLYUNSATURATED FATTY ACIDS.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Institute of Physical Activity Sciences and Sports, Cruzeiro do Sul University, Sao Paulo, Brazil,; Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil;. Electronic address:

Cancer cachexia is a multifactorial syndrome that develops during malignant tumor growth. Changes in plasma levels of several hormones and inflammatory factors result in an intense catabolic state, decreased activity of anabolic pathways, anorexia, and marked weight loss, leading to cachexia development and/or accentuation. Inflammatory mediators appear to be related to the control of a highly regulated process of muscle protein degradation that accelerates the process of cachexia. Read More

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December 2018
2 Reads

GLUT3 expression in cystic change induced by hypoxia in pituitary adenomas.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

S Wang, Neurosurgery, Fuzhou General Hospital, Fuzhou, China., Fuzhou, China.

Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high energy metabolisms. Read More

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December 2018
1 Read

Cardiovascular effects and molecular mechanisms of bisphenol A and its metabolite MBP in zebrafish.

Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.

The plastic monomer bisphenol A (BPA) is one of the highest production volume chemicals in the world and is frequently detected in wildlife and humans, particularly children. BPA has been associated with numerous adverse health outcomes relating to its estrogenic and other hormonal properties, but direct causal links are unclear in humans and animal models. Here we simulated measured (1×) and predicted worst-case (10×) maximum foetal exposures for BPA, or equivalent concentrations of its metabolite MBP, using fluorescent reporter embryo-larval zebrafish capable of quantifying Estrogen Response Element (ERE) activation throughout the body. Read More

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December 2018

Two ancient neuropeptides, PACAP and AVP, modulate motivated behavior at synapses in the extrahypothalamic brain: a study in contrast.

Cell Tissue Res 2018 Dec 5. Epub 2018 Dec 5.

Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, NIMH-IRP, Building 49, Room 5A-32, 9000 Rockville Pike, Bethesda, MD, USA.

We examine evolutionary aspects of two primordial neuropeptides, arginine vasopressin (AVP) and pituitary adenylate cyclase-activating polypeptide (PACAP); the distribution of AVP and PACAP and their receptors in mammals; AVP and PACAP release patterns relevant to their roles in neuroendocrine control in brain and periphery; and finally the intricate interlocking of homeostatic and allostatic regulation created by extrahypothalamic AVP and PACAP projections to brain circuit nodes important in controlling appetitive, avoidance and aggressive motor responses. A cardinal feature of peptide neurotransmission important in regulatory control of organismic responses and emphasized in this review, is that neuropeptides are released from large dense-core vesicles docked not only within axonal varicosities and dendrites but also at presynaptic nerve terminal sites, along with small clear synaptic vesicles, at active zones. Peptide transmitter nerve terminals, from hypothalamic and other projections, are distributed widely to multiple brain areas important in integrative control of behavior. Read More

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December 2018

Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels.

Immunol Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, 32 Turan Avenue, Astana, 010000, Kazakhstan.

The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10-17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). Read More

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December 2018
1 Read

New Achievements in High-Pressure Processing to Preserve Human Milk Bioactivity.

Front Pediatr 2018 16;6:323. Epub 2018 Nov 16.

Neonatal and Intensive Care Department, University Hospital, Medical University of Warsaw, Warsaw, Poland.

High-pressure processing (HPP) is a non-thermal technology that is being increasingly applied in food industries worldwide. It was proposed that this method could be used as an alternative to holder pasteurization (HoP; 62.5°C, 30 min) in milk banks but its impact on the immunologic, enzymatic and hormonal components of human milk has not yet been evaluated in detail. Read More

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November 2018
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Venous thrombosis and hormonal contraception: what's new with estradiol-based hormonal contraceptives?

Open Access J Contracept 2018 8;9:75-79. Epub 2018 Nov 8.

Institute of Obstetrics and Gynecology, Department of Medical Area, University of Udine, Udine, Italy.

Objective: Estradiol (E2)-based hormonal contraceptives impact less than ethinylstradiol (EE) contraceptives on venous thromboembolism (VTE) in comparison to formulations with EE.

Study Design: In this article, the pharamacologic data of EE and E2 were briefly reviewed, along with the induced biologic effect. These data were then related to a recent large international prospective, controlled, non-interventional cohort active surveillance study, on the cardiovascular risk of users of different types of combined estroprogestin contraceptive (CEPC). Read More

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November 2018

Serotonin receptors of 5-HT2 type in the hypothalamic arcuate nuclei (ARC) positively regulate liver cytochrome P450 via stimulation of the growth hormone-releasing hormone - growth hormone (GHRH-GH) hormonal pathway.

Drug Metab Dispos 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pharmacology, Polish Academy of Sciences

Our recent study carried out after local injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine into the arcuate nuclei (ARC) of the hypothalamus suggested a positive influence of the serotonergic innervation of the ARC on growth hormone secretion and growth hormone-dependent expression of cytochrome P450. The aim of our present study was to determine the effect of the activation of the 5-HT1 or 5-HT2 type receptors in the ARC on the expression and activity of cytochrome P450 in the liver of male rats. The serotonergic agonists 5-CT (5-carboxyamidotryptamine, a 5-HT1 type receptor agonist) or DOI (2,5-dimethoxy-4-iodoamphetamine, a 5-HT2 type receptor agonist) were injected into the ARC for 5 days. Read More

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December 2018
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The Interleukin-17 Family of Cytokines in Breast Cancer.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Institut Jean Godinot, Unicancer, F-51726 Reims, France.

Breast cancer (BC) is the most common cancer in women worldwide and remains a major cause of mortality with an expected 137,000 death this year in Europe. Standard management of metastatic BC comprises hormonotherapy, chemotherapy, and targeted therapies. Cyclin dependent kinase (CDK) and mammalian target of rapamycin (mTOR) inhibitors have recently proved their efficiency in hormonal receptor expressing BC. Read More

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December 2018

Aromatase inhibitor therapy for endometrial stromal sarcoma - two-centre experience.

Ginekol Pol 2018 ;89(11):607-610

Department of Oncology and Radiotherapy, Medical University of Gdansk, Poland.

Objectives: Endocrine therapy is the recommended systemic treatment for steroid receptor positive endometrial stromal sarcoma (ESS). There is no current consensus on the optimal hormonal therapy for ESS. The literature offers several reports on advanced/recurrent/metastatic ESS patients treated with progestins, whereas data on the efficacy of aromatase inhibitors are scarce. Read More

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January 2018

The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review.

Hum Reprod Update 2018 Dec 1. Epub 2018 Dec 1.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial.

Objective And Rationale: We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk among postmenopausal women.

Search Methods: The electronic databases Medline Ovid, Web of Science and Cochrane Central were systematically searched to identify studies published before 30 January 2018. Read More

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December 2018
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Spawning performance, serum sex steroids, and ovarian histology in wild-caught Levantine scraper, Capoeta damascina (Valenciennes, 1842) treated with various doses of sGnRHa + domperidone.

J Anim Sci 2018 Dec;96(12):5253-5264

School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL.

As global aquaculture continues to expand, increasing efforts are focusing on assisted reproductive technologies. This study sought to test whether salmon GnRH [D-Arg6, Pro9NEt]) analogue (sGnRHa) + domperidone injection at 0.25 mL/body weight (BW; 5-μg sGnRHa + 2. Read More

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December 2018

Maternal use of hormonal contraception and risk of childhood leukaemia - Authors' reply.

Lancet Oncol 2018 Dec;19(12):e659

Virus, Lifestyle and Genes, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark; Department of Gynaecology, Rigshospitalet, Copenhagen, Denmark.

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December 2018

Maternal use of hormonal contraception and risk of childhood leukaemia.

Lancet Oncol 2018 Dec;19(12):e658

Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, NY 10032, USA; Division of Epidemiology and Biostatistics, Department of Obstetrics, Gynecology, and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

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December 2018

Maternal use of hormonal contraception and risk of childhood leukaemia.

Lancet Oncol 2018 Dec;19(12):e657

Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China. Electronic address:

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December 2018

Insulin and incretin responses to grazing in insulin-dysregulated and healthy ponies.

J Vet Intern Med 2018 Dec 2. Epub 2018 Dec 2.

Department of Bioscience, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: Supraphysiological insulin and incretin responses to a cereal-based diet have been described in horses and ponies with insulin dysregulation (ID). However, the hormonal responses to grazing have not yet been described.

Objectives: To determine if there is a difference in the insulin and incretin responses to grazing pasture between insulin-dysregulated and healthy ponies. Read More

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December 2018

Clinical aspects of circulating miRNA-335 in breast cancer patients: A prospective study.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

High Throughput Molecular and Genetic Laboratory, Center for Excellences for Advanced Sciences, Giza, Egypt.

Background: The impact of aberrant expression of miRNAs, small noncoding RNAs of 19 to 23 nucleotide, has been reported in different types of cancer, such as breast cancer. Authors aim to investigate the role of circulating miRNA-335 as a diagnostic and prognostic marker for breast cancer.

Materials And Methods: miRNA-335 expression was measured in primary breast cancer patients (n = 106), patients with benign breast lesion (n = 49) and healthy individuals as control (n = 40) using quantitative real-time polymerase chain reaction and its diagnostic efficacy, relation with clinicopathological factors, and disease-free survival (DFS) and overall survival (OS) were assessed. Read More

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December 2018

Selection and Validation of Novel RT-qPCR Reference Genes under Hormonal Stimuli and in Different Tissues of Santalum album.

Sci Rep 2018 Nov 30;8(1):17511. Epub 2018 Nov 30.

Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, the Chinese Academy of Sciences, Guangzhou, 510650, China.

Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) is a widely used technique to investigate gene expression levels due to its high throughput, specificity, and sensitivity. An appropriate reference gene is essential for RT-qPCR analysis to obtain accurate and reliable results. To date, no reliable reference gene has been validated for the economically tropical tree, sandalwood (Santalum album L. Read More

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November 2018
5.078 Impact Factor

Thrombin generation during a regular menstrual cycle in women with von Willebrand disease.

Sci Rep 2018 Nov 30;8(1):17467. Epub 2018 Nov 30.

Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Fluctuations of the sex steroids during the menstrual cycle might significantly influence hemostasis. This association, derived from a number of the observations on healthy women, is yet to be described in females affected by bleeding disorders. The aim of the current study was to assess the changes in hemostatic variables in women with vWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with healthy controls. Read More

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November 2018

Evaluation and management of heavy menstrual bleeding in adolescents: the role of the hematologist.

Authors:
Sarah H O'Brien

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):390-398

Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, The Ohio State University, Columbus, OH; and.

Heavy menstrual bleeding (HMB) is frequently reported by adolescents. The role of the hematologist is threefold in evaluating such patients: (1) perform a clinical and laboratory evaluation for an underlying bleeding disorder on the basis of the degree of clinical suspicion, (2) identify and manage any concomitant iron deficiency, and (3) provide input to the referring provider regarding the management of HMB, particularly for patients with identified hemostatic defects. Several clues in the menstrual history should raise suspicion for an underlying bleeding disorder, such as menses lasting >7 days, menstrual flow which soaks >5 sanitary products per day or requires product change during the night, passage of large blood clots, or failure to respond to conventional therapies. Read More

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November 2018

[Short-term safety profile of cross-hormonal therapy in trans-male subjects].

Medicina (B Aires) 2018 ;78(6):399-402

Laboratorio de Endocrinología Hospital Carlos G. Durand, Buenos Aires, Argentina.

A trans-male (TM) is a biologically female person with male gender identity who wishes to acquire male sexual characteristics and fulfil a male social role. To achieve that purpose, both cross-hormonal therapy (CHT) and surgical phalloplasty can be used. We evaluated the short term (12 months) safety profile of CHT using different forms of testosterone available for prescription in Argentina. Read More

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January 2018

Sex, Microbes, and Polycystic Ovary Syndrome.

Trends Endocrinol Metab 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, CA, 92093, USA; http://repro.ucsd.edu/thackray. Electronic address:

Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the gut microbiome may play a role in pathological situations of hormonal excess, such as PCOS. Indeed, studies demonstrated that PCOS is associated with decreased alpha diversity and changes in specific Bacteroidetes and Firmicutes, previously associated with metabolic dysregulation. Read More

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November 2018

Hormone variability and hot flash experience: Results from the midlife women's health study.

Maturitas 2019 Jan 23;119:1-7. Epub 2018 Oct 23.

Department of Pathobiology, University of Illinois College of Veterinary Medicine, 2001 S. Lincoln Ave, Urbana, IL, USA. Electronic address:

Objective: Hot flashes are believed to be related to hormonal changes. However, the relationship between hormonal fluctuations and hot flashes has not been studied. The objective of this study is to determine hormone measurement summaries that best explain the incidence of hot flashes in midlife women. Read More

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January 2019

Implications of amino acid sensing and dietary protein to the aging process.

Exp Gerontol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Biochemistry, Carleton University, Ottawa, Canada.

Every organism must adapt and respond appropriately to the source of nutrients available in its environment. Different mechanisms and pathways are involved in detecting the intracellular and extracellular levels of macronutrients including amino acids. Detection of amino acids in food sources is provided by taste cells expressing T1R1 and T1R3 type receptors. Read More

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November 2018

Towards a neurobiology of female aggression.

Neuropharmacology 2018 Nov 28. Epub 2018 Nov 28.

Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA.

Although many people think of aggression as a negative or undesirable emotion, it is a normal part of many species' repertoire of social behaviors. Purposeful and controlled aggression can be adaptive in that it warns other individuals of perceived breaches in social contracts with the goal of dispersing conflict before it escalates into violence. Aggression becomes maladaptive, however, when it escalates inappropriately or impulsively into violence. Read More

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November 2018

Treating Infantile Spasms with High-Dose Oral Corticosteroids: A Retrospective Review of 87 Children.

Pediatr Neurol 2018 Oct 3;87:30-35. Epub 2018 Aug 3.

Departments of Neurology and Pediatrics, The Johns Hopkins Hospital, Baltimore, Baltimore, Maryland. Electronic address:

Background: Hormonal therapy is the treatment of choice in most patients with infantile spasms, but the optimal way to provide this therapy is unclear. Intramuscular adrenocorticotropic hormone (ACTH) has historically used first-line; however, there are significant logistical and financial issues. Our institution has used high-dose prednisolone as the first-line hormonal treatment of infantile spasms since 2006 and published our early experience with 15 infants in 2009. Read More

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October 2018

Head-Out Aquatic Exercise for Generally Healthy Postmenopausal Women: A Systematic Review.

J Phys Act Health 2018 Dec 2:1-22. Epub 2018 Dec 2.

Background: Aquatic exercise (AE) is a method for exercise and rehabilitation to enhance function for various clients.

Objectives: Investigate the effects of head-out AE interventions on the physiological and psychological outcomes of healthy postmenopausal women of age 50-70 years.

Search Strategies: Databases searched included Scopus, ScienceDirect, ResearchGate, PubMed/MEDLINE, PEDro, CINAHL, The Cochrane Library, Nursing & Allied Health Collection: Comprehensive, JSTOR, and OTSeeker. Read More

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December 2018

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

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December 2018

High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men.

Hum Reprod 2018 Dec 4. Epub 2018 Dec 4.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Study Question: Does the presence of human papillomavirus (HPV) in semen impact seminal parameters and sperm DNA quality in white European men seeking medical help for primary couple's infertility?

Summary Answer: HPV seminal infections involving high-risk (HR) genotypes are associated with impaired sperm progressive motility and sperm DNA fragmentation (SDF) values.

What Is Known Already: HPV is commonly present in semen samples. However, whether the presence of HPV in semen is actually associated with impaired sperm parameters and SDF values have yet to be elucidated. Read More

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December 2018
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Incidental Finding of Intrathyroid Metastases of Prostatic Cancer on 18F-Choline PET/CT.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

Oncology Department, Institut Universitaire de Cancérologie-Oncopole, Institut Claudius Regaud, Toulouse, France.

An 85-year-old man with a 2-year history of prostate cancer, treated with radiotherapy and hormonal therapy, presented increased prostatic-specific antigen levels. F-choline PET/CT showed focal prostatic uptake consistent with known local recurrence, increased uptake of 2 hypodense thyroid nodules and of 2 left cervical lymph nodes, suspected as thyroid cancer. Neck ultrasound confirmed the high risk of malignancy, and a guided biopsy (of a thyroid nodule and cervical lymph node) revealed cellular infiltrates thyroid transcription factor-1 (TTF-1) negative and prostatic-specific antigen positive, confirming intrathyroid and cervical lymph node metastases of prostate cancer. Read More

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December 2018
5 Reads

Pleural Mesothelioma Detects by 18F-Choline PET/CT in a Patient With Biochemical Recurrence of Prostate Cancer.

Clin Nucl Med 2018 Dec 3. Epub 2018 Dec 3.

Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.

A 73-year-old man with a prostate cancer treated by radical prostatectomy in 2006. For a biochemical recurrence of disease (prostate-specific antigen level, 0.1 ng/mL) during hormonal therapy, patient underwent F-choline PET/CT that showed a significant uptake in a diffuse right pleural thickening. Read More

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December 2018

Acute anterior myocardial infarction in the 36th week of pregnancy: A successful stepwise treatment approach.

Turk Kardiyol Dern Ars 2018 Dec;46(8):702-705

Department of Cardiology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey.

Acute myocardial infarction (AMI) is associated with a high incidence of maternal and fetal complications when it develops during pregnancy or the early postpartum period. The pathophysiology involves various factors, including alterations in the vascular wall and hypercoagulability as a result of the hormonal and hemodynamic effects of pregnancy. It frequently occurs due to the development of a thrombus following a ruptured plaque. Read More

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December 2018

The duration of infertility affects semen parameters in primary infertile men: results of a single-centre, cross-sectional study.

BJU Int 2018 Dec 4. Epub 2018 Dec 4.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Objective: To assess the relationship between the duration of infertility (DI) and the seminal parameters of a cohort of White-European primary infertile men.

Patients And Methods: Data from 1644 infertile men were analysed. Patients were grouped according to the self-reported DI into 12-month time frames. Read More

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December 2018

Transsphenoidal surgery for pituitary adenomas: early results from a single center.

Hormones (Athens) 2018 Dec 4. Epub 2018 Dec 4.

Endocrinology, Department of Translational Medicine, Università del Piemonte Orientale, Via Solaroli 17, 28100, Novara, Italy.

Objective: To evaluate early results of transsphenoidal surgery for pituitary adenomas.

Design: Retrospective evaluation of 90 consecutive patients undergoing endoscopic pituitary adenoma surgery (2007-2016) at "Maggiore della Carità" Hospital in Novara, Italy. Age at diagnosis, sex, symptoms at presentation, hormonal and radiological data, complications of surgery, and short-term follow-up information were collected. Read More

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December 2018

Plasticity Through Canalization: The Contrasting Effect of Temperature on Trait Size and Growth in .

Front Cell Dev Biol 2018 20;6:156. Epub 2018 Nov 20.

Department of Biology, Lake Forest College, Lake Forest, IL, United States.

In most ectotherms, a reduction in developmental temperature leads to an increase in body size, a phenomenon known as the temperature size rule (TSR). In , temperature affects body size primarily by affecting critical size, the point in development when larvae initiate the hormonal cascade that stops growth and starts metamorphosis. However, while the thermal plasticity of critical size can explain the effect of temperature on overall body size, it cannot entirely account for the effect of temperature on the size of individual traits, which vary in their thermal sensitivity. Read More

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November 2018
1 Read

A Case of Clitoral Hypertrophy of Unknown Origin.

Case Rep Obstet Gynecol 2018 1;2018:7865832. Epub 2018 Nov 1.

Department of Pediatrics, Hoshi General Hospital, Koriyama-shi, Fukushima, Japan.

Clitoral hypertrophy is caused by disorders of sex development and it is observed from birth in most cases. We encountered a patient in whom normal morphology at birth may have acquired deformity and hypertrophy. The patient was a 10-year-old girl with a chief complaint of pudendal deformity. Read More

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November 2018
3 Reads

Musculoskeletal pain and symptoms in pregnancy: a descriptive study.

Ther Adv Musculoskelet Dis 2018 Dec 19;10(12):229-234. Epub 2018 Nov 19.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Gülhane School of Medicine, Gaziler Physical Therapy and Rehabilitation Research and Training Hospital, Ankara, Turkey.

Background: Pregnancy-induced hormonal and physiologic changes increase the risk of musculoskeletal problems in pregnancy. The purpose of this report is to provide a comprehensive look at the musculoskeletal pain and symptoms experienced during pregnancy.

Methods: A total of 184 women (mean age 30. Read More

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December 2018

mGluR5 Mediates Dihydrotestosterone-Induced Nucleus Accumbens Structural Plasticity, but Not Conditioned Reward.

Front Neurosci 2018 20;12:855. Epub 2018 Nov 20.

Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN, United States.

Gonadal hormones play a vital role in driving motivated behavior. They not only modulate responses to naturally rewarding stimuli, but also influence responses to drugs of abuse. A commonality between gonadal hormones and drugs of abuse is that they both impact the neurocircuitry of reward, including the regulation of structural plasticity in the nucleus accumbens (NAc). Read More

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November 2018

Need for better indicators of contraception after abortion.

Authors:
Chris Smith

BMJ Sex Reprod Health 2018 Dec 4. Epub 2018 Dec 4.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.

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December 2018
1 Read

Direct Regulation of Phytohormone Actions by Photoreceptors.

Authors:
Yiwen Luo Hui Shi

Trends Plant Sci 2018 Dec 1. Epub 2018 Dec 1.

College of Life Sciences, Capital Normal University, Beijing 100048, China. Electronic address:

Plants must adjust their growth and development adaptively in response to light. Four recent studies have now established novel paradigms connecting light and hormone signaling pathways, in which photoreceptors adopt three modes to directly inhibit internal hormonal responses to external stimuli. Read More

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December 2018

Using the Theory of Planned Behavior to determine pharmacy students' intention to participate in hormonal contraception counseling services.

Curr Pharm Teach Learn 2018 Nov 24;10(11):1488-1495. Epub 2018 Aug 24.

Auburn University Harrison School of Pharmacy, Health Outcomes Research and Policy, 020 James E. Foy Hall, Auburn, AL, United States. Electronic address:

Introduction: Recent policies allow some pharmacists to prescribe hormonal birth control, which may improve access to hormonal contraceptives. This study explored associations between student pharmacists' hormonal contraception knowledge, attitudes, subjective norms, perceived behavioral control to counseling intentions, and preferred learning methods.

Methods: A cross-sectional online survey was developed to assess student pharmacists' hormonal contraception knowledge, perceptions, and counseling intentions. Read More

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November 2018

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups.

Tuberculosis (Edinb) 2018 Dec 18;113:10-18. Epub 2018 Aug 18.

DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Mater Research Institute - The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia. Electronic address:

Type 2 diabetes (T2D) is a prevalent risk factor for tuberculosis (TB), but most studies on TB-T2D have focused on TB patients, been limited to one community, and shown a variable impact of T2D on TB risk or treatment outcomes. We conducted a cross-sectional assessment of sociodemographic and metabolic factors in adult TB contacts with T2D (versus no T2D), from the Texas-Mexico border to study Hispanics, and in Cape Town to study South African Coloured ethnicities. The prevalence of T2D was 30. Read More

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December 2018

The Healing-Promoting Properties of Selected Cyclitols-A Review.

Nutrients 2018 Dec 3;10(12). Epub 2018 Dec 3.

Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 87-100 Torun, Poland.

Introduction: -inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits.

Aim: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols. Read More

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December 2018
2 Reads

Interactive Responses of to Drought and Insect Feeding are Herbivore Species-Specific.

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

Molecular Interaction Ecology, Institute of Water and Wetland Research, Radboud University, P.O. Box 9010, 6500 GL Nijmegen, The Netherlands.

In nature, plants are frequently subjected to multiple biotic and abiotic stresses, resulting in a convergence of adaptive responses. We hypothesised that hormonal signalling regulating defences to different herbivores may interact with drought responses, causing distinct resistance phenotypes. To test this, we studied the hormonal and transcriptomic responses of subjected to drought and herbivory by the generalist (beet armyworm; BAW) or the specialist (Colorado potato beetle; CPB). Read More

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December 2018

Effects of Resistance Exercise on Bone Health.

Endocrinol Metab (Seoul) 2018 Dec;33(4):435-444

Department of Internal Medicine, Seoul National University College of Medicine and Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.

The prevalence of chronic diseases including osteoporosis and sarcopenia increases as the population ages. Osteoporosis and sarcopenia are commonly associated with genetics, mechanical factors, and hormonal factors and primarily associated with aging. Many older populations, particularly those with frailty, are likely to have concurrent osteoporosis and sarcopenia, further increasing their risk of disease-related complications. Read More

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December 2018
1 Read

Case Report: Persistent Genital Arousal Disorder in an Adolescent Woman.

Authors:
Kelly A Curran

J Pediatr Adolesc Gynecol 2018 Dec 1. Epub 2018 Dec 1.

Section of Adolescent Medicine, Department of Pediatrics, University of Oklahoma Health Sciences Center, 1200 Children's Avenue, Suite 12204 Oklahoma City, OK. Electronic address:

Background: After several visits with unrelated complaints, a 16-year-old female disclosed symptoms of unwanted genital arousal and was diagnosed with persistent genital arousal disorder (PGAD).

Case: A 16-year-old female with history of depression, sexual abuse, and dysmenorrhea insistently requested etonogestrel rod removal. At two visits following implant removal, the patient disclosed the reason for her insistence: PGAD symptoms developed after implant insertion, though they worsened with removal. Read More

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December 2018
10 Reads