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    Demodicosis Treatment with Systemic Ivermectin.
    Skinmed 2017 1;15(4):293-295. Epub 2017 Aug 1.
    Clínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Clínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Lisboa, Portugal.
    A 23-year-old white man presented to our dermatology department complaining of pruriginous and erythematous papulopustules on the right cheek that had developed 6 months previously. He had a history of chronic blepharitis, complicated by a recurrent hordeolum that had been treated with warm compresses and topical antibiotic ointment (chloramphenicol) for approximately 2 years. The patient had oily skin and atopy (allergic rhinitis) and did not experience photosensitivity or flushing or have previous exposure to immunosuppressants or topical/systemic corticosteroids. Read More

    Incidence of Ophthalmic Disorders in Patients Treated with the Antineoplastic Agent S-1.
    Gan To Kagaku Ryoho 2017 Jun;44(6):501-506
    Division of Drug Information, Dept. of Pharmacotherapeutics, Showa University School of Pharmacy.
    S-1 is an oral antineoplastic agent containing tegafur, gimeracil, and oteracil potassium. Recently, ophthalmic disorders, particularly epiphora, have been reported. We retrospectively investigated the incidence of ophthalmic disorders in patients treated with a regimen containing S-1 at our institution. Read More

    Study on Steroid Induced Ocular Findings in Children with Nephrotic Syndrome.
    J Clin Diagn Res 2017 Mar 1;11(3):SC05-SC06. Epub 2017 Mar 1.
    Senior Resident, Department of Paediatric, JK Lon Hospital, SMS Medical College, Jaipur, Rajasthan, India.
    Introduction: Long term use of corticosteroids in Nephrotic Syndrome (NS) is associated with ocular complications such as Posterior Subcapsular Cataract (PSC), glaucoma, increased intra-ocular pressure, ptosis, mydriasis, eyelid skin atrophy, keratisis, thinning of cornea and sclera, repeated hordeolum exacerbations.

    Aim: To determine ocular abnormalities in children with NS and their association with steroid dosing and duration.

    Materials And Methods: Hundred patients with NS in the age group of 2-18 years, with no evidence of other systemic disease, were considered for the study. Read More

    Acupuncture for acute hordeolum.
    Cochrane Database Syst Rev 2017 02 9;2:CD011075. Epub 2017 Feb 9.
    School of Chinese Medicine, The University of Hong Kong, 10 Sassoon Road, Pokfulam Rd, Hong Kong, Hong Kong, China.
    Background: Hordeolum is an acute, purulent inflammation of the eyelid margin usually caused by obstructed orifices of the sebaceous glands of the eyelid. The condition, which affects sebaceous glands internally or externally, is common. When the meibomian gland in the tarsal plate is affected, internal hordeolum occurs, while when the glands of Zeis or Moll associated with eyelash follicles are affected, external hordeolum, or stye occurs. Read More

    Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review.
    Korean J Parasitol 2016 Dec 31;54(6):787-792. Epub 2016 Dec 31.
    Department of Medical Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    Cutaneous leishmaniasis (CL) is a protozoan disease which is endemic in Iran. It is transmitted by the sand fly. The eyelid is rarely involved possibly because the movement of the lids impedes the sand fly from biting the skin in this region. Read More

    Non-surgical interventions for acute internal hordeolum.
    Cochrane Database Syst Rev 2017 01 9;1:CD007742. Epub 2017 Jan 9.
    Center for Clinical Trials and US Cochrane Center, Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Mail Rm E6152, Baltimore, MD, USA, 21205.
    Background: A hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and resolves without treatment; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. Read More

    Risk Factors and Symptoms of Meibomian Gland Loss in a Healthy Population.
    J Ophthalmol 2016 14;2016:7526120. Epub 2016 Nov 14.
    Department of General Pathology, Pomeranian Medical University, Al. Powstancow Wlkp. 72, 70-111 Szczecin, Poland.
    . The aim of this study was to investigate the relationships between MGL and ocular symptoms, several systemic conditions, and key markers of ocular surface health. . Read More

    [Merkel cell carcinoma of the eyelid. An often unrecognized tumor entity : Clinical aspects and treatment strategies].
    Ophthalmologe 2017 Feb;114(2):134-139
    Zentrum für Augenheilkunde, Universitätsklinik Köln, Kerpener Str. 62, 50924, Köln, Deutschland.
    Merkel cell carcinoma of the eyelid is an aggressive, highly malignant tumor of the skin. Totaling approximately 0.5 % of all tumors of the eyelid, it constitutes a relatively small group of lid tumors. Read More

    Parents' awareness and perception of children's eye diseases in Nigeria.
    J Optom 2017 Apr - Jun;10(2):104-110. Epub 2016 Jul 14.
    Department of Optometry, Faculty of Life Sciences, University of Benin, Nigeria.
    Purpose: Most causes of childhood blindness are treatable or preventable. Knowledge of parents' awareness and perception of eye problems is important in helping to understand parents' eye care seeking behavior. This understanding becomes necessary as early detection and intervention can be effective when done at an early age. Read More

    Evaluation of the Painful Eye.
    Am Fam Physician 2016 Jun;93(12):991-8
    Tripler Army Medical Center, Honolulu, HI, USA.
    Eye problems constitute 2% to 3% of all primary care and emergency department visits. Common eye conditions that can cause eye pain are conjunctivitis, corneal abrasion, and hordeolum, and some of the most serious eye conditions include acute angle-closure glaucoma, orbital cellulitis, and herpetic keratitis. The history should focus on vision changes, foreign body sensation, photophobia, and associated symptoms, such as headache. Read More

    Comparative Clinical Outcomes of Pediatric Patients Presenting With Eyelid Nodules of Idiopathic Facial Aseptic Granuloma, Hordeola, and Chalazia.
    J Pediatr Ophthalmol Strabismus 2016 Jul 17;53(4):206-11. Epub 2016 May 17.
    Purpose: To present the clinical features of the eyelid nodules observed in a newly determined dermatologic disorder, idiopathic facial aseptic granuloma (IFAG), and to compare them with children having acute hordeolum and chalazion.

    Methods: Duration of the lesion, localization, presence of coexisting facial nodules, management strategies, and response time to topical/oral antibiotics were retrospectively reviewed in 50 children with IFAG, acute hordeolum, or chalazion.

    Results: Fourteen children with one or more IFAG nodules on their eyelids, 28 children with one or more acute hordeolum, and 8 children with one or more chalazion were examined. Read More

    Blepharokeratoconjunctivitis in childhood: corneal involvement and visual outcome.
    Eye (Lond) 2016 Mar 4;30(3):438-46. Epub 2015 Dec 4.
    Ophthalmology and Visual Sciences Institute, School of Medicine, Tecnológico de Monterrey, Monterrey, Mexico.
    Purpose: The main objective of this study is to describe the prevalence, degree and risk of corneal involvement, and visual impact in a pediatric population with blepharokeratoconjunctivitis (BKC).

    Methods: Retrospective, observational, case-control study. Clinical records of patients ≤16 years old with BKC seen between 2006 and 2012 were reviewed. Read More

    Acupuncture for acute hordeolum.
    Cochrane Database Syst Rev 2014 Apr;2014
    School of Chinese Medicine, The University of Hong Kong, Hong Kong, China.
    This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this review is to determine the effects and, when possible, the safety of acupuncture for the treatment of acute hordeola, in comparison to no specific treatment (e.g. Read More

    [Exploration on the application characteristics of bloodletting therapy for the diseases relevant with soft tissue infection by data mining technology].
    Zhongguo Zhen Jiu 2013 Sep;33(9):803-7
    School of TCM, Hebei Medical University, Shijiazhuang 050091, China.
    Objective: Using the data mining technology to analyze the application law of bloodletting therapy for the diseases relevant with soft tissue infection and explore the effect specificity of bloodletting therapy.

    Methods: The variety of diseases treated with bloodletting therapy was taken as the sample data by collecting the reports from the periodical literatures. The network database of bloodletting literature was set up. Read More

    [Measurement of the index of infection by Demodex spp in patients with chronic blepharitis and in patients without other ocular diseases].
    Rev Chilena Infectol 2013 Oct;30(5):494-501
    Universidad de Concepción, Concepción, Chile,
    Background: Infestation by Demodex spp. in the palpebral edge follicles in humans is common. However, these mites are not routinely diagnosed in patients with or without ocular pathologies in Chile and their relevance is unclear. Read More

    [Randomized controlled clinical trials for treatment of external sty with ear-apex blood-letting].
    Zhen Ci Yan Jiu 2013 Apr;38(2):148-51
    The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
    Objective: To observe the clinical therapeutic effect of ear-apex blood-letting for external sty.

    Methods: A total 102 sty patients were randomized into ear-apex blood-letting group (n = 51) and routine treatment (medication) group (n = 51) according to computer-aided randomization procedure. Ear-apex-bloodletting (5-6 blood drops/time) was performed once daily for 3 times for the patients of blood-letting group. Read More

    Interventions for acute internal hordeolum.
    Cochrane Database Syst Rev 2013 Apr 30(4):CD007742. Epub 2013 Apr 30.
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
    Background: Hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. Read More

    Ocular inflammation and infection.
    Emerg Med Clin North Am 2013 May;31(2):387-97
    Department of Emergency Medicine, Synergy Medical Education Alliance, 1000 Houghton Avenue, Saginaw, MI 48602, USA.
    Ocular inflammation and infection may involve any part of the eye and surrounding tissue. A complete examination, including visual acuity, extraocular movements, pupillary response, slit lamp examination, and fluorescein staining, is often required to establish the diagnosis. Pain relief may be achieved with oral analgesics and cycloplegics. Read More

    Pharmacokinetic comparison of 2 formulations of anastrozole (1 mg) in healthy Korean male volunteers: a randomized, single-dose, 2-period, 2-sequence, crossover study.
    Clin Ther 2012 Feb 26;34(2):305-13. Epub 2012 Jan 26.
    Department of Clinical Pharmacology and Therapeutics, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
    Background: Anastrozole is an aromatase inhibitor used to treat advanced breast cancer in postmenopausal women. A generic 1-mg tablet of anastrozole was recently developed.

    Objective: The study was designed to provide data to submit to Korean regulatory authorities to allow marketing of the test formulation. Read More

    Current pattern treatment of hordeolum by ophthalmologists in Thailand.
    J Med Assoc Thai 2011 Jun;94(6):721-4
    Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
    Objective: To assess the current pattern of treatment among ophthalmologists in Thailand.

    Material And Method: A two-page Thai questionnaire was distributed to Thai ophthalmologists' annual meeting. Other questionnaires were sent to the eye institute or conducted by telephone interviews. Read More

    [Eye lid reconstruction after bilateral palpebral complete necrosis after an extensive Pseudomonas aeruginosa infection (infected neonatal hordeolum)].
    Oftalmologia 2010 ;54(3):66-71
    Spitalul Clinic de Urgenţă Pentru Copii Cluj-Napoca.
    In this article we will present a clinical case particularly interesting in terms of diagnosis, treatment and evolution of a infant who presented in our service because very serious evolution of a hordeolum, with infection and then complete necrosis of lower and upper eyelids of both eyes. The substrate counterproductive evolution was identified later, by genetic analysis (X-linked Bruton congenital agammaglobulinemia). Read More

    Clinical spectrum of pediatric blepharokeratoconjunctivitis.
    J AAPOS 2010 Dec 19;14(6):527-9. Epub 2010 Nov 19.
    Department of Ophthalmology, Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital, New Delhi, India.
    Purpose: To evaluate the incidence, symptoms, clinical signs, and therapy instituted in children with blepharokeratoconjunctivitis (BKC).

    Methods: In this observational, retrospective case series, we reviewed all medical records of pediatric patients presenting to the ophthalmology clinic at the Kalawati Saran Children's Hospital, New Delhi, India from 2003 to 2006. History, clinical characteristics, and treatment protocol were noted, as well as reason for presentation/referral and subsequent diagnosis. Read More

    Interventions for acute internal hordeolum.
    Cochrane Database Syst Rev 2010 Sep 8(9):CD007742. Epub 2010 Sep 8.
    Center for Clinical Trials, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, W5010, Baltimore, Maryland, USA, 21205.
    Background: Hordeolum is a common, painful, inflammation of the eyelid margin that is usually caused by bacterial infection. The infection affects oil glands of the eyelid and can be internal or external. In many cases, the lesion drains spontaneously and resolves untreated; however, the inflammation can spread to other ocular glands or tissues and recurrences are common. Read More

    Prevalence of bacterial pathogens causing ocular infections in South India.
    Indian J Pathol Microbiol 2010 Apr-Jun;53(2):281-6
    Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu- 627001, India.
    Background/aims: The eye may be infected from external sources or through intra-ocular invasion of micro-organisms carried by the blood stream. This study was undertaken to isolate and identify the specific bacterial pathogens causing ocular infections and to determine their in-vitro antibacterial susceptibilities to commonly used antibacterial agents.

    Materials And Methods: A retrospective analysis of all patients with clinically diagnosed bacterial ocular infections such as blepharitis, conjunctivitis, internal and external hordeolum, suppurative scleritis, canaliculitis, keratitis, dacryocystitis, preseptal cellulitis, endophthalmitis and panophthalmitis presenting between January 2005 and December 2005 was performed. Read More

    Necrotising fasciitis of the eyelid with toxic shock due to Pseudomonas aeruginosa.
    Singapore Med J 2010 Mar;51(3):e51-3
    Department of Ophthalmology, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074.
    Necrotising fasciitis is a rare and rapidly spreading soft tissue infection characterised by widespread necrosis of the superficial fascia and usually occurring in the limbs and the abdominal wall. Periocular necrotising fasciitis is unusual due to the excellent blood supply of the facial region. The usual pathogens are Group A beta-haemolytic Streptococcus and Staphylococcus aureus. Read More

    Pharmacokinetic comparison of controlled-release and immediate-release oral formulations of simvastatin in healthy Korean subjects: a randomized, open-label, parallel-group, single- and multiple-dose study.
    Clin Ther 2010 Jan;32(1):206-16
    Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea.
    Background: A controlled-release (CR) formulation of simvastatin was recently developed in Korea. The formulation is expected to yield a lower C(max) and similar AUC values compared with the immediate-release (IR) formulation.

    Objective: The goal of this study was to compare the pharmacokinetics of the new CR formulation and an IR formulation of simvastatin after single- and multiple-dose administration in healthy Korean subjects. Read More

    [Discussion on the suitable diseases and symptoms of bleeding therapy].
    Zhongguo Zhen Jiu 2009 May;29(5):397-9
    Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
    In order to explore the suitable diseases and symptoms treated by bleeding therapy so as to guide the clinical practice. The retrospective study of periodical literature series is used and all clinical literatures about bleeding therapy were searched in the China Journal Full Text Database in CNKI, the VIP Chinese Scientific Journals Full Text Database (CSJD), Wanfang Database, and the Chinese Bio-medical Literature Database, and the frequen cy of the literature and the total cases treated with bleeding therapy were statistically analyzed, and the principles and methods of clinical epidemiology and evidence-based medicine were used to classify and grade the literatures, and the diseases were classified according to the international statistical classification about diseases and related healthy problems (ICD10) issued by World Health Organization. As a result, 1149 effective literatures including 98,526 cases were searched out, which were involved in 18 major systems and 261 kinds of diseases. Read More

    Pott's puffy tumour mimicking preseptal cellulitis.
    Clin Exp Optom 2008 Jul;91(4):400-2
    VA Boston Medical Center, West Roxbury Campus, West Roxbury, Massachusetts, USA.
    Periorbital swelling can be secondary to local infections (for example, hordeolum) or reflective of an adjacent infection (for example, dental disease). Rarely, periorbital swelling can indicate underlying sinus disease; Pott's puffy tumour is a unique and serious form of this process. This paper presents an unusual way in which a smouldering sinusitis can erode through bone and result in orbital cellulitis or intracranial infection. Read More

    Ocular infection and inflammation.
    Emerg Med Clin North Am 2008 Feb;26(1):57-72, vi
    Emergency Medicine Residency, New York University/Bellevue Hospital Center, 462 First Avenue, New York, NY 10016, USA.
    Managing the inflamed or infected eye in the emergency setting presents a diagnostic and therapeutic challenge to the emergency physician; the causes and prognoses range from benign, self-limited illness to organ-threatening pathology. A careful history, with attention to comorbid illnesses and time course, is paramount, as is knowledge of the complete ophthalmologic examination. Much of the organ morbidity is ameliorated with prompt therapy in the emergency department and by initiating ophthalmologic consultation. Read More

    [Professor OUYANG Qun's clinical experience on application of single point].
    Zhongguo Zhen Jiu 2007 Nov;27(11):857-8
    TCM School, Southern Medical University, Guangzhou 510515, China.
    The clinical experience of Professor OUYANG Qun in using single acupoint includes treatment of Meniere's syndrome with Baihui (GV 20), optic neuritis with "Fengyan" (Extra point), painful heel with Xiaguan (ST 7), lymphoid tuberculosis with Quchi (LI 11), acute sore throat with Kongzui (LU 6), painful diseases with "Luolingwu" (Extra point), chest distress with "Kuanxiong" (Extra point), hordeolum with Feishu (BL 13), headache in menstrual period with Xuehai (SP 10), frozen shoulder with Tiaokou (ST 38), toothache with Waihuaijian (Extra point), occipital pain with Chengshan (BL 57) and vomiting with Yongquan (KI 1). Read More

    Periorbital necrotising fasciitis: delay in diagnosis results in loss of lower eyelid.
    Int Ophthalmol 2008 Feb 26;28(1):67-9. Epub 2007 Jun 26.
    The Eye Care Centre, Leighton Hospital, Crewe CW1 4QJ, UK.
    Necrotising fasciitis (NF) is an extremely rare skin and soft tissue infection with extensive necrosis of the subcutaneous tissue and underlying fascia, which usually affects the limbs and trunk. It rarely affects the head and neck region because of the excellent blood supply in this region. We report a case of NF initially misdiagnosed as a traumatic pre-septal cellulitis following self-puncture of a hordeolum externum (stye) and its resistance to aggressive antibiotic therapy resulting in the loss of the lower eyelid. Read More

    Preseptal cellulitis due to Mycobacterium marinum.
    J Laryngol Otol 2007 Jun 14;121(6):606-8. Epub 2006 Dec 14.
    ENT Department, Leighton Hospital, Crewe, UK.
    Mycobacterium marinum is an atypical mycobacterium found in both salt and fresh water. It occasionally causes soft tissue infections after minor trauma, principally affecting the limbs. A 17-year-old male aquarium worker presented with preseptal cellulitis of his right eye, after attempting to lance a hordeolum some days previously. Read More

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