3,449 results match your criteria Hookworms


Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.

Pharmaceuticals (Basel) 2022 May 27;15(6). Epub 2022 May 27.

Laboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed on host blood, resulting in a loss of iron and protein, which can lead to severe anaemia and impaired cognitive development in children. Currently, only one drug, albendazole is efficient to treat hookworm infection and the scientific community fears the rise of resistant strains. Read More

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Human hookworms from Argentina: Differential diagnosis of Necator americanus and Ancylostoma duodenale in endemic populations from Buenos Aires and Misiones.

Rev Argent Microbiol 2022 Jun 17. Epub 2022 Jun 17.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE-CONICET-UNLP), La Plata, Buenos Aires, Argentina.

Hookworm infection is endemic in many countries throughout the world; however, the information about the prevalence of each species, Necatoramericanus and Ancylostomaduodenale, is inaccurate in many South American countries. We aimed to determine the prevalence of human hookworm species by combining the results of both microscopy and PCR among endemic populations in Argentina, represented by natives and immigrants. A total of 140 serial fecal specimens were obtained from natives in the province of Misiones and an immigrant community living in the province of Buenos Aires. Read More

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Affordable artificial intelligence-based digital pathology for neglected tropical diseases: A proof-of-concept for the detection of soil-transmitted helminths and Schistosoma mansoni eggs in Kato-Katz stool thick smears.

PLoS Negl Trop Dis 2022 Jun 17;16(6):e0010500. Epub 2022 Jun 17.

Janssen Global Public Health, Janssen R&D, Beerse, Belgium.

Background: With the World Health Organization's (WHO) publication of the 2021-2030 neglected tropical diseases (NTDs) roadmap, the current gap in global diagnostics became painfully apparent. Improving existing diagnostic standards with state-of-the-art technology and artificial intelligence has the potential to close this gap.

Methodology/principal Findings: We prototyped an artificial intelligence-based digital pathology (AI-DP) device to explore automated scanning and detection of helminth eggs in stool-based specimens prepared with the Kato-Katz (KK) technique, the current diagnostic standard for diagnosing soil-transmitted helminths (STHs; Ascaris lumbricoides, Trichuris trichiura and hookworms) and Schistosoma mansoni (SCH) infections. Read More

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Machine learning-based risk factor analysis and prevalence prediction of intestinal parasitic infections using epidemiological survey data.

PLoS Negl Trop Dis 2022 Jun 14;16(6):e0010517. Epub 2022 Jun 14.

Colgate University, Department of Biology, Hamilton, New York, United States of America.

Background: Previous epidemiological studies have examined the prevalence and risk factors for a variety of parasitic illnesses, including protozoan and soil-transmitted helminth (STH, e.g., hookworms and roundworms) infections. Read More

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National surveillance of hookworm disease in China: A population study.

PLoS Negl Trop Dis 2022 06 9;16(6):e0010405. Epub 2022 Jun 9.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.

Background: Hookworm disease is endemic in China and is widespread globally. The disease burden to humans is great.

Methods: The study described the national surveillance of hookworm implemented in 31 provinces/autonomous regions/municipalities (P/A/Ms) of China in 2019. Read More

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Helminth infections in dogs in Phu Tho Province, northern Vietnam.

Curr Res Parasitol Vector Borne Dis 2022 14;2:100091. Epub 2022 May 14.

Institute of Tropical Medicine, Department of Biomedical Sciences, Nationalestraat 155, 2000 Antwerpen, Belgium.

Helminths are among the most-commonly encountered disease-causing agents in dogs all over the world, including Vietnam. A cross-sectional survey was carried out between March and December 2019 in four dog slaughter-slabs in Yen Lap District, Phu Tho Province, northern Vietnam, aiming to reveal the occurrence of gastrointestinal helminths in dogs. Worms were collected from 350 dog samples and identified by morphological techniques followed by molecular methods for tapeworms and hookworms. Read More

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Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling.

Parasit Vectors 2022 Jun 8;15(1):197. Epub 2022 Jun 8.

Instituto de Investigaciones de Enfermedades Tropicales (IIET), Sede Regional Orán Universidad Nacional de Salta, Salta, Argentina.

Background: The WHO has established a control strategy for Strongyloides stercoralis in school-aged children as well as targets and to maintain control programs for Ascaris lumbricoides, Trichuris trichiura and hookworms. For an efficient development of control programs, it is necessary to know the target countries around the world, as well as the areas within each country where efforts should be focused. Therefore, maps that provide information on the areas at risk for soil-transmitted helminth (STH) infections on a national and sub-national scale would allow for a better allocation of resources. Read More

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Soil-Transmitted Helminths and Anaemia: A Neglected Association Outside the Tropics.

Microorganisms 2022 May 13;10(5). Epub 2022 May 13.

Department of Infectious-Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, 37024 Verona, Italy.

Anaemia is an important cause of morbidity and mortality globally. Among infectious agents responsible for anaemia, helminthic infections are often neglected, particularly in non-endemic countries. However, they should not be neglected in this setting, as international travel and migration are on the rise. Read More

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Administration of Hookworm Excretory/Secretory Proteins Improves Glucose Tolerance in a Mouse Model of Type 2 Diabetes.

Biomolecules 2022 Apr 26;12(5). Epub 2022 Apr 26.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia.

Diabetes is recognised as the world's fastest growing chronic condition globally. Helminth infections have been shown to be associated with a lower prevalence of type 2 diabetes (T2D), in part due to their ability to induce a type 2 immune response. Therefore, to understand the molecular mechanisms that underlie the development of T2D-induced insulin resistance, we treated mice fed on normal or diabetes-promoting diets with excretory/secretory products (ES) from the gastrointestinal helminth . Read More

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Moving beyond the state of the art of understanding resistance mechanisms in hookworms: confirming old and suggesting new associated SNPs.

Acta Trop 2022 May 20;233:106533. Epub 2022 May 20.

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Hookworms represent a serious problem for human and animal health in different parts of the world. One of the suggested control strategies for parasitosis caused by members of the Ancylostomatidae family is mass drug aministration with benzimidazole compounds. This strategy has been proven to lead to the establishment of resistant strains in several nematodes related to SNPs at codons 167, 198 and 200 of the beta-tubulin isotype-1 gene. Read More

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A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.

Sci Adv 2022 05 11;8(19):eabj6894. Epub 2022 May 11.

Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm , with an envelope protein genetically related to G-G glycoproteins from the family Phenuiviridae. Read More

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Global distribution of human hookworm species and differences in their morbidity effects: a systematic review.

Lancet Microbe 2022 Jan 28;3(1):e72-e79. Epub 2021 Sep 28.

Curtin University Faculty of Health Sciences, Perth, WA, Australia; Telethon Kids Institute, Perth, WA, Australia.

The global distribution and morbidity effects for each specific hookworm species is unknown, which prevents implementation of the optimum intervention for local hookworm control. We did two systematic reviews of studies on the proportion of hookworm isolates of each species and genus by region of the world and associations between hookworm species-specific infections and morbidity outcomes, particularly severe anaemia. Necator americanus and Ancylostoma spp were present in all regions of the world, although at different ratios. Read More

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January 2022

A conventional multiplex PCR for the detection of four common soil-transmitted nematodes in human feces: development and validation.

Trop Biomed 2022 Mar;39(1):135-143

Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.

Soil-transmitted helminth (STH) infections, mainly caused by Ascaris lumbricoides, Trichuris trichiura, and hookworms, are among the most common intestinal parasites that infect humans. The infections are widely distributed throughout tropical and subtropical countries, including Malaysia, particularly in underprivileged communities. Microscopic and culture techniques have been used as a gold standard for diagnostic techniques. Read More

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Eprinomectin 5% w/v extended-release injection for the treatment of larval and/or adult Bunostomum phlebotomum, Haemonchus contortus, H. placei, Nematodirus helvetianus, Oesophagostomum radiatum, and Trichostrongylus colubriformis infections in cattle.

Parasitol Res 2022 Jul 3;121(7):2173-2178. Epub 2022 May 3.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany.

In an effort to generate data for regulatory purposes on the therapeutic efficacy of eprinomectin 5% w/v extended-release injection (Eprinomectin ERI) (LongRange®, Boehringer Ingelheim) against infections of immature and adult stages of some nematode species (or stages) which are generally less common or predominantly seen in younger cattle, nine studies (minimum two per parasite and stage) were conducted in the USA and Germany. A total of 218 young cattle were included in seven experimentally induced infection studies (180 animals) and two studies with naturally acquired nematode infections (38 animals), which were compliant with WAAVP and VICH guidelines. In each study, cattle were randomly assigned into groups which received 1 mL per 50 kg body weight of either saline (controls) or Eprinomectin ERI (equivalent to 1 mg eprinomectin per kg body weight) via subcutaneous injection when the parasites were developing fourth-stage larval (L4) or adult nematodes. Read More

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Prevalence and risk factors associated with gastrointestinal parasites of pet dogs in North-Central Algeria.

Comp Immunol Microbiol Infect Dis 2022 Jul 20;86:101817. Epub 2022 Apr 20.

Laboratory of Parasitic Eco-epidemiology and Population Genetics, Pasteur Institute of Algeria, Dely-Brahim, Algiers, Algeria.

The prevalence and risk factors associated with gastrointestinal parasites in dogs were conducted in Blida, North-Central Algeria. The study was carried out over 131 clinically healthy dogs, from March to June 2019, by coprological methods. Of the 131 collected dogs, 61. Read More

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Cross-Sectional Assessment of the Association of Eosinophilia with Intestinal Parasitic Infection in U.S.-Bound Refugees in Thailand: Prevalent, Age Dependent, but of Limited Clinical Utility.

Am J Trop Med Hyg 2022 Mar 7. Epub 2022 Mar 7.

Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia.

The most common causes of eosinophilia globally are helminth parasites. Refugees from high endemic areas are at increased risk of infection compared with the general U.S. Read More

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Prevalence and effect of Plasmodium spp. and hookworm co-infection on malaria parasite density and haemoglobin level: a meta-analysis.

Sci Rep 2022 04 27;12(1):6864. Epub 2022 Apr 27.

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

The dual effects of co-infection of Plasmodium spp. and hookworm on malaria remain under debate. This study investigated prevalence, prevalence odds ratio (POR) of co-infection and impact of co-infection on malaria parasite density and haemoglobin levels in comparison to Plasmodium mono-infection. Read More

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Ancylostoma in dogs in the Caribbean: a review and study from St. Kitts, West Indies.

Parasit Vectors 2022 Apr 21;15(1):139. Epub 2022 Apr 21.

Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.

Background: Little is known about the prevalence of Ancylostoma in dogs in the Caribbean. In view of the number of owned free-roaming and feral dogs within the islands and the ideal subtropical climate for parasite development and environmental survival, Ancylostoma could pose a threat to the health of the dogs as well as a zoonotic risk to people.

Methods: To determine whether generalities about Ancylostoma in dogs in the Caribbean could be made and to obtain a better understanding of the prevalence, published (Scielo, Scopus, and PubMed databases) and gray (e. Read More

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Cross-Sectional Study on Assessment of Frequency of Intestinal Helminth Infections and Its Related Risk Factors among School Children from Adola Town, Ethiopia.

Biomed Res Int 2022 11;2022:5908938. Epub 2022 Apr 11.

Parul Institute of Applied Sciences, Parul University, Vadodara, 391760 Gujarat, India.

The three main intestinal helminth infections (IHIs), ascariasis, trichuriasis, and hookworm, are common clinical disorders worldwide. These IHIs are more prevalent in tropics and subtropical countries especially in developing countries like sub-Saharan Africa responsible for morbidity, mortality, and physical as well as intellectual growth retardation in children. In Ethiopia, the burden of IHIs appears in all ages mainly due to factors like lack of education, low socio-economic status, and inadequate supply of drugs and proper awareness. Read More

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Prevalence of hookworm infections among stray dogs and molecular identification of hookworm species for the first time in Bangladesh.

Vet Parasitol Reg Stud Reports 2022 05 13;30:100719. Epub 2022 Mar 13.

Department of Parasitology, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh. Electronic address:

Hookworms are the most common and voracious blood-sucking parasites of the small intestines of mammalian hosts such as dogs, cats, ruminants and humans. Canine hookworms are endemic in the Southeast Asian countries including Bangladesh. There is scarcity of information on the prevalence of hookworms of stray dogs in Bangladesh. Read More

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Bacterial and parasite co-infection in Mexican golden trout (Oncorhynchus chrysogaster) by Aeromonas bestiarum, Aeromonas sobria, Plesiomonas shigelloides and Ichthyobodo necator.

BMC Vet Res 2022 Apr 12;18(1):137. Epub 2022 Apr 12.

Centro Multidisciplinario de Estudios en Biotecnología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Mexico.

Background: Bacterial infections are responsible of high economic losses in aquaculture. Mexican golden trout (Oncorhynchus chrysogaster) is a threatened native trout species that has been introduced in aquaculture both for species conservation and breeding for production and for which no studies of bacterial infections have been reported.

Case Presentation: Fish from juvenile stages of Mexican golden trout showed an infectious outbreak in a farm in co-culture with rainbow trout (Oncorhynchus mykiss), showing external puntiform red lesions around the mouth and caudal pedunculus resembling furuncles by Aeromonas spp. Read More

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Prevalence and associated risk factors of soil-transmitted helminth infections in Kandahar, Afghanistan.

BMC Infect Dis 2022 Apr 11;22(1):361. Epub 2022 Apr 11.

Mahidol Oxford Tropical Medicine Clinical Research Unit (MORU), Mahidol University, Bangkok, Thailand.

Background: Soil-transmitted helminth (STH) infections are still a major health problem, especially in resource-limited countries. The community-based prevalence of STH is unknown in Afghanistan. Main objectives of this study were to estimate the prevalence and associated factors of STH among children in Daman district of Kandahar province in Afghanistan. Read More

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Prevalence, intensity of infection and associated risk factors of soil-transmitted helminth infections among school children at Tachgayint woreda, Northcentral Ethiopia.

PLoS One 2022 8;17(4):e0266333. Epub 2022 Apr 8.

Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

Background: Soil-transmitted helminths (STH) are one of the most common infections affecting underprivileged populations in low- and middle-income countries. Ascaris lumbricoides, Trichuris trichiura, and hookworm are the three main species that infect people. School children are the most vulnerable groups for STH infections due to their practice of walking and playing barefoot, poor personal hygiene, and environmental sanitation. Read More

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Nutritional status, intestinal parasitic infections, and socio-environmental conditions in Mbyá-guaraní children: The current situation in communities in central Misiones, Argentina.

Am J Hum Biol 2022 Apr 7:e23749. Epub 2022 Apr 7.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE-CONICET-UNLP), Buenos Aires, Argentina.

Objectives: Our previous research in Mbyá-guaraní communities of central Misiones showed high levels of growth stunting and intestinal parasites in children, as well as associations between these variables and deficient sanitary conditions. New studies were necessary to update the present health status of the previously studied Mbyá populations after around two decades. Therefore, we evaluated the current nutritional status, intestinal parasites, and socio-environmental conditions among Mbyá-guaraní children from these communities. Read More

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Hookworm-induced refractory gastric ulcer (with video).

Gastrointest Endosc 2022 Jul 4;96(1):158-159. Epub 2022 Apr 4.

Department of Gastroenterology and Hepatology, Xiamen Branch of Zhongshan Hospital, Fudan University, Xiamen, Fujian, China; Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.

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Prevalence of Soil-Transmitted Helminthes and Associated Risk Factors Among People of Ethiopia: A Systematic Review and Meta-Analysis.

Infect Dis (Auckl) 2022 26;15:11786337211055437. Epub 2022 Mar 26.

Department of Biology, Debark University College of Natural and Computational Science, Debark, Ethiopia.

Background: A Soil-transmitted helminthic infection (STHIs) remains a notable health problem in resource-limited countries.

Objective: This systematic review and meta-analysis aimed to determine the overall prevalence of STH infections in Ethiopia.

Methods: Articles written in English were searched from online public databases. Read More

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Environmental contamination with parasites in selected rural farms in the Philippines: impacts of farming practices on leafy greens food safety.

Parasitology 2022 04 6;149(4):482-489. Epub 2021 Dec 6.

Parasitology Research Laboratory, Animal Biology Division, Institute of Biological Sciences, University of the Philippines Los Baňos, College 4031, Laguna, Philippines.

Fresh vegetables are an important part of a healthy diet, however, they can also be agents of transmission of intestinal parasites. This study aimed to evaluate the presence of parasite contamination in vegetable farms as a source of transmission in selected rural communities in Laguna, Philippines. A total of 168 vegetable, 55 soil and 15 water samples collected from four selected farms and a reference farm were processed through various standard parasitological techniques. Read More

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Development of a peptide vaccine against hookworm infection: Immunogenicity, efficacy, and immune correlates of protection.

J Allergy Clin Immunol 2022 Mar 9. Epub 2022 Mar 9.

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia.

Background: Approximately 400 million individuals are infected with hookworms globally. Protective vaccines are needed to prevent reinfections, which often occur after drug treatment in endemic areas. Ideal vaccines are highly efficacious and well tolerated, and do not present risks to patient safety. Read More

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[Surveillance of soil-borne nematodiasis in Yancheng City from 2016 to 2020].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Oct;34(1):92-94

Yancheng Municipal Center for Disease Control and Prevention, Yancheng, Jiangsu 224000, China.

Objective: To understand the prevalence of soil-transmitted nematode infections in Yancheng City from 2016 to 2020, so as to provide insights into the development of the scheme for further soil-transmitted nematodiasis surveillance.

Methods: Soil-borne nematode infections were detected using the modified Kato-Katz method (two slides for one sample) among the permanent residents living in Yancheng City from 2016 to 2020, and infection was additionally detected among children at ages of 12 years and lower using the adhesive cellophane-tape perianal swab method. The prevalence and intensity of human soil-borne nematode and infections were descriptively analyzed. Read More

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October 2021

[Surveillance of human soil-transmitted nematodiasis in Jurong City from 2016 to 2020].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2021 Jul;34(1):89-91

Jurong Center for Disease Control and Prevention, Jurong, Jiangsu 212400, China.

Objective: To investigate the prevalence of soil-transmitted nematode human infections in Jurong City from 2016 to 2020, so as to provide the scientific evidence for formulating the control strategy.

Methods: During the period from 2016 to 2020, the permanent residents at ages of over 3 years living in Jurong City were selected as the study subjects. Stool samples were collected for the detection of soil-transmitted nematode eggs using the modified Kato-Katz thick smear method (two detections for one stool sample), and the species of hookworm was identified in stool-positive stool samples using the culture method. Read More

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