3,323 results match your criteria Hookworms

Cross-sectional study on intestinal parasite infections in different ecological zones of the Department of La Paz, Bolivia.

One Health 2021 Dec 27;13:100271. Epub 2021 May 27.

Dipartimento di Sanità Pubblica e Malattie Infettive, Università di Roma Sapienza, Roma, Italy.

We performed a cross-sectional parasitological survey to assess the prevalence of protozoa and helminth infection among 275 school-age children (SAC) living in rural and peri-urban areas located in different ecological zones of the Department of La Paz, Bolivia. Public health activities for the control of STH, based on the biannual administration of mebendazole to preschool and school children are implemented at national level since 1986. We found an overall prevalence of 82. Read More

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December 2021

Hookworm treatment induces a decrease of suppressive regulatory T cell associated with a Th2 inflammatory response.

PLoS One 2021 10;16(6):e0252921. Epub 2021 Jun 10.

Clinic of Immunoallergology, CHU Brugmann, ULB, Brussels, Belgium.

Background: Like other helminths, hookworms (HW) induce a regulatory immune response able to modulate and dampen reactivity of the host to antigens. No data about the evolution of the immune response after treatment are available. We aim to phenotype the regulatory immune response during natural HW infection and its evolution after treatment. Read More

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Burden of intestinal parasitic infections among pregnant women in Ethiopia: a systematic review and meta-analysis.

Infection 2021 Jun 10. Epub 2021 Jun 10.

School of Medical Laboratory Sciences, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Comprehensive nationwide data on prevalence and distribution of intestinal parasites (IPIs) among pregnant women are lacking. Therefore, the aim of this study was to provide pooled prevalence estimate, prevalence in different regions and species-specific IPIs among pregnant women in Ethiopia.

Methods: The search was carried out in Medline via PubMed, Scopus, Science Direct, Web of Science and Google Scholar on published and unpublished data between 2008 and Sep 2020 for studies describing rate of IPIs among pregnant women in Ethiopian. Read More

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Utilization of Deworming Drugs and Its Individual and Community Level Predictors among Pregnant Married Women in Cameroon: A Multilevel Modeling.

Biomed Res Int 2021 12;2021:6645336. Epub 2021 May 12.

University of Parakou, Faculty of Medicine, Parakou, Benin.

Background: Although deworming pregnant women is one of the strategies to reduce parasites (roundworms and hookworms) causing anemia and related perinatal and maternal complications, utilization of deworming medication among pregnant women in Cameroon is suboptimal. Comprehensive assessment of individual, household (including women's autonomy), and community-level factors associated with utilization of deworming medication has not been done so far. Therefore, we investigated the individual/household and community-level factors associated with deworming among pregnant married women in Cameroon. Read More

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Ivermectin gegen Hakenwurm - und Coronavirus?

MMW Fortschr Med 2021 06;163(11):27-28

Facharzt für Innere Medizin, München, Deutschland.

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Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.

J Biol Chem 2021 May 27;297(1):100834. Epub 2021 May 27.

Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, QLD, Australia. Electronic address:

The prevalence of autoimmune diseases is on the rise globally. Currently, autoimmunity presents in over 100 different forms and affects around 9% of the world's population. Current treatments available for autoimmune diseases are inadequate, expensive, and tend to focus on symptom management rather than cure. Read More

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Intestinal parasites and risk factors in dogs and cats from Rio de Janeiro, Brazil.

Vet Parasitol Reg Stud Reports 2021 Apr 6;24:100552. Epub 2021 Mar 6.

Toxoplasmosis and other Protozoan Diseases Laboratory, Oswaldo Cruz Institute/Fiocruz, Brazil.

The urban populations of pets, mainly dogs and cats, have been growing in recent years and, consequently, human-animal relationships have become increasingly closer. However, pets are vulnerable to infection by various parasites, as well are their owners due to the zoonotic potential of these agents. This study aimed to assess the frequency and risk factors of intestinal parasites in dogs and cats attended at the Municipal Institute of Veterinary Medicine Jorge Vaitsman, Rio de Janeiro, Brazil, as well as georeferencing the parasitized animals. Read More

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First report on occurrence of zoonotic helminth Toxocara canis, Toxascaris leonina and Ancylostoma caninum in domestic dogs from province of Djelfa, Algeria.

Ann Parasitol 2021 ;67(1):111-116

Laboratory of Exploration and Valorisation of Steppic Ecosystems, Faculty of Nature and Life Sciences, University of Djelfa, Moudjbara Road, BP 3117, Djelfa, Algeria.

A total of 85 faecal samples of domestic dogs were collected from six localities, including Birine, Sidi Ladjel, Dar Chioukh, Aïn Maâbed, Aïn El-Ibel and Djelfa city from province of Djelfa, Algeria. Samples were tested for presence of Toxocara canis, Toxascaris leonina and Ancylostoma caninum eggs by formol-ether concentration and flotation techniques. Microscopic examination revealed an infection rate of 9. Read More

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Effectiveness of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio Plus) for the treatment of larval and immature adult stages of Ancylostoma caninum in experimentally infected dogs.

Parasit Vectors 2021 May 17;14(1):255. Epub 2021 May 17.

East Tennessee Clinical Research Inc., Rockwood, TN, USA.

Background: The hookworm, Ancylostoma caninum, is a common and important zoonotic intestinal nematode parasite that infects dogs globally. Both the immature and adult stages of A. caninum ingest large volumes of blood during the feeding process and can cause severe anemia and death in young dogs, even before patent infections can be diagnosed using routine faecal examination methods. Read More

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Intestinal Helminth Infections and Associated Risk Factors among School-Aged Children of Bamendjou Community, West Region of Cameroon.

J Parasitol Res 2021 23;2021:6665586. Epub 2021 Apr 23.

Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon.

Background: Infection with intestinal nematodes is of major public health concern worldwide, and school-age children and pregnant women are the principal victims. The present study was undertaken to provide baseline information on the status of gastrointestinal nematodes among school-age children in Bamendjou. . Read More

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Differential drivers of intraspecific and interspecific competition during malaria-helminth co-infection.

Parasitology 2021 May 11:1-10. Epub 2021 May 11.

Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Ontario, Canada.

Both initial infectious dose and the presence of co-infecting parasites can impact the within-host dynamics of infection. In mice infected with malaria, increasing initial infectious doses reduced the time it took for within-host malaria replication to peak, but also reduced the magnitude of this within-host replication. When mice were also co-infected with hookworms (helminths that reduce the availability of red blood cells (RBCs) to malaria parasites), peak within-host malaria replication was delayed. Read More

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Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach.

Front Cell Infect Microbiol 2021 22;11:639573. Epub 2021 Apr 22.

Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. and have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. Read More

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Prevalence of intestinal parasites in dogs from public shelters in Serbia.

Comp Immunol Microbiol Infect Dis 2021 Jun 22;76:101653. Epub 2021 Apr 22.

Department of Parasitology, Faculty of Veterinary Medicine, University of Belgrade, Serbia. Electronic address:

Data on endoparasitic infections in dogs from dog shelters in Southeastern Europe are limited; thus, this study aimed to add to the existing knowledge on this topic by reporting on the prevalence of intestinal parasites in dogs from public dog shelters in the Republic of Serbia. In 2017 and 2018, individual and pooled fecal samples, were collected from 1267 dogs from six shelters. All samples were qualitatively examined for parasites using flotation tests. Read More

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Identification of antigenic linear peptides in the soil-transmitted helminth and Schistosoma mansoni proteome.

PLoS Negl Trop Dis 2021 Apr 28;15(4):e0009369. Epub 2021 Apr 28.

Global Public Health R&D, Janssen Pharmaceutica NV, Beerse, Belgium.

The scientific community identified non stool-based biomarkers as the way forward to support soil-transmitted helminth (STH; Ascaris lumbricoides, Trichuris trichiura and the hookworms Ancylostoma duodenale and Necator americanus) and schistosome (S. mansoni and S. haematobium) deworming programs. Read More

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Edaphic and climatic factors influence on the distribution of soil transmitted helminths in Kogi East, Nigeria.

Sci Rep 2021 Apr 19;11(1):8490. Epub 2021 Apr 19.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, 22511, Egypt.

The need for a reliable risk map in the control of soil-transmitted helminths (STHs) in Kogi East, North Central Nigeria is very important. This study was carried out to determine the effect of environmental risk factors on geospatial distribution of STHs. Epidemiological data were obtained from a district-wide survey conducted in 2018 in Kogi East. Read More

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Evaluation of the Allplex™ GI-Helminth(I) Assay, the first marketed multiplex PCR for helminth diagnosis.

Parasite 2021 2;28:33. Epub 2021 Apr 2.

Université de Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé Environnement Travail), UMRS 1085, 35000 Rennes, France.

Molecular biology has been gaining more importance in parasitology. Recently, a commercial multiplex PCR assay detecting helminths was marketed: the Allplex™ GI-Helminth(I) Assay. It targets Ancylostoma spp. Read More

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Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications.

Int J Mol Sci 2021 Mar 25;22(7). Epub 2021 Mar 25.

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.

The integrin αIIbβ3 is the most abundant integrin on platelets. Upon platelet activation, the integrin changes its conformation (inside-out signalling) and outside-in signalling takes place leading to platelet spreading, platelet aggregation and thrombus formation. Bloodsucking parasites such as mosquitoes, leeches and ticks express anticoagulant and antiplatelet proteins, which represent major sources of lead compounds for the development of useful therapeutic agents for the treatment of haemostatic disorders or cardiovascular diseases. Read More

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Prevalence, Risk Factors, and Coinfection of Urogenital Schistosomiasis and Soil-Transmitted Helminthiasis among Primary School Children in Biase, Southern Nigeria.

J Parasitol Res 2021 13;2021:6618394. Epub 2021 Mar 13.

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Al Beheira, Egypt.

Schistosomiasis and soil-transmitted helminthiasis (STH) are neglected tropical diseases (NTDs) that cause chronic infections and ill health. The study was carried out to determine the current infection status and risk factors associated with and soil-transmitted helminth (STH) coinfection among school children in Biase Local Government Area (LGA), Cross River State, Nigeria. A cross-sectional study was carried out. Read More

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Strongyloides and hookworms co-infection in a liver transplant patient.

IDCases 2021 10;24:e01060. Epub 2021 Mar 10.

Infectious Disease Division, Department of Internal Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

We here present a female patient who is a recipient of liver transplantation from a cadaveric donor. She developed abdominal pain, nausea, vomiting, and diarrhea for two weeks of duration, after four months of the transplant. Upper gastrointestinal (GI) endoscopy and stool analysis for ova and parasite showed Necator americanus / Ancylostoma duodenale (Hookworm) ova /larvae and Larvae. Read More

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Canine intestinal parasitic infections and soil contamination by spp. in selected areas of Sri Lanka.

Trop Parasitol 2020 Jul-Dec;10(2):114-119. Epub 2021 Jan 25.

Department of Parasitology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Introduction: Contaminated environment with canine parasitic eggs is the main source for toxocariasis and other geohelminth infections of humans. This study aimed to determine the prevalence and associated risk factors for intestinal parasitic infections in dogs and the degree of soil contamination with eggs in Kandy and Gampaha districts in Sri Lanka.

Methods: A total of 188 fecal samples from both stray and domestic owned dogs from Gampaha district and Kandy district were collected. Read More

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January 2021

A 3-year retrospective analysis of canine intestinal parasites: fecal testing positivity by age, U.S. geographical region and reason for veterinary visit.

Parasit Vectors 2021 Mar 20;14(1):173. Epub 2021 Mar 20.

IDEXX Laboratories, Inc., One IDEXX Drive, Westbrook, ME, USA.

Background: Canine life stage is a key factor in parasite prevalence as clinical signs associated with parasitism are more common in pups. In adult dogs, health status and geographical region may also play a role in parasite prevalence. The purpose of this study was to evaluate fecal test results using zinc sulfate flotation by centrifugation combined with fecal antigen testing for hookworms (Ancylostoma spp. Read More

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Outbreak of cutaneous larva migrans among Danish students at a high school on Zanzibar.

Travel Med Infect Dis 2021 May-Jun;41:102008. Epub 2021 Mar 8.

Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark. Electronic address:

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Soil transmitted helminth infection in primary school children varies with ecozone in the Ngorongoro Conservation Area, Tanzania.

Trop Med Health 2021 Mar 10;49(1):22. Epub 2021 Mar 10.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Background: Soil-transmitted helminthiasis is a neglected tropical disease, thriving in environments of poverty and disadvantage. Our objective was to determine the prevalence and intensity of four soil transmitted helminths (STH) among primary school children in the Ngorongoro Conservation Area (NCA), Tanzania.

Methods: A cross-sectional study was performed between May 15 and June 2, 2014. Read More

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A netrin domain-containing protein secreted by the human hookworm Necator americanus protects against CD4 T cell transfer colitis.

Transl Res 2021 Jun 4;232:88-102. Epub 2021 Mar 4.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia. Electronic address:

The symbiotic relationships shared between humans and their gastrointestinal parasites present opportunities to discover novel therapies for inflammatory diseases. A prime example of this phenomenon is the interaction of humans and roundworms such as the hookworm, Necator americanus. Epidemiological observations, animal studies and clinical trials using experimental human hookworm infection show that hookworms can suppress inflammation in a safe and well-tolerated way, and that the key to their immunomodulatory properties lies within their secreted proteome. Read More

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Insight into One Health Approach: Endoparasite Infections in Captive Wildlife in Bangladesh.

Pathogens 2021 Feb 23;10(2). Epub 2021 Feb 23.

International Parasite Resource Bank, Cheongju 28644, Korea.

: Endoparasites in captive wildlife might pose a threat to public health; however, very few studies have been conducted on this issue, and much remains to be learned, especially in limited-resource settings. This study aimed to investigate endoparasites of captive wildlife in Bangladesh. Perception and understanding of veterinarians regarding one health and zoonoses were also assessed. Read More

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February 2021

and Other Parasitic Enteropathogens: More Commonly Found in Owned Cats with Gastrointestinal Signs Than in Clinically Healthy Ones.

Pathogens 2021 Feb 13;10(2). Epub 2021 Feb 13.

Department of Parasitology and Parasitic Diseases, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania.

Intestinal parasites are involved in the health and wellbeing of cats and some of them, due to their zoonotic potential, represent a problem for public health. This study aimed to assess the prevalence of parasitic infections in cats with gastrointestinal signs. Fecal samples collected from 137 cats were analyzed by the flotation method using a sodium chloride saturated solution. Read More

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February 2021

Perceptions of dog owners towards canine gastrointestinal parasitism and associated human health risk in Southeast Queensland.

One Health 2021 Jun 16;12:100226. Epub 2021 Feb 16.

The University of Queensland, School of Veterinary Science, Veterinary Parasitology & Ecology, Gatton 4343, Queensland, Australia.

Canine companion animals can carry a number of zoonotic parasites which can adversely impact both human and animal health. Previous studies in Australia indicated that while parasitic infections in dogs are still common and there is variability in the awareness and perception of zoonotic risks among pet owners, the likely contribution of sociodemographic factors to the variation in awareness and perception needs to be further explored. The primary objective of this study is to quantify the relationship between dog owners' knowledge and beliefs about dog parasites and their sociodemographic characteristics. Read More

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Preparation of Larvae for the Study of Host Skin Response.

Bio Protoc 2020 Dec 20;10(24):e3849. Epub 2020 Dec 20.

Laboratory of intestinal immunology, Department of Immunology and Pathology, Monash University, Melbourne, VIC 3004, Australia.

Hookworms are skin penetrating parasites, however in the laboratory the hookworm model , the parasite is traditionally administered subcutaneously bypassing the skin (epidermis and dermis). Here, we describe two complementary approaches for infecting mice with in order to study the skin immune responses. The first approach employs a skin percutaneous injection that is poorly efficient with the laboratory strain of the parasite in mice, but represents a natural infection. Read More

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December 2020

Intestinal helminths as predictors of some malaria clinical outcomes and IL-1β levels in outpatients attending two public hospitals in Bamenda, North West Cameroon.

PLoS Negl Trop Dis 2021 03 2;15(3):e0009174. Epub 2021 Mar 2.

Department of Biology, Higher Teachers Training College, University of Bamenda, Bambili, North West Region, Cameroon.

This study aimed at determining the impact of intestinal helminths on malaria parasitaemia, anaemia and pyrexia considering the levels of IL-1β among outpatients in Bamenda. A cohort of 358 consented participants aged three (3) years and above, both males and females on malaria consultation were recruited in the study. At enrolment, patients' axillary body temperatures were measured and recorded. Read More

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Socioenvironmental Factors Influencing Distribution and Intensity of Soil-Transmitted Helminthiasis in the Brazilian Amazon: Challenges for the 2030 Agenda.

J Trop Med 2021 4;2021:6610181. Epub 2021 Feb 4.

Laboratório de Epidemiologia e Sistemática Molecular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Soil-transmitted helminthiasis (STHs) are poverty-related diseases with high prevalence rates in developing countries. The present study aims to describe the epidemiological scenario of STHs in an urban population in the Brazilian Amazon. A cross-sectional survey ( = 349 children aged 1-15 years) was carried out to obtain faecal samples and sociodemographic and sanitation data. Read More

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February 2021