3,069 results match your criteria Hookworms


A highly expressed intestinal cysteine protease of Ancylostoma ceylanicum protects vaccinated hamsters from hookworm infection.

PLoS Negl Trop Dis 2019 Apr 22;13(4):e0007345. Epub 2019 Apr 22.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

Background: Human hookworms (Necator americanus, Ancylostoma duodenale, and Ancylostoma ceylanicum) are intestinal blood-feeding parasites that infect ~500 million people worldwide and are among the leading causes of iron-deficiency anemia in the developing world. Drugs are useful against hookworm infections, but hookworms rapidly reinfect people, and the parasites can develop drug resistance. Therefore, having a hookworm vaccine would be of tremendous benefit. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007345DOI Listing

Parasitism Elicits a Stress Response That Allocates Resources for Immune Function in South American Fur Seals (Arctocephalus australis).

Physiol Biochem Zool 2019 May/Jun;92(3):326-338

Parasites can cause chronic stress in some animal species, and this type of stress response has been associated with adverse consequences for the host. In order to know whether parasitism elicited a stress response associated with decreased host fitness, hookworm (Uncinaria sp.) infection was studied in a colony of South American fur seals (Arctocephalus australis) in which hookworms infect nearly all pups born in a reproductive season. Read More

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http://dx.doi.org/10.1086/702960DOI Listing

Intestinal parasite infections in dogs affected by multicentric lymphoma and undergoing chemotherapy.

Comp Immunol Microbiol Infect Dis 2019 Apr 19;63:81-86. Epub 2019 Jan 19.

Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge 2, 56124, Pisa, Italy. Electronic address:

Prevalence and species composition of intestinal parasites were evaluated in dogs affected by high-grade multicentric lymphoma and undergoing chemotherapy and in control healthy dogs. Obtained data were statistically analyzed. The overall prevalence of intestinal parasite infections was 33. Read More

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http://dx.doi.org/10.1016/j.cimid.2019.01.006DOI Listing

Current status of intestinal parasitic infections and associated factors among primary school children in Birbir town, Southern Ethiopia.

BMC Infect Dis 2019 Mar 19;19(1):270. Epub 2019 Mar 19.

Department of Medical Laboratory Science, Arba Minch University, Arba Minch, Ethiopia.

Background: Intestinal parasites still pose major public health problems in developing countries like Ethiopia. Local epidemiological data is indispensable in order to design and monitor prevention and control strategies. Therefore the present study aimed to assess the prevalence of intestinal parasitic infections and associated factors among students at Birbir town, Southern Ethiopia. Read More

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http://dx.doi.org/10.1186/s12879-019-3879-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425597PMC
March 2019
2.613 Impact Factor

Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity.

J Med Chem 2019 Apr 28;62(7):3367-3380. Epub 2019 Mar 28.

School of Pharmaceutical Sciences , Nanjing Tech University , No. 30 South Puzhu Road , Nanjing 211816 , P. R. China.

A phenotypic screen of two different libraries of small molecules against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1 H-pyrazole-5-carboxamide derivatives. Medicinal chemistry optimization targeted modifications of the left-hand side, middle section, and right-hand side of the hybrid structure of these two hits to elucidate the structure-activity relationship (SAR). Initial SAR around these hits allowed for the iterative and directed assembly of a focused set of 30 analogues of their hybrid structure. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01790DOI Listing

The Effectiveness of Triple Dose Albendazole in Treating Soil Transmitted Helminths Infection.

J Parasitol Res 2019 4;2019:6438497. Epub 2019 Feb 4.

Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Soil transmitted helminths (STH) infection is a major health problem in tropical countries such as Indonesia. Albendazole is an effective and widely used anthelmintic agent to treat STH; however, it is not effective towards and its effectiveness varies between populations. Hence, we conducted a study to determine the effectiveness of triple dose albendazole in children of Perobatang village, Southwest Sumba, Indonesia. Read More

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http://dx.doi.org/10.1155/2019/6438497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378773PMC
February 2019
1 Read

Establishment of a Tm-shift Method for Detection of Cat-Derived Hookworms.

Korean J Parasitol 2019 Feb 26;57(1):9-15. Epub 2019 Feb 26.

Guangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510542, P. R. China.

Melting temperature shift (Tm-shift) is a new detection method that analyze the melting curve on real-time PCR thermocycler using SYBR Green I fluorescent dye. To establish a Tm-shift method for the detection of Ancylostoma ceylanicum and A. tubaeforme in cats, specific primers, with GC tail of unequal length attached to their 5 ́ end, were designed based on 2 SNP loci (ITS101 and ITS296) of the internal transcribed spacer 1 (ITS1) sequences. Read More

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http://dx.doi.org/10.3347/kjp.2019.57.1.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409220PMC
February 2019
2 Reads

Molecular identification of zoonotic hookworms in dogs from four counties of Kenya.

J Helminthol 2019 Feb 28:1-8. Epub 2019 Feb 28.

Parasitology Unit,University of Hohenheim,Stuttgart,Germany.

All canine hookworms are known to be zoonotic, causing infections ranging from transient skin irritations to prolonged 'creeping eruptions', eosinophilic enteritis and even patent intestinal infections. There is little information on canine hookworm species and their public health significance in sub-Saharan Africa. This study determined the prevalence and species of hookworms in dogs from different climatic zones of Kenya. Read More

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http://dx.doi.org/10.1017/S0022149X1900018XDOI Listing
February 2019

Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum.

Int J Parasitol 2019 Apr 14;49(5):397-406. Epub 2019 Feb 14.

Department of Microbiology, Immunology, and Tropical Medicine, Ross Hall, 2300 I St. NW, The George Washington University, Washington, DC 20052, USA. Electronic address:

Soil-transmitted nematodes infect over a billion people and place several billion more at risk of infection. Hookworm disease is the most significant of these soil-transmitted nematodes, with over 500 million people infected. Hookworm infection can result in debilitating and sometimes fatal iron-deficiency anemia, which is particularly devastating in children and pregnant women. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456372PMC
April 2019
2 Reads

Genetic Markers of Benzimidazole Resistance among Human Hookworms () in Kintampo North Municipality, Ghana.

Am J Trop Med Hyg 2019 Feb;100(2):351-356

Yale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.

Hookworm infection causes anemia, malnutrition, and growth delay, especially in children living in sub-Saharan Africa. The World Health Organization recommends periodic mass drug administration (MDA) of anthelminthics to school-age children (SAC) as a means of reducing morbidity. Recently, questions have been raised about the effectiveness of MDA as a global control strategy for hookworms and other soil-transmitted helminths (STHs). Read More

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http://dx.doi.org/10.4269/ajtmh.18-0727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367626PMC
February 2019
2.699 Impact Factor

[Prevalence and intensity of geohelminths infection characterizing the socio-cultural and environmental factors that affect the infection of school children, Paraguay, 2015].

Rev Chilena Infectol 2018 ;35(5):501-508

Organización Panamericana de la Salud, Asunción, Paraguay.

Introduction: Currently, Paraguay has no data on the prevalence of soil-transmitted geohelminth infection in schoolchildren aged 6 to 12 years.

Aim: To determine the prevalence and intensity of infection by Ascaris lumbricoides, Trichuris trichiura and hookworms and the socio-cultural-environmental characteristics of the affected population.

Methods: Descriptive, cross-sectional study, in three semi-tropical climatic zones: continental, semi steppe and humid. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500501DOI Listing
January 2018
3 Reads

Magnitude of Intestinal Parasitosis and Associated Factors in Rural School Children, Northwest Ethiopia.

Ethiop J Health Sci 2019 Jan;29(1):923-928

Department of Medical Parasitology and Vector Biology, Mekelle University, Ethiopia.

Background: Intestinal parasitoses are among the most commonly encountered infections among school children in poor regions of the world. Up to 600 million school children are living in areas where there is high transmission of parasitic worms. Intestinal parasitic infection has been found to have a great effect on nutritional and cognitive status, school absenteeism and dropouts among school age children. Read More

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http://dx.doi.org/10.4314/ejhs.v29i1.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341440PMC
January 2019
6 Reads

Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism.

Parasitol Res 2019 Mar 29;118(3):837-849. Epub 2019 Jan 29.

Departamento de Parasitologia, L4 237, Laboratório de Parasitologia Molecular, Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Mass drug administration has been implicated as the major cause of drug resistance in nematodes of ruminants. Single-nucleotide polymorphisms (SNPs) at codons 167, 198, and 200 of the beta-tubulin isotype 1 gene are associated with albendazole resistance mechanisms. Although drug resistance is suspected to occur in nematodes of the same order, at present, there is no evidence of a strong correlation between these canonical SNPs and albendazole resistance in hookworms. Read More

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http://link.springer.com/10.1007/s00436-019-06218-9
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http://dx.doi.org/10.1007/s00436-019-06218-9DOI Listing
March 2019
1 Read

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.

Infect Immun 2019 Apr 25;87(4). Epub 2019 Mar 25.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral blood mononuclear cells, we demonstrated that low-molecular-weight metabolites derived from both somatic extracts (LMWM-SE) and excretory-secretory products (LMWM-ESP) of the hookworm, , display anti-inflammatory properties. Administration to mice of LMWM-ESP as well as sequentially extracted fractions of LMWM-SE using both methanol (SE-MeOH) and hexane-dichloromethane-acetonitrile (SE-HDA) resulted in significant protection against T cell-mediated immunopathology, clinical signs of colitis, and impaired histological colon architecture. Read More

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http://dx.doi.org/10.1128/IAI.00851-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434117PMC
April 2019
12 Reads
3.731 Impact Factor

Migration of the people and parasites: facts from survey of 5511 foreigners.

Authors:
Michal Giboda

Cas Lek Cesk 2018 Dec;157(7):373-379

In the course of the years 1983-1989, 5511 foreigners in the age of 20 to 40 years old from 87 countries were examined for human parasites. Everyone was examined within 1 months of arrival in the Czech Republic in the Active Case Detection (ACD) program. The intensity of infection was measured in those parasites which do not reproduce in the human body. Read More

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December 2018
4 Reads

Malaria and Geohelminthiasis Coinfections in Expectant Women: Effect on Maternal Health and Birth Outcomes in a Malaria Endemic Region in Kenya.

J Parasitol Res 2018 29;2018:2613484. Epub 2018 Nov 29.

Department of Clinical Medicine, Jomo Kenyatta University of Agriculture and Technology, P.O. Box 62000, Nairobi, Kenya.

Geohelminthiasis and malaria coinfections in pregnancy are common in sub-Saharan Africa. The consequences of the disease combination on maternal health and birth outcomes are poorly understood. For a better understanding of this coinfection in expectant mothers, a cross-sectional study was carried out to evaluate the effect of the coinfection on maternal health and birth outcomes in expectant mothers in Bungoma County, Kenya. Read More

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http://dx.doi.org/10.1155/2018/2613484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304650PMC
November 2018
4 Reads

Prevalence of parasitic contamination of raw vegetables in Nakhon Si Thammarat province, southern Thailand.

BMC Public Health 2019 Jan 8;19(1):34. Epub 2019 Jan 8.

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.

Background: Soil-transmitted helminth (STH) infections are major public health problems in poor and developing countries that require fecal contamination of the environment for transmission. The consumption of raw vegetables without proper washing is one of the main routes of intestinal parasite acquisition. Therefore, this study was designed to detect the prevalence of intestinal parasitic contamination in commonly consumed raw vegetables sold in three central open-air markets in Nakhon Si Thammarat province, southern Thailand. Read More

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http://dx.doi.org/10.1186/s12889-018-6358-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323832PMC
January 2019
3 Reads

Helminth infections of wild European gray wolves (Canis lupus Linnaeus, 1758) in Lower Saxony, Germany, and comparison to captive wolves.

Parasitol Res 2019 Feb 4;118(2):701-706. Epub 2019 Jan 4.

Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Bünteweg 17, 30159, Hannover, Germany.

This study aimed to investigate the endoparasite fauna of wild European gray wolves, which are currently recolonizing Germany. In total, 69 fecal samples of wild wolves were collected in Lower Saxony, Germany, from 2013 to 2015, analyzed by the sedimentation-flotation and McMaster techniques and compared to previous results on captive European Gray wolves living in zoological gardens in Germany. In addition to coproscopy, taeniid-positive samples from wild as well as captive wolves were differentiated by amplification and sequencing of small subunit ribosomal RNA (SSU rRNA) and NADH dehydrogenase 1 (nad1) gene fragments. Read More

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http://dx.doi.org/10.1007/s00436-018-6181-3DOI Listing
February 2019
1 Read

Prevalence and associated factors of and soil transmitted helminth infections among pregnant women in Osun state, Nigeria.

Afr Health Sci 2018 Sep;18(3):542-551

Ladoke Akintola University of Technology, PMB 4400, Osogbo, Nigeria.

Background: and soil transmitted helminth (STHs) infection are widespread in sub-Sahara Africa, where co-infection is also common. This study assessed the prevalence of these infections and their risk factors among pregnant women in Osogbo, Nigeria.

Methods: A total of 200 pregnant women attending the antenatal clinic were recruited. Read More

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http://dx.doi.org/10.4314/ahs.v18i3.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307031PMC
September 2018

Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development.

J Med Chem 2019 Jan 7;62(2):1036-1053. Epub 2019 Jan 7.

School of Pharmaceutical Sciences , Nanjing Tech University , No. 30, South Puzhu Road , Nanjing 211816 , P. R. China.

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC value of 0.03 μM while displaying good selectivity, with an IC of 37.9 μM for cytotoxicity. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01789DOI Listing
January 2019
2 Reads

Intestinal parasites and lungworms in stray, shelter and privately owned cats of Switzerland.

Parasitol Int 2019 Apr 12;69:75-81. Epub 2018 Dec 12.

University of Zurich, Vetsuisse Faculty, Institute of Parasitology, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

Endoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples additionally by the Baermann technique. Read More

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http://dx.doi.org/10.1016/j.parint.2018.12.005DOI Listing
April 2019
2 Reads

Mitochondrial DNA reveals species composition and phylogenetic relationships of hookworms in northeastern Brazil.

Infect Genet Evol 2019 Mar 30;68:105-112. Epub 2018 Nov 30.

Laboratory of Epidemiology and Molecular Systematics, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; Oswaldo Cruz Foundation, Teresina, Piauí, Brazil. Electronic address:

Hookworm infection persists focally in rural communities in Brazil. In this study, we analyze the mitochondrial nucleotide sequences obtained from hookworms infecting humans in order to characterize species composition and assess their genetic diversity and phylogenetic relationships. Field expeditions and cross-sectional surveys were carried out in three Brazilian municipalities from 2013 to 2017: Nossa Senhora de Nazaré (n = 605) and Teresina (n = 297), in the state of Piauí, and Russas (n = 213) in the State of Ceará. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183071
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http://dx.doi.org/10.1016/j.meegid.2018.11.018DOI Listing
March 2019
18 Reads

A randomized, blinded, controlled, multi-centered field study assessing the treatment of gastrointestinal nematode infections in cats with fluralaner plus moxidectin spot-on solution (Bravecto® Plus).

Parasit Vectors 2018 Nov 19;11(1):589. Epub 2018 Nov 19.

MSD Animal Health Innovation GmbH, Zur Propstei, 55270, Schwabenheim, Germany.

Background: A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) was developed for the treatment of nematode infections as well as providing 12 weeks of protection against insect and acarine parasites in cats. The effectiveness and safety of this product against feline gastrointestinal nematodes was assessed in naturally-infested, client-owned cats under field conditions in Albania, Bulgaria, Germany and Hungary.

Methods: To be eligible for enrollment in this investigator-blinded study cats had to be at least 10 weeks-old, weigh at least 1. Read More

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http://dx.doi.org/10.1186/s13071-018-3169-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240952PMC
November 2018
8 Reads

Morphometrical and molecular evidence suggests cryptic diversity among hookworms (Nematoda: Uncinaria) that parasitize pinnipeds from the south-eastern Pacific coasts.

J Helminthol 2018 Nov 15:1-9. Epub 2018 Nov 15.

Departamento de Ciencias Biológicas,Facultad de Ciencias,Universidad Santo Tomás,Los Carrera 753,Osorno,Chile.

Hookworms of the genus Uncinaria parasitize pinniped pups in various locations worldwide. Four species have been described, two of which parasitize pinniped pups in the southern hemisphere: Uncinaria hamiltoni parasitizes Otaria flavescens and Arctocephalus australis from the South American coast, and Uncinaria sanguinis parasitizes Neophoca cinerea from the Australian coast. However, their geographical ranges and host specificity are unknown. Read More

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http://dx.doi.org/10.1017/S0022149X18000950DOI Listing
November 2018

Kato-Katz thick smears as a DNA source of soil-transmitted helminths.

J Helminthol 2018 Nov 15:1-4. Epub 2018 Nov 15.

Laboratório de Epidemiologia e Sistemática Molecular,Instituto Oswaldo Cruz,Fundação Oswaldo Cruz,Pavilhão Leônidas Deane,sala 308,Avenida Brasil, 4365, Manguinhos, Rio de Janeiro,Brazil.

Despite the reduction in the prevalence of soil-transmitted helminthiases in many regions of the world, morbidity rates remain high in some rural regions. The Kato-Katz technique is a simple, inexpensive and field-applicable tool commonly used for the diagnosis and worm-burden characterization of these infections. Molecular studies have revolutionized our understanding of the epidemiology and evolutionary genetics of parasites. Read More

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https://www.cambridge.org/core/product/identifier/S0022149X1
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http://dx.doi.org/10.1017/S0022149X18001013DOI Listing
November 2018
25 Reads

Baseline Mapping of Schistosomiasis and Soil Transmitted Helminthiasis in the Northern and Eastern Health Regions of Gabon, Central Africa: Recommendations for Preventive Chemotherapy.

Trop Med Infect Dis 2018 Nov 11;3(4). Epub 2018 Nov 11.

Control Program of Parasitic Diseases, Libreville BP 2434, Gabon.

In order to follow the Preventive Chemotherapy (PC) for the transmission control as recommended by WHO, Gabon initiated in 2014 the mapping of Schistosomiasis and Soil Transmitted Helminthiasis (STH). Here, we report the results of the Northern and Eastern health regions, representing a third of the land area and 12% of its total population. All nine departments of the two regions were surveyed and from each, five schools were examined with 50 schoolchildren per school. Read More

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http://dx.doi.org/10.3390/tropicalmed3040119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306699PMC
November 2018
3 Reads

Prevalence of Gastrointestinal Parasitic Infections and Assessment of Deworming Program among Cattle and Buffaloes in Gampaha District, Sri Lanka.

Biomed Res Int 2018 9;2018:3048373. Epub 2018 Oct 9.

Department of Biosystems Engineering, Faculty of Agriculture and Plantation Management, Wayamba University, Makandura, Sri Lanka.

Gastrointestinal (GI) parasitic infection is a serious issue in cattle management. The effects of GI parasites may vary with age, sex of cattle, nutritional condition, and severity of infection. Prevalence of GI parasites among cattle population in Gampaha District has not been studied and there is no published study available. Read More

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https://www.hindawi.com/journals/bmri/2018/3048373/
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http://dx.doi.org/10.1155/2018/3048373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198547PMC
February 2019
17 Reads

Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures.

Elife 2018 11 6;7. Epub 2018 Nov 6.

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, United States.

Increases in ocean temperature are associated with changes in the distribution of fish stocks, and the foraging regimes and maternal attendance patterns of marine mammals. However, it is not well understood how these changes affect offspring health and survival. The maternal attendance patterns and immunity of South American fur seals were assessed in a rookery where hookworm disease is the main cause of pup mortality. Read More

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https://elifesciences.org/articles/38432
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http://dx.doi.org/10.7554/eLife.38432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245726PMC
November 2018
27 Reads

Terror in the dirt: Sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes.

Int J Parasitol Drugs Drug Resist 2018 12 26;8(3):496-510. Epub 2018 Oct 26.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA. Electronic address:

Infection with gastrointestinal parasitic nematodes is a major cause of chronic morbidity and economic burden around the world, particularly in low-resource settings. Some parasitic nematode species, including the human-parasitic threadworm Strongyloides stercoralis and human-parasitic hookworms in the genera Ancylostoma and Necator, feature a soil-dwelling infective larval stage that seeks out hosts for infection using a variety of host-emitted sensory cues. Here, we review our current understanding of the behavioral responses of soil-dwelling infective larvae to host-emitted sensory cues, and the molecular and cellular mechanisms that mediate these responses. Read More

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https://www.researchgate.net/scientific-contributions/135143
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https://linkinghub.elsevier.com/retrieve/pii/S22113207183011
Publisher Site
http://dx.doi.org/10.1016/j.ijpddr.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287541PMC
December 2018
15 Reads

Helminth and respiratory mite lesions in Pinnipeds from Punta San Juan, Peru.

Acta Parasitol 2018 Dec;63(4):839-844

Instituto de Patología Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Isla Teja s/n, 5090000, Valdivia, Chile.

The tissues and parasites collected from Peruvian fur seals (Arctocephalus australis) and South American sea lions (Otaria byronia) found dead at Punta San Juan, Peru were examined. The respiratory mite, Orthohalarachne attenuata infected 3 out of 32 examined fur seals and 3 out of 8 examined sea lions, however caused moderate to severe lymphohistiocytic pharyngitis only in fur seals. Hookworms, Uncinaria sp, infected 6 of the 32 examined fur seals causing variable degrees of hemorrhagic and eosinophilic enteritis. Read More

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http://dx.doi.org/10.1515/ap-2018-0103DOI Listing
December 2018
1 Read

[Current status of human hookworm infection in Jiangxi Province in 2014].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Jun;30(4):446-448

Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330096, China.

Objective: To understand the status of human hookworm ( or ) infection in Jiangxi Province.

Methods: A stratified cluster random sampling was conducted based on the geographical location and economic condition in 2014. Kato-Katz's thick smear method was used for stool examinations, and filter paper cultivation was conducted for distinguishing the species of hookworms. Read More

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http://dx.doi.org/10.16250/j.32.1374.2017191DOI Listing
June 2018
6 Reads

Standardization and application of a modified RFLP-PCR methodology for analysis of polymorphisms linked to treatment resistance in Ancylostoma braziliense.

Parasit Vectors 2018 Oct 9;11(1):540. Epub 2018 Oct 9.

Departamento de Parasitologia, L4 237, Laboratório de Parasitologia Molecular, Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.

Background: Single nucleotide polymorphisms (SNPs) in codons 167, 198 and 200 of the beta-tubulin isotype 1 gene are associated with benzimidazoles resistance in many helminths. Codon 167 mutation has never been described in hookworms; however, polymorphisms in codons 198 and 200 have been described for Ancylostoma caninum and Necator americanus. These mutations have never been investigated in Ancylostoma braziliense; therefore, it is not known if they are present in this species and whether they are correlated with treatment resistance. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-018-3125-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178248PMC
October 2018
4 Reads

A community-based surveillance of gastrointestinal helminthiasis among pregnant women in Ibadan, South West Nigeria.

Niger J Clin Pract 2018 Oct;21(10):1368-1373

Department of Paediatrics, Obstetrics and Gynaecology and Medical Microbiology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.

Background: : Intestinal helminthiasis is a major public health problem in Africa. Helminthic infection in pregnant women causes loss of appetite, poor nutrient absorption, gastrointestinal impairment, iron deficiency, and iron deficiency anemia resulting in low birth weights and preterm births. The main aim of this study is to assess the prevalence of helminthic infections in pregnant women in rural and peri-urban communities of Ibadan. Read More

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http://dx.doi.org/10.4103/njcp.njcp_196_17DOI Listing
October 2018
3 Reads

infection in human and nonhuman primates in selected areas of Oromia Regional State, Ethiopia.

J Vector Borne Dis 2018 Apr-Jun;55(2):116-121

Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Ethiopia.

Background & Objectives: The transmission of schistosomiasis, caused by trematodes of the genus Schistosoma, relies on freshwater snails that act as an intermediate host while human and other mammalian act as the definitive hosts. Many non-human primates (NHPs) such as Chlorocebus aethiops (vervet) and Papio anubis (baboon) are reported to be infected with Schistosoma mansoni in Ethiopia, but the role they play in parasite maintenance and transmission is still not clear. The objective of this study was, therefore, to determine the prevalence of S. Read More

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http://www.jvbd.org/text.asp?2018/55/2/116/242558
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http://dx.doi.org/10.4103/0972-9062.242558DOI Listing
December 2018
17 Reads

The Unique Life Cycle of Strongyloides stercoralis and Implications for Public Health Action.

Trop Med Infect Dis 2018 May 25;3(2). Epub 2018 May 25.

School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD 4700, Australia.

has one of the most complex life cycles of the human-infecting nematodes. A common misconception in medical and public health professions is that in its biology is akin to other intestinal nematodes, such as the hookworms. Despite original evidence provided by medical and veterinary research about this unique helminth, many assumptions have entered the scientific literature. Read More

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http://www.mdpi.com/2414-6366/3/2/53
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http://dx.doi.org/10.3390/tropicalmed3020053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073624PMC
May 2018
6 Reads

A Survey of Intestinal Parasites of Domestic Dogs in Central Queensland.

Trop Med Infect Dis 2017 Nov 21;2(4). Epub 2017 Nov 21.

School of Health, Medical and Applied Sciences, Central Queensland University, North Rockhampton, QSD 4702, Australia.

Australia has a very high rate of dog ownership, which in some circumstances may lead to exposure to zoonotic parasitic diseases from those companion animals. Domestic dog faecal samples ( = 300) were collected from public spaces and private property in the greater Rockhampton (Central Queensland) region and tested for intestinal helminths and protozoa by direct microscopy, two flotation methods and a modified acid-fast stain for cryptosporidia. Intestinal parasites detected included hookworms (25%), complex (9%), (3%), (3%), (1%) and (1%), spp. Read More

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http://www.mdpi.com/2414-6366/2/4/60
Publisher Site
http://dx.doi.org/10.3390/tropicalmed2040060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082058PMC
November 2017
4 Reads

Contamination of selected recreational areas in Lublin Province, Eastern Poland, by eggs of Toxocara spp., Ancylostoma spp. and Trichuris spp.

Ann Agric Environ Med 2018 Sep 8;25(3):460-463. Epub 2018 Aug 8.

Department of Biological Threats of Health and Parasitology, Institute of Rural Health, Lublin, Poland.

Introduction: While using recreational areas, people take with them accompanying animals (dogs, cats). These animals are the main source and reservoir of dangerous zoonoses, including parasitoses caused by genera of nematodes, also called roundworms, Toxocara spp., Trichuris spp. Read More

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http://www.journalssystem.com/aaem/Contamination-of-selected
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http://dx.doi.org/10.26444/aaem/92252DOI Listing
September 2018
8 Reads

Development and Evaluation of a Multiplex Quantitative Real-Time Polymerase Chain Reaction for Hookworm Species in Human Stool.

Am J Trop Med Hyg 2018 Nov;99(5):1186-1193

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Australia.

Hookworm disease caused by , , and affects half a billion people worldwide. The prevalence and intensity of infection of individual hookworm species are vital for assessing morbidity and generating targeted intervention programs for their control. The present study aims to evaluate a multiplex real-time quantitative PCR (qPCR) assay to determine the prevalence and egg intensity of all three hookworm species and compare this with standard microscopy and published genus-based conventional and real-time multiplex qPCRs. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221243PMC
November 2018
3 Reads

PCR-RFLP screening of polymorphisms associated with benzimidazole resistance in Necator americanus and Ascaris lumbricoides from different geographical regions in Brazil.

PLoS Negl Trop Dis 2018 09 17;12(9):e0006766. Epub 2018 Sep 17.

Departament of Parasitology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Ascaris lumbricoides and Necator americanus are soil-transmitted parasites with global geographic distribution, and they represent some of the most common and neglected infections in the world. Periodic treatment with mass drug administration (MDA) in endemic areas is the recommended action put forth by the World Health Organization. However, MDA can cause the selection of subpopulations that possess the genetic ability to overcome the mechanism of drug action. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141064PMC
September 2018
4 Reads

Prevalence of intestinal parasitic infections and associated risk factors for hookworm infections among primary schoolchildren in rural areas of Nakhon Si Thammarat, southern Thailand.

BMC Public Health 2018 Sep 14;18(1):1118. Epub 2018 Sep 14.

Nopphitam Hospital, Nakhon Si Thammarat, Thailand.

Background: Soil-transmitted helminth (STH) infections are among the most common type of infections worldwide and are widely distributed in tropical areas. In rural areas of southern Thailand where most land is used for agriculture, children are at risk of acquiring parasites, especially STHs. Assessing the current situation regarding parasitic infection in these areas is a prerequisite for developing appropriate control measures. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
Publisher Site
http://dx.doi.org/10.1186/s12889-018-6023-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137929PMC
September 2018
26 Reads

Comparison of individual and pooled diagnostic examination strategies during the national mapping of soil-transmitted helminths and Schistosoma mansoni in Ethiopia.

PLoS Negl Trop Dis 2018 09 10;12(9):e0006723. Epub 2018 Sep 10.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: Laboratory-based studies have highlighted that pooling stool and urine samples can reduce costs and diagnostic burden without a negative impact on the ability to estimate the intensity of soil-transmitted helminth (STH, Ascaris lumbricoides, Trichuris trichiura and hookworms) and schistosome infections (Schistosoma mansoni and S. haematobium). In this study, we compare individual and pooled stool examination strategies in a programmatic setting. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147605PMC
September 2018
7 Reads

Prevalence of intestinal parasites, with emphasis on the molecular epidemiology of Giardia duodenalis and Blastocystis sp., in the Paranaguá Bay, Brazil: a community survey.

Parasit Vectors 2018 Aug 30;11(1):490. Epub 2018 Aug 30.

Parasitology Reference and Research Laboratory, National Centre for Microbiology, Ctra. Majadahonda-Pozuelo Km 2, 28220 Majadahonda, Madrid, Spain.

Background: Intestinal protozoan parasites are major contributors to the global burden of gastrointestinal disease causing significant socioeconomic consequences. Children living in resource-poor settings with restricted access to water and sanitary services are particularly at risk of these infections.

Methods: A prospective, community-based, cross-sectional survey was conducted in Paraná (southern Brazil) between May 2015 and May 2016. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-018-3054-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117969PMC
August 2018
15 Reads

Burden of intestinal helminths and associated factors three years after initiation of mass drug administration in Arbaminch Zuria district, Southern Ethiopia.

BMC Infect Dis 2018 Aug 29;18(1):435. Epub 2018 Aug 29.

Department of Public Health, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia.

Background: Epidemiological information on the burden of various parasitic infections and associated factors in different localities is indispensable to develop appropriate control and prevention measures as well as to monitor and evaluate existing programs. Hence the aim of the present study was to assess the prevalence and associated factors of intestinal helminths among school age children in Arbaminch Zuria district, Southern Ethiopia.

Methods: A community based cross-sectional study was conducted by recruiting 391 primary school age children. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-018-3330-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114701PMC
August 2018
19 Reads
2.613 Impact Factor

Prevalence of Atopy following Mass Drug Administration with Albendazole: A Study in School Children on Flores Island, Indonesia.

Int Arch Allergy Immunol 2018;177(3):192-198. Epub 2018 Aug 21.

Department of Parasitology, Leiden University Medical Center, Leiden, the Netherlands.

Background: In many rural areas of tropical countries such as Indonesia, the prevalence of soil-transmitted helminths (STH) infections remains high. At the same time, the burden of allergic disorders in such rural areas is reported to be low and inversely associated with helminth infections. To reduce the morbidity and transmission of helminth infections, the world health organization recommends preventive treatment of school children by providing mass drug administration (MDA) with albendazole. Read More

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http://dx.doi.org/10.1159/000490952DOI Listing
December 2018
4 Reads

Intestinal parasitism and nutritional status among indigenous children from the Argentinian Atlantic Forest: Determinants of enteroparasites infections in minority populations.

Acta Trop 2018 Nov 17;187:248-256. Epub 2018 Aug 17.

Department of Environmental and Global Health, University of Florida, Gainesville, FL 32610, USA; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA.

Objective: Intestinal parasitoses, especially in the less favored populations of tropical and subtropical areas, are a scourge of high impact in public health. We conducted a cross-sectional survey to investigate the prevalence of helminths and protozoa pathogens, malnutrition, and their determinants in children from indigenous Mbyá Guaraní villages of Iguazú, in the subtropical Atlantic Forest of Argentina.

Methods: Parasitological assessment was performed using a combination of flotation, sedimentation, and centrifugation techniques, as well as temporal and permanent stains. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.08.015DOI Listing
November 2018
12 Reads

Domiciliary Cockroaches as Carriers of Human Intestinal Parasites in Lagos Metropolis, Southwest Nigeria: Implications for Public Health.

J Arthropod Borne Dis 2018 Jun 13;12(2):141-151. Epub 2018 Jun 13.

Department of Zoology, University of Lagos, Akoka, Lagos, Nigeria.

Background: Domiciliary cockroaches are obnoxious pests of significant medical importance. We investigated the prevalence of human intestinal parasites in cockroaches and its attendant public health importance.

Methods: Overall, 749 cockroaches (, 509, , 240) caught by trapping from 120 households comprising 3 different housing types in Somolu, Lagos metropolis, southwest Nigeria, in 2015 were screened for human intestinal parasites using standard parasitological techniques. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091797PMC
June 2018
19 Reads

MaxEnt modeling of soil-transmitted helminth infection distributions in Thailand.

Parasitol Res 2018 Nov 17;117(11):3507-3517. Epub 2018 Aug 17.

Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Infections due to soil-transmitted helminths (STHs), i.e. Ascaris lumbricoides, Trichuris trichiura, hookworms, and Strongyloides stercoralis, are widely distributed in tropical and subtropical areas in which approximately 1. Read More

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http://link.springer.com/10.1007/s00436-018-6048-7
Publisher Site
http://dx.doi.org/10.1007/s00436-018-6048-7DOI Listing
November 2018
9 Reads

Host- and Helminth-Derived Endocannabinoids That Have Effects on Host Immunity Are Generated during Infection.

Infect Immun 2018 11 25;86(11). Epub 2018 Oct 25.

Division of Biomedical Sciences, University of California, Riverside, Riverside, California, USA

Helminths have coevolved with their hosts, resulting in the development of specialized host immune mechanisms and parasite-specific regulatory products. Identification of new pathways that regulate helminth infection could provide a better understanding of host-helminth interaction and may identify new therapeutic targets for helminth infection. Here we identify the endocannabinoid system as a new mechanism that influences host immunity to helminths. Read More

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http://dx.doi.org/10.1128/IAI.00441-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204704PMC
November 2018
4 Reads

Soil-transmitted helminth infections, anemia and undernutrition among schoolchildren in Yirgacheffee, South Ethiopia.

BMC Res Notes 2018 Aug 13;11(1):585. Epub 2018 Aug 13.

Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia.

Objective: Current data on soil-transmitted helminth infections, anemia and malnutrition that are largely neglected is vital to the control and management of them in a specific setting. This study was, therefore, aimed at determining the status of the three health concerns in one of the high-risk groups, schoolchildren, in South Ethiopia.

Results: Among the 443 sampled schoolchildren, 54% were infected with soil-transmitted helminths (STHs) and 15. Read More

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http://dx.doi.org/10.1186/s13104-018-3679-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090612PMC
August 2018
1 Read

Dynamic changes in human-gut microbiome in relation to a placebo-controlled anthelminthic trial in Indonesia.

PLoS Negl Trop Dis 2018 08 9;12(8):e0006620. Epub 2018 Aug 9.

Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands.

Background: Microbiome studies suggest the presence of an interaction between the human gut microbiome and soil-transmitted helminth. Upon deworming, a complex interaction between the anthelminthic drug, helminths and microbiome composition might occur. To dissect this, we analyse the changes that take place in the gut bacteria profiles in samples from a double blind placebo controlled trial conducted in an area endemic for soil transmitted helminths in Indonesia. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084808PMC
August 2018
13 Reads