3,208 results match your criteria Hookworms


Semi-domesticated dogs as a potential reservoir for zoonotic hookworms in Bangkok, Thailand.

Vet World 2020 May 16;13(5):909-915. Epub 2020 May 16.

Center for Agricultural Biotechnology, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, Thailand.

Background And Aim: Hookworms are parasitic nematodes that live in the small intestine of their mammalian hosts including humans, dogs, and cats. This study was conducted to determine the prevalence and perform genetic characterization of hookworms using molecular techniques and to elucidate the risk factors associated with hookworm infections among semi-domesticated dogs residing in temples in the Bangkok Metropolitan Area, Thailand.

Materials And Methods: A total of 500 fecal samples were collected from semi-domesticated dogs from 91 temples in 48 districts of Bangkok. Read More

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http://dx.doi.org/10.14202/vetworld.2020.909-915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311867PMC

Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR.

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0008296. Epub 2020 Jul 2.

Department of Virology, Parasitology and Immunology, Ghent University, Merelbeke, Belgium.

World Health Organization (WHO) has defined moderate-to-heavy intensity (M&HI) infections with soil-transmitted helminths (Ascaris lumbricoides, Trichuris trichiura and the two hookworms, Ancylostoma duodenale and Necator americanus) based on specific values of eggs per gram of stool, as measured by the Kato-Katz method. There are a variety of novel microscopy and DNA-based methods but it remains unclear whether applying current WHO thresholds on to these methods allows for a reliable classification of M&HI infections. We evaluated both WHO and method-specific thresholds for classifying the M&HI infections for novel microscopic (FECPAKG2, McMaster and Mini-FLOTAC) and DNA-based (qPCR) diagnostic methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008296DOI Listing

Diagnostic sensitivity of direct wet mount microscopy for soil-transmitted helminth infections in Jimma Town, Ethiopia.

J Infect Dev Ctries 2020 Jun 29;14(6.1):66S-71S. Epub 2020 Jun 29.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Introduction: Soil-transmitted helminthiasis (STH) remains a major public health problem in school children in Ethiopia. Although direct wet mount microscopy (DWMM) is the means to diagnose parasitic diseases in health care facilities in Ethiopia, it remains unclear what its diagnostic performance is for STH.

Methodology: A cross-sectional study was performed in Jimma Town (Ethiopia) and included 600 children from 10 primary schools. Read More

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http://dx.doi.org/10.3855/jidc.11733DOI Listing

Anaemia in asymptomatic parasite carriers living in urban, rural and peri-urban settings of Gabon.

Trans R Soc Trop Med Hyg 2020 Jul 1. Epub 2020 Jul 1.

Département de Parasitologie-Mycologie-Médecine Tropicale, Faculté de Médecine, Université des Sciences de la Santé, BP 4009, Libreville, Gabon.

Background: This cross-sectional study was carried out in different settlements of Gabon to determine the influence of single or multiple parasite carriage on haemoglobin (Hb) levels.

Methods: Between April 2015 and June 2016, healthy volunteers from urban, peri-urban and rural areas were screened for malaria, blood filariasis and intestinal parasitic infections using microscopic methods. Hb concentration was measured with a Hemocue analyser. Read More

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http://dx.doi.org/10.1093/trstmh/traa047DOI Listing

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes.

Molecules 2020 Jun 27;25(13). Epub 2020 Jun 27.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Soil-transmitted nematodes (STN) infect 1-2 billion of the poorest people worldwide. Only benzimidazoles are currently used in mass drug administration, with many instances of reduced activity. Terpenes are a class of compounds with anthelmintic activity. Read More

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http://dx.doi.org/10.3390/molecules25132958DOI Listing

Environmental Contamination by Dog Feces in Touristic Areas of Italy: Parasitological Aspects and Zoonotic Hazards.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Laboratorio di Parassitologia - Ospedale Didattico Veterinario, Dipartimento di Medicina Veterinaria, Università degli Studi di Sassari, Sassari, Italy.

Public spaces are common sites of fecal contamination which is concerning considering the prevalence rates of gastrointestinal pathogens carried by pets. Multiple pet-bound parasite species capable of infecting humans have previously been reported in fecal samples collected from urban areas around the globe, including Italy In addition, the presence of gastrointestinal parasites has recently been shown in pets from the island of Sardinia, a well-known touristic destination. For these reasons, this study aims to evaluate the level of fecal contamination of two of the most important cities on Sardinia. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0169DOI Listing

Distribution of Parasitic Helminths in the Small Intestine of the Red Fox ().

Pathogens 2020 Jun 16;9(6). Epub 2020 Jun 16.

Department of Parasitology and Invasive Diseases, National Veterinary Research Institute, Partyzantów Avenue 57, 24-100 Puławy, Poland.

The aim of the study was to analyze the distribution of the main groups of parasitic helminths within the small intestine of the red fox on the example of animals coming from eastern Poland. Two hundred and sixteen red foxes shot in eastern Poland were used in the investigation. Before examination, each small intestine was divided into three equal parts: anterior (A), middle (M), and posterior (P). Read More

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http://dx.doi.org/10.3390/pathogens9060477DOI Listing

High-throughput multiplex qPCRs for the surveillance of zoonotic species of canine hookworms.

PLoS Negl Trop Dis 2020 Jun 15;14(6):e0008392. Epub 2020 Jun 15.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.

The canine hookworms Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma caninum and Uncinaria stenocephala are not only capable of producing morbidity and mortality in dogs but are also neglected tropical zoonoses. Each hookworm species differs considerably in its geographical distribution, life cycle, biology, pathogenic impacts on both canine and human hosts, zoonotic potential, and response to treatment with anthelminthics. Here we describe the development and validation of two Taq-Man based multiplex PCR assays capable of detecting and differentiating all four canine hookworm species in faeces of naturally infected dogs. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316352PMC

Preliminary Study on the Prevalence of Endoparasite Infections and Vector-borne Diseases in Outdoor Dogs in Bulgaria.

Helminthologia 2020 Jun 23;57(2):171-178. Epub 2020 May 23.

Department of Veterinary Microbiology, Infectious and Parasitic diseases, Faculty of Veterinary Medicine, Trakia University, 6000 Stara Zagora, Bulgaria.

The present work was designed to evaluate the prevalence of gastrointestinal parasites and some vector-borne pathogens in dogs in Bulgaria. A total of 172 owned dogs, keeping outside, were included in the study. Fecal samples were examined using standard flotation and sedimentation methods. Read More

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http://dx.doi.org/10.2478/helm-2020-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261023PMC

Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas.

PLoS Negl Trop Dis 2020 Jun 9;14(6):e0008378. Epub 2020 Jun 9.

Departamento de Ciências Agrárias e Ambientais, Programa de Pós-Graduação em Ciência Animal, Universidade Estadual de Santa Cruz-UESC, Ilhéus, Bahia, Brasil.

The aim of this study was to determine the prevalence and risk factors of the main enteric parasitic infections that affect children and dogs in the municipality of Ilhéus, Bahia, Brazil; and to identify the geopolitical areas that should receive priority interventions to combat them. Between March and November 2016, fecal samples of 143 dogs and 193 children aged 1 month to 5 years were collected in 40 rural and semirural communities using a systematic sampling approach, stratified by district. Samples were collected by legal guardians of the children and / or dog owners. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282628PMC

Host Population Expansion and the Genetic Architecture of the Pinniped Hookworm Uncinaria lucasi.

J Parasitol 2020 Jun;106(3):383-391

Department of Entomology and Nematology, University of California Davis, Davis, California 95616.

The long-term fidelity of pinniped hosts to their natal rookery site suggests the genetic architecture of their Uncinaria spp. hookworms should be strongly structured by host breeding biology. However, historical events affecting host populations may also shape parasite genetic structure. Read More

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http://dx.doi.org/10.1645/19-172DOI Listing

Detection of gastrointestinal parasitism at recreational canine sites in the USA: the DOGPARCS study.

Parasit Vectors 2020 Jun 1;13(1):275. Epub 2020 Jun 1.

Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.

Background: The rapid growth in off-leash dog parks provides opportunity for canine socialization activities but carries risk of exposure to intestinal parasites. This study assessed the prevalence of these infections in dogs visiting off-leash dog parks.

Methods: Fresh defecations were collected from dogs visiting parks in 30 metropolitan areas across the USA. Read More

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http://dx.doi.org/10.1186/s13071-020-04147-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268625PMC

Combined use of chemical and biological compounds to control hookworm.

J Helminthol 2020 Jun 1;94:e160. Epub 2020 Jun 1.

Pharmaceutical Science Graduate Program, Universidade Vila Velha - UVV, Minas Gerais, Brazil.

The aim of this study was to evaluate the combined use of different chemical (albendazole, ivermectin, glycerine and Vaseline) and biological (Monacrosporium thaumasium) compounds in the control of Ancylostoma caninum. Infective larvae of A. caninum were obtained from coprocultures of positive faeces from naturally infected dogs. Read More

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http://dx.doi.org/10.1017/S0022149X20000334DOI Listing

Opportunistic Mapping of and Hookworm in Dogs in Remote Australian Communities.

Pathogens 2020 May 21;9(5). Epub 2020 May 21.

Faculty of Science and Engineering, Flinders University, Bedford Park, SA 5042, Australia.

Both S and hookworms are common soil-transmitted helminths in remote Australian communities. In addition to infecting humans, and some species of hookworms infect canids and therefore present both environmental and zoonotic sources of transmission to humans. Currently, there is limited information available on the prevalence of hookworms and infections in dogs living in communities across the Northern Territory in Australia. Read More

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http://dx.doi.org/10.3390/pathogens9050398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281600PMC

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms.

PLoS Negl Trop Dis 2020 05 26;14(5):e0008237. Epub 2020 May 26.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. americanus live in the small intestine of the human host where they inject excretory/secretory (ES) products into the mucosa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274458PMC

Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities.

PLoS Pathog 2020 May 14;16(5):e1008508. Epub 2020 May 14.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia.

Parasitic helminths have coevolved with humans over millennia, intricately refining and developing an array of mechanisms to suppress or skew the host's immune system, thereby promoting their long-term survival. Some helminths, such as hookworms, cause little to no overt pathology when present in modest numbers and may even confer benefits to their human host. To exploit this evolutionary phenomenon, clinical trials of human helminth infection have been established and assessed for safety and efficacy for a range of immune dysfunction diseases and have yielded mixed outcomes. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224462PMC

Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs.

Int J Parasitol Drugs Drug Resist 2020 Apr 20;13:22-27. Epub 2020 Apr 20.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.

Ancylostoma caninum is the most prevalent intestinal nematode of dogs, and has a zoonotic potential. Multiple-drug resistance (MDR) has been confirmed in a number of A. caninum isolates, including isolate Worthy 4. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214830PMC

Comparison of multi-parallel qPCR and double-slide Kato-Katz for detection of soil-transmitted helminth infection among children in rural Bangladesh.

PLoS Negl Trop Dis 2020 04 24;14(4):e0008087. Epub 2020 Apr 24.

Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, California, United States of America.

There is growing interest in local elimination of soil-transmitted helminth (STH) infection in endemic settings. In such settings, highly sensitive diagnostics are needed to detect STH infection. We compared double-slide Kato-Katz, the most commonly used copromicroscopic detection method, to multi-parallel quantitative polymerase chain reaction (qPCR) in 2,799 stool samples from children aged 2-12 years in a setting in rural Bangladesh with predominantly low STH infection intensity. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202662PMC

The Strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review.

PLoS Negl Trop Dis 2020 04 13;14(4):e0008184. Epub 2020 Apr 13.

Universidad Nacional de Salta, Instituto de Investigaciones de Enfermedades Tropicales/CONICET, Orán, Salta, Argentina.

Trial Registration: PROSPERO (registration code CRD42019131127). Read More

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http://dx.doi.org/10.1371/journal.pntd.0008184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188296PMC

Prevalence of Intestinal Parasitic Infections and Associated Risk Factors among the First-Cycle Primary Schoolchildren in Sasiga District, Southwest Ethiopia.

J Parasitol Res 2020 13;2020:8681247. Epub 2020 Mar 13.

ONRS, Sasiga District Education Office, Ethiopia.

Intestinal parasitic infections (IPIs) have been major public health burdens in low-income countries like Ethiopia. Studies in different areas of Ethiopia have shown a high prevalence of IPIs in poor families. A similar study has not been conducted in Sasiga District given that the area is possibly at high-risk of IPIs due to the prevailing risk factors. Read More

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http://dx.doi.org/10.1155/2020/8681247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093910PMC

Soil-transmitted helminths and schistosomiasis among pre-school age children in a rural setting of Busia County, Western Kenya: a cross-sectional study of prevalence, and associated exposures.

BMC Public Health 2020 Mar 18;20(1):356. Epub 2020 Mar 18.

Eastern & Southern Africa Centre of International Parasite Control (ESACIPAC), Kenya Medical Research Institute (KEMRI), Mbangathi road, P.O.Box 54840-00200, Nairobi, Kenya.

Background: Soil-transmitted helminths (STH) and schistosomiasis continue to cause serious health problems among affected communities. To ensure that infection transmission levels are reduced, repeated mass drug administration at regular intervals has been recommended by World Health Organization. Pre-school age children (PSAC) have been neglected both in terms of research activities and in control programmes in the past for reasons that they carry insignificant infection levels. Read More

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http://dx.doi.org/10.1186/s12889-020-08485-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079432PMC

[Investigation on human hookworm infections in Anhui Province from 2014 to 2015].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2020 Jan;32(1):87-90

Anhui Provincial Institute of Parasitic Diseases, Hefei 230061, China.

Objective: To understand the current status and changing tendency of human hookworm infections in Anhui Province.

Methods: According to the unified national survey scheme, a total of 48 survey sites were sampled from 16 counties (cities) in 4 ecological regions of Anhui Province using a stratified cluster random sampling method from 2014 to 2015. The hookworm eggs were detected in the fecal samples from permanent residents at ages of over one year living in the survey sites using a modified Kato-Katz thick smear method, and the subjects'health knowledge and behaviors were investigated using questionnaire survey. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019242DOI Listing
January 2020

Parasite associations predict infection risk: incorporating co-infections in predictive models for neglected tropical diseases.

Parasit Vectors 2020 Mar 16;13(1):138. Epub 2020 Mar 16.

Malaria and Other Parasitic Diseases Division, Rwanda Biomedical Center, Ministry of Health, Kigali, Rwanda.

Background: Schistosomiasis and infection by soil-transmitted helminths are some of the world's most prevalent neglected tropical diseases. Infection by more than one parasite (co-infection) is common and can contribute to clinical morbidity in children. Geostatistical analyses of parasite infection data are key for developing mass drug administration strategies, yet most methods ignore co-infections when estimating risk. Read More

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http://dx.doi.org/10.1186/s13071-020-04016-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077138PMC

Twenty-five-year research progress in hookworm excretory/secretory products.

Parasit Vectors 2020 Mar 14;13(1):136. Epub 2020 Mar 14.

Guangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.

Hookworm infection is a major public health problem that threatens about 500 million people throughout tropical areas of the world. Adult hookworms survive for many years in the host intestine, where they suck blood, causing iron deficiency anemia and malnutrition. Numerous molecules, named excretory/secretory (ES) products, are secreted by hookworm adults and/or larvae to aid in parasite survival and pathobiology. Read More

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http://dx.doi.org/10.1186/s13071-020-04010-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071665PMC

Efficacy of Simparica Trio™, a novel chewable tablet containing sarolaner, moxidectin and pyrantel, against induced hookworm infections in dogs.

Parasit Vectors 2020 Mar 1;13(1):99. Epub 2020 Mar 1.

Zoetis, Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI, 49007, USA.

Background: Ancylostomatids ('hookworms') are among the most important zoonotic nematode parasites infecting dogs worldwide. Ancylostoma caninum and Uncinaria stenocephala are two of the most common hookworm species that infect dogs. Both immature and adult stages of hookworms are voracious blood feeders and can cause death in young dogs before infection can be detected by routine fecal examination. Read More

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http://dx.doi.org/10.1186/s13071-020-3951-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049382PMC

Field efficacy and safety of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against naturally acquired gastrointestinal nematode infections in dogs presented as veterinary patients in Europe and the USA.

Parasit Vectors 2020 Mar 1;13(1):70. Epub 2020 Mar 1.

Department of Parasitology and Zoology, University of Veterinary Medicine, István u. 2, 1078, Budapest, Hungary.

Background: Gastrointestinal nematodes are parasites that commonly infect dogs, and infections can be subclinical or may cause considerable clinical disease. Some species are zoonotic and may also cause clinical disease in humans. Year-round treatment of dogs is recommended to eliminate existing infections, which also indirectly reduces the potential for subsequent human exposure to zoonotic species. Read More

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http://dx.doi.org/10.1186/s13071-020-3947-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049394PMC

Egg genotyping reveals the possibility of patent Ancylostoma caninum infection in human intestine.

Sci Rep 2020 Feb 20;10(1):3006. Epub 2020 Feb 20.

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Departamento de Parasitologia, L4 237, Laboratório de Parasitologia Molecular, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Hookworms are intestinal parasites that cause major public health problems, especially in developing countries. To differentiate eggs from different hookworm species, it is necessary to use molecular methodologies, since the eggs are morphologically similar. Here, we performed the molecular identification of single hookworm eggs from six Brazilian states. Read More

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http://dx.doi.org/10.1038/s41598-020-59874-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033205PMC
February 2020

Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps.

Cell Host Microbe 2020 02;27(2):277-289.e6

Laboratory of Intestinal Immunology, Department of Immunology and Pathology, Monash University, Melbourne, VIC 3004, Australia. Electronic address:

Hookworms cause a major neglected tropical disease, occurring after larvae penetrate the host skin. Neutrophils are phagocytes that kill large pathogens by releasing neutrophil extracellular traps (NETs), but whether they target hookworms during skin infection is unknown. Using a murine hookworm, Nippostrongylus brasiliensis, we observed neutrophils being rapidly recruited and deploying NETs around skin-penetrating larvae. Read More

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http://dx.doi.org/10.1016/j.chom.2020.01.011DOI Listing
February 2020

The NET Effect of Neutrophils during Helminth Infection.

Cell Host Microbe 2020 02;27(2):165-168

Center for Immunity and Inflammation and Department of Medicine, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ 07103, USA. Electronic address:

Recent studies show that neutrophils mediate both tissue damage and host protection in response to multicellular parasites. In this issue of Cell Host & Microbe, Bouchery et al. demonstrate the importance of neutrophil extracellular traps in helminth damage after primary infections. Read More

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http://dx.doi.org/10.1016/j.chom.2020.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196278PMC
February 2020
12.328 Impact Factor

Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection.

PLoS Negl Trop Dis 2020 02 13;14(2):e0008057. Epub 2020 Feb 13.

National School of Tropical Medicine, Departments of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, United States of America.

Background: Ascaris lumbricoides is one of the three major soil-transmitted gastrointestinal helminths (STHs) that infect more than 440 million people in the world, ranking this neglected tropical disease among the most common afflictions of people living in poverty. Children infected with this roundworm suffer from malnutrition, growth stunting as well as cognitive and intellectual deficits. An effective vaccine is urgently needed to complement anthelmintic deworming as a better approach to control helminth infections. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017989PMC
February 2020

Molecular characterization and tissue localization of glutathione -transferase from adult .

J Helminthol 2020 Jan 21;94:e118. Epub 2020 Jan 21.

Guangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou510642, China.

Glutathione S-transferases (GSTs) are a detoxifying enzyme family that is essential for parasite blood-feeding and survival, and represent potential targets for hookworm vaccine development. Multiple GST-encoding complementary DNAs (cDNAs) have been cloned from Ancylostoma caninum and Necator americanus, but there are no reports about the cloning of this enzyme from Ancylostoma ceylanicum, the animal-derived zoonotic hookworm. To study the molecular nature and tissue localization of GST of A. Read More

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http://dx.doi.org/10.1017/S0022149X20000012DOI Listing
January 2020

Prevalence of contamination by intestinal parasites in vegetables (Lactuca sativa L. and Coriandrum sativum L.) sold in markets in Belém, northern Brazil.

J Sci Food Agric 2020 May 3;100(7):2859-2865. Epub 2020 Mar 3.

Department of Biomedicine, Centro Universitário Metropolitano da Amazônia, Belém, Brazil.

Background: Previous studies have recorded a high prevalence of intestinal parasites in lettuce (Lactuca sativa L.) and coriander (Coriandrum sativum L.) destined for human consumption. Read More

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http://dx.doi.org/10.1002/jsfa.10265DOI Listing

Insights into hookworm prevalence in Asia: a systematic review and meta-analysis.

Trans R Soc Trop Med Hyg 2020 Feb;114(3):141-154

Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Introduction: Hookworm infections are neglected tropical diseases of humans and animals worldwide. A meta-analysis and systematic review was designed to evaluate the prevalence of hookworm infection in animal and human hosts in Asia until July 2018.

Methods: The available online articles of five English databases (PubMed, Scopus, Science Direct, Web of Science and Google Scholar) were explored. Read More

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http://dx.doi.org/10.1093/trstmh/trz115DOI Listing
February 2020
1.931 Impact Factor

Prevalence and Intensity of Soil-Transmitted Helminth Infection among Rural Community of Southwest Ethiopia: A Community-Based Study.

Biomed Res Int 2019 14;2019:3687873. Epub 2019 Dec 14.

Institute of Health, School of Medical Laboratory Sciences, Jimma University, Jimma, Ethiopia.

Background: Helminths are significant contributors to global health problems. Subgroup soil-transmitted helminths are among the listed neglected tropical diseases. The rural inhabitants often suffer from heavy infection, particularly children and pregnant women. Read More

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http://dx.doi.org/10.1155/2019/3687873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931019PMC

What does soil-transmitted helminth elimination look like? Results from a targeted molecular detection survey in Japan.

Parasit Vectors 2020 Jan 8;13(1). Epub 2020 Jan 8.

Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.

Background: Japan is one of the few countries believed to have eliminated soil-transmitted helminths (STHs). In 1949, the national prevalence of Ascaris lumbricoides was 62.9%, which decreased to 0. Read More

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http://dx.doi.org/10.1186/s13071-019-3875-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950881PMC
January 2020

Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines.

Parasitol Int 2020 Apr 3;75:102051. Epub 2020 Jan 3.

Department of Parasitology and Tropical Medicine, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

Helminth diseases are the ancient scourges of humans and their damages are 'silent and insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great impact. This review covers information regarding vaccine candidates against schistosomiasis and hookworms that reached at least up to the phase-1 trial and literatures regarding other vaccine candidates have been excluded. Read More

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http://dx.doi.org/10.1016/j.parint.2020.102051DOI Listing

Soil-Transmitted Helminth infections reduction in Bhutan: A report of 29 years of deworming.

PLoS One 2020 3;15(1):e0227273. Epub 2020 Jan 3.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Soil Transmitted Helminth (STH) infections affect over 1.5 billion people worldwide. Although prevalent in all age groups, school aged children are a high-risk groups for STH infections. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227273PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941809PMC

Safety and tolerability of experimental hookworm infection in humans with metabolic disease: study protocol for a phase 1b randomised controlled clinical trial.

BMC Endocr Disord 2019 Dec 11;19(1):136. Epub 2019 Dec 11.

Centre for Chronic Disease Prevention, Australian Institute of Tropical Health & Medicine, James Cook University, QLD, Cairns, Australia.

Background: Abdominal obesity and presence of the metabolic syndrome (MetS) significantly increase the risk of developing diseases such as Type 2 diabetes mellitus (T2DM) with escalating emergence of MetS and T2DM constituting a significant public health crisis worldwide. Lower prevalence of inflammatory and metabolic diseases such as T2DM in countries with higher incidences of helminth infections suggested a potential role for these parasites in the prevention and management of certain diseases. Recent studies confirmed the potential protective nature of helminth infection against MetS and T2DM via immunomodulation or, potentially, alteration of the intestinal microbiota. Read More

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http://dx.doi.org/10.1186/s12902-019-0461-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907345PMC
December 2019

Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat?

Parasit Vectors 2019 Dec 9;12(1):576. Epub 2019 Dec 9.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.

Background: The canine hookworm, Ancylostoma caninum is the most prevalent and important intestinal nematode parasite of dogs in the USA. Hookworms are typically well controlled by treatment with all commonly used anthelmintics that are approved for this use in dogs. However, in the past few years, cases of recurrent/persistent canine hookworm infections appear to have dramatically increased, suggesting that anthelmintic resistance (AR) may have evolved in this parasite. Read More

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http://dx.doi.org/10.1186/s13071-019-3828-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902405PMC
December 2019

A New Species of (Nemata: Strongylida: Ancylostomatidae) from Two Species of in Lowland Bolivia.

J Parasitol 2019 12;105(6):904-912

Harold W. Manter Laboratory of Parasitology, W-529 Nebraska Hall, University of Nebraska State Museum, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0514.

From the small intestines of both and collected from August 1984 through June 1990 from the eastern lowlands of the Department of Santa Cruz, Bolivia a total of 36 specimens of were recovered. Morphological investigation and comparisons with known species described and reported from mammals in the Neotropical Region show that this is an undescribed species, herein described as new. These nematans were collected from individuals of collected from near a locality called Caranda (northwest of Santa Cruz de la Sierra) and from from near Santa Rosa de la Roca (northeast of Santa Cruz de la Sierra) and from cajuchis collected from 3 km west of Estación El Pailón, 30 km east of Santa Cruz de la Sierra. Read More

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December 2019

Canine gastrointestinal nematode transmission potential in municipal dog parks in the southeast United States.

Vet Parasitol Reg Stud Reports 2019 12 3;18:100324. Epub 2019 Aug 3.

University of Georgia, College of Veterinary Medicine, Athens, GA, USA. Electronic address:

Monthly canine parasite prophylactic products prevent not only adult heartworm infection, but also patent infections with specific gastrointestinal parasites. While most monthly products control and treat certain hookworm and roundworm infections, fewer are labeled for whipworm (Trichuris vulpis). Therefore, we hypothesized that fecal samples collected from municipal dog parks will have a greater prevalence of whipworm eggs compared to hookworm and roundworm eggs. Read More

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http://dx.doi.org/10.1016/j.vprsr.2019.100324DOI Listing
December 2019

Gastrointestinal parasites in shelter cats of central Italy.

Vet Parasitol Reg Stud Reports 2019 12 23;18:100321. Epub 2019 Jul 23.

Dipartimento di Scienze Veterinarie, Università di Pisa, Viale delle Piagge 2, 56124 Pisa, Italy. Electronic address:

In Italy, the limited resources and the large number of cats living in feline shelters may facilitate the spread of parasite infections that may affect the health of cats and expose shelter workers and adoptive owners to zoonosis. Prevalence and risk factors of potential zoonotic and host-specific gastrointestinal parasite infections were assessed in cats living in public and private shelters of central Italy. Individual fecal samples were examined macroscopically and then screened microscopically by fresh and Lugol stained fecal smears and by flotation and the Baermann tests. Read More

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http://dx.doi.org/10.1016/j.vprsr.2019.100321DOI Listing
December 2019

Efficacy of single topical treatment of Selamectin (Revolution®) against Ancylostoma ceylanicum in experimentally infected cats.

Vet Parasitol Reg Stud Reports 2019 12 31;18:100346. Epub 2019 Oct 31.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria 3010, Australia.

Ancylostoma ceylanicum, a species of hookworm, is a common parasite of dogs and cats in the Asia-Pacific region. The objective of this study was to determine the efficacy of a single topical treatment of selamectin (Revolution®) against A. ceylanicum in experimentally infected cats. Read More

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http://dx.doi.org/10.1016/j.vprsr.2019.100346DOI Listing
December 2019

Soil contamination of a public park by human and canine mastadenovirus, as well as hookworms and Toxocara spp eggs.

Rev Inst Med Trop Sao Paulo 2019 25;61:e60. Epub 2019 Nov 25.

Universidade Feevale, Instituto de Ciências da Saúde, Laboratório de Microbiologia Molecular, Novo Hamburgo, Rio Grande do Sul, Brazil.

Public parks are leisure environments widely used by both, adults and children, often accompained by their pets. Soil contamination of these environments by enteric viruses and intestinal parasites occurs through these animals feces. The aim of this work was to detect Carnivore protoparvovirus 1 (CPV-1) and different species of Mastadenovirus in soils samples from a park located in a medium-sized city in Brazil and evaluate the presence of helminth eggs and larvae in 18 points of a public park soil samples, as well as feces found on this site during six months. Read More

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http://dx.doi.org/10.1590/S1678-9946201961060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880976PMC
December 2019
0.907 Impact Factor

Domains of transmission and association of community, school, and household sanitation with soil-transmitted helminth infections among children in coastal Kenya.

PLoS Negl Trop Dis 2019 11 25;13(11):e0007488. Epub 2019 Nov 25.

Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute, Nairobi, Kenya.

Introduction: Few studies have simultaneously examined the role of sanitation conditions at the home, school, and community on soil-transmitted helminth (STH) infection. We examined the contribution of each domain that children inhabit (home, village, and school) to STH infection and estimated the association of STH infection with sanitation in each domain.

Methods: Using data from 4,104 children from Kwale County, Kenya, who reported attending school, we used logistic regression models with cross-classified random effects to calculate measures of general contextual effects and estimate associations of village sanitation coverage (percentage of households with reported access to sanitation), school sanitation coverage (number of usable toilets per enrolled pupil), and sanitation access at home with STH infection. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901232PMC
November 2019

Prediction of hookworm prevalence in southern India using environmental parameters derived from Landsat 8 remotely sensed data.

Int J Parasitol 2020 01 20;50(1):47-54. Epub 2019 Nov 20.

Division of Gastrointestinal Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

Soil-transmitted helminth infections propagate poverty and slow economic growth in low-income countries. As with many other neglected tropical diseases, environmental conditions are important determinants of soil-transmitted helminth transmission. Hence, remotely sensed data are commonly utilised in spatial risk models intended to inform control strategies. Read More

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http://dx.doi.org/10.1016/j.ijpara.2019.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981258PMC
January 2020

Host factors associated with Giardia duodenalis infection in dogs across multiple diagnostic tests.

Parasit Vectors 2019 Nov 21;12(1):556. Epub 2019 Nov 21.

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: The aim of this study was to assess potential associations between Giardia duodenalis infection in dogs, as determined by three diagnostic tests, and dog's group of origin, fecal consistency, age, sex, neuter status, and co-infections with other gastrointestinal parasites.

Methods: Fecal samples from 1291 dogs from four groups (household, shelter, hunting and clinical dogs) were tested with qPCR, rapid enzyme immunochromatographic assay (IDEXX SNAP Giardia), and direct immunofluorescence (DFA, Merifluor) for presence of G. duodenalis. Read More

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http://dx.doi.org/10.1186/s13071-019-3810-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873540PMC
November 2019

Gastrointestinal parasites of arctic foxes (Vulpes lagopus) and sibling voles (Microtus levis) in Spitsbergen, Svalbard.

Parasitol Res 2019 Dec 15;118(12):3409-3418. Epub 2019 Nov 15.

Centre for Polar Ecology, Faculty of Science, University of South Bohemia in České Budějovice, Branišovská 1760, 370 05, České Budějovice, Czech Republic.

The arctic fox (Vulpes lagopus), an apex predator with an omnipresent distribution in the Arctic, is a potential source of intestinal parasites that may endanger people and pet animals such as dogs, thus posing a health risk. Non-invasive methods, such as coprology, are often the only option when studying wildlife parasitic fauna. However, the detection and identification of parasites are significantly enhanced when used in combination with methods of molecular biology. Read More

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http://dx.doi.org/10.1007/s00436-019-06502-8DOI Listing
December 2019

Soil-Transmitted Helminths And Other Intestinal Parasites Among Schoolchildren In Southern Ethiopia.

Res Rep Trop Med 2019 24;10:137-143. Epub 2019 Oct 24.

Department of Biology, Hawassa University College of Natural and Computational Sciences, Hawassa, Ethiopia.

Background: Intestinal parasitic infections are the neglected tropical diseases that have a devastating effect and leads to malnutrition, morbidity and mortality in schoolchildren. The aim of this study was to determine the presence of soil-transmitted and other intestinal parasites among schoolchildren in southern Ethiopia.

Methods: A cross-sectional study was conducted in Gara Riketa primary school children at Hawassa Tula Sub-City, Southern Ethiopia from March 1 to April 20, 2017. Read More

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http://dx.doi.org/10.2147/RRTM.S210200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817342PMC
October 2019