6,367 results match your criteria Hookworm


A randomized controlled trial to investigate safety and variability of egg excretion after repeated controlled human hookworm infection.

J Infect Dis 2020 Jul 10. Epub 2020 Jul 10.

Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands.

Background: Controlled human hookworm infections could significantly contribute to the development of a hookworm vaccine. However, current models are hampered by low and unstable egg output, reducing generalizability and increasing sample sizes. This study aims to investigate the safety, tolerability and egg output of repeated exposure to hookworm larvae. Read More

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http://dx.doi.org/10.1093/infdis/jiaa414DOI Listing

Semi-domesticated dogs as a potential reservoir for zoonotic hookworms in Bangkok, Thailand.

Vet World 2020 May 16;13(5):909-915. Epub 2020 May 16.

Center for Agricultural Biotechnology, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom, Thailand.

Background And Aim: Hookworms are parasitic nematodes that live in the small intestine of their mammalian hosts including humans, dogs, and cats. This study was conducted to determine the prevalence and perform genetic characterization of hookworms using molecular techniques and to elucidate the risk factors associated with hookworm infections among semi-domesticated dogs residing in temples in the Bangkok Metropolitan Area, Thailand.

Materials And Methods: A total of 500 fecal samples were collected from semi-domesticated dogs from 91 temples in 48 districts of Bangkok. Read More

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http://dx.doi.org/10.14202/vetworld.2020.909-915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311867PMC

Diagnostic sensitivity of direct wet mount microscopy for soil-transmitted helminth infections in Jimma Town, Ethiopia.

J Infect Dev Ctries 2020 Jun 29;14(6.1):66S-71S. Epub 2020 Jun 29.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Introduction: Soil-transmitted helminthiasis (STH) remains a major public health problem in school children in Ethiopia. Although direct wet mount microscopy (DWMM) is the means to diagnose parasitic diseases in health care facilities in Ethiopia, it remains unclear what its diagnostic performance is for STH.

Methodology: A cross-sectional study was performed in Jimma Town (Ethiopia) and included 600 children from 10 primary schools. Read More

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http://dx.doi.org/10.3855/jidc.11733DOI Listing

Trends and seasonal patterns in intestinal parasites diagnosed in primary health facilities in Northwest Ethiopia.

J Infect Dev Ctries 2020 Jun 29;14(6.1):58S-65S. Epub 2020 Jun 29.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Introduction: Intestinal parasites have an insidious impact on human health. In response to high parasite frequencies in Northwest Ethiopia, mass drug administration (MDA) is provided for school children using albendazole/mebendazole (since 2007) and praziquantel (since 2015). The study objective was to assess trends and seasonal patterns of intestinal parasite infections in a context of MDA. Read More

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http://dx.doi.org/10.3855/jidc.11729DOI Listing

Anthelmintic Activity of Yeast Particle-Encapsulated Terpenes.

Molecules 2020 Jun 27;25(13). Epub 2020 Jun 27.

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Soil-transmitted nematodes (STN) infect 1-2 billion of the poorest people worldwide. Only benzimidazoles are currently used in mass drug administration, with many instances of reduced activity. Terpenes are a class of compounds with anthelmintic activity. Read More

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http://dx.doi.org/10.3390/molecules25132958DOI Listing

Transcriptomic analysis of hookworm Ancylostoma ceylanicum life cycle stages reveals changes in G-protein coupled receptor diversity associated with the onset of parasitism.

Int J Parasitol 2020 Jun 24. Epub 2020 Jun 24.

Department of Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington DC, USA. Electronic address:

Free-living nematodes respond to variable and unpredictable environmental stimuli whereas parasitic nematodes exist in a more stable host environment. A positive correlation between the presence of environmental stages in the nematode life cycle and an increasing number of G-protein coupled receptors (GPCRs) reflects this difference in free-living and parasitic lifestyles. As hookworm larvae move from the external environment into a host, they detect uncharacterized host components, initiating a signaling cascade that results in the resumption of development and eventual maturation. Read More

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http://dx.doi.org/10.1016/j.ijpara.2020.05.003DOI Listing

FecalNet: Automated detection of visible components in human feces using deep learning.

Med Phys 2020 Jun 24. Epub 2020 Jun 24.

Specialized Laboratory for Medical Detection, Shenzhen Baoan Women's and Children's Hospital, Shenzhen, 518071, China.

Purpose: To automate the detection and identification of visible components in feces for early diagnosis of gastrointestinal diseases, we propose FecalNet, a method using multiple deep neural networks.

Methods: FecalNet uses the ResNet152 residual network to extract and learn the characteristics of visible components in fecal microscopic images, acquire feature maps in combination with the feature pyramid network, apply the full convolutional network to classify and locate the fecal components, and implement the improved focal-loss function to re-optimize the classification results. This allowed the complete automation of the detection and identification of the visible components in feces. Read More

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http://dx.doi.org/10.1002/mp.14352DOI Listing

The increased sensitivity of qPCR in comparison to Kato-Katz is required for the accurate assessment of the prevalence of soil-transmitted helminth infection in settings that have received multiple rounds of mass drug administration.

Parasit Vectors 2020 Jun 24;13(1):324. Epub 2020 Jun 24.

Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, W2 1PG, UK.

Background: The most commonly used diagnostic tool for soil-transmitted helminths (STH) is the Kato-Katz (KK) thick smear technique. However, numerous studies have suggested that the sensitivity of KK can be problematic, especially in low prevalence and low intensity settings. An emerging alternative is quantitative polymerase chain reaction (qPCR). Read More

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http://dx.doi.org/10.1186/s13071-020-04197-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315547PMC

The impact of four years of semiannual treatments with albendazole alone on lymphatic filariasis and soil-transmitted helminth infections: A community-based study in the Democratic Republic of the Congo.

PLoS Negl Trop Dis 2020 Jun 23;14(6):e0008322. Epub 2020 Jun 23.

French National Research Institute for Sustainable Development, Montpellier, France.

Background: The World Health Organization now recommends semiannual mass drug administration (MDA) of albendazole with integrated vector management as an option for eliminating lymphatic filariasis (LF) in areas of loiasis-endemic countries where it may not be safe to use diethylcarbamazine or ivermectin in MDA programs. However, the published evidence base to support this policy is thin, and uptake by national programs has been slow.

Methodology/principal Findings: We conducted a community trial to assess the impact of semiannual MDA on lymphatic filariasis and soil-transmitted helminth infections (STH) in two villages in the Bandundu province of the Democratic Republic of the Congo with moderately high prevalences for LF and hookworm infections. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008322DOI Listing

The Effect of Pregnancy in the Hemoglobin Concentration of Pregnant Women: A Longitudinal Study.

J Pregnancy 2020 3;2020:2789536. Epub 2020 Jun 3.

Department of Pediatrics and Child Health Wolkite University, Butajira General Hospital, Ethiopia.

Background: The objective of this study was to estimate and identify the determinants of hemoglobin concentration before pregnancy, during pregnancy, and after labor and delivery.

Methods: A prospective cohort study design was implemented. Data were collected from May 2015 to September 2018. Read More

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http://dx.doi.org/10.1155/2020/2789536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290874PMC

Contribution of and Leaves Flour to Nutrient Intake and Effect on Nutritional Status of Rural School Children in Volta Region, Ghana.

J Nutr Metab 2020 2;2020:1015280. Epub 2020 Jun 2.

School of Public Health, University of Health and Allied Sciences, PMB 31, Ho, Ghana.

Background: Plant-based foods are staple diets and main micronutrient sources of most rural Ghanaian households. The objective of this study was to determine the effect of and leafy vegetable flour on micronutrient intake and nutritional status of rural Ghanaian school children.

Method: This study was a randomized controlled trial that consisted of baseline data collection and a three-month nutrition intervention feeding program. Read More

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http://dx.doi.org/10.1155/2020/1015280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288204PMC

Exploring Tropical Infections: A Focus on Cutaneous Larva Migrans.

Adv Skin Wound Care 2020 Jul;33(7):356-359

Student, Cumming School of Medicine, University of Calgary, Alberta, Canada Assistant Professor, Departments of Medicine, Microbiology, Immunology & Infectious Disease, Community Health Sciences, University of Calgary, Alberta, Canada Clinical Assistant Professor, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

General Purpose: To provide information about infection with cutaneous larva migrans (CLM).

Target Audience: This continuing education activity is intended for physicians, physician assistants, NPs, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will:1. Read More

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http://dx.doi.org/10.1097/01.ASW.0000662248.18996.b5DOI Listing

High-throughput multiplex qPCRs for the surveillance of zoonotic species of canine hookworms.

PLoS Negl Trop Dis 2020 Jun 15;14(6):e0008392. Epub 2020 Jun 15.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia.

The canine hookworms Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma caninum and Uncinaria stenocephala are not only capable of producing morbidity and mortality in dogs but are also neglected tropical zoonoses. Each hookworm species differs considerably in its geographical distribution, life cycle, biology, pathogenic impacts on both canine and human hosts, zoonotic potential, and response to treatment with anthelminthics. Here we describe the development and validation of two Taq-Man based multiplex PCR assays capable of detecting and differentiating all four canine hookworm species in faeces of naturally infected dogs. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316352PMC

Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial.

JAMA Neurol 2020 Jun 15. Epub 2020 Jun 15.

Immune Regulation Research Group, University of Nottingham, Nottingham, England.

Importance: Studies suggest gut worms induce immune responses that can protect against multiple sclerosis (MS). To our knowledge, there are no controlled treatment trials with helminth in MS.

Objective: To determine whether hookworm treatment has effects on magnetic resonance imaging (MRI) activity and T regulatory cells in relapsing MS. Read More

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http://dx.doi.org/10.1001/jamaneurol.2020.1118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296452PMC

Prevalence of Intestinal Parasitic Infestation among Public School Children of a Community.

JNMA J Nepal Med Assoc 2020 May 30;58(225):293-296. Epub 2020 May 30.

Department of Microbiology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Introduction: Intestinal parasitic infestation is one of the major health problems in developing countries like Nepal. This study was done to determine the prevalence rate of intestinal parasitic infestation among school children in Duwakot VDC, Bhaktapur, Nepal.

Methods: A descriptive cross-sectional study was done in 194 public school children of Duwakot village development committee from August to October, 2019. Read More

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http://dx.doi.org/10.31729/jnma.4892DOI Listing

Dogs and pigs are transport hosts of Necator americanus: Molecular evidence for a zoonotic mechanism of human hookworm transmission in Ghana.

Zoonoses Public Health 2020 Jun 11. Epub 2020 Jun 11.

Yale School of Medicine, New Haven, CT, USA.

Hookworm infection (Necator americanus and Ancylostoma spp) causes significant morbidity in resource-limited countries. Dog and pig ownership is associated with human infection, although the mechanism through which animals increase risk remains unknown. We first confirmed this association in Kintampo North, Ghana, using a retrospective analysis and serology, followed by a prospective molecular study of animal faeces. Read More

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http://dx.doi.org/10.1111/zph.12708DOI Listing
June 2020
2.065 Impact Factor

Enteric parasitic infections in children and dogs in resource-poor communities in northeastern Brazil: Identifying priority prevention and control areas.

PLoS Negl Trop Dis 2020 Jun 9;14(6):e0008378. Epub 2020 Jun 9.

Departamento de Ciências Agrárias e Ambientais, Programa de Pós-Graduação em Ciência Animal, Universidade Estadual de Santa Cruz-UESC, Ilhéus, Bahia, Brasil.

The aim of this study was to determine the prevalence and risk factors of the main enteric parasitic infections that affect children and dogs in the municipality of Ilhéus, Bahia, Brazil; and to identify the geopolitical areas that should receive priority interventions to combat them. Between March and November 2016, fecal samples of 143 dogs and 193 children aged 1 month to 5 years were collected in 40 rural and semirural communities using a systematic sampling approach, stratified by district. Samples were collected by legal guardians of the children and / or dog owners. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282628PMC

Distribution of ascariasis, trichuriasis and hookworm infections in Ogun State, Southwestern Nigeria.

PLoS One 2020 8;15(6):e0233423. Epub 2020 Jun 8.

Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Nigeria.

Background: Ascariasis, Trichuriasis and Hookworm infections poses a considerable public health burden in Sub-Saharan Africa, and a sound understanding of their spatial distribution facilitates to better target control interventions. This study, therefore, assessed the prevalence of the trio, and mapped their spatial distribution in the 20 administrative regions of Ogun State, Nigeria.

Methods: Parasitological surveys were carried out in 1,499 households across 33 spatially selected communities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233423PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279584PMC

Epidemiology and risk factors of Strongyloides stercoralis infection in Papua, Indonesia: a molecular diagnostic study.

Acta Trop 2020 Jun 4;209:105575. Epub 2020 Jun 4.

Postgraduate Programme in Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Center for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. Electronic address:

Strongyloides stercoralis is a parasitic worm that is of considerable clinical relevance. Indeed, it may persist asymptomatically for many years, but can lead to potentially fatal dissemination when the host's immune status is impaired. As commonly employed stool microscopy techniques (e. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105575DOI Listing

Epidemiology of intestinal helminthiases in a rural community of Ethiopia: Is it time to expand control programs to include Strongyloides stercoralis and the entire community?

PLoS Negl Trop Dis 2020 Jun 4;14(6):e0008315. Epub 2020 Jun 4.

National Center for Tropical Medicine, Institute of Health Carlos III, Madrid, Spain.

Background: Soil transmitted helminths are highly prevalent worldwide. Globally, approximately 1.5 billion people are infected with Ascaris lumbricoides, Trichuris trichiura or hookworm. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297378PMC

Host Population Expansion and the Genetic Architecture of the Pinniped Hookworm Uncinaria lucasi.

J Parasitol 2020 Jun;106(3):383-391

Department of Entomology and Nematology, University of California Davis, Davis, California 95616.

The long-term fidelity of pinniped hosts to their natal rookery site suggests the genetic architecture of their Uncinaria spp. hookworms should be strongly structured by host breeding biology. However, historical events affecting host populations may also shape parasite genetic structure. Read More

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http://dx.doi.org/10.1645/19-172DOI Listing

Detection of gastrointestinal parasitism at recreational canine sites in the USA: the DOGPARCS study.

Parasit Vectors 2020 Jun 1;13(1):275. Epub 2020 Jun 1.

Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USA.

Background: The rapid growth in off-leash dog parks provides opportunity for canine socialization activities but carries risk of exposure to intestinal parasites. This study assessed the prevalence of these infections in dogs visiting off-leash dog parks.

Methods: Fresh defecations were collected from dogs visiting parks in 30 metropolitan areas across the USA. Read More

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http://dx.doi.org/10.1186/s13071-020-04147-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268625PMC

Hookworm diagnosed during colonoscopy and terminal ileum intubation.

Endoscopy 2020 May 29. Epub 2020 May 29.

Alimentary Tract Research Center, Ahvaz Imam Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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http://dx.doi.org/10.1055/a-1173-8265DOI Listing

Combined use of chemical and biological compounds to control hookworm.

J Helminthol 2020 Jun 1;94:e160. Epub 2020 Jun 1.

Pharmaceutical Science Graduate Program, Universidade Vila Velha - UVV, Minas Gerais, Brazil.

The aim of this study was to evaluate the combined use of different chemical (albendazole, ivermectin, glycerine and Vaseline) and biological (Monacrosporium thaumasium) compounds in the control of Ancylostoma caninum. Infective larvae of A. caninum were obtained from coprocultures of positive faeces from naturally infected dogs. Read More

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http://dx.doi.org/10.1017/S0022149X20000334DOI Listing

Efficacy of a single dose versus a multiple dose regimen of Mebendazole against hookworm infections among school children: a randomized open-label trial.

BMC Infect Dis 2020 May 27;20(1):376. Epub 2020 May 27.

Department of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P.O.Box: 196, Gondar, Ethiopia.

Background: Despite the existence of a population-based control program using single dose albendazole or mebendazole as a preventive chemotherapy, hookworm transmission remains high. It causes a negative impact on the growth and school performance of children. In connection to this preventive chemotherapy, different studies produced conflicting results. Read More

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http://dx.doi.org/10.1186/s12879-020-05097-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251741PMC
May 2020
2.613 Impact Factor

Opportunistic Mapping of and Hookworm in Dogs in Remote Australian Communities.

Pathogens 2020 May 21;9(5). Epub 2020 May 21.

Faculty of Science and Engineering, Flinders University, Bedford Park, SA 5042, Australia.

Both S and hookworms are common soil-transmitted helminths in remote Australian communities. In addition to infecting humans, and some species of hookworms infect canids and therefore present both environmental and zoonotic sources of transmission to humans. Currently, there is limited information available on the prevalence of hookworms and infections in dogs living in communities across the Northern Territory in Australia. Read More

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http://dx.doi.org/10.3390/pathogens9050398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281600PMC

Comprehensive analysis of the secreted proteome of adult Necator americanus hookworms.

PLoS Negl Trop Dis 2020 05 26;14(5):e0008237. Epub 2020 May 26.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.

The human hookworm Necator americanus infects more than 400 million people worldwide, contributing substantially to the poverty in these regions. Adult stage N. americanus live in the small intestine of the human host where they inject excretory/secretory (ES) products into the mucosa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274458PMC

Performance of two serodiagnostic tests for loiasis in a Non-Endemic area.

PLoS Negl Trop Dis 2020 05 26;14(5):e0008187. Epub 2020 May 26.

IRCCS Sacro Cuore Don Calabria Hospital, Center for Tropical Diseases, Negrar, Verona, Italy.

Loiasis, caused by the filarial nematode Loa loa, is endemic in Central and West Africa where about 10 million people are infected. There is a scarcity of convenient, commercial diagnostics for L. loa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274468PMC

Effectiveness of Mass Drug Administration on Neglected Tropical Diseases in Schoolchildren in Zanzibar, Tanzania.

Korean J Parasitol 2020 Apr 30;58(2):109-119. Epub 2020 Apr 30.

Department of Environmental Medical Biology, Institute of Tropical Medicine and Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Seoul 03722, Korea.

Soil-transmitted helminths and Schistosoma haematobium affect more than 3 billion people globally and mainly occur in sub-Saharan Africa. The present study assessed the overall infection status of a 1716-student cohort of school-children in Zanzibar and applied mass drug administration (MDA) to the cohort from 2007 to 2009. Schools in Pemba, Zanzibar, had a much higher prevalence of soil-transmitted helminth infections than those in Unguja, and the Chaani, Ghana, and Machui schools of Unguja exhibited high S. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.2.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231831PMC
April 2020
0.965 Impact Factor

Prevalence of Soil-Transmitted Helminth and Infection and Their Associated Factors among Hiruy Abaregawi Primary School Children, Rural Debre Tabor, North West Ethiopia: A Cross-Sectional Study.

J Parasitol Res 2020 29;2020:2521750. Epub 2020 Jan 29.

Debre Tabor University, College of Medicine and Health Sciences, Department of Medical Laboratory Science, Debre Tabor, Ethiopia.

Background: In Ethiopia, 25.3 and 12.3 million school-age children are living in soil-transmitted helminth and schistosomiasis endemic areas, respectively. Read More

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http://dx.doi.org/10.1155/2020/2521750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204315PMC
January 2020

Efficacy evaluation of anthelmintic products against an infection with the canine hookworm (Ancylostoma caninum) isolate Worthy 4.1F3P in dogs.

Int J Parasitol Drugs Drug Resist 2020 Apr 20;13:22-27. Epub 2020 Apr 20.

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.

Ancylostoma caninum is the most prevalent intestinal nematode of dogs, and has a zoonotic potential. Multiple-drug resistance (MDR) has been confirmed in a number of A. caninum isolates, including isolate Worthy 4. Read More

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http://dx.doi.org/10.1016/j.ijpddr.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214830PMC

Prevalence and Associated Risk Factors of , , and Intestinal Parasites among Food Handlers in Motta Town, North West Ethiopia.

Can J Infect Dis Med Microbiol 2020 13;2020:6425946. Epub 2020 Jan 13.

University of Gondar, College of Medicine and Health Sciences, School of Biomedical and Laboratory Sciences, Department of Medical Microbiology, Gondar, Ethiopia.

Background: Intestinal parasite, , and infections are the main public health concerns in the world, especially in developing countries due to inaccessibility of safe water and unhygienic food handling practices of food handlers.

Methods: A cross-sectional study was conducted in food handlers in Motta town, from February 2019 to April 2019. The study was undertaken to determine the prevalence and associated risk factors of , and intestinal parasites among 243 food handlers. Read More

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http://dx.doi.org/10.1155/2020/6425946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201477PMC
January 2020

Predictors of Intestinal Parasitic Infection among Food Handlers Working in Madda Walabu University, Ethiopia: A Cross-Sectional Study.

Interdiscip Perspect Infect Dis 2020 17;2020:9321348. Epub 2020 Jan 17.

School of Health Science, Madda Walabu University, P.O. Box 302, Bale-Robe, Ethiopia.

Background: Intestinal parasitic infection is one of the major health problems globally. It is more common in developing countries including Ethiopia. So, adequate evidence is needed regarding the predictors of intestinal parasitic infection. Read More

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http://dx.doi.org/10.1155/2020/9321348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201448PMC
January 2020

Soil-transmitted helminthiasis in four districts in Bangladesh: household cluster surveys of prevalence and intervention status.

BMC Public Health 2020 May 12;20(1):672. Epub 2020 May 12.

Elimination of Lymphatic Filariasis & STH Control Program, Directorate General of Health Services, Ministry of Health & Family Welfare, Road # 29, New DOHS, Mohakhali, Dhaka, Bangladesh.

Background: In 2016, after 8 years of twice-annual nationwide preventive chemotherapy (PC) administration to school-age children (SAC), the Bangladesh Ministry of Health & Family Welfare (MOHFW) sought improved impact and intervention monitoring data to assess progress toward the newly adopted goal of eliminating soil-transmitted helminthiasis (STH) as a public health problem.

Methods: We surveyed four Bangladeshi districts between August and October 2017. We conducted a multi-stage, cluster-sample, household survey which produced equal-probability samples for preschool-age children (PSAC; 1-4 years), SAC (5-14 years), and adults (≥ 15 years). Read More

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http://dx.doi.org/10.1186/s12889-020-08755-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218586PMC

Toxocariasis: A neglected infection for the Anthropocene epoch.

Authors:
Peter J Hotez

Adv Parasitol 2020 6;109:879-883. Epub 2020 Apr 6.

Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States; Hagler Institute for Advanced Studies at Texas A&M University, College Station, TX, United States; Department of Biology, Baylor University, Waco, TX, United States; James A Baker III Institute of Public Policy, Rice University, Houston, TX, United States; Scowcroft Institute of International Affairs, Bush School of Government and Public Service, Texas A&M University, College Station, TX, United States. Electronic address:

While ascariasis, trichuriasis, and hookworm infection dominate global efforts to control human soil-transmitted helminth infections, a picture is unfolding to suggest that toxocariasis is now a fourth and perhaps equally important parasitic disease. Toxocara eggs are widespread in the environment and practically ubiquitous in the soils of many subtropical and tropical regions of Asia, Africa, and the Americas. Human zoonotic infection is also highly prevalent in these areas, based on serologic studies to detect anti-Toxocara antibodies. Read More

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http://dx.doi.org/10.1016/bs.apar.2020.03.004DOI Listing

Intensity of Nematode Infection in Children Aged 3 to 5 Years Living in Mukuru Kwa Njenga Slum Settlement, Nairobi, Kenya.

J Trop Med 2020 14;2020:4124808. Epub 2020 Apr 14.

Embakasi Medical Health Centre and Mukuru Health Centre, P.O. Box 30108-00100, Nairobi, Kenya.

Background: The burden of nematode infections is high mostly in children below 5 years old, with clinical manifestations ranging from mild to painful symptoms due to severe infections that end up suppressing the immune system of the infected children. The occurrence of these infections is highest in areas of extreme poverty. This study evaluated the intensity of nematode infections and assessed the status of deworming in children aged 3 to 5 years living in Mukuru slum settlement, Nairobi County, Kenya. Read More

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http://dx.doi.org/10.1155/2020/4124808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178522PMC

Zoonotic Ancylostomiasis: An Update of a Continually Neglected Zoonosis.

Am J Trop Med Hyg 2020 Apr 27. Epub 2020 Apr 27.

Faculty for Veterinary and Agricultural Sciences, The University of Melbourne, Melbourne, Australia.

Hookworm infections are classified as the most impactful of the human soil-transmitted helminth (STH) infections, causing a disease burden of ∼4 million disability-adjusted life years, with a global prevalence of 406-480 million infections. Until a decade ago, epidemiological surveys largely assumed and as the prevalent human hookworm species implicated as contributing to iron-deficiency anemia. This assumption was based on the indistinguishable morphology of the spp. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0060DOI Listing

Assessing expanded community wide treatment for schistosomiasis: Baseline infection status and self-reported risk factors in three communities from the Greater Accra region, Ghana.

PLoS Negl Trop Dis 2020 04 27;14(4):e0007973. Epub 2020 Apr 27.

Department of Biomedical and Public Health Research, Council for Scientific and Industrial Research-Water Research Institute, Council Close, Accra, Ghana.

Background: This paper reports on the baseline prevalence and associated risk factor findings of a pilot, longitudinal study exploring community-wide treatment of schistosomiasis and soil-transmitted helminthiasis, using albendazole plus praziquantel in the Greater Accra region of Ghana.

Method: From three communities, at least, 658 individuals were enrolled into the study via random household selection. Prevalence and intensity of schistosomiasis and STH infection were determined from stool and urine samples with a questionnaire being administered in order to explore other morbidities and risk factors. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205311PMC

Deep learning for wireless capsule endoscopy: a systematic review and meta-analysis.

Gastrointest Endosc 2020 Apr 22. Epub 2020 Apr 22.

Department of Diagnostic Imaging, Sheba Medical Center, Tel Hashomer, Israel; and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; DeepVision Lab, Sheba Medical Center, Tel Hashomer, Israel.

Background And Aims: Deep learning is an innovative algorithm based on neural networks. Wireless capsule endoscopy (WCE) is considered the criterion standard for detecting small-bowel diseases. Manual examination of WCE is time consuming and can benefit from automatic detection using artificial intelligence (AI). Read More

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http://dx.doi.org/10.1016/j.gie.2020.04.039DOI Listing

Comparison of multi-parallel qPCR and double-slide Kato-Katz for detection of soil-transmitted helminth infection among children in rural Bangladesh.

PLoS Negl Trop Dis 2020 04 24;14(4):e0008087. Epub 2020 Apr 24.

Division of Epidemiology & Biostatistics, University of California, Berkeley, Berkeley, California, United States of America.

There is growing interest in local elimination of soil-transmitted helminth (STH) infection in endemic settings. In such settings, highly sensitive diagnostics are needed to detect STH infection. We compared double-slide Kato-Katz, the most commonly used copromicroscopic detection method, to multi-parallel quantitative polymerase chain reaction (qPCR) in 2,799 stool samples from children aged 2-12 years in a setting in rural Bangladesh with predominantly low STH infection intensity. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202662PMC

Effect of Ancylostoma ceylanicum hookworm platelet inhibitor on platelet adhesion and peripheral blood mononuclear cell proliferation.

Parasitol Res 2020 Jun 16;119(6):1777-1784. Epub 2020 Apr 16.

Guangdong Provincial Zoonosis Prevention and Control Key Laboratory, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510542, China.

Ancylostoma ceylanicum is a zoonotic parasitic nematode that can cause iron-deficiency anemia and malnutrition in humans. A. ceylanicum hookworm platelet inhibitor (Ace-HPI) can inhibit platelet aggregation in the host to facilitate blood sucking, but whether it possesses platelet adhesion inhibitory activity or immunomodulatory role is yet unknown. Read More

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http://dx.doi.org/10.1007/s00436-020-06678-4DOI Listing

Identification of High-Risk Pregnancies in a Remote Setting Using Ambulatory Blood Pressure: The MINDI Cohort.

Front Public Health 2020 24;8:86. Epub 2020 Mar 24.

School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, QC, Canada.

Ambulatory blood pressure is a potential tool for early detection of complications during pregnancy, but its utility in impoverished settings has not been assessed. This cross-sectional study aimed to determine whether maternal infections, nutrient deficiencies and inflammation (MINDI) were associated with four measures of maternal blood pressure (BP) and to determine their association with symphysis-fundal-height (SFH). Environmental and dietary factors, intake of iron and a multiple-nutrient supplement (MNS), markers of inflammation, protein, anemia, folate, vitamins B, A and D status, and urogenital, skin, oral and intestinal nematode infections were measured in indigenous pregnant Panamanian women. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121149PMC

Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites.

PLoS Pathog 2020 04 9;16(4):e1008465. Epub 2020 Apr 9.

School of Biomedical Science, Faculty of Biological Sciences & Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom.

Roundworm parasite infections are a major cause of human and livestock disease worldwide and a threat to global food security. Disease control currently relies on anthelmintic drugs to which roundworms are becoming increasingly resistant. An alternative approach is control by vaccination and 'hidden antigens', components of the worm gut not encountered by the infected host, have been exploited to produce Barbervax, the first commercial vaccine for a gut dwelling nematode of any host. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173941PMC

Zoonotic Gastrointestinal Parasites of Baboons () in the Shai Hill Reserve in Ghana.

Biomed Res Int 2020 11;2020:1083251. Epub 2020 Mar 11.

Kumasi Centre for Collaborative Research into Tropical Medicine, UPO, PMB KNUST, Kumasi, Ghana.

Several intestinal parasites of baboons are of zoonotic importance, especially where there is considerable interaction between the baboons and humans. The identification of gastrointestinal parasite infections of baboons () was undertaken at the Shai Hills Reserve Resort, Ghana. A total of 51 faecal samples were collected randomly from individual baboons (51) and examined for cysts, eggs, and larvae of parasites of medical importance, using the direct saline smear and formol-ether concentration technique. Read More

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http://dx.doi.org/10.1155/2020/1083251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086414PMC

A holistic approach is needed to control the perpetual burden of soil-transmitted helminth infections among indigenous schoolchildren in Malaysia.

Pathog Glob Health 2020 05 5;114(3):145-159. Epub 2020 Apr 5.

Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

A cross-sectional survey was conducted among 1,142 Orang Ali schoolchildren in six states of Peninsular Malaysia to investigate the current prevalence and risk factors of STH infections. Faecal samples were examined using direct smear, formalin-ether sedimentation, Kato-Katz, and Harada-Mori methods. A pre-tested questionnaire was used to collect information on the demographic, socioeconomic, personal hygiene, and health status of the participants. Read More

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http://dx.doi.org/10.1080/20477724.2020.1747855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241489PMC
May 2020
0.841 Impact Factor

Dafachronic acid and temperature regulate canonical dauer pathways during Nippostrongylus brasiliensis infectious larvae activation.

Parasit Vectors 2020 Apr 1;13(1):162. Epub 2020 Apr 1.

Department of Biology, Millersville University of Pennsylvania, Millersville, PA, 17551, USA.

Background: While immune responses to the murine hookworm Nippostrongylus brasiliensis have been investigated, signaling pathways regulating development of infectious larvae (iL3) are not well understood. We hypothesized that N. brasiliensis would use pathways similar to those controlling dauer development in the free-living nematode Caenorhabditis elegans, which is formally known as the "dauer hypothesis. Read More

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http://dx.doi.org/10.1186/s13071-020-04035-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110753PMC

Design, expression, and evaluation of novel multiepitope chimeric antigen of Wuchereria bancrofti for the diagnosis of lymphatic filariasis - A structure-based strategy.

Int Immunopharmacol 2020 Jun 26;83:106431. Epub 2020 Mar 26.

CSIR-National Chemical Laboratory, Organic Chemistry Division, Pune 411008, Maharashtra, India.

The Global Program for Elimination Lymphatic Filariasis (GPELF) is in an advanced stage and requires tools for diagnosing infection, assessing transmission and certification. This study was aimed at developing an antibody-based assay using a chiemric antigen containing multi-B-cell epitopes from antigens highly expressed in different stages of Wuchereria bancrofti to detect LF infection and its transmission. The antigen was express cloned and two indirect ELISA based (IgG1 & IgG4 based) antibody assays were developed using the recombinant antigen. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106431DOI Listing

Central Latin America: Two decades of challenges in neglected tropical disease control.

PLoS Negl Trop Dis 2020 03 26;14(3):e0007962. Epub 2020 Mar 26.

Departments of Pediatrics and Molecular Virology & Microbiology, Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0007962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098567PMC

Prevalence of Parasitic Contamination of Cockroaches Collected from Fresh Markets in Chachoengsao Province, Thailand.

Kobe J Med Sci 2020 Feb 10;65(4):E118-E123. Epub 2020 Feb 10.

Department of Public Health, Faculty of Science and Technology, Rajabhat Rajanagarindra University, Chachoengsao, Thailand.

Cockroaches are the greatest potential mechanical vector of various pathogenic microorganisms. This study aimed to determine the prevalence and species type of human pathogenic parasite infestations on the external body surface of the cockroaches. A total of 450 cockroaches collected from three fresh markets were identified in three species belonging to Periplaneta americana, Periplaneta brunnea and Periplaneta australasiae. Read More

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February 2020