6,727 results match your criteria Hookworm


Burden and factors associated with schistosomiasis and soil-transmitted helminth infections among school-age children in Huambo, Uige and Zaire provinces, Angola.

Infect Dis Poverty 2022 Jun 25;11(1):73. Epub 2022 Jun 25.

The Mentor Initiative, Luanda, Angola.

Background: Schistosomiasis and soil-transmitted helminths (STHs) contribute high disease burdens amongst the neglected tropical diseases (NTDs) and are public health problems in Angola. This study reports the prevalence, intensity and risk factors for schistosomiasis and STH infection in Huambo, Uige and Zaire provinces, Angola, to inform a school-based preventive chemotherapy program.

Methods: A two-stage cluster design was used to select schools and schoolchildren to participate in parasitological and water, sanitation and hygiene (WASH) surveys across Huambo, Uige, and Zaire provinces. Read More

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Clinical Presentation and Intensity of Infection with Intestinal Helminths among School Children in Ile-Ife, Osun State, Nigeria.

West Afr J Med 2022 Jun;39(6):568-572

Department of Internal Medicine, Lagos University Teaching Hospital, Idi-Araba, Lagos State, Nigeria.

Background: Intestinal helminthiases are public health problems of children in developing countries of the world and account for significant morbidity as it results in stunted growth, intestinal obstruction, anaemia, cognitive impairment, acute pancreatitis, acute cholecystitis and rectal prolapse. This study assessed intestinal helminths, infection intensity and symptoms in primary school children in Ile-Ife.

Methods: It was a cross sectional study. Read More

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Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway.

Pharmaceuticals (Basel) 2022 May 27;15(6). Epub 2022 May 27.

Laboratory of Intestinal Immunology, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in disadvantaged communities. Infections can cause high morbidity due to their impact on nutrient uptake and their need to feed on host blood, resulting in a loss of iron and protein, which can lead to severe anaemia and impaired cognitive development in children. Currently, only one drug, albendazole is efficient to treat hookworm infection and the scientific community fears the rise of resistant strains. Read More

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coinfection is associated with improved IgE and IgG3 response against hookworm antigens.

Health Sci Rep 2022 Jul 14;5(4):e672. Epub 2022 Jun 14.

Department of Biomedical Sciences, School of Allied Health Sciences University of Cape Coast Cape Coast Ghana.

Background: and Hookworm infections are prevalent in West Africa and they cause iron deficiency anemia and protein malnutrition in Children. Immune response of these parasites interact and their interactions could have repercussions on vaccine development and efficacy. The current goal of hookworm eradication lies on vaccination. Read More

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Interventions to improve water, sanitation, and hygiene for preventing soil-transmitted helminth infection.

Cochrane Database Syst Rev 2022 06 21;6:CD012199. Epub 2022 Jun 21.

Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

Background: It is estimated that 1.5 billion people are infected with soil-transmitted helminths (STHs) worldwide. Re-infection occurs rapidly following deworming, and interruption of transmission is unlikely without complementary control efforts such as improvements in water, sanitation, and hygiene (WASH) access and behaviours. Read More

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Human hookworms from Argentina: Differential diagnosis of Necator americanus and Ancylostoma duodenale in endemic populations from Buenos Aires and Misiones.

Rev Argent Microbiol 2022 Jun 17. Epub 2022 Jun 17.

Centro de Estudios Parasitológicos y de Vectores (CEPAVE-CONICET-UNLP), La Plata, Buenos Aires, Argentina.

Hookworm infection is endemic in many countries throughout the world; however, the information about the prevalence of each species, Necatoramericanus and Ancylostomaduodenale, is inaccurate in many South American countries. We aimed to determine the prevalence of human hookworm species by combining the results of both microscopy and PCR among endemic populations in Argentina, represented by natives and immigrants. A total of 140 serial fecal specimens were obtained from natives in the province of Misiones and an immigrant community living in the province of Buenos Aires. Read More

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Plant-derived compounds for the treatment of schistosomiasis: Improving efficacy via nano-drug delivery.

Niger J Clin Pract 2022 Jun;25(6):747-764

Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria.

Schistosomiasis is a neglected infectious tropical disease that is second in occurrence only to hookworm infection in sub-Saharan Africa. Presently, chemotherapy is the main method of control and treatment of this disease due to the absence of a vaccine. However, Praziquantel, which is the only chemotherapeutic option, lacks efficacy against the early developmental stages of schistosomes. Read More

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Prevalence of intestinal parasitic infections versus knowledge, attitudes and practices of male residents in Brazilian urban slums: a cross-sectional study.

Rev Inst Med Trop Sao Paulo 2022 10;64:e41. Epub 2022 Jun 10.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Rio de Janeiro, Rio de Janeiro, Brazil.

Intestinal parasitic infections (IPIs) are neglected diseases caused by helminths and protozoa, with the relationships between parasite, host and environment having the potential to produce high morbidity and incapacity to work and mortality in vulnerable areas. This study assessed the prevalence of IPIs concerning socio-environmental conditions and analyzed the knowledge, attitudes and practices related to these diseases among men living in the slums of Rio de Janeiro city, Rio de Janeiro State, Brazil. A cross-sectional study was conducted in an agglomeration of urban slums between 2018 and 2019, with men aged between 20 and 59 years. Read More

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National surveillance of hookworm disease in China: A population study.

PLoS Negl Trop Dis 2022 06 9;16(6):e0010405. Epub 2022 Jun 9.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.

Background: Hookworm disease is endemic in China and is widespread globally. The disease burden to humans is great.

Methods: The study described the national surveillance of hookworm implemented in 31 provinces/autonomous regions/municipalities (P/A/Ms) of China in 2019. Read More

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Mapping the global distribution of Strongyloides stercoralis and hookworms by ecological niche modeling.

Parasit Vectors 2022 Jun 8;15(1):197. Epub 2022 Jun 8.

Instituto de Investigaciones de Enfermedades Tropicales (IIET), Sede Regional Orán Universidad Nacional de Salta, Salta, Argentina.

Background: The WHO has established a control strategy for Strongyloides stercoralis in school-aged children as well as targets and to maintain control programs for Ascaris lumbricoides, Trichuris trichiura and hookworms. For an efficient development of control programs, it is necessary to know the target countries around the world, as well as the areas within each country where efforts should be focused. Therefore, maps that provide information on the areas at risk for soil-transmitted helminth (STH) infections on a national and sub-national scale would allow for a better allocation of resources. Read More

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Clinical helminth infections alter host gut and saliva microbiota.

PLoS Negl Trop Dis 2022 06 8;16(6):e0010491. Epub 2022 Jun 8.

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok Thailand.

Background: Previous reports show altered gut bacterial profiles are associated with helminth infected individuals. Our recently published molecular survey of clinical helminthiases in Thailand border regions demonstrated a more comprehensive picture of infection prevalence when Kato Katz microscopy and copro-qPCR diagnostics were combined. We revealed that Opisthorchis viverrini, hookworm, Ascaris lumbricoides and Trichuris trichiura were the most predominant helminth infections in these regions. Read More

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Resistance to single dose albendazole and reinfection with intestinal helminths among children ages 2 to 11 years from the Peruvian Amazon region: a study protocol.

BMC Infect Dis 2022 Jun 7;22(1):528. Epub 2022 Jun 7.

Division of Infectious Diseases and International Health, Department of Internal Medicine, University of Virginia, MR-6 Rm 2207, 345 Crispell Dr, Charlottesville, VA, 22908, USA.

Background: Deworming programs aimed at reducing morbidity and mortality from geohelminth infections are common in many countries where these infections are endemic, but data demonstrating increasing levels of resistance to albendazole and mebendazole are causes for concern. Studies to evaluate the clinical efficacy of deworming programs are critical to maintain high infection control goals.

Methods: We propose to assess the clinical efficacy of Peruvian national guidelines for deworming programs in a prospective observational study conducted in the Amazon River basin area near Iquitos, Peru. Read More

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Assessing the role of eosinophil-mediated immune response markers in detecting hookworm infection: A case-control study in Kintampo, Ghana.

Health Sci Rep 2022 Jul 3;5(4):e674. Epub 2022 Jun 3.

Parasitology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences University of Ghana Legon Ghana.

Background And Aim: Human hookworm disease caused by and is a serious public health problem. Hookworm infection activates eosinophil-mediated tissue inflammatory responses, involving the production of the eosinophil-specific chemokine (eotaxin), recruitment of eosinophils, secretion of the cationic protein, and production of antiparasite immunoglobulin E (IgE). We investigated eosinophil-mediated immune response as markers (CCL11, eosinophil cationic protein [ECP], and IgE) for detecting hookworm infection. Read More

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Administration of Hookworm Excretory/Secretory Proteins Improves Glucose Tolerance in a Mouse Model of Type 2 Diabetes.

Biomolecules 2022 Apr 26;12(5). Epub 2022 Apr 26.

Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia.

Diabetes is recognised as the world's fastest growing chronic condition globally. Helminth infections have been shown to be associated with a lower prevalence of type 2 diabetes (T2D), in part due to their ability to induce a type 2 immune response. Therefore, to understand the molecular mechanisms that underlie the development of T2D-induced insulin resistance, we treated mice fed on normal or diabetes-promoting diets with excretory/secretory products (ES) from the gastrointestinal helminth . Read More

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Using quantitative PCR to identify opportunities to strengthen soil-transmitted helminth control in Solomon Islands: A cross-sectional epidemiological survey.

PLoS Negl Trop Dis 2022 05 23;16(5):e0010350. Epub 2022 May 23.

The Kirby Institute, University of New South Wales, Sydney, Australia.

Background: The Kato-Katz microscopy technique is the global standard for assessment of soil-transmitted helminth (STH) burden. However, major limitations include its poor sensitivity, requirement for rapid sample processing, and inability to differentiate hookworm species nor detect Strongyloides spp. infections. Read More

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A novel use of a geometric morphometric technique to distinguish human parasite eggs of twelve different species.

Exp Parasitol 2022 Jul 18;238:108281. Epub 2022 May 18.

Department of Public Health and Health Promotion, College of Allied Health Sciences, Suan Sunandha Rajabhat University, Bangkok, Thailand. Electronic address:

Copro-microscopic diagnostic methods are the most common approach for screening patients with parasitic infections. However, expertise is required to identify helminthic eggs from fecal specimens. Consequently, new methods are required to support accurate species identification. Read More

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Community-wide prevalence and intensity of soil-transmitted helminthiasis and Schistosoma mansoni in two districts of Sierra Leone.

PLoS Negl Trop Dis 2022 05 20;16(5):e0010410. Epub 2022 May 20.

Helen Keller International, Regional Office for Africa, Dakar, Senegal.

In Sierra Leone, nationally powered school-based surveys have documented significant progress in the control of soil-transmitted helminthiasis (STH) and schistosomiasis. In order to assess the district-level prevalence and intensity of infection among key at-risk groups outside of school age children (SAC), we conducted a multi-stage, cluster-sample household survey in Bo and Kenema districts in May 2018. From both districts, we examined 1,282 pre-school age children (PSAC), 730 school age children (SAC), and 517 adults over 14 years (including 387 women of reproductive age, or WRA) for STH and Schistosoma mansoni infection using Kato Katz technique. Read More

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Prevalence of Intestinal Parasite Infections and Associated Factors among Pregnant Women in Northwest Ethiopia.

J Parasitol Res 2022 9;2022:9065425. Epub 2022 May 9.

Department of Midwifery, College of Health Science, Debre Markos University, Debre Markos, Ethiopia.

Background: Intestinal parasite infections are among the most common infections worldwide. They pose a high burden in pregnant women in developing countries causing maternal anemia, low birth weight, and prenatal mortality. This study is aimed at assessing intestinal parasite infection prevalence, species diversity, and associated factors among pregnant women. Read More

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Impact of Three to Five Rounds of Mass Drug Administration on Schistosomiasis and Soil-Transmitted Helminths in School-Aged Children in North-Central Nigeria.

Am J Trop Med Hyg 2022 May 16. Epub 2022 May 16.

The Carter Center, Atlanta, Georgia.

Nasarawa and Plateau states of north-central Nigeria have implemented programs to control schistosomiasis (SCH) and soil-transmitted helminths (STH) in children since the 1990s. Statewide mapping surveys were conducted in 2013, when 11,332 school-aged children were sampled from 226 schools. The local government areas (LGAs) then received varying combinations of mass drug administration (MDA) for the next 5 years. Read More

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Malaria and Helminthic Co-Infection during Pregnancy in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2022 04 29;19(9). Epub 2022 Apr 29.

Armauer Hansen Research Institute, Ministry of Health, Addis Ababa 1005, Ethiopia.

Malaria and helminthic co-infection during pregnancy causes fetomaternal haemorrhage and foetal growth retardation. This study determined the pooled burden of pregnancy malaria and helminthic co-infection in sub-Saharan Africa. CINAHL, EMBASE, Google Scholar, Scopus, PubMed, and Web of Science databases were used to retrieve data from the literature, without restricting language and publication year. Read More

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A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.

Sci Adv 2022 05 11;8(19):eabj6894. Epub 2022 May 11.

Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm , with an envelope protein genetically related to G-G glycoproteins from the family Phenuiviridae. Read More

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Global distribution of human hookworm species and differences in their morbidity effects: a systematic review.

Lancet Microbe 2022 Jan 28;3(1):e72-e79. Epub 2021 Sep 28.

Curtin University Faculty of Health Sciences, Perth, WA, Australia; Telethon Kids Institute, Perth, WA, Australia.

The global distribution and morbidity effects for each specific hookworm species is unknown, which prevents implementation of the optimum intervention for local hookworm control. We did two systematic reviews of studies on the proportion of hookworm isolates of each species and genus by region of the world and associations between hookworm species-specific infections and morbidity outcomes, particularly severe anaemia. Necator americanus and Ancylostoma spp were present in all regions of the world, although at different ratios. Read More

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January 2022

Developing Immune Profiles of Endangered Australian Sea Lion () Pups Within the Context of Endemic Hookworm () Infection.

Front Vet Sci 2022 21;9:824584. Epub 2022 Apr 21.

Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Sydney, NSW, Australia.

As a top predator, the endangered Australian sea lion () is a sentinel of ecosystem change, where population trends can reflect broader shifts in the marine environment. The population of this endemic pinniped was historically diminished by commercial sealing, and recovery has been slowed by fishery interactions, disease and, potentially, pollutants. Hookworm infects 100% of neonatal pups and has been identified as a contributor to population decline. Read More

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[Travel vaccines: what is in the pipeline?]

Rev Med Suisse 2022 May;18(780):890-893

Policlinique de médecine tropicale, voyages et vaccinations, Centre de médecine générale et santé publique, Unisanté, 1011 Lausanne.

While no vaccine is on the horizon to prevent traveler's diarrhea, progress has been made in the field of malaria and dengue fever. In both cases, the objective is not primarily the prevention among travelers but rather the reduction of morbidity and mortality in populations living in endemic areas. The immune mechanisms protecting against parasitosis are not well understood, which further complicates vaccine development. Read More

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Interventions for Neglected Tropical Diseases Among Children and Adolescents: A Meta-analysis.

Pediatrics 2022 05;149(Suppl 5)

Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan.

Background: Neglected tropical diseases (NTDs) are a group of communicable diseases affecting the poorest populations around the world.

Objective: To assess the effectiveness of interventions, including mass drug administration (MDA), water, sanitation, and hygiene (WASH), vector control, health education, and micronutrients supplementation, for NTDs among children and adolescents.

Methods: We conducted a literature search on the Cochrane Controlled Trials Register, Medline, and other databases until December 2020. Read More

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Eprinomectin 5% w/v extended-release injection for the treatment of larval and/or adult Bunostomum phlebotomum, Haemonchus contortus, H. placei, Nematodirus helvetianus, Oesophagostomum radiatum, and Trichostrongylus colubriformis infections in cattle.

Parasitol Res 2022 Jul 3;121(7):2173-2178. Epub 2022 May 3.

Boehringer Ingelheim Vetmedica GmbH, Kathrinenhof Research Center, Walchenseestr. 8-12, 83101, Rohrdorf, Germany.

In an effort to generate data for regulatory purposes on the therapeutic efficacy of eprinomectin 5% w/v extended-release injection (Eprinomectin ERI) (LongRange®, Boehringer Ingelheim) against infections of immature and adult stages of some nematode species (or stages) which are generally less common or predominantly seen in younger cattle, nine studies (minimum two per parasite and stage) were conducted in the USA and Germany. A total of 218 young cattle were included in seven experimentally induced infection studies (180 animals) and two studies with naturally acquired nematode infections (38 animals), which were compliant with WAAVP and VICH guidelines. In each study, cattle were randomly assigned into groups which received 1 mL per 50 kg body weight of either saline (controls) or Eprinomectin ERI (equivalent to 1 mg eprinomectin per kg body weight) via subcutaneous injection when the parasites were developing fourth-stage larval (L4) or adult nematodes. Read More

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Prevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopia.

PLoS Negl Trop Dis 2022 04 28;16(4):e0010299. Epub 2022 Apr 28.

Mundo Sano Foundation and Institute of Health Carlos III, Madrid, Spain.

Background: Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. Read More

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Prevalence of Intestinal Helminths among Cancer Patients Who Are under Chemotherapy at the University of Gondar Comprehensive Specialized Hospital Oncology Clinic, Northwest Ethiopia.

J Cancer Epidemiol 2022 18;2022:4484183. Epub 2022 Apr 18.

Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Science, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.

Background: In developing countries, environmental and personal hygiene is playing a great role in the increasing of intestinal helminth infection. In countries with limited resources and poor hygiene practices, there is a substantial overlap of intestinal helminthic and chronic infections like HIV, TB, and cancer. Intestinal helminths like , , and hookworm cause malnutrition and induce a type-2 immune response that could worsen the severity and clinical outcomes of patients with cancer. Read More

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Prevalence and effect of Plasmodium spp. and hookworm co-infection on malaria parasite density and haemoglobin level: a meta-analysis.

Sci Rep 2022 04 27;12(1):6864. Epub 2022 Apr 27.

Medical Technology, School of Allied Health Sciences, Walailak University, Tha Sala, Nakhon Si Thammarat, Thailand.

The dual effects of co-infection of Plasmodium spp. and hookworm on malaria remain under debate. This study investigated prevalence, prevalence odds ratio (POR) of co-infection and impact of co-infection on malaria parasite density and haemoglobin levels in comparison to Plasmodium mono-infection. Read More

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Ancylostoma in dogs in the Caribbean: a review and study from St. Kitts, West Indies.

Parasit Vectors 2022 Apr 21;15(1):139. Epub 2022 Apr 21.

Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.

Background: Little is known about the prevalence of Ancylostoma in dogs in the Caribbean. In view of the number of owned free-roaming and feral dogs within the islands and the ideal subtropical climate for parasite development and environmental survival, Ancylostoma could pose a threat to the health of the dogs as well as a zoonotic risk to people.

Methods: To determine whether generalities about Ancylostoma in dogs in the Caribbean could be made and to obtain a better understanding of the prevalence, published (Scielo, Scopus, and PubMed databases) and gray (e. Read More

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