6,121 results match your criteria Hookworm


Good manufacturing practices of minimally processed vegetables reduce contamination with pathogenic microorganisms.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e14. Epub 2019 Feb 14.

Universidade de Brasília, Faculdade de Medicina, Laboratório de Parasitologia Médica e Biologia de Vetores, Brasília, Distrito Federal, Brazil.

Consumption of ready-to-eat (RTE) vegetables is quick, easy and healthy, especially when eaten without cooking. However, they might be a source of foodborne pathogenic microorganisms. The objective of this study was to evaluate the microbiological and parasitological contamination of fresh RTE vegetables produced in agroindustries in the Federal District of Brazil (FD), and to correlate contamination with good manufacturing practices (GMP). Read More

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http://dx.doi.org/10.1590/S1678-9946201961014DOI Listing
February 2019

Isolation and characterization of a naturally occurring multidrug-resistant strain of the canine hookworm, Ancylostoma caninum.

Int J Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology, Immunology, and Tropical Medicine, Ross Hall, 2300 I St. NW, The George Washington University, Washington, DC, 20052, USA. Electronic address:

Soil-transmitted nematodes (STNs) infect over a billion people and place several billion more at risk of infection. Hookworm disease is the most significant of these STNs, with over 500 million people infected. Hookworm infection can result in debilitating and sometimes fatal iron-deficiency anemia, which is particularly devastating in children and pregnant women. Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.12.004DOI Listing
February 2019
1 Read

Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar.

PLoS Negl Trop Dis 2019 Feb 15;13(2):e0006591. Epub 2019 Feb 15.

Department of Infectious Disease Epidemiology, School of Public Health, Faculty of Medicine, Imperial College London, London, United Kingdom.

Background: Mass drug administration (MDA), targeted at school-aged children (SAC) is the method recommended by the World Health Organization for the control of morbidity induced by soil-transmitted helminth (STH) infection in endemic countries. However, MDA does not prevent reinfection between treatment rounds and research suggests that only treating SAC will not be sufficient to bring prevalence to low levels and possibly interrupt transmission of STH. In countries with endemic infection, such as Myanmar, the coverage, who is targeted, and rates of reinfection will determine how effective MDA is in suppressing transmission in the long-term. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006591DOI Listing
February 2019

Ovicidal and larvicidal effects of extracts from leaves of Andrographis paniculata (Burm. f.) Wall.ex Nees against field isolates of human hookworm (Ancylostoma duodenale).

J Ethnopharmacol 2019 Feb 11. Epub 2019 Feb 11.

Department of Biological Science, Adamawa State University, P.M.B. 25, Mubi, Nigeria. Electronic address:

Ethnopharmacological Relevance: The whole plant of Andrographis paniculata (Burm. f.) Wall. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.021DOI Listing
February 2019
1 Read
2.998 Impact Factor

Pharmacokinetics of albendazole, albendazole sulfoxide and albendazole sulfone determined from plasma, blood, dried blood spots and Mitra® samples of hookworm-infected adolescents.

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland

Albendazole is an effective anthelmintic intensively used for decades. However, profound pharmacokinetic (PK) characterization is missing in children, the population mostly affected by helminth infections. Blood micro-sampling would facilitate PK studies in pediatric populations but has not been applied to quantify albendazole's disposition. Read More

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http://dx.doi.org/10.1128/AAC.02489-18DOI Listing
February 2019
2 Reads

Genetic Markers of Benzimidazole Resistance among Human Hookworms () in Kintampo North Municipality, Ghana.

Am J Trop Med Hyg 2019 Feb;100(2):351-356

Yale Partnerships for Global Health, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.

Hookworm infection causes anemia, malnutrition, and growth delay, especially in children living in sub-Saharan Africa. The World Health Organization recommends periodic mass drug administration (MDA) of anthelminthics to school-age children (SAC) as a means of reducing morbidity. Recently, questions have been raised about the effectiveness of MDA as a global control strategy for hookworms and other soil-transmitted helminths (STHs). Read More

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http://dx.doi.org/10.4269/ajtmh.18-0727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367626PMC
February 2019

Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism.

Parasitol Res 2019 Jan 29. Epub 2019 Jan 29.

Departamento de Parasitologia, L4 237, Laboratório de Parasitologia Molecular, Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270-901, Belo Horizonte, Minas Gerais, Brazil.

Mass drug administration has been implicated as the major cause of drug resistance in nematodes of ruminants. Single-nucleotide polymorphisms (SNPs) at codons 167, 198, and 200 of the beta-tubulin isotype 1 gene are associated with albendazole resistance mechanisms. Although drug resistance is suspected to occur in nematodes of the same order, at present, there is no evidence of a strong correlation between these canonical SNPs and albendazole resistance in hookworms. Read More

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http://link.springer.com/10.1007/s00436-019-06218-9
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http://dx.doi.org/10.1007/s00436-019-06218-9DOI Listing
January 2019

Epidemiology of Hookworm Infection in the School-age Children: A Comparative Cross-sectional Study.

Iran J Parasitol 2018 Oct-Dec;13(4):560-566

Dept. of Epidemiology and Biostatistics, University of Bahir Dar, Bahir Dar, Ethiopia.

Background: Globally more than 740 million peoples are infected with hookworm. In sub-Saharan Africa, approximately 200 million people have been infected with hookworm, 90 million of them were children. The objective of this study was to identify the prevalence and determinant factors of hookworm infection in urban and rural school-age children's. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348213PMC
January 2019
1 Read
0.872 Impact Factor

China's shifting neglected parasitic infections in an era of economic reform, urbanization, disease control, and the Belt and Road Initiative.

PLoS Negl Trop Dis 2019 01 24;13(1):e0006946. Epub 2019 Jan 24.

Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0006946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345419PMC
January 2019
9 Reads

Gene structure and expression patterns of Acdaf-1, a TGF-β type I receptor in Ancylostoma caninum.

Parasitol Res 2019 Jan 22. Epub 2019 Jan 22.

State Key Laboratory of Cellular Stress Biology, School of Life Science, Xiamen University, Xiamen, 361005, Fujian, People's Republic of China.

The components of the transforming growth factor β (TGF-β) signaling pathway in parasitic nematodes remain unknown. In this research, a type I receptor for TGF-β was isolated from the hookworm Ancylostoma caninum. The new gene was designated as Acdaf-1, a Caenorhabditis elegans daf-1 homolog. Read More

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http://dx.doi.org/10.1007/s00436-018-6142-xDOI Listing
January 2019

Hookworm-derived metabolites suppress pathology in a mouse model of colitis and inhibit secretion of key inflammatory cytokines in primary human leukocytes.

Infect Immun 2019 Jan 22. Epub 2019 Jan 22.

Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia.

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral blood mononuclear cells, we demonstrate that low molecular weight metabolites derived from both somatic extracts (LMWM-SE) and excretory-secretory products (LMWM-ESP) of the hookworm, display anti-inflammatory properties. Administration to mice of LMWM-ESP as well as sequentially extracted fractions of LMWM-SE using both methanol (SE-MeOH) and hexane: dichloromethane: acetonitrile (SE-HDA) resulted in significant protection against T cell-mediated immunopathology, clinical signs of colitis and impaired histological colon architecture. Read More

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http://dx.doi.org/10.1128/IAI.00851-18DOI Listing
January 2019
4 Reads
3.731 Impact Factor

Analysis of Schistosomiasis and soil-transmitted helminths mixed infections among pupils in Enugu State, Nigeria: Implications for control.

Infect Dis Health 2019 Jan 12. Epub 2019 Jan 12.

Department of Parasitology and Entomology, Faculty of Biosciences, Nnamdi Azikiwe University, P.M.B 5025, Awka, Anambra State, Nigeria. Electronic address:

Background: Schistosomiasis and Soil-transmitted helminthiasis cause considerable morbidity and mortality in developing countries, especially among children. To this end it, a cross-sectional survey to determine the pattern of Schistosomiasis and Soil-transmitted helminthiasis co-infection was undertaken among primary school pupils in Oduma Community in Enugu State, Nigeria.

Methods: Fresh urine and stool samples were collected from pupils. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680451183016
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http://dx.doi.org/10.1016/j.idh.2018.12.003DOI Listing
January 2019
3 Reads

Substrate type and age are risk factors for gastrointestinal parasitism in greyhound kennels.

Vet Parasitol 2019 Jan 7;265:7-14. Epub 2018 Dec 7.

School of Veterinary and Life Sciences, Murdoch University, South Street, Perth 6150 Australia; Andersons Moores Veterinary Specialists, The Granary, Bunstead Barns, Poles Ln, Hursley, UK.

The control of parasitic infections is particularly challenging in environments that are conducive to the maintenance of parasite lifecycles, such as the greyhound kennel, where the long-term breeding and rearing of dogs is common. The prevalence of gastrointestinal (GI) parasites within the Australian greyhound population has never previously been assessed, which seriously constrains the implementation of effective control measures. The aims of this study were to determine the prevalence and risk factors for GI parasites in Australian greyhounds, identify parasites which may be detrimental to the health and performance of dogs, and evaluate the likelihood of zoonotic transmission to kennel staff. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.11.013DOI Listing
January 2019
1 Read

Intestinal hookworm infestation causing chronic anaemia.

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Digestive and Interventional Endoscopy Unit, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, Italy.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22812
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http://dx.doi.org/10.1136/bcr-2018-228120DOI Listing
January 2019
6 Reads

Overview of Deep Learning in Gastrointestinal Endoscopy.

Gut Liver 2019 Jan 11. Epub 2019 Jan 11.

Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Artificial intelligence is likely to perform several roles currently performed by humans, and the adoption of artificial intelligence-based medicine in gastroenterology practice is expected in the near future. Medical image-based diagnoses, such as pathology, radiology, and endoscopy, are expected to be the first in the medical field to be affected by artificial intelligence. A convolutional neural network, a kind of deep-learning method with multilayer perceptrons designed to use minimal preprocessing, was recently reported as being highly beneficial in the field of endoscopy, including esophagogastroduodenoscopy, colonoscopy, and capsule endoscopy. Read More

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http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
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http://dx.doi.org/10.5009/gnl18384DOI Listing
January 2019
12 Reads

Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.

PLoS Negl Trop Dis 2019 01 10;13(1):e0007086. Epub 2019 Jan 10.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Introduction: Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343929PMC
January 2019
5 Reads

Prevalence of parasitic contamination of raw vegetables in Nakhon Si Thammarat province, southern Thailand.

BMC Public Health 2019 Jan 8;19(1):34. Epub 2019 Jan 8.

Department of Tropical Pathology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.

Background: Soil-transmitted helminth (STH) infections are major public health problems in poor and developing countries that require fecal contamination of the environment for transmission. The consumption of raw vegetables without proper washing is one of the main routes of intestinal parasite acquisition. Therefore, this study was designed to detect the prevalence of intestinal parasitic contamination in commonly consumed raw vegetables sold in three central open-air markets in Nakhon Si Thammarat province, southern Thailand. Read More

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http://dx.doi.org/10.1186/s12889-018-6358-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323832PMC
January 2019
1 Read

Human Hookworm Infection Enhances Mycobacterial Growth Inhibition and Associates With Reduced Risk of Tuberculosis Infection.

Front Immunol 2018 14;9:2893. Epub 2018 Dec 14.

Nuffield Department of Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom.

Soil-transmitted helminths and frequently coincide geographically and it is hypothesized that gastrointestinal helminth infection may exacerbate tuberculosis (TB) disease by suppression of Th1 and Th17 responses. However, few studies have focused on latent TB infection (LTBI), which predominates globally. We performed a large observational study of healthy adults migrating from Nepal to the UK ( = 645). Read More

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http://dx.doi.org/10.3389/fimmu.2018.02893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302045PMC
December 2018

Intestinal parasitic infestations and anemia among urban female school children in Kancheepuram district, Tamil Nadu.

J Family Med Prim Care 2018 Nov-Dec;7(6):1395-1400

Department of Community Medicine, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chrompet, Chennai, Tamil Nadu, India.

Introduction: In India, intestinal parasitic infection and anemia remain the most important cause of morbidity especially among the adolescent school children due to lack of awareness of personal hygiene practices, leading to intestinal parasite infections which could in turn lead to anemia.

Aim: This study was conducted with the aim to find out the prevalence of intestinal parasitic infection and anemia among adolescent female school children in an urban area of Tamil Nadu.

Materials And Method: This descriptive cross-sectional study was done among adolescent female school children in Anakaputhur area of Kancheepuram district. Read More

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http://www.jfmpc.com/text.asp?2018/7/6/1395/246524
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http://dx.doi.org/10.4103/jfmpc.jfmpc_89_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293916PMC
January 2019
5 Reads

Health, financial, and education gains of investing in preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, and lymphatic filariasis in Madagascar: A modeling study.

PLoS Negl Trop Dis 2018 12 27;12(12):e0007002. Epub 2018 Dec 27.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston MA, United States of America.

Background: Neglected tropical diseases (NTDs) account for a large disease burden in sub-Saharan Africa. While the general cost-effectiveness of NTD interventions to improve health outcomes has been assessed, few studies have also accounted for the financial and education gains of investing in NTD control.

Methods: We built on extended cost-effectiveness analysis (ECEA) methods to assess the health gains (e. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007002
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http://dx.doi.org/10.1371/journal.pntd.0007002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307713PMC
December 2018
11 Reads

Deworming in non-pregnant adolescent girls and adult women: a systematic review and meta-analysis.

Syst Rev 2018 Dec 20;7(1):239. Epub 2018 Dec 20.

Bruyère Research Institute, Bruyère, 310 - 85 Primrose Avenue E, Ottawa, ON, K1R 7G5, Canada.

Background: The impact of deworming on parasite load, nutritional status and other health outcomes of non-pregnant adolescent girls and adult women is uncertain.

Methods: MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Controlled Trials, the WHO International Clinical Trials Registry Platform, the Cochrane Database of Systematic Reviews and Food and Technology Abstracts databases were searched until 24 September 2018. Studies were included if they were randomised controlled trials (RCTs), controlled before and after studies or interrupted time studies comparing deworming with no intervention or placebo in non-pregnant adolescent girls and women 10 to 49 years old. Read More

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https://systematicreviewsjournal.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s13643-018-0859-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300900PMC
December 2018
5 Reads

[Investigation on intestinal nematode infections and their risk factors in Shanpo Sub-district, Jiangxia District, Wuhan City].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 May;30(5):567-570

Department of Human Parasitology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Objective: To investigate the infection status of intestinal nematodes and their risk factors in rural residents of Jiangxia District, Wuhan City, so as to provide the reference for the establishment of targeted prevention and control measures.

Methods: According to the requirements of cross-sectional study of the national human key parasitic diseases, the residents in Shanpo Sub-district, Jiangxia District were randomly selected as the objects for the investigation of the infection status of , hookworm and . A questionnaire survey was performed simultaneously. Read More

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http://dx.doi.org/10.16250/j.32.1374.2017159DOI Listing
May 2018
10 Reads

Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patent Mansonella perstans filariasis.

Clin Exp Immunol 2018 Dec 18. Epub 2018 Dec 18.

National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokodé, Togo.

Mansonella perstans (Mp) filariasis is present in large populations in sub-Saharan Africa, and to what extent patent Mp infection modulates the expression of immunity in patients, notably their cellular cytokine and chemokine response profile, remains not well known. We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-γ (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). Freshly isolated peripheral mononuclear blood cells (PBMC) were stimulated with helminth, protozoan and bacterial antigens and mitogen [phytohaemagglutinin (PHA)]. Read More

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http://dx.doi.org/10.1111/cei.13251DOI Listing
December 2018
2 Reads

The burden and epidemiology of polyparasitism among rural communities in Kano State, Nigeria.

Trans R Soc Trop Med Hyg 2018 Dec 14. Epub 2018 Dec 14.

Department of Parasitology, Faculty of Medicine, University of Malaya,Kuala Lumpur, Malaysia.

Background: Parasitic infections constitute a major public health problem worldwide, particularly among underprivileged communities in developing countries including Nigeria. The present study aimed to determine the epidemiology of polyparasitism (multiple parasitic infections) among rural communities in Kano State, North Central Nigeria.

Methods: A total of 551 individuals were screened for the presence of intestinal, urogenital and blood parasites by using different diagnostic techniques. Read More

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http://dx.doi.org/10.1093/trstmh/try128DOI Listing
December 2018
1 Read
1.931 Impact Factor

Prevalence and correlates of anemia among adolescents in Nepal: Findings from a nationally representative cross-sectional survey.

PLoS One 2018 14;13(12):e0208878. Epub 2018 Dec 14.

Department of Paediatrics, the University of Melbourne, Melbourne, Australia.

Anemia is regarded as major public health problem among adolescents in Low and Middle-Income Countries (LMICs) but there is limited primary data in many countries, including Nepal. This study investigated the prevalence and correlates of anemia in a nationally representative sample of adolescents within the 2014 National Adolescent Nutrition Survey in Nepal. A total of 3780 adolescents aged 10 to 19 years were selected from a cross-sectional survey through multi-stage cluster sampling. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208878PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294609PMC
December 2018
2 Reads

Prevalence of intestinal parasites and the absence of soil-transmitted helminths in Añatuya, Santiago del Estero, Argentina.

Parasit Vectors 2018 Dec 14;11(1):638. Epub 2018 Dec 14.

Fundación Mundo Sano, Paraguay, 1535, Buenos Aires, Argentina.

Background: Intestinal parasites (IP) have been reported in point studies from different provinces of Argentina. The presence of soil-transmitted helminths (STH) was detected in many of these studies, including varied prevalences of all five species of STH in the north were the climate is more appropriate for transmission. Nonetheless, Argentina lacks a comprehensive prevalence map of STH. Read More

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http://dx.doi.org/10.1186/s13071-018-3232-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295026PMC
December 2018

A comparison of helminth infections as assessed through coprological analysis and adult worm burdens in a wild host.

Int J Parasitol Parasites Wildl 2018 Dec 14;7(3):439-444. Epub 2018 Nov 14.

Department of Zoology, School of Natural Sciences, Trinity College Dublin, Ireland.

Coprological analysis is the most widely used diagnostic tool for helminth infection in both domestic and wild mammals. Evaluation of the efficacy of this technique is rare, due to the lack of availability of adult worm burden. Where information is available the majority of studies are in small ruminants and seldom in a wild host. Read More

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http://dx.doi.org/10.1016/j.ijppaw.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261086PMC
December 2018

Fortification of Carica papaya fruit seeds to school meal snacks may aid Africa mass deworming programs: a preliminary survey.

BMC Complement Altern Med 2018 Dec 7;18(1):327. Epub 2018 Dec 7.

The Graduate School, Kenya Medical Research Institute, Mbagathi Road, Nairobi, P.O. BOX 54840, Kenya.

Background: Soil transmitted helminths (STHs) are among the world's neglected tropical diseases. Morbidity due to STHs is greatest in school-age children who typically have the highest burden of infection. In 2001, WHO passed a resolution for the use of large-scale mass drug administration (MDA) to deworm vulnerable children through school based programs. Read More

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https://bmccomplementalternmed.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12906-018-2379-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286506PMC
December 2018
6 Reads

Mitochondrial DNA reveals species composition and phylogenetic relationships of hookworms in northeastern Brazil.

Infect Genet Evol 2019 Mar 30;68:105-112. Epub 2018 Nov 30.

Laboratory of Epidemiology and Molecular Systematics, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; Oswaldo Cruz Foundation, Teresina, Piauí, Brazil. Electronic address:

Hookworm infection persists focally in rural communities in Brazil. In this study, we analyze the mitochondrial nucleotide sequences obtained from hookworms infecting humans in order to characterize species composition and assess their genetic diversity and phylogenetic relationships. Field expeditions and cross-sectional surveys were carried out in three Brazilian municipalities from 2013 to 2017: Nossa Senhora de Nazaré (n = 605) and Teresina (n = 297), in the state of Piauí, and Russas (n = 213) in the State of Ceará. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348183071
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http://dx.doi.org/10.1016/j.meegid.2018.11.018DOI Listing
March 2019
10 Reads

Efficacy and safety of ascending dosages of tribendimidine against hookworm infections in children: a randomized controlled trial.

Clin Infect Dis 2018 Nov 29. Epub 2018 Nov 29.

Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: The global strategy to control soil-transmitted helminthiasis is mainly focused on preventive chemotherapy based on albendazole and mebendazole. We assessed the efficacy and safety of ascending tribendimidine doses against hookworm infections in African school-aged children, key information to be able to include tribendimidine in preventive deworming campaigns.

Methods: We performed a single blind randomized controlled trial in Côte d'Ivoire between June and August 2017. Read More

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http://dx.doi.org/10.1093/cid/ciy999DOI Listing
November 2018

Efficacy and safety of a new topical formulation of selamectin plus sarolaner in the treatment and control of natural infections of Ancylostoma tubaeforme and Toxocara cati in cats presented as veterinary patients in the United States.

Vet Parasitol 2018 Nov 11. Epub 2018 Nov 11.

Zoetis, Veterinary Medicine Research and Development, 333 Portage Street, Kalamazoo, MI, 49007, USA.

A new topical formulation of selamectin plus sarolaner (Revolution Plus/Stronghold Plus, Zoetis) was evaluated in the treatment and control of naturally occurring infections of Ancylostoma tubaeforme and Toxocara cati in cats presented as veterinary patients in the United States. Three thousand three hundred three (3303) cats were screened in 25 veterinary practices in 15 states and 153 hookworm-positive cats (A. tubaeforme and/or A. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.10.012DOI Listing
November 2018
2 Reads

The public health benefit and burden of mass drug administration programs in Vietnamese schoolchildren: Impact of mebendazole.

PLoS Negl Trop Dis 2018 11 12;12(11):e0006954. Epub 2018 Nov 12.

Department of Green Chemistry and Technology, Ghent University, Campus Coupure, Ghent, Belgium.

Background: Mass anthelmintic drug administration is recommended in developing countries to address infection by soil-transmitted helminthiases (STH). We quantified the public health benefit of treatment with mebendazole in eight million Vietnamese children aged 5-14 years from 2006 to 2011. This was compared to the environmental impact of the pharmaceutical supply chain of mebendazole, as the resource use and emissions associated with pharmaceutical production can be associated with a public health burden, e. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006954
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http://dx.doi.org/10.1371/journal.pntd.0006954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258429PMC
November 2018
7 Reads

Anemia and its association with coffee consumption and hookworm infection among pregnant women attending antenatal care at Debre Markos Referral Hospital, Northwest Ethiopia.

PLoS One 2018 8;13(11):e0206880. Epub 2018 Nov 8.

Department of Health Informatics, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Anemia in pregnancy is a major public health concern worldwide, especially in developing countries. Thus, there is a need of having current information and local data on the prevalence of anemia and associated factors during pregnancy to help inform preventive programmes. The aim of this study was to assess the prevalence of anemia and associated factors among pregnant women attending antenatal care at Debre Markos Referral Hospital, Northwest Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206880PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224100PMC
November 2018
4 Reads

The people behind the samples: Biographical features of Past Hunter-Gatherers from KwaZulu-Natal who yielded aDNA.

Int J Paleopathol 2019 Mar 3;24:158-164. Epub 2018 Nov 3.

Centre for Anthropological Research, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, South Africa.

Purpose: Skeletons sampled for ancient human DNA analysis are sometimes complete enough to provide information about the lives of the people they represent. We focus on three Later Stone Age skeletons, ca. 2000 B. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18799817183005
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http://dx.doi.org/10.1016/j.ijpp.2018.10.008DOI Listing
March 2019
6 Reads

Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures.

Elife 2018 11 6;7. Epub 2018 Nov 6.

Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, United States.

Increases in ocean temperature are associated with changes in the distribution of fish stocks, and the foraging regimes and maternal attendance patterns of marine mammals. However, it is not well understood how these changes affect offspring health and survival. The maternal attendance patterns and immunity of South American fur seals were assessed in a rookery where hookworm disease is the main cause of pup mortality. Read More

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https://elifesciences.org/articles/38432
Publisher Site
http://dx.doi.org/10.7554/eLife.38432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245726PMC
November 2018
19 Reads

Terror in the dirt: Sensory determinants of host seeking in soil-transmitted mammalian-parasitic nematodes.

Int J Parasitol Drugs Drug Resist 2018 12 26;8(3):496-510. Epub 2018 Oct 26.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA. Electronic address:

Infection with gastrointestinal parasitic nematodes is a major cause of chronic morbidity and economic burden around the world, particularly in low-resource settings. Some parasitic nematode species, including the human-parasitic threadworm Strongyloides stercoralis and human-parasitic hookworms in the genera Ancylostoma and Necator, feature a soil-dwelling infective larval stage that seeks out hosts for infection using a variety of host-emitted sensory cues. Here, we review our current understanding of the behavioral responses of soil-dwelling infective larvae to host-emitted sensory cues, and the molecular and cellular mechanisms that mediate these responses. Read More

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https://www.researchgate.net/scientific-contributions/135143
Web Search
https://linkinghub.elsevier.com/retrieve/pii/S22113207183011
Publisher Site
http://dx.doi.org/10.1016/j.ijpddr.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287541PMC
December 2018
10 Reads

Helminth and respiratory mite lesions in Pinnipeds from Punta San Juan, Peru.

Acta Parasitol 2018 Dec;63(4):839-844

Instituto de Patología Animal, Facultad de Ciencias Veterinarias, Universidad Austral de Chile, Isla Teja s/n, 5090000, Valdivia, Chile.

The tissues and parasites collected from Peruvian fur seals (Arctocephalus australis) and South American sea lions (Otaria byronia) found dead at Punta San Juan, Peru were examined. The respiratory mite, Orthohalarachne attenuata infected 3 out of 32 examined fur seals and 3 out of 8 examined sea lions, however caused moderate to severe lymphohistiocytic pharyngitis only in fur seals. Hookworms, Uncinaria sp, infected 6 of the 32 examined fur seals causing variable degrees of hemorrhagic and eosinophilic enteritis. Read More

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http://dx.doi.org/10.1515/ap-2018-0103DOI Listing
December 2018
1 Read

Haematophagic Caenorhabditis elegans.

Parasitology 2018 Oct 25:1-7. Epub 2018 Oct 25.

School of Pharmacy, University of Nottingham,Boots Sciences Building,University Park,Nottingham, NG7 2RD,UK.

Caenorhabditis elegans is a free-living nematode that resides in soil and typically feeds on bacteria. We postulate that haematophagic C. elegans could provide a model to evaluate vaccine responses to intestinal proteins from hematophagous nematode parasites, such as Necator americanus. Read More

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https://www.cambridge.org/core/product/identifier/S003118201
Publisher Site
http://dx.doi.org/10.1017/S0031182018001518DOI Listing
October 2018
20 Reads

[Current status of human hookworm infection in Jiangxi Province in 2014].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2018 Jun;30(4):446-448

Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330096, China.

Objective: To understand the status of human hookworm ( or ) infection in Jiangxi Province.

Methods: A stratified cluster random sampling was conducted based on the geographical location and economic condition in 2014. Kato-Katz's thick smear method was used for stool examinations, and filter paper cultivation was conducted for distinguishing the species of hookworms. Read More

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http://dx.doi.org/10.16250/j.32.1374.2017191DOI Listing
June 2018
4 Reads

Prevalence of enteric parasitic infections among people living with HIV in Abeokuta, Nigeria.

Pan Afr Med J 2018 28;30:66. Epub 2018 May 28.

Department of Medical Microbiology & Parasitology, Ladoke Akintola University of Technology, Osogbo, Nigeria.

Introduction: Enteric parasitic infections have been increasingly recognized as etiology of life-threatening chronic diarrhea in PLWHA in sub-Saharan Africa. This study investigated the prevalence and burden of intestinal parasitic infection among PLWHA in Abeokuta, southwest Nigeria.

Methods: Freshly passed stool samples were collected from PLWHA. Read More

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http://www.panafrican-med-journal.com/content/article/30/66/
Publisher Site
http://dx.doi.org/10.11604/pamj.2018.30.66.13160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191249PMC
October 2018
11 Reads

Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.

Mucosal Immunol 2019 01 18;12(1):64-76. Epub 2018 Oct 18.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, 19104, USA.

Coordinated efforts between macrophages and epithelia are considered essential for wound healing, but the macrophage-derived molecules responsible for repair are poorly defined. This work demonstrates that lung macrophages rely upon Trefoil factor 2 to promote epithelial proliferation following damage caused by sterile wounding, Nippostrongylus brasiliensis or Bleomycin sulfate. Unexpectedly, the presence of T, B, or ILC populations was not essential for macrophage-driven repair. Read More

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http://www.nature.com/articles/s41385-018-0096-2
Publisher Site
http://dx.doi.org/10.1038/s41385-018-0096-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301101PMC
January 2019
3 Reads

Modification and optimization of the FECPAKG2 protocol for the detection and quantification of soil-transmitted helminth eggs in human stool.

PLoS Negl Trop Dis 2018 10 15;12(10):e0006655. Epub 2018 Oct 15.

Department of Virology, Parasitology and Immunology, Ghent University, Merelbeke, Belgium.

Background: Standard diagnosis of human soil-transmitted helminth (STH) infections is based on the microscopic detection of helminth eggs in stool and supports programmatic decision making in control programs. However, the current standard diagnostic techniques still show a number of limitations. Recently, the FECPAKG2 method was developed to detect helminth infections and asses drug efficacy in sheep or cattle. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006655
Publisher Site
http://dx.doi.org/10.1371/journal.pntd.0006655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224113PMC
October 2018
9 Reads

Knowledge, attitude and practice with respect to soil contamination by Soil-Transmitted Helminths in Ibadan, Southwestern Nigeria.

Parasite Epidemiol Control 2018 Nov 24;3(4):e00075. Epub 2018 Sep 24.

Parasitology Unit, Department of Zoology, Faculty of Science, University of Ibadan, Oyo State, Nigeria.

, , and , the four major Soil-transmitted helminths (STHs) and also infect humans worldwide. Most studies on Soil-transmitted helminths (STHs) carried out in Ibadan were faecal examination based while relatively few soil examination based studies were carried out mostly around school premises using limited number of sampling locations. This study was therefore designed to assess the level of soil contamination with STH and associated risk factors in the eleven local government areas of Ibadan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056731183002
Publisher Site
http://dx.doi.org/10.1016/j.parepi.2018.e00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171486PMC
November 2018
3 Reads

Standardization and application of a modified RFLP-PCR methodology for analysis of polymorphisms linked to treatment resistance in Ancylostoma braziliense.

Parasit Vectors 2018 Oct 9;11(1):540. Epub 2018 Oct 9.

Departamento de Parasitologia, L4 237, Laboratório de Parasitologia Molecular, Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.

Background: Single nucleotide polymorphisms (SNPs) in codons 167, 198 and 200 of the beta-tubulin isotype 1 gene are associated with benzimidazoles resistance in many helminths. Codon 167 mutation has never been described in hookworms; however, polymorphisms in codons 198 and 200 have been described for Ancylostoma caninum and Necator americanus. These mutations have never been investigated in Ancylostoma braziliense; therefore, it is not known if they are present in this species and whether they are correlated with treatment resistance. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-018-3125-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178248PMC
October 2018
2 Reads

Zoonotic Helminth Diseases in Dogs and Dingoes Utilising Shared Resources in an Australian Aboriginal Community.

Trop Med Infect Dis 2018 Oct 8;3(4). Epub 2018 Oct 8.

College of Science and Engineering and Centre for Environmental and Sustainability Science, James Cook University, Cairns, QLD 4870, Australia.

The impacts of free-roaming canids (domestic and wild) on public health have long been a concern in Australian Indigenous communities. We investigated the prevalence of zoonotic helminth diseases in dogs and sympatric dingoes, and used radio telemetry to measure their spatial overlap, in an Aboriginal community in the Wet Tropics of Australia. Samples collected from dingoes and dogs showed high levels of infection with the zoonotic hookworm, . Read More

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http://www.mdpi.com/2414-6366/3/4/110
Publisher Site
http://dx.doi.org/10.3390/tropicalmed3040110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306763PMC
October 2018
1 Read

Young Adults in Endemic Areas: An Untreated Group in Need of School-Based Preventive Chemotherapy for Schistosomiasis Control and Elimination.

Trop Med Infect Dis 2018 Sep 5;3(3). Epub 2018 Sep 5.

School of Public Health, Department of Biomedical Sciences, Maseno University, Kisumu 40100 Kenya.

Parasitologic surveys of young adults in college and university settings are not commonly done, even in areas known to be endemic for schistosomiasis and soil-transmitted helminths. We have done a survey of 291 students and staff at the Kisumu National Polytechnic in Kisumu, Kenya, using the stool microscopy Kato-Katz (KK) method and the urine point-of-care circulating cathodic antigen (POC-CCA) test. Based on three stools/two KK slides each, in the 208 participants for whom three consecutive stools were obtained, prevalence was 17. Read More

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http://www.mdpi.com/2414-6366/3/3/100
Publisher Site
http://dx.doi.org/10.3390/tropicalmed3030100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160920PMC
September 2018
3 Reads

Involvement of Hookworm Co-Infection in the Pathogenesis and Progression of Podoconiosis: Possible Immunological Mechanism.

Trop Med Infect Dis 2018 Mar 26;3(2). Epub 2018 Mar 26.

Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos, Idi-Araba, Surulere P.M.B 12003, Lagos 100254, Nigeria.

Podoconiosis is an endemic, non-infectious, geochemical and non-filarial inflammatory cause of tropical elephantiasis. The immunology of podoconiosis is not yet expressly understood. In spite of this, co-infection and co-morbidity with the infectious, soil-transmitted hookworm disease that causes iron deficiency anemia has been found to be predominant among affected individuals living in co-endemic settings, thus creating a more complex immunological interplay that still has not been investigated. Read More

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http://www.mdpi.com/2414-6366/3/2/37
Publisher Site
http://dx.doi.org/10.3390/tropicalmed3020037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073219PMC
March 2018
2 Reads

Defining stopping criteria for ending randomized clinical trials that investigate the interruption of transmission of soil-transmitted helminths employing mass drug administration.

PLoS Negl Trop Dis 2018 10 1;12(10):e0006864. Epub 2018 Oct 1.

The DeWorm3 Project, The Natural History Museum of London, London, United Kingdom.

The current World Health Organization strategy to address soil-transmitted helminth (STH) infections in children is based on morbidity control through routine deworming of school and pre-school aged children. However, given that transmission continues to occur as a result of persistent reservoirs of infection in untreated individuals (including adults) and in the environment, in many settings such a strategy will need to be continued for very extended periods of time, or until social, economic and environmental conditions result in interruption of transmission. As a result, there is currently much discussion surrounding the possibility of accelerating the interruption of transmission using alternative strategies of mass drug administration (MDA). Read More

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http://dx.doi.org/10.1371/journal.pntd.0006864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181437PMC
October 2018
1 Read

A Survey of Intestinal Parasites of Domestic Dogs in Central Queensland.

Trop Med Infect Dis 2017 Nov 21;2(4). Epub 2017 Nov 21.

School of Health, Medical and Applied Sciences, Central Queensland University, North Rockhampton, QSD 4702, Australia.

Australia has a very high rate of dog ownership, which in some circumstances may lead to exposure to zoonotic parasitic diseases from those companion animals. Domestic dog faecal samples ( = 300) were collected from public spaces and private property in the greater Rockhampton (Central Queensland) region and tested for intestinal helminths and protozoa by direct microscopy, two flotation methods and a modified acid-fast stain for cryptosporidia. Intestinal parasites detected included hookworms (25%), complex (9%), (3%), (3%), (1%) and (1%), spp. Read More

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http://www.mdpi.com/2414-6366/2/4/60
Publisher Site
http://dx.doi.org/10.3390/tropicalmed2040060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082058PMC
November 2017
4 Reads

Schistosoma mansoni-Associated Morbidity among Preschool-Aged Children along the Shores of Lake Victoria in Uganda.

Trop Med Infect Dis 2017 Nov 5;2(4). Epub 2017 Nov 5.

Parasitology and Aquatic Pathobiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg C, Denmark.

causes morbidity in human beings, with the highest prevalence in rural sub-Saharan Africa. Prolonged infection with egg deposition in intestinal blood vessels leads to liver and spleen enlargement, and thus chronic morbidity. The objective of this study was to assess whether preschool-aged children develop severe -related morbidity. Read More

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http://www.mdpi.com/2414-6366/2/4/58
Publisher Site
http://dx.doi.org/10.3390/tropicalmed2040058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082064PMC
November 2017
3 Reads