157,268 results match your criteria Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine[Journal]


Progress toward Understanding the Interactions between DNA Nanostructures and the Cell.

Small 2019 Feb 20:e1805416. Epub 2019 Feb 20.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

Advances in DNA nanotechnology empower the programmable assembly of DNA building blocks (oligonucleotides and plasmids) into DNA nanostructures with precise architectural control. As DNA nanostructures are biocompatible and can naturally enter mammalian cells without the aid of transfection agents, they have found numerous biological or biomedical applications as delivery carriers of therapeutic and imaging cargoes into mammalian cells for at least a decade. Nevertheless, mechanistic studies on how DNA nanostructures interact with cells have remained limited and incomprehensive until 2-3 years ago. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.201805416DOI Listing
February 2019

Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients.

J Gastroenterol Hepatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medicine, Queen Mary Hospital, Hong Kong.

Background And Aim: Hepatocellular carcinoma (HCC) can still develop in chronic hepatitis B (CHB) patients receiving antiviral treatment. Serum Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel marker for liver fibrosis. We investigated its role on incidence of HCC in entecavir (ETV)-treated CHB patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jgh.14637DOI Listing
February 2019

Mandarin Chinese modality exclusivity norms.

PLoS One 2019 20;14(2):e0211336. Epub 2019 Feb 20.

Department of Chinese and Bilingual Studies, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Modality exclusivity norms have been developed in different languages for research on the relationship between perceptual and conceptual systems. This paper sets up the first modality exclusivity norms for Chinese, a Sino-Tibetan language with semantics as its orthographically relevant level. The norms are collected through two studies based on Chinese sensory words. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211336PLOS
February 2019

The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells.

FASEB J 2019 Feb 20:fj201801518RR. Epub 2019 Feb 20.

School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, China.

Previously, the V1-3 isoforms of the transient receptor potential channel (TRP) have been shown to promote or prevent adipocyte differentiation. In the current study, the C isoforms were screened for blocking adipogenesis. The hypothesis that the TRP classic or canonical (TRPC) deters adipocyte differentiation was investigated in 3T3-L1 cells employing the channel-specific activator and antagonist, silencing, and overexpression techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201801518RRDOI Listing
February 2019

How Do Adolescents Use Electronic Diaries? A Mixed-Methods Study Among Adolescents With Depressive Symptoms.

J Med Internet Res 2019 Feb 20;21(2):e11711. Epub 2019 Feb 20.

Department of Nursing Science, University of Turku, Turku, Finland.

Background: Depression in adolescence is common. Less than half of the adolescents with depression receive mental health care; furthermore, treatment tends to be suspended, and its success rates are low. There is a need for these adolescents to have a safe place to share their thoughts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/11711DOI Listing
February 2019

Focal TLR4 activation mediates disturbed flow-induced endothelial inflammation.

Cardiovasc Res 2019 Feb 20. Epub 2019 Feb 20.

Shenzhen Research Institute, Institute of Vascular Medicine, and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.

Aims: Disturbed blood flow at arterial branches and curvatures modulates endothelial function and predisposes the region to endothelial inflammation and subsequent development of atherosclerotic lesions. Activation of the endothelial Toll-like receptors (TLRs), in particular TLR4, contributes to vascular inflammation. Therefore, we investigate whether TLR4 can sense disturbed flow to mediate the subsequent endothelial inflammation. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/cardiovascres/advance-article/doi/1
Publisher Site
http://dx.doi.org/10.1093/cvr/cvz046DOI Listing
February 2019
3 Reads

Network-pharmacology-based identification of caveolin-1 as a key target of Oldenlandia diffusa to suppress breast cancer metastasis.

Biomed Pharmacother 2019 Feb 20;112:108607. Epub 2019 Feb 20.

Integrative Research Laboratory of Breast Cancer, Discipline of Integrated Chinese and Western Medicine, the Research Center of Integrative Medicine, School of Basic Medical Sciences & the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China; Post-doctoral Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:

Background: Breast cancer remains the most common female malignancy and metastasis is the leading cause of death in breast cancer patients. Oldenlandia diffusa has been empirically and extensively used as an adjuvant therapy for metastatic breast cancer patients in Traditional Chinese Medicine (TCM) with proven efficacy. However, its anti-metastasis mechanism has been poorly revealed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2019.108607DOI Listing
February 2019

Effects of foot progression angle adjustment on external knee adduction moment and knee adduction angular impulse during stair ascent and descent.

Hum Mov Sci 2019 Feb 19;64:213-220. Epub 2019 Feb 19.

Gait & Motion Analysis Laboratory, Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong. Electronic address:

Foot progression angle adjustment was shown to reduce external knee adduction moment (EKAM) and knee adduction angular impulse (KAAI) during level ground walking. However, evidence on effects of foot progression angle adjustment on the above surrogate measures of medial knee loading during stair climbing is limited. Hence, this study examined the effects of toe-in and toe-out gait on EKAM and KAAI during stair ascent and descent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humov.2019.02.004DOI Listing
February 2019

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

Eur J Med Chem 2019 Feb 12;167:485-498. Epub 2019 Feb 12.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address:

A series of novel B and C-rings truncated deguelin derivatives have been designed and synthesized in the present study as heat shock protein 90 (Hsp90) inhibitors. The synthesized compounds exhibited micromolar antiproliferative potency toward a panel of human cancer cell lines. Their structure-activity relationships (SARs) were investigated in a systematic manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2019.02.014DOI Listing
February 2019

Carbon-based materials as adsorbent for antibiotics removal: Mechanisms and influencing factors.

J Environ Manage 2019 Feb 19;237:128-138. Epub 2019 Feb 19.

College of Science, Hunan Agricultural University, Changsha, 410128, China.

With the development of the removal of organic pollutants in the soil and water environment, antibiotics have been considered as emerging pollutants and received considerable attention among the scientific community. Thus, there is a need for an effective, economical, fast, operational feasible and environmental-friendly technology to remove antibiotics. Adsorption technology would be one of the most promising option on the basis that it best meets the criteria we set out above. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2019.02.068DOI Listing
February 2019

The use of hand scanner to enhance hand hygiene practice among nursing students: A single-blinded feasibility study.

Nurse Educ Today 2019 Feb 6;76:137-147. Epub 2019 Feb 6.

School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China; Hospital Authority, Hong Kong, China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02606917183096
Publisher Site
http://dx.doi.org/10.1016/j.nedt.2019.01.013DOI Listing
February 2019
1 Read

Surface tethering of stem cells with HO-responsive anti-oxidizing colloidal particles for protection against oxidation-induced death.

Biomaterials 2019 Feb 13;201:1-15. Epub 2019 Feb 13.

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address:

Mesenchymal stem cells are the new generation of medicine for treating numerous vascular diseases and tissue defects because of their ability to secrete therapeutic factors. Poor cellular survival in an oxidative diseased tissue, however, hinders the therapeutic efficacy. To this end, we hypothesized that tethering the surface of stem cells with colloidal particles capable of discharging antioxidant cargos in response to elevated levels of hydrogen peroxide (HO) would maintain survival and therapeutic activity of the stem cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2019.01.039DOI Listing
February 2019

Direct filtration for the treatment of the coagulated domestic sewage using flat-sheet ceramic membranes.

Chemosphere 2019 Feb 11;223:383-390. Epub 2019 Feb 11.

Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China; Shenzhen Engineering Research Laboratory for Sludge and Food Waste Treatment and Resource Recovery, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China; Tsinghua-Berkeley Shenzhen Institute, Tsinghua University, Shenzhen, China. Electronic address:

Direct membrane filtration (DMF) is considered as a promising technology for municipal wastewater treatment. We utilized an innovative application of flat-sheet ceramic membranes (FSCM) for DMF for the rapid treatment of domestic sewage. Coagulation was applied before FSCM filtration to increase the pollutant removal and to mitigate membrane fouling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2019.02.055DOI Listing
February 2019

Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting.

J Am Coll Cardiol 2019 Feb;73(7):741-754

Swiss Cardiovascular Center Bern, Bern University Hospital, Bern, Switzerland. Electronic address:

Background: Complex percutaneous coronary intervention (PCI) is associated with higher ischemic risk, which can be mitigated by long-term dual antiplatelet therapy (DAPT). However, concomitant high bleeding risk (HBR) may be present, making it unclear whether short- or long-term DAPT should be prioritized.

Objectives: This study investigated the effects of ischemic (by PCI complexity) and bleeding (by PRECISE-DAPT [PREdicting bleeding Complications in patients undergoing stent Implantation and SubsequEnt Dual AntiPlatelet Therapy] score) risks on clinical outcomes and on the impact of DAPT duration after coronary stenting. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S07351097183954
Publisher Site
http://dx.doi.org/10.1016/j.jacc.2018.11.048DOI Listing
February 2019
1 Read

Kibra Modulates Learning and Memory via Binding to Dendrin.

Cell Rep 2019 Feb;26(8):2064-2077.e7

Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address:

Kibra is a synaptic scaffold protein regulating learning and memory. Alterations of Kibra-encoding gene WWC1 cause various neuronal disorders, including Alzheimer's disease and Tourette syndrome. However, the molecular mechanism underlying Kibra's function in neurons is poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.01.097DOI Listing
February 2019

Arthroscopic and Endoscopic Management of Common Complications After Displaced Intra-Articular Calcaneal Fractures.

Clin Podiatr Med Surg 2019 Apr 24;36(2):279-293. Epub 2019 Jan 24.

Guangdong Provincial Engineering Research Center of Wound Repair and Regenerative Medicine, Affiliated Baoan Hospital of Shenzhen, Southern Medical University, The 8th People's Hospital of Shenzhen, Shenzhen, Guangdong 518101, China; Guangdong Provincial Academician Workstation of Wound Repair and Regenerative Medicine, Affiliated Baoan Hospital of Shenzhen, Southern Medical University, The 8th People's Hospital of Shenzhen, Shenzhen, Guangdong 518101, China; Department of Trauma and Orthopedics, Affiliated Baoan Hospital of Shenzhen, Southern Medical University, The 8th People's Hospital of Shenzhen, Shenzhen, Guangdong 518101, China.

The list of late complications after calcaneal fracture that can be treated through arthroscopic and/or endoscopic approach continues to expand. The late complications of calcaneal fractures can be classified into 3 groups: (1) those causing focal hindfoot or ankle pain, (2) those causing functional deficit, and (3) those present with diffuse and poorly localized pain. Many group 1 and some group 2 complications can be managed arthroscopically and/or endoscopically. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cpm.2018.10.009DOI Listing

Three-dimensional biogenic C-doped BiMoO/InO-ZnO Z-scheme heterojunctions derived from a layered precursor.

J Environ Sci (China) 2019 May 31;79:54-66. Epub 2018 Oct 31.

School of Material Science and Engineering, University of Jinan, Jinan 250022, China.

Novel 3D biogenic C-doped BiMoO/InO-ZnO Z-scheme heterojunctions were synthesized for the first time, using cotton fiber as template. The as-prepared samples showed excellent adsorption and photodegradation performance toward the hazardous antibiotic doxycycline under simulated sunlight irradiation. The morphology, phase composition and in situ carbon doping could be precisely controlled by adjusting processing parameters. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jes.2018.10.011DOI Listing

Sources of methacrolein and methyl vinyl ketone and their contributions to methylglyoxal and formaldehyde at a receptor site in Pearl River Delta.

J Environ Sci (China) 2019 May 17;79:1-10. Epub 2018 Dec 17.

Institute for Environmental and Climate Research, Jinan University, Guangzhou, China. Electronic address:

Methacrolein (MACR) and methyl vinyl ketone (MVK) are two major intermediate products from the photochemical oxidation of isoprene, the most important biogenic volatile organic compound. In addition, MACR and MVK have primary emissions. Investigating the sources and evolution of MACR and MVK could provide helpful information for the oxidative capacity of the atmosphere. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jes.2018.12.001DOI Listing

Re: Eo S, Doh G, Lim S, Hong K. Analysis of the risk factors that determine composite graft survival for fingertip amputation. J Hand Surg Eur. 2018, 43:1030-35.

J Hand Surg Eur Vol 2019 Mar;44(3):328-329

Department of Burns and Plastic Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1753193418819061DOI Listing

How Chirality Determines the Selective Inhibition of Histone Deacetylase 6? A Lesson from Trichostatin A Enantiomers based on Molecular Dynamics.

ACS Chem Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Histone deacetylase 6 (HDAC6) plays a key role in a variety of neurological disorders, which makes it attractive drug target for the treatment of Alzheimer's disease, Parkinson disease and memory/learning impairment. The selectivity of HDAC6 inhibitors (sHDAC6Is) are widely considered to be susceptible to their sizes of Cap group and their physicochemical properties of linker or zinc-binding group, which makes the discovery of new sHDAC6Is extremely difficult. With the discovery of the distinct selectivity between Trichostatin A (TSA) enantiomers, the chirality residing in the connective units between TSA's Cap and linker shows a great impact on its selectivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschemneuro.8b00729DOI Listing
February 2019
1 Read

Endoscopic resection of glomangiopericytoma in 4 patients: A case series and literature review.

Clin Otolaryngol 2019 Feb 19. Epub 2019 Feb 19.

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Hong Kong, Hong Kong, China.

Glomangiopericytoma is a rare, site specific tumor arising in the sinonasal tract with borderline malignant potential. Angiography with pre-operative embolization might be indicated for large or vascular tumors to reduce operative blood loss and aid the safety of surgical operation. Complete surgical excision with free resection margin is the mainstay of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/coa.13319DOI Listing
February 2019

First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression.

J Cancer Res Clin Oncol 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon- dong, Gangnam-gu, Seoul, 135-710, South Korea.

Purpose: In the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naïve epidermal growth factor receptor mutation-positive non-small cell lung cancer. We report post hoc analyses of tolerability-guided dose adjustment for afatinib and summarize the clinical characteristics of patients who continued afatinib/gefitinib beyond initial radiological progression in LUX-Lung 7.

Methods: Patients received afatinib 40 mg/day or gefitinib 250 mg/day until investigator-assessed progression or beyond if beneficial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-019-02862-xDOI Listing
February 2019

Surgical Management of Retained Placental Tissue with the Hysteroscopic Morcellation Device.

Gynecol Minim Invasive Ther 2019 Jan-Mar;8(1):33-35. Epub 2019 Jan 23.

Department of Obstetrics and Gynecology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Conventionally, surgical management of retained placental tissue is largely performed using blind dilatation and curettage. Hysteroscopic removal using diathermy loop has been shown to be successful while increasing complete removal rates and reducing risk of uterine perforation. Our two cases demonstrated that complete removal of placental tissues can be achieved with hysteroscopic morcellation device which is known to be associated with less operative time and less operative risk compared to diathermy loop. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/GMIT.GMIT_66_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367913PMC
January 2019

The treatment of systematically transplanted gingival mesenchymal stem cells in periodontitis in mice.

Exp Ther Med 2019 Mar 11;17(3):2199-2205. Epub 2019 Jan 11.

Department of Stomatology, Key Lab of Oral Clinical Medicine, The Affiliated Hospital of Qingdao University, College of Stomatology, Qingdao University, Qingdao, Shandong 266003, P.R. China.

Cell-based tissue engineering is a promising alternative for periodontal regeneration as current therapies fail to reconstitute tissue damage caused by periodontitis. As newly identified postnatal stem cells, gingiva-derived mesenchymal stem cells (GMSCs) have been focused on for isolation and expansion of cells with multi-differentiation potential and immunomodulatory capacities. It has been demonstrated that systemically delivered GMSCs can home to the mandibular bone defect sites and promote bone regeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364184PMC

Fatigue Behavior of Inorganic-Organic Hybrid "Lunar Cement".

Sci Rep 2019 Feb 19;9(1):2238. Epub 2019 Feb 19.

Program of Materials Science and Engineering, University of California - San Diego, La Jolla, CA, 92093, USA.

We report the experimental results of fatigue behavior of ultralow-binder-content inorganic-organic hybrid (IOH) based on lunar soil simulant, which may be viewed as a "lunar cement". Under the same loading condition, the fatigue life of the IOH is superior to typical steel-reinforced concrete, especially when the stress amplitude is relatively high. Fatigue damage mostly occurs in the binder phase, followed by rapid cleavage-like failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-38799-xDOI Listing
February 2019

Green tea catechins alleviate autoimmune symptoms and visual impairment in a murine model for human chronic intraocular inflammation by inhibiting Th17-associated pro-inflammatory gene expression.

Sci Rep 2019 Feb 19;9(1):2301. Epub 2019 Feb 19.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Autoimmune uveitis is a sight-threatening disease mainly caused by dysregulation of immunity. We investigated the therapeutic effects of green tea extract (GTE) and its major component, epigallocatechin-3-gallate (EGCG), on a murine model of experimental autoimmune uveoretinitis (EAU). Oral administration of GTE, EGCG, dexamethasone, or water, which started 5 days before the induction, was fed every two days to each group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-38868-1DOI Listing
February 2019

Arbitrary order exceptional point induced by photonic spin-orbit interaction in coupled resonators.

Nat Commun 2019 Feb 19;10(1):832. Epub 2019 Feb 19.

Department of Physics, The Hong Kong University of Science and Technology, Hong Kong, China.

Many novel properties of non-Hermitian systems are found at or near the exceptional points-branch points of complex energy surfaces at which eigenvalues and eigenvectors coalesce. In particular, higher-order exceptional points can result in optical structures that are ultrasensitive to external perturbations. Here we show that an arbitrary order exceptional point can be achieved in a simple system consisting of identical resonators placed near a waveguide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08826-6DOI Listing
February 2019

A MST1-FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis.

Nat Commun 2019 Feb 19;10(1):838. Epub 2019 Feb 19.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea.

Hypoxia is a main driver of sprouting angiogenesis, but how tip endothelial cells are directed to hypoxic regions remains poorly understood. Here, we show that an endothelial MST1-FOXO1 cascade is essential for directional migration of tip cells towards hypoxic regions. In mice, endothelial-specific deletion of either MST1 or FOXO1 leads to the loss of tip cell polarity and subsequent impairment of sprouting angiogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08773-2DOI Listing
February 2019

Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages.

EMBO Rep 2019 Feb 19. Epub 2019 Feb 19.

Center for Vascular Research, Institute for Basic Science, Daejeon, Korea

A lacteal is a blunt-ended, long, tube-like lymphatic vessel located in the center of each intestinal villus that provides a unique route for drainage of absorbed lipids from the small intestine. However, key regulators for maintaining lacteal integrity are poorly understood. Here, we explore whether and how the gut microbiota regulates lacteal integrity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15252/embr.201846927DOI Listing
February 2019

Quality assessment of clinical trial registration with traditional Chinese medicine in WHO registries.

BMJ Open 2019 Feb 19;9(2):e025218. Epub 2019 Feb 19.

Chinese Clinical Trial Registry (Hong Kong), Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.

Objective: This study aimed to assess the registration quality of clinical trials (CTs) with traditional Chinese medicine (TCM) in the WHO International Clinical Trials Registry Platform (ICTRP) and identify the common problems if any.

Methods: The ICTRP database was searched for all TCM CTs that were registered up to 31 December 2017. Registered information of each trial was collected from specific registry involved in ICTRP through hyperlink. Read More

View Article

Download full-text PDF

Source
http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02521
Publisher Site
http://dx.doi.org/10.1136/bmjopen-2018-025218DOI Listing
February 2019
1 Read

Thermodynamic insights into an interaction between ACYL-COA-BINDING PROTEIN2 and LYSOPHOSPHOLIPASE2 in .

J Biol Chem 2019 Feb 19. Epub 2019 Feb 19.

The University of Hong Kong, Hong Kong.

Lysophospholipids (LPLs) are important lipid-signaling molecules in plants, of which lysophosphatidylcholine (lysoPC) is one of the most well-characterized LPLs, having important roles in plant stress responses. It is broken down by lysophospholipases, but the molecular mechanism involved in lysoPC degradation is unclear. Recombinant ACYL-COA-BINDING PROTEIN2 (AtACBP2) has been reported to bind lysoPC via its acyl-CoA-binding domain and also LYSOPHOSPHOLIPASE 2 (AtLYSOPL2) via its ankyrin repeats To investigate the interactions of AtACBP2 with AtLYSOPL2 and lysoPC in more detail, we conducted isothermal titration calorimetry (ITC) with AtACBP2, an AtACBP2 derivative consisting of amino acids 70-354, containing both the acyl-CoA-binding domain and ankyrin repeats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.006876DOI Listing
February 2019

Investigation of Dacomitinib on Reducing Cell Necrosis and Enhancing Cell Apoptosis in C6 Glioma Rat Model by MRI.

Biosci Rep 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Hainan Hospital of Hainan Medical University/Hainan General Hospital, Haikou, China.

Background: Glioma is one of the most epidemic and obstinate types of cancer in the central nervous system with poor survival rate. Dacomitinib inhibited cell viability and proliferation of  -amplified glioma. In the present study, the regional effects of Dacomitinib on tumor necrosis was investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20190006DOI Listing
February 2019

Sex-specific intergenerational trends in morbidity burden and multimorbidity status in Hong Kong community: an age-period-cohort analysis of repeated population surveys.

BMJ Open 2019 Jan 25;9(1):e023927. Epub 2019 Jan 25.

The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.

Objectives: Prevalence of multimorbidity has been increasing worldwide. While population ageing undoubtedly contributes, secular trends have seldom been decomposed into age, period and cohort effects to investigate intergenerational differences. This study examines the birth cohort effect on morbidity burden and multimorbidity in Hong Kong community. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-023927DOI Listing
January 2019

New guidelines for DNA methylome studies regarding 5-hydroxymethylcytosine for understanding transcriptional regulation.

Genome Res 2019 Feb 19. Epub 2019 Feb 19.

The Chinese University of Hong Kong

Many DNA methylome profiling methods cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Since 5mC typically acts as a repressive mark whereas 5hmC is an intermediate form during active demethylation, the inability to separate their signals could lead to incorrect interpretation of the data. Is the extra information contained in 5hmC signals worth the additional experimental and computational costs? Here we combine whole-genome bisulfite sequencing (WGBS) and oxidative WGBS (oxWGBS) data in various human tissues to investigate the quantitative relationships between gene expression and the two forms of DNA methylation at promoters, transcript bodies, and immediate downstream regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.240036.118DOI Listing
February 2019

Circulating microRNAs: In a Class of Their Own.

Authors:
Rossa W K Chiu

Clin Chem 2019 Feb 19. Epub 2019 Feb 19.

Li Ka Shing Institute of Health Sciences and Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.301051DOI Listing
February 2019

Environmental controls on soil pH in planted forest and its response to nitrogen deposition.

Environ Res 2019 Feb 14;172:159-165. Epub 2019 Feb 14.

Department of Biology, Colorado State University, Fort Collins, CO 80523, USA. Electronic address:

Background: Soil pH is important for controlling many soil properties. The variation in soil pH can be associated with changes in climate, soil buffering system, nitrogen deposition, and plants. However, there still lacks a comprehensive study exploring the effects of all these factors on soil pH simultaneously. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.envres.2019.02.020DOI Listing
February 2019

Sirt6 deacetylase activity regulates circadian rhythms via Per2.

Biochem Biophys Res Commun 2019 Feb 16. Epub 2019 Feb 16.

Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, 518055, China; Medical Research Center, Shenzhen University Health Science Center, Shenzhen, 518055, China; Department of Biochemistry & Molecular Biology, Shenzhen University Health Science Center, Shenzhen, 518055, China. Electronic address:

Circadian clock relies on a transcription and translation feedback loop (TTFL). Two transcription factors, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.01.143DOI Listing
February 2019

Oxidation etching induced dual-signal response of carbon dots/silver nanoparticles system for ratiometric optical sensing of HO and HO-related bioanalysis.

Anal Chim Acta 2019 May 15;1055:81-89. Epub 2018 Dec 15.

Key Laboratory of Eco-Environments in Three Gorges Reservoir Region (Ministry of Education), School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. Electronic address:

Ratiometric sensing suffers from less interference and can obtain more accurate results than single-signal assay. Here, a new ratiometric optical sensing strategy for HO detection is developed by etching silver nanoparticles (AgNPs) to deactivate fluorescence resonance energy transfer (FRET) and reduce Rayleigh scattering based on a hyphenated technique of fluorescence and second-order Rayleigh scattering (SRS). The ratiometric detection of HO is achieved through exploiting a hybrid system fabricated by fluorescent carbon dots and silver nanoparticles (CDs/AgNPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2018.12.015DOI Listing

Plasmonic metal nanoparticles as efficient mass tags for ion signal amplification and ultrasensitive detection of protein markers.

Anal Chim Acta 2019 May 9;1055:1-6. Epub 2019 Jan 9.

Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong S.A.R, PR China. Electronic address:

The development of sensitive and specific analytical methods is critical for the discovery of molecular biomarkers, which assists disease diagnosis and understanding biological processes. Herein, a highly sensitive method is developed using antibody-conjugated plasmonic metal nanoparticles for the detection of targeted biomarkers down to low attomole level via coupling of immunoassay techniques with laser ionization mass spectrometry (LI-MS). The conjugated antibodies target specific antigens, while the metal nanoparticles act as mass tags and ion reservoirs for the signal amplification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.aca.2018.12.057DOI Listing

Hypothesis, analysis and synthesis, it's all Greek to me.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Bioinformatics Research Laboratory, Department of Biological Sciences, University of Cyprus, Nicosia, Cyprus.

The linguistic foundations of science and technology include many terms that have been borrowed from ancient languages. In the case of terms with origins in the Greek language, the modern meaning can often differ significantly from the original one. Here we use the PubMed database to demonstrate the prevalence of words of Greek origin in the language of modern science, and call for scientists to exercise care when coining new terms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.43514DOI Listing
February 2019

[Coagulation function and hemorrhagic diseases in preterm infants with different gestational ages].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):120-124

Department of Neonatology, Xiamen Maternal and Child Health Care Hospital, Xiamen, Fujian 361000, China.

Objective: To study the correlation between coagulation function and gestational age in preterm infants and the possible value of coagulation function measurement in predicting hemorrhagic diseases.

Methods: The clinical data of preterm infants who were hospitalized between September 2016 and August 2017 were collected. The coagulation indicators were measured within 2 hours after birth. Read More

View Article

Download full-text PDF

Source
February 2019

The Pain Catastrophizing Scale-short form: psychometric properties and threshold for identifying high-risk individuals.

Int Psychogeriatr 2019 Feb 20:1-10. Epub 2019 Feb 20.

Department of Psychiatry,North District Hospital,Hong Kong.

ABSTRACTObjective:The Pain Catastrophizing Scale (PCS) measures three aspects of catastrophic cognitions about pain-rumination, magnification, and helplessness. To facilitate assessment and clinical application, we aimed to (a) develop a short version on the basis of its factorial structure and the items' correlations with key pain-related outcomes, and (b) identify the threshold on the short form indicative of risk for depression.

Design: Cross-sectional survey. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1041610219000024DOI Listing
February 2019

Association of incident dialysis modality with mortality: a protocol for systematic review and meta-analysis of randomized controlled trials and cohort studies.

Syst Rev 2019 Feb 19;8(1):55. Epub 2019 Feb 19.

Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.

Background: At least 2.6 million adults and children receive dialysis treatment for end-stage kidney disease (ESKD) worldwide. The large majority of these receive hemodialysis (HD), while the remaining receive peritoneal dialysis (PD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13643-019-0972-1DOI Listing
February 2019

Hallux valgus among sales promotion women wearing high heels in a department store.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019828456

1 Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Background:: Wearing high heels for an extended period of time can cause several pathological conditions in women's feet, one of such is the hallux valgus (HV), as shown by a number of cross-sectional studies. This study aims to evaluate the incidence of HV among sales promotion women and to know the association of the high heel shoes with the severity of HV in that population.

Method:: This study used comparative cross-sectional design between two groups, wearing high heel and flat shoes; sales promotion women who work for at least 1 year were recruited as subjects by means of purposive sampling and were given questionnaires, and then physical and radiological examination of the foot were performed to detect any HV and its severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2309499019828456DOI Listing
February 2019

Is anterior cruciate ligament graft rupture (after successful anterior cruciate ligament reconstruction and return to sports) actually a graft failure or a re-injury?

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019829625

1 Sports Injury Centre, Department of Orthopaedics, Government Medical College Hospital, Chandigarh, India.

Purpose:: The objective of this study is to discuss the fact that whether graft rupture after successful anterior cruciate ligament (ACL) reconstruction surgery is due to graft failure or re-injury to the reconstructed ACL.

Methods:: In total, 340 sportspersons, meeting our inclusion criteria, were assessed for rupture of ipsilateral ACL graft and ACL injury of the contralateral knee. Patients with ipsilateral ACL graft rupture were labelled as group 1, while those with contralateral ACL injury were labelled as group 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2309499019829625DOI Listing
February 2019

Evaluating the risk of popliteal artery injury in the all-inside meniscus repair based on the location of posterior meniscal lesions.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019828552

Department of Orthopaedic Surgery, National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

The 'all-inside' meniscus repair is extremely useful technique in addressing tears at the far posterior horn of meniscus. However, this procedure may place the popliteal neurovascular bundle at risk of injury. The purpose of this study was to evaluate the risk of popliteal artery injury by the trajectory of anchor delivery instruments inserted through standard knee arthroscopic portals for the repair of the far posterior horn of meniscus tears. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2309499019828552DOI Listing
February 2019

Reduction in foraminal height after lateral access surgery does not affect quality of life: A 2-year outcome study on lateral lumbar interbody fusion.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019829336

Department of Orthopaedic Surgery, Singapore General Hospital, Singapore.

Introduction:: Reduction in neuroforaminal height (FH) may diminish the indirect decompression benefit that lateral access surgery (LAS) provides. However, the relationship between postoperative FH reduction in LAS and health-related quality-of-life (HRQoL) outcomes remains unclear.

Objectives:: To determine whether FH reduction affects HRQoL outcomes at 2-year follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2309499019829336DOI Listing
February 2019

The preliminary report about the modified supramalleolar tibial osteotomy for asymmetric ankle osteoarthritis.

J Orthop Surg (Hong Kong) 2019 Jan-Apr;27(1):2309499019829204

1 Department of Orthopedic Surgery, Hanyang University College of Medicine, Hanyang University Hospital, Seoul, South Korea.

Objective:: Supramalleolar tibial osteotomy (SMO) for asymmetric ankle osteoarthritis (OA) is known to lead to satisfactory. Here, authors present a preliminary report on SMO surgical treatment in patients with asymmetric ankle arthritis.

Materials And Methods:: We reviewed cases of asymmetric ankle OA treated by modified SMO between January 2011 and October 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2309499019829204DOI Listing
February 2019

Effect of Morning Exercise With or Without Breaks in Prolonged Sitting on Blood Pressure in Older Overweight/Obese Adults.

Hypertension 2019 Feb 20:HYPERTENSIONAHA11812373. Epub 2019 Feb 20.

From the School of Human Sciences (Exercise and Sport Science), University of Western Australia, Perth (M.J.W., D.W.D., L.H.N., D.J.G.).

Both exercise and breaks in prolonged sitting can reduce blood pressure (BP) in older overweight/obese adults. We investigated whether there is an additive hypotensive effect when exercise is combined with subsequent breaks in sitting. Sex differences and changes in plasma catecholamines as a potential candidate mechanism underlying BP responses were also examined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12373DOI Listing
February 2019