154,454 results match your criteria Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine[Journal]


Deriving Neural Cells from Pluripotent Stem Cells for Nanotoxicity Testing.

Methods Mol Biol 2019 ;1894:57-72

College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, USA.

Stem cells are undifferentiated biological cells that can differentiate into all lineages under defined control condition. Stem cell neuronal differentiation can faithfully recapitulate stages of neural development and generate neuronal progenitors, mature neurons, and glial cells. Stem cell technology will largely allow for the replacement of animal studies and reduce costs, and will provide a new paradigm for in toxic genomics, bioinformatics, systems biology, and epigenetics studies. Read More

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January 2019

Using Drug Expression Profiles and Machine Learning Approach for Drug Repurposing.

Methods Mol Biol 2019 ;1903:219-237

School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong.

The cost of new drug development has been increasing, and repurposing known medications for new indications serves as an important way to hasten drug discovery. One promising approach to drug repositioning is to take advantage of machine learning (ML) algorithms to learn patterns in biological data related to drugs and then link them up to the potential of treating specific diseases. Here we give an overview of the general principles and different types of ML algorithms, as well as common approaches to evaluating predictive performances, with reference to the application of ML algorithms to predict repurposing opportunities using drug expression data as features. Read More

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January 2019

Sex Pheromones of Two Leafminer Species, Antispila oinophylla and Holocacista rivillei (Lepidoptera: Heliozelidae) Infesting Grapevine in Italy.

J Chem Ecol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biology, Lund University, Sölvegatan 37, 223 62, Lund, Sweden.

Two heliozelid species, Antispila oinophylla van Nieukerken & Wagner and Holocacista rivillei (Stainton) severely infest Italian grapevines. The volatile pheromones from calling females were collected by solid phase micro extraction (SPME) and analyzed by gas chromatography with electroantennographic detection (GC-EAD). Two compounds from A. Read More

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December 2018

Optimizing the removal of nitrate from aqueous solutions via reduced graphite oxide-supported nZVI: synthesis, characterization, kinetics, and reduction mechanism.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Civil and Environment Engineering, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.

Graphene has been considered an ideal absorbent and excellent carrier for nanoparticles. Reduced graphite oxide (rGO)-supported nanoscale zero-valent iron (nZVI@rGO) is an effective material for removing nitrate from water. nZVI@rGO nanocomposites were prepared by a liquid-phase reduction method and then applied for nitrate-nitrogen (NO-N) removal in aqueous solution under anaerobic conditions. Read More

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December 2018

Age as a Moderator of Social Skills Intervention Response Among Korean Adolescents with Autism Spectrum Disorder.

J Autism Dev Disord 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychiatry, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, South Korea.

Few studies have investigated the effect of age on treatment effectiveness of evidence-based social skills training in autism spectrum disorder (ASD) adolescents. This study evaluated the effectiveness of Program for the Education and Enrichment of Relational Skills (PEERS) in different ages of ASD adolescents. A total of 110 ASD adolescents aged 11-19 years were divided into early, middle, and late adolescence groups, and the changes in outcome measures following intervention were compared among the three groups. Read More

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December 2018

Enhancing tetrandrine cytotoxicity in human lung carcinoma A549 cells by suppressing mitochondrial ATP production.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 13. Epub 2018 Dec 13.

Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.

ATP depletion induced by inhibiting glycolysis or mitochondrial ATP production has been demonstrated to cause cancer cell death. Whether ATP depletion can enhance the efficacy and potency of anti-cancer effects of herbal compounds is so far unknown. We examined the enhancing effect of ATP depletion on anti-cancer actions of tetrandrine (TET) in human lung carcinoma A549 cells. Read More

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December 2018

Comparison of percutaneous endoscopic lumbar discectomy versus microendoscopic discectomy for the treatment of lumbar disc herniation: a meta-analysis.

Int Orthop 2018 Dec 13. Epub 2018 Dec 13.

Spine Surgery Center, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao, Nanjing, 210009, Jiangsu, China.

Purpose: We conducted a systematic review and meta-analysis to compare the clinical outcomes of percutaneous endoscopic lumbar discectomy (PELD) and microendoscopic discectomy (MED) for the treatment of lumbar disc herniation (LDH), and to clarify whether PELD is more superior to MED.

Methods: We performed a comprehensive search in the databases of MEDLINE, EMBASE, PubMed, Web of Science, Cochrane database, CNKI, and Wanfang Data to acquire all relevant studies up to July 2018. The searched literatures were then screened according to the strict inclusion and exclusion criteria. Read More

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December 2018

Hepatic steatosis and reduction in steatosis following bariatric weight loss surgery differs between segments and lobes.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Liver Imaging Group, Department of Radiology, University of California San Diego, 200 W. Arbor Drive #8756, San Diego, CA, 92103-8756, USA.

Objectives: The purpose of this study was to (1) evaluate proton density fat fraction (PDFF) distribution across liver segments at baseline and (2) compare longitudinal segmental PDFF changes across time points in adult patients undergoing a very low-calorie diet (VLCD) and subsequent bariatric weight loss surgery (WLS).

Methods: We performed a secondary analysis of data from 118 morbidly obese adult patients enrolled in a VLCD-WLS program. PDFF was estimated using magnitude-based confounder-corrected chemical-shift-encoded (CSE) MRI in each hepatic segment and lobe at baseline (visit 1), after completion of VLCD (visit 2), and at 1, 3, and 6 months (visits 3-5) following WLS. Read More

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December 2018

Improving NanoCluster Beacon performance by blocking the unlabeled NC probes.

Chem Commun (Camb) 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, USA. and Texas Materials Institute, University of Texas at Austin, Austin, Texas 78712, USA.

While NanoCluster Beacon (NCB) is a versatile molecular probe, it suffers from a low target-specific signal issue due to impurities. Here we show that adding a "blocker" strand to the reaction can effectively block the nonfunctional probes and enhance the target-specific signal by 14 fold at a 0.1 target/probe ratio. Read More

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December 2018

Editorial on "Can navigation-assisted surgery help achieve negative margins in resection of pelvic and sacral tumor?"

J Spine Surg 2018 Sep;4(3):681-683

Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.

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September 2018

Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity.

Mol Ther Methods Clin Dev 2018 Dec 25;11:143-154. Epub 2018 Oct 25.

Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA.

Gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. However, activation of proto-oncogenes via insertional mutagenesis has resulted in the development of leukemia. We have utilized cellular bar coding to investigate the impact of different vector designs on the clonal behavior of hematopoietic stem and progenitor cells (HSPCs) during expansion, as a quantitative surrogate assay for genotoxicity in a non-human primate model with high relevance for human biology. Read More

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December 2018

A Rare Pathological Couplet of Colocolic Intussusception Plus Cecal Bascule in a Young Adult: A Case Report.

Cureus 2018 Oct 9;10(10):e3430. Epub 2018 Oct 9.

Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, AUS.

This report is of a rare case involving a 27-year-old female who presented to the hospital with the pathological couplet of colocolic intussusception and cecal bascule causing bowel obstruction. Up to the time of presentation to the hospital, this patient had not undergone a full investigation for a known iron deficiency, anemia. Subsequently, during the emergency admission and after having an operative surgical procedure, the patient was found to have both a congenitally malpositioned cecum and a benign colonic polyp-forming condition. Read More

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October 2018

Virotherapy-recruited PMN-MDSC infiltration of mesothelioma blocks antitumor CTL by IL-10-mediated dendritic cell suppression.

Oncoimmunology 2019 16;8(1):e1518672. Epub 2018 Oct 16.

AIDS Institute and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China.

Antitumor cytotoxic T lymphocytes (CTLs) are essential for immune surveillance, yet the blockade of eliciting such CTLs during oncolytic virotherapy remains incompletely understood. Here, we show that oncolysis of mesothelioma by modified vaccinia Tiantan (MVTT) induces damage-associated molecular patterns exposure. Although MVTT leads to regression of established mesothelioma dose-dependently, antitumor CTLs are rarely induced. Read More

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October 2018

DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells.

Oncoimmunology 2019 2;8(1):e1509173. Epub 2018 Nov 2.

Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

Chimeric antigen receptor (CAR) T cell immunotherapies have shown remarkable efficacy in treating multiple types of hematological malignancies but are not sufficiently effective at treating solid tumors. NKG2D is a strong activating receptor for NK cells and a co-stimulatory receptor for T cells. NKG2D signal transduction depends on DNAX-activating protein 10 (DAP10). Read More

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November 2018

A Rare Case of Laryngopyocele with Airway Obstruction.

J Clin Imaging Sci 2018 15;8:42. Epub 2018 Nov 15.

Department of Radiology, Tuen Mun Hospital, Tuen Mun, Hong Kong.

Laryngocele is a rare entity and can be defined as an abnormal cystic dilatation of saccule of the laryngeal ventricle with communication to the lumen of larynx. Laryngopyocele is a rare complication of laryngocele when it is infected. Patients may present with fever, neck swelling, shortness of breath, and hoarseness. Read More

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November 2018

Mesoporous silica-based nanoplatforms for the delivery of photodynamic therapy agents.

J Pharm Investig 2018 9;48(1):3-17. Epub 2017 Sep 9.

Biomarker Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 10408 Republic of Korea.

Photodynamic therapy (PDT) is an established method for the treatment of cancer which utilizes light, a photosensitizer (PS), and oxygen. Unfavourable characteristics of most PSs, such as low solubility and tumour specificity have led many researchers to adopt nanoscale drug delivery platforms for use in PDT. Mesoporous silica nanoparticles (MSNs) form a significant part of that effort, due to their ease and controllability of synthesis, ease of loading, availability of diverse surface functionalization, and biocompatibility. Read More

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September 2017

Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma.

Oncotarget 2018 Nov 8;9(90):36057-36066. Epub 2017 Dec 8.

Beijing 302 Hospital, Beijing, 100039, China.

Hepatocellular carcinoma (HCC) is the most common neoplasm and is a leading cause of cancer-related death. Despite advances in the diagnosis and management of HCC, its prognosis remain unfavorable. Accumulating evidence has shown that long intergenic noncoding RNAs (lincRNAs) play central roles in the development of HCC. Read More

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November 2018

Efficacy of First-Line Targeted Therapy in Real-World Korean Patients with Metastatic Renal Cell Carcinoma: Focus on Sunitinib and Pazopanib.

J Korean Med Sci 2018 Dec 22;33(51):e325. Epub 2018 Nov 22.

Department of Urology, National Cancer Center, Goyang, Korea.

Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice.

Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. Read More

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December 2018

Complete Recovery of Oxysterol 7α-Hydroxylase Deficiency by Living Donor Transplantation in a 4-Month-Old Infant: the First Korean Case Report and Literature Review.

J Korean Med Sci 2018 Dec 22;33(51):e324. Epub 2018 Nov 22.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of a 3-month-old boy with progressive cholestatic hepatitis and severe hepatic fibrosis. Read More

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December 2018

An automated bacterial concentration and recovery system for pre-enrichment required in rapid Escherichia coli detection.

Sci Rep 2018 Dec 13;8(1):17808. Epub 2018 Dec 13.

Jiangsu Delin Environmental Protection Technology Co., Ltd., Jiangsu, China.

One of the biggest challenges in rapid low concentration bacterial detection is the pre-concentration or pre-enrichment, which aims to increase bacteria concentration and reduce sample volume for easy bacterial detection. In practical bacterial detection, large-volume water samples with a pathogenic bacterial concentration of less than 1 CFU/mL have to be tested rapidly. The reported biosensors either have insufficient detection limit or have limited capability of handling a sufficiently large water sample. Read More

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December 2018

Active Acupoints Differ from Inactive Acupoints in Modulating Key Plasmatic Metabolites of Hypertension: A Targeted Metabolomics Study.

Sci Rep 2018 Dec 13;8(1):17824. Epub 2018 Dec 13.

College of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, 37 Shierqiao Road, Jinniu Street, Chengdu, 610075, Sichuan, China.

The effect of active acupoints versus inactive acupoints in treating hypertension is not well documented. Metabolic phenotypes, depicted by metabolomics analysis, reflect the influence of external exposures, nutrition, and lifestyle on the integrated system of the human body. Therefore, we utilized high-performance liquid chromatography tandem mass spectrometry to compare the targeted metabolic phenotype changes induced by two different acupoint treatments. Read More

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December 2018
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RSL Class Ⅱ Transcription Factors Guide the Nuclear Localization of RHL1 to Regulate Root Hair Development.

Plant Physiol 2018 Dec 13. Epub 2018 Dec 13.

Kyung Hee University CITY: Yongin STATE: Gyeonggi-do POSTAL_CODE: 17104 Korea (South), Republic Of

Root hairs are important for absorption of nutrients and water from the rhizosphere. The ROOT HAIR DEFECTIVE-SIX LIKE (RSL) Class Ⅱ family of transcription factors is expressed preferentially in root hairs and has a conserved role in root hair development in land plants. We functionally characterized the seven members of the RSL Class II subfamily in the rice (Oryza sativa) genome. Read More

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December 2018

Wake-up call from Hong Kong.

Science 2018 Dec;362(6420):1215

Chunli Bai is president of the Chinese Academy of Sciences.

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December 2018

Comparison of DNA fragmentation levels in spermatozoa with different sex chromosome complements.

Reprod Biomed Online 2018 Nov 20. Epub 2018 Nov 20.

Assisted Conception Unit, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, 1E, Special Block, Prince of Wales Hospital, Ngan Shing Street, Hong Kong. Electronic address:

Research Question: Do spermatozoa with different sex chromosome complements (X and Y; aneuploidy and monosomy) exhibit different degrees of DNA damage?

Design: A prospective, observational study to measure the DNA fragmentation level and sex chromosome complement simultaneously using combined sperm chromosome dispersion (SCD) and fluorescence in-situ hybridization tests. Two methods were used to evaluate SCD images: a traditional semi-quantitative method to categorize halo size and a newly developed quantitative method based on the Matlab image analysis programme to more precisely measure the halo area and calculate the halo size index (HSI).

Results: The HSI (which was inversely proportional to DNA fragmentation level) of Y chromosome-bearing spermatozoa was significantly (P < 0. Read More

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November 2018

Anticipatory pleasure for future rewards is attenuated in patients with schizophrenia but not in individuals with schizotypal traits.

Schizophr Res 2018 Dec 10. Epub 2018 Dec 10.

Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China; School of Applied Psychology and Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia. Electronic address:

The anhedonia paradox is consistently observed in individuals with schizophrenia. However, the underlying mechanism of the dissociation between trait and state hedonic capacity remains unclear. In the present study, we aimed to re-examine anhedonia in patients with schizophrenia (SCZ) and individuals with high schizotypy (HS) using the Monetary Incentive Delay (MID) task to assess different dimensions of anticipatory and consummatory pleasure. Read More

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December 2018

Measurement of vascularity in the scar: A systematic review.

Burns 2018 Dec 10. Epub 2018 Dec 10.

Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Hong Kong. Electronic address:

Background: Vascularity is an important parameter closely associated with the scar maturation. Reliable and accurate measurement of vascularity helps to monitor the scar change and adopt targeted interventions to prevent excessive scarring and achieve promising outcomes. However, there is no consensus on the assessment tools for the vascularity measurement in scars. Read More

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December 2018

Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Surgery and chemotherapy are the gold-standard treatments for ovarian cancer. The major cause of treatment failure in patients with ovarian cancer is tumoral heterogeneity and drug resistance. Paclitaxel (PTX) is one of the most commonly used first-line drugs for ovarian cancer chemotherapy. Read More

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December 2018

Copy number variation profile in noninvasive prenatal testing (NIPT) can identify co-existing maternal malignancies: Case reports and a literature review.

Taiwan J Obstet Gynecol 2018 Dec;57(6):871-877

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University School of Medicine, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Objective: The coexistence of maternal malignancy and pregnancy has received increasing attention in Noninvasive prenatal testing (NIPT) studies. Malignancy in pregnant women potentially affects the copy number variation (CNV) profile in NIPT results. Only one case of hematologic cancer has been reported in a Hong-Kong pregnant women, and solid tumors have never been reported in pregnant Chinese women. Read More

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December 2018

Knowledge, perceptions, and clinical experiences on molar incisor hypomineralization among dental care providers in Hong Kong.

BMC Oral Health 2018 Dec 13;18(1):217. Epub 2018 Dec 13.

Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong, SAR, China.

Background: Molar incisor hypomineralization (MIH) is an alarming problem with considerable challenges in management. This study aimed to evaluate and compare the knowledge, perceptions, and clinical experiences of molar incisor hypomineralization (MIH) between general dental practitioners (GDPs) and paediatric dentists (PDs) in Hong Kong.

Methods: A cross-sectional survey of 557 randomly selected GDPs (approximately 25% of all registered dentists) and all registered PDs (n = 31) were invited. Read More

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December 2018

Comparative genomic analysis revealed rapid differentiation in the pathogenicity-related gene repertoires between Pyricularia oryzae and Pyricularia penniseti isolated from a Pennisetum grass.

BMC Genomics 2018 Dec 13;19(1):927. Epub 2018 Dec 13.

State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

Background: A number of Pyricularia species are known to infect different grass species. In the case of Pyricularia oryzae (syn. Magnaporthe oryzae), distinct populations are known to be adapted to a wide variety of grass hosts, including rice, wheat and many other grasses. Read More

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December 2018

Building Sustainable Supply Chains for Organizations Based on QFD: A Case Study.

Int J Environ Res Public Health 2018 Dec 12;15(12). Epub 2018 Dec 12.

International Business School, Shanghai University of International Business and Economics, Shanghai 201620, China.

Environmental protection has been increasingly emphasized by stakeholders, including social organizations, the government, and the public. As a result, building a sustainable supply chain has now become a part of social corporate responsibility as well as a challenge for firms, including small and medium-sized enterprises (SMEs). Taking a chemical enterprise (called enterprise C, in this paper) as an example, this paper uses quality function deployment (QFD) techniques and sets up a house of quality (HOQ) to investigate how a SME can achieve sustainable supply chain management. Read More

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December 2018

Applied Stress-Assisted Growth of Single Crystal γ-Fe₂O₃ Nanowires.

Nanomaterials (Basel) 2018 Dec 12;8(12). Epub 2018 Dec 12.

Bejing Key Laboratory of Quantum Devices, Key Laboratory for the Physics and Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, China.

It is difficult to obtain γ-Fe₂O₃ nanostructures by heating iron substrate in ambient conditions because γ-Fe₂O₃ is less thermodynamically stable than α-Fe₂O₃. In this work, we synthesize γ-Fe₂O₃ nanowires by heating iron particles under an external force. The stacking style of iron and oxygen ions under a strong shearing stress tends to adopt the γ-Fe₂O₃ structure regardless of the thermodynamic restriction. Read More

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December 2018

Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein⁻Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers.

Cancers (Basel) 2018 Dec 11;10(12). Epub 2018 Dec 11.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.

Pharmaceutical reactivation of lytic cycle of Epstein⁻Barr virus (EBV) represents a potential therapeutic strategy against EBV-associated epithelial malignancies, e.g., gastric carcinoma (GC) and nasopharyngeal carcinoma (NPC). Read More

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December 2018

Shear-Assisted Laser Transfer of Metal Nanoparticle Ink to an Elastomer Substrate.

Materials (Basel) 2018 Dec 11;11(12). Epub 2018 Dec 11.

Optical Nanoprocessing Lab, Department of Mechanical Engineering, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Gyeonggi-do 15588, Korea.

Selective laser sintering of metal nanoparticle ink is an attractive technology for the creation of metal layers at the microscale without any vacuum deposition process, yet its application to elastomer substrates has remained a highly challenging task. To address this issue, we introduced the shear-assisted laser transfer of metal nanoparticle ink by utilizing the difference in thermal expansion coefficients between the elastomer and the target metal electrode. The laser was focused and scanned across the absorbing metal nanoparticle ink layer that was in conformal contact with the elastomer with a high thermal expansion coefficient. Read More

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December 2018

The Effects of Mind-Body Exercise on Cognitive Performance in Elderly: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2018 Dec 9;15(12). Epub 2018 Dec 9.

Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul 08826, Korea.

: As the situation of cognitive aging is getting worse, preventing or treating cognitive decline through effective strategies is highly important. This systematic review aims to investigate whether mind-body exercise is an effective approach for treating cognition decline. : Searches for the potential studies were performed on the eight electronic databases (MEDLINE, Scopus, Web of Science, SPORTDiscus, CINAHL, PsycArtilces, CNKI, and Wanfang). Read More

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December 2018

Chemical Profiling of with High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry (HPLC/Q-TOF MS) Reveals Absence of Lobeline in the Herb.

Molecules 2018 Dec 10;23(12). Epub 2018 Dec 10.

Department of Biomedical Sciences, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China.

is a kind of herbal medicine widely distributed and used in Asia. The chemical components of this herb, however, have not been well studied until now. Lobeline, as an essential and famous bioactive compound in genus, has been assumed to be present in . Read More

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December 2018

Relationships between Meteorological Parameters and Particulate Matter in Mae Hong Son Province, Thailand.

Int J Environ Res Public Health 2018 Dec 10;15(12). Epub 2018 Dec 10.

Department of Social and Environmental Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Meteorological parameters play an important role in determining the prevalence of ambient particulate matter (PM) in the upper north of Thailand. Mae Hong Son is a province located in this region and which borders Myanmar. This study aimed to determine the relationships between meteorological parameters and ambient concentrations of particulate matter less than 10 µm in diameter (PM) in Mae Hong Son. Read More

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December 2018

Quantifying Short-Term Urban Land Cover Change with Time Series Landsat Data: A Comparison of Four Different Cities.

Sensors (Basel) 2018 Dec 7;18(12). Epub 2018 Dec 7.

School of Computer Science, South China Normal University, Guangzhou 510631, China.

Short-term characteristics of urban land cover change have been observed and reported from satellite images, although urban landscapes are mainly influenced by anthropogenic factors. These short-term changes in urban areas are caused by rapid urbanization, seasonal climate changes, and phenological ecological changes. Quantifying and understanding these short-term characteristics of changes in various land cover types is important for numerous urban studies, such as urbanization assessments and management. Read More

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December 2018

Nutrition, Energy Expenditure, Dysphagia, and Self-Efficacy in Stroke Rehabilitation: A Review of the Literature.

Brain Sci 2018 Dec 7;8(12). Epub 2018 Dec 7.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

While significant research has been performed regarding the use of thrombolytic agents and thrombectomy in the setting of acute stroke, other factors, such as nutritional status of stroke patients, is a less explored topic. The topic of nutrition is critical to the discussion of stroke, as up to half of stroke survivors may be considered malnourished at discharge. Dysphagia, old age, restricted upper limb movement, visuospatial impairment, and depression are all important risk factors for malnutrition in this cohort. Read More

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December 2018

The Comorbidity of Gambling Disorder among Macao Adult Residents and the Moderating Role of Resilience and Life Purpose.

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

Department of Psychology, Faculty of Social Sciences, University of Macau, Avenida da Universidade, Taipa, Macao, China.

Macao, China's only city with legalized casinos, has maintained a high prevalence of gambling participation and gambling disorder (GD) over the past decade. The mental health risks associated with such high levels have been overlooked. In order to estimate the comorbid prevalence of GD with depression, anxiety, and Internet gaming disorder (IGD) and to explore the potential buffering effect of psychological resilience and purpose in life, this study obtained a representative adult Chinese sample ( = 1000, 44% male, aged 18⁻97 years) from a telephone survey conducted between October and November of 2016. Read More

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December 2018

Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer's Disease.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Department of Rehabilitation Science, Graduate School of Inje University, Gimhae 50834, Korea.

Irisin, a skeletal muscle-secreted myokine, produced in response to physical exercise, has protective functions in both the central and the peripheral nervous systems, including the regulation of brain-derived neurotrophic factors. In particular, irisin is capable of protecting hippocampus. Since this area is the region of the brain that is most susceptible to Alzheimer's disease (AD), such beneficial effect may inhibit or delay the emergence of neurodegenerative diseases, including AD. Read More

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December 2018

The Effects of Tai Chi on Heart Rate Variability in Older Chinese Individuals with Depression.

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

Department of Martial Arts, Shanghai University of Sport, Shanghai 200438, China.

Very little research has been done to simultaneously investigate the effects of Tai Chi (TC) on depression and heart rate variability (HRV). This study, therefore, attempted to explore the effects of TC on depression and on HRV parameters. Sixty older individuals with depression score of 10 or above (the Geriatric Depression Scale, GDS) were randomly assigned into two groups: TC ( = 30) and control group ( = 30). Read More

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December 2018

Ambient air pollution in gastrointestinal endoscopy unit; rationale and design of a prospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13600

Department of Internal Medicine.

Background: A gastrointestinal endoscopy unit is frequently exposed to gastrointestinal gas expelled from patients and electrocoagulated tissue through carbonation for the treatment of gastrointestinal neoplasms or hemostasis of gastrointestinal bleeding. This can be potentially harmful to the health of not only the healthcare personnel but also patients who undergo endoscopic examinations. However, there has been scarce data on air quality in the endoscopy unit. Read More

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December 2018

A long time radiological follow-up of neuronal intranuclear inclusion disease: Two case reports.

Medicine (Baltimore) 2018 Dec;97(49):e13544

Department of Radiology, The First Affiliated Hospital, Nanchang University.

Rationale: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease identified with diffusion-weighted imaging (DWI) high-intensity signal in magnetic resonance imaging (MRI). The disappearance of the abnormal signal is extremely rare.

Patient Concerns: We present the 2 cases of patients, both of them were suffering from heterogeneous symptoms. Read More

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December 2018

Risk factor of benign paroxysmal positional vertigo in trauma patients: A retrospective analysis using Korean trauma database.

Medicine (Baltimore) 2018 Dec;97(49):e13150

Department of Trauma Surgery, Ujeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Benign paroxysmal positional vertigo (BPPV) is a comorbid condition prevalent in patients recovering from trauma. Due to the paucity of studies investigating the etiology of this condition, the present study sought to analyze the high-risk group of BPPV patients following trauma.Trauma patients visiting the emergency department from January to December 2016 were enrolled. Read More

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December 2018

High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations.

Brain 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Brain and spinal arteriovenous malformations are congenital lesions causing intracranial haemorrhage or permanent disability especially in young people. We investigated whether the vast majority or all brain and spinal arteriovenous malformations are associated with detectable tumour-related somatic mutations. In a cohort of 31 patients (21 with brain and 10 with spinal arteriovenous malformations), tissue and paired blood samples were analysed with ultradeep next generation sequencing of a panel of 422 common tumour genes to identify the somatic mutations. Read More

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December 2018

Increased Mortality Associated with Higher Pre-Dialysis Serum Sodium Variability: Results of the International MONitoring Dialysis Outcome Initiative.

Am J Nephrol 2018 Dec 13;49(1):1-10. Epub 2018 Dec 13.

Renal Research Institute, New York, New York, USA.

Background: Low serum sodium (SNa) is associated with an increased mortality in chronic hemodialysis (HD) patients. Dialysis patients are thought to have an individual pre-dialysis SNa set-point, yet there is evidence for variability of pre-dialysis SNa in individual patient. In this study, we explored the association of several SNa variability metrics with all-cause mortality in a large patient population from the international MONitoring Dialysis Outcomes (MONDO) Initiative. Read More

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December 2018

Prostitute homicides: A 37-year exploratory study of the offender, victim, and offense characteristics.

Forensic Sci Int 2018 Nov 30;294:196-203. Epub 2018 Nov 30.

School of Criminology, Simon Fraser University, Burnaby, BC, Canada.

Research demonstrates that prostitutes are at heightened risk of fatal victimization. Besides, prostitute homicides are known to be notoriously difficult to investigate; and hence, little is known about this underresearched offender and vulnerable victim populations. This study aims to explore the offender, victim, and offense characteristics of 244 single-victim heterosexual prostitute homicides, extracted from the US Supplementary Homicide Reports database, for a period spanning over 37years (1976-2012). Read More

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November 2018

Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway.

Biomaterials 2018 Nov 30;192:569-578. Epub 2018 Nov 30.

Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, PA, 15261, USA; The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Mesenchymal stem cells (MSCs) represent a promising cell source to regenerate articular cartilage, but current chondroinduction protocols, commonly using transforming growth factor-β (TGFβ), lead to concomitant chondrocytic hypertrophy with ossification risk. Here, we showed that a 14-day culture of MSC-laden hyaluronic acid hydrogel in the presence of TGFβ, followed by 7 days culture in TGFβ-free medium, with the supplement of Wnt/β-catenin inhibitor XAV939 from day 10-21, resulted in significantly reduced hypertrophy phenotype. The stability of the hyaline phenotype of the MSC-derived cartilage, generated with a standard protocol (Control) or the optimized (Optimized) method developed in this study, was further examined through intramuscular implantation in nude mice. Read More

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November 2018

A novel electrochemical modification combined with one-step pyrolysis for preparation of sustainable thorn-like iron-based biochar composites.

Bioresour Technol 2018 Oct 22;274:379-385. Epub 2018 Oct 22.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China. Electronic address:

A novel method incorporating electrochemical (EC) modification and one-step pyrolysis is developed to prepare sustainable FeO-based magnetic adsorbent (EC-FeO/BC) via pyrolysis of FeCl-pretreated corn straw-derived biochar under an electric field generated by graphite electrode. Morphological characterization revealed a uniform dispersion of rod-like crystalline FeO nanoparticles in the inner and outer structure of biochar. The EC modification also introduced more oxygen-containing functional groups, which contributed to an outstanding Pb adsorption capacity (113 mg g) and fast kinetics (0. Read More

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October 2018