17,462,277 results match your criteria Homo Journal of Comparative Human Biology [Journal]

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Predictable Electronic Tuning By Choice of Azine Substituent in Five Iron(II) Triazoles: Redox Properties and DFT Calculations.

Chem Asian J 2018 Dec 14. Epub 2018 Dec 14.

University of Otago, Chemistry, Union Place West, 9054, Dunedin , NEW ZEALAND.

Five new mononuclear iron(II) tris-ligand complexes, and four solvatomorphs, have been made from the azine-substituted 1,2,4-triazole ligands (Lazine): [FeII(Lpyridazine)3](BF4)2 (1), [FeII(Lpyrazine)3](BF4)2 (2), [FeII(Lpyridine)3](BF4)2 (3), [FeII(L2pyrimidine)3](BF4)2 (4), and [FeII(L4pyrimidine)3](BF4)2 (5). Single-crystal XRD and solid-state magnetometry reveal that all of them are low spin (LS) Fe(II), except for solvatomorph 5·4H2O. Evans method NMR studies in CD2Cl2, (CD3)2CO and CD3CN show that all are LS in these solvents, except 5 in CD2Cl2 (consistent with L4pyrimidine imposing the weakest field). Read More

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December 2018

[The becoming of reactions of lipolysis in phylogenesis. The palmitic and oleic triglycerides as substrates. Insulin, condition of normolipemia and formation of hyper lipoproteinemia type IIb, IV and V].

Klin Lab Diagn 2018 ;63(1):4-15

The Federal state budget scientifc institution "The research institute of general pathology and pathophysiology" of the Russian academy of sciences, 125315, Moscow, Russia.

According to phylogenetic theory of general pathology, when living in ocean all were carnivorous (piscivorous) fatty acids transferring to cells in form of non-polar triglycerides nitially began apoB-48 chylomicrons, continued lipoproteins of very low and low density and fnalized its apoB-100 endocytosis. The fatty acids are transferred by chylomicrons + lipoproteins of very low density + lipoproteins of low density and non-polar triglycerides are hydrolyzed by hepatic glycerolhydrogenase and co-enzyme apoC-III; according WHO classifcation, hyperlipoproteinemia corresponds to type V. On land, in herbivorous who are not yet synthesized insulin, apoB-48 and chylomicrons left process of non-polar triglycerides transferring. Read More

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January 2018
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Polyelemental Nanolithography via Plasma Ion Bombardment: From Fabrication to Superior H Sensing Application.

Adv Mater 2018 Dec 14:e1805343. Epub 2018 Dec 14.

Department of Chemical and Biomolecular Engineering (BK-21 Plus), Korea Advanced Institute of Science and Technology (KAIST), Yuseong-gu, Daejeon, 34141, Republic of Korea.

The development of complex nanostructures containing a homo- and heteromixture of two or more metals is a considerable challenge in nanotechnology. However, previous approaches are considerably limited to the number of combinations of metals depending on the compatibility of elements, and to the complex shape control of the nanostructure. In this study, a significant step is taken toward resolving these limitations via the utilization of a low-energy argon-ion bombardment. Read More

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December 2018

No Lanthanides-based Catalysis in Eukaryotes.

IUBMB Life 2018 Dec 13. Epub 2018 Dec 13.

Interdepartmental Laboratory for Electron Microscopy, Roma Tre University, Roma, Italy.

In the "Hypothesis" paper entitled "Lanthanides-Based Catalysis in Eukaryotes" (IUBMB Life 2018 Nov;70(11):1067-1075), we analyzed the possibility that Ce -dependent methanol dehydrogenases (MDHs) could be found not only in archaea and bacteria but also in eukaryotic organisms. This hypothesis was based on the observation that MDHs protein sequences carrying the signature of Ce -based active sites could be found in genome-derived proteomes of the eukaryotes Plasmodium yoelii yoelii, Nephila clavipes, Hyalella azteca, Pantholops hodgsonii, and Homo sapiens. Data were analyzed following standard procedures employed in the study of phylogenetic relationships among members of protein families and their occurrence in diverse organisms. Read More

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December 2018

Trabecular bone structure in the distal femur of humans, apes, and baboons.

Anat Rec (Hoboken) 2018 Dec 12. Epub 2018 Dec 12.

Department of Anthropology, Pennsylvania State University, University Park PA 16801.

Trabecular bone structure has been used to investigate the relationship between skeletal form and locomotor behavior on the premise that trabecular bone remodels in response to loading during an animal's lifetime. The aim of this study is to characterize human distal femoral trabecular bone structure in comparison to three non-human primate taxa and relate the patterns of trabecular structural variation in the distal femur to knee posture during habitual locomotor behavior. A whole-epiphysis approach was applied using microCT scans of the distal femora of extant Homo sapiens, Pan troglodytes, Pongo pygmaeus, and Papio spp. Read More

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December 2018

Ca-Sensor Neurocalcin δ and Hormone ANF Modulate ANF-RGC Activity by Diverse Pathways: Role of the Signaling Helix Domain.

Front Mol Neurosci 2018 27;11:430. Epub 2018 Nov 27.

Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA, United States.

Prototype member of the membrane guanylate cyclase family, ANF-RGC (Atrial Natriuretic Factor Receptor Guanylate Cyclase), is the physiological signal transducer of two most hypotensive hormones ANF and BNP, and of the intracellular free Ca. Both the hormonal and the Ca-modulated signals operate through a common second messenger, cyclic GMP; yet, their operational modes are divergent. The hormonal pathways originate at the extracellular domain of the guanylate cyclase; and through a cascade of structural changes in its successive domains activate the C-terminal catalytic domain (CCD). Read More

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November 2018

Rational design of a boron-dipyrromethene-based fluorescent probe for detecting Pd sensitively and selectively in aqueous media.

Analyst 2018 Dec 13. Epub 2018 Dec 13.

State Key Laboratory of Environment-Friendly Energy Materials, School of Material Science and Engineering, and National Engineering Technology Center for Insulation Materials, Southwest University of Science and Technology, Mianyang, 621010, P. R. China.

A novel fluorescent probe for Pd2+ based on the BODIPY fluorophore exploiting the PET (Photoinduced Electron Transfer) mechanism was designed and successfully synthesized. The fluorescent probe 1 was prepared by introducing m-bisimidazolylbenzene which was connected by phenyl acetylene to the BODIPY dye at the meso position. It exhibited a rapid response and high sensitivity and selectivity toward Pd2+. Read More

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December 2018

Facile insertion of ethylene into a group 14 element-carbon bond: effects of the HOMO-LUMO energy gap on reactivity.

Chem Commun (Camb) 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, USA.

The diarylstannylenes, Sn(AriPr4)2 and Sn(AriPr6)2, (AriPr4 = C6H3-2,6-(C6H3-2,6-iPr2)2, AriPr6 = C6H3-2,6-(C6H2-2,4,6-iPr3)2), undergo a facile migratory insertion reaction with ethylene at 60 °C to afford the alkyl aryl stannylenes AriPr4SnCH2CH2AriPr4 and AriPr6SnCH2CH2AriPr6 which were characterized via 1H, 13C and 119Sn NMR, UV-vis and IR spectroscopy, as well as by X-ray crystallography. Quantum mechanical calculations were performed, and two potential mechanisms were identified, with a migratory insertion reaction pathyway being energetically preferred. Read More

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December 2018

Dissolution and homogeneous photocatalysis of polymeric carbon nitride.

Chem Sci 2018 Nov 2;9(41):7912-7915. Epub 2018 Oct 2.

Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device , Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research , School of Chemistry and Chemical Engineering , Medical School , Southeast University , Nanjing 211189 , China . Email:

As a metal-free conjugated polymer, carbon nitride (CN) has attracted tremendous attention as a heterogeneous (photo)catalyst. By following the example of enzymes, making all of the catalytic sites accessible homogeneous reactions is a promising approach toward maximizing CN activity, but hindered due to the poor solubility of CN. Herein, we report the dissolution of CN in environmentally friendly methanesulfonic acid, and homogeneous photocatalysis (two biomimetic/pharmaceutical photocatalytic oxidation reactions) driven by CN for the first time with the activity boosted up to 10-times compared to the heterogeneous counterparts. Read More

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November 2018

Identification and characterization of the causative triatomine bugs of anaphylactic shock in Zhanjiang, China.

Infect Dis Poverty 2018 Dec 11;7(1):127. Epub 2018 Dec 11.

Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China.

Background: Two health concerns primarily related to triatomine bugs are transmission of Trypanosoma cruzi through infective feces, and allergic reactions induced by triatomine bites. In the Southwestern United States, reduviid bugs bites commonly cause insect allergy. In South China, four cases of anaphylactic shock have been reported after this bite exposure. Read More

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December 2018

Human nitrobindin: the first example of an all-β-barrel ferric heme-protein that catalyzes peroxynitrite detoxification.

FEBS Open Bio 2018 Dec 9;8(12):2002-2010. Epub 2018 Nov 9.

Interdepartmental Laboratory for Electron Microscopy Roma Tre University Italy.

Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to , display an all-β-barrel structural organization. Human Nb has been described as a domain of the nuclear protein named THAP4, whose physiological function is still unknown. We report the first evidence of the heme-Fe(III)-based detoxification of peroxynitrite by the all-β-barrel -terminal Nb-like domain of THAP4. Read More

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December 2018

Factors Controlling the Diels-Alder Reactivity of Hetero-1,3-Butadienes.

ChemistryOpen 2018 Dec 26;7(12):995-1004. Epub 2018 Nov 26.

Department of Theoretical Chemistry, Amsterdam Center for Multiscale Modeling (ACMM) Vrije Universiteit Amsterdam De Boelelaan 1083 1081 HV Amsterdam The Netherlands.

We have quantum chemically explored the Diels-Alder reactivities of a systematic series of hetero-1,3-butadienes with ethylene by using density functional theory at the BP86/TZ2P level. Activation strain analyses provided physical insight into the factors controlling the relative cycloaddition reactivity of aza- and oxa-1,3-butadienes. We find that dienes with a terminal heteroatom, such as 2-propen-1-imine ( or acrolein (, are less reactive than the archetypal 1,3-butadiene (), primarily owing to weaker orbital interactions between the more electronegative heteroatoms with ethylene. Read More

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December 2018

CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs.

Front Immunol 2018 15;9:2618. Epub 2018 Nov 15.

Departamento de Inmunologia and Inmunoterapia, Centro de Investigación Medica Aplicada, Universidad de Navarra, Pamplona, Spain.

CD137 (4-1BB, Tnsfr9) is a member of the TNF-receptor (TNFR) superfamily without known intrinsic enzymatic activity in its cytoplasmic domain. Hence, akin to other members of the TNFR family, it relies on the TNFR-Associated-Factor (TRAF) family of adaptor proteins to build the CD137 signalosome for transducing signals into the cell. Thus, upon CD137 activation by binding of CD137L trimers or by crosslinking with agonist monoclonal antibodies, TRAF1, TRAF2, and TRAF3 are readily recruited to the cytoplasmic domain of CD137, likely as homo- and/or heterotrimers with different configurations, initiating the construction of the CD137 signalosome. Read More

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November 2018
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The evolutionary history of Southern Africa.

Curr Opin Genet Dev 2018 Dec 3. Epub 2018 Dec 3.

Department of Zoology, University of Oxford, UK. Electronic address:

The genomic variability of Southern African groups is characterized by an exceptional degree of diversity, which is the result of long-term local evolutionary history, migrations and gene-flow. Over the last few years several investigations have identified and described signatures related to these processes, revealing how ancient and more recent events have shaped the structure and ancestry composition of local populations. Here we discuss recent insights into the genetic history of the Southernmost part of the African continent provided by the analysis of modern and ancient genomes. Read More

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December 2018

Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region.

BMC Res Notes 2018 Dec 6;11(1):869. Epub 2018 Dec 6.

Department of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.

Objective: Immune cell adaptor protein SKAP1 couples the antigen-receptor (TCR/CD3) with the activation of LFA-1 adhesion in T-cells. Previous work by ourselves and others have shown that SKAP1 can directly bind to other adaptors such as ADAP and RapL. However, it has been unclear whether SKAP1 can form homodimers with itself and the regions within SKAP1 that mediated homodimer formation. Read More

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December 2018

Genome-wide functional analyses of plant coiled-coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity.

PLoS Biol 2018 Dec 12;16(12):e2005821. Epub 2018 Dec 12.

Molecular Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.

The ability to induce a defense response after pathogen attack is a critical feature of the immune system of any organism. Nucleotide-binding leucine-rich repeat receptors (NLRs) are key players in this process and perceive the occurrence of nonself-activities or foreign molecules. In plants, coevolution with a variety of pests and pathogens has resulted in repertoires of several hundred diverse NLRs in single individuals and many more in populations as a whole. Read More

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December 2018
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Stability of doubly and triply H-bonded complexes governed by acidity-basicity relationships.

Chem Commun (Camb) 2018 Dec 12. Epub 2018 Dec 12.

Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Delegación Coyoacán, 04510 Ciudad de México, Mexico.

We used our recently proposed acidity-basicity interplay (ABI) model (Chem. Sci., 2018, 9, 4402) and the Jorgensen secondary interactions hypothesis (JSIH) to rationalise the experimentally observed trends in the formation constants of doubly and triply H-bonded systems with -NHO[double bond, length as m-dash]C- and -NHN- interactions. Read More

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December 2018

Cancer Immunotherapy: The Dawn of Antibody Cocktails.

Methods Mol Biol 2019 ;1904:11-51

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Since the approval of the first monoclonal antibody (mAb), rituximab, for hematological malignancies, almost 30 additional mAbs have been approved in oncology. Despite remarkable advances, relatively weak responses and resistance to antibody monotherapy remain major open issue. Overcoming resistance might require combinations of drugs blocking both the major target and the emerging secondary target. Read More

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January 2019

Preferential attentional engagement drives attentional bias to snakes in Japanese macaques (Macaca fuscata) and humans (Homo sapiens).

Sci Rep 2018 Dec 11;8(1):17773. Epub 2018 Dec 11.

School of Psychology, Curtin University, Perth, Western Australia, Australia.

In humans, attentional biases have been shown to negative (dangerous animals, physical threat) and positive (high caloric food, alcohol) stimuli. However, it is not clear whether these attentional biases reflect on stimulus driven, bottom up, or goal driven, top down, attentional processes. Here we show that, like humans, Japanese macaques show an attentional bias to snakes in a dot probe task (Experiment 1). Read More

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December 2018
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Safe Casting and Reliable Cusp Reconstruction Assisted by Micro-Computed Tomographic Scans of Fossil Teeth.

Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.

Department of Anthropology, The Ohio State University, 4034 Smith Laboratory, 174 West 18th Ave., Columbus, OH 43210, USA.

Dental replicas are frequently utilized in paleoanthropological studies of perikymata and enamel hypoplasia. However, fossil teeth are often fragile and worn, causing two problems: (1) the risk of damage by removing enamel fragments when impression-making material is separated from the fossil tooth surface, and (2) the need to reconstruct worn portions of the crown to assess perikymata number, distribution, and hypoplasia timing. This study presents the advantages of μCT data of canines and lateral incisors for (1) detecting cracks along the enamel-dentine junction (EDJ) which could cause damage when casting, and (2) reliably and non-destructively reconstructing worn or broken cusps. Read More

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December 2018

High expression of LASS2 is associated with unfavorable prognosis in patients with ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, China.

Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2), is a gene isolated from a human liver complementary DNA library. In this study, we found that LASS2 protein level was positively related to International Federation of Gynecology and Obstetrics (FIGO) stage and LASS2-negative tumors showed significant association with longer disease-free survival (DFS) and overall survival (OS) in ovarian cancer patients. The heterogeneous expression of LASS2 had been exhibited in diverse ovarian cancer cells. Read More

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December 2018

The long noncoding RNA NORAD enhances the TGF-β pathway to promote hepatocellular carcinoma progression by targeting miR-202-5p.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.

Hepatocellular carcinoma (HCC) is one of the most fatal cancers with common features of invasion and metastasis. Recent evidence indicate that the long noncoding RNA NORAD is a potential oncogene and is significantly upregulated in several cancers. However, the general biological role and clinical value of NORAD in HCC remains unknown. Read More

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December 2018

Board-like Fused-Thiophene Liquid Crystals and Their Benzene Analogues: Facile Synthesis, Self-assembly, p-Type Semiconductivity, and Photoluminescence.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

CNRS-University de Strasbourg, Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), Strasbourg, FRANCE.

Novel fused-thiophene discotic liquid crystals were designed and easily synthesized by Suzuki coupling and FeCl3 oxidized tandem cyclo-dehydrogenation reactions, including homo- and cross-coupling reactions. The resulting hexagonal and rectangular columnar mesomorphic supramolecular structures formed were characterized by polarizing optical microscopy, differential scanning calorimetry, and small-angle X-ray scattering. Charge carrier transport properties in the mesophases of two of the synthesized fused-thiophene discogens were measured by transient photocurrent time-of-flight (TOF) technique, revealing fast hole transport values in the range of 10-3 to 10-2 cm2 V-1s-1, thus demonstrating potential applications in electronic devices. Read More

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December 2018

Sialyl-LacNAc-PNA∙DNA concatamers by rolling circle amplification as multivalent inhibitors for Influenza A virus particles.

Chembiochem 2018 Dec 10. Epub 2018 Dec 10.

Humboldt Universität zu Berlin, Institut ür Chemie, Brook-Taylor-Str. 2, 12489, Berlin, GERMANY.

The surface of influenza A virus (IAV) particles is packed with hundreds of homo-trimeric hemagglutinins (HA). Monovalent sugars have low affinity but distance optimized bi- or trivalent sialyl-LacNAc (SLN) conjugates bind HA with 10³─10⁴-fold enhanced potency. Herein we describe the oligomerization of distance-optimized bivalent binders by branched and linear hybridization on long repetitive DNA templates. Read More

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December 2018
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Ladder-Type Nonacyclic Arene Bis(thieno[3,2-b]thieno)cyclopentafluorene as A Promising Building Block for Non-Fullerene Acceptor.

Chem Asian J 2018 Dec 10. Epub 2018 Dec 10.

CHINA.

A ladder-type nonacyclic arene (bis(thieno[3,2-b]thieno)cyclopentafluorene (BTTF)) has been designed and synthesized through fusing thienothiophenes with the fluorene core from the synthon of dimethyl 9,9-dioctyl-2,7-bis(thieno[3,2-b]thiophen-2-yl)fluorene-3,6-dicarboxylate. With BTTF as the central donor unit, a novel acceptor-donor-acceptor (A-D-A) type non-fullerene small molecule acceptor (BTTFIC) was prepared with 1,1-dicyanomethylene-3-indanones (IC) as the peripheral acceptor units. The energy level of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of BTTFIC locate at -5. Read More

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December 2018

Synthesis, Photophysical, Electrochemical and Thermal Study of Biphenyl Luminophors: Green Light Emitting Materials.

J Fluoresc 2018 Dec 10. Epub 2018 Dec 10.

D. B. F. Dayanand College of Arts and Science , Solapur, Solapur, India.

Novel luminophors of anthracene (AN) and tetracene (TN) doped biphenyl were prepared using Conventional Solid State reaction technique. Fluorescence spectroscopy, XRD, SEM, TGA-DSC and Cyclic Voltammetry techniques have been employed for photophysical, electrochemical and thermal study. The X-ray diffraction study revealed the formation of homogeneous biphenyl solid solutions with the added guests AN and TN. Read More

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December 2018
1 Read

Third Molar Extraction and Persistent Use of Opioids.

JAMA 2018 12;320(22):2377

School of Dentistry, University of Washington, Seattle.

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December 2018

Vitamin D Receptor Agonists for Patients Undergoing Hemodialysis.

JAMA 2018 12;320(22):2319-2321

Department of Medicine, Duke University School of Medicine, Durham, North Carolina.

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December 2018

Generating Homo- and Heterografts Between Watermelon and Bottle Gourd for the Study of Cold-responsive MicroRNAs.

J Vis Exp 2018 Nov 20(141). Epub 2018 Nov 20.

Institute of Vegetables, Zhejiang Academy of Agricultural Sciences; State Key Lab Breeding Base for Sustainable Control of Plant Pest and Disease, Zhejiang Academy of Agricultural Sciences;

MicroRNAs (miRNAs) are endogenous small non-coding RNAs of about 20 - 24 nt, known to play important roles in plant development and adaptation. There is an accumulating evidence showing that the expressions of certain miRNAs are altered when grafting, an agricultural practice commonly used by farmers to improve crop tolerance to biotic and abiotic stresses. Bottle gourd is an inherently climate-resilient crop compared to many other major cucurbits, including watermelon, rendering it one of the most widely used rootstocks for the latter. Read More

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November 2018

Dietary versatility of Early Pleistocene hominins.

Proc Natl Acad Sci U S A 2018 Dec 10. Epub 2018 Dec 10.

Senckenberg Biodiversity and Climate Research Centre, 60325 Frankfurt, Germany.

New geochemical data from the Malawi Rift (Chiwondo Beds, Karonga Basin) fill a major spatial gap in our knowledge of hominin adaptations on a continental scale. Oxygen (δO), carbon (δC), and clumped (Δ) isotope data on paleosols, hominins, and selected fauna elucidate an unexpected diversity in the Pleistocene hominin diet in the various habitats of the East African Rift System (EARS). Food sources of early and thriving in relatively cool and wet wooded savanna ecosystems along the western shore of paleolake Malawi contained a large fraction of C plant material. Read More

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December 2018

Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.

J Biol Chem 2018 Dec 10. Epub 2018 Dec 10.

Vanderbilt University, United States.

Lipid transport is an essential process with manifest importance to human health and disease. Phospholipid flippases (P4-ATPases) transport lipids across the membrane bilayer, and are involved in signal transduction, cell division, and vesicular transport. Mutations in flippase genes cause or contribute to a host of diseases such as cholestasis, neurological deficits, immunological dysfunction, and metabolic disorders. Read More

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December 2018
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Characteristics of seizure-induced signal changes on MRI in patients with first seizures: Comment on data sparsity.

Seizure 2018 12;63:113

Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran; Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

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December 2018

A peptide puzzle.

Elife 2018 12 7;7. Epub 2018 Dec 7.

Department of Pathology, Johns Hopkins School of Medicine, Baltimore, United States.

Why does cancer develop in situations where the immune system is perfectly capable of eliminating it? Read More

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December 2018

DFT-Based QSAR Modelling of Inhibitory Activity of Coumarins and Sulfocoumarins on Carbonic Anhydrase (CA) Isoforms (CA I and CA II).

Authors:
Erol Eroğlua

Curr Comput Aided Drug Des 2018 Dec 10. Epub 2018 Dec 10.

Department of Mathematics and Sciences Education, Faculty of Education, Akdeniz University, Dumlupınar Bulvarı, Kampüs, 07058, Antalya. Turkey.

Objective: We present three robust, validated and statistically significant quantitative structure-activity relationship (QSAR) models, which deal with the calculated molecular descriptors and experimental inhibition constant (Ki) of 42 coumarin and sulfocoumarin derivatives measured against CA I and II isoforms.

Method: The compounds were subjected to DFT calculations in order to obtain quantum chemical molecular descriptors. Multiple linear regression algorithm was applied to construct QSAR models. Read More

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December 2018

Enhancement of Antiaromatic Character via Additional Benzoannulation into Dibenzo[a,f]pentalene: Syntheses and Properties of Benzo[a]naphtho[2,1-f]pentalene and Dinaphtho[2,1-a,f]pentalene.

J Am Chem Soc 2018 Dec 11. Epub 2018 Dec 11.

Understanding the structure-property relationships in antiaromatic molecules is crucial to controlling their electronic properties and designing new organic optoelectronic materials. Dibenzo[a,f]pentalene, a structural isomer of dibenzopentalene, displays open-shell and antiaromatic character harmonization, which is not shared by the well-known isomer, dibenzo[a,e]pentalene. The next ques-tions of interest concern the topological effects of the π-extension on the harmonization of the open-shell and antiaromatic charac-ter in the dibenzo[a,f]pentalene π-system. Read More

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December 2018

One-pot carbonization of chitosan/P123/PdCl blend hydrogel membranes to N-doped carbon supported Pd catalytic composites for Ullmann reactions.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing 312000, China. Electronic address:

Novel porous nitrogen-doped carbon supported Pd (Pd@N-C) catalytic composites were prepared by one-pot thermal carbonization of chitosan/poly(ethylene glycol)‑block‑poly(propylene glycol)‑block‑poly(ethylene glycol)/PdCl (CS/P123/PdCl) blend hydrogel membranes at different temperature in N atmosphere. The porous structure of the Pd@N-C catalytic composite was governed by both the addition of P123 and the carbonization temperature. At highest carbonization temperature of 900 °C, the prepared Pd@N-C catalytic composite from CS/P123/PdCl blend membrane showed the highest specific area (S) of 293. Read More

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December 2018
5 Reads

Letter to the Editor: The Opioid Prescribing Scenario in Portugal from a Primary Care Perspective.

Acta Med Port 2018 Nov 30;31(11):698-699. Epub 2018 Nov 30.

Unidade de Saúde Familiar Dafundo. Agrupamento de Centros de Saúde de Lisboa Ocidental e Oeiras. Oeiras. Portugal.

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November 2018
3 Reads

Letter to The Editor: Access to Opioids, A Global Challenge - Impressions of The Brazilian Scenario.

Authors:
Carolina Neiva

Acta Med Port 2018 Nov 30;31(11):698. Epub 2018 Nov 30.

Serviço de Cuidados Paliativos. Instituto de Assistência ao Servidor Público Estadual. São Paulo. Brazil.

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November 2018
3 Reads

Oligomerization of equilibrative nucleoside transporters: a novel regulatory and functional mechanism involving PKC and PP1.

FASEB J 2018 Dec 6:fj201800440RR. Epub 2018 Dec 6.

Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.

Equilibrative nucleoside transporters (ENTs) translocate nucleosides and nucleobases across plasma membranes, as well as a variety of anti-cancer, -viral, and -parasite nucleoside analogs. They are also key members of the purinome complex and regulate the protective and anti-inflammatory effects of adenosine. Despite their important role, little is known about the mechanisms involved in their regulation. Read More

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December 2018
3 Reads

Functionalized Silver Ion Mediated α-dC-β-dC Hybrid Base Pairs with Exceptional Stability: α-d 5-Iodo-2'-Deoxycytidine and Its Octadiynyl Derivative in Metal DNA.

Chemistry 2018 Dec 6. Epub 2018 Dec 6.

Universität Osnabrück, Institut für Chemie neuer Materialien, Barbarastraße 7, 49076, Osnabrück, GERMANY.

Silver-mediated α-dC-Ag+-β-dC hybrid base pairs decorated with 5-iodo- or 5-octadiynyl residues are well accommodated in duplex DNA. A strong Tm increase and favorable thermodynamic data for duplex DNA were observed after addition of silver ions. The phenomenon is particularly obvious when both nucleobases of the base pairs are functionalized. Read More

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December 2018
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Visualization of Exo- and Endocytosis of AMPA Receptors During Hippocampal Synaptic Plasticity Around Postsynaptic-Like Membrane Formed on Glass Surface.

Authors:
Tomoo Hirano

Front Cell Neurosci 2018 21;12:442. Epub 2018 Nov 21.

Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto, Japan.

Regulation of exo- and endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor (AMPAR) plays a critical role in the expression of synaptic plasticity such as long-term potentiation (LTP) and long-term depression (LTD) at excitatory central synapses. Enhanced AMPAR exocytosis or endocytosis has been suggested to contribute to LTP or LTD, respectively. However, several unsettled fundamental questions have remained about AMPAR exo- and endocytosis in the basal condition and during synaptic plasticity: (1) Does the size of each exo- or endocytosis event, and/or do the frequencies of these events change during LTP or LTD? If they change, what are the time courses of the respective changes? (2) Where does the exo- or endocytosis preferentially occur in each condition: inside or in the vicinity of postsynaptic membrane, or in the extrasynaptic membrane? (3) Do different types of AMPAR, such as GluA1 homo-tetramer, GluA1/2 hetero-tetramer and GluA2/3 hetero-tetramer, show distinct exo- and endocytosis changes? To address these questions, we developed new methods to observe individual events of AMPAR exo- or endocytosis with a high signal to noise (SN) ratio in a culture preparation using total internal reflection fluorescence microscopy (TIRFM). Read More

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November 2018
3 Reads

Background-free fluorescence decay time sensing and imaging of pH with highly photostable diazaoxotriangulenium dyes.

Anal Chem 2018 Dec 6. Epub 2018 Dec 6.

Novel fluorescent diazaoxatriangulenium (DAOTA) pH indicators for lifetime-based self-referenced pH sensing are reported. The DAOTA dyes were decorated with phenolic receptor groups inducing fluorescence quenching via photoinduced electron transfer mechanism. Electron-withdrawing chlorine substituents ensure response in the most relevant pH range (apparent pK'a values ~5 and 7. Read More

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December 2018

Photoelectron Spectroscopy and Theoretical Study of CrnSi15-n- (n = 1-3): Effects of Doping Cr Atoms on the Structural and Magnetic Properties.

J Phys Chem A 2018 Dec 3. Epub 2018 Dec 3.

CrnSi15-n- (n = 1-3) clusters were investigated by using size-selected anion photoelectron spectroscopy combined with density functional theory calculations. The results show that the most stable structure of CrSi14- is of C2v symmetry with the Cr atom encapsulated in a Si14 cage which can be viewed as a boat-shaped Si10 unit capping by four additional silicon atoms. A large HOMO-LUMO gap of neutral CrSi14 is confirmed based on the photoelectron spectrum of CrSi14- anion. Read More

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December 2018

Stable Thiele's Hydrocarbon Derivatives Exhibiting Near-Infrared Absorption/Emission and Two-Step Electrochromism.

J Am Chem Soc 2018 Dec 3. Epub 2018 Dec 3.

We report synthesis and characterization of near-infrared (NIR)-absorbing/emitting Thiele's hydrocarbon derivatives, in which four aryl groups are bridged to a quinodimethane skeleton. The quinoid structure of the bridged-tetra-aryl-p-quinodimethanes (BTAQs) was confirmed by spectroscopic, X-ray crystallographic, and computational methods. Although quinodimethane derivatives with a small HOMO-LUMO energy gap often exhibit biradical character, BTAQs showed no biradical character. Read More

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December 2018

Scapular anatomy of Paranthropus boisei from Ileret, Kenya.

J Hum Evol 2018 Dec;125:181-192

Division of Anthropology, American Museum of Natural History, NY, USA; Humboldt Foundation Fellow at Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Germany.

KNM-ER 47000A is a new 1.52 Ma hominin scapular fossil belonging to an associated partial skeleton from the Koobi Fora Formation, Kenya (FwJj14E, Area 1A). This fossil effectively doubles the record of Early Pleistocene scapulae from East Africa, with KNM-WT 15000 (early African Homo erectus) preserving the only other known scapula to date. Read More

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December 2018
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The impact of hand proportions on tool grip abilities in humans, great apes and fossil hominins: A biomechanical analysis using musculoskeletal simulation.

J Hum Evol 2018 Dec 14;125:106-121. Epub 2018 Nov 14.

Department of Adaptations du Vivant, UMR 7179-CNRS/MNHN, MECADEV, Paris, 75321, France.

Differences in grip techniques used across primates are usually attributed to variation in thumb-finger proportions and muscular anatomy of the hand. However, this cause-effect relationship is not fully understood because little is known about the biomechanical functioning and mechanical loads (e.g. Read More

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December 2018

A palaeopathological analysis of skeletal remains from Bronze Age Mongolia.

Homo 2018 Nov 23;69(6):324-334. Epub 2018 Nov 23.

Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, USA.

Little is known about the lifeways of the people who inhabited the Mongolian steppe during the Bronze Age (c. 4450-2650 BP). Palaeopathological analysis allows us to draw inferences about the lifeways of past people from the indicators of health and lifestyle recorded in human remains. Read More

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November 2018
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The mental foramen: A cone beam CT study of the horizontal location, size and sexual dimorphism amongst living Jordanians.

Homo 2018 Nov 24;69(6):335-339. Epub 2018 Nov 24.

Department of Conservative Dentistry, School of Dentistry, The University of Jordan, Amman 11942, Jordan.

Accurate information regarding the horizontal location and size of mental foramen (MF) has a well-known clinical importance. In addition, these variables have been reported to exhibit inter-population variation. The aims of the present study were to study the horizontal position and size of MF, as seen on cone beam CT (CBCT) images, and to assess sexual dimorphism in these variables. Read More

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November 2018

Recent Progress in Polynuclear Ruthenium Complex-Based DNA Binders/Structural Probes and Anticancer Agents.

Curr Med Chem 2018 Dec 3. Epub 2018 Dec 3.

Beijing Key Laboratory of Energy Conversion and Storage Materials, College of Chemistry, Beijing Normal University, Beijing 100875. China.

Ruthenium complexes have stood out by several mononuclear complexes which have entered into clinical trials, such as imidazolium [trans-RuCl4(1H-imidazole)(DMSO-S)] (NAMI-A) and ([Ru(II)(4,4'-dimethyl-2, '-bipyridine)2-(2(2 '-,2 ' ':5 ' ',2 ' ' ' - terthiophene)-imidazo[4,5-f][1,10]phenanthroline)]2+) (TLD-1433), opening a new avenue for developing promising ruthenium-based anticancer drugs alternative to Cisplatin. Polynuclear ruthenium complexes were reported to exhibit synergistic and/or complementary effects: the enhanced DNA structural recognition and DNA binding as well as in vitro anticancer activities. This review overviews some representative polynuclear ruthenium complexes acting as DNA structural probes, DNA binders and in vitro anticancer agents, which were developed during last decades. Read More

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December 2018
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Homologous pairing activities of Arabidopsis thaliana RAD51 and DMC1.

J Biochem 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.

In eukaryotes, homologous recombination plays a pivotal role in both genome maintenance and generation of genetic diversity. Eukaryotic RecA homologues, RAD51 and DMC1, are key proteins in homologous recombination that promote pairing between homologous DNA sequences. Arabidopsis thaliana is a prominent model plant for studying eukaryotic homologous recombination. Read More

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December 2018
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