26,655 results match your criteria Holistic Nursing Practice [Journal]


Biology of preeclampsia: Combined actions of angiogenic factors, their receptors and placental proteins.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 12. Epub 2018 Dec 12.

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria. Electronic address:

Although massive efforts have been undertaken to elucidate the etiology of the pregnancy syndrome preeclampsia, its developmental origin remains a mystery. Most efforts of the last decade have focused on biomarkers to predict and/or diagnose preeclampsia, including the anti-angiogenic factor sFlt-1 (soluble fms-like tyrosin kinase-1), the angiogenic factor PGF (placental growth factor) and PP13 (placental protein 13). The origins of these marker proteins are still under debate, and so far their actions have only been describe separate from each other. Read More

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December 2018

Lessons from PrEP: A Qualitative Study Investigating How Clinical and Policy Experts Weigh Ethics and Evidence When Evaluating Preventive Medications for Use in Pregnant and Breastfeeding Women.

AIDS Behav 2018 Dec 14. Epub 2018 Dec 14.

The Ethox Centre and Wellcome Centre for Ethics & Humanities, Nuffield Department of Population Health, University of Oxford, Oxford, England, UK.

This study explored how multinational HIV experts weigh clinical, evidential, and ethical considerations regarding pre-exposure prophylaxis in pregnant/breastfeeding women. Semi-structured interviews were conducted with experts in HIV policy, research, treatment, and implementation from three global regions. A constant comparative approach identified major themes. Read More

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December 2018
1 Read

Definition of whole person care in general practice in the English language literature: a systematic review.

BMJ Open 2018 Dec 14;8(12):e023758. Epub 2018 Dec 14.

Psycho-Oncology Co-operative Research Group, Sydney Health Ethics, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia.

Objectives: The importance of 'whole person' or 'holistic' care is widely recognised, particularly with an increasing prevalence of chronic multimorbidity internationally. This approach to care is a defining feature of general practice. However, its precise meaning remains ambiguous. Read More

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December 2018

Integrated Care Management of Patients With Atrial Fibrillation and Risk of Cardiovascular Events: The ABC (Atrial fibrillation Better Care) Pathway in the ATHERO-AF Study Cohort.

Mayo Clin Proc 2018 Dec 11. Epub 2018 Dec 11.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark. Electronic address:

Objective: To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathway.

Patients And Methods: This prospective single-center cohort study included 907 consecutive patients with nonvalvular AF on vitamin K antagonists from February 2008 to December 2016. The A, B, and C groups were defined as follows: "A" by a Time in Therapeutic Range ≥65%; "B" by a European Heart Rhythm Association (EHRA) symptom scale I-II, and "C" as optimized cardiovascular comorbidity management. Read More

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December 2018

Current and ceased users of sit stand workstations: a qualitative evaluation of ergonomics, safety and health factors within a workplace setting.

BMC Public Health 2018 Dec 14;18(1):1374. Epub 2018 Dec 14.

Centre for Ergonomics and Human Factors, School of Psychology and Public Health, College of Science, Health and Engineering, Latrobe University, Melbourne, Australia.

Background: Many workplaces have implemented sit-stand workstations (SSW), which enable a worker to transition between sitting and standing as they perform their work activities. The factors which determine the initial adoption, sustainability or cessation of use for a SSW, remain largely unexamined. This study investigates the experiences of workers who had previously used or were currently using a SSW. Read More

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December 2018

Academic monitoring and support of undergraduate nursing education programme: A middle-range theory.

Curationis 2018 Dec 3;41(1):e1-e11. Epub 2018 Dec 3.

School of Nursing and Public Health, University of KwaZulu-Natal.

Background:  Globally, there is consensus on the need for student support to address high student attrition and low throughputs, especially in nursing and midwifery programmes.

Objectives:  This study analysed the implementation of academic monitoring and support (AMS) in an undergraduate nursing programme to generate a context-informed academic monitoring and support middle-range theory.

Method:  An ethnographic design and grounded theory approach were adopted in this study. Read More

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December 2018
1 Read

A Mini Review on Antidiabetic Properties of Fermented Foods.

Nutrients 2018 Dec 13;10(12). Epub 2018 Dec 13.

Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.

In general, fermented foods (FFs) are considered as functional foods. Since the awareness about the health benefits of FFs has increased, the consumption of FF also improved significantly in recent decades. Diabetes is one of the leading threats of the health span of an individual. Read More

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December 2018

A survey of US early childhood caries programs: findings and recommendations.

J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.

Section of Population Oral Health, Columbia University College of Dental Medicine, New York, NY, USA.

Objectives: To identify and characterize US early childhood caries (ECC) programs.

Methods: A 39 question online survey was fielded to 245 ECC programs identified from the literature and peer programs. The 101 respondents (41 percent response rate) reported their program's geographic reach, type, areas of focus, target populations, approaches, affiliations, providers, goals, costs, and funding. Read More

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December 2018
3 Reads

The human visual system estimates angle features in an internal reference frame: A computational and psychophysical study.

J Vis 2018 Dec;18(13):10

Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics, Ministry of Education, School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.

Angle perception is an important middle-level visual process, combining line features to generate an integrated shape percept. Previous studies have proposed two theories of angle perception-a combination of lines and a holistic feature following Weber's law. However, both theories failed to explain the dual-peak fluctuations of the just-noticeable difference (JND) across angle sizes. Read More

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December 2018

Transgender inmates: A systems-based model for assessment and treatment planning.

Psychol Serv 2018 Dec 13. Epub 2018 Dec 13.

Correct Care Solutions.

Concepts of gender, gender roles, and gender norms have continuously adapted with the increased acceptance of diversity throughout the United States in recent decades. Although guidelines exist regarding competent assessment and treatment of transgender individuals, correctional environments place substantial restrictions and complications on this process. Recent legal cases have increased public awareness of such cases, including challenges to the status quo of which responsibilities fall under the purview of correctional systems. Read More

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December 2018
1 Read

[Holistic concept of rhinoplasty].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1444-1446

In the past 20 years, nasal cavity plasty was operated by the otolaryngologists, while external rhinoplasty was usually implemented by the plastic surgeon respectively. The holistic concept is about the integrity, unity and connection of things and phenomena.Considering the structure and function of the external nose and the nasal cavity as a whole,we review the holistic concept in rhinoplasty and put forward the operation of holistic rhinoplasty, including the nasal cavity plasty and external rhinoplasty, correcting the structure problems of nasal cavity and the external nose deformity, and restoring its physiological and cosmetic functions at the same time. Read More

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September 2018

Lymphatic Vessel Network Structure and Physiology.

Compr Physiol 2018 Dec 13;9(1):207-299. Epub 2018 Dec 13.

Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease. Read More

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December 2018
2 Reads

Revisiting the difference between instrumental and terminal values to predict (stimulating) prosocial behaviours: The transcendental-change profile.

Br J Soc Psychol 2018 Dec 12. Epub 2018 Dec 12.

Universidad de Buenos Aires, Argentina.

Past research suggests that the connection between values and people's behaviour may not be as straightforward and robust as has been claimed. We propose that a more holistic and discriminative view that acknowledges the influence of a specific combination of values on specific kinds of behaviour is needed. In the current project, we test two hypotheses regarding the transcendental-change profile (TCP). Read More

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December 2018

[Introduction: Reduction of social inequalities in health has been one of the main political pillars of Regional Health Agencies in France since their creation in 2009. This paper presents a contextual analysis of the effects on social inequalities in health of a hospital-based health promotion and disease prevention programme in terms of overall health policy and scope.Methods: Qualitative analysis was used to describe the impact on social inequalities in health according to the classification proposed by Diderichsen et al. Carey’s framework was used to apply proportionate universalism in order to analyse its action on these inequalities, adopting a contextualised and holistic approach with regard to regional and national public policy. The results showed that the intervention focused on targeted actions, but may have broader applications. The intervention strategy shifts between closing the inequality gap and levelling up the social gradient. However, analysis of this type of intervention using the proportionate universalism framework may lead to a revised view of the effects of the intervention on social inequalities in health.Results: Implementing health-equity focused interventions remains a challenge for each institution, including Regional Health Agencies. However, research on hospital-based preventive interventions highlights contrasting results in terms of social gradient, depending on whether the intervention is considered in isolation or in its broader context.Discussion].

Sante Publique 2018 Sep;S2(HS2):25-32

Introduction: Reduction of social inequalities in health has been one of the main political pillars of Regional Health Agencies in France since their creation in 2009. This paper presents a contextual analysis of the effects on social inequalities in health of a hospital-based health promotion and disease prevention programme in terms of overall health policy and scope.

Methods: Qualitative analysis was used to describe the impact on social inequalities in health according to the classification proposed by Diderichsen et al. Read More

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September 2018

Development of Fangjiomics for Systems Elucidation of Synergistic Mechanism Underlying Combination Therapy.

Comput Struct Biotechnol J 2018 20;16:565-572. Epub 2018 Nov 20.

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.

The rapid development of omics technology provides an opportunity for fulfilling the understanding of the synergistic mechanism of combination therapy. However, a systems theory to analyze synergy remains an ongoing challenge. Fangjiomics is a novel systems science based on a holistic theory integrated with reductionism which has been utilized to systematically elucidate the synergistic mechanisms underlying combination therapy using multi-target-, pathway- or network-based quantitative methods. Read More

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November 2018

The importance of patient perspectives in pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Pulmonary Hypertension Association, Silver Spring, MD, USA.

The assessment of objective measurement of cardiopulmonary status has helped us achieve better clinical outcomes for patients and develop new therapies through to the point of market access; however, patient surveys indicate that more can be done to improve holistic care and patient engagement. In this multidisciplinary review, we examine how clinical teams can acknowledge and embrace the individual patient's perspective, and thus improve the care for individual patients suffering from pulmonary hypertension by cultivating the importance and relevance of health-related quality of life in direct clinical care. At the individual level, patients should be provided with access to accredited specialist centres which provide a multidisciplinary approach where there is a culture focused on narrative medicine, quality of life, shared decision making and timely access to palliative care, and where there is participation in education. Read More

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December 2018
7.636 Impact Factor

Need for comprehensive standardization strategies for marketed Ayurveda formulations.

J Ayurveda Integr Med 2018 Dec 11. Epub 2018 Dec 11.

Centre for Ayurveda Biology and Holistic Nutrition, The University of Trans-Disciplinary Health Sciences and Technology (TDU), Bengaluru, Karnataka, India. Electronic address:

Ayurveda is known for the use of poly-herbal formulations and multi-component therapeutics for the management of health and diseases. Several pharmaceutical companies are manufacturing and marketing different Ayurvedic formulations, prepared as per the classical texts and the regulatory standards. However, on a cursory glance, marked variations are observed amongst the same formulations manufactured by different companies. Read More

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December 2018

Ventilation/Perfusion SPECT Imaging-Diagnosing Other Cardiopulmonary Diseases Beyond Pulmonary Embolism.

Semin Nucl Med 2019 Jan 20;49(1):4-10. Epub 2018 Nov 20.

Department of Pulmonary Medicine, Heart and Lung Center, Helsinki University Hospital and Helsinki University, Helsinki, Finland. Electronic address:

Ventilation/perfusion single-photon emission computed tomography (V/P SPECT) is the scintigraphic technique recommended primarily for the diagnosis of acute pulmonary embolism (PE) and is golden standard for the diagnosis of chronic PE. Furthermore, interpreting ventilation and corresponding perfusion images enables pattern recognition of many other cardiopulmonary disorders that affect lung function and also allows quantification of their extent. Using Technegas for the ventilation imaging, grading of small airway disease in COPD is possible and the method is recommended for PE diagnosis in patients with severe COPD that is not possible with radiolabelled liquid aerosols. Read More

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January 2019

Age-Tastic! An Evaluation of an Evidence-Based Intervention for Older Adults.

Healthcare (Basel) 2018 Dec 8;6(4). Epub 2018 Dec 8.

New York City Department for the Aging, New York, NY 10007, USA.

: Raising awareness of holistic health and safety among older adults is critical to enhancing their wellbeing in many cases, improving health outcomes and motivating positive behavioral changes. Age-Tastic! is a comprehensive health and safety promotion intervention that uses the concept of a competitive board game to entice older adults to participate and stay engaged. : The purpose of this study was to evaluate the impact of Age-Tastic! on the level of awareness, health literacy, self-efficacy and positive behavioral change among the participants. Read More

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December 2018

Einschränkungen in der Gehfähigkeit und der Sprunggelenksdorsalflexion bei Kindern nach intensiver Krebsbehandlung.

Klin Padiatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.

Background: With improved survival rates in pediatric oncology, the detection of adverse side- and late-effects is gaining increased interest. This cross-sectional study investigated walking abilities and ankle dorsiflexion function in children with cancer.

Patients: Study participants included 16 children with various cancers (4-20 years, patient group) after completion of the intense treatment and 16 age- and gender-matched healthy peers (comparison group). Read More

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December 2018

Using a holistic health approach to achieve weight-loss maintenance: results from the Spirited Life intervention.

Transl Behav Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Biostatistics and Bioinformatics, Duke Global Health Institute, Duke University, Durham, NC, USA.

Weight-loss maintenance is essential to sustain the health benefits of weight loss. Studies with lower intensity intervention supports under real-world conditions are lacking. This study examined changes in weight and cardiometabolic biomarkers among Spirited Life participants following initial 12-month weight loss at 12-24 months and 24-42 months. Read More

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December 2018

A holistic view on implementing hospital autonomy reforms in developing countries: a systematic review.

Health Policy Plan 2018 Dec 13. Epub 2018 Dec 13.

World Health Organization, Regional Office for the Eastern Mediterranean, Monazamet El Seha El Alamia Street, Extension of Abdel Razak El Sanhouri Street, P.O. Box 7608, Nasr City 11371, Cairo, Egypt.

The excessive use of resources, inefficiency and poor service quality in public hospitals has led developing countries to create reforms in public hospital governance, including autonomization. Hospital autonomy refers to the delegation of administrative rights to the hospital management team. The purpose of the present research is to review different aspects of hospital autonomy reforms in developing countries, such as incentives, preparations, obstacles and facilitators to change prior to implementation, impacts on achieving Universal Health Coverage (UHC) goals, challenges, outcomes and implications for implementation. Read More

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December 2018

Determining landscape-level drivers of variability for over fifty soil chemical elements.

Sci Total Environ 2018 Dec 4;657:279-286. Epub 2018 Dec 4.

College of Agro-grassland Science, Nanjing Agricultural University, Nanjing 210095, China; Department of Grassland Science, China Agricultural University, Beijing 100193, China.

Syntheses of large datasets have allowed increased clarity of distribution patterns and variation in soil major and trace elements. However, the drivers of variation in topsoil elements across biogeographical scales are not well understood. Our aim was to (1) identify how landscape-scale climate, geographical features, and edaphic factors influence soil elements, and (2) determine key environmental thresholds for shifts in soil element concentration. Read More

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December 2018
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Healthcare Providers' Perceived Communication Barriers to Offering Palliative Care to Patients With Heart Failure: An Integrative Review.

J Cardiovasc Nurs 2018 Dec 11. Epub 2018 Dec 11.

Marianne K. Schallmo, DNP, ANP-BC Clinical Assistant Professor of Nursing, School of Nursing, Purdue University Northwest, Hammond, Indiana. Sharon Dudley-Brown, PhD, FNP-BC, FAAN Associate Professor of Nursing, School of Nursing, University of Delaware, Newark. Patricia M. Davidson, PhD, MEd, BA, FAAN Dean of Nursing, School of Nursing, Johns Hopkins University, Baltimore, Maryland.

Context: Heart failure is a chronic complex syndrome that is common and burdensome. International clinical practice guidelines recommend that healthcare providers communicate palliative care options with patients with heart failure.

Objectives: The aim of this study was to conduct an integrative review to evaluate how healthcare providers perceived communication barriers to offering information to individuals in the palliative phase of heart failure. Read More

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December 2018

Transboundary nomadic population movement: a potential for import-export of poliovirus.

BMC Public Health 2018 Dec 13;18(Suppl 4):1316. Epub 2018 Dec 13.

National Primary Health Care Development Agency, Abuja, Nigeria.

Background: Nomadic populations have a considerably higher risk of contracting a number of diseases but, despite the magnitude of the public health risks involved, they are mostly underserved with few health policies or plans to target them. Nomadic population movements are shown to be a niche for the transmission of diseases, including poliomyelitis. The nomadic routes traverse the northern states of Nigeria to other countries in the Lake Chad subregion. Read More

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December 2018

Review of the Spatial Distribution, Source and Extent of Heavy Metal Pollution of Soil in China: Impacts and Mitigation Approaches.

J Health Pollut 2018 Mar 12;8(17):53-70. Epub 2018 Mar 12.

Fujian Normal University, College of Geographical Sciences, State Key Laboratory of Mountain Ecology, Department of GIS and Cartography, Fuzhou, China.

Background: China has undergone a rapid industrial revolution and urbanization during the past three decades. This expansion is largely responsible for the release of a large amount of heavy metals into soils and is increasingly raising concerns over the potential effects on human health and the environment. The problem is drawing increasing attention, especially after an extensive nationwide soil survey report in 2014. Read More

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Application of metabolomics in toxicity evaluation of traditional Chinese medicines.

Chin Med 2018 4;13:60. Epub 2018 Dec 4.

3State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009 China.

Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable attention in the past two decades. Metabolomics is an "omics" approach that aims to comprehensively analyze all metabolites in biological samples. Read More

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December 2018

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer.

Front Pharmacol 2018 22;9:1371. Epub 2018 Nov 22.

Department of Medical Oncology, Holistic Integrative Oncology Institutes and Holistic Integrative Cancer Center of Traditional Chinese and Western Medicine, The Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou, China.

Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis, as a non-apoptotic form of cell death, is emerging in specific cancer types; however, its relevance in colorectal cancer (CRC) is unexplored and remains unclear. Read More

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November 2018

Environmental considerations in the Swedish building and construction industry: the role of costs, institutional setting, and information.

J Hous Built Environ 2018 23;33(4):615-632. Epub 2018 Jan 23.

2School of Engineering, Jönköping University, Jönköping, Sweden.

Despite increasing evidence that being an environment-friendly company not only benefits the environment but also makes long-term economic sense, the transition to a more sustainable society is extremely slow. This is true of the building and construction industry as well. At a strategic level, environmental issues have received more attention with the establishment of roles such as environmental managers and implementation of advanced environmental management systems. Read More

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January 2018

A fish out of water: experience of working with the Māori people in New Zealand.

Authors:
Rebecca Chubb

BJPsych Int 2018 Nov;15(4):91-92

Specialty Doctor in Old Age Psychiatry, North Staffordshire Combined Healthcare Trust; email

Experiencing life and work in an alien culture initially just felt unsettling, but it also really challenged how I perceived myself and my abilities as a doctor. Being the outsider in a group has the ability to hold an uncomfortable and scrutinising mirror up to yourself. It also offers a unique opportunity to reconsider the skills, attributes and knowledge needed to be a psychiatrist. Read More

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November 2018

The impact of external facial features on the construction of facial composites.

Ergonomics 2018 Dec 7:1-54. Epub 2018 Dec 7.

d School of Psychology , University of Central Lancashire , Preston PR1 2HE.

Witnesses may construct a composite face of a perpetrator using a computerised interface. Police practitioners guide witnesses through this unusual process, the goal being to produce an identifiable image. However, any changes a perpetrator makes to their external facial-features may interfere with this process. Read More

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December 2018

Medical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome: JACC State-of-the-Art Review.

J Am Coll Cardiol 2018 Dec;72(23 Pt A):2886-2903

Interventional Cardiology Unit, GVM Care & Research Maria Cecilia Hospital, Cotignola, Italy.

Following an acute coronary syndrome (ACS), heightened predisposition to atherothrombotic events may persist for years. Advances in understanding the pathobiology that underlies this elevated risk furnish a mechanistic basis for devising long-term secondary prevention strategies. Recent progress in ACS pathophysiology has challenged the focus on single "vulnerable plaques" and shifted toward a more holistic consideration of the "vulnerable patient," thus highlighting the primacy of medical therapy in secondary prevention. Read More

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December 2018

Turning Pain into Gain: Evaluation of a Multidisciplinary Chronic Pain Management Program in Primary Care.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Queensland 4222, Australia and Menzies Health Institute Queensland, Gold Coast Campus, Griffith University, Queensland 4222, Australia.

Objective: To measure the impact of the multidisciplinary Turning Pain Into Gain program in people experiencing chronic pain of any etiology.

Methods: A mixed-methods observational study of 252 participants was used to explore the impact of Turning Pain Into Gain on medication use; quality of life and functioning, as measured by the Pain Self-Efficacy Questionnaire; and self-reported hospitalizations between 2015 and 2016.

Results: Responses from 178 participants showed an increased alignment with Australian pain medication guidelines (e. Read More

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December 2018

Perceptions of a Good Death in Children with Life-Shortening Conditions: An Integrative Review.

J Palliat Med 2018 Dec 11. Epub 2018 Dec 11.

2 International Observatory on End of Life Care, Lancaster University , Lancaster, United Kingdom .

Background: For children with life-shortening illness, achieving a "good death" can be a tacit goal. There is little understanding of how different stakeholders perceive what a "good death" might be.

Objective: To review empirical literature to construct an understanding of a "good death" for children with life-shortening conditions. Read More

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December 2018
2 Reads

River water analysis using a multiparametric approach: Portuguese river as a case study.

J Water Health 2018 Dec;16(6):991-1006

Department of Aquatic Production, Abel Salazar Institute for the Biomedical Sciences (ICBAS), University of Porto, 4050-313 Porto, Portugal E-mail: LAQV, Requimte, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.

The Ave River in northern Portugal has a history of riverbanks and water quality degradation. The river water quality was assessed by physicochemical, biological (macroinvertebrates) and microbiological (Enterococcus spp. and Escherichia coli) parameters in six locations (A-F, point A being the nearest to the source) throughout its course during a year. Read More

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December 2018

The comparison of violence, and the relationship with childhood trauma in Turkish men with alcohol, opiate, and synthetic cannabinoid use disorder.

Neuropsychiatr Dis Treat 2018 23;14:3169-3178. Epub 2018 Nov 23.

Practise and Research Center for Fight Againist Addiction, University of Health Sciences,

Objective: The objectives of this study are, first, to explore the prevalence of lifetime violent and criminal behaviors among alcohol, opioid, and synthetic cannabinoid (SC) users in the treatment program; second, to examine and compare sociodemographic characteristics, childhood traumatic experiences, and impulsivity of these groups.

Patients And Method: This cross-sectional cohort study includes 110 male patients who received inpatient treatment in AMATEM (Alcohol and Substance Addiction Treatment Center) Clinic of Erenköy Training and Research Hospital for Psychiatry and Neurology between October 2014 and May 2015, diagnosed with alcohol, opioid, SC use disorder. The patients who were included in the study were given Data Collection Form, APIsoft (Addiction Profile Index), Childhood Trauma Questionnaire (CTQ-28), and Barratt Impulsiveness Scale (BIS-11). Read More

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November 2018

Bretschneider solution-induced alterations in the urine metabolome in cardiac surgery patients.

Sci Rep 2018 Dec 11;8(1):17774. Epub 2018 Dec 11.

Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou branch, College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan.

The development of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) cardioplegia solution represented a major advancement in cardiac surgery, offering significant myocardial protection. However, metabolic changes induced by this additive in the whole body have not been systematically investigated. Using an untargeted mass spectrometry-based method to deeply explore the urine metabolome, we sought to provide a holistic and systematic view of metabolic perturbations occurred in patients receiving HTK. Read More

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December 2018

Plasmonic-Assisted Graphene Oxide Artificial Muscles.

Adv Mater 2018 Dec 9:e1806386. Epub 2018 Dec 9.

State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Haidian district, Beijing, 100084, China.

Muscles and joints make highly coordinated motion, which can be partly mimicked to drive robots or facilitate activities. However, most cases primarily employ actuators enabling simple deformations. Therefore, a mature artificial motor system requires many actuators assembled with jointed structures to accomplish complex motions, posing limitations and challenges to the fabrication, integration, and applicability of the system. Read More

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December 2018
2 Reads

Metabolic and physiological responses of Mediterranean high-mountain and Alpine plants to combined abiotic stresses.

Physiol Plant 2018 Dec 10. Epub 2018 Dec 10.

Departamento de Farmacología, Farmacognosia y Botánica, Unidad de Fisiología Vegetal. Facultad de Farmacia. Universidad Complutense de Madrid, Spain.

High-mountain areas provide excellent opportunities to study the effects of combined abiotic stresses on plant physiology given their variety of steep ecological gradients, low anthropogenic disturbance, and remarkable levels of taxonomic diversity. Efficient photoprotective and antioxidant scavenging mechanisms are vital for survival in high-mountain plants, having its altitudinal and seasonal variations determined by environmental or ontogenetic factors such as the decrease in mean temperatures and water availability. A number of stress indicators have been described in order to rapidly assess plant fitness in high-mountain environments. Read More

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December 2018

The necessity of a holistic approach when managing marine mammal-fisheries interactions: Environment and fisheries impact are stronger than seal predation.

Ambio 2018 Dec 8. Epub 2018 Dec 8.

Department of Ecology, Environment and Plant Sciences, Stockholm University, Campus Frescati, Svante Arrhenius väg 20 F, 106 91, Stockholm, Sweden.

Seal populations are recovering in many regions around the world and, consequently, they are increasingly interacting with fisheries. We used an Ecopath with Ecosim model for the offshore Central Baltic Sea to investigate the interactions between the changes in fish stocks and grey seal (Halichoerus grypus) population under different fishing and environmental scenarios for the twenty-first century. The assumed climate, eutrophication and cod (Gadus morhua) fisheries scenarios modified seal predation impacts on fish. Read More

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December 2018

Cellular Metabolism at a Glance.

Exp Suppl 2018 ;109:3-27

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.

Metabolism is highly coordinated component of the cellular activity that involves sequential chemical transformations, within a so-called metabolic network. Through these coordinated actions, living organisms acquire energy and biosynthetic precursors to maintain cellular homeostasis and function. Metabolism relies on the breaking down of macromolecules to produce energy [catabolism] and/or intermediary metabolites that are then used to construct essential building blocks for macromolecule production [anabolism]. Read More

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January 2018

Arthritis pain management: a holistic approach.

Rheumatology (Oxford) 2018 Dec 10. Epub 2018 Dec 10.

Department of Rheumatology, Cambridge University Hospitals, Cambridge, UK.

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December 2018

WHAT ROLES FOR TRACK-STRUCTURE AND MICRODOSIMETRY IN THE ERA OF -omics AND SYSTEMS BIOLOGY?

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

Physics Department, University of Pavia, Pavia, Italy.

Ionizing radiation is a peculiar perturbation when it comes to damage to biological systems: it proceeds through discrete energy depositions, over a short temporal scale and a spatial scale critical for subcellular targets as DNA, whose damage complexity determines the outcome of the exposure. This lies at the basis of the success of track structure (and nanodosimetry) and microdosimetry in radiation biology. However, such reductionist approaches cannot account for the complex network of interactions regulating the overall response of the system to radiation, particularly when effects are manifest at the supracellular level and involve long times. Read More

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December 2018

Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.

Pharmacol Res Perspect 2018 Dec 3;6(6):e00445. Epub 2018 Dec 3.

Department of Medical Sciences Section of Pharmacology National Institute of Neuroscience University of Ferrara Ferrara Italy.

Neuropeptide S (NPS) is the endogenous ligand of the neuropeptide S receptor (NPSR). NPS modulates several biological functions including anxiety, wakefulness, pain, and drug abuse. The aim of this study was the investigation of the pharmacological profile of NPSR using the dynamic mass redistribution (DMR) assay. Read More

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December 2018

Shifting parental roles, caregiving practices and the face of child development in low resource informal settlements of Nairobi: experiences of community health workers and school teachers.

Ann Gen Psychiatry 2018 26;17:50. Epub 2018 Nov 26.

5School of Pharmacy, University of Nairobi, Nairobi, 00200 Kenya.

Approximately, 42% of the Kenyan population live below the poverty line. Rapid growth and urbanization of Kenya's population have resulted in a changing poverty and food security environment in high-density urban areas. Lack of basic food needs in Kenya affects approximately 34. Read More

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November 2018

A Mechanistic View of the Main Current Issues in Photocatalytic CO2 Reduction.

J Phys Chem Lett 2018 Dec 11. Epub 2018 Dec 11.

After 40 years of research on photocatalytic CO2 reduction, there are still many unknowns about its mechanistic aspects even for the most common TiO2-based photocatalytic systems. These uncertainties include the pathways inducing visible-light activity in wide-band-gap semiconductors; the charge transfer between semiconductors and plasmonic metal nanoparticles; the unambiguous determination of the origin of C-bearing products; the very first step in the activation of the CO2 molecule; the factors determining the selectivity; the reasons of photocatalyst deactivation; the closure of the catalytic cycle by the hole-scavenging reagent; and the detailed reaction pathways and the most suitable techniques for their determination. This perspective discusses these controversial issues based on the most relevant investigations reported so far. Read More

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December 2018

The effectiveness of virtual reality training in reducing the risk of falls among elderly people.

Clin Interv Aging 2018 14;13:2329-2338. Epub 2018 Nov 14.

Department of Nursing, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland.

Background: Virtual reality (VR) training using modern game consoles is an innovative rehabilitation method for fall-prone elderly people. The aim of this study was to assess the effectiveness of VR training using the "Xbox 360 Kinect" in people over 60 years of age.

Materials And Methods: The study involved 23 people, including 19 women and 4 men (mean age 75. Read More

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November 2018

Understanding the burden of bacterial sexually transmitted infections and Trichomonas vaginalis among black Caribbeans in the United Kingdom: Findings from a systematic review.

PLoS One 2018 7;13(12):e0208315. Epub 2018 Dec 7.

Institute for Global Health, University College London, London, United Kingdom.

Background: In the UK, people of black Caribbean (BC) ethnicity continue to be disproportionately affected by bacterial sexually transmitted infections (STIs) and Trichomonas vaginalis (TV). We systematically reviewed evidence on the association between bacterial STIs/TV and ethnicity (BC compared to white/white British (WB)) accounting for other risk factors; and differences between these two ethnic groups in the prevalence of risk factors associated with these STIs, sexual healthcare seeking behaviours, and contextual factors influencing STI risk.

Methods: Studies presenting relevant evidence for participants aged ≥14 years and living in the UK were eligible for inclusion. Read More

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December 2018

Establishing Digital Biomarkers for Occupational Health Assessment in Commercial Salmon Fishermen: Protocol for a Mixed-Methods Study.

JMIR Res Protoc 2018 Dec 10;7(12):e10215. Epub 2018 Dec 10.

RTI International, RTP, NC, United States.

Background: Commercial salmon fishing in Alaska is one of the most dangerous occupations in the United States. Between 1992 and 2008, the average annual industry mortality rate was 128 deaths per 100,000 workers, and despite an increase in industry regulations, there has not been a significant decrease in mortality rate since 2000. Unpredictable fishing openings and fierce competition for limited resources result in periods of intense sleep deprivation and physical strain during the short commercial salmon season in Alaska. Read More

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December 2018

Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment: A review.

Environ Res 2018 Nov 26;169:483-493. Epub 2018 Nov 26.

Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China; State Environmental Protection Key Laboratory of Integrated Surface Water-Groundwater Pollution Control, School of Environmental Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

The extensive use of antibiotics leading to the rapid spread of antibiotic resistance poses high health risks to humans, but to date there is still lack of a quantitative model to properly assess the risks. Concerns over the health risk of antibiotic residues in the environment are mainly (1) the potential hazard of ingested antibiotic residues in the environment altering the human microbiome and promoting emergence and selection for bacteria resistance inhabiting the human body, and (2) the potential hazard of creating a selection pressure on environmental microbiome and leading to reservoirs of antibiotic resistance in the environment. We provide a holistic view of health risk assessment of antibiotic resistance associated with antibiotic residues in the environment in contrast with that of the antibiotic resistant bacteria and discuss the main knowledge gaps and the future research that should be prioritized to achieve the quantitative risk assessment. Read More

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November 2018
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