60 results match your criteria Holiday Heart Syndrome

The proarrhythmic conundrum of alcohol intake.

Trends Cardiovasc Med 2021 Mar 21. Epub 2021 Mar 21.

First Department of Cardiology, Athens University School of Medicine, Athens, Greece. Electronic address:

The arrhythmogenic potential of alcohol consumption that leads to cardiac arrhythmia development includes the induction of both atrial and ventricular arrhythmias, with atrial fibrillation (AF) being the commonest alcohol-related arrhythmia, even with low/moderate alcohol consumption. Arrhythmias occur both with acute and chronic alcohol use. The "Holiday Heart Syndrome" relates to the occurrence of AF, most commonly following weekend or public holiday binge drinking; however, other arrhythmias may also occur, including other supraventricular arrhythmias, and occasionally even frequent ventricular premature beats and a rare occurrence of ventricular tachycardia. Read More

View Article and Full-Text PDF

Holiday heart syndrome: an upcoming tachyarrhythmia in today's youth?

Cardiol Young 2021 Feb 9:1-3. Epub 2021 Feb 9.

Division of Pediatric Cardiology, Department of Pediatrics and Adolescence Medicine, Medical University Graz, Graz, Austria.

Atrial fibrillation is one of the most common arrhythmias in the adult population, in children, however, only a few case reports of isolated atrial fibrillation exist.1 Aside from post-operative AF due to atrial scar formation or suture lines and atrial enlargement in CHD (e.g. Read More

View Article and Full-Text PDF
February 2021

Acute electrical, autonomic and structural effects of binge drinking: Insights into the 'holiday heart syndrome'.

Int J Cardiol 2021 05 3;331:100-105. Epub 2021 Feb 3.

Heart Centre, The Alfred Hospital, Melbourne, Australia; Baker Heart & Diabetes Institute, Melbourne, Australia; Department of Cardiology, Cabrini Hospital, Melbourne, Australia; Department of Medicine, University of Melbourne, Melbourne, Australia; Department of Medicine, Monash University, Melbourne, Australia. Electronic address:

Background: Binge drinking is a common atrial fibrillation (AF) trigger, however the mechanisms are poorly understood.

Objective: To investigate the effects of alcohol intoxication and hangover with rhythm monitoring and cardiac MRI.

Methods: Patients underwent serial cardiac MRI pre- and post-binge with continuous Holter monitoring. Read More

View Article and Full-Text PDF

Depolarization of the Rat Atria in Experimental Simulation of the Holiday Heart Syndrome.

Dokl Biochem Biophys 2020 Nov 25;495(1):304-306. Epub 2020 Dec 25.

Zakusov Research Institute of Pharmacology, Moscow, Russia.

In the study of the sequence of depolarization of the atrial subepicardium of rats in the short-term alcohol consumption model (the "Holiday heart" syndrome), the localization of the sources of atrial arrhythmias was determined for the first time. The difference in the excitation of the right and left atria was discovered: the right atrium is activated anterogradely from the sinoatrial node, whereas the left atrium is activated retrogradely from the ectopic focus located in the left auricular appendage. Read More

View Article and Full-Text PDF
November 2020

Causal roles of stress kinase JNK2 in DNA methylation and binge alcohol withdrawal-evoked behavioral deficits.

Pharmacol Res 2021 02 11;164:105375. Epub 2020 Dec 11.

Department of Physiology & Biophysics, Rush University Medical Center, Chicago, IL, 60607, USA. Electronic address:

Excessive binge alcohol intake is a common drinking pattern in humans, especially during holidays. Cessation of the binge drinking often leads to aberrant withdrawal behaviors, as well as serious heart rhythm abnormalities (clinically diagnosed as Holiday Heart Syndrome (HHS)). In our HHS mouse model with well-characterized binge alcohol withdrawal (BAW)-induced heart phenotypes, BAW leads to anxiety-like behaviors and cognitive impairment. Read More

View Article and Full-Text PDF
February 2021

Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3β (GSK3β) / Nuclear Factor of Activated T-Cells (NFAT) Signaling - An Experimental Account of Holiday Heart Syndrome.

Circ J 2020 10 7;84(11):1931-1940. Epub 2020 Oct 7.

Department of Pathophysiology, Oita University School of Medicine.

Background: The association between binge alcohol ingestion and atrial fibrillation (AF), often termed "holiday heart syndrome", has long been recognized. However, the underlying cellular and molecular mechanisms are unknown.Methods and Results:An experimental model of binge alcohol-induced AF was developed to elucidate the mechanisms linking acute ethanol exposure to changes in ion channel transcription and AF susceptibility. Read More

View Article and Full-Text PDF
October 2020

Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses.

J Mol Cell Cardiol 2020 09 22;146:69-83. Epub 2020 Jul 22.

Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University, the Netherlands. Electronic address:

Acute excessive ethyl alcohol (ethanol) consumption alters cardiac electrophysiology and can evoke cardiac arrhythmias, e.g., in 'holiday heart syndrome'. Read More

View Article and Full-Text PDF
September 2020

Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia.

J Am Coll Cardiol 2018 04;71(13):1459-1470

Department of Physiology and Biophysics, Rush University Medical Center, Chicago, Illinois; Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, Illinois. Electronic address:

Background: Excessive binge alcohol drinking has acute cardiac arrhythmogenic effects, including promotion of atrial fibrillation (AF), which underlies "Holiday Heart Syndrome." The mechanism that couples binge alcohol abuse with AF susceptibility remains unclear. We previously reported stress-activated c-Jun N-terminal kinase (JNK) signaling contributes to AF development. Read More

View Article and Full-Text PDF

SR Ca-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure.

J Mol Cell Cardiol 2018 03 3;116:81-90. Epub 2018 Feb 3.

Dept. of Internal Medicine II, University Medical Center Regensburg, Regensburg, Germany. Electronic address:

Aims: Ethanol has acute negative inotropic and arrhythmogenic effects. The underlying mechanisms, however, are largely unknown. Sarcoplasmic reticulum Ca-leak is an important mechanism for reduced contractility and arrhythmias. Read More

View Article and Full-Text PDF

Round-the-clock performance of coronary CT angiography for suspected acute coronary syndrome: Results from the BEACON trial.

Eur Radiol 2018 May 15;28(5):2169-2175. Epub 2017 Dec 15.

Department of Cardiology, Erasmus University Medical Center, Room: Ca-207a, 's-Gravendijkwal 230, Rotterdam, 3015 CE, The Netherlands.

Objective: To assess the image quality of coronary CT angiography (CCTA) for suspected acute coronary syndrome (ACS) outside office hours.

Methods: Patients with symptoms suggestive of an ACS underwent CCTA at the emergency department 24 hours, 7 days a week. A total of 118 patients, of whom 89 (75 %) presented during office hours (weekdays between 07:00 and 17:00) and 29 (25 %) outside office hours (weekdays between 17:00 and 07:00, weekends and holidays) underwent CCTA. Read More

View Article and Full-Text PDF

Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW).

Eur Heart J 2017 Jul;38(27):2100-2106

Department of Medicine I, University Hospital Munich, Ludwig Maximilians University, Marchioninistr. 15, 81377 Munich, Germany.

Aims: Alcohol is a risk factor for cardiac arrhythmias. Retrospective analyses suggest supraventricular arrhythmias consecutive to acute alcohol consumption, but prospective data are limited. We intended to prospectively associate acute alcohol consumption with cardiac arrhythmias. Read More

View Article and Full-Text PDF

Acute Abdominal Aorta Thrombosis and Ischemic Rhabdomyolysis Secondary to Severe Alcohol Intoxication.

Cureus 2016 Dec 1;8(12):e905. Epub 2016 Dec 1.

Department of Nephrology, Shifa International Hospital, Islamabad, Pakistan.

Acute alcohol intoxication is a common cause of emergency visits worldwide. Although moderate alcohol consumption is protective against coronary artery disease, binge drinking is associated with adverse cardiovascular and neurological outcomes and may even cause sudden death. Although, few past accounts of venous thrombosis with alcohol binge drinking are available, arterial thrombosis with the condition has never been reported in the literature. Read More

View Article and Full-Text PDF
December 2016

Alcohol and Atrial Fibrillation: A Sobering Review.

J Am Coll Cardiol 2016 Dec;68(23):2567-2576

Alfred Heart Centre, Alfred Hospital, Melbourne, Victoria, Australia; Baker IDI Heart and Diabetes Research Institute, Melbourne, Victoria, Australia; University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Alcohol is popular in Western culture, supported by a perception that modest intake is cardioprotective. However, excessive drinking has detrimental implications for cardiovascular disease. Atrial fibrillation (AF) following an alcohol binge or the "holiday heart syndrome" is well characterized. Read More

View Article and Full-Text PDF
December 2016

[Alcohol and arrhythmias].

Herz 2016 Sep;41(6):498-502

Abt. Kardiologie & Angiologie, Department für Innere Medizin, Neurologie und Dermatologie, Universität Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland.

The effects of alcohol on induction of arrhythmias is dose-dependent, independent of preexisting cardiovascular diseases or heart failure and can affect otherwise healthy subjects. While the probability of atrial fibrillation increases with the alcohol dosage, events of sudden cardiac death are less frequent with low and moderate consumption but occur more often in heavy drinkers with alcoholic cardiomyopathy. Men are first affected at higher dosages of alcohol but women can suffer from arrhythmias at lower dosages. Read More

View Article and Full-Text PDF
September 2016

[Alcohol consumption in women and the elderly : When does it induce heart failure?].

S Pankuweit

Herz 2016 Sep;41(6):494-7

Klinik für Innere Medizin - Kardiologie, Philipps-Universität Marburg, Baldingerstraße, 35043, Marburg, Deutschland.

The association between alcohol consumption and the etiology and prognosis of cardiovascular diseases has been the focus of attention and also the subject of controversial discussions for many years. This is particularly true for heart failure, which can be induced by coronary artery disease (CAD), arterial hypertension, atrial and ventricular arrhythmias and cardiomyopathies. Acute effects of high doses of alcohol can lead to impairment of the cardiac contraction strength with rhythm disturbances (holiday heart syndrome), transient ischemic attacks and in rare cases to sudden cardiac death. Read More

View Article and Full-Text PDF
September 2016

A Heart too Drunk to Drive; AV Block following Acute Alcohol Intoxication.

Chin J Physiol 2016 02;59(1):1-8

Department of Medical Physiology, Division of Heart & Lungs, University Medical Center Utrecht, Yalelaan 50, 3584 CM Utrecht, The Netherlands.

Acute excessive alcohol consumption is associated with heart rhythm disorders like atrial fibrillation but also premature ventricular contractions, collectively known as the "holiday heart syndrome". More rarely but clinically significant are reports of atrioventricular (AV) conduction disturbances in binge drinkers with no underlying heart disease or chronic alcohol consumption. To obtain better insights into common denominators and the potential underlying mechanisms we collected and compared individual case reports of AV block following acute alcohol intoxication in otherwise healthy people. Read More

View Article and Full-Text PDF
February 2016

Holiday heart syndrome.

Am J Crit Care 2014 Mar;23(2):171-2

Mary G. Carey is associate director for clinical nursing research, Strong Memorial Hospital, Rochester, New York. Salah S. Al-Zaiti is an assistant professor at the Acute and Tertiary Care Department, University of Pittsburgh, Pennsylvania. Teri Kozik is supervisor of cardiac research at St. Joseph's Medical Center, Stockton, California. Michele M. Pelter is an assistant professor at the Orvis School of Nursing, University of Nevada, Reno.

View Article and Full-Text PDF

Holiday heart syndrome revisited after 34 years.

Arq Bras Cardiol 2013 Aug;101(2):183-9

The cardiovascular effects of alcohol are well known. However, most research has focused on the beneficial effects (the "French paradox") of moderate consumption or the harmful consequences, such as dilated cardiomyopathy, associated with heavy consumption over an extended period. An association between the ingestion of acute alcohol and onset of cardiac arrhythmias was first reported in the early 70's. Read More

View Article and Full-Text PDF

Are acute coronary syndrome patients admitted during off-duty hours treated differently? An analysis of the Saudi Project for Assessment of Acute Coronary Syndrome (SPACE) study.

Ann Saudi Med 2012 Jul-Aug;32(4):366-71

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background And Objectives: It is often suggested that acute coronary syndrome (ACS) patients admitted during off-duty hours (OH) have a worse clinical outcome than those admitted during regular working hours (RH). Our objective was to compare the management and hospital outcomes of ACS patients admitted during OH with those admitted during RH.

Design And Setting: Prospective observational study of ACS patients enrolled in the Saudi Project for Assessment of Acute Coronary Syndrome study from December 2005 to December 2007. Read More

View Article and Full-Text PDF
November 2012

The Estimated Risk of Atrial Fibrillation Related to Alcohol Consumption.

J Atr Fibrillation 2012 Jun-Jul;5(1):424. Epub 2012 Jun 15.

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA, USA.

The risk of acute heavy alcohol intake on the development of atrial fibrillation (AF), aka ?holiday heart syndrome?, has been well-described. However, whether chronic alcohol intake is also associated with increased risk of AF, or might even be protective as has been observed with other cardiac conditions, is more uncertain. A number of studies, from basic science to large cohort studies have been performed to analyze the association between alcohol and AF. Read More

View Article and Full-Text PDF

Effects of weather variability and air pollutants on emergency admissions for cardiovascular and cerebrovascular diseases.

Int J Environ Health Res 2012 5;22(5):416-30. Epub 2012 Mar 5.

Department of Preventive Medicine and Public Health , Shinshu University School of Medicine, Matsumoto, Japan.

We examined the effect of ambient temperature, air pressure and air pollutants on daily emergency admissions by identifying the cause of admission for each type of stroke and cardiovascular disease using generalized linear Poisson regression models allowing for overdispersion, and controlling for seasonal and inter-annual variations, days of the week and public holidays, levels of influenza and respiratory syncytial viruses. Every 1°C decrease in mean temperature was associated with an increase in the daily number of emergency admissions by 7.83% (95% CI 2. Read More

View Article and Full-Text PDF
January 2013

Syndromes of "holiday heart".

J Emerg Nurs 2011 Nov;37(6):577-9

St. Joseph’s Hospital, St. Paul, MN 55120, USA.

View Article and Full-Text PDF
November 2011

Acute altitude induced hypoxia in a child with Down's syndrome following postoperative repair of complete atrioventricular septal defect.

BMJ Case Rep 2011 Apr 13;2011. Epub 2011 Apr 13.

Northern Deanery, Newcastle-Upon-Tyne, UK.

The authors report the case of a 4-year-old male child with a background of Down's syndrome (Trisomy 21) and a definitive repair of a balanced complete atrioventricular septal defect (CAVSD) at 3 months of age who experienced acute pulmonary oedema at high altitude (2000 m) while on holiday with his parents. The authors discuss and review the literature on the effect of altitude on children with Down's syndrome and postoperative CAVSD repair. The authors propose that further research is needed into this area in this specific group of patients, so advice can be given to families prior to flying or travelling. Read More

View Article and Full-Text PDF

Austrian Moderate Altitude Studies (AMAS): benefits of exposure to moderate altitudes (1,500-2,500 m).

Sleep Breath 2010 Sep 11;14(3):201-7. Epub 2009 Aug 11.

Institut für Sport-, Alpinmedizin und Gesundheitstourismus (ISAG), TILAK Innsbruck und UMIT, Eduard Wallnöfer-Zentrum 1, Hall/Tirol, Austria.

Objectives: A considerable part of the millions of Alpine tourists suffer from pre-existing diseases (e.g., metabolic syndrome) and high daily stress levels. Read More

View Article and Full-Text PDF
September 2010

[Continuous analysis of heart rate variability for examination of cardiac autonomic nervous system after alcohol intoxication].

Med Klin (Munich) 2009 Jul 18;104(7):511-9. Epub 2009 Jul 18.

Medizinische Klinik I, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck.

Background: Alcohol intoxication is associated with deterioration of cardiac nervous function and increased mortality.

Patients And Methods: Therefore, 14 patients (eight male, six female; 24-59 years) with pure ethanol intoxication and toxic levels of 210-520 mg/dl in the blood were prospectively investigated. For evaluation of changes in sympathetic and vagal modulation, an analysis of heart rate variability (HRV) was performed. Read More

View Article and Full-Text PDF

Alcohol-induced electrical remodeling: effects of sustained short-term ethanol infusion on ion currents in rabbit atrium.

Alcohol Clin Exp Res 2009 Oct 1;33(10):1697-703. Epub 2009 Jul 1.

Department of Cardiology, University of Tuebingen, Tuebingen, Germany.

Background: In some patients, above-average alcohol consumption before occurrence of atrial fibrillation (AF) in terms of a "holiday heart syndrome" (HHS) can be determined. There is evidence that long before development of apparent alcohol-induced cardiomyopathy, above-average alcohol consumption generates an arrhythmogenic substrate which abets the onset of AF. Changes of atrial current densities in terms of an electrical remodeling after sustained short-term ethanol infusion in rabbits as a potential part of HHS pathophysiology were examined in this study. Read More

View Article and Full-Text PDF
October 2009

Purim CPR.

Psychosom Med 2009 Jan 5;71(1):6-13. Epub 2009 Jan 5.

Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520-8017, USA.

View Article and Full-Text PDF
January 2009

Effects of alcohol on atrial fibrillation: myths and truths.

Ther Adv Cardiovasc Dis 2009 Feb 21;3(1):53-63. Epub 2008 Aug 21.

Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil.

Alcohol is the most consumed drug worldwide. Both acute and chronic alcohol use have been associated with cardiac arrhythmias, in particular atrial fibrillation, or so-called 'holiday heart syndrome'. Epidemiological, clinical and experimental studies have attempted to elucidate the mechanisms involved in this association. Read More

View Article and Full-Text PDF
February 2009