45,127 results match your criteria Hokkaido Journal of Medical Science Hokkaido Igaku Zasshi[Journal]


Associations between cognitive impairment and quality of life in euthymic bipolar patients.

Psychiatry Res 2018 Nov 26;271:510-515. Epub 2018 Nov 26.

Department of Psychiatry, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

During the euthymic state in bipolar disorder, cognitive functions often remain affected. Specifically, subjective and objective cognitive impairment might distinctly affect patients' quality of life (QoL); however, this question had not been examined previously in Japanese patients. Therefore, the current study investigated the associations between cognitive complaints, QoL, and objective cognitive functions. Read More

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November 2018
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Associations of Patient Experience in Primary Care With Hospitalizations and Emergency Department Visits on Isolated Islands: A Prospective Cohort Study.

J Rural Health 2018 Dec 14. Epub 2018 Dec 14.

Department of Family and Community Medicine, Hamamatsu University School of Medicine, Higashi-ku, Hamamatsu, Shizuoka, Japan.

Purpose: In rural areas, the management of hospitalizations and emergency department (ED) visits is an important issue, and it is compounded by factors such as the long distance to secondary care facilities, funding difficulties in many rural medical institutions, and shortage of medical staff. While better patient experience (PX) has been shown to reduce hospitalizations and ED visits, previous studies have not considered the differences between urban and rural areas. In addressing this gap, this study examines the association between PX and hospitalizations/ED visits on isolated islands. Read More

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December 2018

Second Harmonic Light Manipulation with Vertical Split Ring Resonators.

Adv Mater 2018 Dec 14:e1806479. Epub 2018 Dec 14.

Research Center for Applied Sciences, Academia Sinica, Taipei, 11529, Taiwan.

The second harmonic generation (SHG) of vertical and planar split-ring resonators (SRRs) that are broken centro-symmetry configurations at the interface of metal surface and air is investigated. Strong interactions, better electromagnetic field confinements, and less leakage into the substrate for vertical SRRs are found. Experimental results show a 2. Read More

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December 2018

Impact of ALBI grade on survival in patients with HCC who received sorafenib: an analysis using time-dependent ROC.

J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Epidemiology, Infectious Disease Control, and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima, Hiroshima, Japan.

Background And Aims: Albumin-bilirubin (ALBI) grade was developed as a new method to assess hepatic function. Sorafenib has been confirmed to be effective in improving survival in patients with advanced hepatocellular carcinoma (HCC). In this study, we investigated the impact of ALBI grade versus Child-Pugh classification on survival in HCC patients who received sorafenib. Read More

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December 2018

Analysis of radio-sensitivity of cancer stem-like cells derived from canine cancer cell lines.

Vet Comp Oncol 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.

Cancer stem-like cells (CSCs) are self-renewing cells comprising a small subpopulation in tumors, and generate differentiated progeny via asymmetric division. It has been shown that CSCs are resistant to ionizing radiation, and this feature could be one of the mechanisms of tumor recurrence after radiation therapy. Much attention has been focused on to target CSCs; however, difficulty of isolating CSCs and lack of knowledge on their radiosensitivity have limited this kind of research in veterinary medicine. Read More

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December 2018

A Polystyrene-Cross-Linking Tricyclohexylphosphine: Synthesis, Characterization and Applications to Pd-Catalyzed Cross-Coupling Reactions of Aryl Chlorides.

Chem Asian J 2018 Dec 12. Epub 2018 Dec 12.

JAPAN.

A polystyrene-cross-linking tricyclohexylphosphine (PS-TCP) was synthesized through radical emulsion polymerization of 4-t-butylstyrene as a monomer and tris(trans-4-styrylcyclohexyl)phosphine as a three-fold cross-linker. The PS-TCP showed enhanced ligand performance compared to the corresponding polystyrene-triphenylphosphine hybrid PS-TPP and tricyclohexylphosphine in Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions of aryl chlorides. Read More

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December 2018

Editorial Comment to Long-term safety and efficacy of antimuscarinic add-on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study).

Authors:
Takeya Kitta

Int J Urol 2018 Dec 13. Epub 2018 Dec 13.

Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

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December 2018

Two Consecutive Polar Amino Acids at the End of Helix E are Important for Fast Turnover of the Archaerhodopsin Photocycle.

Photochem Photobiol 2018 Dec 12. Epub 2018 Dec 12.

Division of Engineering, Muroran Institute of Technology, Muroran, 050-8585, Japan.

Archaerhodopsins (ARs) is one of the members of microbial rhodopsins. Threonine 164 (T164) and serine 165 (S165) residues of the AR from Halorubrum sp. ejinoor (HeAR) are fully conserved in ARs, although they are far from the proton transfer channel and the retinal Schiff base, and are likely involved in a hydrogen bonding network at the end of the Helix E where most microbial rhodopsins assume a "bent structure". Read More

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December 2018

Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma.

J Surg Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Clinical Oral Oncology, Hokkaido Cancer Center, Sapporo, Japan.

Background And Objectives: Some patients with early-stage oral cancer have a poor prognosis owing to the delayed neck metastasis (DNM). Tumor budding is reportedly a promising prognostic marker in many cancers. Moreover, the tissue surrounding a tumor is also considered to play a prognostic role. Read More

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December 2018

Canine non-epitheliotropic CD4-positive cutaneous T-cell lymphoma: a case report.

Vet Med Sci 2018 Dec 12. Epub 2018 Dec 12.

Synergy Animal General Hospital, Kawaguchi, Saitama, Japan.

A 5-year-old, spayed female French Bulldog presented with multiple papules on the skin of the scapular area. Histopathological examination of punch biopsy samples revealed dense infiltration of small lymphoid cells in the superficial dermis and in areas surrounding hair follicles. Immunohistochemical analysis indicated that these cells were positive for CD3, CD4, and TCRαβ, but negative for CD1c, CD8α, CD8β, CD11c, CD20, CD45RA, CD90, MHC-II, and TCRγδ. Read More

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December 2018
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A Covalent Inhibitor for Glutathione S-Transferase Pi (GSTP1-1) in Human Cells.

Chembiochem 2018 Dec 7. Epub 2018 Dec 7.

Nagoya University, Department of Chemistry, Graduate School of Science, Furo, Chikusa, 464-8602, Nagoya, JAPAN.

Glutathione S-transferases (GSTs) are overexpressed in several cancers and are involved in drug resistance. Therefore, GSTs are an important target in cancer therapy and many GST inhibitors have been reported. We have developed an irreversible inhibitor, GS-ESF, as an effective GST inhibitor. Read More

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December 2018

Ice-binding proteins from the fungus Antarctomyces psychrotrophicus possibly originate from two different bacteria through horizontal gene transfer.

FEBS J 2018 Dec 10. Epub 2018 Dec 10.

Graduate School of Life Science, Hokkaido University, Sapporo, 060-0810, Japan.

Various microbes, including fungi and bacteria, that live in cold environments produce ice-binding proteins (IBPs) that protect them from freezing. Ascomycota and Basidiomycota are two major phyla of fungi, and Antarctomyces psychrotrophicus is currently designated as the sole ascomycete that produces IBP (AnpIBP). However, its complete amino acid sequence, ice-binding property, and evolutionary history have not yet been clarified. Read More

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December 2018

Surgical repair of severe mitral valve regurgitation complicated by incomplete cor triatriatum.

J Cardiol Cases 2014 Jan 13;9(1):29-31. Epub 2013 Dec 13.

Department of Cardiology, KKR Sapporo Medical Center, Hiragishi 1-6, Toyohira-ku, Sapporo, Hokkaido 062-0931, Japan.

A 69-year-old woman with exertional dyspnea was referred emergently to our hospital for further evaluation. Transthoracic echocardiography showed severe mitral valve regurgitation and moderate tricuspid regurgitation, which were thought to be the main cause of her heart failure. An electrocardiogram showed paroxysmal atrial fibrillation. Read More

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January 2014

Successful adaptive servo-ventilation for patients with acute cardiogenic pulmonary edema due to severe aortic stenosis.

J Cardiol Cases 2010 Oct 12;2(2):e115-e118. Epub 2010 Jun 12.

Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.

A 60-year-old woman with severe aortic stenosis (AS) and congenital bicuspid aortic valve was admitted to our hospital due to cardiogenic pulmonary edema. Noninvasive adaptive servo-ventilation (ASV) improved her symptoms and respiratory status. It was associated with favorable hemodynamic effects including an increase in cardiac output and a decrease in pulmonary vascular resistance without alternating systemic blood pressure. Read More

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October 2010

Long-term echocardiographic evaluation of valvular lesions in a patient with nonbacterial thrombotic endocarditis associated with advanced uterine cancer.

J Cardiol Cases 2016 Sep 2;14(3):82-86. Epub 2016 Jun 2.

Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Nonbacterial thrombotic endocarditis (NBTE) is characterized by the deposition of thrombi on previously undamaged heart valves in the absence of bacteremia and predominantly affects patients with hypercoagulable state. Although the diagnosis is usually based on transthoracic echocardiography, little is known about the serial changes of the vegetation in response to treatment. We experienced a 42-year-old woman with advanced uterine cancer and asymptomatic cerebral embolization. Read More

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September 2016

Eosinophilic myocarditis without hypereosinophilia accompanied by giant cell infiltration.

J Cardiol Cases 2015 Nov 4;12(5):169-171. Epub 2015 Aug 4.

Cardiovascular, Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.

A 53-year-old woman with a history of allergic disease was admitted to our hospital because of syncope induced by sustained ventricular tachycardia. The clinical course and the laboratory data did not correspond to those of acute myocarditis. Although eosinophils in the peripheral blood count were not increased, the diagnosis of eosinophilic myocarditis was made following a right ventricular endomyocardial biopsy that showed a remarkable infiltration of eosinophils. Read More

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November 2015

Aortic valve aneurysm responsible for acute congestive heart failure and histological findings: A case report.

J Cardiol Cases 2014 Sep 25;10(3):100-103. Epub 2014 Jun 25.

Department of Cardiology, Hakodate Goryokaku Hospital, Hakodate, Hokkaido, Japan.

We experienced a case of acute congestive heart failure in a 73-year-old man who had been followed up due to mild-to-moderate aortic stenosis and moderate-to-severe aortic regurgitation. A huge aortic valve aneurysm was found to extend from his right coronary cusp to a left ventricular outflow tract, resulting in moderate subaortic obstruction and severe aortic regurgitation. Surgical repair was performed and a perforated aneurysm of right aortic cusp was identified. Read More

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September 2014

Contamination Levels and Sources of Heavy Metals and a Metalloid in Surface Soils in the Kumasi Metropolis, Ghana.

J Health Pollut 2017 Sep 7;7(15):28-39. Epub 2017 Sep 7.

Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060-0818, Japan.

Background: Environmental contamination with heavy metals and metalloids due to industrial, smelting and mining activities have become common in large and growing cities. Kumasi is one of the most industrialized cities in Ghana and experiences metal pollution due to recent and past activities. Although metals are naturally abundant in the area, their accumulation in soils could potentially lead to adverse effects on local ecosystems. Read More

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September 2017

A thermostable trypsin from freshwater fish Japanese dace (Tribolodon hakonensis): a comparison of the primary structures among fish trypsins.

Fish Physiol Biochem 2018 Dec 13. Epub 2018 Dec 13.

Laboratory of Marine Chemical Resource Development, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido, 041-8611, Japan.

Trypsin from Japanese dace (Tribolodon hakonensis) (JD-T) living in freshwater (2-18 °C) was purified. JD-T represented typical fish trypsin characteristics regarding the effects of protease inhibitor, calcium-ion, and pH. For the effect of temperature, JD-T quite resembled to the trypsins from tropical-zone marine fish and freshwater fish (the catfish cultured in Thailand), i. Read More

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December 2018

Development of a microdevice for facile analysis of theophylline in whole blood by a cloned enzyme donor immunoassay.

Lab Chip 2018 Dec 14. Epub 2018 Dec 14.

Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan and ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan and Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu 761-0395, Japan.

We have developed a microdevice for therapeutic drug monitoring. In this device, dispensing of sample and reagent was accomplished by simple manual operation of a syringe. Moreover, for a simple and rapid measurement, we used cloned enzyme donor immunoassay as a detection principle. Read More

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December 2018

Segmental replacement to treat abdominal aortic aneurysm with bilateral accessory renal artery.

J Vasc Surg Cases Innov Tech 2018 Dec 4;4(4):305-306. Epub 2018 Dec 4.

Department of Cardiovascular Surgery, Hokkaido Prefectural Kitami Hospital, Kitami, Hokkaido, Japan.

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December 2018

Effects of Remnant Tissue Preservation on Tunnel Enlargement After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction Using the Hamstring Tendon.

Orthop J Sports Med 2018 Dec 6;6(12):2325967118811293. Epub 2018 Dec 6.

Sports Medicine and Arthroscopy Center, Yagi Orthopaedic Hospital, Sapporo, Japan.

Background: The effects of remnant tissue preservation on tunnel enlargement after anatomic double-bundle anterior cruciate ligament (ACL) reconstruction have not yet been established.

Hypothesis: The preservation of ACL remnant tissue may significantly reduce the degree and incidence of tunnel enlargement after anatomic double-bundle ACL reconstruction, while the remnant-preserving procedure may not significantly increase the incidence of tunnel coalition after surgery.

Study Design: Cohort study; Level of evidence, 2. Read More

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December 2018

Enrichment and Genomic Characterization of a NO-Reducing Chemolithoautotroph From a Deep-Sea Hydrothermal Vent.

Front Bioeng Biotechnol 2018 28;6:184. Epub 2018 Nov 28.

Laboratory of Microbiology, Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Japan.

Nitrous oxide (NO) is a greenhouse gas and also leads to stratospheric ozone depletion. In natural environments, only a single NO sink process is the microbial reduction of NO to N, which is mediated by nitrous oxide reductase (NosZ) encoded by gene. The phylogeny has two distinct clades, clade I and formerly overlooked clade II. Read More

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November 2018

Targeted next-generation sequencing of cancer-related genes in thyroid carcinoma: A single institution's experience.

Oncol Lett 2018 Dec 2;16(6):7278-7286. Epub 2018 Oct 2.

Department of Biology and Genetics, Laboratory of Cancer Medical Science, Hokuto Hospital, Obihiro, Hokkaido 080-0833, Japan.

Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in next-generation sequencing (NGS) technology enable simultaneous analysis of cancer-associated genes of interest, thus improving diagnostic accuracy and allowing precise personalized treatment for human cancer. A total of 50 patients who underwent thyroidectomy between 2014 and 2016 at Hokuto Hospital were enrolled. Read More

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December 2018

Rare case of idiopathic sclerosing cholangitis, which was difficult to distinguish from cholangiocarcinoma: A case report.

Exp Ther Med 2018 Dec 5;16(6):5224-5226. Epub 2018 Oct 5.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan.

It is often difficult to correctly diagnose patients who present with dilation of the bile duct. Cholangiocarcinoma, primary sclerosing cholangitis (PSC) and immunoglobulin (Ig)G4-related sclerosing cholangitis must be considered as potential diagnoses for these cases. The current study presents a 73-year-old female patient who presented with a high fever and abdominal pain. Read More

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December 2018

Anti-TIF1γ antibody predicted malignancy of thymic tumor with dermatomyositis as an "autoimmune tumor marker": A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13563

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Rationale: An association between inflammatory myopathy and malignancy has been recognized particularly in patients positive for anti-transcription intermediary factor 1γ (TIF1γ) antibody. We report a case of anti-TIF1γ antibody positive dermatomyositis (DM) associated with thymic carcinoma which radiographically mimicked benign tumor.

Patient Concerns: A 72-year-old man presented typical characteristic cutaneous manifestations and proximal muscle weakness with elevated levels of myogenic enzymes. Read More

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December 2018

[Urinary Retention Caused by Necrotic Tissues in the Bladder of a Female Recipient of a Living-Donor Kidney Transplant : A Case Report].

Hinyokika Kiyo 2018 Oct;64(10):409-413

The Department of Kidney Transplant Surgery, Sapporo City General Hospital.

We report a patient who developed urinary retention due to the presence of necrotic tissues in the bladder 5 months after kidney transplantation. The patient was a 47-year-old female who had been diagnosed with immunoglobulin A nephropathy. She requested to receive a living-donor kidney transplant from her husband, and was referred to our hospital. Read More

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October 2018

Preliminary investigation of ixodid ticks in Jiangxi Province of Eastern China.

Exp Appl Acarol 2018 Dec 12. Epub 2018 Dec 12.

Nanchang Center for Disease Control and Prevention, Nanchang, 330038, Jiangxi, People's Republic of China.

In recent years, a large effort has been made for tick surveys for public health importance around China, especially after outbreaks of severe fever with thrombocytopenia syndrome (SFTS) occurred in humans in 2009. In this paper, the preliminary species composition and population distribution of ticks in Jiangxi Province of Eastern China is reported. Ticks were collected in three habitats (grassland, shrubs and woodland) and from nine host groups in 12 sampling sites throughout Jiangxi Province between 2011 and 2018. Read More

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December 2018

Direct synthesis of aryl-annulated []carbazoles by gold(i)-catalysed cascade reaction of azide-diynes and arenes.

Chem Sci 2018 Nov 10;9(44):8416-8425. Epub 2018 Sep 10.

Graduate School of Pharmaceutical Sciences , Kyoto University , Sakyo-ku , Kyoto 606-8501 , Japan . Email:

The gold-catalysed annulation of conjugated alkynes bearing an azido group with arenes gave annulated []carbazoles. Using benzene, pyrrole, and indole derivatives as the nucleophiles, benzo[]-, pyrrolo[2,3-]-, and indolo[2,3-]carbazoles were produced, respectively. The reaction proceeded through pyrrole and benzene ring construction accompanied by the formation of two carbon-carbon and one carbon-nitrogen bond and the cleavage of two aromatic C-H bonds. Read More

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November 2018

Pathogenesis and therapeutic interventions for ANCA-associated vasculitis.

Nat Rev Rheumatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects systemic small vessels and is accompanied by the presence of ANCAs in the serum. This disease entity includes microscopic polyangiitis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and drug-induced AAV. Similar to other autoimmune diseases, AAV develops in patients with a predisposing genetic background who have been exposed to causative environmental factors. Read More

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December 2018

Prevention of Fish Oil Oxidation.

Authors:
Kazuo Miyashita

J Oleo Sci 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Fisheries Sciences, Hokkaido University.

The benefit of fish oil to health has been widely recognized because of the high contents of functional EPA (20:5n-3) and DHA (22:6n-3) in the oil; however, the application of fish oil has been limited by its high susceptibility to oxidation. This review reports the characteristics of EPA and DHA oxidation compared with those of other fatty acids such as linoleic acid (18:2n-6). In addition, effective approaches to protect against oxidation are discussed, focusing on the unique antioxidant potential of amine compounds. Read More

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December 2018

Effects of pastes containing ion-releasing particles on dentin remineralization.

Dent Mater J 2018 Dec 11. Epub 2018 Dec 11.

Division of Orthodontics and Dentofacial Orthopedics, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido.

We investigated the effects of the weekly application of pastes containing a surface reaction-type pre-reacted glass-ionomer (S-PRG) filler on dentin remineralization. Human dentin blocks were demineralized and polished using pastes containing S-PRG filler (0, 5, and 30%), and then immersed in remineralizing solution for 1 month. Nanoindentation testing was carried out during the immersion period, and the dentin surfaces were examined using scanning electron microscopy. Read More

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December 2018

Splicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein Isoforms.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Laboratory of RNA Viruses, Department of Virus Research, Institute for Frontier Life and Medical Sciences (inFront), Kyoto University, Kyoto 606-8507.

Targeting of viral proteins to specific subcellular compartments is a fundamental step for viruses to achieve successful replication in infected cells. Borna disease virus-1 (BoDV), a non-segmented, negative-strand RNA virus, uniquely replicates and persists in the cell nucleus. Here, it is demonstrated that BoDV nucleoprotein (N) transcripts undergo mRNA splicing to generate truncated isoforms. Read More

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December 2018

Urinary Exosome-Derived microRNAs Reflecting the Changes in Renal Function in Cats.

Front Vet Sci 2018 20;5:289. Epub 2018 Nov 20.

Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Increased incidence of kidney disease (KD) is a common concern in human and companion animals. Cats, in particular, are highly susceptible to KD. Novel KD biomarkers would help to address these problems. Read More

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November 2018

Characterization, Spatial Variation and Risk Assessment of Heavy Metals and a Metalloid in Surface Soils in Obuasi, Ghana.

J Health Pollut 2018 Sep 20;8(19):180902. Epub 2018 Aug 20.

Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060-0818, Japan.

Background: Soil contamination with heavy metals and metalloids has become an increasingly important issue in recent years.

Objectives: The present study examines possible contamination of the environment with metals from gold mining activities in Obuasi, Ghana.

Methods: Soil samples were collected from commercial and residential areas and tailing dams in Obuasi in order to investigate the extent of lead (Pb), cadmium (Cd), mercury (Hg), copper (Cu), zinc (Zn), cobalt (Co), chromium (Cr), nickel (Ni) and arsenic (As) pollution, create thematic maps showing the extent of heavy metals pollution, identify the sources of pollution, and to assess risks to humans and the surrounding ecological system. Read More

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September 2018

Standardization of nitric oxide inhalation in extremely preterm infants in Japan.

Pediatr Int 2018 Dec 6. Epub 2018 Dec 6.

Neonatal Intensive Care, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.

Background: In perinatal medicine, inhaled nitric oxide (iNO) has been an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn (PPHN) and hypoxemic respiratory failure (HRF). However, its use in more premature infants is controversial. To evaluate the current clinical practices regarding use of acute inhaled nitric oxide (iNO) therapy in extremely preterm infants, a nationwide survey was conducted in Japan. Read More

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December 2018

Impact of admission liver stiffness on long-term clinical outcomes in patients with acute decompensated heart failure.

Heart Vessels 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, kita-ku, Sapporo, Hokkaido, Japan.

Liver stiffness (LS) has been reported to be a marker of liver congestion caused by elevated central venous pressure in heart failure (HF) patients. Recent studies demonstrated that LS could be non-invasively measured by virtual touch quantification (VTQ). However, its prognostic implication in patients with acute decompensated heart failure (ADHF) is unclear. Read More

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December 2018

[A Diagnostic Imaging Approach for Tremor].

Brain Nerve 2018 Dec;70(12):1331-1340

Diagnostic and Interventional Radiology, Hokkaido university hospital.

Tremor is one of the common movement disorders encountered in a clinical practice. Tremor is often difficult to diagnose and can be easily mistaken for another disorder, hence diagnostic imaging is employed to provide objective information. The morphometry, signal changes, neuromelanin, and iron deposition can be evaluated by MRI, whereas cardiac sympathetic nerve and dopamine transporter degeneration are detected by means of nuclear medicine. Read More

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December 2018

HLA discrepancy between graft and host rather than that graft and first donor impact the second transplant outcome.

Haematologica 2018 Dec 6. Epub 2018 Dec 6.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Second allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment option for patients with hematologic malignancies. However, it is unclear whether HLA discrepancy between graft and first donor has an impact on the outcome of second HSCT. We retrospectively analyzed 646 patients receiving second HSCT after an initial HLA mismatched (MM) transplantation. Read More

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December 2018

Pioglitazone improves visceral sensation and colonic permeability in a rat model of irritable bowel syndrome.

J Pharmacol Sci 2018 Nov 24. Epub 2018 Nov 24.

Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan; Department of General Medicine, Asahikawa Medical University, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.

Visceral hypersensitivity and impaired gut barrier with minor inflammation are considered to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Since pioglitazone is known to have anti-inflammatory property, we hypothesized that pioglitazone is beneficial for treating IBS. In this study, the effect was tested in rat IBS models such as lipopolysaccharide or repeated water avoidance stress-induced visceral allodynia and increased colonic permeability. Read More

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November 2018

Sonodynamic Therapy for Malignant Glioma Using 220-kHz Transcranial Magnetic Resonance Imaging-Guided Focused Ultrasound and 5-Aminolevulinic acid.

Ultrasound Med Biol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurosurgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Sonodynamic therapy (SDT) is used to treat various malignancies and can be applied to brain tumors using a transcranial magnetic resonance imaging-guided focused ultrasound (TcMRgFUS) device. This study investigated the efficacy of 220-kHz TcMRgFUS combined with 5-aminolevulinic acid (5-ALA) on malignant glioma in vitro and in vivo. F98 cells were irradiated with focused ultrasound (FUS) (4000 J, 20 W, 240 s, 100% duty cycle, target medium temperature <40°C) after treatment with 200 µg/mL 5-ALA, and cell viability and apoptosis were evaluated with the water-soluble tetrazolium-1 assay, triple fluorescent staining and Western blot analysis 20 h later. Read More

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December 2018

Automatic detection of fish sounds based on multi-stage classification including logistic regression via adaptive feature weighting.

J Acoust Soc Am 2018 Nov;144(5):2709

National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama, Kanagawa 236-8648, Japan.

This paper presents a method for automatic detection of fish sounds in an underwater environment. There exist two difficulties: (i) features and classifiers that provide good detection results differ depending on the underwater environment and (ii) there are cases where a large amount of training data that is necessary for supervised machine learning cannot be prepared. A method presented in this paper (the proposed hybrid method) overcomes these difficulties as follows. Read More

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November 2018

Morphological evaluation of the calcaneofibular ligament in different ankle positions using a three-dimensional MRI sequence.

Surg Radiol Anat 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedic Surgery, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, 060-8543, Japan.

Purpose: Evaluating images of the lateral ligament of the ankle is not easy, and evaluation of the calcaneofibular ligament (CFL) in particular is difficult. We prospectively conducted morphological measurements of the CFL in different ankle positions and obtain basic data for use in functional assessment of the CFL, diagnosis of CFL injury, and determination of treatment effects.

Methods: The subjects were ten healthy volunteers (ten ankles) with a mean age of 27. Read More

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December 2018

Utility of "liquid biopsy" using pancreatic juice for early detection of pancreatic cancer.

Endosc Int Open 2018 Dec 10;6(12):E1454-E1461. Epub 2018 Dec 10.

Department of Medicine, Asahikawa Medical University, Asahikawa, Hokkaido 078-8510, Japan.

 Despite advances in the diagnosis of pancreatic ductal adenocarcinoma (PDA), histological evaluation of small and poorly defined masses in the pancreas is uncomfortable and unsafe.  We herein report a case of early stage PDA, in which multiple KRAS mutations were detected in the pancreatic juice preoperatively. A small hypoechoic area adjacent to the portal vein was detected through endoscopic ultrasound in the pancreatic body. Read More

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December 2018

Unusual bilateral ureter strangulation by fibrous tissue after perineal hernia repair in a dog.

Open Vet J 2018 19;8(4):441-444. Epub 2018 Nov 19.

Hokkaido University Veterinary Teaching Hospital, Kita 19, Nishi 10, Kita-ku, Sapporo, Hokkaido 060-0819, Japan.

A 10-year-old castrated male cross-breed dog was referred for the repair of perineal hernia with bladder retroflexion and a mass lesion in the hernial sac. Surgical treatment was performed and the mass was identified as degenerated adipose tissue that was suspected to be derived from the omentum. The hernial contents were reduced without difficulty, and the dog exhibited a normal recovery. Read More

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November 2018

Expression of VEGF in human conjunctival melanoma analyzed with immunohistochemistry.

Clin Ophthalmol 2018 19;12:2363-2367. Epub 2018 Nov 19.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan,

Purpose: The aim of this study was to examine the immunolocalization of VEGF-A and CD34, a marker of endothelial cells, in human conjunctival melanoma.

Methods: This study retrospectively analyzed primary conjunctival melanoma patients who underwent surgical resection of the tumor. All excised tissues were fixed with paraformaldehyde and embedded in paraffin, which were then submitted for immunohistochemistry with anti-VEGF and CD34 antibodies. Read More

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November 2018

Isolated cardiac sarcoidosis requiring open-chest myocardial biopsy for differentiation from malignant lymphoma.

J Cardiol Cases 2014 Jun 18;9(6):239-242. Epub 2014 Apr 18.

Cardiovascular, Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical University, Hokkaido, Japan.

A 68-year-old woman with a history of hypertension was admitted to our hospital because of dyspnea during physical exertion. Echocardiography demonstrated impaired left ventricular systolic function, and her ejection fraction was reduced to 30%. Coronary angiography did not show significant stenosis. Read More

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A new paradigm for the treatment of volume overload in heart failure-combined effect of tolvaptan with furosemide.

Authors:
Hiroshi Okamoto

J Cardiol Cases 2013 Dec 30;8(6):193-194. Epub 2013 Oct 30.

Department of Cardiovascular Medicine, Hokkaido Medical Center, 5-7 Yamanote, Nishi-ku, Sapporo 063-0005, Japan.

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December 2013