1,310 results match your criteria Hodgkin Disease Thoracic


Clinical intensity-modulated proton therapy for Hodgkin lymphoma: which patients benefit the most?

Pract Radiat Oncol 2019 Jan 29. Epub 2019 Jan 29.

Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK; Oxford Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Purpose: Radiotherapy (RT) improves control of Hodgkin lymphoma (HL), but patients undergoing RT are at risk of late effects, including cardiovascular disease and second cancers, due to radiation dose to organs at risk (OAR). Proton therapy (PT) can reduce OAR dose compared to conventional photon RT. However, access to PT is currently limited so referral must be appropriately selective. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18798500193000
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http://dx.doi.org/10.1016/j.prro.2019.01.006DOI Listing
January 2019
2 Reads

PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study.

Lancet Oncol 2019 Feb 15;20(2):202-215. Epub 2019 Jan 15.

LYSA Imaging, Hôpital H Mondor, Creteil, France.

Background: Increased-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) improves progression-free survival in patients with advanced Hodgkin lymphoma compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), but is associated with increased risks of haematological toxicity, secondary myelodysplasia or leukaemia, and infertility. We investigated whether PET monitoring during treatment could allow dose de-escalation by switching regimen (BEACOPP to ABVD) in early responders without loss of disease control compared with standard treatment without PET monitoring.

Methods: AHL2011 is a randomised, non-inferiority, phase 3 study done in 90 centres across Belgium and France. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30784-8DOI Listing
February 2019
3 Reads
24.690 Impact Factor

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
5 Reads

Reconstruction of anterior chest wall: a clinical analysis.

J Cardiothorac Surg 2018 Dec 7;13(1):124. Epub 2018 Dec 7.

Department of thoracic surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Objective: To investigate the methods and clinical efficacy of reconstruction of chest defects with titanium sternal fixation system after the surgical resection of sternal tumors.

Methods: A total of 6 patients with sternal tumor who were diagnosed and underwent resection and repair of the chest wall defects by titanium plates system, from 2017.3 to 2017. Read More

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https://cardiothoracicsurgery.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13019-018-0810-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286520PMC
December 2018
9 Reads
1.018 Impact Factor

Expression of the immune checkpoint receptor TIGIT in Hodgkin's lymphoma.

BMC Cancer 2018 Dec 4;18(1):1209. Epub 2018 Dec 4.

Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Hodgkin's lymphoma (HL) is characterized by a high background of inflammatory cells which play an important role for the pathogenesis of the disease. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor and a putative target for novel immunotherapies. To study patterns of TIGIT expression in the T cell background surrounding malignant cells including Hodgkin cells, Reed-Sternberg cells and histiocytic cells, a microenvironment (ME) tissue microarray (TMA) was constructed from tissue punches measuring 2 mm in diameter obtained from formalin-fixed tissue samples of Hodgkin's lymphoma lymph nodes (n = 40) and normal human tonsil (n = 2). Read More

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http://dx.doi.org/10.1186/s12885-018-5111-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280445PMC
December 2018
12 Reads

A role for surgery in the treatment of relapsed Hodgkin lymphoma.

Pediatr Blood Cancer 2019 Jan 8;66(1):e27402. Epub 2018 Oct 8.

Division of General and Thoracic Surgery, Hospital for Sick Children/University of Toronto, Toronto, Canada.

Treatment of Hodgkin lymphoma (HL) has advanced over time, rendering a fatal disease now largely curable. Multiagent chemotherapy regimens, hematopoietic stem cell transplantation, and radiotherapy are the mainstays of care. Surgical intervention is rarely indicated other than for biopsy at diagnosis. Read More

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http://doi.wiley.com/10.1002/pbc.27402
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http://dx.doi.org/10.1002/pbc.27402DOI Listing
January 2019
9 Reads

Significance of pleural effusion at diagnosis in pediatric Hodgkin lymphoma: a report from Children's Oncology Group protocol AHOD0031.

Pediatr Radiol 2018 11 16;48(12):1736-1744. Epub 2018 Jul 16.

Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, NY, USA.

Background: Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated.

Objective: To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors.

Materials And Methods: Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review. Read More

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http://dx.doi.org/10.1007/s00247-018-4197-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208959PMC
November 2018
14 Reads

A Mediastinal Mass in a Young Man.

JAMA 2018 06;319(23):2432-2433

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.7107DOI Listing
June 2018
4 Reads

Anterior mediastinal Hodgkin lymphoma presenting as an extremely hypervascular tumor on computed tomography: A case report.

Medicine (Baltimore) 2018 May;97(19):e0607

Department of Thoracic Surgery, CHA Bundang Medical Center, CHA University, Bundang-gu, Seongnam-si, Republic of Korea.

Rationale: In the thorax, Hodgkin lymphoma (HL) most frequently involves the anterior mediastinal and paratracheal regions and tends to spread to contiguous nodal groups. Enlarged lymph nodes typically have homogeneous soft tissue attenuation similar to that of muscle tissue on computed tomography (CT).

Patient Concerns: A contrast-enhanced CT examination of a 19-year-old man with right-sided chest pain showed an intense, heterogeneously enhancing mass with organization of serpentine and dilated blood vessels in the right anterior mediastinum that had invaded the upper lobe of the right lung. Read More

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http://Insights.ovid.com/crossref?an=00005792-201805110-0001
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http://dx.doi.org/10.1097/MD.0000000000010607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959439PMC
May 2018
6 Reads

Primary Spinal Lymphoma Masquerading as Meningioma: Preoperative and Postoperative Magnetic Resonance Imaging Findings.

World Neurosurg 2018 Oct 26;118:86-87. Epub 2018 Apr 26.

Department of Neurosurgery, Van Yuzuncu Yıl University, Dursun Odabası Faculty of Medicine, Van, Turkey.

A 55-year-old male who complained of frequent back pain accompanied by increasing weakness in the lower extremities was admitted to our hospital's Neurosurgery Department. No additional disease was in his history. Magnetic resonance imaging of the thoracic area, anterior epidural space, and paravertebral area revealed an approximately 55 × 9 mm lymphoma pressuring the spinal cord from the anterior. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.129DOI Listing
October 2018
2 Reads

Lactate dehydrogenase levels and 18F-FDG PET/CT metrics differentiate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma.

Nucl Med Commun 2018 Jun;39(6):572-578

Departments of Radiology, Nuclear Medicine and Molecular Imaging, Medical Imaging Center.

Purpose: This study aims to investigate whether clinical, laboratory, and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT findings can discriminate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma (PMBCL).

Patients And Methods: This retrospective study included 56 patients (42 with mediastinal Hodgkin's lymphoma and 14 with PBMCL). Differences in clinical, laboratory, and F-FDG PET/CT metrics were assessed between Hodgkin's lymphoma and PMBCL. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000840DOI Listing
June 2018
9 Reads

Synchronous Pulmonary Neoplasms: A Chance Occurrence or is There More Than Meets the Eye?

Cureus 2018 Feb 6;10(2):e2162. Epub 2018 Feb 6.

Department of Hematology and Oncology, Staten Island University Hospital.

Primary bronchus-associated lymphoid tissue (BALT) lymphoma comprises 5% of non-Hodgkin's lymphoma (NHL) and usually has an indolent course. Synchronous primary lung cancers with BALT lymphoma are seldom seen in patients with adenocarcinoma of the lung. Synchronous squamous cell carcinoma (SCC) and BALT lymphoma is an extremely rare occurrence. Read More

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http://dx.doi.org/10.7759/cureus.2162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893181PMC
February 2018
3 Reads

Rare case of radiation-induced primary tracheal carcinoma.

Gen Thorac Cardiovasc Surg 2018 Sep 15;66(9):549-551. Epub 2018 Mar 15.

Section of Thoracic Surgery, Yale University School of Medicine, BB205, 330 Cedar Street, New Haven, CT, 06520, USA.

Primary carcinoma of the trachea is an exceeding rare entity. We present a case of radiation-induced primary squamous cell carcinoma of the trachea in a young woman. The case highlights a diagnostic challenge of this atypical disease entity. Read More

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http://dx.doi.org/10.1007/s11748-018-0907-0DOI Listing
September 2018
3 Reads

Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study.

BMC Cancer 2018 03 12;18(1):281. Epub 2018 Mar 12.

The First Affiliated Hospital of Wenzhou Medical University & Key Laboratory of Heart and Lung, Zhejiang, 325035, China.

Background: The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and summarizes misdiagnosis reasons of PPL cases, aims to provide a better understanding and increase the accuracy of early diagnosis and minimize the misdiagnosis of PPL.

Methods: The clinical data of 19 cases were collected from the first affiliated hospital of Wenzhou medical university (PRC) from April 2010 to May 2016. Read More

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http://dx.doi.org/10.1186/s12885-018-4184-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848441PMC
March 2018
8 Reads

Hodgkin Lymphoma revealed by epidural spinal cord compression.

J Spinal Cord Med 2018 Jan 30:1-4. Epub 2018 Jan 30.

a Neurosurgery Department , Institut National de Neurologie, Faculté de Médecine de Tunis , Tunisia.

Context: Hodgkin Lymphoma is rarely diagnosed as spinal cord compression syndrome. Caused by an epidural mass, this complication is often encountered in a late stage of the disease. We report the case of a 40-year-old man presenting with symptoms of low thoracic spinal cord compression due to an epidural tumor on the MRI. Read More

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http://dx.doi.org/10.1080/10790268.2018.1427519DOI Listing
January 2018
5 Reads

A Patient with Non-Hodgkin Lymphoma and Nonspecific Interstitial Pneumonia during Ibrutinib Therapy.

Case Rep Oncol Med 2017 10;2017:5640186. Epub 2017 Nov 10.

Department of Pneumology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Berlin, Germany.

We present a 74-year-old male with nonspecific interstitial pneumonia (NSIP) during treatment with ibrutinib for mantle cell lymphoma. Previously, the patient had received six cycles of bendamustine and rituximab and six cycles of R-CHOP, followed by rituximab maintenance therapy. Respiratory tract complications of ibrutinib other than infectious pneumonia have not been mentioned in larger trials, but individual case reports hinted to a possible association with the development of pneumonitis. Read More

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http://dx.doi.org/10.1155/2017/5640186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702410PMC
November 2017
22 Reads

Comparison of 36 Gy, 20 Gy, or No Radiation Therapy After 6 Cycles of EBVP Chemotherapy and Complete Remission in Early-Stage Hodgkin Lymphoma Without Risk Factors: Results of the EORT-GELA H9-F Intergroup Randomized Trial.

Int J Radiat Oncol Biol Phys 2018 Apr 27;100(5):1133-1145. Epub 2017 Oct 27.

Centre de Traitement des Données du Cancéropôle Nord-Ouest, Centre François Baclesse, Caen, France. Electronic address:

Purpose: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy.

Methods And Materials: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2017.10.015DOI Listing
April 2018
38 Reads

Different manifestation of irradiation induced coronary artery disease detected with coronary computed tomography compared with matched non-irradiated controls.

Radiother Oncol 2017 10 4;125(1):55-61. Epub 2017 Oct 4.

Department of Cardiology, Leiden University Medical Center, The Netherlands. Electronic address:

Background And Purpose: Patients who received chest irradiation for treatment of a malignancy are at increased risk for the development of coronary artery atherosclerosis. Little is known about the anatomical coronary artery plaque characteristics of irradiation induced coronary artery disease (CAD). This study aimed to evaluate potential differences in the presence, extent, severity, composition and location of CAD in patients treated with mediastinal irradiation compared with non-irradiated controls matched on age, gender and cardiovascular risk factors. Read More

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http://dx.doi.org/10.1016/j.radonc.2017.09.008DOI Listing
October 2017
13 Reads

Pulmonary Toxicity Following Proton Therapy for Thoracic Lymphoma.

Int J Radiat Oncol Biol Phys 2017 10 11;99(2):494-497. Epub 2017 Apr 11.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.04.001DOI Listing
October 2017
7 Reads

The risk of reoperative cardiac surgery in radiation-induced valvular disease.

J Thorac Cardiovasc Surg 2017 Dec 29;154(6):1883-1895. Epub 2017 Jul 29.

Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

Objective: Mediastinal radiation therapy (MRT) increases the risk for adverse outcomes after cardiac surgery and is not incorporated in the Society of Thoracic Surgeons (STS) risk algorithm. We aimed to quantify the surgical risk conferred by MRT in patients undergoing primary and reoperative valvular operations.

Methods: A retrospective analysis of 261 consecutive patients with prior MRT who underwent valvular operations between January 2002 and May 2015. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2017.07.033DOI Listing
December 2017
12 Reads

[Doses to organs at risk in conformational radiotherapy and stereotaxic irradiation: The heart].

Cancer Radiother 2017 Oct 1;21(6-7):626-635. Epub 2017 Sep 1.

Département d'oncologie radiothérapie, institut Curie, 26, rue d'Ulm, 75005 Paris, France.

Radiation therapy of breast cancer, Hodgkin lymphoma, lung cancer and others thoracic irradiations induce an ionizing radiation dose to the heart. Irradiation of the heart, associated with patient cardiovascular risk and cancer treatment-induced cardiotoxicity, increase cardiovascular mortality. The long survival after breast or Hodgkin lymphoma irradiation requires watching carefully late treatment toxicity. Read More

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http://dx.doi.org/10.1016/j.canrad.2017.07.044DOI Listing
October 2017
4 Reads

[A case of severe left main isolated stenosis in a young woman with previous history of non-Hodgkin lymphoma].

G Ital Cardiol (Rome) 2017 Sep;18(9):668-671

U.O.C. Cardiologia, Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliero-Universitaria di Parma.

We report the case of a 34-year-old female treated with radiotherapy and chemotherapy for non-Hodgkin lymphoma at the age of 16. The patient came to our attention because of progressive dyspnea on effort and a positive result on a pharmacologic stress echo test. Coronary angiography revealed focal critical ostial stenosis of the left main coronary artery. Read More

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http://dx.doi.org/10.1714/2741.27951DOI Listing
September 2017
3 Reads

Chest wall lymphomas: Fine needle aspiration cytodiagnosis and review of the literature.

Cytopathology 2017 Oct 21;28(5):364-370. Epub 2017 Jul 21.

Cytology Unit, Mubarak Al-Kabeer Hospital, Al-Jabriya, Kuwait.

Objective: Compared to other chest wall malignancies, lymphoma is a common disease. However, published literature on a series of lymphoma cases involving the chest wall is scarce. The aim of the present study, was to describe experience with chest wall swellings diagnosed as lymphoid neoplasms on fine needle aspiration (FNA) cytology. Read More

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http://dx.doi.org/10.1111/cyt.12433DOI Listing
October 2017
5 Reads

Late Cardiac Toxicity After Mediastinal Radiation Therapy for Hodgkin Lymphoma: Contributions of Coronary Artery and Whole Heart Dose-Volume Variables to Risk Prediction.

Int J Radiat Oncol Biol Phys 2017 08 27;98(5):1116-1123. Epub 2017 Mar 27.

Radiation Medicine Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; Pediatric Oncology Group of Ontario, Toronto, Ontario, Canada. Electronic address:

Purpose: Mediastinal radiation therapy (RT) for Hodgkin lymphoma (HL) is associated with late cardiotoxicity, but there are limited data to indicate which dosimetric parameters are most valuable for predicting this risk. This study investigated which whole heart dosimetric measurements provide the most information regarding late cardiotoxicity, and whether coronary artery dosimetry was more predictive of this outcome than whole heart dosimetry.

Methods And Materials: A random sample of 125 HL patients treated with mediastinal RT was selected, and 3-dimensional cardiac dose-volume data were generated from historical plans using validated methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016173071
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http://dx.doi.org/10.1016/j.ijrobp.2017.03.026DOI Listing
August 2017
5 Reads

Dual-Energy CT: New Horizon in Medical Imaging.

Korean J Radiol 2017 Jul-Aug;18(4):555-569. Epub 2017 May 19.

Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Korea.

Dual-energy CT has remained underutilized over the past decade probably due to a cumbersome workflow issue and current technical limitations. Clinical radiologists should be made aware of the potential clinical benefits of dual-energy CT over single-energy CT. To accomplish this aim, the basic principle, current acquisition methods with advantages and disadvantages, and various material-specific imaging methods as clinical applications of dual-energy CT should be addressed in detail. Read More

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http://dx.doi.org/10.3348/kjr.2017.18.4.555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447632PMC
October 2017
7 Reads

ABVD or BEACOPP along with involved-field radiotherapy in early-stage Hodgkin Lymphoma with risk factors: Results of the European Organisation for Research and Treatment of Cancer (EORTC)-Groupe d'Étude des Lymphomes de l'Adulte (GELA) H9-U intergroup randomised trial.

Eur J Cancer 2017 08 8;81:45-55. Epub 2017 Jun 8.

Centre de Traitement des Données du Cancéropôle Nord-Ouest, Centre François Baclesse, 3 Avenue Général Harris, 14076 Caen Cedex 05, France. Electronic address:

Purpose: For early-stage Hodgkin lymphoma (HL), optimal chemotherapy regimen and the number of cycles to be delivered remain to settle down. The H9-U trial compared three modalities of chemotherapy followed by involved-field radiotherapy (IFRT) in patients with stage I-II HL and risk factors (NCT00005584).

Patients And Methods: Patients aged 15-70 years with untreated supradiaphragmatic HL with at least one risk factor (age ≥ 50, involvement of 4-5 nodal areas, mediastinum/thoracic ratio ≥ 0. Read More

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http://dx.doi.org/10.1016/j.ejca.2017.05.005DOI Listing
August 2017
60 Reads

Comparison of pediatric and adult lymphomas involving the mediastinum characterized by distinctive clinicopathological and radiological features.

Sci Rep 2017 05 31;7(1):2577. Epub 2017 May 31.

Department of Pediatric Hematology/Oncology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Lymphomas involving the mediastinum occur in a wide age range and represent heterogeneous histological subtypes with various clinical symptoms and complex radiological findings. However, studies that describe the clinical and radiological features of different subtypes among Chinese pediatric and adult patients are limited. We analyzed the clinical, radiological and pathological features of 31 pediatric lymphomas involving the mediastinum, and compared them to the features of 21 adult patients. Read More

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http://dx.doi.org/10.1038/s41598-017-02720-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451435PMC
May 2017
13 Reads

FDG PET/CT Findings of Nodular Sclerosis-Subtype Classic Hodgkin Lymphoma Presented as Mediastinal Nodal Lesions at Onset But as Predominant Osseous Disease at Relapse.

Clin Nucl Med 2017 Jun;42(6):496-498

From the *Department of Nuclear Medicine, Peking Union Hospital, Beijing, China; and †Department of Radiology, The Children's Hospital of Philadelphia, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA.

Nodular sclerosis-subtype classic Hodgkin lymphoma in general manifests as bulky mediastinal lymphadenopathy but very rarely involves bones. We report FDG PET/CT findings of a 19-year-old man with pathology-proven, nodular sclerosis-type classic Hodgkin lymphoma. His initial FDG PET/CT scan at the diagnosis showed only hypermetabolic lymphadenopathy in the mediastinum. Read More

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http://Insights.ovid.com/crossref?an=00003072-201706000-0002
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http://dx.doi.org/10.1097/RLU.0000000000001664DOI Listing
June 2017
4 Reads

Reconstruction of a Long-Segment Tracheal Defect Using an AlloDerm Conduit.

Innovations (Phila) 2017 Mar/Apr;12(2):137-139

From the Division of Thoracic Surgery, Department of Surgery, Greenville Health System, Greenville, SC USA.

This case describes successful reconstruction of a long-segment tracheal defect using AlloDerm as the conduit for reconstruction. A 38-year-old woman who had undergone a thyroid lobectomy in 2011 presented several months later unable to swallow. Chest computed tomography results revealed a tracheal/esophageal mass and a subsequent bronchoscopy, and esophagogastroduodenoscopy results revealed an upper esophageal/tracheal mass with two areas concerning for fistula. Read More

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http://dx.doi.org/10.1097/IMI.0000000000000347DOI Listing
September 2017
10 Reads

The Correlation Between Pre-treatment Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Parameters and Clinical Prognostic Factors in Pediatric Hodgkin Lymphoma.

Mol Imaging Radionucl Ther 2017 Feb;26(1):9-16

Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Nuclear Medicine, Ankara, Turkey Phone: +90 505 914 53 61 E-mail:

Objective: To compare standardized uptake values (SUV) derived from pre-treatment F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging and clinical prognostic factors in pediatric patients with Hodgkin lymphoma (HL).

Methods: Pre-treatment FDG PET/CT findings of 28 children with HL were evaluated in this retrospective study. Metabolic tumor volume (MTV), SUV normalized by weight (SUV), lean body mass (SUV), body surface area (SUV) and plasma glucose levels of tumors (SUV) were calculated using pre-treatment FDG PET/CT scan images. Read More

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http://dx.doi.org/10.4274/mirt.94914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350506PMC
February 2017
14 Reads

Spectrum of CT Findings in Thoracic Extranodal Non-Hodgkin Lymphoma.

Radiographics 2017 Mar-Apr;37(2):439-461

From the Department of Diagnostic Radiology (M.P.B., J.N.B., S.C.B., D.M.) and Division of Hematology, Department of Medicine (D.A.M.), Dalhousie University, Room 307, Victoria Building, 1276 S Park St, Halifax, NS, Canada B3H 2Y9.

Non-Hodgkin lymphoma (NHL) frequently manifests in extranodal structures in the chest, often in the form of secondary involvement but occasionally as primary disease. Because staging and treatment are affected by the presence of extranodal disease at imaging, radiologists' interpretation and management of suspicious findings are critical to patient care. Unfortunately, owing to considerable imaging overlap with other diseases, primary extranodal lymphoma is difficult to diagnose with imaging alone. Read More

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http://dx.doi.org/10.1148/rg.2017160077DOI Listing
October 2017
25 Reads

Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma. The Hellenic experience.

Hematol Oncol 2018 Feb 20;36(1):174-181. Epub 2017 Feb 20.

2nd Department of Internal Medicine, Faculty of Medicine, ATTIKON General University Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

This retrospective study aimed to describe the Hellenic experience on the use of brentuximab vedotin (BV) in relapsed/refractory (R/R) Hodgkin lymphoma (HL) given within its indication. From June 2011 to April 2015, ninety-five patients with R/R HL, who received BV in 20 centers from Greece, were analyzed. Their median age was 33 years, and 62% were males. Read More

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http://dx.doi.org/10.1002/hon.2383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836920PMC
February 2018
32 Reads
2 Citations
3.084 Impact Factor

GLUT1 as a Prognostic Factor for Classical Hodgkin's Lymphoma: Correlation with PD-L1 and PD-L2 Expression.

J Pathol Transl Med 2017 Mar 21;51(2):152-158. Epub 2017 Feb 21.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Glucose transporter type 1 (GLUT1) expression is linked to glucose metabolism and tissue hypoxia. A recent study reported that GLUT1 was significantly associated with programmed death ligand 1 (PD-L1) as a therapeutic target in relapsed or refractory classical Hodgkin's lymphoma (cHL). The purpose of this study was to measure the expression of GLUT1 and assess its prognostic significance and potential relationships with PD-L1, programmed death ligand 2 (PD-L2), and programmed death-1 (PD-1) expressions in cHL. Read More

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http://dx.doi.org/10.4132/jptm.2016.11.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357756PMC
March 2017
5 Reads

An Unusual Cause of Pulmonary Nodules After Stem Cell Transplantation.

Chest 2017 Feb;151(2):e29-e34

Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA. Electronic address:

A man in his 20s with a history of classical Hodgkin's lymphoma was admitted with fever. His original lymphoma diagnosis was made 3 years prior, when he had presented with lymphadenopathy and a mediastinal mass. He had relapsed disease despite chemotherapy and radiation. Read More

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http://dx.doi.org/10.1016/j.chest.2016.11.022DOI Listing
February 2017
5 Reads

[Thoracic Endovascular Aortic Repair for a Descending Thoracic Aneurysm Associated with Pseudocoarctation of the Aorta;Report of a Case].

Kyobu Geka 2017 Feb;70(2):123-126

Department of Cardiovascular Surgery, Hiraka General Hospital, Yokote, Japan.

A 77-year-old man with a descending thoracic aneurysm associated with pseudocoarctation of the aorta underwent thoracic endovascular aortic repair (TEVAR). Computed tomography demonstrated kinking of the descending thoracic aorta. The aneurysm was located distal to a kinking and constricting aortic isthmus. Read More

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February 2017
5 Reads

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report.

J Cardiothorac Surg 2017 Jan 25;12(1). Epub 2017 Jan 25.

Division of Chest Surgery, Toho University School of Medicine, Tokyo, Japan.

Background: Primary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B cell lymphoma that is a type of non-Hodgkin lymphoma and a type of primary pulmonary malignant lymphoma. MALT lymphomas affecting the lung show various findings on chest computed tomography, which range from typical nodules or areas of consolidation to findings that are extremely rare in pulmonary MALT lymphomas, such as pure ground-glass opacities throughout the lung.

Case Presentation: A 35-year-old woman was found to have a few shadows with ground glass opacities on chest computed tomography (CT) in 2012. Read More

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http://dx.doi.org/10.1186/s13019-017-0565-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264446PMC
January 2017
19 Reads

Prognostic significance of Epstein-Barr virus (EBV) infection in Hodgkin lymphoma patients.

J Infect Chemother 2017 Mar 26;23(3):121-130. Epub 2016 Dec 26.

Department of Pathology, University Hospital Farhat-Hached, Sousse 4000, Tunisia. Electronic address:

Introduction: The prognostic significance of Epstein-Barr virus (EBV) infection in Hodgkin lymphoma (HL) is still controversial. In this work we sought to examine the prognostic differences between EBV-positive and -negative HL through a series of 131 cases from Tunisia.

Methods: The status of EBV was assessed by EBV-encoded RNA (EBER) in situ hybridization. Read More

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http://dx.doi.org/10.1016/j.jiac.2016.09.004DOI Listing
March 2017
3 Reads

Long-term morbidity after staging laparotomy for Hodgkin lymphoma.

J Pediatr Surg 2017 Sep 2;52(9):1430-1432. Epub 2016 Dec 2.

Division of Pediatric and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. Electronic address:

Background: A large cohort of Hodgkin lymphoma (HL) survivors exist. With patients transitioning from pediatric to adult care, practitioners should be aware of potential complications. The aim of this study was to describe the long-term complications of patients who had staging laparotomy for the treatment of HL. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468163059
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http://dx.doi.org/10.1016/j.jpedsurg.2016.11.047DOI Listing
September 2017
7 Reads

Constitutional symptoms in a young person.

BMJ 2016 Dec 7;355:i5781. Epub 2016 Dec 7.

East Sussex Healthcare Trust, Eastbourne District General Hospital, King's Drive, Eastbourne, UK.

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http://dx.doi.org/10.1136/bmj.i5781DOI Listing
December 2016
3 Reads

Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth.

Oncotarget 2017 01;8(1):552-564

Department of Surgery, Medical University of Vienna, General Hospital, Vienna, Austria.

The oncogenic potential of the transcriptional repressor Bcl-6 (B-cell lymphoma 6) was originally discovered in non-Hodgkin patients and the soluble Bcl-6 inhibitor 79-6 was developed to treat diffuse large B-cell lymphomas with aberrant Bcl-6 expression. Since we found Bcl-6 and its co-repressor BCoR (Bcl-6 interacting co-repressor) to be regulated in human microvascular endothelium by colorectal cancer cells, we investigated their function in sprouting angiogenesis which is central to tumor growth. Based on Bcl-6/BCoR gene silencing we found that the transcriptional repressor complex in fact constitutes an endogenous inhibitor of vascular sprouting by supporting the stalk cell phenotype: control of Notch target genes (HES1, HEY1, DLL4) and cell cycle regulators (cyclin A and B1). Read More

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http://dx.doi.org/10.18632/oncotarget.13477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352177PMC
January 2017
34 Reads

Open vascular plug placement to complete mitral valve seating in radiation heart disease.

J Thorac Cardiovasc Surg 2016 11 30;152(5):e101-e102. Epub 2016 Jul 30.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2016.06.061DOI Listing
November 2016
1 Read

Spectrum of Radiological Manifestations in Lymphoproliferative Malignancies with Unusual Extra Nodal Soft Tissue Involvement.

J Clin Diagn Res 2016 Jul 1;10(7):TR01-5. Epub 2016 Jul 1.

Head of the Department of Radiology, Dr. Ram Manohar Lohia Hospital and Postgraduate Institute of Medical Education and Research , New Delhi, India .

Lymphoproliferative malignancies constitute a wide spectrum of haematological malignancies and their prevalence is widely increasing. Non-Hodgkin lymphomas and Hodgkin disease, frequently involve extranodal soft tissue structures in the head and neck, thorax and abdomen. These malignancies may involve virtually any type of soft tissues to any extent; hence many different imaging manifestations are possible which may mimic other disorders. Read More

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http://dx.doi.org/10.7860/JCDR/2016/17729.8076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020295PMC
July 2016
9 Reads

DIFFUSE LARGE B-CELL LYMPHOMA-ASSOCIATED-RETINOPATHY CHARACTERIZED BY MINIMAL MORPHOLOGIC CHANGES AND SEVERE FUNCTIONAL IMPAIRMENT.

Retin Cases Brief Rep 2017 Winter;11 Suppl 1:S2-S6

*Department of Ophthalmology, Intercommunal hospital of Creteil, Creteil, France; †Department of Ocular Immunology, University of California, Davis, California; ‡Lymphoid Malignancies Unit, Henri Mondor Hospital, Creteil, France; and §Hematology Department, University Paris Est, Creteil, France.

Purpose: To report the case of a patient whose retinal disease was found to be associated with a diffuse large B-cell lymphoma found 30 years after the apparent successful treatment of a classical Hodgkin lymphoma.

Methods: Observational case report.

Results: The authors describe the case of a 69-year-old man referred to their Department because of progressive, bilateral vision loss over the last few months. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000379DOI Listing
April 2017
14 Reads

The American College of Radiology Lung Imaging Reporting and Data System: Potential Drawbacks and Need for Revision.

Chest 2017 03 10;151(3):539-543. Epub 2016 Aug 10.

Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, College of Medicine, Gainesville, FL.

Lung cancer screening using low-dose CT scanning reduces lung-cancer-specific and overall mortality in high-risk patients. A significant limitation of lung cancer screening is the false-positive rate. The American College of Radiology Lung Imaging Reporting and Data System (Lung-RADS) was designed to standardize reporting of low-dose lung cancer screening results and to decrease the false-positive rate without significantly compromising sensitivity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692165366
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http://dx.doi.org/10.1016/j.chest.2016.07.028DOI Listing
March 2017
10 Reads

[Mediastinal lymphomas].

Pathologe 2016 Sep;37(5):457-64

Institut für Pathologie, Universität Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Deutschland.

Lymphomas infiltrating the mediastinum are a challenge for the treating physician as well as for the pathological diagnostics. The clinical scenario is often an emergency situation, while the pathologist is usually confronted only with small biopsy samples. Classical Hodgkin's lymphoma is by far the most frequently occurring lymphoma in the mediastinum and predominantly the nodular sclerosis subtype. Read More

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http://dx.doi.org/10.1007/s00292-016-0199-zDOI Listing
September 2016
4 Reads

Guillain-Barré Syndrome as First Presentation of Non-Hodgkin's Lymphoma.

Acta Med Iran 2016 Jul;54(7):471-4

Department of Neurosurgery, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Brain and Spinal Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We present a woman referred with underlying non-Hodgkin's lymphoma (NHL) masquerading clinically with Guillain-Barré syndrome (GBS) like syndrome. At first evaluation, chest CT-Scan along with brain and whole spine MRI were normal. Electrodiagnostic studies were in favor of acute generalized polyradiculoneuropathy. Read More

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July 2016
14 Reads

18F-FDG PET/CT Imaging of Hodgkin Lymphoma in a Child with Common Variable Immunodeficiency.

J Nucl Med Technol 2016 Dec 30;44(4):259-260. Epub 2016 Jun 30.

Department of Nuclear Medicine, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey.

Common variable immunodeficiency is characterized by low levels of serum immunoglobulins and antibodies, recurrent infections, and a predisposition to malignancy. Here, we present the F-FDG PET/CT findings of a 7-y-old boy with common variable immunodeficiency and Hodgkin lymphoma. Read More

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http://dx.doi.org/10.2967/jnmt.116.175745DOI Listing
December 2016
5 Reads

A case of Langerhans' cell histiocytosis following Hodgkin's disease.

Mol Clin Oncol 2016 Jul 19;5(1):27-30. Epub 2016 Apr 19.

Department of Hematology, The First Central Hospital of Tianjin, Tianjin 300192, P.R. China.

Langerhans' cell histiocytosis (LCH) is a group of disorders in various tissues characterized by the proliferation of Langerhans cells. It is rarely observed in adults. Langerhans cells are dendritic cells that express cluster of differentiation 1a (CD1a) and S100 protein, and contain Birbeck granules. Read More

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http://dx.doi.org/10.3892/mco.2016.860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906978PMC
July 2016
7 Reads

Hybrid FDG-PET/MR compared to FDG-PET/CT in adult lymphoma patients.

Abdom Radiol (NY) 2016 07;41(7):1338-48

Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, 02129, USA.

Purpose: The goal of this study is to evaluate the diagnostic performance of simultaneous FDG-PET/MR including diffusion compared to FDG-PET/CT in patients with lymphoma.

Methods: Eighteen patients with a confirmed diagnosis of non-Hodgkin's (NHL) or Hodgkin's lymphoma (HL) underwent an IRB-approved, single-injection/dual-imaging protocol consisting of a clinical FDG-PET/CT and subsequent FDG-PET/MR scan. PET images from both modalities were reconstructed iteratively. Read More

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http://dx.doi.org/10.1007/s00261-016-0638-6DOI Listing
July 2016
8 Reads

Persistence of dysphagia and odynophagia after mediastinal radiation and chemotherapy in patients with lung cancer or lymphoma.

Dis Esophagus 2017 02;30(2):1-8

Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Esophageal symptoms are common during radiation and chemotherapy. It is unclear how often these symptoms persist after therapy. We retrospectively reviewed medical records of 320 adults treated for nonmetastatic breast cancer (84), lung cancer (109), or Hodgkin and non-Hodgkin lymphoma (127) who were disease-free at 10-14 months after therapy. Read More

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http://dx.doi.org/10.1111/dote.12498DOI Listing
February 2017
12 Reads