1,334 results match your criteria Hodgkin Disease Thoracic


Valvular Damage.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S26-S32. Epub 2020 Apr 10.

Department of Heart, University Hospital of Salerno, Salerno, Italy.

Valvular heart diseases (VHD) may be observed in patients with cancer for several reasons, including preexisting valve lesions, radiotherapy, infective endocarditis, and secondary to the left ventricle dysfunction. The incidence of VHD is especially in younger survivors treated with thoracic radiation therapy for certain malignancies, such as Hodgkin's lymphoma and breast cancer. The mechanism of radiation-induced damage to heart valves is not clear and includes diffuse fibrocalcific thickening of the valve. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_5_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293871PMC

Burkitt's lymphoma of the prostate presenting as acute urinary retention: a case report.

BMC Urol 2020 May 6;20(1):53. Epub 2020 May 6.

Department of Urology and Pediatric Urology, University Hospital, Philipps-University Marburg, Baldingerstr. 1, 35043, Marburg, Germany.

Background: Non-Hodgkin lymphomas, which include Burkitt's lymphoma, affect the prostate in only 0.1% of cases. They most commonly present as painless lymphadenopathy elsewhere in the body and can cause abdominal or thoracic pain and systemic symptoms such as fever, weight loss and night sweats. Read More

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http://dx.doi.org/10.1186/s12894-020-00616-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203870PMC

Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers.

BMC Cancer 2020 Jan 28;20(1). Epub 2020 Jan 28.

Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Background: The presence of comorbidity affects the care of cancer patients, many of whom are living with multiple comorbidities. The prevalence of cancer comorbidity, beyond summary metrics, is not well known. This study aims to estimate the prevalence of comorbid conditions among cancer patients in England, and describe the association between cancer comorbidity and socio-economic position, using population-based electronic health records. Read More

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http://dx.doi.org/10.1186/s12885-019-6472-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986047PMC
January 2020

Hodgkin lymphoma presenting as alcohol-induced back pain.

BMJ Case Rep 2019 Nov 28;12(11). Epub 2019 Nov 28.

Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

A 32-year-old Chinese man without significant medical history presented with a 2-month history of worsening lumbosacral back pain radiating to the groin and left lower extremity. He also described a shooting pain in the sciatic nerve distribution that began with and was exacerbated by alcohol consumption, a rare but known symptom of Hodgkin lymphoma (HL). On exam, an anterior chest wall mass was noted. Read More

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http://dx.doi.org/10.1136/bcr-2018-228440DOI Listing
November 2019

Post Radiation Grade 3 neuroendocrine carcinoma (PRNEC): a new entity?

Neuroendocrinology 2019 Oct 22. Epub 2019 Oct 22.

Background: Cancer survivors have a 14% increased risk of developing a malignancy compared with the general population. Second radiation-induced malignancies with different histologies have been described in different organs. Based on individual observations, we hypothesized that Neuroendocrine carcinoma (NEC) could arise in irradiated organs. Read More

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http://dx.doi.org/10.1159/000504255DOI Listing
October 2019
1 Read

Fit-For-Purpose PD-L1 Biomarker Testing For Patient Selection in Immuno-Oncology: Guidelines For Clinical Laboratories From the Canadian Association of Pathologists-Association Canadienne Des Pathologistes (CAP-ACP).

Appl Immunohistochem Mol Morphol 2019 Nov/Dec;27(10):699-714

Canadian Immunohistochemistry Quality Control.

Since 2014, programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) checkpoint inhibitors have been approved by various regulatory agencies for the treatment of multiple cancers including melanoma, lung cancer, urothelial carcinoma, renal cell carcinoma, head and neck cancer, classical Hodgkin lymphoma, colorectal cancer, gastroesophageal cancer, hepatocellular cancer, and other solid tumors. Of these approved drug/disease combinations, a subset also has regulatory agency-approved, commercially available companion/complementary diagnostic assays that were clinically validated using data from their corresponding clinical trials. The objective of this document is to provide evidence-based guidance to assist clinical laboratories in establishing fit-for-purpose PD-L1 biomarker assays that can accurately identify patients with specific tumor types who may respond to specific approved immuno-oncology therapies targeting the PD-1/PD-L1 checkpoint. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887625PMC
October 2019
4 Reads

Primary Mediastinal Nodal and Extranodal Non-Hodgkin Lymphomas: Current Concepts, Historical Evolution, and Useful Diagnostic Approach: Part 1.

Adv Anat Pathol 2019 Nov;26(6):346-370

Department of Pathology, M.D. Anderson Cancer Center, Houston, TX.

Primary mediastinal non-Hodgkin lymphomas (PM-NHLs) represent ~5% of all NHLs and comprise lymphomas of B-cell and T-cell origin. PM-NHLs are defined as involvement of mediastinal lymph nodes, thymus, and/or mediastinal organs (heart, lung, pleura, pericardium) by NHL without evidence of systemic disease at presentation. The clinical scenario is variable and depends on the lymphoma subtype. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000249DOI Listing
November 2019
20 Reads

Long-Term Radiotherapy-Induced Cardiac Complications: A Case Report.

Am J Case Rep 2019 Aug 11;20:1182-1188. Epub 2019 Aug 11.

Department of Cardiology, University Hospital of the Canary Islands, Tenerife, Spain.

BACKGROUND Tumor disease has improved survival due to therapeutic advances and early diagnosis. However, anti-neoplastic treatment involves generating harmful side effects in the body, both in the short-term and in the long-term. One of the most important side effects is cardiovascular disease after radiotherapy, which in addition to being influenced by classic cardiovascular risk factors, can be also be influenced by anti-neoplastic therapy, and represents the main cause of death after a second cancer. Read More

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http://dx.doi.org/10.12659/AJCR.917224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753667PMC
August 2019
3 Reads

Remission of an HHV8-related extracavitary primary effusion lymphoma in an HIV-positive patient during antiretroviral treatment containing dolutegravir.

AIDS Res Ther 2019 07 27;16(1):15. Epub 2019 Jul 27.

Clinical Infectious Disease, Department of System Medicine, Tor Vergata University, Rome, Italy.

Background: Human herpes virus 8 (HHV8) is the causative agent of Kaposi's sarcoma and has been associated with an increasing number of hematologic diseases such as primary effusion lymphoma (PEL) (both classic and extracavitary form), multicentric Castleman disease and the germinotropic lymphoproliferative disorder. PEL is a rare B cell non-Hodgkin lymphoma that primarily affects immunocompromised patients; aggressive chemotherapy and antiretroviral therapy (ART) with protease inhibitors have been used, with poor results. We present a case of extracavitary PEL in an HIV-infected patient, regressed after ART initiation. Read More

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http://dx.doi.org/10.1186/s12981-019-0230-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660660PMC
July 2019
3 Reads

The German Hodgkin Study Group risk model is useful for Hodgkin lymphoma patients receiving radiotherapy after autologous stem cell transplant.

Cancer Radiother 2019 Sep 6;23(5):378-384. Epub 2019 Jun 6.

Unit of Cell Therapy and High Dose Chemotherapy, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, 33081 Aviano, Italy.

Purpose: To apply the German Hodgkin Study Group (GHSG) risk model in patients with recurrent/refractory Hodgkin lymphoma receiving involved-field radiotherapy after autologous stem cell transplantation.

Material And Methods: The study consisted in the retrospective analysis of 30 consecutive patients with recurrent/refractory Hodgkin lymphoma who received involved-field radiotherapy after autologous stem cell transplantation. Our policy was of adding involved-field radiotherapy for patients with positive PET scan before autologous stem cell transplantation (23 out of 30 patients, 77%), and/or irradiating sites of bulky disease at relapse (11 out of 30 patients, 37%). Read More

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http://dx.doi.org/10.1016/j.canrad.2019.02.002DOI Listing
September 2019
4 Reads

OPPORTUNISTIC EVALUATION OF BONE MINERAL DENSITY BY PET-CT IN HODGKIN LYMPHOMA PATIENTS.

Endocr Pract 2019 Sep 6;25(9):869-876. Epub 2019 Jun 6.

Bone density loss and increased risk for osteoporosis are of concern in Hodgkin lymphoma (HL) patients. Routinely performed positron emission tomography-computed tomography (PET-CT) scans could be informative in assessing bone mineral density (BMD). This retrospective study included 80 adults with newly diagnosed HL treated with standard first-line chemotherapy regimens. Read More

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http://dx.doi.org/10.4158/EP-2019-0122DOI Listing
September 2019
7 Reads

Gray-zone lymphoma. Examples of rare clinical manifestation.

Ter Arkh 2019 May;91(4):107-113

National Research Center for Hematology of the Ministry of Health of the Russian Federation, Moscow, Russia.

Mediastinal gray-zone lymphoma (MGZL, lymphoma with features intermediate between classical Hodgkin lymphoma and diffuse large B-cell lymphoma) was declared as a separate entity in WHO classification of Tumors of Haematopoetic and Lymphoid Tissues in 2008 and 2017 years. Despite of similar pathomorphological characteristics between primary mediastinal B-cell lymphoma and Hodgkin lymphoma, clinical features and optimal therapeutic approach to MGZL are not clearly defined. Usually MGZL manifests with mediastinal lymphadenopathy, although extranodal lesions often occur (grey-zone lymphoma, GZL). Read More

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http://dx.doi.org/10.26442/00403660.2019.04.000071DOI Listing
May 2019
12 Reads

Early chemotherapy de-escalation strategy in patients with advanced-stage Hodgkin lymphoma with negative positron emission tomography scan after 2 escalated BEACOPP cycles.

Pol Arch Intern Med 2019 04 4;129(4):259-266. Epub 2019 Apr 4.

Department of Hematology, Jagiellonian University Medical College, Kraków, Poland

INTRODUCTION Escalated BEACOPP (escBEACOPP: bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) significantly improves overall response rates (ORRs) and prolongs progression‑free survival (PFS) in patients with advanced‑stage Hodgkin lymphoma (HL). However, 6 to 8 cycles of escBEACOPP are associated with increased acute toxicity and late complications. OBJECTIVES We aimed to determine the role of early positron emission tomography-computed tomography (PET‑CT) response assessment in a de‑escalation strategy. Read More

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http://dx.doi.org/10.20452/pamw.14786DOI Listing
April 2019
17 Reads

Clinical Intensity Modulated Proton Therapy for Hodgkin Lymphoma: Which Patients Benefit the Most?

Pract Radiat Oncol 2019 May 29;9(3):179-187. Epub 2019 Jan 29.

Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Oxford Cancer Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Purpose: Radiation therapy (RT) improves control of Hodgkin lymphoma (HL), but patients who undergo RT are at risk for late effects, including cardiovascular disease and second cancers, because of radiation doses to organs at risk (OARs). Proton therapy (PT) can reduce OAR doses compared with conventional photon RT. However, access to PT is currently limited, so referrals must be appropriately selective. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18798500193000
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http://dx.doi.org/10.1016/j.prro.2019.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493042PMC
May 2019
130 Reads

PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study.

Lancet Oncol 2019 02 15;20(2):202-215. Epub 2019 Jan 15.

LYSA Imaging, Hôpital H Mondor, Creteil, France.

Background: Increased-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) improves progression-free survival in patients with advanced Hodgkin lymphoma compared with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), but is associated with increased risks of haematological toxicity, secondary myelodysplasia or leukaemia, and infertility. We investigated whether PET monitoring during treatment could allow dose de-escalation by switching regimen (BEACOPP to ABVD) in early responders without loss of disease control compared with standard treatment without PET monitoring.

Methods: AHL2011 is a randomised, non-inferiority, phase 3 study done in 90 centres across Belgium and France. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30784-8DOI Listing
February 2019
18 Reads
24.690 Impact Factor

Experiences in the treatment of refractory chylothorax associated with lymphoproliferative disorders.

Orphanet J Rare Dis 2019 01 9;14(1). Epub 2019 Jan 9.

4th Department of Internal Medicine - Hematology, University Hospital, Sokolska Street 581, 5005, Hradec Kralove, Czech Republic.

Background: Chylothorax is a rare condition which can be associated with malignant lymphoproliferative disorders (LPDs). We retrospectively analyzed the results of the conservative treatment of 10 patients with persistent non-traumatic malignant chylothorax.

Results: Conservative treatment lead to a decline of chylothorax after mean of 66 days and consisted of the treatment of the underlying disease and of simultaneous long-term supportive care (drainage of the thoracic cavity, dietary measures and nutrition management). Read More

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http://dx.doi.org/10.1186/s13023-018-0991-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327395PMC
January 2019
15 Reads

Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features.

Allergy Asthma Clin Immunol 2019 5;15. Epub 2019 Jan 5.

2Department of Neuroscience, Division of Dentistry, University of Padua, Via Giustiniani 2, 35128 Padua, Italy.

Background: Melkersson-Rosenthal syndrome (MRS) is a rare, neuro-mucocutaneous disease which presents as orofacial swelling, facial palsy and fissured tongue. These symptoms may occur simultaneously or, more frequently, with a oligosymptomatic or monosymptomatic pattern. Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-018-0316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320604PMC
January 2019
33 Reads

Infection of lung cavitations in a young dog owner with Hodgkin's lymphoma caused by , without a dog bite: confirmed zoonotic transmission by tagmentation microbiome analysis.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Internal Medicine, Spaarne Gasthuis Hoofddorp, Hoofddorp, The Netherlands.

is a known pathogen in humans, mostly reported after animal bite incidents. Atraumatic infections have been described, especially in immunocompromised patients. A 20-year-old patient with a history of stage IV Hodgkin's lymphoma with cavitating pulmonary lesions presented with a bilateral pneumonia. Read More

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http://dx.doi.org/10.1136/bcr-2018-226646DOI Listing
December 2018
10 Reads

Reconstruction of anterior chest wall: a clinical analysis.

J Cardiothorac Surg 2018 Dec 7;13(1):124. Epub 2018 Dec 7.

Department of thoracic surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Objective: To investigate the methods and clinical efficacy of reconstruction of chest defects with titanium sternal fixation system after the surgical resection of sternal tumors.

Methods: A total of 6 patients with sternal tumor who were diagnosed and underwent resection and repair of the chest wall defects by titanium plates system, from 2017.3 to 2017. Read More

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https://cardiothoracicsurgery.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13019-018-0810-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286520PMC
December 2018
31 Reads
1.018 Impact Factor

Expression of the immune checkpoint receptor TIGIT in Hodgkin's lymphoma.

BMC Cancer 2018 Dec 4;18(1):1209. Epub 2018 Dec 4.

Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Hodgkin's lymphoma (HL) is characterized by a high background of inflammatory cells which play an important role for the pathogenesis of the disease. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpoint receptor and a putative target for novel immunotherapies. To study patterns of TIGIT expression in the T cell background surrounding malignant cells including Hodgkin cells, Reed-Sternberg cells and histiocytic cells, a microenvironment (ME) tissue microarray (TMA) was constructed from tissue punches measuring 2 mm in diameter obtained from formalin-fixed tissue samples of Hodgkin's lymphoma lymph nodes (n = 40) and normal human tonsil (n = 2). Read More

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http://dx.doi.org/10.1186/s12885-018-5111-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280445PMC
December 2018
51 Reads

A case of bleomycin-induced lung toxicity.

Monaldi Arch Chest Dis 2018 11 6;88(3):981. Epub 2018 Nov 6.

Istanbul University, Cerrahpasa Medical Faculty, Pulmonary Diseases Department.

A 64-year-old female was admitted for dry cough, dyspnea, fever, loss of appetite, and weight loss. Past medical history revealed scoliosis, cholecystectomy, and Hodgkin lymphoma. ABG values were: pH: 7. Read More

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http://dx.doi.org/10.4081/monaldi.2018.981DOI Listing
November 2018
7 Reads

Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report

Biomedica 2018 09 1;38(3):298-302. Epub 2018 Sep 1.

Departamento de Hemato-Patología, Fundación Valle del Lili, Cali, Colombia.

The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. Read More

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http://dx.doi.org/10.7705/biomedica.v38i3.3739DOI Listing
September 2018
29 Reads

A role for surgery in the treatment of relapsed Hodgkin lymphoma.

Pediatr Blood Cancer 2019 01 8;66(1):e27402. Epub 2018 Oct 8.

Division of General and Thoracic Surgery, Hospital for Sick Children/University of Toronto, Toronto, Canada.

Treatment of Hodgkin lymphoma (HL) has advanced over time, rendering a fatal disease now largely curable. Multiagent chemotherapy regimens, hematopoietic stem cell transplantation, and radiotherapy are the mainstays of care. Surgical intervention is rarely indicated other than for biopsy at diagnosis. Read More

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http://doi.wiley.com/10.1002/pbc.27402
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http://dx.doi.org/10.1002/pbc.27402DOI Listing
January 2019
20 Reads

Automated quantification of reference levels in liver and mediastinal blood pool for the Deauville therapy response classification using FDG-PET/CT in Hodgkin and non-Hodgkin lymphomas.

Clin Physiol Funct Imaging 2019 Jan 3;39(1):78-84. Epub 2018 Oct 3.

Department of Clinical Physiology and Nuclear Medicine, Lund University and Skåne University Hospital, Malmö, Sweden.

Background: 18F-FDG-PET/CT has become a standard for assessing treatment response in patients with lymphoma. A subjective interpretation of the scan based on the Deauville 5-point scale has been widely adopted. However, inter-observer variability due to the subjectivity of the interpretation is a limitation. Read More

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http://doi.wiley.com/10.1111/cpf.12546
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http://dx.doi.org/10.1111/cpf.12546DOI Listing
January 2019
37 Reads

Significance of pleural effusion at diagnosis in pediatric Hodgkin lymphoma: a report from Children's Oncology Group protocol AHOD0031.

Pediatr Radiol 2018 11 16;48(12):1736-1744. Epub 2018 Jul 16.

Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, NY, USA.

Background: Pleural effusion at presentation in Hodgkin lymphoma has been associated with inferior outcome but has not been systematically evaluated.

Objective: To determine whether pleural effusion at presentation in children with Hodgkin lymphoma is a primary indicator of poor prognosis or secondary to associated factors.

Materials And Methods: Children's Oncology Group (COG) AHOD0031, a randomized, response-based, centrally reviewed protocol, enrolled 1,712 eligible patients <22 years of age with initial presentation of intermediate risk, biopsy-proven Hodgkin lymphoma; 1,423 had available imaging for retrospective review. Read More

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http://dx.doi.org/10.1007/s00247-018-4197-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208959PMC
November 2018
17 Reads

A Mediastinal Mass in a Young Man.

JAMA 2018 06;319(23):2432-2433

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.7107DOI Listing
June 2018
6 Reads

Occult constrictive pericardial disease emerging 40 years after chest radiation therapy: a case report.

BMC Cardiovasc Disord 2018 05 31;18(1):107. Epub 2018 May 31.

Department of System Biology, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: The main etiology of constrictive pericarditis (CP) has changed from tuberculosis to therapeutic mediastinal radiation and cardiac surgery. Occult constrictive pericardial disease (OCPD) is a covert disease in which CP is manifested in a condition of volume overload.

Case Presentation: A 60-year-old patient with a history of thoracic radiation therapy for non-Hodgkin's lymphoma (40 years earlier) was transferred to our hospital for treatment of repeated congestive heart failure. Read More

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https://bmccardiovascdisord.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s12872-018-0848-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984425PMC
May 2018
14 Reads

Anterior mediastinal Hodgkin lymphoma presenting as an extremely hypervascular tumor on computed tomography: A case report.

Medicine (Baltimore) 2018 May;97(19):e0607

Department of Thoracic Surgery, CHA Bundang Medical Center, CHA University, Bundang-gu, Seongnam-si, Republic of Korea.

Rationale: In the thorax, Hodgkin lymphoma (HL) most frequently involves the anterior mediastinal and paratracheal regions and tends to spread to contiguous nodal groups. Enlarged lymph nodes typically have homogeneous soft tissue attenuation similar to that of muscle tissue on computed tomography (CT).

Patient Concerns: A contrast-enhanced CT examination of a 19-year-old man with right-sided chest pain showed an intense, heterogeneously enhancing mass with organization of serpentine and dilated blood vessels in the right anterior mediastinum that had invaded the upper lobe of the right lung. Read More

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http://Insights.ovid.com/crossref?an=00005792-201805110-0001
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http://dx.doi.org/10.1097/MD.0000000000010607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959439PMC
May 2018
11 Reads

Primary Spinal Lymphoma Masquerading as Meningioma: Preoperative and Postoperative Magnetic Resonance Imaging Findings.

World Neurosurg 2018 Oct 26;118:86-87. Epub 2018 Apr 26.

Department of Neurosurgery, Van Yuzuncu Yıl University, Dursun Odabası Faculty of Medicine, Van, Turkey.

A 55-year-old male who complained of frequent back pain accompanied by increasing weakness in the lower extremities was admitted to our hospital's Neurosurgery Department. No additional disease was in his history. Magnetic resonance imaging of the thoracic area, anterior epidural space, and paravertebral area revealed an approximately 55 × 9 mm lymphoma pressuring the spinal cord from the anterior. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.129DOI Listing
October 2018
8 Reads

Lactate dehydrogenase levels and 18F-FDG PET/CT metrics differentiate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma.

Nucl Med Commun 2018 Jun;39(6):572-578

Departments of Radiology, Nuclear Medicine and Molecular Imaging, Medical Imaging Center.

Purpose: This study aims to investigate whether clinical, laboratory, and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT findings can discriminate between mediastinal Hodgkin's lymphoma and primary mediastinal B-cell lymphoma (PMBCL).

Patients And Methods: This retrospective study included 56 patients (42 with mediastinal Hodgkin's lymphoma and 14 with PBMCL). Differences in clinical, laboratory, and F-FDG PET/CT metrics were assessed between Hodgkin's lymphoma and PMBCL. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000840DOI Listing
June 2018
33 Reads

Synchronous Pulmonary Neoplasms: A Chance Occurrence or is There More Than Meets the Eye?

Cureus 2018 Feb 6;10(2):e2162. Epub 2018 Feb 6.

Department of Hematology and Oncology, Staten Island University Hospital.

Primary bronchus-associated lymphoid tissue (BALT) lymphoma comprises 5% of non-Hodgkin's lymphoma (NHL) and usually has an indolent course. Synchronous primary lung cancers with BALT lymphoma are seldom seen in patients with adenocarcinoma of the lung. Synchronous squamous cell carcinoma (SCC) and BALT lymphoma is an extremely rare occurrence. Read More

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http://dx.doi.org/10.7759/cureus.2162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893181PMC
February 2018
9 Reads

Inter-patient image registration algorithms to disentangle regional dose bioeffects.

Sci Rep 2018 03 20;8(1):4915. Epub 2018 Mar 20.

Institute of Biostructures and Bioimaging, National Research Council, Napoli, Italy.

Radiation therapy (RT) technological advances call for a comprehensive reconsideration of the definition of dose features leading to radiation induced morbidity (RIM). In this context, the voxel-based approach (VBA) to dose distribution analysis in RT offers a radically new philosophy to evaluate local dose response patterns, as an alternative to dose-volume-histograms for identifying dose sensitive regions of normal tissue. The VBA relies on mapping patient dose distributions into a single reference case anatomy which serves as anchor for local dosimetric evaluations. Read More

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http://dx.doi.org/10.1038/s41598-018-23327-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861107PMC
March 2018
3 Reads

Rare case of radiation-induced primary tracheal carcinoma.

Gen Thorac Cardiovasc Surg 2018 Sep 15;66(9):549-551. Epub 2018 Mar 15.

Section of Thoracic Surgery, Yale University School of Medicine, BB205, 330 Cedar Street, New Haven, CT, 06520, USA.

Primary carcinoma of the trachea is an exceeding rare entity. We present a case of radiation-induced primary squamous cell carcinoma of the trachea in a young woman. The case highlights a diagnostic challenge of this atypical disease entity. Read More

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http://dx.doi.org/10.1007/s11748-018-0907-0DOI Listing
September 2018
6 Reads

Clinical and misdiagnosed analysis of primary pulmonary lymphoma: a retrospective study.

BMC Cancer 2018 03 12;18(1):281. Epub 2018 Mar 12.

The First Affiliated Hospital of Wenzhou Medical University & Key Laboratory of Heart and Lung, Zhejiang, 325035, China.

Background: The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and summarizes misdiagnosis reasons of PPL cases, aims to provide a better understanding and increase the accuracy of early diagnosis and minimize the misdiagnosis of PPL.

Methods: The clinical data of 19 cases were collected from the first affiliated hospital of Wenzhou medical university (PRC) from April 2010 to May 2016. Read More

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http://dx.doi.org/10.1186/s12885-018-4184-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848441PMC
March 2018
59 Reads

Hodgkin Lymphoma Presentation With Extensive Chest Wall Muscle Involvement in an Adult.

Ann Thorac Surg 2018 07 13;106(1):e37. Epub 2018 Feb 13.

Department of Radiology, Ramón y Cajal University Hospital, Madrid, Spain.

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183014
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http://dx.doi.org/10.1016/j.athoracsur.2018.01.034DOI Listing
July 2018
6 Reads
3.850 Impact Factor

Hodgkin Lymphoma revealed by epidural spinal cord compression.

J Spinal Cord Med 2019 05 30;42(3):402-404. Epub 2018 Jan 30.

a Neurosurgery Department , Institut National de Neurologie, Faculté de Médecine de Tunis , Tunisia.

Context: Hodgkin Lymphoma is rarely diagnosed as spinal cord compression syndrome. Caused by an epidural mass, this complication is often encountered in a late stage of the disease. We report the case of a 40-year-old man presenting with symptoms of low thoracic spinal cord compression due to an epidural tumor on the MRI. Read More

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http://dx.doi.org/10.1080/10790268.2018.1427519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522921PMC
May 2019
13 Reads

A Patient with Non-Hodgkin Lymphoma and Nonspecific Interstitial Pneumonia during Ibrutinib Therapy.

Case Rep Oncol Med 2017 10;2017:5640186. Epub 2017 Nov 10.

Department of Pneumology, Lungenklinik Heckeshorn, HELIOS Klinikum Emil von Behring, Berlin, Germany.

We present a 74-year-old male with nonspecific interstitial pneumonia (NSIP) during treatment with ibrutinib for mantle cell lymphoma. Previously, the patient had received six cycles of bendamustine and rituximab and six cycles of R-CHOP, followed by rituximab maintenance therapy. Respiratory tract complications of ibrutinib other than infectious pneumonia have not been mentioned in larger trials, but individual case reports hinted to a possible association with the development of pneumonitis. Read More

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http://dx.doi.org/10.1155/2017/5640186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702410PMC
November 2017
43 Reads

Comparison of 36 Gy, 20 Gy, or No Radiation Therapy After 6 Cycles of EBVP Chemotherapy and Complete Remission in Early-Stage Hodgkin Lymphoma Without Risk Factors: Results of the EORT-GELA H9-F Intergroup Randomized Trial.

Int J Radiat Oncol Biol Phys 2018 04 27;100(5):1133-1145. Epub 2017 Oct 27.

Centre de Traitement des Données du Cancéropôle Nord-Ouest, Centre François Baclesse, Caen, France. Electronic address:

Purpose: While patients with early-stage Hodgkin lymphoma (HL) have an excellent outcome with combined treatment, the radiation therapy (RT) dose and treatment with chemotherapy alone remain questionable. This noninferiority trial evaluates the feasibility of reducing the dose or omitting RT after chemotherapy.

Methods And Materials: Patients with untreated supradiaphragmatic HL without risk factors (age ≥ 50 years, 4 to 5 nodal areas involved, mediastinum-thoracic ratio ≥ 0. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2017.10.015DOI Listing
April 2018
59 Reads

Different manifestation of irradiation induced coronary artery disease detected with coronary computed tomography compared with matched non-irradiated controls.

Radiother Oncol 2017 10 4;125(1):55-61. Epub 2017 Oct 4.

Department of Cardiology, Leiden University Medical Center, The Netherlands. Electronic address:

Background And Purpose: Patients who received chest irradiation for treatment of a malignancy are at increased risk for the development of coronary artery atherosclerosis. Little is known about the anatomical coronary artery plaque characteristics of irradiation induced coronary artery disease (CAD). This study aimed to evaluate potential differences in the presence, extent, severity, composition and location of CAD in patients treated with mediastinal irradiation compared with non-irradiated controls matched on age, gender and cardiovascular risk factors. Read More

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http://dx.doi.org/10.1016/j.radonc.2017.09.008DOI Listing
October 2017
22 Reads

Pulmonary Toxicity Following Proton Therapy for Thoracic Lymphoma.

Int J Radiat Oncol Biol Phys 2017 10 11;99(2):494-497. Epub 2017 Apr 11.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2017.04.001DOI Listing
October 2017
21 Reads

The risk of reoperative cardiac surgery in radiation-induced valvular disease.

J Thorac Cardiovasc Surg 2017 12 29;154(6):1883-1895. Epub 2017 Jul 29.

Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

Objective: Mediastinal radiation therapy (MRT) increases the risk for adverse outcomes after cardiac surgery and is not incorporated in the Society of Thoracic Surgeons (STS) risk algorithm. We aimed to quantify the surgical risk conferred by MRT in patients undergoing primary and reoperative valvular operations.

Methods: A retrospective analysis of 261 consecutive patients with prior MRT who underwent valvular operations between January 2002 and May 2015. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2017.07.033DOI Listing
December 2017
42 Reads
4.168 Impact Factor

[Doses to organs at risk in conformational radiotherapy and stereotaxic irradiation: The heart].

Cancer Radiother 2017 Oct 1;21(6-7):626-635. Epub 2017 Sep 1.

Département d'oncologie radiothérapie, institut Curie, 26, rue d'Ulm, 75005 Paris, France.

Radiation therapy of breast cancer, Hodgkin lymphoma, lung cancer and others thoracic irradiations induce an ionizing radiation dose to the heart. Irradiation of the heart, associated with patient cardiovascular risk and cancer treatment-induced cardiotoxicity, increase cardiovascular mortality. The long survival after breast or Hodgkin lymphoma irradiation requires watching carefully late treatment toxicity. Read More

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http://dx.doi.org/10.1016/j.canrad.2017.07.044DOI Listing
October 2017
6 Reads

[A case of severe left main isolated stenosis in a young woman with previous history of non-Hodgkin lymphoma].

G Ital Cardiol (Rome) 2017 Sep;18(9):668-671

U.O.C. Cardiologia, Dipartimento Cardio-Nefro-Polmonare, Azienda Ospedaliero-Universitaria di Parma.

We report the case of a 34-year-old female treated with radiotherapy and chemotherapy for non-Hodgkin lymphoma at the age of 16. The patient came to our attention because of progressive dyspnea on effort and a positive result on a pharmacologic stress echo test. Coronary angiography revealed focal critical ostial stenosis of the left main coronary artery. Read More

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http://dx.doi.org/10.1714/2741.27951DOI Listing
September 2017
11 Reads

Chest wall lymphomas: Fine needle aspiration cytodiagnosis and review of the literature.

Cytopathology 2017 Oct 21;28(5):364-370. Epub 2017 Jul 21.

Cytology Unit, Mubarak Al-Kabeer Hospital, Al-Jabriya, Kuwait.

Objective: Compared to other chest wall malignancies, lymphoma is a common disease. However, published literature on a series of lymphoma cases involving the chest wall is scarce. The aim of the present study, was to describe experience with chest wall swellings diagnosed as lymphoid neoplasms on fine needle aspiration (FNA) cytology. Read More

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http://dx.doi.org/10.1111/cyt.12433DOI Listing
October 2017
7 Reads

Late Cardiac Toxicity After Mediastinal Radiation Therapy for Hodgkin Lymphoma: Contributions of Coronary Artery and Whole Heart Dose-Volume Variables to Risk Prediction.

Int J Radiat Oncol Biol Phys 2017 08 27;98(5):1116-1123. Epub 2017 Mar 27.

Radiation Medicine Program, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada; Pediatric Oncology Group of Ontario, Toronto, Ontario, Canada. Electronic address:

Purpose: Mediastinal radiation therapy (RT) for Hodgkin lymphoma (HL) is associated with late cardiotoxicity, but there are limited data to indicate which dosimetric parameters are most valuable for predicting this risk. This study investigated which whole heart dosimetric measurements provide the most information regarding late cardiotoxicity, and whether coronary artery dosimetry was more predictive of this outcome than whole heart dosimetry.

Methods And Materials: A random sample of 125 HL patients treated with mediastinal RT was selected, and 3-dimensional cardiac dose-volume data were generated from historical plans using validated methods. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016173071
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http://dx.doi.org/10.1016/j.ijrobp.2017.03.026DOI Listing
August 2017
10 Reads

Dual-Energy CT: New Horizon in Medical Imaging.

Korean J Radiol 2017 Jul-Aug;18(4):555-569. Epub 2017 May 19.

Department of Radiology, Seoul National University College of Medicine, Seoul 03080, Korea.

Dual-energy CT has remained underutilized over the past decade probably due to a cumbersome workflow issue and current technical limitations. Clinical radiologists should be made aware of the potential clinical benefits of dual-energy CT over single-energy CT. To accomplish this aim, the basic principle, current acquisition methods with advantages and disadvantages, and various material-specific imaging methods as clinical applications of dual-energy CT should be addressed in detail. Read More

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http://dx.doi.org/10.3348/kjr.2017.18.4.555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447632PMC
October 2017
30 Reads

ABVD or BEACOPP along with involved-field radiotherapy in early-stage Hodgkin Lymphoma with risk factors: Results of the European Organisation for Research and Treatment of Cancer (EORTC)-Groupe d'Étude des Lymphomes de l'Adulte (GELA) H9-U intergroup randomised trial.

Eur J Cancer 2017 08 8;81:45-55. Epub 2017 Jun 8.

Centre de Traitement des Données du Cancéropôle Nord-Ouest, Centre François Baclesse, 3 Avenue Général Harris, 14076 Caen Cedex 05, France. Electronic address:

Purpose: For early-stage Hodgkin lymphoma (HL), optimal chemotherapy regimen and the number of cycles to be delivered remain to settle down. The H9-U trial compared three modalities of chemotherapy followed by involved-field radiotherapy (IFRT) in patients with stage I-II HL and risk factors (NCT00005584).

Patients And Methods: Patients aged 15-70 years with untreated supradiaphragmatic HL with at least one risk factor (age ≥ 50, involvement of 4-5 nodal areas, mediastinum/thoracic ratio ≥ 0. Read More

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http://dx.doi.org/10.1016/j.ejca.2017.05.005DOI Listing
August 2017
122 Reads