81,461 results match your criteria Hodgkin Disease Thoracic


Dissecting Clonal Hematopoiesis in Tissues of Classical Hodgkin Lymphoma Patients.

Blood Cancer Discov 2021 May 10;2(3):216-225. Epub 2021 Apr 10.

Institute of Hematology and Center for Hemato-Oncology Research, University and Hospital of Perugia - Italy.

Clonal hematopoiesis predisposes to hematological malignancies. However, clonal hematopoiesis is understudied in classical Hodgkin lymphoma (cHL), a mature B-cell neoplasm exhibiting the most abundant microenvironment. We analyzed clonal hematopoiesis in 40 cHL cases by sequencing microdissected tumor cells and matched normal cells from blood and/or lymph nodes. Read More

View Article and Full-Text PDF

Query-guided protein-protein interaction inhibitor discovery.

Chem Sci 2021 Mar 2;12(13):4753-4762. Epub 2021 Mar 2.

Astbury Centre for Structural Molecular Biology, University of Leeds Woodhouse Lane Leeds LS2 9JT UK

Protein-protein interactions (PPIs) are central to biological mechanisms, and can serve as compelling targets for drug discovery. Yet, the discovery of small molecule inhibitors of PPIs remains challenging given the large and typically shallow topography of the interacting protein surfaces. Here, we describe a general approach to the discovery of orthosteric PPI inhibitors that mimic specific secondary protein structures. Read More

View Article and Full-Text PDF

Gate Mechanism and Parameter Analysis of Anodal-First Waveforms for Improving Selectivity of C-Fiber Nerves.

J Pain Res 2021 15;14:1785-1807. Epub 2021 Jun 15.

Graduate School of Science and Engineering, Chiba University, Chiba, Japan.

Purpose: Few investigations have been conducted on the selective stimulation of small-radius unmyelinated C nerves (), which are critical to both the recovery of damaged nerves and pain suppression. The purpose of this study is to understand how an anodal pulse in an anodal-first stimulation could improve -selectivity over myelinated nociceptive Aδ nerves () and to further clarify the landscape of the solution space.

Materials And Methods: An adapted Hodgkin-Huxley (HH) model and the McIntyre-Richardson-Grill (MRG) model were used for modeling and , respectively, to analyze the underlying ion dynamics and the influence of relevant stimulation waveforms, including monopolar, polarity-symmetric, and asymmetric pulses. Read More

View Article and Full-Text PDF

Older patients (aged ≥60 years) with previously untreated advanced-stage classical Hodgkin lymphoma: a detailed analysis from the phase III ECHELON-1 study.

Haematologica 2021 Jun 24. Epub 2021 Jun 24.

Research and Innovation Department, A Lacassagne Cancer Centre, Nice.

Effective and tolerable treatments are needed for older patients with classical Hodgkin lymphoma (cHL). We report results for older patients with cHL treated in the large phase III ECHELON-1 study of frontline brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (A+AVD) versus doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). Modified progression-free survival (PFS) per independent review facility (IRF) for older versus younger patients (aged ≥60 versus. Read More

View Article and Full-Text PDF

Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness.

Yeungnam Univ J Med 2021 Jul 15;38(3):258-263. Epub 2021 Apr 15.

Department of Rehabilitation Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.

Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation or recurrence. It affects various peripheral nervous structures and can therefore mimic disc-related nerve root pathology or compressive mononeuropathy. Read More

View Article and Full-Text PDF

Endoscopic endonasal approach to the cavernous sinus Epstein-Barr virus-positive B cell non-Hodgkin lymphoma in a child: case report.

Childs Nerv Syst 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery, Gulhane School of Medicine, University of Health Sciences, Ankara, Turkey.

Cavernous sinus (CS) lymphoma without paranasal sinuses involvement is extremely rare in pediatric population and remains a diagnostic challenge due to its similarity to other tumors located in this area. An 8-year-old boy presented with a 6-day history of gradually developing ptosis in the right eyelid. After admission, his symptoms progressed within 24 h to include right-sided ophthalmoplegia consisting of oculomotor and abducens nerve palsies. Read More

View Article and Full-Text PDF

[Lymphoma in children and adolescents].

Radiologe 2021 Jun 23. Epub 2021 Jun 23.

Institut für Kinderradiologie, Universitätsklinikum Leipzig, Liebigstraße 20a, 04103, Leipzig, Deutschland.

Clinical/methodological Issue: Lymphoma is the third most common neoplasm in children. Detection, accurate staging, and restaging are important for all radiologists involved in the diagnosis of children.

Standard Radiological Methods: Magnetic resonance imaging (MRI), positron emission tomography/computed tomography (PET/CT), CT, ultrasound, X‑ray. Read More

View Article and Full-Text PDF

Renal Lymphoma Mimicking a Retroperitoneal Hematoma.

Cureus 2021 May 18;13(5):e15099. Epub 2021 May 18.

Radiology, Hospital Beatriz Ângelo, Loures, PRT.

We report the case of a 65-year-old female with an atypical presentation of renal lymphoma at computed tomography (CT), which was initially misinterpreted as a retroperitoneal hematoma. This case highlights the importance to keep a high level of suspicion in order to make a prompt diagnosis since treatment strategies differ significantly. Read More

View Article and Full-Text PDF

Targeting TfR1 with the ch128.1/IgG1 antibody inhibits EBV driven lymphomagenesis in immunosuppressed mice bearing EBV+ human primary B-cells.

Mol Cancer Ther 2021 Jun 22. Epub 2021 Jun 22.

Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA.

Epstein-Barr virus (EBV) is a human gammaherpesvirus associated with the development of hematopoietic cancers of B-lymphocyte origin, including AIDS-related non-Hodgkin lymphoma (AIDS-NHL). Primary infection of B-cells with EBV results in their polyclonal activation and immortalization. The transferrin receptor 1 (TfR1), also known as CD71, is important for iron uptake and regulation of cellular proliferation. Read More

View Article and Full-Text PDF

The Impact of Prior Salvage Treatment With Immune Checkpoint Inhibitors on Hodgkin Lymphoma Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Single-Center Experience.

Clin Lymphoma Myeloma Leuk 2021 May 19. Epub 2021 May 19.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.

Introduction: The objective of the study was to assess the impact of the previous use of immune-checkpoint inhibitors (ICIs) on the clinical course of Hodgkin Lymphoma (HL) patients undergoing autologous hematopoietic stem cell transplantation (ASCT).

Methods: A single-center, retrospective chart review of adult HL patients who received ASCT from January 1, 2014, to December 31, 2019, was conducted. Primary endpoints included the length of stay (LOS) and the composite outcome of late-onset noninfectious fever (LONIF) or late-onset hypotension (LOH) requiring intravenous fluid (IVF) resuscitation. Read More

View Article and Full-Text PDF

Endosonography-Guided Biopsy as a First Test in the Diagnosis of Lymphoma.

Semin Thorac Cardiovasc Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of Surgery, Division of Thoracic Surgery, CHUM Endoscopic Tracheobronchial and Oesophageal Center (CETOC), University of Montreal, Montreal, Quebec, Canada. Electronic address:

To evaluate the diagnostic accuracy of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) and Endoscopic Ultrasound-guided Fine Needle Aspiration (EUS-FNA) in the diagnosis of lymphoma. A retrospective analysis of patients with suspected mediastinal lymphoproliferative disorders who underwent EBUS-TBNA, EUS-FNA or combined procedures from 2009 to 2019 was conducted using a prospectively maintained interventional thoracic endoscopy database. Demographic data, imaging, needle size, surgical biopsy, complications rate and pathology reports were reviewed. Read More

View Article and Full-Text PDF

Gonadal Function Recovery in Patients With Advanced Hodgkin Lymphoma Treated With a PET-Adapted Regimen: Prospective Analysis of a Randomized Phase III Trial (AHL2011).

J Clin Oncol 2021 Jun 22:JCO2100068. Epub 2021 Jun 22.

Department of Haematology, University Hospital F Mitterrand and Inserm UMR1231, Dijon, France.

Purpose: The prospective, randomized AHL2011 trial demonstrated that the use of the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen (ABVD) after two cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) in early responders on the basis of a positron emission tomography (PET)-driven strategy was safe and minimized toxicity compared with standard 6 BEACOPP cycles. This substudy investigated the benefit of this strategy in gonadal function and fertility in patients under 45 years old.

Methods: Ovarian function was assessed by serum measurement of follicle-stimulating hormone (FSH), estradiol, and anti-müllerian hormone in women, and semen analysis, FSH, and testosterone levels were used to evaluate testicular function in men at baseline, end of treatment, and during 5 years of follow-up. Read More

View Article and Full-Text PDF

Soil, senescence and exudate utilisation: characterisation of the Paragon var. spring bread wheat root microbiome.

Environ Microbiome 2021 Jun 21;16(1):12. Epub 2021 Jun 21.

Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich, NR4 7UH, UK.

Background: Conventional methods of agricultural pest control and crop fertilisation are unsustainable. To meet growing demand, we must find ecologically responsible means to control disease and promote crop yields. The root-associated microbiome can aid plants with disease suppression, abiotic stress relief, and nutrient bioavailability. Read More

View Article and Full-Text PDF

Phase I study protocol: NKTR-255 as monotherapy or combined with daratumumab or rituximab in hematologic malignancies.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

NKTR-255 is an investigational polyethylene glycol-modified recombinant human IL-15 (rhIL-15) receptor agonist, designed to improve the immunotherapeutic and anti-cancer benefit observed with rhIL-15 while circumventing the toxicities associated with this therapy. In preclinical studies, NKTR-255 has demonstrated enhanced proliferation and function of CD8 T cells and natural killer cells, as well as enhanced anti-tumor activity and survival both as monotherapy and in combination with monoclonal antibodies in multiple cancer models. Here, we describe the rationale and design of the first-in-human Phase I, dose-escalation and dose-expansion study of NKTR-255 alone and in combination with daratumumab or rituximab in adults with relapsed/refractory multiple myeloma or non-Hodgkin's lymphoma that will determine the maximum tolerated dose and recommended Phase II dose for NKTR-255. Read More

View Article and Full-Text PDF

PD-1 and PD-L1 inhibitors foster the progression of adult T-cell Leukemia/Lymphoma.

Int Immunopharmacol 2021 Jun 18;98:107870. Epub 2021 Jun 18.

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Immunotherapy through immune checkpoints blockade and its subsequent clinical application has revolutionized the treatment of a spectrum of solid tumors. Blockade of Programmed cell death protein-1 and its ligand has shown promising results in clinical studies. The clinical trials that enrolled patients with different hematopoietic malignancies including non-Hodgkin lymphoma, Hodgkin lymphoma, and acute myeloid leukemia (AML) showed that anti-PD-1 agents could have potential therapeutic effects in the patients. Read More

View Article and Full-Text PDF

Racial and ethnic disparities in pediatric cancer incidence among children and young adults in the United States by single year of age.

Cancer 2021 Jun 21. Epub 2021 Jun 21.

Division of Pediatric Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

Background: Incidence rates of pediatric cancers in the United States are typically reported in 5-year age groups, obscuring variation by single year of age. Additionally, racial and ethnic variation in incidence is typically presented in broad categories rather than by narrow age ranges.

Methods: The Surveillance, Epidemiology, and End Results (SEER) 18 data (2000-2017) were examined to calculate frequencies and age-adjusted incidence rates among individuals aged birth to 39 years. Read More

View Article and Full-Text PDF

Graft Failure in Patients With Hematological Malignancies: A Successful Salvage With a Second Transplantation From a Different Haploidentical Donor.

Front Med (Lausanne) 2021 4;8:604085. Epub 2021 Jun 4.

Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, National Clinical Research Center for Hematologic Disease, Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.

Graft failure (GF) is a fatal complication of allogeneic stem cell transplantation, especially after haploidentical transplantation. The mortality of GF is nearly 100% without an effective salvage method. A second transplantation is usually necessary to save the patient's life. Read More

View Article and Full-Text PDF

Major Differences in Lymphocyte Subpopulations Between Cerebrospinal Fluid and Peripheral Blood in Non-Hodgkin Lymphoma Without Leptomeningeal Involvement: Flow Cytometry Evidence of a Cerebral Lymphatic System.

Front Oncol 2021 3;11:685786. Epub 2021 Jun 3.

Department of Research and Clinical Oncology, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Cerebrospinal fluid (CSF) flow cytometry has a crucial role in the diagnosis of leptomeningeal disease in onco-hematology. This report describes the flow cytometry characterization of 138 CSF samples from patients affected by non-Hodgkin lymphoma, negative for disease infiltration. The aim was to focus on the CSF non-neoplastic population, to compare the cellular composition of the CSF with paired peripheral blood samples and to document the feasibility of flow cytometry in hypocellular samples. Read More

View Article and Full-Text PDF

Histomorphological and Morphometric Evaluation of Microvessel Density in Nodal Non-Hodgkin Lymphoma Using CD34 and CD105.

J Lab Physicians 2021 Mar 22;13(1):22-28. Epub 2021 May 22.

Department of Pathology, Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.

 Expression of angiogenic markers determined by microvessel density (MVD) could be used as a reliable predictor of prognosis and as a potential target for antiangiogenic therapy in different categories of non-Hodgkin lymphoma (NHL).  The aim of this study was to evaluate MVD using immunohistochemical methods and computer-assisted quantitative image analysis in nodal NHL patients and compare CD34 and CD105 expression in lymph nodes of NHL patients.  The present study was conducted on 60 lymph node biopsies received in the Department of Pathology at our tertiary care center for histopathological examination. Read More

View Article and Full-Text PDF

EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disorders.

Virchows Arch 2021 Jun 19. Epub 2021 Jun 19.

Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne, University Hospital (CHUV) and Lausanne University (UNIL), Rue du Bugnon 25, CH-1011, Lausanne, Switzerland.

Intravascular large B-cell lymphoma is a rare and aggressive EBV-negative large B-cell lymphoma with a dismal outcome. Here, we describe the case of a 76-year-old HIV-positive patient with an acute presentation of systemic symptoms and rapidly fatal outcome. Autopsy revealed a disseminated large B-cell lymphoma with an intravascular distribution involving the liver, lymph nodes, spleen, and bone marrow and associated to fibrin thrombi in hepatic capillary haemangiomas. Read More

View Article and Full-Text PDF

Overview and recent advances in PET/CT imaging in lymphoma and multiple myeloma.

Eur J Radiol 2021 May 27;141:109793. Epub 2021 May 27.

IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Nuclear Medicine, via Massarenti 9, 40138, Bologna, Italy; Nuclear Medicine, DIMES, Alma Mater studiorum, Università di Bologna, Bologna, Italy. Electronic address:

Imaging in hematological diseases has evolved extensively over the past several decades. Positron emission tomography/computed tomography (PET/CT) with of 2-[18 F]-fluoro-2-deoxy-d-glucose ([18 F] FDG) is currently essential for accurate staging and for early and late therapy response assessment for all FDG-avid lymphoproliferative histologies. The widely adopted visual Deauville 5-point scale and Lugano Classification recommendations have recently standardized PET scans interpretation and improved lymphoma patient management. Read More

View Article and Full-Text PDF

Emergency Fertility Preservation in a Young Woman With Non-Hodgkin Lymphoma.

Oncology (Williston Park) 2021 Jun 19;35(6):332-334. Epub 2021 Jun 19.

Department of Obstetrics & Gynecology, University of Cologne, Cologne, Germany.

A nulliparous woman, age 25 years, had received a diagnosis of non-Hodgkin lymphoma (NHL) and now presented with stage IIA diffuse large B-cell lymphoma (DLBCL). According to her hematological oncologist's treatment plan, chemotherapy had to start immediately (within 1 week), with the patient receiving 6 courses of the standard R-CHOEP21 regimen (rituximab 375 mg/m², cyclophosphamide 750 mg/m², hydroxydaunorubicin 50 mg/m², vincristine 1.4 mg/m², etoposide 100 mg/m², prednisone 40 mg/m²). Read More

View Article and Full-Text PDF

Fried egg sign: A typical ultrasonography feature of neurolymphomatosis.

J Clin Ultrasound 2021 Jun 17. Epub 2021 Jun 17.

Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

Neurolymphomatosis (NL) is a rare condition caused by non-Hodgkin's lymphoma or leukemia. We present a case of NL and describe ultrasound features, including the "fried egg sign" in which there is a clear demarcation between an avascular echogenic core and a hypoechoic vascularized peripheral zone that may help to distinguish NL from primary nerve sheath tumors. Read More

View Article and Full-Text PDF

Incidence and Risk Factors Associated with Infection after Chimeric Antigen Receptor T Cell Therapy for Relapsed/Refractory B-cell Malignancies.

Cell Transplant 2021 Jan-Dec;30:9636897211025503

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Chimeric antigen receptor T cells (CAR-Ts) constitute a novel therapeutic strategy for relapsed/refractory B-cell malignancies. With the extensive application of CAR-T therapy in clinical settings, CAR-T-associated toxicities have become increasingly apparent. However, information regarding the associated infections is limited. Read More

View Article and Full-Text PDF

Modelling the interplay between the CD4[Formula: see text]/CD8[Formula: see text] T-cell ratio and the expression of MHC-I in tumours.

J Math Biol 2021 Jun 18;83(1). Epub 2021 Jun 18.

Department of Mathematics, King's College London, Strand, London, WC2R 2LS, UK.

Describing the anti-tumour immune response as a series of cellular kinetic reactions from known immunological mechanisms, we create a mathematical model that shows the CD4[Formula: see text]/CD8[Formula: see text] T-cell ratio, T-cell infiltration and the expression of MHC-I to be interacting factors in tumour elimination. Methods from dynamical systems theory and non-equilibrium statistical mechanics are used to model the T-cell dependent anti-tumour immune response. Our model predicts a critical level of MHC-I expression which determines whether or not the tumour escapes the immune response. Read More

View Article and Full-Text PDF

Exposure to glyphosate and risk of non-Hodgkin lymphoma: an updated meta-analysis.

Med Lav 2021 Jun 15;112(3):194-199. Epub 2021 Jun 15.

Department of Pediatrics and Public Health, University of Turin, Italy.

Objective: We updated a recent systematic review and meta-analysis of epidemiologic studies to help clarifying the association between exposure to glyphosate and risk of non-Hodgkin lymphoma (NHL).

Methods: We conducted an updated search of the literature, and identified a total of 15 relevant publications, from which we extracted results from six non-overlapping studies. We performed random-effects meta-analyses for ever-exposure to glyphosate, dose-response, and risk of specific NHL subtypes Results: The meta-RR for ever-exposure to glyphosate was 1. Read More

View Article and Full-Text PDF

Bilateral Primary testicular diffuse large B-CELL lymphoma.

Urol Case Rep 2021 Sep 28;38:101733. Epub 2021 May 28.

Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Italy.

Bilateral Primary testicular lymphoma (PTL) is a rare and aggressive non-Hodgkin extranodal lymphoma. Despite this low overall incidence, it is the most common testicular cancer in the elderly. PTL is characterized by spreading to non-contiguous extranodal sites (especially in SNC), high recurrence rate and poor prognosis. Read More

View Article and Full-Text PDF
September 2021

A rare case of the superior vena cava obstruction in a 16-year-old boy with Burkitt's lymphoma: A case report.

J Taibah Univ Med Sci 2021 Jun 7;16(3):465-469. Epub 2021 Jan 7.

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, KSA.

Burkitt's lymphoma (BL) is an aggressive non-Hodgkin B-cell lymphoma. Superior vena cava obstruction (SVCO) is considered a rare presentation of BL and it is usually associated with other types of non-Hodgkin lymphoma such as diffuse large-cell. We report a rare case of sporadic BL with SVCO in a 16-year-old boy with nasopharyngeal, mediastinal, and adrenal masses. Read More

View Article and Full-Text PDF

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified.

Nat Commun 2021 06 17;12(1):3705. Epub 2021 Jun 17.

Laboratory for Experimental Hematology, KU Leuven, Leuven, Belgium.

Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, we perform RNA-sequencing of 18 cases and validate results in an independent cohort of 37 PTCL cases. Read More

View Article and Full-Text PDF