972,423 results match your criteria History of Psychiatry[Journal]


[Consult Your Physician or Health Care Provider? Health and Legal Aspects Regarding the Use of Dietary Supplements Offered in the World Wide Web].

Sportverletz Sportschaden 2018 Dec 11;32(4):264-271. Epub 2018 Dec 11.

Hochschule für öffentliche Verwaltung und Finanzen Ludwigsburg.

Background:  In Germany, widespread use is made of dietary supplements (DS) to improve the individual health status, especially among patients diagnosed with certain conditions, elderly people and athletes. Legal aspects as well as health risks related to DS purchased via the internet are rarely analysed in Germany.

Purpose:  We aim to provide a review of the respective literature focusing on health risks, legal aspects und consumer information related to the internet retailing of DS. Read More

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December 2018
3 Reads

Renal Functions and Prognosis Stratification in Chronic Heart Failure Patients and the Importance of Neutrophil Gelatinase-Associated Lipocalin.

Kidney Blood Press Res 2018 Dec 7;43(6):1865-1877. Epub 2018 Dec 7.

Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Background/aims: The rate of incidence and prevalence of acute kidney injury is increasing due to an increased number of patients with heart failure. Therefore it is very pertinent to early detect the level of renal injuries and to make necessary heart failure predictions. Thus the aim of this study is to determine renal functions and prognosis stratification in chronic heart failure patients and importance of Neutrophil Gelatinase-Associated Lipocalin (NGAL), an early diagnostic marker of acute kidney injury, as well as stratification of cardiovascular risk in heart failure patients. Read More

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December 2018

Habit-like attention.

Curr Opin Psychol 2018 Nov 30;29:65-70. Epub 2018 Nov 30.

Department of Psychology, University of Minnesota, United States.

The control of selective attention is traditionally considered to be either goal-driven or stimulus-driven. Increasing research, however, has linked past experience to attentional selection. Effects of selection history may be transient, as in inter-trial priming, or durable. Read More

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November 2018
1 Read

Is China's coastal engineered defences valuable for storm protection?

Sci Total Environ 2018 Nov 28;657:103-107. Epub 2018 Nov 28.

Australian National University, Canberra, ACT 2601, Australia; National Taiwan University, Taipei 10617, Taiwan, ROC.

China has a long history of building hard engineered coastal defences for storm protection, which enables us to examine the economic effects of the hard engineering to mitigate storm damage. Examining historical storm impacts between 1989 and 2016, a significant negative relationship exists between the relative economic damages (i.e. Read More

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November 2018
1 Read

Distal Thrombectomy for Acute Anterior Circulation Stroke with Chronic Large Vessel Occlusion.

World Neurosurg 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, 250014, Shandong, China. Electronic address:

Background: Endovascular therapy has been increasingly recommended for the treatment of acute ischemic stroke with large vessel occlusion of the anterior circulation. However, occlusions of the distal cerebral artery are not uncommon and may cause clinical deficits, especially when combined with ipsilateral chronic large vessel occlusion. Therefore, in this patient population, the recognition of chronic occlusion and recanalization of the distal occlusive artery might be of great value for flow compensation. Read More

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December 2018
1 Read

Lens dose-response prediction modeling and cataract incidence in retinoblastoma patients after lens-sparing or whole-eye radiotherapy.

Int J Radiat Oncol Biol Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiation Oncology, Keck School of Medicine of USC and Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:

Purpose: We retrospectively assessed the incidence of cataracts in retinoblastoma (Rb) patients treated with either lens-sparing (LSRT) or whole-eye radiotherapy (WERT). A secondary aim of this study was to model the dose-response risk of cataract.

Methods: We reviewed 65 retinoblastoma patients treated with radiotherapy (RT) at XXXX from 1997-2015. Read More

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December 2018

Literature review of apheresis procedures performed perioperatively in cardiac surgery for ASFA category indications.

J Clin Apher 2018 Dec 8. Epub 2018 Dec 8.

Department of Clinical Hematology - Blood Bank and Hemostasis, Onassis Cardiac Surgery Center, Kallithea, Greece.

Background: Perioperative therapeutic plasma exchange in patients with cardiovascular diseases poses several challenges, including alterations in intravascular volume, serum electrolytes, the coagulation cascade, and drug pharmacokinetics.

Methods: This review article summarizes different indications of plasma exchange for patients requiring cardiac surgery based on reported case reports and case series.

Results: The most common reported indication is plasma exchange for the management of allosensitized cardiac transplant candidate patients in combination with immunosuppressive regimens, which increases the likelihood of obtaining a cross-match-negative allograft, improving post-transplant clinical outcome. Read More

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December 2018

Models.

Acta Physiol (Oxf) 2018 Dec 7:e13237. Epub 2018 Dec 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Vegetative Physiology.

A look at the history of science supports this statement. Harvey's discovery of the blood circulation, published in 1628, is undoubtedly among the most important events in the history of physiology. Although Harvey's concept of blood circulation was brilliant at that time, it was far away from a comprehensive insight into the circulatory system. Read More

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December 2018

Incidence and risk factors of preterm premature rupture of membranes in singleton pregnancies at Siriraj Hospital.

J Obstet Gynaecol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To obtain the incidence of preterm premature rupture of membranes (PPROM) at Siriraj Hospital during 2012-2016 and to identify its possible risk factors in singleton pregnancies.

Methods: This study was a retrospective case-control study. The institutional ethical committee has approved the study. Read More

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December 2018

Adult type rhabdomyoma presenting as a parathyroid adenoma.

Head Neck 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Adult-type rhabdomyoma (ATR) is a rare mesenchymal tumor of skeletal muscle differentiation. Extracardiac ATR occurs most commonly in the head and neck, but do so in a heterogeneous fashion, arising at numerous different locations within this region.

Methods: At our institution, we encountered a patient who was diagnosed clinically with parathyroid adenoma based on signs and symptoms of hyperparathyroidism and suggestive radiologic findings. Read More

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December 2018

Cutaneous malignant melanoma of the oral cavity following skin graft reconstruction: Case report.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.

Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.

Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More

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December 2018
1 Read

Prognostic implications of markers of the metabolic phenotype in human cutaneous melanoma.

Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.

Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.

Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More

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December 2018
1 Read

The evolutionary relationship between beak shape, mechanical advantage, and feeding ecology in modern birds.

Evolution 2018 Dec 8. Epub 2018 Dec 8.

School of Earth Sciences, University of Bristol, Life Sciences Building, Bristol, UK.

Extensive research on avian adaptive radiations has led to a presumption that beak morphology predicts feeding ecology in birds. However, this ecomorphological relationship has only been quantified in a handful of avian lineages, where associations are of variable strength, and never at a broad macroevolutionary scale. Here, we used shape analysis and phylogenetic comparative methods to quantify the relationships between beak shape, mechanical advantage, and two measures of feeding ecology (feeding behaviour and semi-quantitative dietary preferences) in a broad sample of modern birds, comprising most living orders. Read More

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December 2018

Towards the 150th anniversary of the Markovnikov's rule.

Angew Chem Int Ed Engl 2018 Dec 10. Epub 2018 Dec 10.

Moscow State University, Chemistry, RUSSIAN FEDERATION.

The Markovnikov rule, known to every student of organic chemistry, was formulated 150 years ago, in 1869. During its long history (almost as long as the history of organic chemistry itself) attitudes towards this famous statement of chemical reactivity have evolved from indifference up to the 1930s, through common acceptance as a useful educational paradigm with a marginal use in research until the 1990s, to its vigorous re-launch as an important marker of regioselectivity in the last few decades. The unexpected new popularity of the classical rule is accounted for by a rapid expansion of catalytic addition reactions and their critical importance as highly effective atom-economical, regioselective methods in modern organic synthesis. Read More

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December 2018

The importance and adaptive value of life-history evolution for metapopulation dynamics.

J Anim Ecol 2018 Nov 22. Epub 2018 Nov 22.

Department of Biology, Research Group Phycology - Bioinformatics & Evolutionary Genomics, Ghent University, Ghent, Belgium.

The spatial configuration and size of patches influence metapopulation dynamics by altering colonisation-extinction dynamics and local density dependency. This spatial forcing as determined by the metapopulation typology then imposes strong selection pressures on life-history traits, which will in turn feed back on the ecological metapopulation dynamics. Given the relevance of metapopulation persistence for biological conservation, and the potential rescuing role of evolution, a firm understanding of the relevance of these eco-evolutionary processes is essential. Read More

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November 2018
2 Reads

How mountains shape biodiversity: the role of the Andes in biogeography, diversification and reproductive biology in South America's most species rich lizard radiation (Squamata: Liolaemidae).

Evolution 2018 Dec 11. Epub 2018 Dec 11.

Division of Ecology and Evolution, Research School of Biology, The Australian National University, 0200, Canberra, ACT, Australia.

Testing hypotheses on the drivers of clade evolution and trait diversification provides insight into many aspects of evolutionary biology. Often, studies investigate only the intrinsic biological properties of organisms as the causes of diversity, however extrinsic properties of a clade's environment, particularly geological history, may also offer compelling explanations. The Andes are a young mountain chain known to have shaped many aspects of climate and diversity of South America. Read More

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December 2018

Characterization of Campylobacter jejuni, Campylobacter upsaliensis, and a novel Campylobacter sp. in a captive non-human primate zoological collection.

J Med Primatol 2018 Dec 9. Epub 2018 Dec 9.

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Background: The aim of this study was to longitudinally investigate the prevalence and characterization of Campylobacter spp. from non-human primates primate (NHP) with a history of endemic diarrhea housed at Como Park Zoo.

Methods: Fecal samples from 33 symptom-free NHP belonging to eight different species were collected weekly for 9 weeks. Read More

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December 2018
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Saws, scissors and sharks: Late Paleozoic experimentation with symphyseal dentition.

Anat Rec (Hoboken) 2018 Dec 8. Epub 2018 Dec 8.

CR2P UMR 7207 (MNHN, CNRS, UPMC, Sorbonne Université), Département Origines et Evolution, Muséum National d'Histoire naturelle, CP 48, 57 rue Cuvier, F-75231 Paris cedex 05, France.

Sharks of Late Paleozoic oceans evolved unique dentitions for catching and eating soft bodied prey. A diverse but poorly preserved clade, edestoids are noted for developing biting teeth at the midline of their jaws. Helicoprion has a continuously growing root to accommodate more than 100 crowns that spiraled on top of one another to form a symphyseal whorl supported and laterally braced within the lower jaw. Read More

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December 2018
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Persistence of a pacemaker lead-like "ghost" 6 months after lead extraction.

Echocardiography 2018 Dec 9. Epub 2018 Dec 9.

Rajaie Cardiovascular Medical & Research Center, Tehran, Iran.

Residual fibrous structures, referred as "ghosts", are occasionally encountered following lead extraction. Though typically detected in patients with cardiac device infections, their prognostic and therapeutic implications remain speculative. We describe a 62-year-old gentleman with history of sick sinus syndrome who presented atrial fibrillation with rapid ventricular response. Read More

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December 2018

The 3D Cancer Nucleus.

Authors:
Sabine Mai

Genes Chromosomes Cancer 2018 Dec 9. Epub 2018 Dec 9.

Cell Biology, Research Institute for Oncology and Hematology, CancerCare Manitoba, The University of Manitoba, Winnipeg, Canada.

Research into the three-dimensional (3D) organization of the cancer cell genome started over 100 years ago. We follow an exciting avenue of research in this field, from Hansemann's early observations of aberrant mitoses and nuclei in cancer cells in the late 19 century to Boveri's theory of the cancer cell in the early 20 century, to current views of nuclear organization and its changes in cancer. Molecular and imaging methods go hand in hand with providing us with a better understanding of the spatial nature of the cancer cell genome. Read More

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December 2018
1 Read

The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2.

Am J Med Genet B Neuropsychiatr Genet 2018 Dec 7. Epub 2018 Dec 7.

University of Alabama at Birmingham, Birmingham, Alabama.

Mutations in the X-linked gene MECP2 are associated with a severe neurodevelopmental disorder, Rett syndrome (RTT), primarily in girls. It had been suspected that mutations in Methyl-CpG-binding protein 2 (MECP2) led to embryonic lethality in males, however such males have been reported. To enhance understanding of the phenotypic spectrum present in these individuals, we identified 30 males with MECP2 mutations in the RTT Natural History Study databases. Read More

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December 2018
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Unexpected bird-feather mite associations revealed by DNA metabarcoding uncovers a dynamic ecoevolutionary scenario.

Mol Ecol 2018 Dec 10. Epub 2018 Dec 10.

Department of Evolutionary Ecology, Estación Biológica de Doñana (EBD-CSIC), Avda. Americo Vespucio 26, Sevilla, 41092, Spain.

The high relevance of host-switching for the diversification of highly host-specific symbionts (i.e., those commonly inhabiting a single host species) demands a better understanding of host-switching dynamics at an ecological scale. Read More

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December 2018

ACT-R: A cognitive architecture for modeling cognition.

Wiley Interdiscip Rev Cogn Sci 2018 Dec 7:e1488. Epub 2018 Dec 7.

College of Information Sciences and Technology, Pennsylvania State University, University Park, Pennsylvania.

ACT-R is a hybrid cognitive architecture. It is comprised of a set of programmable information processing mechanisms that can be used to predict and explain human behavior including cognition and interaction with the environment. We start by reviewing its history, which shapes its current form, contrasts and relates it to other architectures, and helps readers to anticipate where it is going. Read More

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December 2018

Cutaneous adult xanthogranuloma with a small portion of BRAF mutated Langerhans cell histiocytosis populations: A case report and the review of published work.

J Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile or adult xanthogranuloma (AXG) and Rosai-Dorfman disease (RDD), are rare disorders characterized by the proliferation of cells derived from monocyte/macrophage lineages. A few cases of LCH coexisting with xanthogranuloma or RDD have been reported. The etiology of these diseases remains unclear. Read More

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December 2018

Distal radial access for coronary angiography and percutaneous coronary intervention: A state-of-the-art review.

Authors:
Thierry Corcos

Catheter Cardiovasc Interv 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardiology, American Hospital of Paris and Hôpital Foch, Suresnes, France.

Since its introduction by Lucien Campeau three decades ago, percutaneous radial artery approach at the forearm has been shown to provide advantages over the femoral approach and has become the standard approach for coronary angiography and intervention. Though infrequent, vascular complications still remain, mainly radial artery occlusion. Therefore, a more distal radial approach at the snuffbox or at the dorsum of hand has been suggested, initially by anethesiologists for perioperative patient monitoring, and more recently by Babunashvili et al. Read More

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December 2018

Handling missing dosing history in population pharmacokinetic modeling: an extension to MDM method.

CPT Pharmacometrics Syst Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Division of Clinical Pharmacology, Department of Pediatrics, School of Medicine, University of Utah, Salt Lake City, UT, 84108.

A major challenge in population pharmacokinetic (popPK) modeling is handling data with missing or potentially incorrect dosing records. Leaving such records untreated or 'commented out' will cause bias in parameter estimates. Several approaches were previously developed to address this challenge. Read More

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December 2018

Ethics codes and use of new and innovative drugs.

Br J Clin Pharmacol 2018 Dec 9. Epub 2018 Dec 9.

Department of Clinical Immunology, Medical University of Warsaw, Nowogrodzka Str. 59, 02-006, Warsaw, Poland.

Treatment with new and/or innovative drugs with uncertain safety and efficacy profile is associated with substantial ethical concerns. The main objective of this paper is to present guidance on the use of such drugs contained in: 1) major international codes and guidelines pertaining to medical ethics and biomedical research; 2) national codes of medical ethics and professional conduct of the US, Canada, Australia, New Zealand, the UK, Ireland, France and Germany. Out of the four international codes and guidelines analyzed, only the Declaration of Helsinki addresses the question of the use of unproven drugs. Read More

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December 2018

Family history of cancer and DNA damage response genes: Two sides of the same coin?

Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.

Department of Medical Oncology, University Hospital of Parma, Parma, Italy.

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December 2018

Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Institute for Refractory Cancer Research.

Hypermutagenesis refers to marked increase in the number of mutations due to continuous mutagenic process. Hypermutated tumors, have being found in several tumor types, are associated with inherited or acquired alterations in DNA repair pathways. Hypermutation has been observed in a subset of adult glioma patients as a direct result of temozolomide(TMZ)-induced mutagenesis. Read More

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December 2018

Measuring quantity and function of pneumococcal antibodies in immunoglobulin products.

Transfusion 2018 Dec;58 Suppl 3:3114-3120

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Background: Immunoglobulin replacement therapy is a cornerstone of the treatment of primary immunodeficiencies. Preparations used for replacement therapy are processed by purifying immunoglobulins from large pools of plasma, which were obtained from healthy donors. The constituent antibodies in these products depend on the immune history of the donor pool as well as manufacturing processes that differ among manufacturers. Read More

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December 2018
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[Neuroethics of body transplantation].

Authors:
J A Alvarez-Diaz

Rev Neurol 2018 Dec;67(12):505-512

Universidad Autonoma Metropolitana-Xochimilco, Mexico DF, Mexico.

Introduction: Recent contributions to the specialised literature address the topic of body transplantation, mostly produced by Sergio Canavero and a group of researchers from China. For several years they have been announcing that they will carry out the procedure, but it has still not been performed.

Aims: The aim of this study is to perform a neuroethical analysis of body transplantation, based on the methodology of Diego Gracia on ethics and bioethics and an analysis of facts, values and duties. Read More

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December 2018

Oral probiotics influence oral and respiratory tract infections in pediatric population: a randomized double-blinded placebo-controlled pilot study.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):8034-8041

Department of Clinical and Translational Medicine "Tor Vergata" University of Rome, Rome, Italy.

Objective: Acute oral and respiratory tract infections (RTIs) are highly present in the general population, and they represent one of the most impacting causes of morbidity and mortality every year. The aim of our study was to assess the clinical impact of oral probiotics on acute oral and respiratory tract infections affecting paediatric patients.

Patients And Methods: This is a randomized, double-blinded placebo-controlled clinical study, where probiotics have been compared with placebo in a double-blinded investigation. Read More

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November 2018

[Psychotic symptoms as a side-effect of omeprazole].

Tijdschr Psychiatr 2018 ;60(12):834-837

A 12-year-old girl with no psychiatric history developed psychotic symptoms, including formal thought disorder and delusional ideas after omeprazole was initiated. Given the co-occurrence of omeprazole initiation and the start of these symptoms, omeprazole was discontinued and replaced by ranitidine which led to immediate symptom reduction followed by complete remission. Although the proton pump inhibitor (ppi) omeprazole is considered safe and is commonly prescribed, it can cause rare major psychiatric side-effects. Read More

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January 2018
2 Reads

[Residents in supported housing and factors related to moving towards independent living].

Tijdschr Psychiatr 2018 ;60(12):817-826

Background: Few data are available on predictors for the transition of individuals with mental illness to more independent forms of housing.
AIM: To analyse which variables predict the transition of individuals with severe mental illness from supported housing within the Dutch community housing programs (CHP) to more independent ways of living.
METHOD: Data of 1569 participants were analysed using Cox regression analysis. Read More

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January 2018

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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December 2018

Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):749-756. Epub 2018 Dec 7.

Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Objective:  To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010.

Methods:  Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. Read More

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December 2018
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Too Many Biopsies Performed to Rule Out Hirschsprung's Disease: But It is Worth Doing Them.

Eur J Pediatr Surg 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Surgery, Noah's Ark Children's Hospital for Wales, Cardiff, United Kingdom.

Introduction:  The U.K. National Institute for Health and Clinical Excellence (NICE) specify the following indications for performing rectal biopsy to rule out Hirschsprung's disease (HSD): (1) passage of meconium > 48 hours; (2) constipation since first few weeks of life; (3) chronic abdominal distension with vomiting; (4) family history of HSD; and (5) faltering growth in addition to any other indication. Read More

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December 2018

Prevalence of Depression, Anxiety and PTSD in People with Dementia: a Systematic Review and Meta-Analysis.

Neuropsychol Rev 2018 Dec 7. Epub 2018 Dec 7.

School of Psychology, Faculty of Health & Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.

There appears to be a link between depression/anxiety/PTSD and dementia, although the evidence is incomplete and the reason is unclear. Mental illness may cause dementia or may be prodromal or comorbid with dementia, or dementia may trigger a relapse of symptoms in individuals with a history of mental illness. This study examined the link between depression/anxiety/PTSD and dementia by evaluating the prevalence of these disorders in people with dementia, relative to their healthy peers. Read More

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December 2018

Real-World Use of Talimogene Laherparepvec in German Patients with Stage IIIB to IVM1a Melanoma: A Retrospective Chart Review and Physician Survey.

Adv Ther 2018 Dec 7. Epub 2018 Dec 7.

Amgen Ltd, Uxbridge, UK.

Introduction: Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metastatic melanoma (stage IIIB-IVM1a) in the pivotal phase III OPTiM study. The objective was to characterize melanoma patients treated with talimogene laherparepvec in routine clinical practice in Germany.

Methods: A retrospective chart review was conducted in unresectable stage IIIB-IVM1a melanoma patients. Read More

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December 2018

Leveraging the variable natural history of ductal carcinoma in situ (DCIS) to select optimal therapy.

Breast Cancer Res Treat 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, Brooklyn Breast Cancer Program of Maimonides Medical Center, 745 64th Street, Brooklyn, NY, 11220, USA.

Purpose: Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive ductal carcinoma. The authors sought to discuss the evidence suggesting that not all DCIS will progress to invasive disease if left untreated.

Results: Four lines of evidence align to suggest that not all of this in-situ disease progresses to invasive cancer: its prevalence on screening mammography, studies of missed diagnoses, incidental findings in autopsy specimens, and large retrospective reviews of those treated with excision alone. Read More

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December 2018

Prognosis of autoimmune hemolytic anemia in critically ill patients.

Ann Hematol 2018 Dec 10. Epub 2018 Dec 10.

Medical Intensive Care Unit, Saint-Louis Teaching Hospital, AP-HP, Paris, France.

Patients with autoimmune hemolytic anemia (AIHA) may require intensive care unit (ICU) admission. In order to describe the characteristics of AIHA patients in ICU and identify prognosis factors, clinical and biological data from 44 patients admitted in one ICU between 2002 and 2015 were retrospectively analyzed. The main reasons for ICU admission were profound anemia without any organ failure in 19 patients (either for safer transfusion or continuous monitoring only). Read More

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December 2018

Studies in the Stypella vermiformis group (Auriculariales, Basidiomycota).

Antonie Van Leeuwenhoek 2018 Dec 8. Epub 2018 Dec 8.

Natural History Museum, University of Oslo, P.O. Box 1172, Blindern, 0318, Oslo, Norway.

Stypella vermiformis is a heterobasidiomycete producing minute gelatinous basidiocarps on rotten wood of conifers in the Northern Hemisphere. In the current literature, Stypella papillata, the genus type of Stypella (described from Brazil), is treated as a taxonomic synonym of S. vermiformis. Read More

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December 2018

Factors associated with post-relapse survival in patients with recurrent cervical cancer: the value of the inflammation-based Glasgow Prognostic Score.

Arch Gynecol Obstet 2018 Dec 10. Epub 2018 Dec 10.

Gynecologic Cancer Unit, Department of Gynecology and Gynecologic Oncology, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.

Purpose: The aim of the present study was to assess the value of the Glasgow Prognostic Score (GPS) as a prognostic tool for predicting post-relapse survival (PRS) in patients with recurrent cervical cancer.

Methods: We retrospectively evaluated the data of 116 patients with recurrent cervical cancer in whom serologic biomarkers had been assessed at the time of relapse. The GPS was calculated as follows: patients with elevated serum C-reactive protein levels and hypoalbuminemia were allocated a score of 2, and those with 1 or no abnormal value were allocated a score of 1 and 0, respectively. Read More

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December 2018

Looking into the shadow: the eugenics argument in debates on reproductive technologies and practices.

Authors:
Giulia Cavaliere

Monash Bioeth Rev 2018 Dec 7. Epub 2018 Dec 7.

Department of Global Health and Social Medicine, School of Global Affairs, King's College London, Room 3.12, Bush House (NE), 30, Aldwych, London, WC2B 4BG, UK.

Eugenics is often referred to in debates on the ethics of reproductive technologies and practices, in relation to the creation of moral boundaries between acceptable and unacceptable technologies, and acceptable and unacceptable uses of these technologies. Historians have argued that twentieth century eugenics cannot be reduced to a uniform set of practices, and that no simple lessons can be drawn from this complex history. Some authors stress the similarities between past eugenics and present reproductive technologies and practices (what I define throughout the paper as 'the continuity view') in order to condemn the latter. Read More

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December 2018

[Clinical picture and diagnosis of neurotrophic keratopathy].

Authors:
E M Messmer

Ophthalmologe 2018 Dec 7. Epub 2018 Dec 7.

Augenklinik, Ludwig-Maximilians-Universität München, Mathildenstr. 8, 80336, München, Deutschland.

Background: Neurotrophic keratopathy is characterized by corneal surface alterations, persistent corneal epithelial defects and/or corneal ulcerations associated with corneal sensory abnormalities. Due to the variable clinical picture neurotrophic keratopathy is often overlooked or diagnosed too late in the course of the disease.

Objective: Discussion of the clinical picture of neurotrophic keratopathy and recommendations for correct diagnosis. Read More

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December 2018

Range Expansion Theories Could Shed Light on the Spatial Structure of Intra-tumour Heterogeneity.

Bull Math Biol 2018 Dec 7. Epub 2018 Dec 7.

Interfaculty Bioinformatics Unit, University of Bern, 3012, Bern, Switzerland.

Many theoretical studies of range expansions focus on the dynamics of species' ranges or on causes and consequences of biological invasions. The similarities between biological range expansions and the dynamics of tumour growth have recently become more obvious, highlighting that tumours can be viewed as a population of abnormal cells expanding its range in the body of its host. Here, we discuss the potential of recent theoretical developments in the context of range expansions to shed light on intra-tumour heterogeneity, and to develop novel computational and statistical methods for studying the increasingly available genomic and phenotypic data from tumour cells. Read More

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December 2018

Preparing to migrate: expression of androgen signaling molecules and insulin-like growth factor-1 in skeletal muscles of Gambel's white-crowned sparrows.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurobiology Physiology Behavior, University of California, Davis, USA.

Migratory birds, including Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii), exhibit profound modifications of skeletal muscles prior to migration, notably hypertrophy of the pectoralis muscle required for powered flight. Muscle growth may be influenced by anabolic effects of androgens; however, prior to spring departure, circulating androgens are low in sparrows. A seasonal increase in local androgen signaling may occur within muscle to promote remodeling. Read More

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December 2018

Periodontal Ehlers-Danlos syndrome is associated with leukoencephalopathy.

Neurogenetics 2018 Dec 8. Epub 2018 Dec 8.

Department of Child Neurology and Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Here, we report brain white matter alterations in individuals clinically and genetically diagnosed with periodontal Ehlers-Danlos syndrome, a rare disease characterized by premature loss of teeth and connective tissue abnormalities. Eight individuals of two families clinically diagnosed with periodontal Ehlers-Danlos syndrome were included in the present study and underwent general physical, dental, and neurological examination. Whole exome sequencing was performed, and all patients included in the study underwent MRI of the brain. Read More

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December 2018
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