269 results match your criteria Histoplasmosis Thoracic


Emergent Management of a Tracheoinnominate Fistula in the Community Hospital Setting.

Cureus 2020 Jun 2;12(6):e8403. Epub 2020 Jun 2.

Heart, Vascular, Thoracic Institute, Cleveland Clinic, Cleveland, USA.

Tracheoinnominate fistula is a rare but highly lethal complication of tracheostomy. Early recognition and interventions are key to patient survival. A 63-year-old woman had undergone tracheostomy for respiratory failure secondary to disseminated histoplasmosis. Read More

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http://dx.doi.org/10.7759/cureus.8403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331894PMC

Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review.

Semin Respir Crit Care Med 2020 Aug 6;41(4):522-537. Epub 2020 Jul 6.

Indiana University, School of Medicine, Pulmonary Critical Care Medicine, Thoracic Transplantation Program, Indianapolis, Indiana.

In endemic areas, dimorphic fungal infections due to , and account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnosis of pulmonary histoplasmosis, blastomycosis, and coccidioidomycosis is often delayed and associated with antibiotics overuse. In addition to being highly endemic to certain regions of North America, dimorphic fungi have global significance due to established areas of endemicity in all six inhabited continents, an increasingly interconnected world of travelers and transported goods, and a changing epidemiology as a result of global heating and anthropomorphic land utilization. Read More

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http://dx.doi.org/10.1055/s-0040-1702194DOI Listing

Difficult to Diagnose: An Unusual Cause of Cavitary Lung Lesion.

Am J Case Rep 2020 May 25;21:e921274. Epub 2020 May 25.

Department of Pulmonary and Critical Care Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

BACKGROUND Cavitary lung lesions are commonly identified on thoracic imaging, but typically require further workup for definitive diagnosis. CASE REPORT Here, we present the case of a 40-year-old Middle Eastern male who presented with an unusual cause of cavitary lung lesion with associated pleural mass and pleural thickening. He underwent bronchoscopic biopsy and computer tomography (CT)-guided core needle biopsy, both of which were non-diagnostic. Read More

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http://dx.doi.org/10.12659/AJCR.921274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274497PMC

[Clinical and imaging features of acute histoplasmosis].

Zhonghua Yi Xue Za Zhi 2019 Dec;99(46):3603-3607

Chongqing Public Health Medical Treatment Center, Chongqing 400016, China.

To investigate the clinical and imaging characteristics of acute histoplasmosis. The clinical and imaging data of 10 patients with acute histoplasmosis were studied. Their clinical and imaging characteristics were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.46.002DOI Listing
December 2019

Granulomatous Inflammation Presenting as a Pulmonary Artery Mass.

Ann Thorac Surg 2020 05 26;109(5):e363-e365. Epub 2019 Sep 26.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.

Granulomatous fungal infections are common worldwide, and they can result in mediastinal lymphadenopathy. However, infectious pulmonary artery masses are rare and have only been associated with tuberculosis or mucormycosis. Here, we present a case of histoplasmosis resulting in a pulmonary artery mass, which was treated with debulking and reconstruction of pulmonary vasculature. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.08.039DOI Listing
May 2020
3 Reads

Sequential surprises; Non endemic mycoses revealing immunodeficiency.

Indian J Pathol Microbiol 2019 Jul-Sep;62(3):512-513

Department of General Medicine, M.E.S. Medical College, Perinthalmanna, Kerala, India.

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http://dx.doi.org/10.4103/IJPM.IJPM_721_17DOI Listing
December 2019

Diagnosis of Fungal Infections. A Systematic Review and Meta-Analysis Supporting American Thoracic Society Practice Guideline.

Ann Am Thorac Soc 2019 09;16(9):1179-1188

Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.

Prompt diagnosis of invasive fungal infections is important because of the associated morbidity and mortality; however, diagnosis is challenging because of the nonspecific symptoms and radiographic findings. To conduct a systematic review and meta-analysis of studies that evaluated the diagnostic accuracy of serum and bronchoalveolar lavage (BAL) galactomannan (GM) and serum or BAL polymerase chain reaction (PCR) in patients with suspected invasive aspergillosis (IA), β-d-glucan in critically ill patients at risk for candidiasis or candidemia, and serology testing and antigen detection in patients with endemic mycoses (histoplasmosis, blastomycosis, and coccidioidomycosis). Studies were selected and appraised by pairs of reviewers. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201811-766OCDOI Listing
September 2019
12 Reads

Many Faces of Thoracic Histoplasmosis-Pictorial Essay.

Can Assoc Radiol J 2019 Aug 16;70(3):273-281. Epub 2019 May 16.

University of Montreal, Department of Medical Imaging, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.

Histoplasmosis is primarily a pulmonary fungal infection with a vast array of radiological manifestations, which can mimic a number of thoracic diseases. This article reviews various presentations of histoplasmosis on chest imaging. Read More

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http://dx.doi.org/10.1016/j.carj.2018.12.006DOI Listing
August 2019
8 Reads
0.584 Impact Factor

Histoplasmosis among HIV-Infected Patients in Japan: a Case Report and Literature Review.

Jpn J Infect Dis 2019 Sep 26;72(5):330-333. Epub 2019 Apr 26.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases.

Histoplasmosis is occasionally encountered in non-endemic countries owing to more frequent international travel and migration, as well as an increase in the number of vulnerable hosts (e.g., patients with cellular immunodeficiencies). Read More

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http://dx.doi.org/10.7883/yoken.JJID.2018.354DOI Listing
September 2019
7 Reads

Multimodality Imaging of Focal and Diffuse Fibrosing Mediastinitis.

Radiographics 2019 May-Jun;39(3):651-667. Epub 2019 Apr 5.

From the Department of Radiology, Saint Luke's Hospital of Kansas City, University of Missouri in Kansas City, 4401 Wornall Rd, Kansas City, MO 64111 (S.H.G., J.R.B., M.L.R.d.C., S.M.J., J.J.B.); and Ameripath, Kansas City, Mo (P.M.).

Fibrosing mediastinitis is a rare benign but potentially life-threatening process that occurs because of proliferation of fibrotic tissue in the mediastinum. The focal subtype is more common and typically is associated with an abnormal immunologic response to infection. Affected patients are typically young at presentation, but a wide age range has been reported, without a predilection for either sex. Read More

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http://dx.doi.org/10.1148/rg.2019180143DOI Listing
March 2020
4 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 03 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
24 Reads

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2017.0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198837PMC
October 2018
50 Reads

Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report

Biomedica 2018 09 1;38(3):298-302. Epub 2018 Sep 1.

Departamento de Hemato-Patología, Fundación Valle del Lili, Cali, Colombia.

The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. Read More

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http://dx.doi.org/10.7705/biomedica.v38i3.3739DOI Listing
September 2018
29 Reads

Histoplamosis in an immunocompetent man returning from Brazil: A diagnostic challenge helped by 18 FDG PET CT.

Travel Med Infect Dis 2019 Jan - Feb;27:136-138. Epub 2018 Oct 6.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Marseille, France.

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http://dx.doi.org/10.1016/j.tmaid.2018.10.004DOI Listing
April 2019
1 Read

[A man with thoracic pain after visiting the tropics].

Ned Tijdschr Geneeskd 2018 08 30;162. Epub 2018 Aug 30.

Spaarne Gasthuis, locatie Haarlem Zuid, afd. Longgeneeskunde.

A 25-year-old man presented to the Emergency Department with thoracic pain and coughing after travelling through South America. Radiologic work-up revealed diffuse multifocal consolidations surrounded by a ground-glass halo and thoracic lymphadenopathy. A urine antigen test was positive for Histoplasma capsulatum, a fungus that is endemic in South America and which causes a severe pulmonary infection in 5% of the infected patients. Read More

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August 2018
10 Reads

Pediatric Histoplasmosis in an Area of Endemicity: A Contemporary Analysis.

J Pediatric Infect Dis Soc 2019 Nov;8(5):400-407

Division of Infectious Diseases and Host Defense Program.

Background: Data on pediatric histoplasmosis have been limited to those from outbreak and case reports. We sought to evaluate the contemporary clinical manifestations, laboratory findings, and outcomes in children with histoplasmosis living in an area of endemicity.

Methods: This study was a single-center retrospective review of proven and probable cases of histoplasmosis in children aged 0 to 18 years between April 2008 and April 2014. Read More

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http://dx.doi.org/10.1093/jpids/piy073DOI Listing
November 2019
34 Reads

Detection of (1,3)-β-d-Glucan in Cerebrospinal Fluid in Histoplasma Meningitis.

J Clin Microbiol 2018 10 25;56(10). Epub 2018 Sep 25.

Division of Pulmonary and Critical Care Medicine, Thoracic Transplantation Program, Indiana University-School of Medicine, Indianapolis, Indiana, USA.

The diagnosis of central nervous system (CNS) histoplasmosis is often difficult. Although cerebrospinal fluid (CSF) (1,3)-β-d-glucan (BDG) is available as a biological marker for the diagnosis of fungal meningitis, there are limited data on its use for the diagnosis of meningitis. We evaluated CSF BDG detection, using the Fungitell assay, in patients with CNS histoplasmosis and controls. Read More

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http://dx.doi.org/10.1128/JCM.00663-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156302PMC
October 2018
20 Reads

Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.

Respiration 2018;96(3):283-301. Epub 2018 Jun 28.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Read More

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https://www.karger.com/Article/FullText/489501
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http://dx.doi.org/10.1159/000489501DOI Listing
October 2019
37 Reads

Tuberculosis and Other Granulomatous Diseases of the Airway.

Thorac Surg Clin 2018 May;28(2):155-161

Laval University, 6364, Chemin Royal, Saint-Laurent-de-l'Île-d'Orléans, Quebec City, Québec G0A3Z0, Canada.

Granulomatous diseases of the airway are challenging lesions to diagnose and effectively manage not only because they are uncommon but also because they can occur in different forms, each with unique clinical and radiological characteristics. Most such lesions can be effectively managed conservatively with repeated airway dilatation, use of intraluminal stents, and specific antimicrobial treatment. The only exception is those lesions presenting with localized airway obstruction wherein surgical resection may be indicated and beneficial. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2018.01.004DOI Listing
May 2018
19 Reads

Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States.

Med Mycol 2018 Oct;56(7):896-899

Yale School of Medicine, Department of Internal Medicine, Section of Infectious Diseases, New Haven, Connecticut, USA.

We performed a retrospective analysis of histoplasmosis cases diagnosed at our institution in New Haven, Connecticut, from 2005 to 2015. Among 12 cases of active histoplasmosis, seven were immunosuppressed and five had human immunodeficiency virus (HIV). Eleven patients reported travel to potentially endemic areas at a median of 105 days prior to presentation; travel to the Caribbean was most common (n = 6). Read More

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http://academic.oup.com/mmy/advance-article/doi/10.1093/mmy/
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http://dx.doi.org/10.1093/mmy/myx120DOI Listing
October 2018
5 Reads

Pulmonary Histoplasmosis Identified by Video-Assisted Thoracic Surgery (VATS) Biopsy: a Case Report.

J Korean Med Sci 2018 Jan 8;33(2):e15. Epub 2018 Jan 8.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Histoplasmosis is a common endemic mycosis in North, Central, and South America, but Korea is not known as an endemic area. We treated an immunocompetent Korean patient who had histoplasmosis. A 65-year-old Korean man presented with multiple pulmonary clumps of tiny nodules in the both lungs. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2018.3
Publisher Site
http://dx.doi.org/10.3346/jkms.2018.33.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729656PMC
January 2018
18 Reads
1.253 Impact Factor

Fever after recent travel.

Authors:
Habib Rehman

Cleve Clin J Med 2017 Nov;84(11):840-846

Clinical Associate Professor, Department of Medicine, Regina Qu'Appelle Health Region, Regina, SK, Canada.

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http://dx.doi.org/10.3949/ccjm.84a.16046DOI Listing
November 2017
20 Reads

Clinical Perspectives in the Diagnosis and Management of Histoplasmosis.

Clin Chest Med 2017 09 17;38(3):403-415. Epub 2017 May 17.

Thoracic Transplantation Program, Department of Medicine, Methodist Professional Center-2, Indiana University Health Methodist Hospital, Indiana University, Suite 2000, 1801 North Senate Boulevard, Indianapolis, IN 46202, USA. Electronic address:

With increasing numbers of travelers and immunocompromised patients, histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, has become a disease of national extent. The clinical spectrum of histoplasmosis is very wide, in terms of disease cadence, onset, distribution, and severity. A multipronged approach is recommended for diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02725231173003
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http://dx.doi.org/10.1016/j.ccm.2017.04.004DOI Listing
September 2017
6 Reads

Histoplasmosis mimicking metastatic spinal tumour.

J Int Med Res 2017 Aug 12;45(4):1440-1446. Epub 2017 Jun 12.

1 Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Histoplasmosis is an infection caused by a fungus called Histoplasma. Diagnosis of histoplasmosis is based on the culture of biological samples and detection of fungus in tissues. Histoplasmosis can mimic malignant lesions. Read More

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http://dx.doi.org/10.1177/0300060517708530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625537PMC
August 2017
6 Reads

Laboratory Diagnostics for Histoplasmosis.

J Clin Microbiol 2017 06 8;55(6):1612-1620. Epub 2017 Mar 8.

Department of Medicine, Thoracic Transplantation Program, Indiana University, Indianapolis, Indiana, USA.

The diagnosis of histoplasmosis is based on a multifaceted approach that includes clinical, radiographic, and laboratory evidence of disease. The gold standards for laboratory diagnosis include demonstration of yeast on pathological examination of tissue and isolation of the mold in the culture of clinical specimens; however, antigen detection has provided a rapid, noninvasive, and highly sensitive method for diagnosis and is a useful marker of treatment response. Molecular methods with improved sensitivity on clinical specimens are being developed but are not yet ready for widespread clinical use. Read More

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http://jcm.asm.org/lookup/doi/10.1128/JCM.02430-16
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http://dx.doi.org/10.1128/JCM.02430-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442517PMC
June 2017
8 Reads

Bronchoesophageal Fistula Repair with Intercostal Muscle Flap Followed by Occlusion of Residual Diverticula with N-butyl Cyanoacrylate (NBCA) Glue: A Case Report.

J Clin Diagn Res 2016 Aug 1;10(8):PD03-4. Epub 2016 Aug 1.

PG Resident, Department of Radiology & Imaging, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences , Shillong, Meghalaya, India .

The incidence of bronchoesophageal fistula in presence of benign pathology of tracheal tree or oesophagus is rare. It is encountered in thoracic diseases like tuberculosis, syphilis or histoplasmosis due to erosion by infected lymph node or abscess to adjoining structures. The source of primary pathology has to be eliminated followed by appropriate steps of fistula tract closure is essential for optimal result. Read More

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http://dx.doi.org/10.7860/JCDR/2016/15789.8303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5028568PMC
August 2016
4 Reads

Primary Cutaneous Histoplasmosis in an Immunocompetent Host from a Nonendemic Area.

Indian J Dermatol 2016 Jul-Aug;61(4):467

Department of Pathology, Dr. Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.

A 32-year-old male presented to Dermatology outpatient Department with complaints of a single nonhealing ulcer on his right thigh. This lesion was there for the last 1΍ months. It had begun as a small nodule and increased up to the present size of 3 cm with an oozing and ulcerated surface and thickened everted margins. Read More

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http://www.e-ijd.org/text.asp?2016/61/4/467/185748
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http://dx.doi.org/10.4103/0019-5154.185748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966422PMC
August 2016
10 Reads

Thoracic lymphadenopathy in benign diseases: A state of the art review.

Respir Med 2016 Mar 1;112:10-7. Epub 2016 Feb 1.

Federal University of Health Sciences of Porto Alegre, Porto Alegre, Brazil. Electronic address:

Lymphadenopathy is a common radiological finding in many thoracic diseases and may be caused by a variety of infectious, inflammatory, and neoplastic conditions. This review aims to describe the patterns of mediastinal and hilar lymphadenopathy found in benign diseases in immunocompetent patients. Computed tomography is the method of choice for the evaluation of lymphadenopathy, as it is able to demonstrate increased size of individual nodes, abnormalities of the interface between the mediastinum and lung, invasion of surrounding fat, coalescence of adjacent nodes, obliteration of the mediastinal fat, and hypo- and hyperdensity in lymph nodes. Read More

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http://dx.doi.org/10.1016/j.rmed.2016.01.021DOI Listing
March 2016
87 Reads

Improved Diagnosis of Acute Pulmonary Histoplasmosis by Combining Antigen and Antibody Detection.

Clin Infect Dis 2016 Apr 20;62(7):896-902. Epub 2016 Jan 20.

MiraVista Diagnostics.

Background: Acute pulmonary histoplasmosis can be severe, especially following heavy inoculum exposure. Rapid diagnosis is critical and often possible by detection of antigen, but this test may be falsely negative in 17% of such cases. Antibody detection by enzyme immunoassay (EIA) may increase sensitivity and permit the measurement of immunoglobulin M (IgM) and immunoglobulin G (IgG) classes of antibodies separately. Read More

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https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/
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http://dx.doi.org/10.1093/cid/ciw007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787609PMC
April 2016
8 Reads

Cannulation of the Internal Thoracic Artery with a Central Venous Catheter.

Am J Respir Crit Care Med 2016 Mar;193(5):e9-11

1 Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, and.

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http://dx.doi.org/10.1164/rccm.201509-1748IMDOI Listing
March 2016
6 Reads

Fibrosing mediastinitis: a rare complication of histoplasmosis.

BMJ Case Rep 2015 Nov 4;2015. Epub 2015 Nov 4.

New York University School of Medicine, New York, New York, USA.

We report a case of a 29-year-old man who presented with intermittent haemoptysis for about 18 months. Previously, his symptoms had been diagnosed as musculoskeletal pain and later as pneumonia. CT found a venous infarct in the right lung in addition to extensive lymphadenopathy in the mediastinum and pulmonary hila, with associated calcifications almost completely occluding the superior vena cava and azygos vein. Read More

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http://casereports.bmj.com/content/2015/bcr-2015-212774.full
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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2015-21277
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http://dx.doi.org/10.1136/bcr-2015-212774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654015PMC
November 2015
9 Reads

Endobronchial Ultrasound-guided Transvascular Needle Aspiration: A Single-Center Experience.

J Bronchology Interv Pulmonol 2015 Oct;22(4):306-11

*Norton Thoracic Institute, St Joseph's Hospital and Medical Center, Phoenix, AZ †Department of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH.

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is well established for the staging and diagnosis of lung cancer and mediastinal lymphadenopathy. Central mediastinal vascular structures may preclude EBUS-TBNA access to lymph nodes in the aortopulmonary window and certain centrally located parenchymal lesions. Thus, a transvascular approach is necessitated. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000227DOI Listing
October 2015
45 Reads

Evaluation of two new enzyme immunoassay reagents for diagnosis of histoplasmosis in a cohort of clinically characterized patients.

Med Mycol 2015 Nov 2;53(8):868-73. Epub 2015 Sep 2.

Thoracic Transplantation Program, Indiana University Health, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN

The performance characteristics of the recently available analyte-specific reagent based enzyme immunoassay (ASR-EIA) and in vitro diagnostic (IVD) kit for urine Histoplasma antigen detection were evaluated in a cohort of 50 clinically characterized patients with histoplasmosis and 50 control patients. Overall sensitivity and specificity of the ASR-EIA were significantly improved compared with those of the IVD kit (sensitivity 72% vs. 22%, P<. Read More

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http://dx.doi.org/10.1093/mmy/myv062DOI Listing
November 2015
19 Reads

Pulmonary hypertension due to fibrosing mediastinitis treated successfully with stenting of pulmonary vein stenoses.

Can J Cardiol 2015 Apr 24;31(4):548.e5-7. Epub 2014 Dec 24.

Divisions of Cardiology and Nursing, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:

We describe a patient with fibrosing mediastinitis after childhood histoplasmosis who presented with severe pulmonary hypertension secondary to pulmonary vein stenoses. Stenting of 2 stenosed pulmonary veins via a transseptal approach resulted in an immediate decrease in systolic pulmonary artery pressure from 90 to 68 mm Hg and improvement in dyspnea and cardiac index, which was sustained at 6 months. This case highlights the importance of routinely assessing the pulmonary veins during workup for pulmonary hypertension. Read More

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http://dx.doi.org/10.1016/j.cjca.2014.12.025DOI Listing
April 2015
24 Reads

[The clinical-radiologic-pathologic features of imported pulmonary histoplasmosis].

Zhonghua Jie He He Hu Xi Za Zhi 2015 Jan;38(1):23-8

Email:

Objective: To describe the clinical features and treatment of imported pulmonary histoplasmosis and therefore to improve the recognition and differential diagnosis of this disease.

Methods: The clinical data of 3 patients with imported pulmonary histoplasmosis in our hospital were collected and analyzed. Literatures published since 1989 were retrieved with 'pulmonary histoplasmosis' from PubMed, China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP data, of which all the literatures about imported pulmonary histoplasmosis were reviewed. Read More

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January 2015
15 Reads

Disseminated histoplasmosis with mucocutaneous immune reconstitution inflammatory syndrome in an HIV-infected patient.

AIDS Res Hum Retroviruses 2015 Mar;31(3):274-5

Infectious Disease Clinic, AOU IRCCS San Martino-IST, University of Genoa (DISSAL) , Genoa, Italy .

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http://www.liebertpub.com/doi/10.1089/aid.2014.0329
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http://dx.doi.org/10.1089/aid.2014.0329DOI Listing
March 2015
11 Reads

Histoplasmosis presenting with solitary pulmonary nodule: two cases mimicking pulmonary metastases.

Niger J Clin Pract 2015 Mar-Apr;18(2):304-6

Department of Thoracic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Pulmonary histoplasmosis is a granulomatous disease, whose diagnosis is not always easy, as it may simulate metastatic lesions due to similar radiographic findings. We herein report two cases of histoplasmosis with solitary pulmonary nodule in asymptomatic patients with histories of cancer surgeries, whose diagnoses were confirmed by postoperative pathological examinations. Doctors must pay attention to risk factors for immunosuppression such as the histories of chemotherapy, radiotherapy, or malignancy, which may increase chances of developing histoplasmosis. Read More

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http://dx.doi.org/10.4103/1119-3077.151075DOI Listing
August 2015
5 Reads

Low-positive histoplasma antigen results in the MVista assay should not be assumed to be false positive.

J Clin Microbiol 2014 Dec;52(12):4445

MiraVista Diagnostics and MiraBella Technologies, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1128/JCM.02514-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313342PMC
December 2014
71 Reads

Chronic bronchitis with fungal infection presenting with marked elevation of serum carbohydrate antigen 19-9: a case report.

Int J Clin Exp Pathol 2014 15;7(9):6307-12. Epub 2014 Aug 15.

Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China.

Carbohydrate antigen 19-9 (CA19-9) is the most frequently applied serum tumor marker for diagnosis of cancers in the digestive organs. However, some patients with benign diseases can have elevated serum levels of CA19-9 as well. The current study presents a 55-year-old female who was admitted to our hospital for further evaluation of a nodular cavity shadow in the right lower lobe and clarification of the cause of the marked elevation of serum CA19-9 levels. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203255PMC
July 2015
28 Reads

Thoracoscopic pneumonectomy in management of histoplasmosis and fibrosing mediastinitis.

Ann Thorac Surg 2014 Oct;98(4):e95-6

Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina.

Pulmonary histoplasmosis is generally a self-limited respiratory illness in endemic areas. Fibrosing mediastinitis is a severe chronic complication of pulmonary histoplasmosis in which pulmonary vessels and airways can be compressed with the potential for life-threatening implications. We present a 50-year-old male patient who presented with a total occlusion of the left pulmonary artery due to fibrosing mediastinitis. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2014.06.093DOI Listing
October 2014
5 Reads

Rupioid psoriasis and other skin diseases with rupioid manifestations.

Cutis 2014 Sep;94(3):119-21

833 Chestnut St, Ste 740, Philadelphia, PA 19107, USA.

The term rupioid has been used to describe well-demarcated, cone-shaped plaques with thick, dark, lamellate, and adherent crusts on the skin that somewhat resemble oyster or limpet shells. We present a case of rupioid psoriasis that was treated with methotrexate, topical steroids, and intralesional steroid injections. Rupioid manifestations have been clinically observed in a variety of disease settings, including rupioid psoriasis, reactive arthritis, disseminated histoplasmosis, keratotic scabies, secondary syphilis, and photosensitive skin lesions in association with aminoaciduria. Read More

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September 2014
21 Reads

[Fever and dyspnea in a Panamanian woman with a bleeding ulcer].

Presse Med 2014 Nov 26;43(11):1302-6. Epub 2014 Sep 26.

Complexo hospitalario universitario de Ourense, service de médecine interne-maladies infectieuses, 32005 Ourense, Espagne.

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http://dx.doi.org/10.1016/j.lpm.2014.05.014DOI Listing
November 2014
4 Reads

Late occurrence of Histoplasma duboisii cutaneous and pulmonary infection 18 years after exposure.

J Mycol Med 2014 Sep 23;24(3):229-33. Epub 2014 Aug 23.

Department of dermatology, Cochin hospital, AP-HP, université René-Descartes Paris V, Paris, France.

We report an imported case of Histoplasma capsulatum var. duboisii (H. duboisii) infection in a white French woman revealed by cutaneous lesions of the scalp, 18 years after her last stay in West and Central Africa. Read More

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http://dx.doi.org/10.1016/j.mycmed.2014.08.001DOI Listing
September 2014
12 Reads

Successful allograft root re-replacement for prosthetic valve endocarditis with improvement of renal function in a Jehovah's Witness patient.

J Thorac Cardiovasc Surg 2014 Oct 21;148(4):e199-200. Epub 2014 Jul 21.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2014.06.066DOI Listing
October 2014
22 Reads

Percutaneous recanalization of occluded brachiocephalic vein-superior vena cava connection after resection of mediastinal mass.

JACC Cardiovasc Interv 2014 Jul;7(7):e69-70

Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.jcin.2013.10.033DOI Listing
July 2014
10 Reads
1 Citation
7.345 Impact Factor

Calcified granulomatous disease: occupational associations and lack of familial aggregation.

Lung 2014 Dec 20;192(6):841-7. Epub 2014 Jul 20.

Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, USA,

Purpose: The acute host response to histoplasma capsulatum infection varies according to exposure and susceptibility. Late sequelae include calcifications in the lung, thoracic lymphatics, and spleen. Determinants of calcified granuloma formation are poorly studied and may differ from those affecting acute response. Read More

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http://link.springer.com/content/pdf/10.1007%2Fs00408-014-96
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http://link.springer.com/10.1007/s00408-014-9624-3
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http://dx.doi.org/10.1007/s00408-014-9624-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239180PMC
December 2014
32 Reads

Histoplasmosis in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS): multicenter study of outcomes and factors associated with relapse.

Medicine (Baltimore) 2014 Jan;93(1):11-8

From Division of Infectious Diseases (TM, RNG), Department of Internal Medicine, and Department of Public Health (TNC), University of Kentucky, Lexington, Kentucky; Division of Infectious Diseases (AMA), Department of Internal Medicine, Emory University, Atlanta, Georgia; Division of Infectious Diseases (AS), Department of Internal Medicine, University of Southern California, Los Angeles, California; Division of Infectious Diseases (AF), Department of Internal Medicine, University Medical Center of Southern Nevada, Las Vegas, Nevada; Department of Pulmonary and Critical Care Medicine, Thoracic Transplantation (CH), Indiana University Health, Indianapolis, Indiana; Division of Infectious Disease (JWB), Department of Internal Medicine, University of Alabama, Birmingham, Alabama; Departmentof Epidemiology (MJ), College of Public Health, University of Louisville, Louisville, Kentucky; Division of Infectious Disease (DMB), Department of Internal Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri; and MiraVista Diagnostics (MR, LJW), Indianapolis, Indiana.

Although discontinuation of suppressive antifungal therapy for acquired immunodeficiency syndrome (AIDS)-associated histoplasmosis is accepted for patients with immunologic recovery, there have been no published studies of this approach in clinical practice, and minimal characterization of individuals who relapse with this disease. We performed a multicenter retrospective cohort study to determine the outcome in AIDS patients following discontinuation of suppressive antifungal therapy for histoplasmosis. Ninety-seven patients were divided into a physician-discontinued suppressive therapy group (PD) (38 patients) and a physician-continued suppressive therapy group (PC) (59 patients). Read More

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http://dx.doi.org/10.1097/MD.0000000000000016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616326PMC
January 2014
20 Reads

A case in Europe of feline histoplasmosis apparently limited to the skin.

Vet Dermatol 2013 Dec 9;24(6):635-8, e158. Epub 2013 Oct 9.

Department of Dermatology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.

Background: Histoplasma capsulatum has a worldwide distribution, but reports in Europe remain rare. We present the second report of histoplasmosis in a cat in Europe and, to the best of our knowledge, the first case of feline histoplasmosis infection apparently limited to the skin.

Case Report: A 6-year-old male castrated outdoor cat was presented to the dermatology service with a history of skin lesions evolving over 1 month and consisting of multiple papules and nodules on the head and neck. Read More

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http://dx.doi.org/10.1111/vde.12077DOI Listing
December 2013
7 Reads

Co-infection of disseminated histoplasmosis and tuberculosis in an AIDS patient.

Autops Case Rep 2013 Jul-Sep;3(3):49-58. Epub 2013 Sep 30.

Anatomic Pathology Service, Hospital Universitário, Universidade de São Paulo, São Paulo/SP - Brazil.

Histoplasmosis is a fungal disease caused by the dimorphic fungus , recognized as an AIDS-defining illness since the Center for Disease Control's revision criteria in 1985. This infection is reported to be present in 5-20% of AIDS patients, and in 95% of the cases it is manifested in its disseminated form. Serum antibodies and/or antigen research can make diagnosis, but the demonstration of the agent by culture or histopathological examination remains the gold standard methods. Read More

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http://dx.doi.org/10.4322/acr.2013.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671895PMC
September 2013
2 Reads

Fungal infection mimicking pulmonary malignancy: clinical and radiological characteristics.

Lung 2013 Dec 17;191(6):655-62. Epub 2013 Sep 17.

Department of Imaging, AC Camargo Cancer Center, Rua Paulo Orozimbo, 726, Aclimação, São Paulo, SP, 01535-001, Brazil,

Objective: The purpose of this study was to evaluate the clinical and radiological features of patients with fungal infection mimicking thoracic malignancy and to establish a diagnostic approach for both clinicians and radiologists to avoid misdiagnosis.

Methods: In this retrospective study, we reviewed clinical and computed tomography (CT) findings from 27 patients who presented with suspicion of thoracic malignancy who were ultimately diagnosed with fungal disease.

Results: Patients' median age was 55. Read More

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http://link.springer.com/content/pdf/10.1007/s00408-013-9506
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http://link.springer.com/10.1007/s00408-013-9506-0
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http://dx.doi.org/10.1007/s00408-013-9506-0DOI Listing
December 2013
33 Reads