279 results match your criteria Histoplasmosis Thoracic

A Structured Program Maximizes Benefit of Lung Cancer Screening in an Area of Endemic Histoplasmosis.

Ann Thorac Surg 2022 Jul 30;114(1):241-247. Epub 2021 Jul 30.

Division of Thoracic Surgery, Department of Surgery, University of Cincinnati, College of Medicine, Cincinnati, Ohio. Electronic address:

Background: Lung cancer screening with low-dose computed tomography has demonstrated at least a 20% decrease in lung cancer-specific mortality, but it has the potential harm of unnecessary invasive procedures performed because of false-positive results. This study reports the outcomes of a structured multidisciplinary lung cancer screening program in an area of endemic histoplasmosis.

Methods: A retrospective review of patients undergoing lung cancer screening from December 2012 to March 2019 was conducted. Read More

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Case series of pediatric mediastinal granuloma related to histoplasmosis.

Pediatr Pulmonol 2021 09 20;56(9):2958-2965. Epub 2021 Jul 20.

Department of Pediatrics, Division of Allergy, Immunology and Pulmonary Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Introduction: Mediastinal granuloma (MG) is a postinfectious complication of histoplasmosis that remains a rare diagnosis in the pediatric literature. This case series presents a well phenotyped population to further characterize this disease process.

Methods: Thirty cases of MG in children under 21 years-of-age presenting over a 16-year period were retrospectively analyzed. Read More

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September 2021

Pulmonary histoplasmosis diagnosed in a Japanese woman after traveling to central and South America: A case report.

J Infect Chemother 2021 Nov 24;27(11):1658-1661. Epub 2021 Jun 24.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address:

Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, and Japan is considered a non-endemic area for histoplasmosis. Most patients diagnosed with histoplasmosis in the past usually have exposure to caves and bat guano with travel history to endemic areas. Therefore, travel history and risk activities should be comprehensively assessed when suspecting histoplasmosis because this important information may be overlooked. Read More

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November 2021

Mucocutaneous nasal histoplasmosis in an immunocompetent dog.

BMC Vet Res 2021 May 13;17(1):192. Epub 2021 May 13.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA.

Background: Histoplasma (H.) capsulatum is a dimorphic fungus, and infection is typically via inhalation of microconidia. After conversion to the yeast phase within the lung, the organism is subsequently disseminated to other tissues by macrophages. Read More

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Thoracic Endemic Fungi in the United States: Importance of Patient Location.

Radiographics 2021 Mar-Apr;41(2):380-398. Epub 2021 Feb 5.

From the Department of Clinical Radiology, University of Missouri-Columbia, 1 Hospital Dr, Columbia, MO 65212 (J.R.K., A.H.); Department of Radiology, University of Southern California, Los Angeles, Calif (L.F.B.); Departments of Diagnostic Radiology (C.F.) and Pathology (D.S.), Oregon Health Sciences & University, Portland, Ore; and Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kan (C.M.W.).

The digitization of radiographic studies along with high-speed transmission of images has formed the basis of teleradiology, which has become an integral component in the workflow of a contemporary radiology practice. It is with this advent and growing utilization of teleradiology that the significance of the source location of images has gained importance. Specifically, the importance of where the patient resides and what endemic fungi occur in that location cannot be underestimated. Read More

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November 2021

Spontaneous pneumothorax secondary to chronic cavitary pulmonary histoplasmosis.

J Community Hosp Intern Med Perspect 2020 Sep 3;10(5):483-487. Epub 2020 Sep 3.

Graduate Medical Education, Methodist Dallas Medical Center, Dallas, USA.

Histoplasma capsulatum is a dimorphic fungus that causes histoplasmosis. Chronic cavitary pulmonary histoplasmosis is rare, and typically manifests as apical cavitary lesions in patients with pre-existing chronic obstructive pulmonary disease. We report a case involving a 60-year-old female who presented to our facility with acute onset of dyspnea and dry cough. Read More

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September 2020

Clinical implications of pulmonary nodules detected in children.

Pediatr Pulmonol 2021 01 19;56(1):203-210. Epub 2020 Nov 19.

Division of Pediatric Respiratory Medicine, Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego, San Diego, California, USA.

Introduction: The management of children found to have pulmonary nodules is not well established. We determined how often diagnostic testing was pursued, the outcome of diagnostic testing, and how often pulmonary nodules were given a definitive diagnosis.

Method: A retrospective review of patients found to have pulmonary nodules. Read More

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January 2021

Mediastinal histoplasmosis with cardiac involvement in a cat.

J Vet Cardiol 2020 Oct 1;31:15-22. Epub 2020 Aug 1.

Department of Clinical Sciences, Veterinary Health Center, Kansas State University, 1800 Denison Ave, Manhattan, KS, 66506, USA.

Histoplasmosis is the second most common fungal infection reported among domestic felines in the United States. Dissemination of the organism after inoculation is common and affected organ systems include the respiratory tract, gastrointestinal tract, reticuloendothelial organs, skeletal system, integument, and ocular system. However, histoplasmosis presenting as a discrete granulomatous mass identified on echocardiogram has never been reported in the veterinary literature. Read More

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October 2020

Emergent Management of a Tracheoinnominate Fistula in the Community Hospital Setting.

Cureus 2020 Jun 2;12(6):e8403. Epub 2020 Jun 2.

Heart, Vascular, Thoracic Institute, Cleveland Clinic, Cleveland, USA.

Tracheoinnominate fistula is a rare but highly lethal complication of tracheostomy. Early recognition and interventions are key to patient survival. A 63-year-old woman had undergone tracheostomy for respiratory failure secondary to disseminated histoplasmosis. Read More

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Endemic Fungi Presenting as Community-Acquired Pneumonia: A Review.

Semin Respir Crit Care Med 2020 Aug 6;41(4):522-537. Epub 2020 Jul 6.

Indiana University, School of Medicine, Pulmonary Critical Care Medicine, Thoracic Transplantation Program, Indianapolis, Indiana.

In endemic areas, dimorphic fungal infections due to , and account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnosis of pulmonary histoplasmosis, blastomycosis, and coccidioidomycosis is often delayed and associated with antibiotics overuse. In addition to being highly endemic to certain regions of North America, dimorphic fungi have global significance due to established areas of endemicity in all six inhabited continents, an increasingly interconnected world of travelers and transported goods, and a changing epidemiology as a result of global heating and anthropomorphic land utilization. Read More

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Urine antigen-negative disseminated histoplasmosis mimicking post-transplant lymphoproliferative disorder.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

A 50-year-old woman with a history of kidney transplant presented with 2 days of abdominal pain after 6 months of recurrent streptococcal pharyngitis, fevers, weight loss and a new rash on her chest and back. Her examination was notable for a unilateral tonsillar exudate and 2-3 mm pink papules with a fine scale over her chest and back. CT of the abdomen and chest demonstrated several large lymph nodes, and laboratory investigation revealed new cytopenias and elevated transaminases. Read More

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Difficult to Diagnose: An Unusual Cause of Cavitary Lung Lesion.

Am J Case Rep 2020 May 25;21:e921274. Epub 2020 May 25.

Department of Pulmonary and Critical Care Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

BACKGROUND Cavitary lung lesions are commonly identified on thoracic imaging, but typically require further workup for definitive diagnosis. CASE REPORT Here, we present the case of a 40-year-old Middle Eastern male who presented with an unusual cause of cavitary lung lesion with associated pleural mass and pleural thickening. He underwent bronchoscopic biopsy and computer tomography (CT)-guided core needle biopsy, both of which were non-diagnostic. Read More

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[Clinical and imaging features of acute histoplasmosis].

Zhonghua Yi Xue Za Zhi 2019 Dec;99(46):3603-3607

Chongqing Public Health Medical Treatment Center, Chongqing 400016, China.

To investigate the clinical and imaging characteristics of acute histoplasmosis. The clinical and imaging data of 10 patients with acute histoplasmosis were studied. Their clinical and imaging characteristics were analyzed. Read More

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December 2019

Granulomatous Inflammation Presenting as a Pulmonary Artery Mass.

Ann Thorac Surg 2020 05 26;109(5):e363-e365. Epub 2019 Sep 26.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri.

Granulomatous fungal infections are common worldwide, and they can result in mediastinal lymphadenopathy. However, infectious pulmonary artery masses are rare and have only been associated with tuberculosis or mucormycosis. Here, we present a case of histoplasmosis resulting in a pulmonary artery mass, which was treated with debulking and reconstruction of pulmonary vasculature. Read More

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Sequential surprises; Non endemic mycoses revealing immunodeficiency.

Indian J Pathol Microbiol 2019 Jul-Sep;62(3):512-513

Department of General Medicine, M.E.S. Medical College, Perinthalmanna, Kerala, India.

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December 2019

Diagnosis of Fungal Infections. A Systematic Review and Meta-Analysis Supporting American Thoracic Society Practice Guideline.

Ann Am Thorac Soc 2019 09;16(9):1179-1188

Evidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.

Prompt diagnosis of invasive fungal infections is important because of the associated morbidity and mortality; however, diagnosis is challenging because of the nonspecific symptoms and radiographic findings. To conduct a systematic review and meta-analysis of studies that evaluated the diagnostic accuracy of serum and bronchoalveolar lavage (BAL) galactomannan (GM) and serum or BAL polymerase chain reaction (PCR) in patients with suspected invasive aspergillosis (IA), β-d-glucan in critically ill patients at risk for candidiasis or candidemia, and serology testing and antigen detection in patients with endemic mycoses (histoplasmosis, blastomycosis, and coccidioidomycosis). Studies were selected and appraised by pairs of reviewers. Read More

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September 2019

Many Faces of Thoracic Histoplasmosis-Pictorial Essay.

Can Assoc Radiol J 2019 Aug 16;70(3):273-281. Epub 2019 May 16.

University of Montreal, Department of Medical Imaging, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec, Canada.

Histoplasmosis is primarily a pulmonary fungal infection with a vast array of radiological manifestations, which can mimic a number of thoracic diseases. This article reviews various presentations of histoplasmosis on chest imaging. Read More

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Histoplasmosis among HIV-Infected Patients in Japan: a Case Report and Literature Review.

Jpn J Infect Dis 2019 Sep 26;72(5):330-333. Epub 2019 Apr 26.

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases.

Histoplasmosis is occasionally encountered in non-endemic countries owing to more frequent international travel and migration, as well as an increase in the number of vulnerable hosts (e.g., patients with cellular immunodeficiencies). Read More

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September 2019

Multimodality Imaging of Focal and Diffuse Fibrosing Mediastinitis.

Radiographics 2019 May-Jun;39(3):651-667. Epub 2019 Apr 5.

From the Department of Radiology, Saint Luke's Hospital of Kansas City, University of Missouri in Kansas City, 4401 Wornall Rd, Kansas City, MO 64111 (S.H.G., J.R.B., M.L.R.d.C., S.M.J., J.J.B.); and Ameripath, Kansas City, Mo (P.M.).

Fibrosing mediastinitis is a rare benign but potentially life-threatening process that occurs because of proliferation of fibrotic tissue in the mediastinum. The focal subtype is more common and typically is associated with an abnormal immunologic response to infection. Affected patients are typically young at presentation, but a wide age range has been reported, without a predilection for either sex. Read More

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Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 03 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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October 2018

Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report

Biomedica 2018 09 1;38(3):298-302. Epub 2018 Sep 1.

Departamento de Hemato-Patología, Fundación Valle del Lili, Cali, Colombia.

The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. Read More

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September 2018

Histoplamosis in an immunocompetent man returning from Brazil: A diagnostic challenge helped by 18 FDG PET CT.

Travel Med Infect Dis 2019 Jan - Feb;27:136-138. Epub 2018 Oct 6.

Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU-Méditerranée Infection, Marseille, France.

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[A man with thoracic pain after visiting the tropics].

Ned Tijdschr Geneeskd 2018 08 30;162. Epub 2018 Aug 30.

Spaarne Gasthuis, locatie Haarlem Zuid, afd. Longgeneeskunde.

A 25-year-old man presented to the Emergency Department with thoracic pain and coughing after travelling through South America. Radiologic work-up revealed diffuse multifocal consolidations surrounded by a ground-glass halo and thoracic lymphadenopathy. A urine antigen test was positive for Histoplasma capsulatum, a fungus that is endemic in South America and which causes a severe pulmonary infection in 5% of the infected patients. Read More

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Pediatric Histoplasmosis in an Area of Endemicity: A Contemporary Analysis.

J Pediatric Infect Dis Soc 2019 Nov;8(5):400-407

Division of Infectious Diseases and Host Defense Program.

Background: Data on pediatric histoplasmosis have been limited to those from outbreak and case reports. We sought to evaluate the contemporary clinical manifestations, laboratory findings, and outcomes in children with histoplasmosis living in an area of endemicity.

Methods: This study was a single-center retrospective review of proven and probable cases of histoplasmosis in children aged 0 to 18 years between April 2008 and April 2014. Read More

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November 2019

Detection of (1,3)-β-d-Glucan in Cerebrospinal Fluid in Histoplasma Meningitis.

J Clin Microbiol 2018 10 25;56(10). Epub 2018 Sep 25.

Division of Pulmonary and Critical Care Medicine, Thoracic Transplantation Program, Indiana University-School of Medicine, Indianapolis, Indiana, USA.

The diagnosis of central nervous system (CNS) histoplasmosis is often difficult. Although cerebrospinal fluid (CSF) (1,3)-β-d-glucan (BDG) is available as a biological marker for the diagnosis of fungal meningitis, there are limited data on its use for the diagnosis of meningitis. We evaluated CSF BDG detection, using the Fungitell assay, in patients with CNS histoplasmosis and controls. Read More

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October 2018

Diagnosis and Management of Systemic Endemic Mycoses Causing Pulmonary Disease.

Respiration 2018;96(3):283-301. Epub 2018 Jun 28.

Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany.

Systemic endemic mycoses cause high rates of morbidity and mortality in certain regions of the world and the real impact on global health is not well understood. Diagnosis and management remain challenging, especially in low-prevalence settings, where disease awareness is lacking. The main challenges include the variability of clinical presentation, the fastidious and slow-growing nature of the fungal pathogens, the paucity of diagnostic tests, and the lack of options and toxicity of antifungal drugs. Read More

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October 2019

Tuberculosis and Other Granulomatous Diseases of the Airway.

Thorac Surg Clin 2018 May;28(2):155-161

Laval University, 6364, Chemin Royal, Saint-Laurent-de-l'Île-d'Orléans, Quebec City, Québec G0A3Z0, Canada.

Granulomatous diseases of the airway are challenging lesions to diagnose and effectively manage not only because they are uncommon but also because they can occur in different forms, each with unique clinical and radiological characteristics. Most such lesions can be effectively managed conservatively with repeated airway dilatation, use of intraluminal stents, and specific antimicrobial treatment. The only exception is those lesions presenting with localized airway obstruction wherein surgical resection may be indicated and beneficial. Read More

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Clinical and epidemiological characterization of histoplasmosis cases in a nonendemic area, Connecticut, United States.

Med Mycol 2018 Oct;56(7):896-899

Yale School of Medicine, Department of Internal Medicine, Section of Infectious Diseases, New Haven, Connecticut, USA.

We performed a retrospective analysis of histoplasmosis cases diagnosed at our institution in New Haven, Connecticut, from 2005 to 2015. Among 12 cases of active histoplasmosis, seven were immunosuppressed and five had human immunodeficiency virus (HIV). Eleven patients reported travel to potentially endemic areas at a median of 105 days prior to presentation; travel to the Caribbean was most common (n = 6). Read More

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October 2018