6,983 results match your criteria Histoplasmosis Thoracic


An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: A proof of concept study.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.

Histoplasmosis is the most common endemic mycosis in the Americas. Currently, there is no laboratory test capable to detect subclinical or latent infections by Histoplasma capsulatum (Hc), which might develop as severe infections in immunocompromised individuals. For the first time to our knowledge, we explore the suitability of an interferon gamma release assay (IGRA) to detect latent Hc infection in asymptomatic individuals. Read More

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December 2018
1 Read

[Histoplasma capsulatum: an emerging agent in Chile?]

Rev Chilena Infectol 2018 ;35(3):309-311

Laboratorio Clínico, Hospital Lucio Córdova, Santiago, Chile.

In the last eleven months, we have diagnosed 9 cases of Histoplasmosis in our country. All patients affected were from endemic areas of South-America. Here, we wish to inform and prevent to all clinical laboratories from Chile about the presence of Histoplasma capsulatum in clinical samples. Read More

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January 2018

Histoplasmosis-induced ileal perforation in a patient with acquired immune deficiency syndrome: Case report.

JGH Open 2018 Aug 27;2(4):166-168. Epub 2018 Jun 27.

Gastroenterology Service, Clinica Angloamericana Lima Peru.

Intestinal involvement with disseminated histoplasmosis is common in some populations infected with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), especially in those who come from tropical zones. We report the case of a 29-year-old male patient, from a tropical zone, with HIV infection and a CD value less than 50 cells/mm, with a history of abdominal pain, fever, diarrhea, and weight loss. On presentation, he was pale, sweaty, and had abdominal rebound tenderness. Read More

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August 2018
1 Read

Oropharyngeal histoplasmosis in an HIV-negative patient.

Ear Nose Throat J 2018 Oct-Nov;97(10-11):E49-E50

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

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November 2018
1 Read

Primary cutaneous histoplasmosis.

Authors:
Blake Raggio

Ear Nose Throat J 2018 Oct-Nov;97(10-11):346-348

Department of Otolaryngology, Tulane University Medical Center, New Orleans, LA, USA.

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November 2018
1 Read

Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature.

BMC Infect Dis 2018 Nov 26;18(1):595. Epub 2018 Nov 26.

AcademicLaboratory of Parasitology and Mycology, Andrée Rosemon Hospital, 97306, Cayenne, French Guiana.

Background: American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infections. In immunocompromised individuals, progressive disseminated forms are frequent, leading to fatal outcome if untreated. Read More

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November 2018
1 Read

Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens.

PLoS Pathog 2018 Nov 19;14(11):e1007444. Epub 2018 Nov 19.

Department of Microbiology, Ohio State University, Columbus, OH, United States of America.

Copper toxicity and copper limitation can both be effective host defense mechanisms against pathogens. Tolerance of high copper by fungi makes toxicity as a defense mechanism largely ineffective against fungal pathogens. A forward genetic screen for Histoplasma capsulatum mutant yeasts unable to replicate within macrophages showed the Ctr3 copper transporter is required for intramacrophage proliferation. Read More

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November 2018
2 Reads

Host membrane glycosphingolipids and lipid microdomains facilitate Histoplasma capsulatum internalisation by macrophages.

Cell Microbiol 2018 Nov 14:e12976. Epub 2018 Nov 14.

Department of General Microbiology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Recognition and internalisation of intracellular pathogens by host cells is a multifactorial process, involving both stable and transient interactions. The plasticity of the host cell plasma membrane is fundamental in this infectious process. Here, the participation of macrophage lipid microdomains during adhesion and internalisation of the fungal pathogen Histoplasma capsulatum (Hc) was investigated. Read More

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November 2018
1 Read

Feline histoplasmosis presenting with bone and joint involvement: clinical and diagnostic findings in 25 cats.

J Feline Med Surg 2018 Nov 8:1098612X18806706. Epub 2018 Nov 8.

2 Veterinary Clinical Sciences, Oklahoma State University Center for Veterinary Sciences, Stillwater, OK, USA.

Objectives: The aim of this study was to describe clinical and diagnostic findings in cats with bone and joint disease associated with histoplasmosis.

Methods: Medical records from between 2011 and 2017 were reviewed. Inclusion criteria required: (1) diagnosis of histoplasmosis by cytology, histology, urine or serum Histoplasma antigen testing, or culture; and (2) lameness or joint effusion as a presenting complaint or physical examination finding. Read More

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November 2018
5 Reads

Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea.

Osong Public Health Res Perspect 2018 Oct;9(5):255-260

Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea.

Objectives: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. Read More

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October 2018
4 Reads

Diagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.

PLoS Negl Trop Dis 2018 Nov 5;12(11):e0006872. Epub 2018 Nov 5.

Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico City, Mexico.

Background: The Histoplasma urine antigen (HUAg) is the preferred method to diagnose progressive disseminated histoplasmosis (PDH) in HIV patients. In 2007, IMMY ALPHA Histoplasma EIA was approved for clinical for on-site use, and therefore useful for regions outside the United States. However, ALPHA-HUAg is considered inferior to the MVista-HUAg which is only available on referral. Read More

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November 2018
1 Read

MANAGEMENT OF NEOVASCULAR OCULAR HISTOPLASMOSIS: Past and Present.

Authors:
Kevin J Blinder

Retina 2018 Oct 31. Epub 2018 Oct 31.

The Retina Institute, St. Louis, Missouri; and Ophthalmology and Visual Sciences, Washington University, St. Louis, Missouri.

Purpose: To review the wide variety of treatment modalities available for choroidal neovascularization secondary to the presumed ocular histoplasmosis syndrome.

Methods: A literature search was performed to review the multitude of studies conducted to investigate the efficacy and safety of treatment modalities available for choroidal neovascularization secondary to the presumed ocular histoplasmosis syndrome.

Results: Each treatment modality is reviewed, with the studies summarized and presented to support or refute the method of treatment. Read More

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October 2018
1 Read

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

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October 2018
1 Read

[Histoplasma capsulatum electron microscopy isolated from a patient with disseminated histoplasmosis].

Rev Argent Microbiol 2018 Oct 27. Epub 2018 Oct 27.

Cátedra de Bacteriología y Micología, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina. Electronic address:

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October 2018
1 Read

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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October 2018
7 Reads

Recurrent Opportunistic Infections in a Thymectomised Patient with Myasthenia Gravis and Good's Syndrome.

Cureus 2018 Aug 10;10(8):e3130. Epub 2018 Aug 10.

Neurology, University of Missouri, Columbia, USA.

We report the case of a 65-year-old man with myasthenia gravis, who developed recurrent opportunistic infections following thymectomy and immunosuppressive therapy. Subsequent evaluation including immunological studies, flow cytometry, and bone marrow studies confirmed the diagnosis of Good's syndrome. The patient was successfully treated with intravenous immunoglobulin (IVIG) and has remained stable with a monthly IVIG regimen. Read More

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August 2018
1 Read

Accuracy of a novel histoplasmosis enzyme immunoassay to evaluate suspicious lung nodules.

Cancer Epidemiol Biomarkers Prev 2018 Oct 19. Epub 2018 Oct 19.

Department of Thoracic Surgery, Vanderbilt University Medical Center

Background: Granulomas caused by infectious lung diseases present as indeterminate pulmonary nodules (IPNs) on radiography. Newly available serum enzyme immunoassay (EIA) for histoplasmosis has not been studied for the evaluation of IPNs. We investigated serum biomarkers of histoplasmosis antibodies as an indication of benign disease in IPNs from a highly endemic region. Read More

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October 2018
4 Reads

Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: A systematic review of diagnostic accuracy studies.

PLoS Negl Trop Dis 2018 Oct 19;12(10):e0006802. Epub 2018 Oct 19.

CIC INSERM 1424, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Introduction: Disseminated histoplasmosis, a disease that often resembles and is mistaken for tuberculosis, is a major cause of death in patients with advanced HIV disease. Histoplasma antigen detection tests are an important addition to the diagnostic arsenal for patients with advanced HIV disease and should be considered for inclusion on the World Health Organization Essential Diagnostics List.

Objective: Our objective was to systematically review the literature to evaluate the diagnostic accuracy of Histoplasma antigen tests in the context of advanced HIV disease, with a focus on low- and middle-income countries. Read More

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October 2018
3 Reads

Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report

Biomedica 2018 09 1;38(3):298-302. Epub 2018 Sep 1.

Departamento de Hemato-Patología, Fundación Valle del Lili, Cali, Colombia.

The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. Read More

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September 2018
5 Reads

African Histoplasmosis in HIV-Negative Patients, Kimpese, Democratic Republic of the Congo.

Emerg Infect Dis 2018 Nov;24(11):2068-2070

We describe a case series of histoplasmosis caused by Histoplasma capsulatum var. duboisii during July 2011-January 2014 in Kimpese, Democratic Republic of the Congo. Cases were confirmed by histopathology, immunohistochemistry, and reverse transcription PCR. Read More

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November 2018
1 Read

Gastrointestinal histoplasmosis: a case series from a non-endemic region in North India.

Intest Res 2018 Oct 16. Epub 2018 Oct 16.

Department of Gastroenterology and Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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October 2018
2 Reads

Histoplasmosis following Systemic Immunomodulatory Therapy for Ocular Inflammation.

Am J Ophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Mayo Clinic Department of Ophthalmology, Rochester, MN. Electronic address:

Purpose: Histoplasmosis is a known complication of systemic immunosuppressive therapy, particularly among patients receiving tumor necrosis factor alpha (TNFα) inhibitors. There is limited data on the development of disseminated or pulmonary histoplasmosis among patients receiving systemic immunosuppressive medication for non-infectious ocular inflammation.

Design: Retrospective case series. Read More

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October 2018
1 Read
3.870 Impact Factor

Acute kidney injury and other factors associated with mortality in hiv-infected patients.

Rev Assoc Med Bras (1992) 2018 Jun;64(6):509-517

Department of Internal Medicine, School of Medicine, Federal University of Ceará.Fortaleza, Ceará, Brasil.

Objective: HIV-related mortality is still high, especially in developed countries. The aim of this study is to investigate factors associated to death in HIV-infected patients.

Methods: This is a cross-sectional study with all HIV adult patients admitted to a tertiary infectious diseases hospital in Fortaleza, Northeast Brazil, from January 2013 to December 2014. Read More

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June 2018
1 Read

Central nervous system histoplasmosis mimicking tentorium meningioma.

Rev Soc Bras Med Trop 2018 Sep-Oct;51(5):722

Departamento de Radiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

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September 2017
1 Read

Paracoccidioides spp. and Histoplasma capsulatum: current and new perspectives for diagnosis and treatment.

Curr Top Med Chem 2018 Oct 2. Epub 2018 Oct 2.

Department of Microbiology, Immunology and Parasitology, Federal University of Sao Paulo, Sao Paulo, SP. Brazil.

The thermally-dimorphic systemic fungal group includes several important human pathogens: Blastomyces dermatitidis, Coccidioides immitis and C. posadasii, Histoplasma capsulatum, Paracoccidioides brasiliensis, P. lutzii, and Talaromyces (Penicillium) marneffei. Read More

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October 2018
2 Reads

Histoplasmosis of the head and neck in the immunocompetent patient: Report of 2 cases.

Ear Nose Throat J 2018 Sep;97(9):E28-E31

Department of Otolaryngology-Head and Neck Surgery, Penn State Health, Milton S. Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA.

Histoplasmosis of the head and neck is rarely seen in immunocompetent patients. We report 2 new cases of histoplasmosis of the head and neck in immunocompetent patients, one an 80-year-old man and the other a 57-year-old man. The older man presented with oral cavity histoplasmosis; his symptoms included pain, dysphagia, and ulcerative lesions. Read More

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September 2018
1 Read

Non-tubercular caseous adenopathy in Senegal.

Med Sante Trop 2018 Aug;28(3):255-256

Service de dermatologie, hôpital Aristide LeDantec, 3001 Dakar, Sénégal.

The authors report the case of a 22-year-old man referred seven months after the onset of papulo-nodular skin lesions, lymphadenopathy, splenomegaly and hepatomegaly. Mycologic and histologic examination of skin lesions enabled the diagnosis of African histoplasmosis, by Histoplasma capsulatum var duboisii. The lymph nodes were caseous. Read More

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August 2018
2 Reads

Environmental and Wilderness-Related Risk Factors for Histoplasmosis: More Than Bats in Caves.

Authors:
James H Diaz

Wilderness Environ Med 2018 Dec 25;29(4):531-540. Epub 2018 Sep 25.

Environmental and Occupational Health Sciences, School of Public Health; and the School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA. Electronic address:

Introduction: Histoplasma capsulatum is a dimorphic fungus that causes histoplasmosis, a sporadic endemic mycosis with environmental, occupational, and wilderness exposure-related risk factors. The objectives of this review are to describe these risk factors, to alert clinicians to the different presenting manifestations of histoplasmosis, and to recommend effective management and prevention strategies.

Methods: Internet search engines were queried with keywords to select articles for review over the study period, 1950 to 2018. Read More

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December 2018
1 Read

Disseminated blastomycosis in a 36-year-old immunocompetent male from Chicago, IL.

Oxf Med Case Reports 2018 Oct 24;2018(10):omy071. Epub 2018 Sep 24.

Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.

Blastomycosis is a fungal infection caused by Blastomyces species. This infection is endemic to North America particularly states bordering the Mississippi, Ohio and St Lawrence Rivers, and the Great Lakes but also occurs worldwide. While the most common site of infection is the lung, it can also manifest in the bones, skin and central nervous system. Read More

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October 2018
1 Read

Multiplex polymerase chain reaction as an improved method for screening Histoplasma capsulatum mating types.

Mem Inst Oswaldo Cruz 2018 17;113(10):e180340. Epub 2018 Sep 17.

Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Setor de Imunodiagnóstico, Rio de Janeiro, RJ, Brasil.

Histoplasmosis is a systemic mycosis infection caused by Histoplasma capsulatum, a heterothallic ascomycete. The sexual reproduction of this fungus is regulated by the mating type (MAT1) locus that contains MAT1-1 and MAT1-2 idiomorphs, which were identified by uniplex polymerase chain reaction (PCR). This study aimed to optimise single-step multiplex PCR for the accurate detection of the distinct mating types of H. Read More

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October 2018
1 Read

Mapping Histoplasma capsulatum Exposure, United States.

Emerg Infect Dis 2018 Oct;24(10):1835-1839

Maps of Histoplasma capsulatum infection prevalence were created 50 years ago; since then, the environment, climate, and anthropogenic land use have changed drastically. Recent outbreaks of acute disease in Montana and Nebraska, USA, suggest shifts in geographic distribution, necessitating updated prevalence maps. To create a weighted overlay geographic suitability model for Histoplasma, we used a geographic information system to combine satellite imagery integrating land cover use (70%), distance to water (20%), and soil pH (10%). Read More

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October 2018
1 Read

Outbreaks of histoplasmosis: The spores set sail.

Authors:
George S Deepe

PLoS Pathog 2018 Sep 13;14(9):e1007213. Epub 2018 Sep 13.

Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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September 2018
1 Read

A Case of Isolated Gastrointestinal Histoplasmosis.

Cureus 2018 Jul 9;10(7):e2951. Epub 2018 Jul 9.

Gastroenterology, NYU Langone Hospital, New York , USA.

Histoplasmosis is a self-limited and asymptomatic disease in immunocompetent individuals. Patients with untreated human immunodeficiency virus (HIV) or immune suppression due to medications such as corticosteroids can present with disseminated and life-threatening infections. We present a case of a 60-year-old female that presented with recurrent diarrhea that was found to have isolated gastrointestinal (GI) histoplasmosis. Read More

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July 2018
1 Read

Characteristics of Invasive Fungal Infections among HIV Individuals from an Indigenous Origin in Mexico.

J Fungi (Basel) 2018 Sep 9;4(3). Epub 2018 Sep 9.

Medical Research Centre for Medical Mycology, Wellcome Trust Strategic Award, Institute of Medical Science, University of Aberdeen, King's College, Aberdeen AB24 3FX, UK.

In individuals with HIV/AIDS, 47% of the deaths are attributed to invasive fungal infections (IFIs), despite antiretroviral (ARV) therapy. This is a retrospective study carried out in the Hospital Regional de Alta Especialidad Oaxaca (HRAEO), southwest Mexico, where IFIs that occurred during 2016⁻2017 are described. A total of 55 individuals were included. Read More

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September 2018
3 Reads

Corrigendum to 'Cave Diving for a Diagnosis: Disseminated Histoplasmosis in the Immunocompromised' [IDCases 12 (2018) 92-94].

IDCases 2018 19;12:173. Epub 2018 Jun 19.

University of South Florida, Department of Infectious Disease.

[This corrects the article DOI: 10.1016/j.idcr. Read More

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June 2018
2 Reads

Primary adrenal insufficiency due to bilateral infiltrative disease.

Endocrine 2018 Dec 3;62(3):721-728. Epub 2018 Sep 3.

Division of Endocrinology, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.

Purpose: Evidence on clinical presentation, evaluation, and management of patients with primary adrenal insufficiency (PAI) due to bilateral adrenal infiltrative disease is scarce. Our objective was to review the clinical presentation, biochemical work-up, imaging findings, and management of patients with PAI due to infiltrative adrenal disease in order to determine the best diagnostic and management approach.

Methods: Retrospective study of patients with PAI due to bilateral infiltrative adrenal disease referred for adrenal biopsy during 2000-2014 at Mayo Clinic, Rochester, Minnesota. Read More

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December 2018
8 Reads

Immunohistochemical Cross-Reactivity Between Paracoccidioides sp. from Dolphins and Histoplasma capsulatum.

Mycopathologia 2018 Oct 30;183(5):793-803. Epub 2018 Aug 30.

Ryukyu Animal Medical Center, Yone 5-27, Tomigusuku, Okinawa, 901-0224, Japan.

Paracoccidioidomycosis ceti is a cutaneous disease of cetaceans caused by uncultivated Paracoccidioides brasiliensis or Paracoccidioides spp. Serological cross-reactions between paracoccidioidomycosis ceti and paracoccidioidomycosis, paracoccidioidomycosis and histoplasmosis, and paracoccidioidomycosis and coccidioidomycosis have been reported before. The present study aimed to detect immunohistochemical cross-reaction between antibodies to Paracoccidioides sp. Read More

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October 2018
2 Reads

A rare case of disseminated histoplasmosis in a patient with Crohn's disease on immunosuppressive treatment.

Indian J Gastroenterol 2018 Sep;37(5):472-474

Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.

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September 2018
1 Read

Successful endobronchial treatment of a non-healing tracheoesophageal fistula from a previous histoplasmosis capsulatum infection using decellularized porcine urinary bladder matrix.

J Surg Case Rep 2018 Aug 13;2018(8):rjy187. Epub 2018 Aug 13.

Inova Fairfax Hospital, Inova Heart and Vascular Institute, Inova Fairfax Hospital, Falls Church, VA.

Tracheoesophageal fistulas (TEF) are pathologic communications between the esophagus and the trachea or bronchi. The development of a TEF can result from malignant or benign etiologies. A common approach for the treatment of TEFs is the placement of endobronchial and esophageal stents to facilitate healing of the communication. Read More

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August 2018
3 Reads

Burden of HIV-associated histoplasmosis compared with tuberculosis in Latin America: a modelling study.

Lancet Infect Dis 2018 Oct 23;18(10):1150-1159. Epub 2018 Aug 23.

Centre d'Investigation Clinique 1424 Antilles-Guyane, Inserm, Centre Hospitalier de Cayenne, Cayenne, France; Equipe EA3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne, France.

Background: Fungal infections remain a major contributor to the opportunistic infections that affect people living with HIV. Among them, histoplasmosis is considered neglected, often being misdiagnosed as tuberculosis, and is responsible for numerous deaths in Latin America. The objective of this study was to estimate the burden of HIV-associated histoplasmosis compared with tuberculosis in Latin American countries. Read More

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October 2018
10 Reads

Histoplasmosis dethrones tuberculosis in Latin America.

Lancet Infect Dis 2018 Oct 23;18(10):1058-1060. Epub 2018 Aug 23.

Department of Public Health, Universidade Federal do Paraná, Curitiba, Brazil.

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October 2018
10 Reads

Endemic Mycoses in Solid Organ Transplant Recipients.

Infect Dis Clin North Am 2018 09;32(3):667-685

Division of Infectious Diseases, University of North Carolina, CB 7030, 130 Mason Farm Road, Chapel Hill, NC 27599, USA. Electronic address:

The endemic mycoses are a group of thermally dimorphic fungal pathogens occupying a specific geographic range. In North America, the chief endemic mycoses are histoplasmosis, coccidioidomycosis, and blastomycosis. Endemic fungi can cause serious infections in solid organ transplant recipients from primary infection, reactivation of latent disease, or donor-derived infection. Read More

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September 2018
3 Reads

Predictive factors for disseminated histoplasmosis in AIDS patients with fever admitted to a reference hospital in Brazil.

Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):479-484

Departamento de Saúde Comunitária, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

Introduction: In many settings, the lack of sensitive biomarkers of disseminated histoplasmosis (DH) leads to a clinical reliance on older diagnostic methods and delayed treatment initiation. The early recognition of DH is critical for survival, especially in patients with human immunodeficiency virus (HIV). This study aimed to identify clinical and laboratory findings associated with the definitive diagnosis of DH in low-income HIV patients in endemic areas. Read More

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September 2018
2 Reads

Anti-serum validation for use in immunohistochemistry for Trypanosoma cruzi detection.

Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):467-474

Departamento de Anatomia Patológica, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: The detection of Trypanosoma cruzi in tissue samples is important in many situations, such as testing of the reactivation of the infection. The detection of T. cruzi nests in endomyocardial biopsies (EMB) may be useful to evaluate graft rejection. Read More

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September 2018
2 Reads

Pediatric Histoplasmosis in an Area of Endemicity: A Contemporary Analysis.

J Pediatric Infect Dis Soc 2018 Aug 14. Epub 2018 Aug 14.

Division of Infectious Diseases and Host Defense Program.

Background: Data on pediatric histoplasmosis have been limited to those from outbreak and case reports. We sought to evaluate the contemporary clinical manifestations, laboratory findings, and outcomes in children with histoplasmosis living in an area of endemicity.

Methods: This study was a single-center retrospective review of proven and probable cases of histoplasmosis in children aged 0 to 18 years between April 2008 and April 2014. Read More

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August 2018
9 Reads

Treatment of disseminated histoplasmosis in advanced HIV using itraconazole with increased bioavailability.

Int J STD AIDS 2018 Aug 16:956462418788129. Epub 2018 Aug 16.

1 Department of Infectious Diseases, Alfred Health, Melbourne, Australia.

Disseminated histoplasmosis (DH), an endemic mycosis caused by the dimorphic fungus Histoplasma capsulatum, is a life-threatening infection in immunocompromised hosts. A patient with newly-diagnosed human immunodeficiency virus (HIV) infection presented with a violaceous, raised, indurated, pruritic rash over the face, arms and trunk on a background of significant weight loss, fevers with sweats, diarrhoea and worsening shortness of breath. His CD4+ T cell count was 14 cells/µl (12%). Read More

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August 2018
2 Reads

Angioinvasive Fungal Infections Impacting the Skin: Background, Epidemiology, and Clinical Presentation (Part 1).

J Am Acad Dermatol 2018 Aug 10. Epub 2018 Aug 10.

University of Iowa, Department of Dermatology and Pathology, 200 Hawkins Drive, Iowa City, IA 52246. Electronic address:

Angioinvasive fungal infections cause significant morbidity and mortality due to their propensity to invade blood vessel walls, resulting in catastrophic tissue ischemia, infarct, and necrosis. While occasionally seen in immunocompetent hosts, opportunistic fungi are emerging in immunosuppressed hosts, including patients with hematologic malignancy, acquired immunodeficiency syndrome (AIDS), organ transplant, and poorly controlled diabetes mellitus. The widespread use of antifungal prophylaxis has led to an "arms race" of emerging fungal resistance patterns. Read More

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August 2018
15 Reads

Idiopathic CD4 lymphocytopenia presenting with progressive disseminated histoplasmosis.

Med J Armed Forces India 2018 Jul 22;74(3):280-283. Epub 2017 Mar 22.

Professor (Pathology), Government Medical College, Kota, Rajasthan, India.

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July 2018
4 Reads

Epidemiological aspects of travel-related systemic endemic mycoses: a GeoSentinel analysis, 1997-2017.

J Travel Med 2018 Aug;25(1)

Department of Global Health, Boston University School of Public Health, Boston, MA, USA.

Background: International travel has increased in the past few decades, placing more travellers at risk of acquiring systemic endemic mycoses. There are limited published data on systemic endemic mycoses among international travellers. We report epidemiological characteristics of non-migrant, international travellers who acquired systemic endemic mycoses during travel. Read More

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August 2018
9 Reads

Disseminated histoplasmosis in pediatric kidney transplant recipients-A report of six cases and review of the literature.

Pediatr Transplant 2018 11 3;22(7):e13274. Epub 2018 Aug 3.

Department of Pediatrics, Division of General Pediatrics, Le Bonheur Children's Hospital, University of Tennessee Health Sciences Center, Memphis, Tennessee.

Background: We report a case series of histoplasmosis in KTx patients in a children's hospital in an endemic area.

Methods: All KTx cases from January 1, 2002, to August 31, 2016, were reviewed to identify those with disseminated histoplasmosis.

Results: The attack rate of histoplasmosis among our KTx patients was 6. Read More

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November 2018
3 Reads