7,479 results match your criteria Histoplasmosis

Serious fungal disease incidence and prevalence in Indonesia.

Mycoses 2021 May 10. Epub 2021 May 10.

Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.

Background: Indonesia is a tropical country, warm and humid, with numerous environmental fungi. Data on fungal disease burden helps policy makers and clinicians.

Objectives: We have estimated the incidence and prevalence of serious fungal diseases. Read More

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Histoplasmosis of the Central Nervous System: A Case Series between 1990 and 2019 in French Guiana.

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

2CIC INSERM 1424, Centre Hospitalier de Cayenne, Cayenne, French Guiana.

Disseminated histoplasmosis is the most frequent acquired immunodeficiency syndrome-defining illness in French Guiana. Paradoxically, central nervous system (CNS) involvement has been scarcely described. We aimed to identify CNS histoplasmosis in our territory. Read More

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Emergomycosis, an Emerging Systemic Mycosis in Immunocompromised Patients: Current Trends and Future Prospects.

Front Med (Lausanne) 2021 23;8:670731. Epub 2021 Apr 23.

Department of Microbiology, All India Institute of Medical Sciences, Jodhpur, India.

Recently, the global emergence of emergomycosis, a systemic fungal infection caused by a novel dimorphic fungus species has been observed among immunocompromised individuals. Though initially classified under the genus , a taxonomic revision in 2017 based on DNA sequence analyses placed five -like fungi under a separate genus . These include , and . Read More

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Implementation of Rapid Diagnostics Assays for Detection of Histoplasmosis and Cryptococcosis in Central American People Living with HIV.

Mycoses 2021 May 9. Epub 2021 May 9.

Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.

Objectives: Histoplasmosis and cryptococcosis are important public health problems in people living with HIV (PLHIV) in Central America. Conventional laboratory assays, based on microscopy and culture, are not optimal for the diagnosis of either disease. However, antigen (Ag) assays are rapid and highly accurate for the diagnosis of these infections. Read More

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Combining urine antigen and blood polymerase chain reaction for the diagnosis of disseminated histoplasmosis in hospitalized patients with advanced HIV disease.

Med Mycol 2021 May 7. Epub 2021 May 7.

Laboratório de Biologia Molecular de Parasitas e Fungos, Instituto Adolfo Lutz, São Paulo 01246-000, Brazil.

Disseminated histoplasmosis (DH) is endemic in Latin America and the Caribbean where diagnostic tools are restricted. We carried-out a 1-year prospective cohort study at a referral hospital in São Paulo, Brazil. Participants had > or =18 years old, were hospitalized due to any indication and had CD4+ < 200 cells/µl. Read More

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Histoplasmosis in the Republic of Congo dominated by African histoplasmosis, Histoplasma capsulatum var. duboisii.

PLoS Negl Trop Dis 2021 May 6;15(5):e0009318. Epub 2021 May 6.

Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Paris, France.

The Republic of Congo (RoC) is one of the African countries with the most histoplasmosis cases reported. This review summarizes the current status regarding epidemiology, diagnostic tools, and treatment of histoplasmosis in the RoC. A computerized search was performed from online databases Medline, PubMed, HINARI, and Google Scholar to collect literature on histoplasmosis in the RoC. Read More

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Acute Pulmonary Histoplasmosis Following COVID-19: Novel Laboratorial Methods Aiding Diagnosis.

J Fungi (Basel) 2021 Apr 28;7(5). Epub 2021 Apr 28.

Evandro Chagas National Institute of Infectious Diseases, Fiocruz, Rio de Janeiro 21040-900, Brazil.

The acute form of histoplasmosis usually occurs after the exposition of more than one individual to a common environmental source harboring . Here, we present two cases of acute pulmonary histoplasmosis seen within two weeks at a reference center for infectious diseases at Rio de Janeiro, Brazil. The patients did not present a common epidemiologic history for histoplasmosis, however both presented COVID-19 before the onset of histoplasmosis symptoms. Read More

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Successful Use of Multidisciplinary Palliative Care in the Outpatient Treatment of Disseminated Histoplasmosis in an HIV Positive Child.

Children (Basel) 2021 Apr 2;8(4). Epub 2021 Apr 2.

Baylor College of Medicine International Pediatric AIDS Initiative at Texas Children's Hospital, Houston, TX 77030, USA.

Histoplasmosis is an uncommon opportunistic infection in human immunodeficiency virus (HIV) positive children. The most common form is primary disseminated histoplasmosis, characterized by persistent fever and failure to thrive. A 10-year-old HIV positive girl presented to the Baylor College of Medicine Children's Foundation-Tanzania Mbeya Center of Excellence (COE) with ulcerated skin lesions and a violaceous facial rash. Read More

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A Rapid Screening Program for Histoplasmosis, Tuberculosis, and Cryptococcosis Reduces Mortality in HIV Patients from Guatemala.

J Fungi (Basel) 2021 Apr 1;7(4). Epub 2021 Apr 1.

Global Action Fund for Fungal Infections, 1208 Geneva, Switzerland.

Opportunistic infections (OIs) and advanced HIV disease (AHD) contribute to HIV-related mortality. Here, we analyzed the situation of AHD and OIs in a cohort of newly diagnosed HIV patients from Guatemala. We included 2127 adult patients from 13 facilities across the country during 2017 to 2018. Read More

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Causes of hypercalcemia in renal transplant recipients: persistent hyperparathyroidism and others.

Braz J Med Biol Res 2021 26;54(6):e10558. Epub 2021 Apr 26.

Divisão de Nefrologia, Departamento de Clinica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Hypercalcemia is common in patients after kidney transplantation (KTx) and is associated with persistent hyperparathyroidism in the majority of cases. This retrospective, single-center study evaluated the prevalence of hypercalcemia after KTx. KTx recipients were evaluated for 7 years after receiving kidneys from living or deceased donors. Read More

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Atypical Presentation of Histoplasmosis in an Older Woman.

Actas Dermosifiliogr 2021 Apr 24. Epub 2021 Apr 24.

Cátedra de Dermatología Médico Quirúrgica "Dr. Miguel Martínez". Hospital de Clínicas, Montevideo, Uruguay.

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Histoplasmosis overlapping with HIV and tuberculosis in sub-Saharan Africa: challenges and research priorities.

Ther Adv Infect Dis 2021 Jan-Dec;8:20499361211008675. Epub 2021 Apr 9.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Gulu University, P.O. Box 166, Gulu, Uganda.

Histoplasmosis, tuberculosis and HIV are all highly prevalent in sub-Saharan Africa (SSA). Co-occurrence of two or more of these infections has been reported in several populations of patients, especially those with advanced HIV infection where these opportunistic infections contribute to a significant morbidity and mortality. With a high burden of pulmonary tuberculosis (PTB) secondary to HIV in SSA, histoplasmosis is commonly misdiagnosed as smear-negative PTB in HIV patients due to similar clinical and radiological presentations. Read More

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Long-Term Infectious Complications of Kidney Transplantation.

Clin J Am Soc Nephrol 2021 Apr 20. Epub 2021 Apr 20.

Division of Pediatric Infectious Diseases, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio

Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care-associated infections, whereas late infections, beyond 6-12 months, are community-acquired infections. Opportunistic infections most frequently present in the first 12 months post-transplant and can be modulated on prior exposures and use of prophylaxis. Read More

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Screening for acute disseminated histoplasmosis in HIV disease using urinary antigen detection enzyme immunoassay: A pilot study in Cameroon.

J Microbiol Methods 2021 Apr 17:106226. Epub 2021 Apr 17.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom; The Global Action Fund for Fungal Infections, Genève, Switzerland.

Acute disseminated histoplasmosis (ADH) is an AIDS-defining illness and reported in Cameroon, but there are few data about its incidence. Between June and August 2019, we conducted a descriptive cross-sectional study to screen for histoplasmosis in a population of adults with HIV infection, irrespective of their CD4 T-cell counts, using Histoplasma urine antigen detection enzyme immunoassay (EIA) and histoplasmin skin test. Of the 138 participants screened, 36 (26%) had detectable antigen in urine, using an OD cut off of 0. Read More

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Fatigue, weight loss, hypotension and electrolyte imbalance after a long-term stay in Thailand: A diagnostic challenge.

Travel Med Infect Dis 2021 May-Jun;41:102063. Epub 2021 May 8.

Department of Hematology, Oncology, Clinical Immunology, Rheumatology, Saarland University, Homburg, Germany. Electronic address:

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Histoplasmosis: An Unusual Cause of Adrenal Insufficiency.

AACE Clin Case Rep 2021 Jan-Feb;7(1):29-31. Epub 2020 Dec 28.

Department of Endocrinology, University of Connecticut School of Medicine, Farmington, Connecticut.

Objective: Adrenal insufficiency (AI), if not diagnosed in a timely manner, can lead to fatal outcomes. Here we describe an unusual case of AI secondary to disseminated histoplasmosis (DH) and the importance of being aware of the association of infections and AI.

Methods: A 56-year-old Hispanic man with untreated HIV infection presented for the evaluation of left upper jaw swelling and pain. Read More

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December 2020

Experience with Liposomal Amphotericin B in Outpatient Parenteral Antimicrobial Therapy (OPAT).

Antimicrob Agents Chemother 2021 Apr 12. Epub 2021 Apr 12.

Division of Infectious Diseases, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Background: Outpatient parenteral antimicrobial therapy (OPAT) is a safe, effective, and convenient treatment strategy for patients receiving intravenous antimicrobials in the outpatient setting; however, data is limited describing the use and safety of liposomal amphotericin B (L-AMB).

Methods: Records of patients receiving L-AMB OPAT between 1/1/2015 and 7/31/2018 were retrospectively reviewed. The primary objective was to describe the OPAT patient population discharged on L-AMB and evaluate factors associated with readmission and adverse events (AE). Read More

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Dermoscopic Features of Giant Molluscum Contagiosum in a Patient with Acquired Immunodeficiency Syndrome.

Acta Dermatovenerol Croat 2020 Dec;28(7):233-235

Martyna Sławińska MD, PhD, Department of Dermatology, Venereology and Allergology Medical University of Gdańsk, Smoluchowskiego 17 Street, 80-214 Gdańsk;

Giant molluscum contagiosum (MC) is a peculiar variant of the disease with the presence of multiple or single lesions larger than 5 mm. In contrast to typical molluscum contagiosum, dermoscopic features of giant lesions have been poorly described, and none of the reports included multiple giant lesions in an immunocompromised patient. We present a patient with acquired immunodeficiency syndrome diagnosed with multiple giant molluscum contagiosum along with the dermoscopic features of this entity. Read More

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December 2020

High prevalence and mortality due to Histoplasma capsulatum in the Brazilian Amazon: An autopsy study.

PLoS Negl Trop Dis 2021 Apr 5;15(4):e0009286. Epub 2021 Apr 5.

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Background: Histoplasmosis is acquired by inhalation of spores of the dimorphic fungus Histoplasma spp. Although this pathogen is distributed worldwide, it is more prevalent in the Americas. However, the real burden of histoplasmosis remains undefined in many endemic regions. Read More

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Fungal Infections of Oral Cavity: Diagnosis, Management, and Association with COVID-19.

SN Compr Clin Med 2021 Mar 27:1-12. Epub 2021 Mar 27.

Department of Oral Pathology, Meghna Institute of Dental Sciences, Nizamabad, Telangana India.

The frequency of fungal infections is increasing due to immunodeficiency viruses and immunosuppressive drugs. The most common fungal infection of the oral cavity is candidiasis. The existence of can be a part of normal commensal; hence, the isolation of in the absence of clinical symptoms should exclude candidiasis. Read More

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Histoplasmosis in an off-trail Hiker receiving ustekinumab: Implications for Preventive and diagnostic strategies for patients receiving anti-IL-12/23 therapy.

Med Mycol Case Rep 2021 Jun 13;32:43-46. Epub 2021 Mar 13.

Weill Cornell Medicine, Division of Infectious Diseases, 1305 York Ave, New York, NY, 10021, USA.

Ustekinumab, an IL-12/23 inhibitor, is an important agent in treatment of inflammatory bowel disease and psoriasis. Clinical trials have not demonstrated significantly increased infection risk with ustekinumab. We report a case of disseminated histoplasmosis in the setting of ustekinumab and methotrexate following a hike in the Catskill Mountains, a region not commonly associated with . Read More

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Central nervous system histoplasmosis in a European immunocompetent patient: A challenging diagnosis.

Rev Neurol (Paris) 2021 Mar 31. Epub 2021 Mar 31.

12ème centre médical des armées, 98ème antenne médicale, French Military Health Service, Saint-Asiter, France. Electronic address:

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Complex and Controversial Roles of Eicosanoids in Fungal Pathogenesis.

J Fungi (Basel) 2021 Mar 28;7(4). Epub 2021 Mar 28.

Laboratório de Bioquímica e Imunologia das Micoses, Departamento de Microbiologia e Parasitologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói 24210-130, RJ, Brazil.

The prevalence of fungal infections has increased in immunocompromised patients, leading to millions of deaths annually. Arachidonic acid (AA) metabolites, such as eicosanoids, play important roles in regulating innate and adaptative immune function, particularly since they can function as virulence factors enhancing fungal colonization and are produced by mammalian and lower eukaryotes, such as yeasts and other fungi (, and ). produces prostaglandins (PG), Leukotrienes (LT) and Resolvins (Rvs), whereas the first two have been well documented in sp. Read More

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Case Report: Incidental Finding of COVID-19 Infection after Positron Emission Tomography/CT Imaging in a Patient with a Diagnosis of Histoplasmosis and Recurring Fever.

Am J Trop Med Hyg 2021 Apr 2. Epub 2021 Apr 2.

1Department of Radiology, D'Or Institute for Research and Education, Botafogo, Rio de Janeiro, Brazil.

This is a case report of a 37-year-old woman evaluated with 18F-fludeoxyglucose (18F-FDG) positron emission computed tomography/CT with recurrent fever after treatment with itraconazole for 6 weeks for histoplasmosis. The examination demonstrated a decrease in the dimensions of the pulmonary opacities previously identified in the left lower lobe and attributed to histoplasmosis. In addition to these pulmonary opacities, increased FDG uptake was also observed in lymph nodes present in the cervical region, mediastinum, left lung hilum, and hepatic hilum. Read More

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HIV-Associated Disseminated Histoplasmosis and Rare Adrenal Involvement: Evidence of Absence or Absence of Evidence.

Front Cell Infect Microbiol 2021 15;11:619459. Epub 2021 Mar 15.

Département Formation Recherche (DFR) Santé, Université de Guyane, Cayenne, French Guiana.

Adrenal histoplasmosis and primary adrenal insufficiency are mostly described in immunocompetent patients. This particular tropism is attributed to the presence of cortisol within the adrenal gland, a privileged niche for growth. In French Guiana, disseminated histoplasmosis is the main opportunistic infection in HIV patients. Read More

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Comparison of Blood (1->3)-β-D-Glucan Levels in AIDS-Related Pneumocystis jirovecii Pneumonia and AIDS-Related Progressive Disseminated Histoplasmosis.

Clin Infect Dis 2021 Mar 31. Epub 2021 Mar 31.

Division of Infectious Diseases and Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

In this retrospective study, (1->3)-β-D-glucan (B-glucan) was an unreliable marker for AIDS-related Pneumocystis jirovecii pneumonia (PCP) because a high percentage of participants with progressive disseminated histoplasmosis and respiratory symptoms had a positive B-glucan result. Where histoplasmosis is common attributing B-glucan positivity to PCP without further testing risks misdiagnosis. Read More

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A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis.

Cureus 2021 Feb 23;13(2):e13517. Epub 2021 Feb 23.

Internal Medicine, Sanford Health, University of North Dakota School of Medicine, Fargo, USA.

Histoplasmosis is usually self-limiting in healthy individuals but often fatal in immunocompromised patients. It can mimic primary lung malignancy and liver metastasis, causing a delay in appropriate therapy. We report a case of a 58-year-old male, with a 20 pack-year smoking habit, who presented with a three-week history of persistent fevers and productive cough with night sweats. Read More

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February 2021

Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage.

Clin Ophthalmol 2021 18;15:1189-1192. Epub 2021 Mar 18.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Submacular hemorrhage (SMH) has been reported to be toxic to the retina based on animal studies. However, observational studies of patients with neovascular-related SMH and those treated with intravitreal anti-vascular growth factor (anti-VEGF) therapy have shown many favorable visual acuity outcomes. We report two cases of neovascular-related SMH with ten or more years of follow-up. Read More

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Prevalence of pulmonary mycoses in smear-negative patients with suspected tuberculosis in the Brazilian Amazon.

Rev Iberoam Micol 2021 Mar 25. Epub 2021 Mar 25.

Tropical Medicine Post-Graduate Program - Amazonas State University/Dr. Heitor Vieira Dourado Tropical Medicine Foundation, Manaus, Amazonas, Brazil; Leônidas and Maria Deane Institute [ILMD], Oswaldo Cruz Foundation (FIOCRUZ), Manaus, Amazonas, Brazil.

Background: Pulmonary mycoses resemble clinically and radiologically chronic pulmonary tuberculosis. Studies describing the prevalence, etiology and clinical features of pulmonary mycosis are of crucial importance in the Brazilian Amazon.

Aims: To estimate the frequency of pulmonary mycoses in smear-negative tuberculosis patients; to describe their demographic, epidemiological, and clinical characteristics; and to evaluate diagnostic methods. Read More

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Intracranial hemorrhage secondary to disseminated histoplasmosis in AIDS: an uncommon presentation.

Rev Soc Bras Med Trop 2021 22;54:e0830-2020. Epub 2021 Mar 22.

Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Radiologia, Campinas, SP, Brasil.

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