7,051 results match your criteria Histoplasmosis


Evaluation of the diagnostic potential of CD1a immunohistochemistry for visceral leishmaniasis.

Rev Inst Med Trop Sao Paulo 2019 Apr 18;61:e25. Epub 2019 Apr 18.

Universidade Federal do Ceará, Faculdade de Medicina, Departamento de Patologia e Medicina Legal, Fortaleza, Ceará, Brazil.

Visceral Leishmaniasis is a public health problem caused by protozoans of the genus Leishmania. K39 serological test is commonly used in the initial investigation, with high specificity, but variable sensitivity. Amastigotes can be identified by optical microscopy, however, the differential diagnosis with cellular debris or other intracellular parasites is necessary. Read More

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http://dx.doi.org/10.1590/S1678-9946201961025DOI Listing

of the femoral bone.

J Res Med Sci 2019 25;24:19. Epub 2019 Mar 25.

Department of Pathology, Lautech Teaching Hospital, Ogbomosho, Nigeria.

Histoplasmosis due to is an emerging AIDS-defining opportunistic infection in HIV positive seen predominantly on the African continent between the Tropics of Cancer and Capricorn. is an invasive fungal organism with tropism for lymph nodes, skin and bones. The infection occurs more in patients with a CD4 count <50/mm and is usually dissemnnated Histoplasmosis due to is an emerging AIDS-defining opportunistic infection in HIV positive seen predominantly on the African continent between the Tropics of Cancer and Capricorn. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_97_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450135PMC
March 2019
0.608 Impact Factor

Pauci-Immune Crescentic Glomerulonephritis due to Disseminated Histoplasmosis.

Kidney Int Rep 2019 Apr 9;4(4):629-632. Epub 2019 Jan 9.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451085PMC
April 2019
1 Read

Health Considerations for HIV-Infected International Travelers.

Curr Infect Dis Rep 2019 Apr 12;21(5):16. Epub 2019 Apr 12.

Harvard Medical School, Boston, MA, USA.

Purpose Of The Review: International travel continues to steadily increase, including leisure travel, travel to one's country of origin to visit friends and relatives, travel for service work, and business travel. Travelers with HIV may have an increased risk for travel-associated infections. The pre-travel medical consultation is an important means of assessing one's risk for travel-related health issues. Read More

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http://dx.doi.org/10.1007/s11908-019-0672-yDOI Listing
April 2019
6 Reads

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review.

Clin Rheumatol 2019 Apr 13. Epub 2019 Apr 13.

Departments of Medicine and Rheumatology, MetroHealth Medical Center, Cleveland, OH, USA.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. Read More

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http://dx.doi.org/10.1007/s10067-019-04548-8DOI Listing
April 2019
1 Read

Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment.

BMC Microbiol 2019 Apr 8;19(1):75. Epub 2019 Apr 8.

Institute for Microbiology, Virology and Hygiene, University Medicine Rostock, Schillingallee 70, 18057, Rostock, Germany.

Background: The potential of next-generation sequencing (NGS) for hypothesis-free pathogen diagnosis from (poly-)microbially contaminated, formalin-fixed, paraffin embedded tissue samples from patients with invasive fungal infections and amebiasis was investigated. Samples from patients with chromoblastomycosis (n = 3), coccidioidomycosis (n = 2), histoplasmosis (n = 4), histoplasmosis or cryptococcosis with poor histological discriminability (n = 1), mucormycosis (n = 2), mycetoma (n = 3), rhinosporidiosis (n = 2), and invasive Entamoeba histolytica infections (n = 6) were analyzed by NGS (each one Illumina v3 run per sample). To discriminate contamination from putative infections in NGS analysis, mean and standard deviation of the number of specific sequence fragments (paired reads) were determined and compared in all samples examined for the pathogens in question. Read More

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http://dx.doi.org/10.1186/s12866-019-1448-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454699PMC
April 2019
1 Read

Endemic fungal infections in solid organ transplant recipients-Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Mar 29:e13553. Epub 2019 Mar 29.

Department of Internal Medicine, University of Kansas School of Medicine Wichita, Wichita, Kansas.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention and management of blastomycosis, histoplasmosis, and coccidioidomycosis in the pre- and post-transplant period. Though each of these endemic fungal infections has unique epidemiology and clinical manifestations, they all share a predilection for primary pulmonary infection and may cause disseminated infection, particularly in immunocompromised hosts. Culture remains the gold standard for definitive diagnosis, but more rapid diagnosis may be achieved with direct visualization of organisms from clinical specimens and antigen-based enzyme immunoassay assays. Read More

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http://dx.doi.org/10.1111/ctr.13553DOI Listing
March 2019
1 Read

[Climate change and systemic fungal infections].

Authors:
Volker Rickerts

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Mar 28. Epub 2019 Mar 28.

FG 16, Erreger von Mykosen, Mykobakteriosen und Parasitosen, Konsiliarlabor für Kryptokokkose und seltene Systemmykosen, Robert Koch-Institut, Seestraße 10, 13353, Berlin, Deutschland.

Background: Climate change may cause profound and complex changes in the prevalence of infectious diseases. Obligate pathogenic fungi causing endemic mycoses and the agents of cryptococcosis are environmental pathogens adapted to environmental niches. They may be exposed to changing climatic conditions, which may change the epidemiology of human infections. Read More

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http://dx.doi.org/10.1007/s00103-019-02931-zDOI Listing
March 2019
1 Read

Incidence and trends in immune reconstitution inflammatory syndrome associated with Histoplasma capsulatum among people living with HIV: a 20-year case series and literature review.

Clin Infect Dis 2019 Mar 28. Epub 2019 Mar 28.

Equipe EA3593, Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, Cayenne, France.

Background: Histoplasmosis is among the main AIDS-defining conditions in endemic areas. Although histoplasmosis has a worldwide distribution, histoplasmosis-associated immune reconstitution inflammatory syndrome (IRIS) in people living with HIV (PLHIV) is rarely reported.This study aimed to describe the incidence and features of histoplasmosis-associated IRIS in a cohort of PLHIV. Read More

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http://dx.doi.org/10.1093/cid/ciz247DOI Listing
March 2019
1 Read

A case report of disseminated histoplasmosis and concurrent cryptococcal meningitis in a patient treated with ruxolitinib.

BMC Infect Dis 2019 Mar 27;19(1):287. Epub 2019 Mar 27.

Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093-0711, USA.

Background: Ruxolitinib is a highly potent janus kinase inhibitor that places its users at risk for various bacterial infections and viral reactivation. However new reports are also emerging that suggest greater immunosuppression and risk for fungal disease.

Case Presentation: We report the case of a 51 year-old veteran from Guam, treated with ruxolitinib for polycythemia vera, who developed disseminated histoplasmosis and concurrent cryptococcal meningitis. Read More

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http://dx.doi.org/10.1186/s12879-019-3922-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437885PMC
March 2019
1 Read

Disseminated pulmonary histoplasmosis in immunocompetent patients: a common epidemiological exposure.

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Department of Medicine - Pulmonary & Critical Care, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

We describe the initial presentation, diagnostic work-up and treatment of three adult immunocompetent men who presented within a short time frame of each other to an academic medical centre with acute respiratory distress syndrome. Their presentation was found to be secondary to a large inoculum of histoplasmosis from remodelling a building with bat droppings infestation. We discuss the pathophysiology of histoplasmosis and highlight the importance of exposure history in patients with acute respiratory failure and why patients with the occupational risk of exposure to fungal inoculum should wear protective respirator gear. Read More

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http://dx.doi.org/10.1136/bcr-2018-227994DOI Listing
March 2019
3 Reads

Diagnostic Dilemma of Disseminated Histoplasmosis Mimicking Hemophagocytosis Lymphohistiocytosis in Patient with Rheumatoid Arthritis on Anti-TNF Therapy: Case Report and Review of the Literature.

Case Rep Rheumatol 2019 12;2019:4169052. Epub 2019 Feb 12.

Assistant Professor, Division of Rheumatology, University of Kentucky, Lexington, USA.

Tumor necrosis factor inhibitors (TNFi) have become the cornerstone for the treatment of rheumatoid arthritis and other systemic autoimmune conditions. However, these biologic DMARDs can lead to various opportunistic infections such as viral infection, tuberculosis, and histoplasmosis. Furthermore, these biologics can also cause severe systemic inflammatory reactions known as hemophagocytosis lymphohistiocytosis (HLH) that can lead to multiorgan failure and high mortality. Read More

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https://www.hindawi.com/journals/crirh/2019/4169052/
Publisher Site
http://dx.doi.org/10.1155/2019/4169052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390234PMC
February 2019
4 Reads

Disseminated Histoplasmosis.

N Engl J Med 2019 Mar;380(11):e13

Centre Hospitalier Universitaire de Nice, Nice, France

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http://dx.doi.org/10.1056/NEJMicm1809792DOI Listing
March 2019
1 Read

Oral ulcerative lesions in a post-liver-transplantation patient.

Autops Case Rep 2019 Jan-Mar;9(1):e2018046. Epub 2019 Jan 14.

AC Camargo Cancer Center, Stomatology Department. São Paulo, SP, Brazil.

Oral involvement is rarely found in histoplasmosis, except in its disseminated form, which is mostly observed in the severely immunocompromised host. Herein, we presented the case of a 36-year-old female with a previous history of liver transplant, who was hospitalized due to fever, chills, night sweats, diarrhea, and painful oral lesions over the last 3 days. The oral examination revealed the presence of painful shallow ulcers lined by a pseudomembrane in the gingiva and the soft and hard palate. Read More

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http://dx.doi.org/10.4322/acr.2018.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394359PMC
January 2019
1 Read

Reactivation of latent and disseminated cytomegalovirus in a returning traveller with ulcerative colitis.

JMM Case Rep 2018 Dec 23;5(12):e005170. Epub 2018 Nov 23.

The Royal London Hospital, Whitechapel Road, Whitechapel, London E1 1BB, UK.

Introduction: We describe a case of progressive disseminated histoplasmosis (PDH) and disseminated cytomegalovirus (CMV) with development of haemophagocytic lymphohistiocytosis in a 62-year-old man of Bangladeshi origin living in the UK.

Case Presentation: The patient had a background of ulcerative colitis for which he took prednisolone and azathioprine. He presented with fever, lethargy, cough, weight loss and skin redness, and was initially treated for bacterial cellulitis and investigated for underlying malignancy. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412033PMC
December 2018
1 Read

Molecular detection of Histoplasma capsulatum indoors: A public health approach.

Rev Iberoam Micol 2019 Mar 9. Epub 2019 Mar 9.

Laboratory of Zoonoses and Vector-borne Diseases, Zoonoses Surveillance Division - Health Surveillance Coordination, São Paulo, SP, Brazil. Electronic address:

Background: Histoplasmosis, caused by the dimorphic fungus Histoplasma capsulatum, represents an important public health problem, especially in urban environments where bats and humans cohabit indoors.

Aims: To detect the presence of H. capsulatum indoors, using samples of bat droppings collected in roost sites inside houses. Read More

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http://dx.doi.org/10.1016/j.riam.2019.01.002DOI Listing
March 2019
1 Read

An immigrant with acquired immunodeficiency syndrome presenting with a rash: A case report.

SAGE Open Med Case Rep 2019 1;7:2050313X19829616. Epub 2019 Mar 1.

Section of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, Canada.

A 58-year-old woman from Zimbabwe, with a history of untreated human immunodeficiency virus, presented with leonine facies and a diffuse rash. The rash occurred in the context of a 1-year history of constitutional symptoms and cognitive decline. Laboratory investigations confirmed that her human immunodeficiency virus had progressed to acquired immunodeficiency syndrome. Read More

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http://dx.doi.org/10.1177/2050313X19829616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399754PMC
March 2019
1 Read

Isolated conjunctival histoplasmosis in an elderly patient: a rare but important scenario.

Can J Ophthalmol 2019 Feb 16;54(1):e15-e16. Epub 2018 May 16.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1016/j.jcjo.2018.04.003DOI Listing
February 2019

Progressive disseminated histoplasmosis with concomitant disseminated nontuberculous mycobacterial infection in a patient with AIDS from a nonendemic region (California).

BMC Pulm Med 2019 Feb 21;19(1):46. Epub 2019 Feb 21.

Department of Infectious Disease, Arrowhead Regional Medical Center, Colton, USA.

Background: Opportunistic infections, while well studied in the AIDS population, continue to have variable and surprising presentations. Here, we present a case of disseminated histoplasmosis with disseminated nontuberculous mycobacterial infection in a 50 year old man with long standing AIDS living in a non-endemic area.

Case Presentation: Patient presented with a constellation of symptoms, and imaging of the chest showed a pulmonary mass with cavitation, multiple nodules, and ground glass opacities. Read More

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http://dx.doi.org/10.1186/s12890-019-0808-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383272PMC
February 2019

Catheter based treatments for fibrosing mediastinitis.

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.

Fibrosing mediastinitis is a rare, often debilitating and potentially lethal disease characterized by an exuberant fibroinflammatory response within the mediastinum. Patients typically present with insidious symptoms related to compression of adjacent structures including the esophagus, heart, airways, and cardiac vessels. Fibrosing mediastinitis is most often triggered by Histoplasmosis infection; however, antifungal and anti-inflammatory therapies are largely ineffective. Read More

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http://dx.doi.org/10.1002/ccd.28152DOI Listing
February 2019
2 Reads

Mixed infection by Histoplasma capsulatum isolates with different mating types in Brazilian AIDS-patients.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e8. Epub 2019 Feb 14.

Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Micologia, Setor Imunodiagnóstico, Rio de Janeiro, Rio de Janeiro, Brazil.

Mixed infection by Histoplasma capsulatum isolates with different mating types, in AIDS-patients are described in this study. Morphological, mating type-specific PCR assay and multilocus sequencing type analysis of H. capsulatum isolates recovered from two Brazilian AIDS-patients were performed. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/S1678-9946201961008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376931PMC
February 2019
4 Reads

Acute Respiratory Distress Syndrome Secondary to Histoplasmosis-induced Hemophagocytic Lymphohistiocytosis.

Arch Bronconeumol 2019 Feb 15. Epub 2019 Feb 15.

Division of Pulmonary and Critical Care Medicine, Medstar Georgetown University Hospital, Washington, DC, United States.

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http://dx.doi.org/10.1016/j.arbres.2018.12.011DOI Listing
February 2019
2 Reads
1.816 Impact Factor

Pulmonary histoplasmoma: a disguised malady.

Autops Case Rep 2018 Oct-Dec;8(4):e2018065. Epub 2018 Dec 5.

Universidade de São Paulo, School of Medicine, Department of Surgery. São Paulo, SP, Brazil.

Histoplasmosis is a mycosis caused by the dimorphic fungus, , which is transmitted via dust and aerosols. Lung involvement is the most common, with a varied clinical presentation. Although it is not the only source of infection, is frequently found in bat guano, which is the reason why it is highly prevalent among caving practitioners. Read More

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http://dx.doi.org/10.4322/acr.2018.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360832PMC
December 2018
1 Read

Nasal septum ulcer as an isolated manifestation of histoplasmosis.

IDCases 2019 19;15:e00490. Epub 2019 Jan 19.

Department of Otorhinolaryngology and Head and Neck Surgery, University of Campinas/UNICAMP, Brazil.

Histoplasmosis is an infection caused by the dimorphic fungus , which is saprophyte of contaminated soil. In the immunocompetent host, the symptoms of histoplasmosis tend to be mild or even non-existent. In immunocompromised patients, the manifestations may be more severe and the disease manifests itself in a disseminated form, with high mortality rates. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360600PMC
January 2019
1 Read

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Mycoses 2019 Feb 8. Epub 2019 Feb 8.

Microbiology Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Many patients with histoplasmosis are treated with anti-tubercular therapy (ATT) in tuberculosis endemic regions as diagnosis of histoplasmosis requires invasive sampling. We sought to study the utility of urinary Histoplasma antigen detection test.

Methods: Case records of patients with a diagnosis of histoplasmosis prior to (Period A) and after (Period B) introduction of urinary Histoplasma antigen detection test were analysed in this single centre retrospective study. Read More

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http://doi.wiley.com/10.1111/myc.12902
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http://dx.doi.org/10.1111/myc.12902DOI Listing
February 2019
16 Reads

Histoplasma panniculitis in a patient with systemic lupus erythematosus.

An Bras Dermatol 2019 Jan-Feb;94(1):96-98

Department of Infectious Diseases, Hospital Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Histoplasmosis usually presents primarily as lung infection. Occasionally, mainly in immunocompromised hosts, it can spread and cause systemic manifestations. Skin lesions have been reported in 10 to 15 percent of cases of disseminated histoplasmosis, and panniculitis has been described as an unusual form of presentation in affected patients. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360956PMC
February 2019
3 Reads

[Histoplasmosis in AIDS patients without tegumentary manifestations].

Rev Chilena Infectol 2018 ;35(5):560-565

Unidad de Micología, Hospital de Enfermedades Infecciosas, Buenos Aires, Argentina.

Background: Histoplasmosis is a mycosis with a high prevalence in HIV/AIDS patients. Clinical presentation includes a wide spectrum of manifestations and diagnosis usually takes up to several weeks in patients who do not present cutaneous lesions.

Aim: To determine the clinical and microbiological characteristics as well as some biochemical parameters in patients with AIDS-associated histoplasmosis without tegumentary lesions, in order to develop a guideline which enables an early empiric treatment in cases of difficult diagnosis. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500560DOI Listing
January 2018
2 Reads

Acute Pulmonary Histoplasmosis Outbreak in A Documentary Film Crew Travelling from Guatemala to Australia.

Trop Med Infect Dis 2019 Feb 1;4(1). Epub 2019 Feb 1.

St Vincent's Pathology, St Vincent's Hospital (Melbourne), Victoria 3065, Australia.

is an endemic mycosis with a widespread distribution, although it is infrequently reported in travellers. In April 2018, five television crew members developed an acute febrile illness after filming a documentary about vampire bats in Guatemala. Patients developed symptoms after travelling to Australia, where they presented for medical care. Read More

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http://dx.doi.org/10.3390/tropicalmed4010025DOI Listing
February 2019
2 Reads

Histoplasmosis Infection of Aortobifemoral Graft Treated with a Neoaortoiliac System.

Ann Vasc Surg 2019 Jan 31. Epub 2019 Jan 31.

UT Southwestern Medical Center, Dallas, TX.

Aortic graft infections are a feared complication of aortic bypass operations and impart significant morbidity and mortality when they occur. The most common etiology is bacterial, with a presentation ranging from subclinical to acutely symptomatic depending on the organism. Fungal infections of prosthetic grafts are rare, especially in immunocompetent patients. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.10.029DOI Listing
January 2019
4 Reads

Complete resolution of erythrodermic psoriasis with first-line apremilast monotherapy.

BMJ Case Rep 2019 Jan 31;12(1). Epub 2019 Jan 31.

Pathology, Henry Ford Hospital, Detroit, Michigan.

Erythrodermic psoriasis (EP) is the most serious type of psoriasis with high morbidity and mortality. First-line recommended therapies for EP, cyclosporine and infliximab have significant adverse effects. Cyclosporine increases the risk of hypertension, leucopenia, infections and renal failure. Read More

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http://dx.doi.org/10.1136/bcr-2018-226959DOI Listing
January 2019
26 Reads

Oropharyngeal histoplasmosis: a report of 10 cases.

Clin Exp Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Mayo Clinic Florida, Jacksonville, FL, USA.

A wide differential diagnosis must be entertained in patients with unusual oral and pharyngeal ulcerations. A mucosal biopsy is essential. We retrospectively reviewed 10 cases from the Infectious Diseases Division at Mayo Clinic Rochester (MN, USA), in which the diagnosis proved to be Histoplasma capsulatum infection. Read More

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http://dx.doi.org/10.1111/ced.13927DOI Listing
February 2019
2 Reads

Solitary pulmonary nodule: An interesting clinical mimicry of pulmonary tuberculosis.

Med J Armed Forces India 2019 Jan 15;75(1):115-118. Epub 2018 Oct 15.

Assistant Professor (Lab Sciences & Molecular Med), Army Hospital (R&R), New Delhi 110010, India.

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http://dx.doi.org/10.1016/j.mjafi.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349671PMC
January 2019
8 Reads

Progressive disseminated histoplasmosis in Latin America and the Caribbean in people receiving highly active antiretroviral therapy for HIV infection: A systematic review.

Med Mycol 2019 Jan 18. Epub 2019 Jan 18.

Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.

Histoplasmosis is the most clinically significant mycosis in Latin America; still it has been neglected in people with human immunodeficiency virus (HIV). There is limited information about its contribution to morbidity and mortality in this population. We conducted a systematic review of scientific literature to provide an estimation of the frequency and mortality of histoplasmosis among people with HIV receiving highly active antiretroviral therapy (HAART) in Latin America, and factors associated with mortality. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy143DOI Listing
January 2019
12 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
4 Reads

Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition.

Med Mycol Case Rep 2019 Mar 22;23:62-64. Epub 2018 Dec 22.

Division of Infectious Diseases, University of Washington, Harborview Medical Center, Seattle, WA 98104, United States.

Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in mitigating IRIS related to disseminated endemic fungal infections. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325068PMC
March 2019
2 Reads

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
4 Reads

Clinical outcomes and cortical reserve in adrenal histoplasmosis-A retrospective follow-up study of 40 patients.

Clin Endocrinol (Oxf) 2019 Apr 10;90(4):534-541. Epub 2019 Feb 10.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Objective: Detailed studies of Addison's disease resulting from disseminated adrenal histoplasmosis (AH) are not available. We describe the presentation and prognosis of AH and cortisol status before and after antifungal therapy.

Design: Single-centre retrospective hospital-based study of 40 consecutive adults with AH [39 males; age (mean ± SD) 53 ± 11 years] was conducted between 2006 and 2018. Read More

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http://doi.wiley.com/10.1111/cen.13935
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http://dx.doi.org/10.1111/cen.13935DOI Listing
April 2019
13 Reads

Case Report: Hemophagocytic Lymphohistiocytosis Caused by Disseminated Histoplasmosis in a Venezuelan Patient with HIV and Epstein-Barr Virus Reactivation Who Traveled to Japan.

Am J Trop Med Hyg 2019 Feb;100(2):365-367

AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.

We describe a Venezuelan visitor to Japan who was diagnosed with hemophagocytic lymphohistiocytosis (HLH). The patient was also diagnosed with human immunodeficiency virus (HIV) and Epstein-Barr virus infection by the Western blot and polymerase chain reaction (PCR) tests, respectively. The cause of HLH was considered to be these two infections at first; however, the patient did not recover with antiretroviral/anti-herpes virus therapy. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367636PMC
February 2019
4 Reads

Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Bacteremia in Probable Neurosarcoidosis.

Authors:
Peter V Bui

Case Rep Med 2018 11;2018:3162403. Epub 2018 Dec 11.

Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.

Introduction: Neurosarcoidosis, either isolated or as part of systemic sarcoidosis, is an uncommon entity and has diagnostic uncertainty. Treatment for neurosarcoidosis can increase the risk of infections, including fungal infections such as disseminated histoplasmosis. Neurosarcoidosis may further predispose patients to infections of the central nervous system. Read More

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http://dx.doi.org/10.1155/2018/3162403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311783PMC
December 2018
5 Reads

Novel canine anti-Coccidioides immunoglobulin G enzyme immunoassay aids in diagnosis of coccidioidomycosis in dogs.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

MiraVista Diagnostics LLC. Indianapolis, Indiana, USA.

The diagnosis of coccidioidomycosis (CM) in dogs is typically based on clinical presentation, serology, and (less frequently) spherule identification. Agar gel immunodiffusion (AGID) is the most commonly employed serological method, but AGID is slow (requiring up to a week for titer). A Coccidioides antigen enzyme immunoassay (EIA) is also available; however, sensitivity is low in CM dogs. Read More

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http://dx.doi.org/10.1093/mmy/myy157DOI Listing
January 2019
2 Reads

Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography.

Clin Ophthalmol 2019 31;13:95-105. Epub 2018 Dec 31.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA,

Purpose: To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A).

Methods: This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. Read More

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http://dx.doi.org/10.2147/OPTH.S185468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318713PMC
December 2018
4 Reads

Infectious and Other Complications of Immunobiologic Agents.

Authors:
Peter Chin-Hong

Top Antivir Med 2019 Jan;26(4):100-103

University of California San Francisco, San Francisco, CA, USA.

Individuals with HIV infection are living longer, and are at risk of autoimmune disorders and cancers associated with aging. Many of these conditions are treated with immunobiologic agents that affect immune function and may increase risk of opportunistic infections (OIs) and other immune disorders in individuals with HIV infection. For example, tumor necrosis factor-alpha inhibitors, used to treat such disorders as Crohn's disease, are associated with risk of tuberculosis and histoplasmosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372358PMC
January 2019
15 Reads

Chronic progressive disseminated histoplasmosis in a renal transplant recipient.

Med Mycol Case Rep 2019 Mar 21;23:53-54. Epub 2018 Dec 21.

Division of Infectious Disease, Department of Internal Medicine, St. John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Detroit 48236, MI, United States of America.

Hematopoietic and solid organ transplant recipients are at increased risk of opportunistic infections and infections usually are severe due to impaired cell mediated immunity. We report an unusual case of disseminated histoplasmosis in a renal transplant recipient manifesting with a chronic progressive course over several years. After starting treatment with itraconazole, the patient showed marked improvement in his symptoms and had clinical resolution. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313815PMC
March 2019
3 Reads

Histoplasmosis presenting as an intrathoracic mass.

Lung India 2019 Jan-Feb;36(1):74-75

Department of Pathology, R.M.L.I.M.S, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/lungindia.lungindia_41_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330810PMC
January 2019
5 Reads

Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report.

BMC Infect Dis 2018 Dec 27;18(1):704. Epub 2018 Dec 27.

Medical student, Universidad Tecnológica de Pereira, Pereira, Colombia.

Background: Those infected by human immunodeficiency virus (HIV) have a higher risk of opportunistic infections. The risk is related to the level of immunosuppression. We report a case of a young male with the unusual scenario of three opportunistic infections occurring simultaneously: Cryptococcosis, Histoplasmosis and Cryptosporidiosis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3622-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307277PMC
December 2018
8 Reads

A challenging case of pyrexia of unknown origin: adrenal histoplasmosis mimicking tuberculosis in a patient with chronic hepatitis C.

Trop Doct 2018 Dec 28:49475518819622. Epub 2018 Dec 28.

1 Registrar, Department of Infectious Diseases, Apollo Hospitals, Hyderabad, Telangana, India.

We present an unusual case of fever of unknown origin with bilateral adrenal masses in a patient with compensated chronic liver disease (compensated) due to hepatitis C who had been treated elsewhere with four months of anti-tuberculous therapy for suspected disseminated tuberculosis (TB). At our institution, he underwent a CT-guided biopsy of the adrenal lesion which to our surprise did not reveal any evidence of TB but a close mimic. Read More

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http://dx.doi.org/10.1177/0049475518819622DOI Listing
December 2018
4 Reads

Lung Cancer Screening Reveals a Nonspiculated Nodule: Histoplasmosis.

J Glob Infect Dis 2018 Oct-Dec;10(4):226-227

Division of Infectious Diseases, Northport Veterans Affairs Medical Center, Northport, New York 11767, USA.

We report the case of a middle aged man, 43-pack-years active smoker, who upon radiographic screening for lung cancer found to have a non-spiculated lung nodule concerning for malignancy. Histologic evaluation of this lesion turned out to be a nodule due to . Read More

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http://dx.doi.org/10.4103/jgid.jgid_92_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276314PMC
December 2018
2 Reads

A case of pulmonary histoplasmosis diagnosed after lung lobectomy.

Surg Case Rep 2018 Dec 20;4(1):145. Epub 2018 Dec 20.

Department of Surgery, Yaizu City Hospital, 1000, Dobara, Yaizu, Shizuoka, Japan.

Background: Histoplasmosis is considered a fairly rare imported mycosis in Japan. Here we report a case of histoplasmosis describing the preoperative findings, histopathological findings, supposed infection route, and appropriate treatment, including the postoperative management.

Case Presentation: A healthy 65-year-old man was found at routine medical check-up to have an abnormal opacity on chest radiography. Read More

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http://dx.doi.org/10.1186/s40792-018-0554-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301901PMC
December 2018
3 Reads

Unusual case of cellulitis due to primary cutaneous histoplasmosis.

BMJ Case Rep 2018 Dec 14;11(1). Epub 2018 Dec 14.

Internal Medicine, University of Illinois College of Medicine, Urbana, Illinois, USA.

A 63-year-old white man with a history of rheumatoid arthritis on adalimumab was admitted to the hospital for left arm swelling and erythema. On physical examination, the patient was afebrile and non-toxic appearing and there was tense oedema of the left forearm. Initial laboratory work was unremarkable except for elevated inflammatory markers. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226621
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http://dx.doi.org/10.1136/bcr-2018-226621DOI Listing
December 2018
12 Reads