7,025 results match your criteria Histoplasmosis


Nasal septum ulcer as an isolated manifestation of histoplasmosis.

IDCases 2019 19;15:e00490. Epub 2019 Jan 19.

Department of Otorhinolaryngology and Head and Neck Surgery, University of Campinas/UNICAMP, Brazil.

Histoplasmosis is an infection caused by the dimorphic fungus , which is saprophyte of contaminated soil. In the immunocompetent host, the symptoms of histoplasmosis tend to be mild or even non-existent. In immunocompromised patients, the manifestations may be more severe and the disease manifests itself in a disseminated form, with high mortality rates. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360600PMC
January 2019

Can urinary histoplasma antigen test improve the diagnosis of histoplasmosis in a tuberculosis endemic region?

Mycoses 2019 Feb 8. Epub 2019 Feb 8.

Microbiology Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Many patients with histoplasmosis are treated with anti-tubercular therapy (ATT) in tuberculosis endemic regions as diagnosis of histoplasmosis requires invasive sampling. We sought to study the utility of urinary Histoplasma antigen detection test.

Methods: Case records of patients with a diagnosis of histoplasmosis prior to (Period A) and after (Period B) introduction of urinary Histoplasma antigen detection test were analysed in this single centre retrospective study RESULTS: Thirty seven patients (18 in period A, and 19 patients in period B) were studied. Read More

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http://doi.wiley.com/10.1111/myc.12902
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http://dx.doi.org/10.1111/myc.12902DOI Listing
February 2019
4 Reads

Histoplasma panniculitis in a patient with systemic lupus erythematosus.

An Bras Dermatol 2019 Jan-Feb;94(1):96-98

Department of Infectious Diseases, Hospital Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Histoplasmosis usually presents primarily as lung infection. Occasionally, mainly in immunocompromised hosts, it can spread and cause systemic manifestations. Skin lesions have been reported in 10 to 15 percent of cases of disseminated histoplasmosis, and panniculitis has been described as an unusual form of presentation in affected patients. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20197636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360956PMC
September 2017
2 Reads

[Histoplasmosis in AIDS patients without tegumentary manifestations].

Rev Chilena Infectol 2018 ;35(5):560-565

Unidad de Micología, Hospital de Enfermedades Infecciosas, Buenos Aires, Argentina.

Background: Histoplasmosis is a mycosis with a high prevalence in HIV/AIDS patients. Clinical presentation includes a wide spectrum of manifestations and diagnosis usually takes up to several weeks in patients who do not present cutaneous lesions.

Aim: To determine the clinical and microbiological characteristics as well as some biochemical parameters in patients with AIDS-associated histoplasmosis without tegumentary lesions, in order to develop a guideline which enables an early empiric treatment in cases of difficult diagnosis. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500560DOI Listing
January 2018
1 Read

Acute Pulmonary Histoplasmosis Outbreak in A Documentary Film Crew Travelling from Guatemala to Australia.

Trop Med Infect Dis 2019 Feb 1;4(1). Epub 2019 Feb 1.

St Vincent's Pathology, St Vincent's Hospital (Melbourne), Victoria 3065, Australia.

is an endemic mycosis with a widespread distribution, although it is infrequently reported in travellers. In April 2018, five television crew members developed an acute febrile illness after filming a documentary about vampire bats in Guatemala. Patients developed symptoms after travelling to Australia, where they presented for medical care. Read More

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http://dx.doi.org/10.3390/tropicalmed4010025DOI Listing
February 2019
1 Read

Histoplasmosis Infection of Aortobifemoral Graft Treated with a Neo-Aortoiliac System (NAIS).

Ann Vasc Surg 2019 Jan 31. Epub 2019 Jan 31.

UT Southwestern Medical Center, Dallas, TX.

Aortic graft infections are a feared complication of aortic bypass operations and impart significant morbidity and mortality when they occur. The most common etiology is bacterial, with a presentation ranging from subclinical to acute depending on the organism. Fungal infections of prosthetic grafts are rare, especially in immunocompetent patients. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.10.029DOI Listing
January 2019
2 Reads

Complete resolution of erythrodermic psoriasis with first-line apremilast monotherapy.

BMJ Case Rep 2019 Jan 31;12(1). Epub 2019 Jan 31.

Pathology, Henry Ford Hospital, Detroit, Michigan.

Erythrodermic psoriasis (EP) is the most serious type of psoriasis with high morbidity and mortality. First-line recommended therapies for EP, cyclosporine and infliximab have significant adverse effects. Cyclosporine increases the risk of hypertension, leucopenia, infections and renal failure. Read More

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http://dx.doi.org/10.1136/bcr-2018-226959DOI Listing
January 2019
14 Reads

Oropharyngeal histoplasmosis: a report of 10 cases.

Clin Exp Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Mayo Clinic Florida, Jacksonville, FL, USA.

A wide differential diagnosis must be entertained in patients with unusual oral and pharyngeal ulcerations. A mucosal biopsy is essential. We retrospectively reviewed 10 cases from the Infectious Diseases Division at Mayo Clinic Rochester (MN, USA), in which the diagnosis proved to be Histoplasma capsulatum infection. Read More

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http://dx.doi.org/10.1111/ced.13927DOI Listing
February 2019
1 Read

Solitary pulmonary nodule: An interesting clinical mimicry of pulmonary tuberculosis.

Med J Armed Forces India 2019 Jan 15;75(1):115-118. Epub 2018 Oct 15.

Assistant Professor (Lab Sciences & Molecular Med), Army Hospital (R&R), New Delhi 110010, India.

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http://dx.doi.org/10.1016/j.mjafi.2018.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349671PMC
January 2019
2 Reads

Progressive disseminated histoplasmosis in Latin America and the Caribbean in people receiving highly active antiretroviral therapy for HIV infection: A systematic review.

Med Mycol 2019 Jan 18. Epub 2019 Jan 18.

Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.

Histoplasmosis is the most clinically significant mycosis in Latin America; still it has been neglected in people with human immunodeficiency virus (HIV). There is limited information about its contribution to morbidity and mortality in this population. We conducted a systematic review of scientific literature to provide an estimation of the frequency and mortality of histoplasmosis among people with HIV receiving highly active antiretroviral therapy (HAART) in Latin America, and factors associated with mortality. Read More

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https://academic.oup.com/mmy/advance-article/doi/10.1093/mmy
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http://dx.doi.org/10.1093/mmy/myy143DOI Listing
January 2019
4 Reads

Endemic pulmonary fungal diseases in immunocompetent patients: an emphasis on thoracic imaging.

Expert Rev Respir Med 2019 Mar 31;13(3):263-277. Epub 2019 Jan 31.

a Department of Radiology , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Introduction: Systemic endemic mycoses are prevalent in specific geographical areas of the world and are responsible for high rates of morbidity and mortality in these populations, and in immigrants and travelers returning from endemic regions. The most common fungal infections that can affect the lungs of immunocompetent patients include histoplasmosis, coccidioidomycosis, paracoccidioidomycosis, blastomycosis, sporotrichosis, aspergillosis, and cryptococcosis. Diagnosis and management of these diseases remain challenging, especially in non-endemic areas due to the lack of experience. Read More

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http://dx.doi.org/10.1080/17476348.2019.1571914DOI Listing
March 2019
1 Read

Immune reconstitution inflammatory syndrome associated with disseminated histoplasmosis and TNF-alpha inhibition.

Med Mycol Case Rep 2019 Mar 22;23:62-64. Epub 2018 Dec 22.

Division of Infectious Diseases, University of Washington, Harborview Medical Center, Seattle, WA 98104, United States.

Endemic fungal infections are a significant problem for patients on TNF-alpha inhibitors. Immune reconstitution inflammatory syndrome, IRIS, can present in patients with waning TNF-alpha inhibition and an endemic fungal infection. There may be a potential role that TNF-alpha inhibitors can play in mitigating IRIS related to disseminated endemic fungal infections. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325068PMC
March 2019
1 Read

Clinical Characteristics and Etiologies of Miliary Nodules in the US: A Single-Center Study.

Am J Med 2019 Jan 16. Epub 2019 Jan 16.

Divisions of Critical Care, Pulmonary and Sleep Medicine, Department of Internal Medicine. Electronic address:

Background: Miliary nodules have been typically described as a radiological manifestation of disseminated tuberculosis. However, miliary nodules are known to occur in a wide variety of conditions. The primary objective of the study was to identify clinical characteristics and etiologies of miliary nodules within our institution. Read More

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http://dx.doi.org/10.1016/j.amjmed.2018.12.030DOI Listing
January 2019
2 Reads

Clinical outcomes and cortical reserve in adrenal histoplasmosis-A retrospective follow-up study of 40 patients.

Clin Endocrinol (Oxf) 2019 Jan 17. Epub 2019 Jan 17.

Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Objective: Detailed studies of Addison's disease resulting from disseminated adrenal histoplasmosis (AH) are not available. We describe the presentation and prognosis of AH and cortisol status before and after antifungal therapy.

Design: Single-centre retrospective hospital-based study of 40 consecutive adults with AH [39 males; age (mean ± SD) 53 ± 11 years] was conducted between 2006 and 2018. Read More

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http://doi.wiley.com/10.1111/cen.13935
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http://dx.doi.org/10.1111/cen.13935DOI Listing
January 2019
7 Reads

Case Report: Hemophagocytic Lymphohistiocytosis Caused by Disseminated Histoplasmosis in a Venezuelan Patient with HIV and Epstein-Barr Virus Reactivation Who Traveled to Japan.

Am J Trop Med Hyg 2019 Feb;100(2):365-367

AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.

We describe a Venezuelan visitor to Japan who was diagnosed with hemophagocytic lymphohistiocytosis (HLH). The patient was also diagnosed with human immunodeficiency virus (HIV) and Epstein-Barr virus infection by the Western blot and polymerase chain reaction (PCR) tests, respectively. The cause of HLH was considered to be these two infections at first; however, the patient did not recover with antiretroviral/anti-herpes virus therapy. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367636PMC
February 2019
2 Reads

Disseminated Histoplasmosis with Miliary Histoplasmosis, Neurohistoplasmosis, and Bacteremia in Probable Neurosarcoidosis.

Authors:
Peter V Bui

Case Rep Med 2018 11;2018:3162403. Epub 2018 Dec 11.

Department of Emergency Medicine, University of Michigan, Ann Arbor, MI, USA.

Introduction: Neurosarcoidosis, either isolated or as part of systemic sarcoidosis, is an uncommon entity and has diagnostic uncertainty. Treatment for neurosarcoidosis can increase the risk of infections, including fungal infections such as disseminated histoplasmosis. Neurosarcoidosis may further predispose patients to infections of the central nervous system. Read More

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http://dx.doi.org/10.1155/2018/3162403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311783PMC
December 2018
4 Reads

Novel canine anti-Coccidioides immunoglobulin G enzyme immunoassay aids in diagnosis of coccidioidomycosis in dogs.

Med Mycol 2019 Jan 12. Epub 2019 Jan 12.

MiraVista Diagnostics LLC. Indianapolis, Indiana, USA.

The diagnosis of coccidioidomycosis (CM) in dogs is typically based on clinical presentation, serology, and (less frequently) spherule identification. Agar gel immunodiffusion (AGID) is the most commonly employed serological method, but AGID is slow (requiring up to a week for titer). A Coccidioides antigen enzyme immunoassay (EIA) is also available; however, sensitivity is low in CM dogs. Read More

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http://dx.doi.org/10.1093/mmy/myy157DOI Listing
January 2019
1 Read

Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography.

Clin Ophthalmol 2019 31;13:95-105. Epub 2018 Dec 31.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA,

Purpose: To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A).

Methods: This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. Read More

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http://dx.doi.org/10.2147/OPTH.S185468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318713PMC
December 2018
2 Reads

Infectious and Other Complications of Immunobiologic Agents.

Authors:
Peter Chin-Hong

Top Antivir Med 2019 Jan;26(4):100-103

University of California San Francisco, San Francisco, CA, USA.

Individuals with HIV infection are living longer, and are at risk of autoimmune disorders and cancers associated with aging. Many of these conditions are treated with immunobiologic agents that affect immune function and may increase risk of opportunistic infections (OIs) and other immune disorders in individuals with HIV infection. For example, tumor necrosis factor-alpha inhibitors, used to treat such disorders as Crohn's disease, are associated with risk of tuberculosis and histoplasmosis. Read More

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January 2019
6 Reads

Chronic progressive disseminated histoplasmosis in a renal transplant recipient.

Med Mycol Case Rep 2019 Mar 21;23:53-54. Epub 2018 Dec 21.

Division of Infectious Disease, Department of Internal Medicine, St. John Hospital and Medical Center, 19251 Mack Avenue, Suite 340, Detroit 48236, MI, United States of America.

Hematopoietic and solid organ transplant recipients are at increased risk of opportunistic infections and infections usually are severe due to impaired cell mediated immunity. We report an unusual case of disseminated histoplasmosis in a renal transplant recipient manifesting with a chronic progressive course over several years. After starting treatment with itraconazole, the patient showed marked improvement in his symptoms and had clinical resolution. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313815PMC
March 2019
2 Reads

Histoplasmosis presenting as an intrathoracic mass.

Lung India 2019 Jan-Feb;36(1):74-75

Department of Pathology, R.M.L.I.M.S, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/lungindia.lungindia_41_18DOI Listing
January 2019
1 Read

Cryptococcal fungemia and probable histoplasmosis in a patient infected with HIV. Case report.

BMC Infect Dis 2018 Dec 27;18(1):704. Epub 2018 Dec 27.

Medical student, Universidad Tecnológica de Pereira, Pereira, Colombia.

Background: Those infected by human immunodeficiency virus (HIV) have a higher risk of opportunistic infections. The risk is related to the level of immunosuppression. We report a case of a young male with the unusual scenario of three opportunistic infections occurring simultaneously: Cryptococcosis, Histoplasmosis and Cryptosporidiosis. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3622-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307277PMC
December 2018
5 Reads

A challenging case of pyrexia of unknown origin: adrenal histoplasmosis mimicking tuberculosis in a patient with chronic hepatitis C.

Trop Doct 2018 Dec 28:49475518819622. Epub 2018 Dec 28.

1 Registrar, Department of Infectious Diseases, Apollo Hospitals, Hyderabad, Telangana, India.

We present an unusual case of fever of unknown origin with bilateral adrenal masses in a patient with compensated chronic liver disease (compensated) due to hepatitis C who had been treated elsewhere with four months of anti-tuberculous therapy for suspected disseminated tuberculosis (TB). At our institution, he underwent a CT-guided biopsy of the adrenal lesion which to our surprise did not reveal any evidence of TB but a close mimic. Read More

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http://dx.doi.org/10.1177/0049475518819622DOI Listing
December 2018
2 Reads

Lung Cancer Screening Reveals a Nonspiculated Nodule: Histoplasmosis.

J Glob Infect Dis 2018 Oct-Dec;10(4):226-227

Division of Infectious Diseases, Northport Veterans Affairs Medical Center, Northport, New York 11767, USA.

We report the case of a middle aged man, 43-pack-years active smoker, who upon radiographic screening for lung cancer found to have a non-spiculated lung nodule concerning for malignancy. Histologic evaluation of this lesion turned out to be a nodule due to . Read More

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http://dx.doi.org/10.4103/jgid.jgid_92_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276314PMC
December 2018
1 Read

A case of pulmonary histoplasmosis diagnosed after lung lobectomy.

Surg Case Rep 2018 Dec 20;4(1):145. Epub 2018 Dec 20.

Department of Surgery, Yaizu City Hospital, 1000, Dobara, Yaizu, Shizuoka, Japan.

Background: Histoplasmosis is considered a fairly rare imported mycosis in Japan. Here we report a case of histoplasmosis describing the preoperative findings, histopathological findings, supposed infection route, and appropriate treatment, including the postoperative management.

Case Presentation: A healthy 65-year-old man was found at routine medical check-up to have an abnormal opacity on chest radiography. Read More

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http://dx.doi.org/10.1186/s40792-018-0554-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301901PMC
December 2018
2 Reads

Unusual case of cellulitis due to primary cutaneous histoplasmosis.

BMJ Case Rep 2018 Dec 14;11(1). Epub 2018 Dec 14.

Internal Medicine, University of Illinois College of Medicine, Urbana, Illinois, USA.

A 63-year-old white man with a history of rheumatoid arthritis on adalimumab was admitted to the hospital for left arm swelling and erythema. On physical examination, the patient was afebrile and non-toxic appearing and there was tense oedema of the left forearm. Initial laboratory work was unremarkable except for elevated inflammatory markers. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226621
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http://dx.doi.org/10.1136/bcr-2018-226621DOI Listing
December 2018
5 Reads

Cryptococcal meningitis is a cause for cross-reactivity in cerebrospinal fluid assays for anti-Histoplasma, anti-Coccidioides and anti-Blastomyces antibodies.

Mycoses 2018 Dec 19. Epub 2018 Dec 19.

MiraVista Diagnostics, Indianapolis, Indianapolis, Indiana.

Background/objectives: Antibody detection is commonly used for diagnosis of histoplasmosis, and cross-reactions have been recognised due to endemic mycoses but not cryptococcosis. We observed cross-reactions in an anti-Histoplasma antibody enzyme immunoassay (EIA) in the cerebrospinal fluid (CSF) from a patient with cryptococcal meningitis and sought to assess the risk of cross-reactive anti-Histoplasma antibodies in persons with cryptococcal meningitis.

Methods: An anti-cryptococcal antibody EIA was developed to measure CSF antibody response in HIV-infected subjects from Kampala, Uganda and previously healthy, HIV-negative subjects at the National Institutes of Health (NIH) with cryptococcal meningitis. Read More

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http://dx.doi.org/10.1111/myc.12882DOI Listing
December 2018
4 Reads

Acute histoplasmosis in immunocompetent travelers: a systematic review of literature.

BMC Infect Dis 2018 Dec 18;18(1):673. Epub 2018 Dec 18.

Clinica Malattie Infettive, Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Azienda Ospedaliera Umberto I° Via Conca Torrette, Ancona, Italy.

Background: Histoplasmosis is a fungal infection highly endemic in the American continent. The disease can be severe in immunocompromised subjects. In immunocompetent subjects the clinical manifestations are variable. Read More

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http://dx.doi.org/10.1186/s12879-018-3476-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299618PMC
December 2018
1 Read

Role of western blot assay for the diagnosis of histoplasmosis in AIDS patients from a National Institute of Infectious Diseases in Rio de Janeiro, Brazil.

Mycoses 2018 Dec 18. Epub 2018 Dec 18.

Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.

Background: Histoplasmosis is a frequent fungal infection in HIV/AIDS patients, with high morbimortality rates when diagnosis and treatment are delayed. Antibody detection, which is faster than the gold standard culture test, hastens the laboratory investigation.

Objectives: To evaluate the role of WB for antibody detection in the diagnosis of histoplasmosis among HIV/AIDS patients. Read More

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http://dx.doi.org/10.1111/myc.12877DOI Listing
December 2018
2 Reads

A monoclonal antibody-based urine Histoplasma antigen enzyme immunoassay (IMMY®) for the diagnosis of histoplasmosis in cats.

J Vet Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Department of Statistics, Oklahoma State University, Stillwater, Oklahoma.

Background: An in-house Histoplasma urine antigen test for cats might be desirable in certain situations.

Objective: To validate and compare the diagnostic performance of a monoclonal antibody-based IMMY urine Histoplasma antigen enzyme immunoassay (IMMY EIA) to the commercially available urine Histoplasma antigen enzyme immunoassay (MiraVista Diagnostics, MV EIA).

Animals: One hundred ninety-three urine samples from 105 client-owned and purpose-bred research cats. Read More

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http://dx.doi.org/10.1111/jvim.15379DOI Listing
December 2018
1 Read

Histoplasmosis as a Complication of Inflammatory Bowel Disease Therapy: A Case Series.

Inflamm Bowel Dis 2018 Dec 13. Epub 2018 Dec 13.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1093/ibd/izy372DOI Listing
December 2018

An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: A proof of concept study.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.

Histoplasmosis is the most common endemic mycosis in the Americas. Currently, there is no laboratory test capable to detect subclinical or latent infections by Histoplasma capsulatum (Hc), which might develop as severe infections in immunocompromised individuals. For the first time to our knowledge, we explore the suitability of an interferon gamma release assay (IGRA) to detect latent Hc infection in asymptomatic individuals. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/mmy/myy131DOI Listing
December 2018
3 Reads

[Histoplasma capsulatum: an emerging agent in Chile?]

Rev Chilena Infectol 2018 ;35(3):309-311

Laboratorio Clínico, Hospital Lucio Córdova, Santiago, Chile.

In the last eleven months, we have diagnosed 9 cases of Histoplasmosis in our country. All patients affected were from endemic areas of South-America. Here, we wish to inform and prevent to all clinical laboratories from Chile about the presence of Histoplasma capsulatum in clinical samples. Read More

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http://dx.doi.org/10.4067/s0716-10182018000300309DOI Listing
January 2018
1 Read

Imported Acute Histoplasmosis in an Adolescent with Suspected Lymphoproliferative Syndrome.

Arch Bronconeumol 2018 Dec 5. Epub 2018 Dec 5.

Sección de Enfermedades Infecciosas Pediátricas, Servicio de Pediatría, Hospital General Universitario Gregorio Marañón, Madrid, España.

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http://dx.doi.org/10.1016/j.arbres.2018.11.001DOI Listing
December 2018
4 Reads

Histoplasmosis-induced ileal perforation in a patient with acquired immune deficiency syndrome: Case report.

JGH Open 2018 Aug 27;2(4):166-168. Epub 2018 Jun 27.

Gastroenterology Service, Clinica Angloamericana Lima Peru.

Intestinal involvement with disseminated histoplasmosis is common in some populations infected with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), especially in those who come from tropical zones. We report the case of a 29-year-old male patient, from a tropical zone, with HIV infection and a CD value less than 50 cells/mm, with a history of abdominal pain, fever, diarrhea, and weight loss. On presentation, he was pale, sweaty, and had abdominal rebound tenderness. Read More

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http://dx.doi.org/10.1002/jgh3.12048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152463PMC
August 2018
1 Read

Oropharyngeal histoplasmosis in an HIV-negative patient.

Ear Nose Throat J 2018 Oct-Nov;97(10-11):E49-E50

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

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November 2018
6 Reads

Primary cutaneous histoplasmosis.

Authors:
Blake Raggio

Ear Nose Throat J 2018 Oct-Nov;97(10-11):346-348

Department of Otolaryngology, Tulane University Medical Center, New Orleans, LA, USA.

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November 2018
2 Reads

Histoplasma capsulatum causing sinusitis: a case report in French Guiana and review of the literature.

BMC Infect Dis 2018 Nov 26;18(1):595. Epub 2018 Nov 26.

AcademicLaboratory of Parasitology and Mycology, Andrée Rosemon Hospital, 97306, Cayenne, French Guiana.

Background: American histoplasmosis is a mycosis caused by Histoplasma capsulatum. A variety of clinical features of histoplasmosis have been commonly described ranging from asymptomatic infections to severe pulmonary infections. In immunocompromised individuals, progressive disseminated forms are frequent, leading to fatal outcome if untreated. Read More

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http://dx.doi.org/10.1186/s12879-018-3499-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258161PMC
November 2018
1 Read

Macrophage activation by IFN-γ triggers restriction of phagosomal copper from intracellular pathogens.

PLoS Pathog 2018 11 19;14(11):e1007444. Epub 2018 Nov 19.

Department of Microbiology, Ohio State University, Columbus, OH, United States of America.

Copper toxicity and copper limitation can both be effective host defense mechanisms against pathogens. Tolerance of high copper by fungi makes toxicity as a defense mechanism largely ineffective against fungal pathogens. A forward genetic screen for Histoplasma capsulatum mutant yeasts unable to replicate within macrophages showed the Ctr3 copper transporter is required for intramacrophage proliferation. Read More

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http://dx.plos.org/10.1371/journal.ppat.1007444
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http://dx.doi.org/10.1371/journal.ppat.1007444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277122PMC
November 2018
2 Reads

Host membrane glycosphingolipids and lipid microdomains facilitate Histoplasma capsulatum internalisation by macrophages.

Cell Microbiol 2018 Nov 14:e12976. Epub 2018 Nov 14.

Department of General Microbiology, Microbiology Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Recognition and internalisation of intracellular pathogens by host cells is a multifactorial process, involving both stable and transient interactions. The plasticity of the host cell plasma membrane is fundamental in this infectious process. Here, the participation of macrophage lipid microdomains during adhesion and internalisation of the fungal pathogen Histoplasma capsulatum (Hc) was investigated. Read More

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http://dx.doi.org/10.1111/cmi.12976DOI Listing
November 2018
3 Reads

Feline histoplasmosis presenting with bone and joint involvement: clinical and diagnostic findings in 25 cats.

J Feline Med Surg 2018 Nov 8:1098612X18806706. Epub 2018 Nov 8.

2 Veterinary Clinical Sciences, Oklahoma State University Center for Veterinary Sciences, Stillwater, OK, USA.

Objectives: The aim of this study was to describe clinical and diagnostic findings in cats with bone and joint disease associated with histoplasmosis.

Methods: Medical records from between 2011 and 2017 were reviewed. Inclusion criteria required: (1) diagnosis of histoplasmosis by cytology, histology, urine or serum Histoplasma antigen testing, or culture; and (2) lameness or joint effusion as a presenting complaint or physical examination finding. Read More

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http://journals.sagepub.com/doi/10.1177/1098612X18806706
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http://dx.doi.org/10.1177/1098612X18806706DOI Listing
November 2018
10 Reads

Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea.

Osong Public Health Res Perspect 2018 Oct;9(5):255-260

Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon, Korea.

Objectives: Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed. Read More

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http://www.kcdcphrp.org/journal/view.html?doi=10.24171/j.phr
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http://dx.doi.org/10.24171/j.phrp.2018.9.5.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202016PMC
October 2018
8 Reads

Diagnostic accuracy cohort study and clinical value of the Histoplasma urine antigen (ALPHA Histoplasma EIA) for disseminated histoplasmosis among HIV infected patients: A multicenter study.

PLoS Negl Trop Dis 2018 11 5;12(11):e0006872. Epub 2018 Nov 5.

Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Mexico City, Mexico.

Background: The Histoplasma urine antigen (HUAg) is the preferred method to diagnose progressive disseminated histoplasmosis (PDH) in HIV patients. In 2007, IMMY ALPHA Histoplasma EIA was approved for clinical for on-site use, and therefore useful for regions outside the United States. However, ALPHA-HUAg is considered inferior to the MVista-HUAg which is only available on referral. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237426PMC
November 2018
1 Read

MANAGEMENT OF NEOVASCULAR OCULAR HISTOPLASMOSIS: Past and Present.

Authors:
Kevin J Blinder

Retina 2019 Feb;39(2):226-234

The Retina Institute, St. Louis, Missouri; and Ophthalmology and Visual Sciences, Washington University, St. Louis, Missouri.

Purpose: To review the wide variety of treatment modalities available for choroidal neovascularization secondary to the presumed ocular histoplasmosis syndrome.

Methods: A literature search was performed to review the multitude of studies conducted to investigate the efficacy and safety of treatment modalities available for choroidal neovascularization secondary to the presumed ocular histoplasmosis syndrome.

Results: Each treatment modality is reviewed, with the studies summarized and presented to support or refute the method of treatment. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002352DOI Listing
February 2019
2 Reads

Therapy of Non-Dermatophytic Mycoses in Animals.

Authors:
Daniel Elad

J Fungi (Basel) 2018 Oct 30;4(4). Epub 2018 Oct 30.

Department of Clinical Bacteriology and Mycology, The Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel.

This review focuses on aspects of antimycotic therapy specific to veterinary medicine. In the first part, drug availability, limited mostly by economic consideration but also by clinical applicability and specific adverse effects, is described for polyenes, 5 fluorocytosine, azoles, echinocandins and terbinafine. In the second part, current knowledge and experience in the treatment of selected fungal infections are overviewed. Read More

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http://dx.doi.org/10.3390/jof4040120DOI Listing
October 2018
2 Reads

[Histoplasma capsulatum electron microscopy isolated from a patient with disseminated histoplasmosis].

Rev Argent Microbiol 2018 Oct 27. Epub 2018 Oct 27.

Cátedra de Bacteriología y Micología, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.ram.2018.05.006DOI Listing
October 2018
2 Reads

Tomographic assessment of thoracic fungal diseases: a pattern and signs approach.

Radiol Bras 2018 Sep-Oct;51(5):313-321

Department of Radiology, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Pulmonary fungal infections, which can be opportunistic or endemic, lead to considerable morbidity and mortality. Such infections have multiple clinical presentations and imaging patterns, overlapping with those of various other diseases, complicating the diagnostic approach. Given the immensity of Brazil, knowledge of the epidemiological context of pulmonary fungal infections in the various regions of the country is paramount when considering their differential diagnoses. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/0100-3984.2017.0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198837PMC
October 2018
15 Reads

Recurrent Opportunistic Infections in a Thymectomised Patient with Myasthenia Gravis and Good's Syndrome.

Cureus 2018 Aug 10;10(8):e3130. Epub 2018 Aug 10.

Neurology, University of Missouri, Columbia, USA.

We report the case of a 65-year-old man with myasthenia gravis, who developed recurrent opportunistic infections following thymectomy and immunosuppressive therapy. Subsequent evaluation including immunological studies, flow cytometry, and bone marrow studies confirmed the diagnosis of Good's syndrome. The patient was successfully treated with intravenous immunoglobulin (IVIG) and has remained stable with a monthly IVIG regimen. Read More

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http://dx.doi.org/10.7759/cureus.3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181245PMC
August 2018
2 Reads

Accuracy of a Novel Histoplasmosis Enzyme Immunoassay to Evaluate Suspicious Lung Nodules.

Cancer Epidemiol Biomarkers Prev 2019 Feb 19;28(2):321-326. Epub 2018 Oct 19.

Tennessee Valley VA Healthcare System, Nashville, Tennessee.

Background: Granulomas caused by infectious lung diseases present as indeterminate pulmonary nodules (IPNs) on radiography. Newly available serum enzyme immunoassay (EIA) for histoplasmosis has not been studied for the evaluation of IPNs. We investigated serum biomarkers of histoplasmosis antibodies as an indication of benign disease in IPNs from a highly endemic region. Read More

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
Publisher Site
http://dx.doi.org/10.1158/1055-9965.EPI-18-0169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363824PMC
February 2019
13 Reads

Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: A systematic review of diagnostic accuracy studies.

PLoS Negl Trop Dis 2018 10 19;12(10):e0006802. Epub 2018 Oct 19.

CIC INSERM 1424, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.

Introduction: Disseminated histoplasmosis, a disease that often resembles and is mistaken for tuberculosis, is a major cause of death in patients with advanced HIV disease. Histoplasma antigen detection tests are an important addition to the diagnostic arsenal for patients with advanced HIV disease and should be considered for inclusion on the World Health Organization Essential Diagnostics List.

Objective: Our objective was to systematically review the literature to evaluate the diagnostic accuracy of Histoplasma antigen tests in the context of advanced HIV disease, with a focus on low- and middle-income countries. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209380PMC
October 2018
6 Reads