7,657 results match your criteria Histoplasmosis

Hemophagocytic Lymphohistiocytosis in the Setting of Disseminated Histoplasmosis and Uncontrolled HIV.

Cureus 2022 Apr 21;14(4):e24360. Epub 2022 Apr 21.

Internal Medicine, The University of Tennessee Health Science Center at Chattanooga, Chattanooga, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threateningly aggressive syndrome caused by excessive immune activation. It involves the abnormal activation of lymphocytes and macrophages which leads to tissue destruction and inflammation. Traditionally HLH classification is currently separated into primary and secondary HLH based on genetic versus nongenetic events such as infection, malignancy, or autoimmune disorders. Read More

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Notch regulates Histoplasma capsulatum clearance in mouse lungs during innate and adaptive immune response phases in primary infection.

J Leukoc Biol 2022 May 23. Epub 2022 May 23.

Department of Medicine, Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA, 234 Albert Sabin Way, Cincinnati, OH, 45267, United States.

The clearance of the pathogenic fungus, Histoplasma capsulatum, requires cooperation between innate and adaptive immunity. Since this organism is inhaled, lung macrophages and dendritic cells (DCs) are the first lines of defense. Moreover, DCs act as APCs to drive the education of type 1 Th cells to produce IFNγ, which contributes to the final elimination of H. Read More

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Prevalence of ocular lesions in cats newly diagnosed with histoplasmosis: 55 cases (2015-2022).

J Am Vet Med Assoc 2022 May 20:1-4. Epub 2022 May 20.

2Department of Veterinary Clinical Sciences, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK.

Objective: To describe the prevalence of ocular lesions in cats with newly diagnosed histoplasmosis.

Animals: 55 client-owned domestic cats.

Procedures: As part of this prospective case series, cats diagnosed with histoplasmosis between the years 2015 and 2020 underwent complete ophthalmic examinations by a board-certified veterinary ophthalmologist prior to the initiation of antifungal treatment. Read More

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A rare case of disseminated cutaneous histoplasmosis.

Indian J Dermatol Venereol Leprol 2022 Apr 26:1-4. Epub 2022 Apr 26.

Department of Dermatology, Osmania Medical College, Hyderabad, Telangana, India.

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Editorial: Immunological Memory to Fungal Infections and Vaccine Development.

Front Immunol 2022 27;13:880037. Epub 2022 Apr 27.

MRC Centre for Medical Mycology, University of Exeter, Exeter, United Kingdom.

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Integrating Public Health Surveillance and Environmental Data to Model Presence of Histoplasma in the United States.

Epidemiology 2022 May 5. Epub 2022 May 5.

Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC.

Background: In the United States, the true geographic distribution of the environmental fungus Histoplasma capsulatum remains poorly understood but appears to have changed since it was first characterized. Histoplasmosis is caused by inhalation of the fungus and can range in severity from asymptomatic to life-threatening. Due to limited public health surveillance and under detection of infections, it is challenging to directly use reported case data to characterize spatial risk. Read More

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Histoplasmosis acquired in Alberta, Canada: an epidemiological and genomic study.

Lancet Microbe 2021 May 3;2(5):e191-e197. Epub 2021 Mar 3.

Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Background: The classic geographical range of histoplasmosis in North America primarily includes the states and provinces adjacent to the Ohio, Mississippi, and St Lawrence riverways. Although Alberta, Canada is not typically considered a region of risk for histoplasmosis, cases with suspected local acquisition have been reported. We aimed to investigate the epidemiology and geographical distribution of cases of histoplasmosis in Alberta to assess evidence for local acquisition of infections, using genomic analysis for corroboration. Read More

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North American Endemic Fungal Infections.

Jeffrey P Kanne

Radiol Clin North Am 2022 May;60(3):409-427

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue MC 3252, Madison, WI 53792-3252, USA. Electronic address:

Histoplasmosis, blastomycosis, and coccidioidomycosis are endemic fungal infections in North America. Many infections are subclinical, and many symptomatic infections are mild. Pneumonia is the most common clinical manifestation. Read More

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Histoplasmosis presenting as colitis and blood dyscrasias in a patient with systemic lupus erythematosus.

Proc (Bayl Univ Med Cent) 2022 10;35(3):350-351. Epub 2022 Feb 10.

Division of Infectious Diseases, Department of Internal Medicine, Creighton University Medical Center , Omaha , Nebraska.

A 28-year-old woman with a history of systemic lupus erythematosus on hydroxychloroquine and steroid therapy presented with fever, dysentery, and thrombocytopenia. Marrow aspirate revealed yeast forms of histoplasmosis. She was treated with liposomal amphotericin B followed by itraconazole with resolution of symptoms and marrow recovery. Read More

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February 2022

[Histoplasmosis in a patient with sarcoidosis].

Ned Tijdschr Geneeskd 2022 04 26;166. Epub 2022 Apr 26.

Amsterdam UMC, afd. Interne Geneeskunde, Amsterdam.

Background: Histoplasmosis is an infection caused by inhalation of spores of the fungus Histoplasma capsulatum. H. capsulatum is not present in the Netherlands but can cause severe disseminated disease in the immunocompromised traveller, with high mortality rate, especially when diagnosis is delayed. Read More

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Let's talk about sex characteristics-As a risk factor for invasive fungal diseases.

Mycoses 2022 Apr 28. Epub 2022 Apr 28.

Durham County Department of Public Health, Durham, North Carolina, USA.

Biological sex, which comprises differences in host sex hormone homeostasis and immune responses, can have a substantial impact on the epidemiology of infectious diseases. Comprehensive data on sex distributions in invasive fungal diseases (IFDs) are lacking. In this review, we performed a literature search of in vitro/animal studies, clinical studies, systematic reviews and meta-analyses of invasive fungal infections. Read More

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A Case of Bilateral Adrenal Hemorrhage: The Exceptional Cause of Adrenal Insufficiency.

Cureus 2022 Mar 23;14(3):e23413. Epub 2022 Mar 23.

Internal Medicine, Oklahoma City Veterans Affairs (VA) Medical Center, Oklahoma City, USA.

Bilateral adrenal hemorrhage is an extremely uncommon and life-threatening condition. It is caused by multiple etiologies, including antiphospholipid syndrome, disseminated histoplasmosis, trauma, severe stress, and granulomatous disease. The authors present a unique case of a 64-year-old alcoholic male, who was admitted after fall and right hip fracture. Read More

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Hemophagocytic Lymphohistiocytosis Syndrome Secondary to Disseminated Histoplasmosis in a Presumably Immunocompetent Adolescent: A Novel Case.

Pediatr Hematol Oncol 2022 Apr 27:1-7. Epub 2022 Apr 27.

Division of Pediatric Hematology/Oncology, University of Kansas School of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

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Endobronchial histoplasmosis mimicking primary bronchogenic carcinoma during the COVID-19 pandemic.

J Bras Pneumol 2022 04 20;48(2):e20210048. Epub 2022 Apr 20.

. Departamento de Cirurgia Torácica, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP), Brasil.

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Right Vocal Cord Paralysis Caused by Histoplasmosis: A Case Report.

Ann Otol Rhinol Laryngol 2022 Apr 21:34894221090334. Epub 2022 Apr 21.

Section of Otolaryngology, Department of Surgery, University of Chicago Medicine, Chicago, IL, USA.

Objectives: is a prevalent dimorphic fungus, reaching an exposure rate of 90% in endemic areas such as the Midwest and Central United States. We report an unusual presentation of dysphonia due to right vocal cord paralysis caused by mediastinal lymphadenopathy from histoplasmosis.

Methods: A 73-year-old male presented to an otolaryngology clinic with 4 months of hoarseness. Read More

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Histoplasmosis masquerading as tuberculosis: A report of three cases in immunocompetent children.

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):406-409

Department of Pediatric Surgery, IPGMER, Kolkata, West Bengal, India.

The most common cause of granulomatous lymphadenitis in countries like ours is mycobactrium tuberculosis followed by atypical mycobacterial infection, fungal infections, parasitic infection, cat scratch disease, lymphogranuloma venereum (inguinal lymphadenopathy), and leprosy Here, we present three cases of lymphadenopathy due to histoplasmosis in immunocompetent children. Two of them presented with fever, lymphadenopathy, initially diagnosed as granulomatous lymphadenitis consistent with tuberculosis on FNAC and were put on antitubercular drugs. However, their condition gradually became worse. Read More

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Nasal cartilage destruction associated to cutaneous histoplasmosis in AIDS.

BMC Infect Dis 2022 Apr 14;22(1):377. Epub 2022 Apr 14.

Universidad Espíritu Santo, Samborondón, Ecuador.

Background: Systemic histoplasmosis is a disease of high morbidity and mortality in immunocompromised patients. Patients with AIDS get the infection through inhalation of spores, triggering a primary lung infection with a subsequent hematogenous spread to multiple organs, including the skin. Tissue necrosis have been documented in cutaneous histoplasmosis with multiple clinical manifestations that mimic other diseases. Read More

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Case Report: Histoplasma Hepatitis Presenting as Common Bile Duct Obstruction.

Am J Trop Med Hyg 2022 Apr 11. Epub 2022 Apr 11.

Department of Medicine, Gastroenterology and Hepatology, Hennepin Healthcare, Minneapolis, Minnesota.

Histoplasma capsulatum is the most common endemic mycosis in the United States and can cause disseminated histoplasmosis in immunocompromised patients.1 Although hepatic involvement is common with histoplasmosis, it can be challenging to diagnose. We report a case of a 50-year-old woman receiving adalimumab for rheumatoid arthritis who presented with right upper quadrant pain, fever, jaundice, and dyspnea. Read More

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A case of pulmonary histoplasmosis treated with voriconazole.

J Infect Dev Ctries 2022 Mar 31;16(3):570-574. Epub 2022 Mar 31.

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Histoplasmosis is an infection caused by the dimorphic fungus Histoplasma capsulatum. The lungs are the most common site of infection, especially in patients with immune deficiency. We report a case of 62-year-old male patient presented with cough for 3 months and had been taking immunosuppressive drugs for 10 years after heart transplantation. Read More

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Intramedullary histoplasmosis lesion in children: A case report.

Surg Neurol Int 2022 11;13:83. Epub 2022 Mar 11.

Neurosurgeon, Regional Hospital of Presidente Prudente, São Paulo, Brazil.

Background: Histoplasmosis is a fungal disease endemic in some regions of the United States of America, Canada, and Latin America. The geographic characteristics, humidity, soil, and climate are responsible for such distribution. In Brazil, there are case reports of histoplasmosis throughout its territory, being considered an endemic region. Read More

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Lung and Mediastinal Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in Young Adults.

Acta Cytol 2022 Apr 7:1-10. Epub 2022 Apr 7.

Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is used to investigate pulmonary nodules, mediastinal lymphadenopathy, and mediastinal masses in both malignant and nonmalignant etiologies. EBUS-TBNA is most commonly used in the diagnosis and staging of patients with non-small-cell lung cancer in the middle-age and elderly populations. As lung cancer is uncommon in young adults, it is assumed that there are a distinct disease population and clinical background in young adults who undergo EBUS-TBNA. Read More

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Rare case of endocarditis in a patient with a prosthetic valve.

Eur Heart J Case Rep 2022 Mar 25;6(3):ytac086. Epub 2022 Feb 25.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA.

Background: Diagnosis of fungal endocarditis can be challenging, especially among cases with negative blood culture results. Of fungal endocarditis cases, constitutes an even smaller proportion with ∼58 prior cases reported. Due to the rarity of histoplasmosis endocarditis and thus limited data, there is no current diagnostic guideline for testing within culture negative infective endocarditis. Read More

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Progressive disseminated histoplasmosis in HIV-positive patients.

Int J STD AIDS 2022 May 28;33(6):544-553. Epub 2022 Mar 28.

Medical Sciences Post-Graduate Program, Department of Internal Medicine, 28121Federal University of Ceará, Fortaleza, Brazil.

Background: Histoplasmosis is the most common endemic mycosis among people living with advanced HIV infection.

Purpose: Describe general aspects and challenges of this disease and its association with HIV.

Research Design: Review of literature. Read More

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"Disseminated histoplasmosis and erythrophagocytosis in an immunocompromised host: the role of bone marrow evaluation for prompt diagnosis of invasive fungal infections".

Int J Infect Dis 2022 06 24;119:10-12. Epub 2022 Mar 24.

Department of Hematology, Hemotherapy & Cell Therapy, University of Sao Paulo, Sao Paulo, Brazil; Laboratory of Medical Investigation in Pathogenesis and Directed Therapy in Onco-Immuno-Hematology (LIM-31), University of Sao Paulo, Sao Paulo, Brazil.

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Endemic mycoses: geographical distribution is still a work in progress.

Lancet Infect Dis 2022 04;22(4):451

III Divison of Infectious Diseases, ASST Fatebenefratelli-Sacco, Luigi Sacco University Hospital, Milan, Italy.

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A Rare Case of Plasmablastic Lymphoma in a Patient with HIV and SARS-CoV-2 Infections.

Curr Oncol 2022 03 2;29(3):1537-1543. Epub 2022 Mar 2.

Faculty of Medicine, "Ovidius" University of Constanta, 900470 Constanta, Romania.

Lesions commonly associated with HIV infection include oral candidiasis, herpes simplex infection, oral Kaposi's sarcoma, hairy leukoplakia, periodontal diseases (linear gingival erythema and necrotizing ulcerative periodontitis), xerostomia, human papillomavirus-associated warts, aphthous ulcers, non-Hodgkin's lymphoma, histoplasmosis, carcinoma, exfoliative cheilitis, and HIV salivary gland disease. Non-Hodgkin's lymphoma (NHL) is the most common cancer in people living with HIV (PLWH), and the incidence is increased for aggressive B-cell NHL. Plasmablastic lymphoma (PbL) is a rare and aggressive B-cell malignancy that is often unresponsive to chemotherapy and usually has a poor prognosis. Read More

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Retraction: Histoplasmosis affecting oral mucosa in an immunocompetent patient: A rarity in non-disseminated disease.


Indian J Dermatol Venereol Leprol 2022 Mar-Apr;88(2):277

The article titled "Histoplasmosis affecting oral mucosa in an immunocompetent patient: A rarity in non-disseminated disease"1, published on pages 214-216, issue 2, volume 88 of the Indian Journal ofDermatology, Venereology, and Leprology (IJDVL), has been retracted by the Editorial Board of the journal following an investigation. It has been noted that Figure 2 of their published article is the one and the same as the upper panel of Figure 3 of another article published by Sen et al in the Indian Journal Dermatology (IJD). Also, the Editorial Board notes the fact that neither did the authors cite the earlier published article in the article published in the current issue of our journal, nor did they offer any explanation for the same when specifically queried upon why they had not done that. Read More

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Disseminated histoplasmosis in an AIDS patient with immunologic non-response to HAART: A case report.

J Mycol Med 2022 Mar 8;32(3):101271. Epub 2022 Mar 8.

College of Medicine, University of Lagos, Nigeria.

Histoplasmosis in Africa is caused by Histoplasma capsulatum var duboisii (Hcd) and/or Histoplasma capsulatum var capsulatum (Hcc)[1]. It occurs predominantly in immunocompetent patients as localized disease and less commonly in HIV positive patients as disseminated disease [2]. The most significant risk factor for histoplasmosis in Africa is HIV [3]. Read More

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Oral Histoplasmosis Presenting as a Solitary Ulcer on Tongue in an Immunocompetent Adult.

Am J Med 2022 Mar 13. Epub 2022 Mar 13.

Department of Neurology, Bangur Institute of Neurosciences, Kolkata, West Bengal, India.

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