8,190 results match your criteria Histopathology [Journal]


Clinicopathological Evaluation of PD1/PD-L1 Axis in Post-Transplant Lymphoproliferative Disorders: Association with EBV, PD-L1 Copy Number Alterations and Outcome.

Histopathology 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Hospital Clinic, Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

Aims: The clinical implications of programmed cell death 1 (PD1)/ programmed cell death-ligand 1 (PD-L1) axis in post-transplant lymphoproliferative disorders are largely unknown and its association with Epstein-Barr virus (EBV) status and PD-L1 copy number alterations (CNAs) has not been thoroughly studied.

Methods And Results: PD1/PD-L1 expression was studied in 50 adult post-transplant lymphoproliferative disorders and the correlation with PD-L1 CNAs, EBV, clinicopathological features and outcome was evaluated. Thirty-seven (74%) cases were classified as diffuse large B-cell lymphoma (DLBCL), 9 (18%) as polymorphic and 4 (8%) cases as classical Hodgkin lymphoma. Read More

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http://dx.doi.org/10.1111/his.13857DOI Listing

Spindle cells in aspiration material from an inguinal adenopathy: possibly a sheep in wolf's clothing!

Histopathology 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

A 37-year-old woman presented with a painless left inguinal mass. There was no medical history except for a paternal aunt carrying a BRCA mutation. Inguinal ultrasonography revealed a heterogeneous, hypoechoic adenopathy of 3 centimeters in diameter. Read More

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http://dx.doi.org/10.1111/his.13859DOI Listing

Hedgehog pathway proteins SMO and GLI expression as prognostic marker in head and neck squamous cell carcinoma - a retrospective immunohistochemical study.

Histopathology 2019 Mar 12. Epub 2019 Mar 12.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

Background: Since the hedgehog signaling pathway plays a major role in many types of cancer and can nowadays be targeted by specific compounds, we aimed to investigate the role of this pathway in squamous cell carcinoma of the head and neck.

Materials And Methods: Ninety-eight treatment naïve head and neck cancer specimens were immunohistologically stained for SMO, GLI-1, p53 and p16 expression and correlated with clinico-pathological factors.

Results: Immunoreactivity for SMO and GLI-1 was found in 20 (20. Read More

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http://dx.doi.org/10.1111/his.13860DOI Listing

Florid T-follicular helper cell hyperplasia associated with extranodal marginal zone lymphoma: a diagnostic pitfall which may mimic T cell lymphoma.

Histopathology 2019 Mar 12. Epub 2019 Mar 12.

Department of Cellular Pathology, The Royal Marsden Hospital, London, SW3 6JJ.

A 62-year old female with a history of myasthenia gravis presented in January 2016 with worsening diplopia. There was a left orbital mass with initial biopsy showing fibrosis and minimal chronic inflammation, insufficient for a diagnosis of lymphoma. Anaemia was detected on routine blood tests in November 2016. Read More

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http://dx.doi.org/10.1111/his.13858DOI Listing

Primary Renal Well-differentiated Neuroendocrine Tumor (Carcinoid): Next- Generation Sequencing Study of 11 Cases.

Histopathology 2019 Mar 9. Epub 2019 Mar 9.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzen, Pilsen, Czech Republic.

Aims: Primary renal well-differentiated neuroendocrine tumor (hereafter referred to as renal NET) is rare, with approximately 100 cases reported in the literature. There is also limited data available on the molecular genetic background of primary renal NETs.

Methods: We analyzed 11 renal NETs using next generation sequencing (NGS) to identify characteristic genetic aberrations. Read More

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http://dx.doi.org/10.1111/his.13856DOI Listing
March 2019
1 Read

Clinical-pathological Correlations in Post-Transplant Thrombotic Microangiopathy.

Histopathology 2019 Mar 9. Epub 2019 Mar 9.

Imperial College, Faculty of Medicine, London, UK.

Aims: Post-transplant thrombotic microangiopathy (TMA) is a rare and clinically challenging finding in renal transplant biopsies. In addition to recurrent atypical haemolytic uremic syndrome (aHUS), TMA in renal transplants is associated with various conditions, such as calcineurin-inhibitor (CNI) treatment, antibody-mediated rejection (ABMR), viral infections, sepsis, pregnancy, malignancies or surgery. The therapeutic implications of this diagnosis are considerable. Read More

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http://dx.doi.org/10.1111/his.13855DOI Listing

Micropapillary Variant of Mucinous Carcinomas of the Breast Display Genetic Alterations Intermediate Between Mucinous Carcinomas and Micropapillary Carcinomas.

Histopathology 2019 Mar 7. Epub 2019 Mar 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Aims: Micropapillary variant of mucinous carcinoma of the breast (MPMC) is a rare histologic form of estrogen receptor (ER)-positive invasive carcinoma, characterized by micropapillary clusters of tumor cells in lakes of extracellular mucin. We sought to determine the genetic alterations underpinning MPMCs, and to define whether they overlap with those from mucinous carcinomas and/or invasive micropapillary carcinomas.

Methods And Results: DNA from five MPMCs was subjected to whole-exome sequencing. Read More

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http://dx.doi.org/10.1111/his.13853DOI Listing

Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinomas.

Histopathology 2019 Mar 7. Epub 2019 Mar 7.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Aim: Polymorphous adenocarcinoma (PAC) usually follows an indolent course, but some cases may display recurrences and high-grade features. The genetic events associated with recurrences and high-grade versions are yet to be defined. Our aim was to determine the genetic underpinning of recurrent PACs of the salivary gland and the repertoire of somatic genetic alterations in cases with high-grade histology. Read More

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http://dx.doi.org/10.1111/his.13854DOI Listing
March 2019
2 Reads

Eutrophication in histopathology.

Histopathology 2019 Mar 6. Epub 2019 Mar 6.

Faculty of Pharmacy, University of Salamanca, Campus Miguel de Unamuno. Lic. Méndez Nieto, s/n, 37007, Salamanca, Spain.

Eutrophication is the term used to define the process by which some habitats such as lakes, reservoirs, streams, or bays become overloaded with nutrient-rich water. This process can occur in both freshwater and saltwater habitats. When this occurs, large blooms of algae and aquatic plants grow as a result of an excess of nitrogen and phosphorus. Read More

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http://dx.doi.org/10.1111/his.13852DOI Listing

BRAF V600E immunohistochemistry demonstrates that some sessile serrated lesions with adenomatous dysplasia may represent collision lesions.

Histopathology 2019 Mar 2. Epub 2019 Mar 2.

Envoi Specialist Pathologists, Brisbane, QLD, Australia.

Aim: Sessile serrated lesions (SSL) with dysplasia are uncommon polyps with a high risk of rapid malignant transformation. Most of these lesions have a BRAF mutation and 75% show loss of MLH1 expression in their dysplastic component. Different morphological patterns of dysplasia occurring in these polyps have been recently described. Read More

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http://dx.doi.org/10.1111/his.13851DOI Listing

Histological Aging of Fractures in Infants: a practical algorithm for assessing infants suspected of accidental or non-accidental injury.

Histopathology 2019 Mar 1. Epub 2019 Mar 1.

School of Biological Sciences, University of Manchester.

This study is the first to systematically document histological features of fractures of known age in infants (≦12 months). It has been used to develop a tabulated database specifically to guide histopathologists to age fractures in children considered to have suffered accidental or non-accidental injury (NAI). Currently in the UK there are insufficient pathologists with experience in histological aging of fractures to meet the medicolegal need for this examination. Read More

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http://dx.doi.org/10.1111/his.13850DOI Listing

Integrated phenotype-genotype approach in diagnosis and classification of common CNS tumours.

Histopathology 2019 Mar 1. Epub 2019 Mar 1.

Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT.

After nearly a century of histological classification of Central Nervous System tumours, the 2016 revised WHO classification has incorporated molecular features with clinical and prognostic relevance into brain tumour classification. In this review, we discuss the latest integrated phenotype-genotype approach to the most common intrinsic brain tumours in adults and children. The key genetic mutations and abnormalities, essential to the definition of these tumours in line with the current WHO classification are described. Read More

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http://dx.doi.org/10.1111/his.13849DOI Listing

Clinico-pathological factors associated with BRAF-V600E mutation in colorectal serrated adenomas.

Histopathology 2019 Feb 27. Epub 2019 Feb 27.

Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Background: Serrated adenomas are genetically heterogeneous, and the histological classification into sessile serrated (SSA) adenoma and traditional serrated adenoma (TSA) does not reflect the molecular landscape.

Objective: To assess clinical or pathological factors associated with BRAF-V600E mutation in serrated adenomas.

Methods: Systematic review and meta-analysis was performed by searching electronic databases from January 2011 to January 2019 for studies assessing the association of BRAF-V600E mutation with clinical or pathological features of serrated adenomas. Read More

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http://dx.doi.org/10.1111/his.13846DOI Listing
February 2019

Three-dimensional architecture of common benign and pre-cancerous prostate epithelial lesions.

Histopathology 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

Aim: Many glandular lesions can mimic prostate cancer microscopically including atrophic glands, adenosis and prostate intraepithelial neoplasia. While the characteristic histopathological and immunohistochemical features of these lesions have been well established, little is known about their three-dimensional architecture. Our objective was to evaluate the three-dimensional organization of common prostate epithelial lesions. Read More

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http://dx.doi.org/10.1111/his.13848DOI Listing
February 2019

Transferrin receptor 1 overexpression is associated with tumor dedifferentiation and acts as a potential prognostic indicator of hepatocellular carcinoma.

Histopathology 2019 Feb 27. Epub 2019 Feb 27.

Departments of Pathology & Microbiology, Faculty of Medicine, Saga University.

Aim: Hepatocellular carcinoma (HCC) is the second leading cause of cancer mortality worldwide. An excess of iron in liver tissue causes oxidative stress, leading to hepatocellular carcinogenesis. Iron metabolism, which is regulated by a complex mechanism, is important for cancer cell survival. Read More

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http://dx.doi.org/10.1111/his.13847DOI Listing
February 2019
1 Read

Impact of pre-analytic variables on deep learning accuracy in histopathology.

Histopathology 2019 Feb 22. Epub 2019 Feb 22.

University of California Davis Health, Department of Pathology & Laboratory Medicine.

Aims: Machine Learning (ML) binary classification in diagnostic histopathology is an area of intense investigation. Several assumptions, including training image quality/format and the number of training images required, appear similar in many studies irrespective of the paucity of supporting evidence.

Methods: We empirically compared training image file type, training set size, and two common Convolutional Neural Networks (CNN) using transfer learning (ResNet50, SqueezeNet). Read More

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http://dx.doi.org/10.1111/his.13844DOI Listing
February 2019
5 Reads

Immunohistochemistry Using a Pan-TRK Antibody Distinguishes Secretory Carcinoma of Salivary Gland from Acinic Cell Carcinoma.

Histopathology 2019 Feb 23. Epub 2019 Feb 23.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Aims: Secretory carcinoma (previously known as mammary analog secretory carcinoma) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors, secretory carcinoma can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK antibody shows promise for identifying tumors with NTRK fusions. Read More

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http://dx.doi.org/10.1111/his.13845DOI Listing
February 2019

Massively Parallel Sequencing Analysis of Benign Melanocytic Nevi.

Histopathology 2019 Feb 21. Epub 2019 Feb 21.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Aims: Melanocytic nevi are benign lesions of the skin or mucosa, which may constitute non-obligate precursors of malignant melanoma, particularly when displaying lentiginous and dysplastic features. Here we sought to interrogate the repertoire of somatic genetic alterations in melanocytic nevi.

Methods And Results: DNA extracted from 12 melanocytic nevi and matching normal tissue were separately microdissected and subjected to targeted massively parallel sequencing targeting ≥300 cancer genes. Read More

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http://dx.doi.org/10.1111/his.13843DOI Listing
February 2019

ALK Expression in Small Cell Lung Cancer.

Histopathology 2019 Feb 20. Epub 2019 Feb 20.

Dept of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.

Introduction: ALK immunohistochemistry has shifted from a screening tool to a sole determinant for ALK-targeted therapy. Recent articles have referred to SCLC transformation as a resistance mechanism after ALK inhibitor treatments, but few reports have addressed ALK expression in treatment-naïve SCLC in a comprehensive manner.

Methods: We examined ALK expression in a consecutive series of SCLC tumors, and the expression mechanism was analyzed regarding gene rearrangement, copy number changes, and point mutations. Read More

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http://dx.doi.org/10.1111/his.13842DOI Listing
February 2019

Spindle cell tumour with S100 and CD34 co-expression showing PDZRN3-RAF1 rearrangement - a recently described entity.

Histopathology 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore, 119074.

Spindle cell tumours with S100 and CD34 co-expression (without SOX-10 positivity) have been recently collated into an entity showing recurrent fusions involving RAF1, BRAF and NTRK1/2 genes . These tumours exhibit a spectrum of morphological characteristics ranging from benign to malignant . Recurring histological features include monomorphic spindle cell proliferation, stromal hyalinization and perivascular keloidal collagen . Read More

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http://dx.doi.org/10.1111/his.13841DOI Listing
February 2019
1 Read

Significance of bronchiolocentric fibrosis in patients with histopathologic usual interstitial pneumonia.

Histopathology 2019 Feb 11. Epub 2019 Feb 11.

Department of Pathology, University of California San Francisco, San Francisco, California, USA.

Aims: To evaluate the clinical significance of bronchiolocentric fibrosis in patients with a histopathologic pattern of usual interstitial pneumonia.

Methods And Results: Two hundred fifty-two patients with pathological usual interstitial pneumonia pattern were identified. Two hundred fifteen of these patients (215/252) had the multidisciplinary diagnosis of idiopathic pulmonary fibrosis. Read More

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http://dx.doi.org/10.1111/his.13840DOI Listing
February 2019
2 Reads

Gene fusion involving the insulin-like growth factor 1 receptor in an ALK-negative inflammatory myofibroblastic tumour.

Histopathology 2019 Feb 8. Epub 2019 Feb 8.

Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.

Inflammatory myofibroblastic tumour (IMT) is a soft tissue tumour primarily affecting children and young adults. Approximately 50% of IMTs have gene fusions involving the receptor tyrosine kinase (RTK)-encoding ALK gene, providing a molecular rationale for treating IMT patients with unresectable tumours with tyrosine kinase inhibitors (TKI). However, a subset of IMT instead displays fusions affecting other RTK-encoding genes, so far including NTRK3, PDGFRB, and ROS1. Read More

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http://doi.wiley.com/10.1111/his.13839
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http://dx.doi.org/10.1111/his.13839DOI Listing
February 2019
11 Reads

Tumour Parcellation and Quantification (TuPaQ): a tool for refining biomarker analysis through rapid and automated segmentation of tumour epithelium.

Histopathology 2019 Feb 8. Epub 2019 Feb 8.

Nottingham Molecular Pathology Node and Academic Unit of Pathology, Division of Cancer and Stem Cells, University of Nottingham, Queen's Medical Centre, Nottingham, UK.

Background And Aims: Immunohistochemistry (IHC) is an essential component of biomarker research in cancer. Automated biomarker quantification is hampered by the failure of computational algorithms to discriminate "negative" tumour cells from "negative" stromal cells. We sought to develop an algorithm for segmentation of tumour epithelium in colorectal cancer (CRC) irrespective of the biomarker expression in the cells. Read More

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http://dx.doi.org/10.1111/his.13838DOI Listing
February 2019

Behaviour and characteristics of low-grade ductal carcinoma in situ of the breast: literature review and single centre retrospective series.

Histopathology 2019 Feb 7. Epub 2019 Feb 7.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Diagnostics Tower, Singapore, 169856.

Aims: Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous disease that has risen to prominence and more recently controversy, with the advent of screening mammography. Debate about the true biological potential of low nuclear grade DCIS continues to challenge therapeutic considerations. In this study, we carried out a comprehensive literature review of the behaviour, outcomes and current management trials of low-grade DCIS, as well as a retrospective study of a large single institutional series of low-grade DCIS diagnosed at our hospital. Read More

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http://dx.doi.org/10.1111/his.13837DOI Listing
February 2019
4 Reads

A Case of EBV-Associated Blastic Lymphoplasmacytic Proliferation in an Esophageal Ulcer with a Self-Limiting Course: Overlapping Lesion between EBV Mucocutaneous Ulcer and Polymorphic Lymphoplasmacytic Disorder.

Histopathology 2019 Feb 6. Epub 2019 Feb 6.

Division of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami and, Sylvester Comprehensive Cancer Center, Miami, FL.

B cell lymphoproliferative disorders (LPD) of varied malignant potential occur in association with immunodeficiency and include among others, follicular hyperplasia, infectious mononucleosis-like hyperplasia, plasmacytic hyperplasia, polymorphic B-lymphoproliferative disorders and the recently described clinicopathologic entity named as EBV-positive mucocutaneous ulcer (EBV-MCU). EBV-MCU is a localized and usually self-limited EBV-associated LPD characterized by a circumscribed ulcer involving oropharyngeal mucosa, skin, or gastrointestinal tract reported most often in elderly patients with presumed age-associated immunodeficiency. Histologically, EBV-MCU is characterized by a polymorphous infiltrate, which frequently includes atypical large B cells with Hodgkin/Reed-Sternberg (HRS) like cells admixed with abundant reactive T cells usually forming a rim around the base of the lesion. Read More

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http://dx.doi.org/10.1111/his.13836DOI Listing
February 2019
1 Read

Decrease of variation in the grading of dysplasia in colorectal adenomas with a national e-learning module.

Histopathology 2019 Feb 6. Epub 2019 Feb 6.

Foundation PALGA (the nationwide network and registry of histo- and cytopathology in the Netherlands), Houten, the Netherlands.

Aims: Variation in health care is undesirable since this is potentially harmful for patients. In the Netherlands, an e-learning module was developed to standardise pathologic evaluation of colorectal adenomas. We studied the effect of e-learning on interlaboratory variability in grading of dysplasia in screened conventional colorectal adenomas. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13834
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http://dx.doi.org/10.1111/his.13834DOI Listing
February 2019
4 Reads

The prognostic significance of lysosomal protective protein (Cathepsin A) in breast ductal carcinoma in situ.

Histopathology 2019 Feb 6. Epub 2019 Feb 6.

Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, The University of Nottingham, Nottingham City Hospital, UK.

Background: Cathepsin A (CTSA) is a key regulatory enzyme for galactoside metabolism. Additionally, it has a distinct proteolytic activity and plays a role in tumour progression. CTSA is differentially expressed at the mRNA level between breast ductal carcinoma in situ (DCIS) and invasive breast carcinoma (IBC). Read More

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http://dx.doi.org/10.1111/his.13835DOI Listing
February 2019
5 Reads
3.453 Impact Factor

Prostate cancer with comedonecrosis is frequently, but not exclusively, intraductal carcinoma: a need for reappraisal of grading criteria.

Histopathology 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, USA.

Aims: Comedonecrosis in prostate cancer has always been Gleason pattern 5. However, we aimed to evaluate how intraductal carcinoma (not graded) with comedonecrosis should be considered.

Methods And Results: From 52 radical prostatectomy patients, 40 were informative and evaluated with immunohistochemistry for basal cells. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13833
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http://dx.doi.org/10.1111/his.13833DOI Listing
February 2019
2 Reads

Primary Cutaneous Large B-Cell Lymphomas: relevance of the 2017 WHO Classification.

Histopathology 2019 Feb 4. Epub 2019 Feb 4.

Pathology Department, University Hospital of Bordeaux, Hôpital Haut-Lévêque, 33604, Bordeaux Cedex, France.

Aims: We applied the 2017 WHO classification criteria to categorize a series of 64 primary cutaneous large B-cell lymphomas (PCLBCLs), containing a majority (⩾80%) of large-cells and a proliferative rate ⩾40%, raising the problem of the differential diagnosis between PCLBCLs, leg type (PCLBCLs-LT) or primary cutaneous follicle center lymphomas with large cell morphology (PCFCLs-LC). The aims were to determine reproducibility and prognostic relevance of the 2017 WHO criteria.

Methods And Results: Morphology and phenotype identified 32 PCLBCLs-LT and 25 PCFCLs-LC; 7 cases (11%) remained unclassified. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13832
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http://dx.doi.org/10.1111/his.13832DOI Listing
February 2019
7 Reads

Distribution of emphysema and fibrosis in idiopathic pulmonary fibrosis with coexisting emphysema.

Histopathology 2019 Feb 4. Epub 2019 Feb 4.

Department of Pathology, Fukuoka University School of Medicine and Hospital.

Aims: Combined pulmonary fibrosis and emphysema (CPFE) is a syndrome that results from tobacco smoking. Emphysema and fibrosis in CPFE patients have been considered to exist separately, with emphysema in the upper lobes and interstitial pneumonia in the lower lobes. The aim of this study was to examine the intrapulmonary distribution of fibrosis and emphysema in clinically diagnosed patients with idiopathic pulmonary fibrosis (IPF) having coexisting emphysema. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/his.13831
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http://dx.doi.org/10.1111/his.13831DOI Listing
February 2019
6 Reads

Differential clinical impacts of tumour budding evaluated by immunohistochemical and haematoxylin and eosin staining in stage II colorectal cancer.

Histopathology 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgery, National Defense Medical College.

Aim: The aim of this study was to clarify the quantitative and qualitative differences of tumour budding identification between haematoxylin and eosin (H&E) and immunohistochemical staining for cytokeratin and to estimate the respective clinical impacts in stage II colorectal cancer.

Methods And Results: We retrospectively examined 314 surgically resected cases of stage II colorectal cancer and assessed tumour budding on serial section slides with H&E and immunohistochemical staining for cytokeratin. Tumour budding counts based on cytokeratin-stained slides were strongly correlated with those based on H&E-stained slides, having higher detection and reproducibility. Read More

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http://dx.doi.org/10.1111/his.13830DOI Listing
January 2019
1 Read

Reproducibility of the Peritoneal Regression Grading Score (PRGS) for assessment of response to therapy in peritoneal metastasis.

Histopathology 2019 Jan 27. Epub 2019 Jan 27.

Department of Pathology, Odense University Hospital, Odense, Denmark.

Introduction: The 4-tiered Peritoneal Regression Grading Score (PRGS) is assessing response to chemotherapy in peritoneal metastasis (PM). The PRGS is for example used to assess response to Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). However, the reproducibility of the PRGS is currently unkown. Read More

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http://dx.doi.org/10.1111/his.13829DOI Listing
January 2019

Integrating clinical, molecular, proteomic and histopathological data within the tissue context: Tissunomics.

Histopathology 2019 Jan 22. Epub 2019 Jan 22.

Translational Molecular Pathology, Vall d'Hebron Institute of Research (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.

Malignant tumors show a marked degree of morphological, molecular and proteomic heterogeneity. This variability is closely related to microenvironmental factors and the location of the tumor. The activation of genetic alterations is very tissue dependent and only few tumors have distinct genetic alterations. Read More

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http://dx.doi.org/10.1111/his.13828DOI Listing
January 2019

Impact of Tumour Budding Grade in 310 Patients Who Underwent Surgical Resection for Extrahepatic Cholangiocarcinoma.

Histopathology 2019 Jan 22. Epub 2019 Jan 22.

Department of Gastroenterological Surgery II, Hokkaido University, Faculty of Medicine, Sapporo, Japan.

Aims: Tumour budding is a risk factor for poor prognosis in various cancers. Tumour buds may present an epithelial-mesenchymal transition (EMT) morphological phenotype. This study aimed to elucidate the prognostic impact of tumour budding grade and its association with clinicopathological and EMT-related features in perihilar cholangiocarcinoma (PHCC) or distal cholangiocarcinoma (DCC). Read More

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http://dx.doi.org/10.1111/his.13827DOI Listing
January 2019

The Inverted Appendix - A Potentially Problematic Diagnosis: Clinicopathologic Analysis of 21 Cases.

Histopathology 2019 Jan 22. Epub 2019 Jan 22.

Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD, USA.

Aims: Inverted appendices are rare but have the potential to cause diagnostic confusion among endoscopists and pathologists. The aim of this study was to describe the clinicopathologic features of inverted appendices seen at our institution over the last 30 years.

Methods And Results: 21 inverted appendices were identified and the clinical and pathologic features reviewed. Read More

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http://dx.doi.org/10.1111/his.13824DOI Listing
January 2019
4 Reads

PD-L1, RB1 and mismatch repair protein immunohistochemical expression in neuroendocrine carcinoma, small cell type of the uterine cervix.

Histopathology 2019 Jan 22. Epub 2019 Jan 22.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Aim: Neuroendocrine carcinoma, small cell type of the uterine cervix (SmCC-Cx) is a rare HPV- related tumor with limited therapeutic options. Merkel cell carcinoma, another virus-associated neuroendocrine malignancy, has significant PD-L1 expression rates. PD-L1 expression has been reported in other malignancies of the cervix. Read More

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http://doi.wiley.com/10.1111/his.13825
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http://dx.doi.org/10.1111/his.13825DOI Listing
January 2019
4 Reads

Intramucosal colorectal carcinoma with lymphovascular invasion: clinicopathological characteristics of 9 cases.

Histopathology 2019 Jan 21. Epub 2019 Jan 21.

Department of Diagnostic Pathology, NTT Medical Center Tokyo, Tokyo, Japan.

Aims: Recent studies have provided the concept of invasive intramucosal colorectal carcinoma (CRC), and a case of intramucosal CRC with lymphatic invasion was reported; however, the characteristics of such cases and the risk of lymph node metastasis have never been investigated. Therefore, we aimed to assess the pathological characteristics of intramucosal CRCs with lymphovascular invasion as well as the possibility of lymph node metastasis as an indication for additional surgery.

Methods And Results: To delineate the histological features of intramucosal CRCs with lymphovascular invasion, we analyzed several histological features and compared their incidence among 9 such cases, as well as 20 other cases of intramucosal CRCs without lymphovascular invasion. Read More

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http://doi.wiley.com/10.1111/his.13826
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http://dx.doi.org/10.1111/his.13826DOI Listing
January 2019
4 Reads

Elevated Preexisting Lymphocytic Infiltration in Tumor Stroma Predicts Poor Prognosis in Resectable Urothelial Carcinoma of the Bladder.

Histopathology 2019 Jan 17. Epub 2019 Jan 17.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Aims: Lymphocytic infiltration is predominantly distributed in the tumor stroma and represents the tumor-related immune response. This study was to elucidate the prognostic value of stromal lymphocytic infiltration (SLI) in resectable urothelial carcinoma of the bladder (UCB).

Methods: The prognostic significance of SLI in UCB was assessed in a discovery (n=226; 60 deaths) cohort and a validation cohort (n=417; 103 deaths). Read More

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http://doi.wiley.com/10.1111/his.13807
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http://dx.doi.org/10.1111/his.13807DOI Listing
January 2019
12 Reads

Neoadjuvant chemoradiation for patients with advanced esophageal cancer- Which response grading system best impacts prognostic discrimination?

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Institute of Pathology, University of Cologne, Cologne, Germany.

Aim: Neoadjuvant chemoradiation reduces tumor volume and improves R0 resection rate, followed by extended survival for patients with advanced esophageal cancer. The degree of tumor regression has high prognostic relevance. To date, there is still no generally accepted tumor regression grading system. Read More

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http://dx.doi.org/10.1111/his.13811DOI Listing
January 2019
1 Read

C4d detection and histological patterns in the diagnosis of antibody-mediated rejection after lung transplantation: a single-centre study.

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Département de Pathologie, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris, France.

Aims: Antibody-mediated rejection (AMR) is an emerging and challenging issue in transplantation. Endothelial deposition of C4d and microvascular inflammation (MI) are reliable markers of AMR in renal and cardiac transplantation (Tx), but remain controversial in lung.

Methods And Results: In order to assess C4d immunohistochemistry and histological patterns for the diagnosis of lung AMR, we reviewed 158 transbronchial biopsies (TBBs) (n=85 clinically indicated, and n=73 surveillance TBBs) from 48 recipients, blindly of clinical and serological data. Read More

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http://dx.doi.org/10.1111/his.13823DOI Listing
January 2019
1 Read

Hypoxia-related carbonic anhydrase IX expression is associated with unfavourable response to first-line therapy in classical Hodgkin's lymphoma.

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Department of Pathology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Aims: The present study evaluates the impact of hypoxia-related carbonic anhydrase IX and XII isoenzyme expression as a basic adaptive mechanism to neutralise intracellular acidosis in classical Hodgkin's lymphoma (cHL).

Methods And Results: Eighty-one primary biopsies and 15 relapsed tissue samples diagnosed with cHL were analysed for necrosis, CAIX and CAXII expression and cell proliferation to compare hypoxia-related histological and functional data with survival characteristics. Variable, but highly selective cell membrane CAIX expression could be demonstrated in Hodgkin-Reed-Sternberg (HRS) cells in 39 of 81 samples (48. Read More

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http://dx.doi.org/10.1111/his.13808DOI Listing
January 2019
15 Reads

SMAD4 alteration associates with invasive-front pathological markers and poor prognosis in colorectal cancer.

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Objective: SMAD4 acts as a tumor suppressor, and the loss of SMAD4 is associated with poor prognosis in colorectal cancer (CRC). Although next-generation sequencing (NGS) enabled us to detect numerous genetic alterations in a single assay, the clinical significance of SMAD4 alteration detected with NGS has not been fully investigated. The aim of this study was to evaluate the clinicopathological characteristics and clinical significance of SMAD4 alteration detected with NGS in CRC. Read More

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http://doi.wiley.com/10.1111/his.13805
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http://dx.doi.org/10.1111/his.13805DOI Listing
January 2019
9 Reads

DNA Damage Repair Alterations are Frequent in Prostatic Adenocarcinomas with Focal Pleomorphic Giant Cell Features.

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Aims: Prostatic adenocarcinomas with focal pleomorphic giant cell features are a rare tumour subtype with abysmal clinical outcomes. More than one third of cases with this histology die within a year of the initial diagnosis of prostate cancer. Potential targeted therapies are desperately needed, however the molecular features of these tumours remain unknown. Read More

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http://doi.wiley.com/10.1111/his.13806
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http://dx.doi.org/10.1111/his.13806DOI Listing
January 2019
8 Reads

A phenotypical map of disseminated hepatocellular carcinoma suggests clonal constraints in metastatic sites.

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Liver Cancer Research Program, Division of Liver Diseases, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Aims: Access to tissue in patients with hepatocellular carcinoma (HCC) is limited compared to other malignancies, particularly at advanced stages. This has precluded a thorough characterisation of molecular drivers of HCC dissemination, particularly in relation to distant metastases. Biomarker assessment is restricted to early stages, and paired primary-metastatic comparisons between samples from the same patient are difficult. Read More

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http://dx.doi.org/10.1111/his.13809DOI Listing
January 2019
6 Reads

Molecular profiling of the biphasic components of hepatic carcinosarcoma by targeted next-generation sequencing.

Histopathology 2019 Jan 10. Epub 2019 Jan 10.

Department of Pathology, Fudan University Zhongshan Hospital, 180 Fenglin Road, Shanghai, China.

Aims: To better understand the tumor genesis and molecular features of hepatic carcinosarcoma (HCS).

Methods And Results: We presented 13 cases of HCS, including the clinicopathological and immunohistochemical features, and analyzed the molecular alterations in separately microdissected carcinomatous and sarcomatous components in 8 cases using targeted next-generation sequencing with a panel of 329 cancer related genes. As a result, transitional areas were observed between the two components of HCSs in all cases. Read More

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http://dx.doi.org/10.1111/his.13822DOI Listing
January 2019
3 Reads
3.453 Impact Factor

Detailed Pathological Analysis of the Advancing Edge of the Tumor Can Effectively Stratify Clinical T4b Colorectal Cancer Patients.

Histopathology 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Aims: Pathological staging of colorectal cancers (CRCs) that involve adhesion to adjacent organs (clinical stage T4b, cT4b) is sometimes difficult because the morphology of the invasive front varies. To resolve this issue, we reviewed 492 surgically resected CRC samples, comprising 96 cT4b tumors and, for comparison, 335 typical pathological stage (p) T3 and 61 pT4a tumors.

Methods And Results: Cases were subdivided into four groups according to the presence or absence of microscopic tumor invasion into the muscular wall of the adjacent organs and peri-tumoral abscess along invasive front. Read More

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http://dx.doi.org/10.1111/his.13820DOI Listing
January 2019
3 Reads

The expanding morphological and genetic spectra of MYOD1-mutant spindle cell/sclerosing rhabdomyosarcomas: a clinicopathological and molecular comparison of mutated and nonmutated cases.

Histopathology 2019 Jan 3. Epub 2019 Jan 3.

Department of Anatomical Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Aims: Spindle cell/sclerosing rhabdomyosarcomas (SC/SRMSs) feature spindled and/or rounded rhabdomyosarcomatous cells within variably hyalinized stroma. Only 30%-67% of SC/SRMSs harbor neomorphic MYOD1 p.L122R mutations, indicating heterogeneity in this RMS type. Read More

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http://doi.wiley.com/10.1111/his.13819
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http://dx.doi.org/10.1111/his.13819DOI Listing
January 2019
10 Reads

Handling and Reporting of Pelvic Lymphadenectomy Specimens in Prostate and Bladder Cancer: A Web-based Survey by the European Network of Uropathologists (ENUP).

Histopathology 2019 Jan 3. Epub 2019 Jan 3.

University Health Network, University of Toronto, Toronto, Canada.

Introduction: Pathologic evaluation of lymphadenectomy specimens plays a pivotal role in accurate lymph node (LN) staging. Guidelines standardizing the gross handling and reporting of pelvic LN dissection (PLND) in prostate (PCa) and bladder (BCa) cancer are currently lacking. This study aimed to establish current practice patterns of PLND evaluation among pathologists. Read More

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http://doi.wiley.com/10.1111/his.13818
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http://dx.doi.org/10.1111/his.13818DOI Listing
January 2019
3 Reads

Utility of CD123 immunohistochemistry in differentiating lupus erythematosus from cutaneous T-cell lymphoma.

Histopathology 2018 Dec 31. Epub 2018 Dec 31.

Department of Pathology, University of Michigan, Ann Arbor, MI.

Aims: Histopathologic overlap between lupus erythematosus and certain types of cutaneous T-cell lymphoma (CTCL) is well documented. CD123+ plasmacytoid dendritic cells (PDCs) are typically increased in lupus erythematosus, but have not been well studied in CTCL. We aimed to compare CD123 immunostaining and histopathologic features in these conditions. Read More

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http://dx.doi.org/10.1111/his.13817DOI Listing
December 2018
2 Reads

Upper GI biopsies for Adenocarcinoma - how many biopsies should endoscopists take?

Histopathology 2018 Dec 28. Epub 2018 Dec 28.

Dept of gastroenterology, Nottingham Digestive Diseases BRC, Nottingham University Hospitals, Nottingham, UK.

Aims: There is evidence that 4 or 5 gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to address this gap by assessing the number of biopsies required to get at least 4 viable biopsies containing cancer METHODS AND RESULTS: 105 consecutive biopsy cases of gastric and oesophageal adenocarcinoma were retrieved from file. Read More

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http://dx.doi.org/10.1111/his.13816DOI Listing
December 2018
1 Read