4,857,084 results match your criteria Histology and histopathology[Journal]


Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2018 Dec 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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December 2018
2 Reads

Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.

Biomed Pharmacother 2018 Dec 3;110:285-293. Epub 2018 Dec 3.

Department of Organ Transplantation, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

Objective: Wuzhi (WZ) capsule contains an ethanol extract of Schisandra sphenanthera. The efficacy of WZ in treating non-alcoholic fatty liver disease (NAFLD) has not yet been elucidated. The present study assessed the effects of WZ on NAFLD. Read More

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December 2018
1 Read
2.023 Impact Factor

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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November 2018
2 Reads

Beneficial Effect of Curcumin Nanoparticles-Hydrogel on Excisional Skin Wound Healing in Type-I Diabetic Rat: Histological and Immunohistochemical Studies.

Ann Anat 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt.

Management of diabetic wounds remains a major challenge in the medical field, mostly due to incompetent outcomes of treatments. Curcumin has been documented as anti-inflammatory, antioxidant, antimicrobial and antineoplastic agent in addition to wound healing activities. However, its poor aqueous solubility and impaired skin permeation handicap its topical pharmaceutical usage. Read More

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December 2018
7 Reads

Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.

Clin Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:

Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data. Read More

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December 2018
6 Reads

Lack of NWC protein (c11orf74 homolog) in murine spermatogenesis results in reduced sperm competitiveness and impaired ability to fertilize egg cells in vitro.

PLoS One 2018 6;13(12):e0208649. Epub 2018 Dec 6.

Laboratory of Molecular and Cellular Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

NWC is an uncharacterised protein containing three strongly conserved domains not found in any other known protein. Previously, we reported that the NWC protein is detected in cells in the germinal layer in murine testes (strain: C57BL/6), and its knockout results in no obvious phenotype. We determined the NWC expression pattern during spermatogenesis, and found this protein in spermatocytes and round spermatids, but not in epididymal sperm. Read More

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December 2018

Identification of uterine telocytes and their architecture in leiomyoma.

Folia Med Cracov 2018 ;58(3):89-102

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.

Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More

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January 2018
1 Read

Intra-articular injection of hydrogen sulfide decreased the progression of gonarthrosis.

Can J Physiol Pharmacol 2018 Dec 6:1-8. Epub 2018 Dec 6.

d Department of Pharmacology, University of Giresun, Giresun, Turkey.

Hydrogen sulfide (HS) is found in both the plasma and synovial fluid of patients with gonarthrosis. In the present study, we investigated whether intra-articular injection of sodium hydrosulfide (NaSH) (1 mM, 30 μL), a HS donor, might affect gonarthrosis in rats. Gonarthrosis was induced surgically in the left knees of rats and left for 6 weeks for the development of disease. Read More

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December 2018
4 Reads

Medial elbow anatomy: A paradigm shift for UCL injury prevention and management.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Anatomy, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: To improve the management outcomes and diagnostic accuracy of the ulnar collateral ligament (UCL) injury, the anatomy of the medial side of the elbow joint is necessary to be understood in terms of the periarticular surroundings rather than the specific ligaments. The aim of this study was to anatomically clarify the medial side of the elbow joint in terms of the tendinous structures and joint capsule.

Materials And Methods: We conducted a descriptive anatomical study of 23 embalmed cadaveric elbows. Read More

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December 2018

Novel NTRK3 Fusions in Fibrosarcomas of Adults.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Rare Cancer Center.

NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More

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December 2018
2 Reads

Why Does Postoperative Pancreatic Fistula Occur After Hand-sewn Parenchymal Closure and Staple Closure in Distal Pancreatectomy?

Surg Laparosc Endosc Percutan Tech 2018 Dec 4. Epub 2018 Dec 4.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.

Hand-sewing (HS) and stapling are common parenchymal closure techniques after distal pancreatectomy. However, these methods cannot completely prevent postoperative pancreatic fistula (POPF). The mechanisms of POPF formation after closure are unknown. Read More

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December 2018

High Humidity and Age-Dependent Fruit Susceptibility Promote Development of Trichothecium Black Spot on Apple.

Plant Dis 2018 Dec 6:PDIS05180734RE. Epub 2018 Dec 6.

State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi, 712100, China.

Fruit bagging is a widely used orchard practice in China. Trichothecium black spot (TBS) is a disease highly associated with the fruit bagging. In this study, we characterized in vitro factors affecting the causal agent, Trichothecium roseum, and TBS development and infection histology on field-bagged apple fruit in situ. Read More

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December 2018

The Predictive Ability of Pre-Operative Magnetic Resonance Imaging to Detect Pathological Outcomes in Prostate Cancer

Ir Med J 2018 08 13;111(7):790. Epub 2018 Aug 13.

Department of Urology, Cork University Hospital, Wilton, Cork, Ireland

Aims Accurate preoperative knowledge of tumour stage is important in preoperative planning at radical prostatectomy (RP). The aim of this study was to assess the predictive ability of multiparametric MRI for detecting pathological outcomes. Methods A retrospective review was performed of all patients who underwent RP over a 4 year period. Read More

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August 2018
2 Reads

Early-onset colorectal cancer in young individuals.

Mol Oncol 2018 Dec 6. Epub 2018 Dec 6.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, and Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge of CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Read More

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December 2018

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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December 2018
2 Reads

Cytomine: towards an open and collaborative software platform for digital pathology bridged to molecular investigations.

Proteomics Clin Appl 2018 Dec 6:e1800057. Epub 2018 Dec 6.

Department of Electrical Engineering and Computer Science, University of Liège, Liège, Belgium.

Purpose: Digital histology is being increasingly used in research and clinical applications. In parallel new tissue imaging methods (e.g. Read More

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December 2018

Role of FGF signalling in neural crest cell migration during early chick embryo development.

Zygote 2018 Dec 6:1-8. Epub 2018 Dec 6.

1Department of Histology and Embryology, International Joint Laboratory for Embryonic Development & Prenatal Medicine, Medical College,Jinan University,Guangzhou 510632,China.

SummaryFibroblast growth factor (FGF) signalling acts as one of modulators that control neural crest cell (NCC) migration, but how this is achieved is still unclear. In this study, we investigated the effects of FGF signalling on NCC migration by blocking this process. Constructs that were capable of inducing Sprouty2 (Spry2) or dominant-negative FGFR1 (Dn-FGFR1) expression were transfected into the cells making up the neural tubes. Read More

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December 2018
1 Read

Incidental Hepatic Tissue Obtained via Routine Cholecystectomy.

Int J Surg Pathol 2018 Dec 6:1066896918817374. Epub 2018 Dec 6.

2 University of California, Irvine, CA, USA.

Background: The hepatic tissue that may occupy specimens from routine cholecystectomies has yet to be studied. Our objectives were to determine the prevalence of hepatic tissue obtained at routine cholecystectomy, to determine whether such hepatic tissue can histologically withstand technical artifacts commonly associated with cholecystectomy, and to determine whether examining such hepatic tissue has diagnostic utility.

Materials And Methods: We retrospectively reviewed 50 specimens from routine cholecystectomies that were performed by surgeons who lacked knowledge of our study. Read More

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December 2018
1 Read

Potential of Exosomes for the Treatment of Stroke.

Cell Transplant 2018 Dec 6:963689718816990. Epub 2018 Dec 6.

1 Department of Anatomy, Histology and Embryology, Discipline of Neuroscience, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Stroke is the result of blockage or rupture of blood vessels in the brain and is the leading cause of death and disability in the world. Currently only a very limited number of therapeutic approaches are available for treatment of stroke patients, and the vast majority of neuroprotective agents that tested positively in pre-clinical studies failed in clinical trials. In recent years, the clinical value of the use of exosomes for stroke treatment has received widespread attention due their unique characteristics such as low immunogenicity, low toxicity and biodegradability, ability to cross the blood-brain barrier (BBB), and their important role in communication between cells. Read More

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December 2018
1 Read

Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.

Proteomics Clin Appl 2018 Dec 6:e1700168. Epub 2018 Dec 6.

University of Bremen, Bremen, Germany.

Purpose: To develop a mass spectrometry imaging (MSI) based workflow for extracting m/z values related to putative protein biomarkers and using these for reliable tumor classification.

Experimental Design: Given a list of putative breast and ovarian cancer biomarker proteins, we extracted a set of related m/z values from heterogeneous MSI datasets derived from formalin-fixed paraffin-embedded tissue material. Based on these features, a linear discriminant analysis classification model was trained to discriminate the two tumor types. Read More

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December 2018

ERBB2 mutation frequency in lobular breast cancer with pleomorphic histology or high-risk characteristics by molecular expression profiling.

Genes Chromosomes Cancer 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pathology, Hannover Medical School, Hannover, Germany.

HER2-positive breast cancer is defined by amplification or overexpression of the HER2/ERBB2 oncogene and accounts for about 15% of breast cancer (BC) cases. Somatic mutation of ERBB2 is an alternative mechanism, by which activation of HER2 signaling can occur. ERBB2 mutation has been associated with invasive lobular breast cancer (ILBC). Read More

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December 2018
1 Read

Ultra high field Imaging of Myelin Disease Models: Towards Specific Markers of Myelin Integrity?

J Comp Neurol 2018 Dec 6. Epub 2018 Dec 6.

Sorbonne Universités, UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de la Pitié Salpêtrière, Paris, France.

Specific Magnetic Resonance Imaging (MRI) markers of myelin are critical for the evaluation and development of regenerative therapies for demyelinating diseases. Several MRI methods have been developed for myelin imaging, based either on acquisition schemes or on mathematical modeling of the signal. They generally showed good sensitivity but validation for specificity towards myelin is still warranted to allow a reliable interpretation in an in vivo complex pathological environment. Read More

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December 2018

Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma.

Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.

Division of Oncology & Hematology, University of Nebraska Medical Center, Omaha, NE, USA.

Relapsed or refractory non-Hodgkin lymphomas (NHLs) often carry poor prognosis and pose management challenges. We evaluated the safety and efficacy of dasatinib, a broad-spectrum multi-kinase inhibitor in relapsed/refractory NHL with correlative genomic analysis in a Phase I/II trial. The study included 33 patients with various sub-types of NHL who had received at least one prior therapy. Read More

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December 2018
3 Reads

The effects of five types of tea solutions on epiboly process, neural and cardiovascular development, and locomotor capacity of zebrafish.

Cell Biol Toxicol 2018 Dec 5. Epub 2018 Dec 5.

Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation, Department of Histology and Embryology, School of Medicine, Nankai University, Tianjin, 300071, China.

The effects of teas on embryonic development are still known little. The objective of this study was to compare and analyze developmental effects of green tea, delicate flavor oolong tea, strong flavor oolong tea, black tea, and pu'er tea using zebrafish embryos. Embryos were exposed in tea solutions from one-cell stage; the morphology, locomotor capacity, and gene expression of embryos or larvae were analyzed. Read More

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December 2018

PREDECT Protocols for Complex 2D/3D Cultures.

Methods Mol Biol 2019 ;1888:1-20

Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.

PREDECT, a European IMI consortium, has assumed the task to generate robust 2D and 3D culture platforms. Protocols established for 2D and 3D monoculture and stromal coculture models of increasing complexity (spheroid, stirred-tank bioreactor, Matrigel- and collagen-embedded cultures) have been established between six laboratories within academia, biotech, and pharma. These models were tested using three tumor cell lines (MCF7, LNCaP, and NCI-H1437), covering three pathologies (breast, prostate, and lung), but should be readily transferable to other model systems. Read More

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January 2019
1 Read

CT imaging comparison between intraductal papillary neoplasms of the bile duct and papillary cholangiocarcinomas.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa, 920-8641, Japan.

Objectives: To identify imaging features that assist in discriminating intraductal papillary neoplasms of the bile duct (IPNBs) from papillary cholangiocarcinomas (PCCs).

Methods: This study was approved by the institutional review board. Using the recently proposed histological diagnostic criteria for biliary papillary neoplasms, IPNBs and PCCs were selected from 537 biliary neoplasms consecutively resected in a 12. Read More

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December 2018
1 Read

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis.

Endocrine 2018 Dec 5. Epub 2018 Dec 5.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background: Italian consensus for the classification and reporting of thyroid cytology has proposed to discriminate the cancer prevalence of high (Tir 3B) vs. low (Tir 3A) risk indeterminate nodules. To obtain more robust evidence on this topic, we performed a meta-analysis of the Odds Ratio (OR) of malignancy of Tir 3B vs. Read More

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December 2018
2 Reads

Nonalcoholic Fatty Liver Disease Demonstrates a Pre-fibrotic and Premalignant Molecular Signature.

Dig Dis Sci 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, University of Massachusetts Boston, Boston, USA.

Background: Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma.

Aims: In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcriptional alterations in mouse fatty liver signified risk for the development of hepatitis, cirrhosis, and/or hepatocellular carcinoma.

Methods: SAMP6 strain mice were fed a low-fat diet or high-fat diet (HFD) for 6 months. Read More

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December 2018
1 Read

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Transl Vis Sci Technol 2018 Nov 30;7(6):18. Epub 2018 Nov 30.

Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Purpose: We correlate optical coherence tomography (OCT) retinal layer thickness measurements with histology in wild-type and retinal degenerative pigs.

Methods: OCT scans were obtained using the Bioptigen Envisu R2200. In normal pigs, three eyes were imaged in vivo, and three eyes were imaged after enucleation. Read More

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November 2018
1 Read

Prognosis Analysis of Histone Deacetylases mRNA Expression in Ovarian Cancer Patients.

J Cancer 2018 11;9(23):4547-4555. Epub 2018 Nov 11.

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China.

Histone deacetylases modulate the dynamic balance of histone acetylation and deacetylation in cells, which participate in epigenetic regulations. Accumulated evidence has demonstrated that histone deacetylases are associated with angiogenesis, cell proliferation and survival in a variety of human cancers. However, the expression and distinct prognostic value of histone deacetylases in ovarian cancer have not been well elucidated. Read More

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November 2018
1 Read

TFF3 Contributes to Epithelial-Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma Cells via the MAPK/ERK Signaling Pathway.

J Cancer 2018 31;9(23):4430-4439. Epub 2018 Oct 31.

Department of Histology and Embryology, Hebei North University, Zhangjiakou, 075000, China.

Trefoil factor 3 (TFF3) was found to be overexpressed in many types of tumours. Evidence has shown that TFF3 plays an important role in tumour proliferation, migration and invasion metastasis. However, the impact of TFF3 on patients' clinicopathological characteristics and underlying mechanisms remain unknown in papillary thyroid carcinoma (PTC). Read More

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October 2018
1 Read

Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines.

J Cancer 2018 22;9(23):4413-4421. Epub 2018 Oct 22.

Department of Histology and Embryology, Poznan University of Medical Sciences, Poznań, Poland.

Low effectiveness of chemotherapy in ovarian cancer results from development of drug resistance during treatment. Topotecan (TOP) is a chemotherapeutic drug used in second-line chemotherapy of this cancer. Unfortunately, during treatment cancer can develop diverse cellular and tissue specific mechanisms of resistance to cytotoxic drugs. Read More

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October 2018

Nomogram application to predict overall and cancer-specific survival in osteosarcoma.

Cancer Manag Res 2018 8;10:5439-5450. Epub 2018 Nov 8.

Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, People's Republic of China,

Purpose: A prognostic nomogram was applied to predict survival in osteosarcoma patients.

Patients And Methods: Data collected from 2,195 osteosarcoma patients in the Surveillance, Epidemiology, and End Results (SEER) database between 1983 and 2014 were analyzed. Independent prognostic factors were identified via univariate and multivariate Cox analyses. Read More

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November 2018
2 Reads

Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone.

J Inflamm Res 2018 8;11:421-429. Epub 2018 Nov 8.

Department of Tropical, Faculty of Medicine, Tanta University, Tanta, Egypt,

Methotrexate (MTX) is a drug used in treatment of various malignancies. Unfortunately, it leads to life-threatening complications including hepatorenal toxicity. Previous studies revealed the protective effects of metformin (MET) on hepatorenal toxicity in other models in addition to its anticancer effects. Read More

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November 2018
1 Read

Association of uncoupling protein gene polymorphisms with essential hypertension in a northeastern Han Chinese population.

J Hum Hypertens 2018 Dec 5. Epub 2018 Dec 5.

Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, 161006, Heilongjiang, China.

Uncoupling proteins (UCPs) belong to the family of mitochondrial transporter proteins and mediate regulated proton leak across the inner mitochondrial membrane. The UCPs play an important role in energy homeostasis and reactive oxygen species (ROS) release, and have been established as candidate genes for obesity, diabetes and hypertension. This study examined the possible association between the single nucleotide polymorphisms (SNPs) of UCP1-3 genes and essential hypertension (EH) in a northeastern Han Chinese population. Read More

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December 2018

AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, Missouri, USA.

Adeno-associated virus-mediated (AAV-mediated) CRISPR editing is a revolutionary approach for treating inherited diseases. Sustained, often life-long mutation correction is required for treating these diseases. Unfortunately, this has never been demonstrated with AAV CRISPR therapy. Read More

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December 2018

Inflammatory Biomarkers and Clinical Judgment in the Emergency Diagnosis of Urgent Abdominal Pain.

Clin Chem 2018 Dec 5. Epub 2018 Dec 5.

Cardiovascular Research Institute Basel (CRIB), Basel, Switzerland.

Background: The early diagnosis of urgent abdominal pain (UAP) is challenging. Most causes of UAP are associated with extensive inflammation. Therefore, we hypothesized that quantifying inflammation using interleukin-6 and/or procalcitonin would provide incremental value in the emergency diagnosis of UAP. Read More

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December 2018

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2018 Dec 5. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

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December 2018

Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival.

Gastroenterology 2018 Oct 25. Epub 2018 Oct 25.

Department of Medicine, Mayo Clinic, Scottsdale, AZ. Electronic address:

Background & Aims: Acute pancreatitis (AP) of different etiologies is associated with activation of different signaling pathways in pancreatic cells, posing challenges to development of targeted therapies. We investigated whether local pancreatic hypothermia, without systemic hypothermia, can reduce severity of AP, induced by different methods in rats.

Methods: A urethane balloon, with two polyurethane tubes was placed inside the stomach of the rats. Read More

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October 2018

[Treatment algorithm for non-melanoma skin cancer].

Ugeskr Laeger 2018 Nov;180(48)

Non-melanoma skin cancers are the most common malignant neoplasms in Denmark. The majority of cases are basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). The choice of treatment depends on tumour, area, histology and patient-specific factors. Read More

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November 2018

The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.

J Exp Clin Cancer Res 2018 Dec 5;37(1):303. Epub 2018 Dec 5.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, People's Republic of China.

Background: We and others have previously shown that the STAT3 signaling pathway is activated in some esophageal squamous cell carcinoma (ESCC) cells and is required for the survival and growth of these primary ESCC-derived xenografts. It has also been shown that the natural polyphenol curcumin is an effective anti-tumor agent.

Methods: Luciferase assay and immunoblotting were performed to examine whether curcumin suppressed STAT3 signaling. Read More

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December 2018

Quantity and quality of nucleic acids extracted from archival formalin fixed paraffin embedded prostate biopsies.

BMC Med Res Methodol 2018 Dec 5;18(1):161. Epub 2018 Dec 5.

Department of Medicine Solna, Karolinska Institute, and Department of Urology, Karolinska University Hospital, Stockholm, Sweden.

Background: In Sweden, human tissue samples obtained from diagnostic and surgical procedures have for decades been routinely stored in a formalin-fixed, paraffin-embedded, form. Through linkage with nationwide registers, these samples are available for molecular studies to identify biomarkers predicting mortality even in slow-progressing prostate cancer. However, tissue fixation causes modifications of nucleic acids, making it challenging to extract high-quality nucleic acids from formalin fixated tissues. Read More

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December 2018
1 Read

Comparative Effects of Estrogen and Phytoestrogen, Genistein on Testicular Activities of Streptozotocin-Induced Type 2 Diabetic Mice.

Reprod Sci 2018 Dec 5:1933719118815576. Epub 2018 Dec 5.

3 Department of Zoology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

The aim of this study was to compare the effect of synthetic estrogen (E2) with a phytoestrogen and genistein in ameliorating type 2 diabetes mellitus (T2D)-mediated testicular dysfunction in mice. The streptozotocin (STZ)-induced type 2 diabetic mice were treated exogenously with either E2 or genistein for 2 durations and compared their effects on testicular activities, serum glucose, and insulin level. Type 2 diabetic mice treated with E2 for only short term (14 days) improved regressive changes in the testicular histology by increasing testosterone synthesis and improving insulin sensitivity, whereas those treated for longer duration (28 days) failed to improve testicular dysfunctions. Read More

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December 2018

The Role of Tumor Necrosis Factor α in the Biology of Uterine Fibroids and the Related Symptoms.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

First Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-004 Warsaw, Poland.

Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. The incidence of UFs has been estimated at 25⁻80% depending on selected population. The pathophysiology of UFs remains poorly understood. Read More

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December 2018
1 Read

LOW-LEVEL LIGHT-ASSISTED PHOTODYNAMIC THERAPY USING A WEARABLE CAP-LIKE DEVICE FOR THE TREATMENT OF ACTINIC KERATOSIS OF THE SCALP.

Photodiagnosis Photodyn Ther 2018 Nov 30. Epub 2018 Nov 30.

Dermatology Department, Ramón y Cajal Hospital, Madrid, Spain. Electronic address:

Background: Daylight photodynamic therapy (dlPDT) is a painless and increasingly cost-effective treatment for actinic keratosis (AK). New protocols avoid incubation minimizing pain and adverse events. However, it is time-consuming and dependent on specific weather conditions. Read More

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November 2018

Spawning performance, serum sex steroids, and ovarian histology in wild-caught Levantine scraper, Capoeta damascina (Valenciennes, 1842) treated with various doses of sGnRHa + domperidone.

J Anim Sci 2018 Dec;96(12):5253-5264

School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL.

As global aquaculture continues to expand, increasing efforts are focusing on assisted reproductive technologies. This study sought to test whether salmon GnRH [D-Arg6, Pro9NEt]) analogue (sGnRHa) + domperidone injection at 0.25 mL/body weight (BW; 5-μg sGnRHa + 2. Read More

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December 2018

T4 extension alone is more predictive of better survival than a tumour size >7 cm for resected T4N0-1M0 non-small-cell lung cancer.

Eur J Cardiothorac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.

Objectives: T4N0-1 non-small-cell lung cancer (NSCLC) was historically considered curable but now includes tumours of size >7 cm according to the 8th edition tumour, node and metastasis (TNM) staging. This study was set out to evaluate the role of surgery and predictors of long-term survival after surgery in this renewed group of patients.

Methods: Patients, with clinical T4N0-2M0 NSCLC diagnosed in 2010-2013, in the National Cancer Database were queried. Read More

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November 2018

A Mouse Distraction Osteogenesis Model.

J Vis Exp 2018 Nov 14(141). Epub 2018 Nov 14.

Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine.

Distraction osteogenesis (DO) is a surgical procedure that involves skeletal tissue regeneration without cell transplantation. A DO model consists of the following three phases: the latency phase after osteotomy and placement of the external distractor; the distraction phase, wherein the separated bone ends are gradually and continuously distracted; and the consolidation phase. This custom-made distractor used for DO is comprised of two incomplete acrylic resin rings and an expansion screw. Read More

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November 2018

Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Clin Orthop Relat Res 2018 Nov 29. Epub 2018 Nov 29.

F. Schmaranzer, E. F. Liechti, M. Tannast, Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland L. Arendt, K. Nuss, B. von Rechenberg, M. Tannast, Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland P. R. Kircher, Department of Small Animals, Division of Diagnostic Imaging, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.

Background: Biochemical MRI of hip cartilage such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping is increasingly used to judge cartilage quality in the assessment of femoroacetabular impingement (FAI). The current evidence is sparse about which of these techniques yields a stronger correlation with histologic cartilage degeneration because of the difficulty in validating biochemical MRI techniques against histology in the clinical setting. Recently, an experimental ovine FAI model was established that induces chondrolabral damage and offers a validated platform to address these limitations. Read More

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November 2018
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