3,986 results match your criteria Histology and histopathology[Journal]


Differential severity of LPS-induced lung injury in CD26/DPP4 positive and deficient F344 rats.

Histol Histopathol 2019 Apr 12:18117. Epub 2019 Apr 12.

Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.

Background: Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻) Fischer (F) 344 rats suffering from a transport block in the rER caused by a point mutation showed reduced pulmonary inflammation and reduced expression of immunomodulating surfactant proteins (SP). Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18117.htm
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http://dx.doi.org/10.14670/HH-18-117DOI Listing
April 2019
1 Read

Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.

Histol Histopathol 2019 Apr 11:18116. Epub 2019 Apr 11.

Department of Clinical and Experimental Medicine, Section of Occupational Medicine, University of Catania, Catania, Italy.

To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers' skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were studied by immunohistochemistry. Morphometric and densitometric analyses were also conducted. Read More

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http://dx.doi.org/10.14670/HH-18-116DOI Listing
April 2019
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A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node.

Histol Histopathol 2019 Apr 10:18115. Epub 2019 Apr 10.

Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, England, UK.

Background- Functional properties of the sinoatrial node (SAN) are known to differ between sexes. Women have higher resting and intrinsic heart rates. Sex determines the risk of developing certain arrhythmias such as sick sinus syndrome, which occur more often in women. Read More

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http://dx.doi.org/10.14670/HH-18-115DOI Listing
April 2019
2 Reads

Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas.

Histol Histopathol 2019 Apr 9:18114. Epub 2019 Apr 9.

Department of Pathology, Yokohama City University Graduate School of Medicine, Fukuura, Kanazawa-ku, Yokohama, Japan.

In order to clarify idiopathic interstitial pneumonia (IIP)-associated lung adenocarcinoma (LADC), we herein focused on the expression profiles of mucin proteins, the most common cellular differentiation markers. The expression of the mucin (MUC) 1, MUC2, MUC3B, MUC4, MUC5AC, MUC5B, MUC6, MUC7, MUC9, and MUC21 proteins was examined immunohistochemically and their levels were semi-quantified in 80 IIP-associated LADCs and 106 non-IIP LADCs. LADCs were divided into low and high expressers based on thresholds obtained from the receiver operating characteristic (ROC) curves of each mucin protein. Read More

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http://dx.doi.org/10.14670/HH-18-114DOI Listing
April 2019
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Modulatory effect of inulin with soya isoflavones on plasma lipid profile and liver SCD-18 index in rats with induced type-2 diabetes mellitus.

Histol Histopathol 2019 Apr 8:18113. Epub 2019 Apr 8.

Department of Histology and Embryology, Pomeranian Medical University, Szczecin, Poland.

Obesity and type-2 diabetes are often associated with nonalcoholic fatty liver disease (NAFLD). Soya isoflavones act as antidiabetic agents and protect against NAFLD. There are data suggesting that inulin may increase the plasma concentration and effect of soya isoflavones. Read More

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http://dx.doi.org/10.14670/HH-18-113DOI Listing
April 2019
4 Reads

Comparison of protocols for removal of melanin from genomic DNA to optimize PCR amplification of DNA purified from highly pigmented lesions.

Histol Histopathol 2019 Apr 5:18112. Epub 2019 Apr 5.

Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.

Melanin is produced by melanocytes and protects against DNA damage by ultraviolet light. Unfortunately, the melanin protein present in melanoma tumor cells is often co-purified during DNA extraction, and this contamination may inhibit subsequent PCR methods, which directly impacts research applications and the molecular diagnostic tests needed for targeted therapeutics. There are presently no described purification protocols that efficiently remove melanin from genomic DNA. Read More

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http://dx.doi.org/10.14670/HH-18-112DOI Listing

Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma.

Histol Histopathol 2019 Apr 4:18111. Epub 2019 Apr 4.

Universidad Central del Caribe (UCC), School of Medicine, USA.

Amyloid beta (Aβ) peptides have been implicated in both Alzheimer's disease (AD) and glaucoma and have been shown to be the key etiological factor in these dangerous health complications. On the other hand, it is well known that Aβ peptide can be generated from its precursor protein and massively released from the blood to nearby tissue upon the activation of platelets due to their involvement in innate immunity and inflammation processes. Here we review evidence about the development of AD and glaucoma neuronal damage showing their dependence on platelet count and activation. Read More

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http://dx.doi.org/10.14670/HH-18-111DOI Listing
April 2019
2.096 Impact Factor

Adult-onset Alexander disease with a heterozygous D128N GFAP mutation: a pathological study.

Histol Histopathol 2019 Apr 3:18110. Epub 2019 Apr 3.

Department of Radiology. Hospital Group San Roque, Las Palmas de Gran Canaria, Spain.

The various forms of Alexander disease (AD) have been linked to heterozygous point mutations in the coding region of the HUMAN GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) gene. The aim of this study was to confirm and characterise an adult variant of AD based on the presence of Rosenthal fibres, which were identified at brain autopsy. We performed histological and immunohistochemical studies and mutation screening by cycle sequencing of exons 1, 4, 6, and 8. Read More

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http://dx.doi.org/10.14670/HH-18-110DOI Listing
April 2019
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Density of CD8-positive tumor-infiltrating T-lymphocytes is an independent prognostic factor in adenocarcinoma of the esophagogastric junction.

Histol Histopathol 2019 Apr 2:18109. Epub 2019 Apr 2.

Department of Pathology, Marienkrankenhaus Hamburg, Hamburg, Germany.

Tumor-infiltrating lymphocytes (TILs) have commonly been associated with markedly improved prognosis in a variety of human cancers, including carcinomas of the upper and lower gastrointestinal tract. Especially the presence of T-cells (cytotoxic as well as helper cells) seems to define a subgroup of patients with prolonged overall and event-free survival. The density of TILs was assessed via immunohistochemistry for CD8 and CD103 in a population of 228 adenocarcinomas of the esophagogastric junction. Read More

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http://dx.doi.org/10.14670/HH-18-109DOI Listing
April 2019
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Atelo-collagen type I bovine bone substitute and membrane in guided bone regeneration: A series of clinical cases and histopathological assessments.

Histol Histopathol 2019 Apr 1:18108. Epub 2019 Apr 1.

Department of Periodontology, University of Bern, Switzerland.

Absorbable atelo-collagen type 1 represents a new approach for guided bone regeneration with several reported advantages such as: osteoblast attachment, proliferation, mineralization potential, absorption of growth factors and inhibition of bacterial pathogen colonization. The aim of this study was to assess the clinical, radiological (preoperative width, re-entry width, gain), Periotest measurements and histologic benefits of atelo-collagen-derived bovine bone grafts (ImploBone) in combination with an atelo-collagen type I barrier membrane (ImploSorb) for guided bone regeneration (GBR) of atrophic alveolar crest in thirteen patients. Eleven patients underwent simultaneous GBR with implant insertion, two had initial GBR procedure followed by implant placement after 6 months of healing. Read More

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http://dx.doi.org/10.14670/HH-18-108DOI Listing
April 2019
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Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis.

Histol Histopathol 2019 Mar 29:18107. Epub 2019 Mar 29.

Department of Orthopedic Surgery, Osaka Medical College, Japan.

The expression of heparan sulfate endosulfatases (Sulfs) was investigated in the intervertebral disc (IVD) to clarify their role in IVD homeostasis. Sulf-1 and -2 expression were elucidated in normal and degenerated human IVD. Age-related effects on Sulf expression, type II collagen levels, and structural changes were analyzed in IVDs of wild-type (WT) and Sulf-1 knockout (Sulf-1⁻/⁻) mice. Read More

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http://dx.doi.org/10.14670/HH-18-107DOI Listing

Effects of a probiotic on the morphology and mucin composition of pig intestine.

Histol Histopathol 2019 Mar 27:18106. Epub 2019 Mar 27.

Section of Veterinary Clinics and Animal Productions, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, Valenzano (Ba), Italy.

Although the use of probiotics in human and animal medicine is growing, their mode of action remains poorly understood. This study examined the effects of a multi-strain probiotic (SLAB51™) on the morphology and carbohydrate composition of mucins secreted by goblet cells of intestinal crypts in growing-finishing pigs. Sections of duodenum, caecum and colon from pigs fed for 12 weeks with an orally administered control basal diet (No-Pro) or one with a probiotic blend (Pro) were processed for microscopic analysis and stained with (1) haematoxylin-eosin for structural and morphometrical investigation; (2) conventional histochemistry (periodic acid-Schiff, Alcian Blue pH 2. Read More

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http://dx.doi.org/10.14670/HH-18-106DOI Listing

Transcription regulators are transiently expressed during the prostate gland adaptation to the hypoandrogenic environment.

Histol Histopathol 2019 Mar 26:18105. Epub 2019 Mar 26.

Department of Structural and Functional Biology, Institute of Biology, Institute of Physics Gleb Wataghin, State University of Campinas (UNICAMP), Campinas SP, Brazil.

The high incidence of prostatic diseases, including malignant tumors, makes the understanding of prostate biology very important. Androgen deprivation, blockade by orchiectomy, or chemical castration causes prostate and tumor shrinkage. The gene networks involved in a cell type-specific fashion are rather unknown. Read More

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http://dx.doi.org/10.14670/HH-18-105DOI Listing

Implications on pathogenesis and risk of oral lichen planus neoplastic transformation: an ex-vivo retrospective immunohistochemical study.

Histol Histopathol 2019 Mar 25:18104. Epub 2019 Mar 25.

Pathology Unit, Ospedale "Sant'Andrea", DiMeT, UPO, Vercelli, Italy.

Aims: to evaluate OPN, MCM7, Ki-67, p53, Bcl-2 and 53BP1 presence, together with the abnormal adaptive CD4 and CD8 T-cell response markers expression in a series of oral lichen planus (OLP) affected patients and assess their combined contribution for a more objective disease classification.

Methods And Results: In this ex-vivo retrospective analysis, biopsy specimens from 28 adults with a clinical diagnosis of OLP at different progression degree (16 reticular, 2 plaque-like, 1 erosive and 9 mixed type) were collected. Sections were immunohistochemically investigated for the proinflammatory cytokine osteopontin (OPN), alpha-beta CD4 and CD8 positive T cells, DNA replication licensing factor (MCM7), proliferating cell marker (Ki-67), apoptotic and tumor antigen (p53), apoptosis modulator (Bcl-2) and cellular response regulator to double-strand breaks tumor suppressor p53-binding protein 1 expression. Read More

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http://dx.doi.org/10.14670/HH-18-104DOI Listing
March 2019
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Therapeutic effects of herbal compounds in cerebral ischemia with special reference to suppression of microglia activation implicated in neurodegeneration.

Histol Histopathol 2019 Mar 22:18103. Epub 2019 Mar 22.

Department of Anatomy and Histology/Embryology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, PR China.

Cerebral ischemia affects many especially with the ageing population. The ensuing ischemic reactions include oxidative stress, inflammation, and excitotoxicity among others. In the search for effective therapeutic strategies for cerebral ischemia, activated microglia which are the key player in neuroinflammation are now recognized as a potential therapeutic target. Read More

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http://dx.doi.org/10.14670/HH-18-103DOI Listing

Calcitonin gene related peptide gene-modified rat bone mesenchymal stem cells are effective seed cells in tissue engineering to repair skull defects.

Histol Histopathol 2019 Mar 21:18102. Epub 2019 Mar 21.

Shandong Provincial Key Laboratory of Dental Tissue Regeneration, School and Hospital of Stomatology, Shandong University, Jinan, Shandong, PR China.

The study is to verify whether Calcitonin gene related peptide (CGRP) gene-modified rat bone mesenchymal stem cells (BMSCs) are promising seed cells with great potential to repair bone defect. A recombinant lentiviral vector overexpressing CGRP peptide, pLenO-DCE-CGRP, was constructed and transfected into rBMSCs to obtain stable CGRP expression. Differently transfected rBMSCs: CGRP- modified rBMSCs (CGRP group), empty vector- modified rBMSCs (Vector group) and normal rBMSCs (Control group) were transferred to collagen scaffold to repair rat skull defects (n=6). Read More

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http://dx.doi.org/10.14670/HH-18-102DOI Listing

Disruption of mitochondrial homeostasis in chronic kidney disease: a mini-review.

Histol Histopathol 2019 Mar 20:18101. Epub 2019 Mar 20.

Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

Chronic kidney disease (CKD) is recognized as a worldwide health problem. Progression of CKD may lead to many serious complications, which are associated with increased morbidity and mortality. Presently, there is no satisfactory treatment. Read More

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http://dx.doi.org/10.14670/HH-18-101DOI Listing
March 2019
2.096 Impact Factor

Haptoglobin expression in human colorectal cancer.

Histol Histopathol 2019 Mar 13:18100. Epub 2019 Mar 13.

Department of Biochemistry, Genetics and Immunology, Biomedical Research Centre (CINBIO, "Centro Singular de Investigación de Galicia"), University of Vigo, Vigo (Pontevedra), Spain.

Aims and experimental design. The acute-phase protein haptoglobin (Hp) has been recently detected in colorectal cancer (CRC) tissue, where its expression correlates with metastasis. Recently, we identified Hp as a CDw75 antigen-expressing protein in colorectal tissue. Read More

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http://dx.doi.org/10.14670/HH-18-100DOI Listing

Upregulation of glucose and amino acid transporters in micropapillary carcinoma.

Histol Histopathol 2019 Mar 11:18099. Epub 2019 Mar 11.

Division of Organ Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Tottori, Japan.

Micropapillary carcinoma (MPC), a relatively rare histologic carcinoma observed in various organs, is associated with vascular invasion, nodal metastasis, and poor prognosis. MPC is different from papillary carcinoma as it has no fibrovascular core and is thus considered essentially hypovascular. MPCs are known to upregulate glucose transporter 1 (GLUT1) via the activation of a transcription factor, hypoxia-inducible factor (HIF)-1. Read More

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http://dx.doi.org/10.14670/HH-18-099DOI Listing
March 2019
5 Reads

A subpopulation of airway epithelial cells that express hepatocyte nuclear factor 4α - its implication in the development of non-terminal respiratory unit-type lung adenocarcinoma.

Histol Histopathol 2019 Mar 8:18098. Epub 2019 Mar 8.

Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

A normal counterpart and precancerous lesion that non-terminal respiratory unit (TRU) lung adenocarcinomas (LADCs) develop from have not been clarified. Non-TRU LADCs specifically express hepatocyte nuclear factor 4α (HNF4α). Thus, we have been interested in airway epithelial cells that express HNF4α as the potential precursor of non-TRU LADC. Read More

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http://dx.doi.org/10.14670/HH-18-098DOI Listing
March 2019
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Tripterygium glycoside protects diabetic kidney disease mouse serum-induced podocyte injury by upregulating autophagy and downregulating β-arrestin-1.

Histol Histopathol 2019 Mar 6:18097. Epub 2019 Mar 6.

Department of Nephrology, Zhejiang Provincial People's Hospital,Hangzhou, P.R. China.

Background: Diabetic kidney disease (DKD), one of the most common causes of end-stage renal disease(ESRD), remains prevalent in many populations. Podocyte loss and apoptosis play a crucial role in the progression of DKD. Tripterygium glycoside (TG), a widely used Chinese herb, exerted comprehensive protective effects on preventing DKD progression. Read More

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http://dx.doi.org/10.14670/HH-18-097DOI Listing
March 2019
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Epigallocatechin-3-gallate protects the testis from damage generated by experimental cryptorchidism in rabbits.

Histol Histopathol 2019 Mar 4:18096. Epub 2019 Mar 4.

Laboratory of Reproductive Biology, National Institute of Pediatrics, Mexico City, Mexico.

Cryptorchidism (CO) is a risk factor for infertility in men. It is associated with an increase in oxidative stress which alters the differentiation of the gonocytes to spermatogonia. Epigallocatechin-3-gallate (EGCG) is an antioxidant that acts as a free radical scavenger and activates the antioxidant enzymes. Read More

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http://dx.doi.org/10.14670/HH-18-096DOI Listing

Elevated blood/lymphatic vessel ratio in pterygium and its relationship with vascular endothelial growth factor (VEGF) distribution.

Histol Histopathol 2019 Mar 1:18095. Epub 2019 Mar 1.

Dept. of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares, Madrid, Spain. e-mail:

Introduction: Pterygium is a conjunctival fibrovascular tissue growth on the cornea. The pathogenesis of pterygium involves several factors such as the presence of active angiogenic factors. Expansion of the lymphatic microvasculature has also been hypothesized. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18095.htm
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http://dx.doi.org/10.14670/HH-18-095DOI Listing
March 2019
13 Reads

Eccrine spiradenoma of the nipple: Case report, differential diagnosis and literature review.

Histol Histopathol 2019 Feb 26:18094. Epub 2019 Feb 26.

Department of Medical Sciences, University of Turin, Turin, Italy.

Eccrine spiradenoma is a rare lesion originating from eccrine sweat glands, with only few cases reported in breast tissue: we here describe for the first time, an eccrine spiradenoma arising in the nipple. An 84 year-old woman with a lesion enlarging her right nipple, showing ulcerations and eczema-like changes of the covering skin, was admitted to our hospital. Surgical excision of the central quadrant with nipple-areola complex was performed, followed by histopathological evaluation which revealed an adenoma with predominantly basaloid epithelial cells. Read More

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http://dx.doi.org/10.14670/HH-18-094DOI Listing
February 2019
3 Reads

The importance of adequate recognition of normal and dysplastic myelopoiesis for the diagnosis of myelodysplastic syndromes.

Histol Histopathol 2019 Feb 19:18093. Epub 2019 Feb 19.

Escola de Citologia Hematològica Soledad Woessner-Parc de Salut Mar. Laboratorio de Citología Hematológica. Patología. GRETNHE, IMIM Hospital del Mar Research Institute, Barcelona, Spain.

The diagnosis of myelodysplastic syndromes is based on the presence of cytopenias, dysplastic morphological features on peripheral blood (PB) and bone marrow (BM), cytogenetic abnormalities and requires to rule out other diseases resembling these conditions. Optical cytomorphology is the cornerstone of diagnosis of MDS. The recognition of cytological myelodysplasia has a crucial value in diagnosis and prognosis of MDS. Read More

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http://dx.doi.org/10.14670/HH-18-093DOI Listing
February 2019
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The comparative analyses of decalcification procedures and methyl benzoate pre-treatment on tissue preservation and antigenicity in human acetabular labra.

Histol Histopathol 2019 Feb 13:18092. Epub 2019 Feb 13.

Department of Anatomy and Cell Biology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

The histological processing of musculoskeletal tissue might be challenging. The alteration of tissue composition e.g. Read More

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http://dx.doi.org/10.14670/HH-18-092DOI Listing
February 2019
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Inflammatory cytokines and antimicrobial peptides in acquired heart diseases.

Histol Histopathol 2019 Feb 8:18091. Epub 2019 Feb 8.

Pauls Stradins Clinical University Hospital, Riga, Latvia.

Introduction: One of the risk factors for cardiovascular disease is inflammation. The role that it plays in the pathogenesis of cardiovascular disease remains a topic of ongoing research. The aim of this study was to identify the appearance and distribution of inflammatory markers, interleukins 1α (Il-1α) and 10 (Il-10) and β defensins 2 (βD2), 3 (βD3), and 4 (βD4), in the right atrial tissue from different acquired heart diseases. Read More

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http://dx.doi.org/10.14670/HH-18-091DOI Listing
February 2019
2 Reads

Effects of the isoflavone daidzein in Senegalese sole, Solea senegalensis: Modulation of the oestrogen receptor-β, apoptosis and enzymatic signalling pathways.

Histol Histopathol 2019 Feb 7:18090. Epub 2019 Feb 7.

Instituto de Ciencias Marinas de Andalucía. Consejo Superior de Investigaciones Científicas. -ICMAN.CSIC- Campus Universitario Río San Pedro, Puerto Real, Cádiz, Spain.

Phytochemicals are widely present in the aquatic environment and they are derived from many anthropogenic activities. The isoflavone daidzein is a natural compound that is found in the soya products used as habitual constituents of aquafeeds. Nevertheless, this isoflavone possesses oestrogenic and apoptotic properties. Read More

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http://dx.doi.org/10.14670/HH-18-090DOI Listing
February 2019
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Polymorphous adenocarcinoma of the salivary glands: An overview of immunohistochemical features and insights on molecular pathology.

Histol Histopathol 2019 Feb 6:18089. Epub 2019 Feb 6.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Polymorphous adenocarcinoma (PAC), represents a common minor salivary gland tumor (SGT) characterized by local growth, low metastatic potential and non-aggressive biologic behavior. Due to the clinical aggressiveness noted in a subset of such tumors, the former term polymorphous low-grade adenocarcinoma (PLGA) was recently revised. PAC's clinical features and histological diversity result in clinical overlap of this entity with several other SGTs including mainly adenoid cystic carcinoma (AdCC). Read More

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http://dx.doi.org/10.14670/HH-18-089DOI Listing
February 2019
2.096 Impact Factor

Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.

Histol Histopathol 2019 Feb 1:18088. Epub 2019 Feb 1.

Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may play a crucial role in the development of CLAD, especially bronchiolitis obliterans (BO) and vasculopathy. Read More

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http://dx.doi.org/10.14670/HH-18-088DOI Listing
February 2019
1 Read

Striated-for-smooth muscle replacement in the developing mouse esophagus.

Histol Histopathol 2019 Jan 30:18087. Epub 2019 Jan 30.

Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

The esophagus is a muscular tube which transports swallowed content from the oral cavity and the pharynx to the stomach. Early in mouse development, an entire layer of the esophagus, the muscularis externa, consists of differentiated smooth muscle cells. Starting shortly after mid-gestation till about two weeks after birth, the muscularis externa almost entirely consists of striated muscle. Read More

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http://dx.doi.org/10.14670/HH-18-087DOI Listing
January 2019
1 Read

Characterization of the early pathology of cochlear stereocilia in four inbred mouse strains with progressive hearing loss.

Histol Histopathol 2019 Jan 24:18086. Epub 2019 Jan 24.

Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, Yantai, Shandong, P.R. China.

Objective: Inbred strains of mice offer promising models for understanding the genetic basis of age-related hearing loss (AHL). NOD/LtJ, A/J, DBA/2J and C57BL/6J mice are classical models of age-related hearing loss and exhibit early onset of pathology of AHL. This study was carried out to characterize the early pathology of cochlear stereocilia in the four mouse strains with age-related hearing loss. Read More

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http://dx.doi.org/10.14670/HH-18-086DOI Listing
January 2019
2 Reads

Primary extranodal vaginal non-hodgkin lymphoma: Diagnostic pitfalls and therapeutic challenges.

Histol Histopathol 2019 Jan 18:18085. Epub 2019 Jan 18.

Gynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Introduction: primary extranodal non-hodgkin vaginal lymphoma (PeNHVL) represents a rare entity, with few data published until now. We present here a series of patients with PeNHVL, analyzing our data as part of a detailed review of the available literature.

Methods: the study included a consecutive series of 6 patients with final diagnosis of PeNHVL admitted at our Institution between January 2000 and December 2017. Read More

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http://dx.doi.org/10.14670/HH-18-085DOI Listing
January 2019
3 Reads

High expression of GPNMB predicts poor prognosis in head and neck squamous cell carcinoma.

Histol Histopathol 2019 Jan 11:18084. Epub 2019 Jan 11.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Glycoprotein non-metastatic protein B (GPNMB) is a transmembrane glycoprotein that is highly expressed in several malignancies compared with its expression in matched healthy tissues. The aim of this study was to investigate the clinical characteristics and prognostic value of GPNMB expression in tumor tissue derived from a cohort of patients with head and neck squamous cell carcinoma (HNSCC). GPNMB expression in human HNSCC, oral dysplasia and normal mucosal tissue was evaluated by immunohistochemistry (IHC). Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18084.htm
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http://dx.doi.org/10.14670/HH-18-084DOI Listing
January 2019
12 Reads

Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

Histol Histopathol 2019 Jan 10:18083. Epub 2019 Jan 10.

Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot, Israel.

In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various animal models, including those of muscular dystrophies. Here, two optically active enantiomers of deoxyhalofuginone-a halofuginone analogue in which the hydroxy group in position 3 was removed from the piperidinyl entity-were evaluated with respect to their effect on muscle histopathology in mdx mice. Read More

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http://dx.doi.org/10.14670/HH-18-083DOI Listing
January 2019
2 Reads

Trehalose in ophthalmology.

Histol Histopathol 2019 Jan 9:18082. Epub 2019 Jan 9.

Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.

Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. Although trehalose is not synthesized by mammalian cells, it has recently been demonstrated to have a number of important properties that indicate its utility in humans. Read More

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http://dx.doi.org/10.14670/HH-18-082DOI Listing
January 2019
4 Reads

Roles of long-non-coding RNAs in cancer therapy through the PI3K/Akt signalling pathway.

Histol Histopathol 2019 Jan 8:18081. Epub 2019 Jan 8.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia.

The vital need for Akt in maintaining basic cellular function has highlighted its importance in carcinogenesis. Unfortunately, Akt inhibitor development outcome has remained poor, as most of them have failed to show significant clinical benefit to cancer patients during the clinical trials. Recently, a new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), which show high tissue specificity, have demonstrated great influence in cancer progression and/or cancer inhibition. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18081.htm
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http://dx.doi.org/10.14670/HH-18-081DOI Listing
January 2019
11 Reads

A brief review of chordomas: Pathogenesis, prognostic factors and therapeutic targets.

Histol Histopathol 2019 Jan 2:18080. Epub 2019 Jan 2.

Department of Orthopedics, Peking University Third Hospital, Haidian District, Beijing, P.R. China.

Chordomas are rare but locally aggressive cancer, which originate from primitive notochord remnants. Guidelines have recently been proposed to include the option of choosing chordomas in different locations. However, there is still a great challenge in the modern management of chordomas, primarily due to the high recurrence rate and poor prognosis. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18080.htm
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http://dx.doi.org/10.14670/HH-18-080DOI Listing
January 2019
15 Reads

BRAF mutation: Current and future clinical pathological applications in colorectal carcinoma.

Histol Histopathol 2018 Dec 28:18079. Epub 2018 Dec 28.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

The aims are to review the relevance of the BRAF mutations in the clinical settings of colorectal carcinoma. All the literature concerning BRAF mutations and colorectal carcinoma published in PubMed from 2010 to 2018 was reviewed. Multiple variants of BRAF mutations exist in colorectal cancer, the most common type being V600E. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18079.htm
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http://dx.doi.org/10.14670/HH-18-079DOI Listing
December 2018
18 Reads

Morphological rearrangement of the cortical region, in aging ovaries.

Histol Histopathol 2018 Dec 27:18078. Epub 2018 Dec 27.

Departament of Cellular Biology and Physiology. Institute of Biomedical Research, Universidad Nacional Autónoma de México. Mexico City.

The ovary is a structurally dynamic organ that alters with age. Modifications in the paracrine status influence the capacity of aging oocytes to develop normal embryos. Despite the importance of understanding the cellular and molecular mechanism involved in the process of ovarian aging, histological changes remain poorly understood. Read More

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http://dx.doi.org/10.14670/HH-18-078DOI Listing
December 2018
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The effect of chronic stress and obesity on sperm quality and testis histology in male rats; a morphometric and immunohistochemical study.

Histol Histopathol 2019 Mar 19;34(3):287-302. Epub 2018 Dec 19.

Department of Histology and Embryology, Medical School, Sakarya University, Sakarya, Turkey.

Objective: Stress and obesity lead structural and functional abnormalities in many organs. This research investigated the effect of these two risk factors on sperm parameters and histologic structure of testis in rat model.

Materials And Methods: Twenty-four male rats were divided into four groups with six rats in each group as control, stress, obesity, and stress-obesity groups. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18077.htm
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http://dx.doi.org/10.14670/HH-18-077DOI Listing
March 2019
12 Reads

Reduction of PGRN increased fibrosis during skin wound healing in mice.

Histol Histopathol 2018 Dec 18:18076. Epub 2018 Dec 18.

Department of Forensic Medicine, Xuzhou Medical University; Xuzhou, Jiangsu, P.R. China.

Progranulin (PGRN) is a multi-functional growth factor known to be involved in regulating of development, cell cycle progression, cell motility, tumorigenesis and angiogenesis. Research has revealed that PGRN is a crucial mediator of skin wound healing. Nonetheless, the role of PGRN in the fibrosis process of cutaneous wound healing has not been identified. Read More

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http://dx.doi.org/10.14670/HH-18-076DOI Listing
December 2018
3 Reads
2.096 Impact Factor

Safety of isotretinoin treatment as measured by liver parameters.

Histol Histopathol 2018 Dec 17:18075. Epub 2018 Dec 17.

Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas - SP, Brazil.

Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands it is often prescribed in cases of severe acne treatment. The treatment for the average patient is carried out during two to ten months. This study was designed to investigate liver structure, hepatic enzyme levels and the stress oxidative parameter after isotretinoin treatment during a similar period and using the dosages of 1 mg/kg and another one of 10 mg/kg in young male Wistar rats. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18075.htm
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http://dx.doi.org/10.14670/HH-18-075DOI Listing
December 2018
10 Reads

Histopathology of human small intestinal and colonic ischemia-reperfusion: experiences from human IR-models.

Histol Histopathol 2018 Dec 13:18074. Epub 2018 Dec 13.

NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

Intestinal ischemia-reperfusion (IR) injury is a frequent, but potentially life-threatening condition. Although much has been learned about its pathophysiology from animal IR models, the translation to the human setting is imperative for better understanding of its etiology. This could provide us with new insight into development of early detection and potential new therapeutic strategies. Read More

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http://dx.doi.org/10.14670/HH-18-074DOI Listing
December 2018
10 Reads

Parkinson's disease: a short story of 200 years.

Histol Histopathol 2018 Dec 12:18073. Epub 2018 Dec 12.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Read More

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http://dx.doi.org/10.14670/HH-18-073DOI Listing
December 2018
2 Reads

Correlation of securin and Ki67 in invasive breast carcinoma.

Histol Histopathol 2018 Dec 3:18071. Epub 2018 Dec 3.

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Aims: To identify the role of securin (PTTG) as a prognostic marker in invasive breast carcinoma and its possible relation to ki67 and to evaluate the use of ImmunoRatio® as a tool for calculating ki67 and securin labelling indices.

Methods: Securin and ki67 immunohistochemical staining were performed on tissue microarray sections representative of 118 patients diagnosed with invasive breast carcinoma from 2005 to 2011. Assessment of immunohistochemical staining was carried out using both visual counting and ImmunoRatio®. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18071.htm
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http://dx.doi.org/10.14670/HH-18-071DOI Listing
December 2018
6 Reads
2.096 Impact Factor

The distribution and time-dependent expression of HIPK2 during the repair of contused skeletal muscle in mice.

Histol Histopathol 2018 Dec 5:18072. Epub 2018 Dec 5.

Department of Forensic Pathology, China Medical University School of Forensic Medicine, Liaoning Province, PR China.

HIPK2 is an evolutionarily conserved serine/threonine kinase and is considered a co-regulator of an increasing number of transcription factors modulating a variety of cellular processes, including inflammation, proliferation and fibrosis. Skeletal muscle injuries repair is an overlapping event between inflammation and tissue repair. There are no reports about HIPK2 expression in skeletal muscles after trauma. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18072.htm
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http://dx.doi.org/10.14670/HH-18-072DOI Listing
December 2018
4 Reads

Cytokeratin expression profiles of canine epithelial tissues.

Histol Histopathol 2018 Nov 30:18070. Epub 2018 Nov 30.

Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Cytokeratins (CKs) are intermediate filaments of epithelial cells. In humans, different types of epithelia as well as their neoplasms show distinct CK expression profiles. The aim of this study was to establish a panel of CKs for the identification of specialized canine epithelia that can be integrated in a routine diagnostic setting. Read More

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http://dx.doi.org/10.14670/HH-18-070DOI Listing
November 2018
2 Reads

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Histol Histopathol 2019 Apr 27;34(4):335-352. Epub 2018 Nov 27.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

In the era of precision medicine immunohistochemistry (IHC) and immunocytochemistry (ICC) share some of the highlights in personalized treatment. Survival data obtained from clinical trials shape the cut-offs and IHC scoring that serve as recommendations for patient selection both for targeted and conventional therapies. Assessment of Estrogen and Progesterone Receptors along with HER2 status has been among the first approved immunostaining assays revolutionizing breast cancer treatment. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18069.htm
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http://dx.doi.org/10.14670/HH-18-069DOI Listing
April 2019
15 Reads

STIM promotes the epithelial-mesenchymal transition of podocytes through regulation of FcγRII activity in diabetic nephropathy.

Histol Histopathol 2018 Nov 26:18068. Epub 2018 Nov 26.

Department of Nephrology, Zhejiang Provincial People's Hospital, Zhejiang, P.R. China.

Background: Diabetic nephropathy (DN) is a serious complication in diabetic patients and has been considered as the main cause of end-stage renal disease. However, there are no studies on the role of stromal interaction molecule (STIM) and its two subtypes, STIM1 and STIM2, in the epithelial-to-mesenchymal transition (EMT) of podocytes induced by diabetic kidney disease (DKD). The present study suggests for the first time that STIM inhibition decreases DKD-induced EMT. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18068.htm
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http://dx.doi.org/10.14670/HH-18-068DOI Listing
November 2018
9 Reads