3,961 results match your criteria Histology and histopathology[Journal]


The comparative analyses of decalcification procedures and methyl benzoate pre-treatment on tissue preservation and antigenicity in human acetabular labra.

Histol Histopathol 2019 Feb 13:18092. Epub 2019 Feb 13.

Department of Anatomy and Cell Biology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

The histological processing of musculoskeletal tissue might be challenging. The alteration of tissue composition e.g. Read More

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http://dx.doi.org/10.14670/HH-18-092DOI Listing
February 2019

Inflammatory cytokines and antimicrobial peptides in acquired heart diseases.

Histol Histopathol 2019 Feb 8:18091. Epub 2019 Feb 8.

Pauls Stradins Clinical University Hospital, Riga, Latvia.

Introduction: One of the risk factors for cardiovascular disease is inflammation. The role that it plays in the pathogenesis of cardiovascular disease remains a topic of ongoing research. The aim of this study was to identify the appearance and distribution of inflammatory markers, interleukins 1α (Il-1α) and 10 (Il-10) and β defensins 2 (βD2), 3 (βD3), and 4 (βD4), in the right atrial tissue from different acquired heart diseases. Read More

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http://dx.doi.org/10.14670/HH-18-091DOI Listing
February 2019
1 Read

Effects of the isoflavone daidzein in Senegalese sole, Solea senegalensis: Modulation of the oestrogen receptor-β, apoptosis and enzymatic signalling pathways.

Histol Histopathol 2019 Feb 7:18090. Epub 2019 Feb 7.

Instituto de Ciencias Marinas de Andalucía. Consejo Superior de Investigaciones Científicas. -ICMAN.CSIC- Campus Universitario Río San Pedro, Puerto Real, Cádiz, Spain.

Phytochemicals are widely present in the aquatic environment and they are derived from many anthropogenic activities. The isoflavone daidzein is a natural compound that is found in the soya products used as habitual constituents of aquafeeds. Nevertheless, this isoflavone possesses oestrogenic and apoptotic properties. Read More

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http://dx.doi.org/10.14670/HH-18-090DOI Listing
February 2019
1 Read

Polymorphous adenocarcinoma of the salivary glands: An overview of immunohistochemical features and insights on molecular pathology.

Histol Histopathol 2019 Feb 6:18089. Epub 2019 Feb 6.

First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Polymorphous adenocarcinoma (PAC), represents a common minor salivary gland tumor (SGT) characterized by local growth, low metastatic potential and non-aggressive biologic behavior. Due to the clinical aggressiveness noted in a subset of such tumors, the former term polymorphous low-grade adenocarcinoma (PLGA) was recently revised. PAC's clinical features and histological diversity result in clinical overlap of this entity with several other SGTs including mainly adenoid cystic carcinoma (AdCC). Read More

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http://dx.doi.org/10.14670/HH-18-089DOI Listing
February 2019

Synergism of imatinib, vatalanib and everolimus in the prevention of chronic lung allograft rejection after lung transplantation (LTx) in rats.

Histol Histopathol 2019 Feb 1:18088. Epub 2019 Feb 1.

Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.

Chronic lung allograft dysfunction (CLAD) still remains a major drawback in the outcome following lung transplantation (LTx). New therapeutic strategies are warranted. Growth factors and their receptors like platelet-derived growth factor-receptor (PDGFR) and vascular endothelial growth factor-receptor (VEGFR), may play a crucial role in the development of CLAD, especially bronchiolitis obliterans (BO) and vasculopathy. Read More

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http://dx.doi.org/10.14670/HH-18-088DOI Listing
February 2019
1 Read

Striated-for-smooth muscle replacement in the developing mouse esophagus.

Histol Histopathol 2019 Jan 30:18087. Epub 2019 Jan 30.

Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

The esophagus is a muscular tube which transports swallowed content from the oral cavity and the pharynx to the stomach. Early in mouse development, an entire layer of the esophagus, the muscularis externa, consists of differentiated smooth muscle cells. Starting shortly after mid-gestation till about two weeks after birth, the muscularis externa almost entirely consists of striated muscle. Read More

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http://dx.doi.org/10.14670/HH-18-087DOI Listing
January 2019
1 Read

Characterization of the early pathology of cochlear stereocilia in four inbred mouse strains with progressive hearing loss.

Histol Histopathol 2019 Jan 24:18086. Epub 2019 Jan 24.

Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, Yantai, Shandong, P.R. China.

Objective: Inbred strains of mice offer promising models for understanding the genetic basis of age-related hearing loss (AHL). NOD/LtJ, A/J, DBA/2J and C57BL/6J mice are classical models of age-related hearing loss and exhibit early onset of pathology of AHL. This study was carried out to characterize the early pathology of cochlear stereocilia in the four mouse strains with age-related hearing loss. Read More

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http://dx.doi.org/10.14670/HH-18-086DOI Listing
January 2019
1 Read

Primary extranodal vaginal non-hodgkin lymphoma: Diagnostic pitfalls and therapeutic challenges.

Histol Histopathol 2019 Jan 18:18085. Epub 2019 Jan 18.

Gynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Introduction: primary extranodal non-hodgkin vaginal lymphoma (PeNHVL) represents a rare entity, with few data published until now. We present here a series of patients with PeNHVL, analyzing our data as part of a detailed review of the available literature.

Methods: the study included a consecutive series of 6 patients with final diagnosis of PeNHVL admitted at our Institution between January 2000 and December 2017. Read More

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http://dx.doi.org/10.14670/HH-18-085DOI Listing
January 2019
2 Reads

High expression of GPNMB predicts poor prognosis in head and neck squamous cell carcinoma.

Histol Histopathol 2019 Jan 11:18084. Epub 2019 Jan 11.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.

Glycoprotein non-metastatic protein B (GPNMB) is a transmembrane glycoprotein that is highly expressed in several malignancies compared with its expression in matched healthy tissues. The aim of this study was to investigate the clinical characteristics and prognostic value of GPNMB expression in tumor tissue derived from a cohort of patients with head and neck squamous cell carcinoma (HNSCC). GPNMB expression in human HNSCC, oral dysplasia and normal mucosal tissue was evaluated by immunohistochemistry (IHC). Read More

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http://dx.doi.org/10.14670/HH-18-084DOI Listing
January 2019
4 Reads

Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy.

Histol Histopathol 2019 Jan 10:18083. Epub 2019 Jan 10.

Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot, Israel.

In Duchenne muscular dystrophy (DMD), the progressive loss of muscle and its ability to function is associated with significant fibrosis, representing the major disease complication in patients. Halofuginone, a halogenated analog of the naturally occurring febrifugine, has been shown to prevent fibrosis in various animal models, including those of muscular dystrophies. Here, two optically active enantiomers of deoxyhalofuginone-a halofuginone analogue in which the hydroxy group in position 3 was removed from the piperidinyl entity-were evaluated with respect to their effect on muscle histopathology in mdx mice. Read More

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http://dx.doi.org/10.14670/HH-18-083DOI Listing
January 2019
1 Read

Trehalose in ophthalmology.

Histol Histopathol 2019 Jan 9:18082. Epub 2019 Jan 9.

Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.

Trehalose, a disaccharide of glucose, is a naturally occurring nontoxic and nonreducing bioactive sugar. Trehalose is synthetized by many organisms when cells are exposed to stressful conditions, including dehydration, heat, oxidation, hypoxia or even anoxia. Although trehalose is not synthesized by mammalian cells, it has recently been demonstrated to have a number of important properties that indicate its utility in humans. Read More

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http://dx.doi.org/10.14670/HH-18-082DOI Listing
January 2019
3 Reads

Roles of long-non-coding RNAs in cancer therapy through the PI3K/Akt signalling pathway.

Histol Histopathol 2019 Jan 8:18081. Epub 2019 Jan 8.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Australia.

The vital need for Akt in maintaining basic cellular function has highlighted its importance in carcinogenesis. Unfortunately, Akt inhibitor development outcome has remained poor, as most of them have failed to show significant clinical benefit to cancer patients during the clinical trials. Recently, a new class of non-coding RNAs, known as long non-coding RNAs (lncRNAs), which show high tissue specificity, have demonstrated great influence in cancer progression and/or cancer inhibition. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18081.htm
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http://dx.doi.org/10.14670/HH-18-081DOI Listing
January 2019
3 Reads

A brief review of chordomas: Pathogenesis, prognostic factors and therapeutic targets.

Histol Histopathol 2019 Jan 2:18080. Epub 2019 Jan 2.

Department of Orthopedics, Peking University Third Hospital, Haidian District, Beijing, P.R. China.

Chordomas are rare but locally aggressive cancer, which originate from primitive notochord remnants. Guidelines have recently been proposed to include the option of choosing chordomas in different locations. However, there is still a great challenge in the modern management of chordomas, primarily due to the high recurrence rate and poor prognosis. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18080.htm
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http://dx.doi.org/10.14670/HH-18-080DOI Listing
January 2019
11 Reads

BRAF mutation: Current and future clinical pathological applications in colorectal carcinoma.

Histol Histopathol 2018 Dec 28:18079. Epub 2018 Dec 28.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

The aims are to review the relevance of the BRAF mutations in the clinical settings of colorectal carcinoma. All the literature concerning BRAF mutations and colorectal carcinoma published in PubMed from 2010 to 2018 was reviewed. Multiple variants of BRAF mutations exist in colorectal cancer, the most common type being V600E. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18079.htm
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http://dx.doi.org/10.14670/HH-18-079DOI Listing
December 2018
7 Reads

Morphological rearrangement of the cortical region, in aging ovaries.

Histol Histopathol 2018 Dec 27:18078. Epub 2018 Dec 27.

Departament of Cellular Biology and Physiology. Institute of Biomedical Research, Universidad Nacional Autónoma de México. Mexico City.

The ovary is a structurally dynamic organ that alters with age. Modifications in the paracrine status influence the capacity of aging oocytes to develop normal embryos. Despite the importance of understanding the cellular and molecular mechanism involved in the process of ovarian aging, histological changes remain poorly understood. Read More

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http://dx.doi.org/10.14670/HH-18-078DOI Listing
December 2018

The effect of chronic stress and obesity on sperm quality and testis histology in male rats; a morphometric and immunohistochemical study.

Histol Histopathol 2018 Dec 19:18077. Epub 2018 Dec 19.

Department of Histology and Embryology, Medical School, Sakarya University, Sakarya, Turkey.

Objective: Stress and obesity lead structural and functional abnormalities in many organs. This research investigated the effect of these two risk factors on sperm parameters and histologic structure of testis in rat model.

Materials And Methods: Twenty-four male rats were divided into four groups with six rats in each group as control, stress, obesity, and stress-obesity groups. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18077.htm
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http://dx.doi.org/10.14670/HH-18-077DOI Listing
December 2018
11 Reads

Reduction of PGRN increased fibrosis during skin wound healing in mice.

Histol Histopathol 2018 Dec 18:18076. Epub 2018 Dec 18.

Department of Forensic Medicine, Xuzhou Medical University; Xuzhou, Jiangsu, P.R. China.

Progranulin (PGRN) is a multi-functional growth factor known to be involved in regulating of development, cell cycle progression, cell motility, tumorigenesis and angiogenesis. Research has revealed that PGRN is a crucial mediator of skin wound healing. Nonetheless, the role of PGRN in the fibrosis process of cutaneous wound healing has not been identified. Read More

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http://dx.doi.org/10.14670/HH-18-076DOI Listing
December 2018
1 Read
2.096 Impact Factor

Safety of isotretinoin treatment as measured by liver parameters.

Histol Histopathol 2018 Dec 17:18075. Epub 2018 Dec 17.

Department of Structural and Functional Biology, Biology Institute, University of Campinas, Campinas - SP, Brazil.

Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands it is often prescribed in cases of severe acne treatment. The treatment for the average patient is carried out during two to ten months. This study was designed to investigate liver structure, hepatic enzyme levels and the stress oxidative parameter after isotretinoin treatment during a similar period and using the dosages of 1 mg/kg and another one of 10 mg/kg in young male Wistar rats. Read More

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http://dx.doi.org/10.14670/HH-18-075DOI Listing
December 2018
4 Reads

Histopathology of human small intestinal and colonic ischemia-reperfusion: experiences from human IR-models.

Histol Histopathol 2018 Dec 13:18074. Epub 2018 Dec 13.

NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

Intestinal ischemia-reperfusion (IR) injury is a frequent, but potentially life-threatening condition. Although much has been learned about its pathophysiology from animal IR models, the translation to the human setting is imperative for better understanding of its etiology. This could provide us with new insight into development of early detection and potential new therapeutic strategies. Read More

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http://dx.doi.org/10.14670/HH-18-074DOI Listing
December 2018
1 Read

Parkinson's disease: a short story of 200 years.

Histol Histopathol 2018 Dec 12:18073. Epub 2018 Dec 12.

Clinical and Experimental Neuroscience Group (NiCE-IMIB), Department of Human Anatomy and Psychobiology, Institute for Aging Research, School of Medicine, University of Murcia, Murcia, Spain.

After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Read More

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http://dx.doi.org/10.14670/HH-18-073DOI Listing
December 2018
1 Read

Correlation of securin and Ki67 in invasive breast carcinoma.

Histol Histopathol 2018 Dec 3:18071. Epub 2018 Dec 3.

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Aims: To identify the role of securin (PTTG) as a prognostic marker in invasive breast carcinoma and its possible relation to ki67 and to evaluate the use of ImmunoRatio® as a tool for calculating ki67 and securin labelling indices.

Methods: Securin and ki67 immunohistochemical staining were performed on tissue microarray sections representative of 118 patients diagnosed with invasive breast carcinoma from 2005 to 2011. Assessment of immunohistochemical staining was carried out using both visual counting and ImmunoRatio®. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18071.htm
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http://dx.doi.org/10.14670/HH-18-071DOI Listing
December 2018
3 Reads
2.096 Impact Factor

The distribution and time-dependent expression of HIPK2 during the repair of contused skeletal muscle in mice.

Histol Histopathol 2018 Dec 5:18072. Epub 2018 Dec 5.

Department of Forensic Pathology, China Medical University School of Forensic Medicine, Liaoning Province, PR China.

HIPK2 is an evolutionarily conserved serine/threonine kinase and is considered a co-regulator of an increasing number of transcription factors modulating a variety of cellular processes, including inflammation, proliferation and fibrosis. Skeletal muscle injuries repair is an overlapping event between inflammation and tissue repair. There are no reports about HIPK2 expression in skeletal muscles after trauma. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18072.htm
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http://dx.doi.org/10.14670/HH-18-072DOI Listing
December 2018
2 Reads

Cytokeratin expression profiles of canine epithelial tissues.

Histol Histopathol 2018 Nov 30:18070. Epub 2018 Nov 30.

Institute of Pathology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Cytokeratins (CKs) are intermediate filaments of epithelial cells. In humans, different types of epithelia as well as their neoplasms show distinct CK expression profiles. The aim of this study was to establish a panel of CKs for the identification of specialized canine epithelia that can be integrated in a routine diagnostic setting. Read More

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http://dx.doi.org/10.14670/HH-18-070DOI Listing
November 2018
1 Read

Immunohisto(cyto)chemistry: an old time classic tool driving modern oncological therapies.

Histol Histopathol 2018 Nov 27:18069. Epub 2018 Nov 27.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

In the era of precision medicine immunohistochemistry (IHC) and immunocytochemistry (ICC) share some of the highlights in personalized treatment. Survival data obtained from clinical trials shape the cut-offs and IHC scoring that serve as recommendations for patient selection both for targeted and conventional therapies. Assessment of Estrogen and Progesterone Receptors along with HER2 status has been among the first approved immunostaining assays revolutionizing breast cancer treatment. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18069.htm
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http://dx.doi.org/10.14670/HH-18-069DOI Listing
November 2018
9 Reads

STIM promotes the epithelial-mesenchymal transition of podocytes through regulation of FcγRII activity in diabetic nephropathy.

Histol Histopathol 2018 Nov 26:18068. Epub 2018 Nov 26.

Department of Nephrology, Zhejiang Provincial People's Hospital, Zhejiang, P.R. China.

Background: Diabetic nephropathy (DN) is a serious complication in diabetic patients and has been considered as the main cause of end-stage renal disease. However, there are no studies on the role of stromal interaction molecule (STIM) and its two subtypes, STIM1 and STIM2, in the epithelial-to-mesenchymal transition (EMT) of podocytes induced by diabetic kidney disease (DKD). The present study suggests for the first time that STIM inhibition decreases DKD-induced EMT. Read More

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http://www.hh.um.es/Abstracts/Vol_/_/__18068.htm
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http://dx.doi.org/10.14670/HH-18-068DOI Listing
November 2018
9 Reads

Next-generation sequencing-based characterization of the invasion by anatomical contiguity in a primary osseous diffuse large B-cell lymphoma. Correlation between the genetic profile of the malignancy and the clinical outcome of the patient.

Histol Histopathol 2018 Nov 23:18067. Epub 2018 Nov 23.

Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Primary bone lymphoma is now a well-described entity in the World Health Organization (WHO) Classification of Tumors of Soft Tissue and Bone as a malignancy of the lymphoid tissue, with at least one mass within bone, without involvement of supraregional lymph nodes or other extranodal sites. In the current paper, we describe the complete characterization of the mutational landscape of a diffuse large B cell non-Hodgkin's lymphoma (DLBLCL) of the tibial plateau. Currently, there is very little data about the genetic landscape of primary osseous lymphomas and about the genetic background of this type of malignancy, resistant to chemotherapy and invading the surrounding tissues. Read More

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http://dx.doi.org/10.14670/HH-18-067DOI Listing
November 2018
2 Reads

Epstein - Barr virus association with plasma cell neoplasms.

Histol Histopathol 2018 Nov 19:18066. Epub 2018 Nov 19.

Department of Pathology and Laboratory Medicine, University of California Irvine (UCI), Irvine, CA, USA.

Aims: Epstein-Barr virus (EBV) expression has been reported in several hematopoietic and non-hematopoietic disorders but its expression in plasma cell neoplasms has been largely limited to immunodeficiency-related cases such as in the setting of post-organ transplantation or human immunodeficiency virus (HIV) infection. The aim of this study is to evaluate the association of EBV with plasma cell neoplasms, mainly in immunocompetent patients.

Methods And Results: We retrospectively studied 147 cases of patients with different plasma cell neoplasms (109 plasma cell myelomas, 22 plasmacytomas, and 16 monoclonal gammopathy cases). Read More

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http://dx.doi.org/10.14670/HH-18-066DOI Listing
November 2018
13 Reads

Melatonin promotes self-renewal and nestin expression in neural stem cells from the retina.

Histol Histopathol 2018 Nov 16:18065. Epub 2018 Nov 16.

College of Basic Medicine, Jining Medical University, Jining, Shandong Province, R.P. China.

Although melatonin has been shown to exhibit a wide variety of biological functions, its effects on promoting self-renewal in retinal stem cells remain unknown. We found that melatonin can significantly increase proliferation and enhance expression of a stem cell marker, nestin, in retinal neural stem cells (NSCs) via melatonin receptor 1 (MT1). The ERK pathway inhibitor SCH772984 and TGF-β pathway inhibitor SB431542 were used to study the melatonin-mediated molecular mechanisms of cell proliferation in NSCs. Read More

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http://dx.doi.org/10.14670/HH-18-065DOI Listing
November 2018
14 Reads

Solitary fibrous tumor: an evolving and unifying entity with unsettled issues.

Histol Histopathol 2018 Nov 15:18064. Epub 2018 Nov 15.

Departments of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Solitary fibrous tumor (SFT) is a distinct fibroblastic neoplasm of intermediate biological potential, prototypically presenting as a pleura-associated tumor characterized by patternless proliferation of generally banal oval to spindle cells with hemangiopericytoma-like staghorn vessels in fibrocollagenous stroma. Over the past decades, the clinicopathological spectrum of SFT has been ever-expanding with the incorporation of cases exhibiting myxoid, giant cell-containing, and fat-forming histology, as well as those from extrathoracic sites, including the meninx. Atypical, frankly malignant and even dedifferentiated variants have also been recognized in a subset of SFTs. Read More

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http://dx.doi.org/10.14670/HH-18-064DOI Listing
November 2018
10 Reads

Assessment of morphological changes and steroid receptors in the uteri of postmenopausal women.

Histol Histopathol 2018 Nov 14:18063. Epub 2018 Nov 14.

Department of Histology and Developmental Biology, Pomeranian Medical University, Szczecin, Poland.

Introduction: The morphology of the endometrium constantly changes in the reproductive period, depending on the levels of ovarian steroid hormones, and undergoes atrophic changes during menopause as a result of their insufficiency. The purpose of this study was to analyze morphological and morphometric changes in the mucous and muscle layers of the uterine wall in postmenopausal women, and to assess localization and number of cells showing the expression of steroid hormone receptors, namely estrogen receptor α (ER-α), progesterone receptor (PR), and androgen receptor (AR) in glandular epithelial cells and smooth muscle cells in particular groups of women.

Material And Methods: The study material consisted of uterine specimens sectioned across the full thickness of the uterine wall, and embedded in 164 paraffin blocks. Read More

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http://dx.doi.org/10.14670/HH-18-063DOI Listing
November 2018
7 Reads

Wnt signaling in physiological and pathological bone formation.

Histol Histopathol 2018 Nov 13:18062. Epub 2018 Nov 13.

School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Wnt signaling, canonical or non-canonical, plays conserved roles in numerous physiological and pathological processes. However, it is well beyond the scope of this review to cover all functional aspects of Wnt signaling in different contexts at reasonable depth; therefore this review intends to cover only the roles of Wnt signaling in bone biology; more specifically, we intend to first update the roles of Wnt signaling in physiological bone process, including in osteogenesis and chondrogenesis, since recent years have witnessed tremendous progressions in this area, and then we seek to extend our understanding to the pathological bone process, especially to the heterotopic ossification (HO), even though the understanding of Wnt signaling in HO has been limited. We then further clarify the potential crosstalking between Wnt and other conserved signaling pathways, including FGF, GPCR and Hif1α pathways. Read More

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https://www.ahajournals.org/doi/abs/10.1161/circresaha.110.2
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http://www.hh.um.es/Abstracts/Vol_/_/__18062.htm
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http://dx.doi.org/10.14670/HH-18-062DOI Listing
November 2018
9 Reads

Infiltrated M2 tumour-associated macrophages in the stroma promote metastasis and poor survival in oesophageal squamous cell carcinoma.

Histol Histopathol 2018 Nov 12:18061. Epub 2018 Nov 12.

Tumor Hospital Affiliated to Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, P.R. China.

Although M2 tumour-associated macrophages (M2 TAMs) have been shown to be associated with the progression and metastasis of breast cancer, their role in oesophageal squamous cell carcinoma (ESCC) remains less well understood. Therefore, to understand the clinicopathological significance of infiltrated M2 TAMs in ESCC, statistical analysis was performed after immunohistochemical evaluation of CD163 expression, a well-accepted surface marker of M2 TAMs in ESCC. To gain insight into the effect of M2 TAMs, ESCC cell lines Eca109 and KYSE150 cells were co-cultured with M2 TAMs artificially induced from THP-1 cells. Read More

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http://dx.doi.org/10.14670/HH-18-061DOI Listing
November 2018
2 Reads
2.100 Impact Factor

Evaluation of retinal injury in a rat model of transient ischemic stroke.

Histol Histopathol 2018 Nov 9:18060. Epub 2018 Nov 9.

Department of Respiratory Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, China.

Stroke-associated ocular disorders are vision-threatening. This study was designed to evaluate in vivo retinal injury induced by transient global cerebral ischemia/reperfusion (I/R). A stroke-induced retinal injury model in Wistar rats was established by electrocoagulation of bilateral vertebral arteries, combined with transient ligation of the bilateral common carotid arteries. Read More

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http://dx.doi.org/10.14670/HH-18-060DOI Listing
November 2018
7 Reads

A plant proteinase inhibitor from enterolobium contortisiliquum attenuates airway hyperresponsiveness, inflammation and remodeling in a mouse model of asthma.

Histol Histopathol 2018 Nov 8:18059. Epub 2018 Nov 8.

Faculdade de Medicina FMUSP, Universidade de São Paulo, Department of Clinical Medicine, São Paulo, Brazil.

Introduction: Proteinase inhibitors have been associated with anti-inflammatory and antioxidant activities and may represent a potential therapeutic treatment for asthma.

Purpose: The aim of the present study was to evaluate the effects of Enterolobium contortisiliquum trypsin inhibitor (EcTI) on pulmonary mechanical function, eosinophilic recruitment, inflammatory cytokines, remodeling and oxidative stress in an experimental model of chronic allergic pulmonary inflammation.

Methods: BALB/c mice were divided into 4 groups: C (saline i. Read More

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http://dx.doi.org/10.14670/HH-18-059DOI Listing
November 2018
23 Reads

Impaired spermatogenesis, tubular wall disruption, altered blood-testis barrier composition and intratubular lymphocytes in an infertile Beagle dog - a putative case of autoimmune orchitis.

Histol Histopathol 2018 Nov 7:18058. Epub 2018 Nov 7.

Institute for Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany.

Impairment of blood-testis barrier integrity can be observed during inflammation, infection, trauma and experimental autoimmune orchitis, which is inducible in rodents. In the present study, an initially fertile two-year-old Beagle dog was presented with a decline in total sperm number resulting in azoospermia within five months, verified by twice-monthly semen analyses. The dog was clinically healthy with bilateral small testes and showed normal thyroid function. Read More

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http://dx.doi.org/10.14670/HH-18-058DOI Listing
November 2018
8 Reads

Umbilical cord-derived mesenchymal stromal/stem cells enhance recovery of surgically induced skeletal muscle ischemia in a rat model.

Histol Histopathol 2018 Nov 6:18057. Epub 2018 Nov 6.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, Moscow, Russian Federation.

This study delves into possible mechanisms underlying the stimulating influence of UC-MSCs transplantation on functional and structural recovery of ischemic skeletal muscles. Limb ischemia was created in Sprague-Dawley rats by excision of femoral and popliteal arteries. Allogeneic rat PKH26-labeled UC-MSCs were administered by direct intramuscular injection. Read More

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http://dx.doi.org/10.14670/HH-18-057DOI Listing
November 2018
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4-(3,4-dihydroxybenzoyloxymethyl)phenyl-O-β-D-glucopyranoside effect in liver regeneration.

Histol Histopathol 2018 Nov 5:18056. Epub 2018 Nov 5.

Department of Histology and Embryology, Faculty of Medicine, Near East University, Nicosia, Cyprus.

Following an injury or resection, the mammalian liver has the capacity to regain its former volume and functioning by restoring itself. Studies have demonstrated that antioxidants play a role in hepatic regeneration. This study investigated the effect of 4-(3,4-dihydroxybenzoyloxymethyl) phenyl-O-β-D-glucopyranoside (PG) obtained from Origanum micranthum on liver regeneration. Read More

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http://dx.doi.org/10.14670/HH-18-056DOI Listing
November 2018
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Abundant proliferating cells within early chicken taste buds indicate a potentially "built-in" progenitor system for taste bud growth during maturation in hatchlings.

Histol Histopathol 2018 Oct 31:18055. Epub 2018 Oct 31.

Regenerative Bioscience Center, Department of Animal and Dairy Science, College of Agricultural and Environmental Sciences, University of Georgia, Athens, GA, USA.

Like other epithelial cells, taste bud cells have a short life span and undergo continuous turnover. An active stem or progenitor cell niche is essential for taste bud formation and maintenance. Early taste bud cells have a life span of ~4 days on average in chicken hatchlings when taste buds grow rapidly and undergo maturation. Read More

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http://dx.doi.org/10.14670/HH-18-055DOI Listing
October 2018
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The expression of death receptor systems TRAIL-R1/-R2/-R4, CD95 and TNF-R1 and their cognate ligands in pancreatic ductal adenocarcinoma.

Histol Histopathol 2018 Oct 24:18054. Epub 2018 Oct 24.

Institute for Experimental Cancer Research, Christian-Albrechts-University, Kiel, Germany.

The expression of five members of the TNF receptor superfamily and two of their ligands in human pancreatic ductal adenocarcinoma were investigated in parallel by immunohistochemistry. 41 patients with histologically confirmed ductal carcinoma of the pancreas were enrolled in this study in order (i) to compare the individual TNFR-SF expression and their ligands in PDAC-cells and (ii) to investigate their correlation with survival data. All patients had undergone pancreaticoduodenectomy and were staged as pT3N1M0. Read More

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http://dx.doi.org/10.14670/HH-18-054DOI Listing
October 2018

Beyond p16 immunostaining: an overview of biomarkers in anal squamous intraepithelial lesions.

Histol Histopathol 2018 Oct 19:18053. Epub 2018 Oct 19.

Faculty of Medicine of the University of Porto, Porto, Portugal.

Histological grading of squamous intraepithelial lesions or intraepithelial neoplasia is fundamental for clinical management and for assessment of the risk of progression. Biomarkers are important for assisting correct grading of these lesions, reducing inter and intraobserver variability and most promising, for prognosis. Although p16 is the most studied biomarker in this setting, there are several other biomarkers that have been studied, reflecting also the need to find a better single or association option that can be more suitable, especially for classification purposes. Read More

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http://dx.doi.org/10.14670/HH-18-053DOI Listing
October 2018
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2.100 Impact Factor

Protective effect of alpha-mangostin on thioacetamide-induced liver fibrosis in rats as revealed by morpho-functional analysis.

Histol Histopathol 2018 Oct 11:18052. Epub 2018 Oct 11.

Department of Anatomy, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

Liver fibrosis is an excessive accumulation of scar tissue resulting from inflammation and cell death. Thioacetamide (TAA) is a well-known hepatotoxin that induces liver fibrosis. A marker of injured hepatocytes is transforming growth factor-beta 1 (TGF-β1), while alpha-smooth muscle actin (α-SMA) and tissue inhibitor of metalloproteinase 1 (TIMP-1) are markers of activated hepatic stellate cells. Read More

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http://dx.doi.org/10.14670/HH-18-052DOI Listing
October 2018
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Membrane trafficking and exocytosis are upregulated in port wine stain blood vessels.

Histol Histopathol 2018 Oct 10:18051. Epub 2018 Oct 10.

Department of Surgery, Beckman Laser Institute and Medical Clinic, University of California, Irvine, California, USA.

Introduction: Port wine stain (PWS) is characterized as a progressive dilatation of immature venule-like vasculatures which result from differentiation-impaired endothelial cells. In this study, we aimed to identify the major biological pathways accounting for the pathogenesis of PWS.

Methods: Sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) was used to identify differentially expressed proteins in PWS lesions, followed by confirmative studies with immunohistochemistry, immunoblot and transmission electron microscopy (TEM). Read More

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October 2018
12 Reads
2.100 Impact Factor

APOBEC3B protein expression and mRNA analyses in patients with high-grade serous ovarian carcinoma.

Histol Histopathol 2018 Oct 5:18050. Epub 2018 Oct 5.

Tumor Bank Ovarian Cancer Network (TOC), Berlin, Germany.

APOBEC3 enzymes are part of the innate immune system and they are important in retroviral defense. The number of mutations in ovarian cancer increases with rising levels of APOBEC3B mRNA. We could confirm that APOBEC3B mRNA is upregulated in ovarian cancer cell lines and in ovarian cancer tissue. Read More

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October 2018
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The effect of 2.45 GHz non-ionizing radiation on the structure and ultrastructure of the testis in juvenile rats.

Histol Histopathol 2018 Sep 27:18049. Epub 2018 Sep 27.

Department of Anatomy, Histology and Physiology, Institute of Histology and Embryology, University of Veterinary Medicine and Pharmacy in Košice, Slovakia.

Background: Nowadays, mobile devices that emit non-ionizing electromagnetic radiation (EMR) are predominantly used by juveniles and pubescents. The aim of the present study was to evaluate the effect of whole body pulsed EMR on the juvenile Wistar albino rat testis at a frequency of 2.45 GHz and mean power density of 2. Read More

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http://dx.doi.org/10.14670/HH-18-049DOI Listing
September 2018
5 Reads

Anti-apoptotic effects and mechanisms of salvianolic acid A on cardiomyocytes in ischemia-reperfusion injury.

Histol Histopathol 2018 Sep 26:18048. Epub 2018 Sep 26.

Institute of Cardiovascular Disease Research, Xuzhou Medical University, Jiangsu Province, P.R. China.

Prompt myocardial reperfusion during acute myocardial infarction by fibrinolytic therapy, percutaneous coronary intervention, or coronary artery bypass grafting limits the affected area and improves prognosis. However, reperfusion itself can cause cardiomyocyte damage and decrease treatment efficacy. No treatments that effectively prevent myocardial ischemia/reperfusion (I/R) injury are currently available, and are therefore the focus of ongoing research. Read More

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http://dx.doi.org/10.14670/HH-18-048DOI Listing
September 2018
12 Reads

Influence of examiners experience on the reproducibility of different gold standard techniques and histological criteria for validation of the diagnosis of occlusal caries lesions.

Histol Histopathol 2018 Sep 25:18047. Epub 2018 Sep 25.

Department of Surgery and Orthopedics, School of Dentistry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

The aims of this study were to evaluate the influence (1) of the examiner experience and (2) three histological classification criteria on the reproducibility of two gold standard techniques (non-dye or dye) for validation of the diagnosis of occlusal caries. This study comprised a sample of 210 digital images of 105 permanent teeth (105 rhodamine B dyed and 105 dye-free hemisections) and six examiners. Images were evaluated on a laptop computer and categorised according to three different histological classification criteria (proposed by Ekstrand, Lussi or Downer) and repeated in order to allow reproducibility calculation. Read More

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http://dx.doi.org/10.14670/HH-18-047DOI Listing
September 2018
1 Read

Clinical significance and EZH2, ERG and SPINK1 protein expression in pure and mixed ductal adenocarcinoma of the prostate.

Histol Histopathol 2018 Sep 24:18046. Epub 2018 Sep 24.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Although ERG and SPINK1 molecular alterations have been studied in acinar and ductal adenocarcinoma of the prostate, EZH2 expression has not been previously evaluated in ductal adenocarcinoma.

Methods: We collected cases of pure and mixed ductal adenocarcinoma of the prostate and evaluated clinical significance and EZH2, ERG, and SPINK1 protein expression.

Results: We investigated 61 ductal adenocarcinomas, 22 pure and 39 mixed ductal/acinar. Read More

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http://dx.doi.org/10.14670/HH-18-046DOI Listing
September 2018
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Clinicopathological features and lymph node metastatic patterns of gastric mixed adenoneuroendocrine carcinoma.

Histol Histopathol 2018 Sep 21:18045. Epub 2018 Sep 21.

Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Aims: Mixed adenoneuroendocrine carcinoma (MANEC), also known as high- grade mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) in the World Health Organization (WHO) classification of tumors of the endocrine organs (2017), is a rare gastric malignancy. Here, we present 10 cases of gastric MANEC and analyse their clinicopathological features and lymph node metastatic patterns.

Methods And Results: Six patients were male, and four were female. Read More

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http://dx.doi.org/10.14670/HH-18-045DOI Listing
September 2018
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Multichromatic TTF staining characterizes cartilage matrix in osteoarthritis and bone development.

Histol Histopathol 2018 Sep 20:18044. Epub 2018 Sep 20.

Department of Orthopaedics and Traumatology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Various histological staining methods have been explored to detect the joint lesions in osteoarthritis (OA), but these histological stains cannot comprehensively present the comparatively complex structures of articular cartilage in knee OA. In addition, no integrated histological staining method can be used to evaluate efficiently both the subzone region and matrix composition in cartilage containing tissues. Therefore, in this study, a novel multichromatic staining method termed TTF staining, using Toluidine Blue (T), Tartrazine (T) and Fast Green (F) sequential combined staining for histological analysis, has been exploited to characterize the changes of matrix components and contents in cartilage during OA and in the bone development. Read More

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http://dx.doi.org/10.14670/HH-18-044DOI Listing
September 2018

LncRNA HOTTIP mediated DKK1 downregulation confers metastasis and invasion in colorectal cancer cells.

Histol Histopathol 2018 Sep 19:18043. Epub 2018 Sep 19.

Department of General Surgery, Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Jiangsu, China.

Recent studies highlight long non-coding RNAs (lncRNAs) as key regulators of cancer biology that contribute to carcinogenesis. The lncRNA HOXA transcript at the distal tip (HOTTIP) is involved in the development of several cancers. Previous studies demonstrated that HOTTIP could promote colorectal cancer (CRC) cell proliferation via silencing of p21 expression. Read More

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http://dx.doi.org/10.14670/HH-18-043DOI Listing
September 2018
3 Reads