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    Efficacy and safety of calcineurin inhibitor treatment for IgA nephropathy: a meta-analysis.
    BMC Nephrol 2017 Feb 13;18(1):61. Epub 2017 Feb 13.
    Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, 28 Fuxing Road, Beijing, 100853, People's Republic of China.
    Background: IgA nephropathy is the most common progressive glomerular disease to end stage renal failure worldwide. Calcineurin inhibitors (CNIs) is a selective immunosuppressant widely used in organ transplantation. The efficacy and safety of calcineurin inhibitors for the treatment of IgA nephropathy remain uncertain. Read More

    C-Peptide, Baseline and Postprandial Insulin Resistance after a Carbohydrate-Rich Test Meal - Evidence for an Increased Insulin Clearance in PCOS Patients?
    Geburtshilfe Frauenheilkd 2017 Jan;77(1):59-65
    Frauenklinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany.
    Introduction Known characteristics of patients with PCOS include infertility, menstrual disorders, hirsutism and also often insulin resistance. These symptoms increase with increasing body weight. In the LIPCOS study (Lifestyle Intervention for Patients with Polycystic Ovary Syndrome [PCOS]) long-term changes of the PCOS in dependence on pregnancy and parenthood were systematically assessed. Read More

    Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma.
    Tohoku J Exp Med 2017 ;241(2):125-129
    Department of Endocrinology and Diabetes, Japan Community Health care Organization Chukyo Hospital.
    Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7. Read More

    High serum progesterone associated with infertility in a woman with nonclassic congenital adrenal hyperplasia.
    J Obstet Gynaecol Res 2017 Feb 11. Epub 2017 Feb 11.
    Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Nonclassic congenital adrenal hyperplasia (NCAH) is an autosomal-recessive disorder caused by 21-hydroxylase deficiency and manifests as hirsutism and oligomenorrhea due to excess adrenal androgen and progesterone. We report a case of a woman with NCAH who showed continuous high serum progesterone levels in the follicular phase associated with impaired folliculogenesis. NCAH was diagnosed based on high 17-hydroxyprogesterone levels after rapid adrenocorticotropic hormone loading, and three heterozygous missense mutations in CYP21A2, encoding 21-hydroxylase, were identified. Read More

    Appearance of a thymic mass after treatment of Cushing's syndrome.
    Asian Cardiovasc Thorac Ann 2017 Feb 19;25(2):150-153. Epub 2016 Dec 19.
    1 Internal Medicine Unit, University Hospital of Sassari, Sassari, Italy.
    A 23-year-old woman was referred to our center with hirsutism, acne, weight gain, weakness, and irregular menses. Laboratory tests revealed increased levels of cortisol and sex hormones, and reduced adrenocorticotropic hormone levels. The patient underwent a right adrenalectomy. Read More

    Is acne a sign of androgen excess disorder or not?
    Eur J Obstet Gynecol Reprod Biol 2017 Jan 23;211:21-25. Epub 2017 Jan 23.
    Department of Endocrinology, Erciyes University Medical School, Kayseri, Turkey.
    Objective: Acne is not solely a cosmetic problem. The clinical importance of acne in the estimation of androgen excess disorders is controversial. Recently, the Amsterdam ESHRE/ASRM-sponsored third PCOS Consensus Workshop Group suggested that acne is not commonly associated with hyperandrogenemia and therefore should not be regarded as evidence of hyperandrogenemia. Read More

    Standardised versus individualised multiherb Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: a randomised feasibility and pilot study in the UK.
    BMJ Open 2017 Feb 3;7(2):e011709. Epub 2017 Feb 3.
    University of Southampton Primary Care and Population Sciences Aldermoor Health Centre Aldermoor Close, Southampton, UK.
    Objectives: To explore feasibility of a randomised study using standardised or individualised multiherb Chinese herbal medicine (CHM) for oligomenorrhoea and amenorrhoea in women with polycystic ovary syndrome (PCOS), to pilot study methods and to obtain clinical data to support sample size calculations.

    Design: Prospective, pragmatic, randomised feasibility and pilot study with participant and practitioner blinding.

    Setting: 2 private herbal practices in the UK. Read More

    Ovarian steroid cell tumor, not otherwise specified: A case report and literature review.
    Mol Clin Oncol 2016 Dec 1;5(6):839-841. Epub 2016 Nov 1.
    Department of Obstetrics and Gynecology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China.
    Steroid cell tumors (SCT), not otherwise specified (NOS) are particularly rare ovarian sex cord-stromal tumors, which comprise <0.1% of all ovarian tumors. These tumors are uncommon in patients' prior to puberty without any typical syndromes involving hirsutism, virilization and hypertension. Read More

    Racial and Ethnic Differences in the Polycystic Ovary Syndrome (PCOS) Metabolic Phenotype.
    Am J Obstet Gynecol 2017 Jan 16. Epub 2017 Jan 16.
    Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Aurora, CO.
    Background: Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome amongst women with polycystic ovarian syndrome is important for prevention strategies. Read More

    Novel findings of left ventricular non-compaction cardiomyopathy, microform cleft lip and poor vision in patient with SMC1A-associated Cornelia de Lange syndrome.
    Am J Med Genet A 2017 Feb 7;173(2):414-420. Epub 2016 Nov 7.
    Division of Cardiology, Seattle Children's Hospital, Seattle, Washington.
    Relatively few patients with Cornelia de Lange syndrome (CdLS) due to SMC1A mutation have been reported, limiting understanding of the full extent of the phenotype. Compared to children with classic NIPBL-associated CdLS, patients with SMC1A-associated CdLS have a milder physical phenotype with prominent intellectual disability, high rate of cleft palate and absence of limb reductions. We present a patient with SMC1A-associated CdLS who had typical features including developmental delay, seizure disorder, feeding difficulties, hirsutism, and cleft palate. Read More

    Hyperandrogenism in a postmenopausal woman: a rare case of ectopic adrenal cortical gland.
    Gynecol Endocrinol 2017 Jan 19:1-3. Epub 2017 Jan 19.
    a Department of Medical and Surgical Sciences and Translational Medicine and.
    Most frequent causes of androgenic manifestation are Cushing's syndrome, PCO, benign and malignant androgen-secreting non adrenal tumors and iatrogenic hirsutism. Hyperplasia or neoplasms of ectopic adrenocortical gland are rare. We report a case of a 63-year old female with hirsutism and alopecia. Read More

    Quantifying cutaneous adverse effects of systemic glucocorticoids in patients with rheumatoid arthritis: a cross-sectional cohort study.
    Clin Exp Rheumatol 2017 Jan 15. Epub 2017 Jan 15.
    Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany.
    Objectives: EULAR guidelines state that adverse effects (AEs) of glucocorticoid (GC) therapy should be considered and discussed with the patient before treatment is initiated. However, reliable quantitative data, especially on cutaneous AEs of low-to-medium dose GCs are lacking. We performed a study assessing the occurrence of cutaneous AEs of GCs and its association with current and cumulative GC doses in patients with rheumatoid arthritis (RA). Read More

    Diagnostic and management challenges from childhood, puberty through to transition in severe insulin resistance due to insulin receptor mutations.
    Pediatr Diabetes 2017 Jan 17. Epub 2017 Jan 17.
    Department of Paediatric Endocrinology and Diabetes, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
    Two Caucasian girls, both of normal weight and body mass indices, were diagnosed with type A insulin resistance (IR) in childhood. Case 1 presented with premature adrenarche aged 7 years, then by age 12 years had hirsutism, acne, acanthosis nigricans, and asymptomatic diabetes. Subsequent investigation revealed raised adiponectin (15. Read More

    Metformin vs myoinositol: which is better in obese polycystic ovary syndrome patients? A randomized controlled crossover study.
    Clin Endocrinol (Oxf) 2017 Jan 16. Epub 2017 Jan 16.
    Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, Roma, Italy.
    Context: Due to the central role of metabolic abnormalities in the pathophysiology of polycystic ovary syndrome (PCOS), insulin sensitizing agents have been proposed as a feasible treatment option.

    Objective: To investigate which is the more effective between metformin and myoinositol (MYO) on hormonal, clinical and metabolic parameters in obese patients with PCOS.

    Study Design: Crossover randomized controlled study. Read More

    Prevalence of hormonal and endocrine dysfunction in patients with lichen planopilaris (LPP): A retrospective data analysis of 168 patients.
    J Am Acad Dermatol 2017 Feb;76(2):314-320
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:
    Background: Studies on the pathophysiology and comorbidities associated with lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are limited.

    Objective: The purpose of this study was to determine the prevalence of androgen excess in the postmenopausal LPP population, in relation to demographics and comorbidities.

    Methods: A retrospective data analysis of 413 patients with LPP, FFA, and LPP/FFA seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2005 and 2015 was conducted. Read More

    A Comparison of Sexual Function in Women with Polycystic Ovary Syndrome (PCOS) Whose Mothers Had PCOS During Their Pregnancy Period with Those Without PCOS.
    Arch Sex Behav 2017 Jan 9. Epub 2017 Jan 9.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women during reproductive ages. Clinical symptoms associated with PCOS, such as hirsutism, acne, alopecia, obesity, and infertility, may lead to emotional morbidity and then impaired sexual function in those affected. During intrauterine development, the fetus may program the development of diseases during adulthood. Read More

    Adult Acne: Prevalence and Portrayal in Primary Healthcare Patients, in the Greater Porto Area, Portugal.
    Acta Med Port 2016 Sep 30;29(9):507-513. Epub 2016 Sep 30.
    Centro de Investigação Interdisciplinar em Saúde. Universidade Católica do Porto. Porto. Portugal.
    Introduction: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. Read More

    Women With Polycystic Ovary Syndrome Have Comparable Hip Bone Geometry to Age-Matched Control Women.
    J Clin Densitom 2016 Dec 26. Epub 2016 Dec 26.
    College of Kinesiology, Physical Activity Complex, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK S7N 5B2, Canada. Electronic address:
    Polycystic ovary syndrome (PCOS) is an endocrine disorder affecting women of reproductive age manifesting with polycystic ovaries, menstrual irregularities, hyperandrogenism, hirsutism, and insulin resistance. The oligomenorrhea and amenorrhea characteristic to PCOS are associated with low bone mineral density (BMD); conversely, the hyperandrogenism and hyperinsulinemia may elicit a protective effect on BMD. As bone geometric properties provide additional information about bone strength, the objective of this study was to compare measures of hip geometry in women with PCOS to a healthy female population. Read More

    The frequency of polycystic ovary syndrome in young reproductive females in Qatar.
    Int J Womens Health 2017 16;9:1-10. Epub 2016 Dec 16.
    Biomedical Sciences Department, College of Health Sciences, Qatar University, Doha, Qatar; Physiology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.
    This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, and anthropometric measurements. The diagnostic criteria of the US National Institutes of Health criteria were used. Menstrual irregularities (MI) were identified, and clinical hyperandrogenism was evaluated by self-assessment of hirsutism using modified Ferriman-Gallwey score. Read More

    Overweight and obese but not normal weight women with PCOS are at increased risk of Type 2 diabetes mellitus-a prospective, population-based cohort study.
    Hum Reprod 2017 Feb 28;32(2):423-431. Epub 2016 Dec 28.
    Department of Obstetrics and Gynaecology, Oulu University Hospital, University of Oulu, Medical Research Center Oulu and PEDEGO Research Unit, FI-90029, OYS, Oulu, Finland
    Study Question: What are the respective roles of polycystic ovary syndrome (PCOS), long-term weight gain and obesity for the development of prediabetes or Type 2 diabetes mellitus (T2DM) by age 46 years?

    Summary Answer: The risk of T2DM in women with PCOS is mainly due to overweight and obesity, although these two factors have a synergistic effect on the development of T2DM.

    What Is Known Already: PCOS is associated with an increased risk of prediabetes and T2DM. However, the respective roles of PCOS per se and BMI for the development of T2DM have remained unclear. Read More

    Cardiovascular system diseases in patients with polycystic ovary syndrome - the role of inflammation process in this pathology and possibility of early diagnosis and prevention.
    Ann Agric Environ Med 2016 12;23(4):537-541
    Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University, Szczecin, Poland.
    Polycystic ovary syndrome is a disorder which affects 5-10% of women in reproductive age. PCOS is a cause of hyperandrogenism, menstrual disorders and infertility. The most common clinical symptoms are hirsutism, acne and obesity. Read More

    Calcineurin inhibitors versus cyclophosphamide for idiopathic membranous nephropathy: A systematic review and meta-analysis of 21 clinical trials.
    Autoimmun Rev 2017 Feb 15;16(2):136-145. Epub 2016 Dec 15.
    Public health department, AixMarseille university, Marseille, France.
    Objective: To compare the efficacy and safety of calcineurin inhibitors (CNIs) with cyclophosphamide (CTX) in the treatment of idiopathic membranous nephropathy (IMN).

    Methods: A literature search was carried out using PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and three Chinese databases (WanFang Data, Chongqing VIP and China National Knowledge Infrastructure) from inception through June 2016. Randomized controlled trials (RCTs) comparing the efficacy and safety of CNIs with CTX in IMN patients were included. Read More

    Cushing's disease: a multidisciplinary overview of the clinical features, diagnosis, and treatment.
    J Med Life 2016 Jan-Mar;9(1):12-18
    "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; C.I. Parhon National Institute of Endocrinology, Bucharest, Romania.
    Cushing's disease is considered a rare condition characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that ultimately causes endogenous hypercortisolism by stimulating the adrenal glands. The clinical signs suggesting Cushing's disease, such as obesity, moon face, hirsutism, and facial plethora are already present on presentation. Endogenous hypercortisolism is associated with an increased risk of cardiovascular and metabolic manifestations, as well as respiratory disorders, psychiatric complications, osteoporosis and infections, leading to high rates of morbidity and mortality. Read More

    Bariatric Surgery, Polycystic Ovary Syndrome, and Infertility.
    J Obes 2016 14;2016:1871594. Epub 2016 Nov 14.
    University Hospital Lewisham, Lewisham and Greenwich NHS Trust, London, UK.
    Background. Polycystic ovary syndrome (PCOS) is the commonest cause of female infertility. Visceral obesity and insulin resistance are key pathophysiological mechanisms behind PCOS. Read More

    Skin manifestations of Cushing's syndrome.
    Rev Endocr Metab Disord 2016 Sep;17(3):283-286
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room East 1330, CRC, 10 Center Dr. MSC1862, Bethesda, MD, 20892-1862, USA.
    Among the most common diagnostic manifestations of Cushing's syndrome (CS) are those involving the skin; they include violaceous striae, facial acne, hirsutism, acanthosis nigricans (AN), fungal infections, hyperpigmentation (Hp) and easy bruisability. Fortunately, most resolve within a year or two after cure of CS, although light-colored striae can persist for years depending on the age of the patients. AN, Hp, and bruisability usually resolve within months after cure in almost all ages. Read More

    Endocrinology Update: Hirsutism.
    FP Essent 2016 Dec;451:17-24
    University of Michigan Medical School Ypsilanti Health Center, 200 Arnet Suite 200, Ypsilanti, MI 48198.
    Hirsutism is defined as excessive terminal hair growth, such as coarse sexual or secondary hair, that typically appears in a male growth pattern in androgen-dependent areas of the female body. It can occur in men and women. Common etiologies include polycystic ovary syndrome, idiopathic hyperandrogenemia, idiopathic hirsutism, adrenal hyperplasia due to 21-hydroxylase deficiency, androgen-secreting tumors, iatrogenic hirsutism, acromegaly, Cushing syndrome, hyperprolactinemia, and hypo- or hyperthyroidism. Read More

    Skin Manifestations of Insulin Resistance: From a Biochemical Stance to a Clinical Diagnosis and Management.
    Dermatol Ther (Heidelb) 2016 Dec 5. Epub 2016 Dec 5.
    Dermatology Division, Hospital Universitario "Dr. José E. González", Universidad Autónoma de Nuevo León, Monterrey, Mexico.
    Worldwide, more than 1.9 billion adults are overweight, and around 600 million people suffer from obesity. Similarly, ~382 million individuals live with diabetes, and 40-50% of the global population is labeled at "high risk" (i. Read More

    Cosmetics Use-Related Adverse Events and Determinants Among Jigjiga Town Residents, Eastern Ethiopia.
    Dermatol Ther (Heidelb) 2016 Nov 23. Epub 2016 Nov 23.
    Department of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
    Introduction: Non-medicated cosmetics use is very common among the Ethiopian population. However, little is known about these products' related adverse events. The aim of this study was to assess the prevalence and determinants of cosmetics-related adverse events among Jigjiga Town residents, Eastern Ethiopia. Read More

    Corticosteroid Injections: A Review of Sex-Related Side Effects.
    Orthopedics 2016 Nov 22:1-5. Epub 2016 Nov 22.
    Corticosteroid injections are used as a nonoperative modality to combat acute inflammation when conservative treatments fail. As female patients are regularly seen by orthopedic physicians, it is essential to identify and understand potential sex-related side effects. The aim of this article is to examine available literature for sex-related side effects of orthopedic-related corticosteroid injections. Read More

    Sleep Duration, Exercise, Shift Work and Polycystic Ovarian Syndrome-Related Outcomes in a Healthy Population: A Cross-Sectional Study.
    PLoS One 2016 21;11(11):e0167048. Epub 2016 Nov 21.
    Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore, 119228, Singapore.
    Context: Few studies have examined the associations between sleep duration, shiftwork, and exercise to the infrequent menstruation, hyperandrogenism, and ovarian morphological changes observed in women with polycystic ovarian syndrome (PCOS).

    Objective: To examine whether lifestyle factors, including short sleep duration, insufficient exercise, and shiftwork, alone or in combination, are associated with the reproductive and metabolic abnormalities typical of PCOS in a healthy population.

    Study Design, Size, Duration: Prospective cross-sectional study of 231 women, including healthcare workers recruited for an annual health screen, healthy referral patients from the Women's Clinic and volunteers from the university community at the National University Hospital, Singapore, from 2011 to 2015. Read More

    PARK2 Microduplication: Clinical and Molecular Characterization of a Further Case and Review of the Literature.
    Mol Syndromol 2016 Oct 2;7(5):282-286. Epub 2016 Sep 2.
    U.O.C. Malattie Metaboliche Genetica Medica, PO Giovanni XXIII, A.O.U. Policlinico Consorziale, Bari, Italy.
    We report on a patient with psychomotor deficits, language delay, dyspraxia, skeletal anomalies, and facial dysmorphisms (hirsutism, right palpebral ptosis, a bulbous nasal tip with enlarged and anteverted nares, and a mild prominent antihelix stem). Using high-resolution SNP array analysis, we identified a 0.49-Mb microduplication in chromosome 6q26 inherited from the mother involving the PARK2 gene: arr[hg19] 6q26(162,672,821-163,163,143)×3 mat. Read More

    Pregnancy luteoma: A rare case report.
    Int J Appl Basic Med Res 2016 Oct-Dec;6(4):282-283
    Department of Pathology, Government Medical College, Amritsar, Punjab, India.
    Pregnancy luteomas are rare, nonneoplastic lesions of the ovary thought to be caused by the hormonal effects of pregnancy. Most of these patients are asymptomatic with the ovarian enlargement being incidentally discovered during imaging or surgery. Some patients develop hirsutism or virilization during late pregnancy. Read More

    The Relationship Between Hearing Thresholds and Hyperandrogenism in Polycystic Ovary Syndrome.
    Med Sci Monit 2016 Nov 15;22:4380-4385. Epub 2016 Nov 15.
    Department of Obstetrics and Gynecology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
    BACKGROUND The purpose of our study was to investigate the association between polycystic ovary syndrome (PCOS) and hearing thresholds. MATERIAL AND METHODS Forty women diagnosed with PCOS (mean age, 24.33±6. Read More

    Noncontraceptive use of oral combined hormonal contraceptives in polycystic ovary syndrome-risks versus benefits.
    Fertil Steril 2016 Dec 3;106(7):1572-1579. Epub 2016 Nov 3.
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:
    The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. Read More

    [Cutaneous manifestations of metabolic syndrome].
    Hautarzt 2016 Dec;67(12):982-988
    SMZ Ost, Abteilung für Dermatologie, Donauspital, Langobardenstr. 122, 1220, Wien, Österreich.
    Background: Metabolic syndrome (MetS) is a cluster of risk factors which increase the risk of developing cardiovascular diseases and type II diabetes mellitus. High blood pressure, hyperglycemia, dyslipidemia, and central obesity are the main risk factors. While MetS is not a dermatological diagnosis per se, several cutaneous manifestations can serve as a clinical indicator for impending MetS and facilitate an early diagnosis and therapy in order to prevent its long-term sequelae. Read More

    Steroid Metabolomic Disease Signature of Nonsyndromic Childhood Obesity.
    J Clin Endocrinol Metab 2016 Nov 9;101(11):4329-4337. Epub 2016 Aug 9.
    Department of Pediatrics, Pediatric Endocrinology and Diabetes (A.G., E.M.-T.), School of Medicine in Katowice, Medical University of Silesia, 40752 Katowice, Poland; Bioinformatics Knowledge Unit (M.S.), Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion-Israel Institute of Technology, Haifa 31096, Israel; Steroid Research and Mass Spectrometry Unit (M.F.H., S.A.W.), Division of Pediatric Endocrinology and Diabetology, Center of Child and Adolescent Medicine, Justus Liebig University, 35392 Giessen, Germany; and Faculty of Medicine (Z.H.), Technion - Israel Institute of Technology, Haifa 31096, Israel.
    Context: The profile of urinary steroids as measured by gas chromatography-mass spectrometry defines a subject's "steroidal fingerprint."

    Objective: Here, we clustered steroidal fingerprints to characterize patients with nonsyndromic childhood obesity by "steroid metabolomic signatures."

    Hypothesis: Nonsyndromic obesity is a symptom of different diseases and conditions, some of them will have their own signature. Read More

    Comparison of two insulin sensitizers, metformin and myo-inositol, in women with polycystic ovary syndrome (PCOS).
    Gynecol Endocrinol 2017 Jan 3;33(1):39-42. Epub 2016 Nov 3.
    a Department of Obstetrics and Gynecology , University of Pisa , Pisa , Italy.
    Insulin resistance (IR) plays a pivotal role in PCOS. Insulin-sensitizer agents such as metformin and inositols have been shown to improve the endocrine and metabolic aspects of PCOS. The purpose of this study is to compare their effects on the clinical and metabolic features of the women with PCOS. Read More

    Normal Pubertal Development in Daughters of Women with PCOS: A Controlled Study.
    J Clin Endocrinol Metab 2016 Oct 25:jc20162707. Epub 2016 Oct 25.
    1 Department of Obstetrics and Gynecology, Penn State College of Medicine, Hershey, PA.
    Context: Daughters of women with polycystic ovary syndrome (PCOS) are thought to be at increased risk for developing stigmata of the syndrome, but the ontogeny during puberty is uncertain.

    Objective: To phenotype daughters (N = 76) of mothers with PCOS and daughters (N = 80) from control mothers for reproductive and metabolic parameters characteristic of PCOS.

    Design, Setting, And Participants: Matched Case/Control Study, Penn State Hershey Medical Center, Non-Hispanic, Caucasian girls age 4-17 INTERVENTION: Obtain birth history, biometric, ovarian ultrasounds, whole body DXA scan for body composition, 2 hour glucose challenged salivary insulin levels and two timed urinary collections (12 hours overnight and 3 hours AM) for gonadotropins and sex steroids. Read More

    Prescribing of cyproterone acetate/ethinylestradiol in UK general practice: a retrospective descriptive study using The Health Improvement Network.
    Contraception 2016 Oct 18. Epub 2016 Oct 18.
    Spanish Centre for Pharmacoepidemiologic Research, Madrid, Spain.
    Objective: To investigate prescribing patterns of cyproterone acetate/ethinylestradiol (CPA/EE) in the United Kingdom before and after the 2013 prescribing guidance.

    Study Design: We conducted a retrospective descriptive study in UK general practice. The study population included women with a first prescription (index date) for CPA/EE in The Health Improvement Network in 2011 (N=2760), 2012 (N=2923) and 2014 (N=2341). Read More

    [Woman 19-old with hirsutism, obesity and acanthosis nigricans].
    Pol Merkur Lekarski 2016 Sep;41(243):141-144
    Medical University of Warsaw, Poland: Student's Scientific Circle "Endocrinus", Department of Internal Medicine and Endocrinology.
    19-year-old hirsute woman with obesity, skin lesions with features of acanthosis nigricans around neck, armpits, thoracic cage and wrists escalating for couple of months, elevated testosterone and insulin plasma levels was admitted to hospital to perform diagnostic approach. The final diagnosis was hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR-AN syndrome), considered as a subtype of policystic ovary syndrome (PCOS) and impaired glucose tolerance. HAIR-AN is characterized by coexistence of: hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). Read More

    J Hypertens 2016 Sep;34 Suppl 1 - ISH 2016 Abstract Book:e366
    University of Alabama at Birmingham, U.S.A.
    Heart disease, stroke, and kidney failure are leading causes of death worldwide, and hypertension is a significant risk factor for each. Hypertension is less common in women, compared to men, in those younger than 45 years of age. This trend is reversed in those 65 years and older. Read More

    A 6.5 mb deletion at 3q24q25.2 narrows Wisconsin syndrome critical region to a 750 kb interval: A potential role for MBNLI.
    Am J Med Genet A 2017 Jan 18;173(1):280-284. Epub 2016 Oct 18.
    Unita' di Genetica Medica, A.O.U. Pisana, Ospedale S.Chiara, Pisa, Italy.
    We report on a patient with a 6.5 Mb interstitial de novo deletion in 3q24q25.2, characterized by array CGH. Read More

    "It's not very feminine to have a mustache": Experiences of Danish women with polycystic ovary syndrome.
    Health Care Women Int 2017 Feb 14;38(2):167-186. Epub 2016 Sep 14.
    a Department of Nutrition, Exercise, and Sports, Faculty of Science , University of Copenhagen , Copenhagen , Denmark.
    This article explores women's lived experiences with polycystic ovary syndrome (PCOS) on the basis of semistructured interviews with 21 Danish women. It provides insights about the problems that they experienced and how they coped with PCOS. The interviews revealed that they were highly influenced by society's femininity norms. Read More

    The evaluation of endothelial function and structure in hirsute patients in reproductive age.
    Eur J Obstet Gynecol Reprod Biol 2016 Nov 3;206:208-212. Epub 2016 Oct 3.
    Marmara University Hospital, Department of Internal Medicine, Fevzi Cakmak District, Muhsin Yazicioglu Street No. 10, Ust Kaynarca, Pendik, Istanbul, Turkey.
    Objective: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age.

    Study Design: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Read More

    Age related normogram for antral follicle count in general population and comparison with previous studies.
    Eur J Obstet Gynecol Reprod Biol 2016 Nov 20;206:120-124. Epub 2016 Sep 20.
    Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
    Objective: To construct antral follicle count (AFC) nomogram of general population for every age and to compare our data with previous studies to assess whether available AFC nomograms present any geographical inconsistency.

    Study Design: A prospective cross-sectional study was conducted to document AFC nomogram among women in 20-50 years with regular menstrual bleeding. Patients admitted with hirsutism, menstrual irregularity, diagnosis of current/history of endometrioma and hormonal drug use within the last 6 months were excluded. Read More

    DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects.
    Hum Pathol 2017 Jan 21;59:41-47. Epub 2016 Sep 21.
    Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki 0368562.
    Sertoli-Leydig cell tumors (SLCTs) are representative of androgenic ovarian tumors, and they show diverse histologic differentiation, including heterologous differentiation. Genetically, SLCTs are characterized by the presence of DICER1 mutations. In the present study, we analyzed the correlation between somatic DICER1 hotspot mutations and clinicopathological features in 10 ovarian SLCTs. Read More

    The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.
    Hum Reprod 2016 Dec 22;31(12):2841-2855. Epub 2016 Sep 22.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Hacettepe University, 06100, Sihhiye, Ankara, Turkey
    Study Question: What is the reported overall prevalence of polycystic ovary syndrome (PCOS) according to the criteria of the National Institutes of Health (NIH), Rotterdam or the Androgen Excess and PCOS Society (AE-PCOS Society)?

    Summary Answer: The reported overall prevalence of PCOS (95% CI) according to diagnostic criteria of the NIH, Rotterdam and the AE-PCOS Society is 6% (5-8%, n = 18 trials), 10% (8-13%, n = 15 trials) and 10% (7-13%, n = 10 trials), respectively.

    What Is Already Known: PCOS is the most common endocrine disorder among women of reproductive age. Although many studies have investigated the prevalence of PCOS, there are discrepancies in their results, in part due to the use of various definitions of the syndrome and its subphenotypes, differences between study cohorts, ethnicities, and types of recruitment and sampling. Read More

    Luteoma of Pregnancy Presenting with Severe Maternal Virilisation: A Case Report.
    Case Rep Obstet Gynecol 2016 31;2016:3523760. Epub 2016 Aug 31.
    Obstetrics and Gynecology Department, Ospedale Vittorio Emanuele-Policlinico-S. Bambino, 95123 Catania, Italy.
    Luteoma of pregnancy is a rare, benign condition characterized by a tumor-like mass of the ovary that emerges during pregnancy and regresses spontaneously after delivery. It is usually asymptomatic and the diagnosis is generally incidental. Luteoma arises from the proliferation of luteinised cell under the influence of β-hCG and can be hormonally active, with production of androgens resulting in maternal and fetal hirsutism and virilisation. Read More

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