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    Polycystic ovary syndrome, personality, and depression: A twin study.
    Psychoneuroendocrinology 2017 Aug 10;85:63-68. Epub 2017 Aug 10.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 77, Stockholm, Sweden; Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, 413 45, Gothenburg, Sweden.
    Background: Women with polycystic ovary syndrome (PCOS) are at elevated risk for suffering from depression. Neuroticism is a personality trait that has been associated with an increased risk for developing major depressive disorder (MDD). The aim of the present study was to quantify and decompose the correlation between neuroticism, PCOS, and MDD into shared and unique genetic and environmental etiologies, by using quantitative genetic methods. Read More

    A syndromic extreme insulin resistance caused by biallelic POC1A mutations in exon 10.
    Eur J Endocrinol 2017 Aug 17. Epub 2017 Aug 17.
    A Brusco, Medical Sciences, University of Torino, Torino, 10126, Italy
    POC1A encodes a protein with a role in centriole assembly and stability, and in ciliogenesis. Biallelic loss of function mutations affecting POC1A cause SOFT syndrome, an ultra-rare condition characterized by short stature, onychodysplasia, facial dysmorphism and hypotrichosis. Using exome sequencing, we identified a homozygous frameshift mutation (c. Read More

    Laser and Light Treatments for Hair Reduction in Fitzpatrick Skin Types IV-VI: A Comprehensive Review of the Literature.
    Am J Clin Dermatol 2017 Aug 8. Epub 2017 Aug 8.
    Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
    Unwanted facial and body hair presents as a common finding in many patients, such as females with hirsutism. With advances in laser and light technology, a clinically significant reduction in hair can be achieved in patients with light skin. However, in patients with darker skin, Fitzpatrick skin types (FST) IV-VI, the higher melanin content of the skin interferes with the proposed mechanism of laser-induced selective photothermolysis, which is to target the melanin in the hair follicle to cause permanent destruction of hair bulge stem cells. Read More

    Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome.
    Int J Adolesc Med Health 2017 Aug 5. Epub 2017 Aug 5.
    Background Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases. Objective The present study aimed to determine the prevalence of MS in 14-18-year-old girls. Methods This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). Read More

    Modified Ferriman-Gallwey Score in Hirsutism and its Association with Metabolic Syndrome.
    Int J Trichology 2017 Jan-Mar;9(1):7-13
    Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.
    Background: Hirsutism is the presence of terminal hair in females in males pattern. It occurs in 5%-15% of women. Modified Ferriman-Gallwey (mFG) score of ≥ 8 is considered hirsutism, but there are populations with a low mFG score. Read More

    Progesterone receptor modulators for endometriosis.
    Cochrane Database Syst Rev 2017 Jul 25;7:CD009881. Epub 2017 Jul 25.
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
    Background: Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. Read More

    [Hirsutism - etiopathogenesis, diagnostics and treatment].
    Cas Lek Cesk 2017 ;156(3):133-136
    Hirsutism is defined as excessive terminal hair growth in distribution typical for postpubertal men. It affects approximately 5-10 % of women and most frequently manifests in puberty. Significant cosmetic stigmatization is the usual complaint that brings patient to the doctor and it is crucial to always rule out any primary underlying disease causing hirsutism - benign or malignant. Read More

    Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia.
    Horm Res Paediatr 2017 Jul 14. Epub 2017 Jul 14.
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
    Background: Diazoxide is the first-line treatment for pediatric hyperinsulinemic hypoglycemia (HI). This study aimed to elucidate the pharmacokinetics of diazoxide in children with HI.

    Methods: We obtained 81 blood samples from 22 children with HI. Read More

    Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
    J Adolesc Health 2017 Jul 13. Epub 2017 Jul 13.
    Pediatric & Adolescent Endocrinology, Department of Development & Regeneration, University Hospital Gasthuisberg-University of Leuven, Leuven, Belgium.
    Purpose: Polycystic ovary syndrome (PCOS) is an increasingly prevalent disorder in adolescent girls, commonly presenting with hirsutism/oligomenorrhea, commonly treated with an oral contraceptive (OC), and commonly followed by oligoanovulatory subfertility. We tested whether an intervention targeting the reduction of hepato-visceral adiposity is followed by a higher ovulation rate than OC treatment.

    Methods: This randomized, open-label, single-center, pilot proof-of-concept study (12 months on treatment, then 12 months off) was performed in adolescent girls with hirsutism and oligomenorrhea (PCOS by National Institutes of Health; no sexual activity; N = 36; mean age 16 years, body mass index 23. Read More

    Do anabolic-androgenic steroids have performance-enhancing effects in female athletes?
    Mol Cell Endocrinol 2017 Jul 12. Epub 2017 Jul 12.
    Section of Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
    Doping with anabolic-androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from clinical trials of testosterone administration in non-athlete women suggests that AAS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported. Read More

    Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome.
    J Gynecol Obstet Hum Reprod 2017 Jul 8. Epub 2017 Jul 8.
    Female Fertility Clinic, Infertility Research Center of Hazrat-e Zahra, Shahrekord University of Medical Science, Shahrekord, Iran.
    Objective: To evaluate the effects of short- and long-term treatment with metformin and NAC, in an adjuvant to clomiphene citrate (CC), on the improvement of hormonal profile (SHBG, total testosterone, FBS, and fasting insulin) and fertility status in CC-resistant women with PCOS.

    Materials And Methods: One hundred and eight CC-resistant PCOS patients participated in the study and received either metformin (1500mg/day) or NAC (1800mg/day) with 100mg/day of CC for 8 and 12 weeks. Mean BMI, hirsutism score, LH/FSH ratio, endometrial thickness, mature follicle number, and serum concentrations of LH, FSH, E2, fasting insulin, total testosterone and FBS were evaluated before and after short- and long-term treatment. Read More

    Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height.
    J Pediatr Endocrinol Metab 2017 Jun 23. Epub 2017 Jun 23.
    Background: The clinical, laboratory, genetic properties and final height of a large cohort of patients with nonclassical 21-hydroxylase deficiency (NC21OHD) in Turkey were analyzed.

    Methods: This multicenter, nationwide web-based study collected data.

    Results: The mean age was 9. Read More

    In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature.
    J Pediatr Endocrinol Metab 2017 Jul;30(7):785-790
    Background: Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). Read More

    The effect of cutaneous prostaglandin application on nail growth, nail brittleness, and intraocular pressure.
    J Cosmet Dermatol 2017 Jul 6. Epub 2017 Jul 6.
    University of Illinois at Urbana-Champaign, Urbana, IL, USA.
    Background: Bimatoprost has known adnexal activity and was observed to increase nail growth at two clinical centers.

    Objectives: In this randomized, double-blinded, placebo-controlled pilot study, we examine the effect of bimatoprost (Lumigan 0.01%), applied bid to the proximal nail fold on nail growth, nail brittleness, and intraocular pressure. Read More

    Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height.
    J Pediatr Endocrinol Metab 2017 Jul;30(7):759-766
    Background: The clinical, laboratory, genetic properties and final height of a large cohort of patients with nonclassical 21-hydroxylase deficiency (NC21OHD) in Turkey were analyzed.

    Methods: This multicenter, nationwide web-based study collected data.

    Results: The mean age was 9. Read More

    Subclinical hypothyroidism does not influence the metabolic and hormonal profile of women with PCOS.
    Horm Mol Biol Clin Investig 2017 Jun 23. Epub 2017 Jun 23.
    Background Subclinical hypothyroidism (SCH) is present in 5%-10% of polycystic ovary syndrome (PCOS) patients. To date, its impact on the metabolic and hormonal profile of those women remains controversial. The purpose of our study is to evaluate the impact of SCH on the glycemic, lipid and hormonal profile of PCOS patients. Read More

    Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Biol Trace Elem Res 2017 Jul 1. Epub 2017 Jul 1.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
    Data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS) are scarce. The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress in women with PCOS. Sixty PCOS women were randomized into two groups and treated with 100 mg magnesium, 4 mg zinc, 400 mg calcium plus 200 IU vitamin D supplements (n = 30), or placebo (n = 30) twice a day for 12 weeks. Read More

    Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome.
    Clin Chim Acta 2017 Aug 15;471:243-247. Epub 2017 Jun 15.
    The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
    Background: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients.

    Methods: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study. Read More

    Familial partial lipodystrophy and proteinuric renal disease due to a missense c.1045C > T LMNA mutation.
    Endocrinol Diabetes Metab Case Rep 2017 2;2017. Epub 2017 Jun 2.
    Departments of Endocrinology.
    Proteinuric renal disease is prevalent in congenital or acquired forms of generalized lipodystrophy. In contrast, an association between familial partial lipodystrophy (FPLD) and renal disease has been documented in very few cases. A 22-year-old female patient presented with impaired glucose tolerance, hyperinsulinemia, hirsutism and oligomenorrhea. Read More

    Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome.
    J Res Med Sci 2017 30;22:64. Epub 2017 May 30.
    Department of Obstetrics and Gynecology, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with unknown etiology and with different complications. The aim of this study was to evaluate the effect of omega-3 supplementation on PCOS symptoms and metabolic syndrome.

    Materials And Methods: This double-blind clinical trial was performed in 2015 in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran, on 88 patients with PCOS. Read More

    Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling.
    Heliyon 2017 May 30;3(5):e00309. Epub 2017 May 30.
    Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
    Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage. Read More

    Severe hyperandrogenemia in postmenopausal woman as a presentation of ovarian hyperthecosis. Case report and mini review of the literature.
    Gynecol Endocrinol 2017 Jun 11:1-4. Epub 2017 Jun 11.
    a Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.
    Ovarian hyperthecosis (OH) is characterized by the presence of abundant luteinized theca cells in ovaries that secret androgen. It typically presents as severe hyperandrogenism and/or virilization in postmenopausal woman. Here we describe a 66-year old woman with presentation of severe hirsutism, alopecia, clitoromegaly and laboratory finding of significantly elevated serum total testosterone concentration and hyperinsulinemia. Read More

    Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women.
    Hum Reprod Update 2017 Jun 5:1-20. Epub 2017 Jun 5.
    Departments of Obstetrics/Gynecology, and Medicine, Augusta University, Augusta, GA, USA.
    Background: Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder characterized by androgen excess.

    Objective And Rationale: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of NCAH. A meta-analysis of epidemiological data was also performed. Read More

    Congenital adrenal hyperplasia.
    Lancet 2017 May 30. Epub 2017 May 30.
    National Institutes of Health Clinical Center, Bethesda, MD 20892, USA; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Electronic address:
    Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol biosynthesis. Depending on the type and severity of steroid block, patients can have various alterations in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement therapy. Presentations vary from neonatal salt wasting and atypical genitalia, to adult presentation of hirsutism and irregular menses. Read More

    Association between biochemical hyperandrogenism parameters and Ferriman-Gallwey score in patients with polycystic ovary syndrome: A systematic review and meta-regression analysis.
    Clin Endocrinol (Oxf) 2017 Sep 30;87(3):217-230. Epub 2017 Jun 30.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background And Objective: A limited number of studies have evaluated the relationship between clinical and biochemical hyperandrogenism (HA). This study aimed to evaluate the association between biochemical hyperandrogenism parameters (BHPs) and Ferriman-Gallwey (FG) score in patients with polycystic ovary syndrome (PCOS).

    Methods: We searched PubMed, Scopus, Google Scholar, ScienceDirect and Web of Sciences databases (2000-2015) to identify studies investigating clinical and biochemical parameters of HA in PCOS patients. Read More

    Efficacy of peeling during different periods of the menstrual cycle on acne.
    J Cosmet Laser Ther 2017 Jun 1:1-3. Epub 2017 Jun 1.
    a Department of Dermatology , Uludag University , Bursa , Turkey.
    Background And Design: The aim of this study was to investigate the efficacy of 50% glycolic acid peeling performed at different phases of menstruation on acne.

    Materials And Methods: This study included 30 patients with mild-to-moderate acne. Those with regular menstrual cycles and no history or laboratory evidence of hormonal pathology, hirsutism were selected. Read More

    Melatonin Treatment May Be Able to Restore Menstrual Cyclicity in Women With PCOS: A Pilot Study.
    Reprod Sci 2017 Jan 1:1933719117711262. Epub 2017 Jan 1.
    1 Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, Roma, Italy.
    The objective of the study was to investigate the effects of 6 months of melatonin administration on clinical, endocrine, and metabolic features of women affected by polycystic ovary syndrome (PCOS). This is a prospective cohort study including 40 normal-weight women with PCOS between January and September 2016, enrolled in an academic research environment. Ultrasonographic pelvic examinations, hirsutism score evaluation, hormonal profile assays, oral glucose tolerance test, and lipid profile at baseline and after 6 months of melatonin administration were performed. Read More

    Pathophysiology, diagnosis and treatment of polycystic ovary syndrome.
    Nurs Stand 2017 May;31(39):44-51
    School of Nursing and Midwifery, Queen's University Belfast, Belfast, Northern Ireland.
    Polycystic ovary syndrome (PCOS) is an incurable disorder that is associated with ovarian dysfunction. It affects millions of women in the UK. The signs and symptoms of PCOS include ovarian cysts, acne and excess hair growth (hirsutism), and can have a negative effect on the self-esteem of women with the condition. Read More

    The high-molecular weight multimer form of adiponectin is a useful marker of polycystic ovary syndrome in Bahraini Arab women.
    Clin Nutr ESPEN 2016 Jun 20;13:e33-e38. Epub 2016 Apr 20.
    Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. Electronic address:
    Background & Aims: We tested if decreased total and high molecular weight (HMW)-adiponectin, and altered HMW/total adiponectin ratio (HMWR) constitute reliable markers of polycystic ovary syndrome (PCOS) among Bahraini Arab women.

    Methods: Case-control study involving 122 Bahraini Arab women with PCOS and 89 ethnically-matched control women. PCOS was evaluated according to 2003 Rotterdam criteria. Read More

    Long-pulsed Nd: YAG Laser and Intense Pulse Light-755 nm for Idiopathic Facial Hirsutism: A Comparative Study.
    J Cutan Aesthet Surg 2017 Jan-Mar;10(1):40-44
    Department of Dermatology, Venereology and Leprosy, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
    Background: Hirsutism means excessive terminal hair growth in a female in male pattern distribution. Perception of hirsutism is subjective. Permanent laser hair reduction is a slow process taking many sessions and tracking of improvement parameters is tedious. Read More

    Understanding and supporting women with polycystic ovary syndrome: a qualitative study in an ethnically diverse UK sample.
    Endocr Connect 2017 Jul 17;6(5):323-330. Epub 2017 May 17.
    University of LeicesterDiabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK.
    Objective: Polycystic ovary syndrome (PCOS) is a lifelong condition. Its symptoms have been linked with psychological consequences, but less attention has been given to the daily implications of living with PCOS. We aimed to explore women's experiences living with PCOS, and the potential acceptability of group education sessions for this target group. Read More

    Reconstructing Discontinuous Facial Defects with Simultaneous Ulnar Perforator Free Flaps.
    Plast Reconstr Surg Glob Open 2017 Apr 7;5(4):e1291. Epub 2017 Apr 7.
    Department of Otolaryngology, University of Colorado School of Medicine, Aurora, Colo.; and Division of Plastic Surgery, Departments of Surgery and Otolaryngology, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colo.
    Multiple, simultaneous skin cancers of the face are common. This is the first description of reconstructing discontinuous facial defects (i.e. Read More

    Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome.
    Int J Womens Dermatol 2017 Mar 13;3(1):37-43. Epub 2017 Mar 13.
    Department of Dermatology, University of California, San Francisco, CA.
    Background: The complex interplay between ethnicity, Fitzpatrick skin type (FST), and hirsutism in patients with polycystic ovarian syndrome (PCOS) is poorly understood.

    Objective: In this cross-sectional, retrospective analysis, we examined the prevalence, severity, and distribution of hirsutism with clinician-rated site-specific and total modified Ferriman-Gallwey (mFG) visual scoring in a diverse cohort of American patients with PCOS.

    Methods: Independent analyses were conducted on the basis of patient-reported FST ratings and ethnicity. Read More

    Endocrine evaluation of hirsutism.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S6-S10. Epub 2017 Feb 16.
    University of Connecticut Medical Center, Department of Dermatology, Farmington, CT.
    Hirsutism is defined as excessive terminal hair growth in a male pattern in females. It typically affects 5 to 10% of reproductive-age women. Excessive hair growth can often cause significant psychological and emotional distress. Read More

    Prevalence of 'obesity-associated gonadal dysfunction' in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis.
    Hum Reprod Update 2017 Jul;23(4):390-408
    Department of Endocrinology and Metabolism, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, E-28034 Madrid, Spain.
    Background: Sexual dimorphism manifests noticeably in obesity-associated gonadal dysfunction. In women, obesity is associated with androgen excess disorders, mostly the polycystic ovary syndrome (PCOS), whereas androgen deficiency is frequently present in obese men in what has been termed as male obesity-associated secondary hypogonadism (MOSH). Obesity-associated gonadal dysfunction, consisting of PCOS in women and MOSH in men, is a frequent finding in patients with severe obesity and it may be ameliorated or even resolve with marked weight loss, especially after bariatric surgery. Read More

    11-Oxygenated Androgens Are Biomarkers of Adrenal Volume and Testicular Adrenal Rest Tumors in 21-Hydroxylase Deficiency.
    J Clin Endocrinol Metab 2017 Aug;102(8):2701-2710
    National Institutes of Health Clinical Center, Bethesda, Maryland 20892.
    Context: Patients with 21-hydroxylase deficiency (21OHD) have long-term complications, resulting from poor disease control and/or glucocorticoid overtreatment. Lack of optimal biomarkers has made it challenging to tailor therapy and predict long-term outcomes.

    Objective: To identify biomarkers of disease control and long-term complications in 21OHD. Read More

    Use of cyproterone acetate/ethinylestradiol in polycystic ovary syndrome: rationale and practical aspects.
    Eur J Contracept Reprod Health Care 2017 Jun 2;22(3):183-190. Epub 2017 May 2.
    a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
    Introduction: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age.

    Objectives: To review the present knowledge about PCOS and summarize the role of CPA/EE in the care of patients suffering from this condition for the practitioner. Read More

    Paratubal Cyst Size Correlates With Obesity and Dysregulation of the Wnt Signaling Pathway.
    J Pediatr Adolesc Gynecol 2017 Apr 27. Epub 2017 Apr 27.
    Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Urology, Baylor College of Medicine, Houston, Texas. Electronic address:
    Study Objective: Paratubal cysts (PTCs) occur in 7%-10% of women, regardless of age. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. The specific aims of the study were to determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from female adolescents. Read More

    Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility.
    Am J Obstet Gynecol 2017 Aug 26;217(2):191.e1-191.e19. Epub 2017 Apr 26.
    Department of Biostatistics, Yale University School of Public Health, New Haven, CT.
    Background: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed.

    Objective: The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. Read More

    Congenital Adrenal Hyperplasia.
    J Pediatr Adolesc Gynecol 2017 Apr 24. Epub 2017 Apr 24.
    Division of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh. Electronic address:
    The congenital adrenal hyperplasias (CAH) comprise a family of autosomal recessive disorders that disrupt adrenal steroidogenesis. The most common form is due to21-hydroxylase deficiency associated with mutations in the CYP21A2 gene which is located at chromosome 6p21. The clinical features associated with each disorder of adrenal steroidogenesis represent a clinical spectrum reflecting the consequences of the specific mutations. Read More

    The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review.
    Eur J Contracept Reprod Health Care 2017 Jun 27;22(3):172-182. Epub 2017 Apr 27.
    c Departamento de Ginecologia e Obstetrícia da UFMG , Belo Horizonte , Brazil.
    Introduction: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Read More

    [Calcium and bone metabolism across women's life stages. Bone metabolism and estrogen/androgen balance in women.]
    Clin Calcium 2017;27(5):673-682
    Department of Reproductive and Menopausal Medicine, Tokushima University Graduate School, Japan.
    Androgen as well as estrogen has physical, psychological and sexual roles in women. The action of androgen on bone health in women is important. The androgen receptor is expressed in osteoblasts and osteocytes but the mechanism has not been clarified in women. Read More

    Effects of supervised aerobic training on the levels of anti-Mullerian hormone and adiposity measures in women with normo-ovulatory and polycystic ovary syndrome.
    J Pak Med Assoc 2017 Apr;67(4):499-507
    Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, KSA.
    Objective: To evaluate the change in the levels of anti-Mullerian hormone, adiponectin, weight loss and fertility parameters in obese women with or without polycystic ovary syndrome, following 12 weeks of supervised aerobic exercise.

    Methods: This study was conducted from August 2013 to October 2014 among obese women with or without polycystic ovary syndrome referred to Obstetrics and Gynecology clinic, Mansoura University Hospital, Faculty of Medicine, Mansoura, Egypt. Patients were classified into three age-matched groups; group A had controls, group B had patients with polycystic ovary syndrome and group C had obese women. Read More

    A Case Report of Cushing's Disease Presenting as Hair Loss.
    Case Rep Dermatol 2017 Jan-Apr;9(1):45-50. Epub 2017 Feb 21.
    Department of Dermatology, Roger Williams Medical Center, Providence, RI, USA.
    Cushing's syndrome is a rare endocrine disorder that comprises a large group of signs and symptoms resulting from chronic exposure to excess corticosteroids. Most cases of Cushing's syndrome are due to increased adrenocorticotropic hormone production from a pituitary adenoma, which is referred to as Cushing's disease. Most of the signs and symptoms are nonspecific and common in the general population, making a diagnosis often challenging. Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Imatinib and spironolactone suppress hepcidin expression.
    Haematologica 2017 Jul 6;102(7):1173-1184. Epub 2017 Apr 6.
    Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg and Molecular Medicine Partnership Unit, Heidelberg, Germany
    Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis. Here, we investigated whether drugs targeting genetic regulators of hepcidin can affect iron homeostasis. We focused our efforts on drugs approved for clinical use to enable repositioning strategies and/or to reveal iron-related side effects of widely prescribed therapeutics. Read More

    Psychological distress, anger and quality of life in polycystic ovary syndrome: associations with biochemical, phenotypical andsocio-demographic factors.
    J Psychosom Obstet Gynaecol 2017 Apr 6:1-10. Epub 2017 Apr 6.
    b Reproductive Medicine Unit, San Paolo Hospital , University of Milan , Milan , Italy.
    Objective: To investigate the association between polycystic ovary syndrome (PCOS) and psychological disturbances, including anger. To analyze whether the biochemical/phenotypical features of PCOS play a role in the type and severity of psychological disorders.

    Material And Methods: This case-control study included 30 PCOS patients meeting NIH criteria and 30 non-PCOS women referring to Reproductive Medicine Unit for infertility. Read More

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