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Br J Dermatol 2020 Jun 1. Epub 2020 Jun 1.

Department of Anesthesiology, Duke University School of Medicine, Durham, NC, 27701, USA.

Epidermal growth factor receptor (EGFR) inhibitors are used to treat several malignancies but notoriously exert dermatologic toxicities, reducing patient adherence. Despite targeting the same receptor, different EGFR inhibitors exhibit distinct toxicities. Up to 90% of patients on EGFR inhibitors present with a papulopustular rash, with varying severity and frequency depending on the inhibitor. Read More

Endocrinol Diabetes Metab Case Rep 2020 Apr 12;2020. Epub 2020 Apr 12.

Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima, Peru.

Summary: Cushing's syndrome is an endocrine disorder that causes anovulatory infertility secondary to hypercortisolism; therefore, pregnancy rarely occurs during its course. We present the case of a 24-year-old, 16-week pregnant female with a 10-month history of unintentional weight gain, dorsal gibbus, nonpruritic comedones, hirsutism and hair loss. Initial biochemical, hormonal and ultrasound investigations revealed hypokalemia, increased nocturnal cortisolemia and a right adrenal mass. Read More

J Affect Disord 2020 May 22;274:205-209. Epub 2020 May 22.

College of Applied Sciences, Al Maarefa University, Riyadh, Saudi Arabia.

Background: While increased risk of psychiatric burden in patients with polycystic ovarian syndrome (PCOS) is reported in the literature, there is dearth of reports from Saudi Arabia on occurrence of psychological burden in women with PCOS. This study aimed to compare the sociodemographic and clinical features of PCOS cases with non-PCOS control and explore the prevalence of depression, anxiety and stress in PCOS and non-PCOS women.

Materials And Methods: This is a case-control study carried out in PSMMC, Riyadh, Saudi Arabia from March 2019 to June 2019. Read More

J Obstet Gynaecol Res 2020 May 27. Epub 2020 May 27.

Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.

We report a rare case of an ovarian steroid cell tumor with a diagnosis prompted by heart failure symptoms. A 28-year-old Japanese nulligravida/nullipara with a chief complaint of respiratory discomfort during physical exertion and exhibiting heart failure symptoms was referred to our hospital. She also had signs of virilization, including secondary menorrhea since the age of 20, hirsutism and balding. Read More

J Pediatr Endocrinol Metab 2020 May 24. Epub 2020 May 24.

Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100853, China.

Objectives Sanfilippo syndrome (Mucopolysaccharidosis III, MPS III) is a rare autosomal recessive hereditary disease, which is caused by lysosomal enzyme deficiency. This study was operated to investigate clinical and molecular characteristics of patients with MPS III, which will improve the diagnosis and treatment of MPS III. Method Thirty four patients with MPS III were assessed using clinical evaluation, questionnaire, and scoring system. Read More

J Clin Endocrinol Metab 2020 May 22. Epub 2020 May 22.

Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California.

Context: Epidemiologic studies of polycystic ovary syndrome (PCOS) are limited, especially in populations where diagnostic resources are less available. In these setting, an accurate, low-cost screening tool would be invaluable.

Objective: To test the use of a simple questionnaire to identify women at increased risk for PCOS and androgen excess (AE) disorders. Read More

J Pediatr Endocrinol Metab 2020 May 22. Epub 2020 May 22.

King's College Hospital NHS Foundation Trust, London, UK.

Background Inherited severe insulin resistance syndromes (SIRS) are rare and can be caused by mutations in the insulin receptor gene (INSR). Case presentation A 12-year-old Jamaican girl with a BMI of 24.4 kg/m2 presented with polyuria and polydipsia. Read More

Arch Gynecol Obstet 2020 Jul 19;302(1):203-208. Epub 2020 May 19.

International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: To report the clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients with Sertoli-Leydig cell tumors (SLCTs) of ovary.

Methods: 13 patients with pathologically confirmed ovarian SLCTs at International Peace Maternity and Child Health Hospital from 2010 and 2019 were included in this study. The clinical, ultrasound and histopathological characteristics, clinical management, and prognosis of 13 patients were retrospectively analyzed. Read More

Clin Cosmet Investig Dermatol 2020 24;13:319-324. Epub 2020 Apr 24.

Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.

Purpose: Hirsutism (ie, terminal hair growth on the face and body in a male-like pattern in women) is a common dermatological disorder in women, with psychosocial implications. Consequently, there is demand for finding novel pharmacological treatments and agents that can safely reduce hair growth. This study aimed to investigate the potential effect of topical acyclovir on hair growth in mice. Read More

Horm Metab Res 2020 May 18. Epub 2020 May 18.

Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, AL, USA.

This systematic review aims to evaluate all epidemiological evidence in the literature linking the effect of vitamin D supplementation to metabolic and hormonal functions in women with polycystic ovary syndrome. The literature search was performed with two databases, namely Medline/PubMed and Web of Science, until 20 May 2019 for both observational and experimental studies concerning relationships between vitamin D and polycystic ovary syndrome. A total of ten studies with randomized, double-blinded, and placebo-controlled trial design from 2008 to 2019 were selected for this review. Read More

Minerva Pediatr 2020 May 15. Epub 2020 May 15.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Hospital Trust of Verona, Verona, Italy.

Polycystic ovary syndrome (PCOS) is the most frequent endocrine disorder in women and it is associated with an increased rate of infertility. Its etiology remains largely unknown, although both genetic and environmental factors play a role. PCOS is characterized by insulin resistance, metabolic disorders and low-grade chronic inflammation. Read More

Biomolecules 2020 May 13;10(5). Epub 2020 May 13.

Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA.

Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and complications of cirrhosis by antagonizing the mineralocorticoid receptor. However, SP also antagonizes the androgen receptor, and thus SP has also been shown to be effective in the treatment of acne, hair loss, and hirsutism in women. Interestingly, recent drug repurposing screens have identified new and diverse functions for SP as a simulator of tumor immunosurveillance and as an inhibitor of DNA repair and viral infection. Read More

Front Oncol 2020 28;10:574. Epub 2020 Apr 28.

Department of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Ectopic ACTH syndrome is rare in pediatric age. Sarcomas that cause Ectopic ACTH Syndrome (EAS) are even more uncommon. Currently, only three cases of EAS caused by Ewing' sarcoma have been reported. Read More

Curr Pharm Des 2020 May 15. Epub 2020 May 15.

University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur, 492010 (C.G.). India.

The pilosebaceous unit is the triad comprising of hair follicle, arrector pilli muscle, and sebaceous gland. Drug delivery to and through the hair follicles has garnered much attention of the researchers and the hair follicles represent an attractive target site via topical applications. They are bordered by capillaries and antigen-presenting cells, connected to the sebaceous glands and the bulge region of the hair follicle anchors the stem cells. Read More

Actas Dermosifiliogr 2020 May 11. Epub 2020 May 11.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Oral contraceptives combine estrogen and progesterone to suppress ovulation. Synthetic forms are usually used. In dermatology, oral contraceptives are prescribed for 2 main reasons: to prevent pregnancy when teratogenic drugs must be taken and to treat skin manifestations of hyperandrogenism. Read More

Dermatol Pract Concept 2020 20;10(2):e2020048. Epub 2020 Apr 20.

Department of Dermatology, STD & Leprosy, Government Medical College, Srinagar, India.

Unwanted hair growth, which is a common aesthetic problem, has traditionally been treated using various techniques such as shaving, waxing, and epilation, but most of these provide only a temporary solution. Laser and light-based technology for hair removal has become one of the fastest growing procedures in modern cosmetic dermatology in the last decade. Clinical experience suggests that in the ideal subject with fair skin and dark hair, laser treatment can reduce hair growth significantly. Read More

Case Rep Oncol 2020 Jan-Apr;13(1):358-364. Epub 2020 Apr 2.

Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan.

We report a case of a 4-year-old girl with an ovarian steroid cell tumor, not otherwise specified (SCT-NOS). She was admitted to the hospital with progressing virilization and Cushing's syndrome, which included abnormality of the perineum, hirsutism, hypertrichosis, flushing of face, hoarseness, and weight gain. Blood testing showed a significantly increased testosterone level and slightly increased cortisol level. Read More

Saudi J Biol Sci 2020 May 16;27(5):1271-1279. Epub 2020 Jan 16.

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

The pathophysiology of polycystic ovary syndrome (PCOS) is confusing until today as it is a multifactorial endocrine disorder. It is presented with altered gonadotropin levels, bulky multi-follicular ovaries, infertility, and obesity. This complex pathophysiology is linked with insulin resistance and hyperandrogenism. Read More

Acta Obstet Gynecol Scand 2020 Apr 25. Epub 2020 Apr 25.

Department of Obstetrics and Gynecology, Medical Research Center Oulu and PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, Oulu, Finland.

Introduction: The aim of the study was to determine the association of body mass index (BMI), self-reported symptoms or diagnosis of polycystic ovary syndrome (PCOS), and hyperandrogenemia with the occurrence of gestational diabetes mellitus (GDM) through reproductive life.

Material And Methods: A cohort of women born in 1966 were investigated at ages 14, 31 and 46. Women with self-reported PCOS symptoms (presence of both oligo-amenorrhea and hirsutism) at age 31 or with formally diagnosed polycystic ovaries (PCO)/PCOS by age 46 formed the group of self-reported PCOS (srPCOS, n = 222) and were compared with women without self-reported PCOS symptoms or diagnosis (n = 1357). Read More

Case Rep Pediatr 2020 8;2020:6482938. Epub 2020 Apr 8.

Universidad Francisco Marroquín School of Medicine, Guatemala City 01010, Guatemala.

Cornelia de Lange syndrome (CdLS) is a rare syndromic genetic disorder characterized by multiple congenital anomalies with upper limb reduction defects, along with cardiac, gastrointestinal, and genitourinary defects. It is caused by genetic variations in the chromatin regulator genes, most commonly, the cohesin complex. Even though molecular genetic testing is highly recommended to confirm the diagnosis, high costs and unavailability in some settings are significant setbacks, and clinical criteria could be used. Read More

Case Rep Oncol Med 2020 8;2020:6970823. Epub 2020 Apr 8.

Endocrinology Department, Hedi Chaker Hospital, 3029 Sfax, Tunisia.

Steroid cell tumors (SCTs) (not otherwise specified (NOS)) are rare sex cord-stromal tumors of the ovary. These are associated with hormonal disturbances resulting in menstrual bleeding patterns and androgenic effects. We report the case of a 36-year-old female presented with hirsutism, signs of virilization, and elevated androgen levels. Read More

J Am Acad Dermatol 2020 Apr 19. Epub 2020 Apr 19.

Dermatology Department, Trichology Unit, Ramon y Cajal University Hospital, Madrid, Spain; Trichology Unit, Grupo de Dermatología Pedro Jaen, Madrid, Spain.

Contemp Clin Dent 2019 Jul-Sep;10(3):498-501

Department of Periodontology, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth (SBV), Deemed to be University, Puducherry, India.

Background: Periodontitis is associated with various systemic diseases one of which is poly cystic ovarian syndrome (PCOS). PCOS is a genetically complex endocrinopathy of uncertain etiology affecting women of the reproductive age group which results in the most common cause of anovulatory infertility, menstrual dysfunction, and hirsutism. PCOS has a close association with cardiometabolic risk profile, insulin resistance (IR), hyperinsulinemia, central obesity, dyslipidemia, and increasing the prevalence of cardiovascular risk factors. Read More

Heliyon 2020 Apr 6;6(4):e03746. Epub 2020 Apr 6.

Department of Pathology, Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan, China.

Among several types of ovarian tumors, Sertoli-Leydig cell tumors are considered significantly rare, accounting for less than 1% of all primary ovarian tumors. Hirsutism caused by ovarian tumors accounts for approximately 1% of all cases of hirsutism. We report a case of a woman with a ovarian Sertoli-Leydig cell tumor who presented with hirsutism. Read More

Nurs Womens Health 2020 Apr;24(2):115-126

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy, affecting as many as 5% to 20% of women of reproductive age, depending on the diagnostic criteria applied. Features of PCOS include physiologic anovulation, hyperandrogenism, elevated luteinizing hormone, and increased gonadotropin-releasing hormone pulse frequency, which often manifest physically as acne and hirsutism. The clinical presentation of PCOS often mimics normal pubertal physiologic development, which may delay diagnosis and treatment of the condition in adolescent girls. Read More

Horm Metab Res 2020 Apr 8;52(4):252. Epub 2020 Apr 8.

Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.

Dear Editor,We thank Kunicki et al. 1 for their interest in our paper 2 and for taking the time to give relevant and important comments regarding the inclusion of hirsutism or hyperandrogenism cases in our study. We agree with Kunicki et al. Read More

Dermatol Res Pract 2020 24;2020:7019126. Epub 2020 Mar 24.

Pristine Hospital and Research Centre, Bengaluru 560086, India.

Myo-inositol's role in improving acne by reducing hyperandrogenism has been demonstrated in PCOS patients. Inositol and associated molecules display inhibitory properties against 5- reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. However, the role of myo-inositol is not well established in women patients with normal hormone levels but with clinical manifestations of PCOS. Read More

BMC Med 2020 Mar 24;18(1):72. Epub 2020 Mar 24.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University and Monash Health, Melbourne, VIC, Australia.

Background: Diagnosing polycystic ovary syndrome (PCOS) during adolescence is challenging because features of normal pubertal development overlap with adult diagnostic criteria. The international evidence-based PCOS Guideline aimed to promote accurate and timely diagnosis, to optimise consistent care, and to improve health outcomes for adolescents and women with PCOS.

Methods: International healthcare professionals, evidence synthesis teams and consumers informed the priorities, reviewed published data and synthesised the recommendations for the Guideline. Read More

Eur J Obstet Gynecol Reprod Biol 2020 May 6;248:137-143. Epub 2020 Mar 6.

Department of Obstetrics and Gynecology, Boston University School of Medicine, 85 East Concord Street, Boston MA 02118, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, 200 Longwood Avenue, Boston, MA 02115, USA.

Objective: Hirsutism, the presence of excess terminal hair in a male pattern, is a clinical marker of androgen excess in women. We used cross-sectional data from a North American preconception cohort study to evaluate the association between menstrual cycle characteristics and hirsutism.

Study Design: Women aged 21-45 years were recruited to a North American cohort of pregnancy planners. Read More

Medicine (Baltimore) 2020 Mar;99(12):e19427

Obstetrics and Gynecology Unit, Torrecárdenas University Hospital, Almería.

Background: Severe and morbid obesity are increasing globally, particularly in women. As BMI increases, the likelihood of anovulation is higher. The primary aim of the EMOVAR clinical trial is to examine, over the short (16 weeks) and medium (12 months) term, the effects of a supervised physical exercise program (focused primarily on aerobic and resistance training) on ovarian function in women with severe/morbid obesity who have undergone bariatric surgery. Read More

Urol Case Rep 2020 Jul 26;31:101148. Epub 2020 Feb 26.

Division of Urology, UConn Health, 263 Farmington Avenue, Farmington, CT, 06030-8073, USA.

Androgen-secreting adrenal neoplasms have a low incidence, usually secrete multiple hormones, and may present with hirsutism, acne, and alopecia. We report an exceedingly rare case of a purely dehydroepiandrosterone-sulfate (DHEA-S) secreting adrenal neoplasm found incidentally on cross sectional imaging. The clinical, biochemical, and pathologic findings of this neoplasm are described. Read More

Fertil Steril 2020 Mar;113(3):636-641

Department of Biostatistics, Yale University School of Public Health, New Haven, Connecticut.

Objective: To determine whether biochemical or clinical markers of androgenic activity predict live birth rate with ovarian stimulation in the unexplained infertility population.

Design: Secondary analysis of the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) clinical trial.

Setting: Multicenter university-based clinical practices. Read More

Cureus 2020 Feb 3;12(2):e6855. Epub 2020 Feb 3.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Polycystic ovary syndrome (PCOS) commonly occurs in reproductive-age females. It elevates the hormonal levels, creates an imbalance in the metabolic system, and affects their reproductive system too. A number of studies have been conducted on PCOS, and it has been diagnosed together with several dermatological conditions. Read More

Gynecol Endocrinol 2020 Mar 16:1-4. Epub 2020 Mar 16.

Unité d'Endocrinologie-Gynécologie Pédiatrique, Département de Pédiatrie, Hôpital A.-de-Villeneuve, CHU Montpellier et Université Montpellier, Montpellier, France.

Hyperandrogenism is frequent and under investigated in adolescent girls. A 15-year-6-month-old French girl presented with oligomenorrhea and slowly progressing virilization 2 years post-menarche. Medical history revealed prenatal pesticide exposure through maternal professional activity and recurrent premature thelarche. Read More

J Endocrinol Invest 2020 Mar 12. Epub 2020 Mar 12.

Department of Endocrinology, Medical Faculty, Erciyes University, Kayseri, Turkey.

Purpose: The study aimed to investigate whether repeat number in the androgen receptor (AR) gene has any contribution to phenotypes of the disease of androgen excess (polycystic ovary syndrome (PCOS), idiopathic hyperandrogenemia (IHA) and idiopathic hirsutism (IH) in a cohort of Turkish women.

Methods: Three hundred and fifty-four voluntary premenopausal women (172 healthy controls and 182 patients with androgen excess disorders and idiopathic hirsutism) 18-45 years of age seen at an outpatient endocrine clinic at Erciyes University Hospital between January 2013 and December 2014 were included. All volunteers have undergone physical examination and biochemical evaluation. Read More

Arch Dermatol Res 2020 Mar 12. Epub 2020 Mar 12.

Department of Dermatology, Zealand University Hospital, Sygehusvej 5, 4000, Roskilde, Denmark.

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Read More

Am J Med Genet A 2020 May 3;182(5):953-956. Epub 2020 Mar 3.

Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, India.

Wiedemann-Steiner syndrome (WWS) is a rare disorder characterized by hypotonia, postnatal growth restriction, striking facial dysmorphism, and hirsutism. It is caused by heterozygous pathogenic variants in KMT2A. This gene has an established role in histone methylation, which explains the overlap of WWS with syndromes caused by genes involved in chromatin remodeling. Read More

Biol Trace Elem Res 2020 Mar 2. Epub 2020 Mar 2.

Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Medical School, 06610, Ankara, Turkey.

Zinc has shown to have an anti-androgenic effect through 5 alpha-reductase enzyme activity inhibition in skin. However, there are contradicting findings concerning the effect of zinc on hirsutism mainly from studies including adult women with polycystic ovary syndrome (PCOS). The aim of our study was to investigate the association between serum zinc levels and hirsutism in adolescents. Read More

Ceylon Med J 2019 Sep;64(3):111-117

University of Peradeniya,

Introduction: Visceral adiposity index (VAI) is a mathematical index derived from the body mass index (BMI), waist circumference (WC), serum fasting triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C). It reflects visceral adipocyte dysfunction (VAD) and is associated with cardiometabolic risk. Women with polycystic ovarian syndrome (PCOS) have adipocyte dysfunction, which is associated with metabolic disorders. Read More

Fertil Steril 2020 Feb;113(2):435-443

Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address:

Objective: To study the associations between maternal polycystic ovary syndrome (PCOS) and hirsutism with offspring attention-deficit/hyperactivity disorder (ADHD), anxiety, conduct disorder, and behavioral problems.

Design: Prospective birth cohort study.

Setting: Not applicable. Read More

J Clin Orthop Trauma 2020 Mar-Apr;11(2):307-309. Epub 2019 Apr 6.

Tepecik Training and Research Hospital, Department of Orthopaedics and Traumatology, İzmir, Turkey.

Cornelia de Lange syndrome is a genetic disorder with multiple system abnormalities. It is especially characterized by typical facial appearance and hirsutism. Growth and mental retardation, gastrointestinal, cardiovascular, and orthopedic abnormalities are other important features of this syndrome. Read More

Obes Surg 2020 Jun;30(6):2294-2300

Department of Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

There is limited data on the impact of bariatric surgery on polycystic ovarian syndrome (PCOS) especially in the Indian population.

Background: To study the impact of bariatric surgery in women with PCOS in terms of clinical, hormonal, and radiological aspects of polycystic ovarian syndrome.

Methods: A prospective observational study of 50 women who underwent bariatric surgery at our tertiary care center. Read More

J Sex Res 2020 Feb 20:1-13. Epub 2020 Feb 20.

Department of Psychology, Lakehead University.

Symptoms of polycystic ovary syndrome (PCOS) exist on a continuum, are associated with hyperandrogenism, and have fertility implications. The present study investigated the relationship between PCOS symptoms and sociosexuality in young women with a continuum of symptoms ranging from none to clinical levels. Given that unrestricted sociosexuality, or one's orientation toward uncommitted sexual activity, is associated with hyperandrogenism, we hypothesized that women experiencing more symptoms of PCOS, and a greater likelihood of androgen excess, would have a more unrestricted sociosexual orientation. Read More

J Cosmet Laser Ther 2020 Feb 14;22(2):65-69. Epub 2020 Feb 14.

Skin & V.D, King Edward Memorial Hospital Pune, Pune, India.

: Various light based technologies like Diode, long pulsed Nd:Yag and Intense Pulsed Light are used commonly for long-term hair reduction. The commonest indication is hirsutism.: 1. Read More

BMC Med Genet 2020 02 12;21(1):30. Epub 2020 Feb 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo, 08, Sri Lanka.

Background: PCOS is a common disorder of women due to genetic, endocrine and environmental effects that manifests from puberty. The rs9939609 variant of fat mass and obesity associated (FTO) gene is linked to metabolic derangement in PCOS. We previously identified FTO (rs9939609) as a susceptibility locus for PCOS among Sri Lankan women and also explored the role of kisspeptin. Read More

Taiwan J Obstet Gynecol 2020 Jan;59(1):79-84

Yıldırım Beyazıt University Faculty of Medicine, Department of Biochemistry, Ankara, Turkey.

Objective: Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women of reproductive age characterized by irregular menstruation and hirsutism and is associated with an increased risk for cardiovascular diseases. Increased inflammatory response and oxidative stress may also present in these patients. In this study, we aimed to compare the neutrophil-to-lymphocyte ratio (NLR), mean platelet volume (MPV), and dynamic thiol-disulphide homeostasis (dTDH) between the patients with PCOS and healthy individuals and to investigate the correlation between these parameters and cardiovascular risk factors in patients with PCOS. Read More

Skin Appendage Disord 2020 Jan 11;6(1):41-43. Epub 2019 Sep 11.

Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.

Autologous fat grafting (AFG) is a common procedure, which gains popularity for a large number of indications, mainly for reshaping and filling of contour defects. It is considered a safe procedure, with only uncommon and mild complications. Here we report on a 60-year-old female patient who developed excess hair growth on both cheeks 1 month following facial AFG done in conjunction with a facelift. Read More

J Clin Res Pediatr Endocrinol 2020 Feb 5. Epub 2020 Feb 5.

Marmara University Faculty of Medicine, Department of Medical Genetics, İstanbul, Turkey

Insulin receptor mutations lead to heterogeneous disorders; as severe as Donohue syndrome or as mild as “type A insulin resistance syndrome”. Patients with severe disorders are homozygous or compound heterozygous mutations. Generally patients with type A insulin resistance syndrome have been found to be heterozygous mutations, homozygous type mutations may rarely be responsible for this disease. Read More