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    Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome.
    Clin Chim Acta 2017 Jun 15;471:243-247. Epub 2017 Jun 15.
    The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
    Background: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients.

    Methods: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study. Read More

    Familial partial lipodystrophy and proteinuric renal disease due to a missense c.1045C > T LMNA mutation.
    Endocrinol Diabetes Metab Case Rep 2017 2;2017. Epub 2017 Jun 2.
    Departments of Endocrinology.
    Proteinuric renal disease is prevalent in congenital or acquired forms of generalized lipodystrophy. In contrast, an association between familial partial lipodystrophy (FPLD) and renal disease has been documented in very few cases. A 22-year-old female patient presented with impaired glucose tolerance, hyperinsulinemia, hirsutism and oligomenorrhea. Read More

    Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome.
    J Res Med Sci 2017 30;22:64. Epub 2017 May 30.
    Department of Obstetrics and Gynecology, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder with unknown etiology and with different complications. The aim of this study was to evaluate the effect of omega-3 supplementation on PCOS symptoms and metabolic syndrome.

    Materials And Methods: This double-blind clinical trial was performed in 2015 in Alzahra and Shahid Beheshti Hospitals, Isfahan, Iran, on 88 patients with PCOS. Read More

    Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling.
    Heliyon 2017 May 30;3(5):e00309. Epub 2017 May 30.
    Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
    Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whether the wound healing-associated signaling milieu can be manipulated to protect against alopecia, such as chemotherapy-induced alopecia (CIA). Utilizing a well-established neonatal rat model of CIA, we show here that skin wounding protects from alopecia caused by several clinically relevant chemotherapeutic regimens, and that protection is dependent on the time of wounding and hair cycle stage. Read More

    Severe hyperandrogenemia in postmenopausal woman as a presentation of ovarian hyperthecosis. Case report and mini review of the literature.
    Gynecol Endocrinol 2017 Jun 11:1-4. Epub 2017 Jun 11.
    a Department of Gynecological Endocrinology , Poznan University of Medical Sciences , Poznan , Poland.
    Ovarian hyperthecosis (OH) is characterized by the presence of abundant luteinized theca cells in ovaries that secret androgen. It typically presents as severe hyperandrogenism and/or virilization in postmenopausal woman. Here we describe a 66-year old woman with presentation of severe hirsutism, alopecia, clitoromegaly and laboratory finding of significantly elevated serum total testosterone concentration and hyperinsulinemia. Read More

    Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women.
    Hum Reprod Update 2017 Jun 5:1-20. Epub 2017 Jun 5.
    Departments of Obstetrics/Gynecology, and Medicine, Augusta University, Augusta, GA, USA.
    Background: Non-classic congenital hyperplasia (NCAH) due to 21-hydroxylase deficiency is a common autosomal recessive disorder characterized by androgen excess.

    Objective And Rationale: We conducted a systematic review and critical assessment of the available evidence pertaining to the epidemiology, pathophysiology, diagnosis and management of NCAH. A meta-analysis of epidemiological data was also performed. Read More

    Congenital adrenal hyperplasia.
    Lancet 2017 May 30. Epub 2017 May 30.
    National Institutes of Health Clinical Center, Bethesda, MD 20892, USA; The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. Electronic address:
    Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol biosynthesis. Depending on the type and severity of steroid block, patients can have various alterations in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement therapy. Presentations vary from neonatal salt wasting and atypical genitalia, to adult presentation of hirsutism and irregular menses. Read More

    Association between biochemical hyperandrogenism parameters and Ferriman-Gallwey score in patients with polycystic ovary syndrome: a systematic review and meta-regression analysis.
    Clin Endocrinol (Oxf) 2017 Jun 2. Epub 2017 Jun 2.
    Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background And Objective: A limited number of studies have evaluated the relationship between clinical and biochemical hyperandrogenism (HA). This study aimed to evaluate the association between biochemical hyperandrogenism parameters (BHPs) and Ferriman-Gallwey (FG) score in patients with polycystic ovary syndrome (PCOS).

    Methods: We searched PubMed, Scopus, Google Scholar, ScienceDirect and Web of Sciences databases (2000 to 2015) to identify studies investigating clinical and biochemical parameters of HA in PCOS patients. Read More

    Safety and Efficacy of Peeling During Different Periods of the Menstrual Cycle on Acne.
    J Cosmet Laser Ther 2017 Jun 1. Epub 2017 Jun 1.
    a Dermatology , Uludag University , bursa , Turkey.
    Background And Design: The aim of this study was to investigate the efficacy of 50% glycolic acid peeling performed at different phases of menstruation on acne.

    Material And Method: This study included 30 patient with mild to moderate acne. Those with regular menstrual cycles and no history or laboratory evidence of hormonal pathology, hirsutism were selected. Read More

    Melatonin Treatment May Be Able to Restore Menstrual Cyclicity in Women With PCOS: A Pilot Study.
    Reprod Sci 2017 Jan 1:1933719117711262. Epub 2017 Jan 1.
    1 Department of Obstetrics and Gynaecology, Università Cattolica del Sacro Cuore, Roma, Italy.
    The objective of the study was to investigate the effects of 6 months of melatonin administration on clinical, endocrine, and metabolic features of women affected by polycystic ovary syndrome (PCOS). This is a prospective cohort study including 40 normal-weight women with PCOS between January and September 2016, enrolled in an academic research environment. Ultrasonographic pelvic examinations, hirsutism score evaluation, hormonal profile assays, oral glucose tolerance test, and lipid profile at baseline and after 6 months of melatonin administration were performed. Read More

    Pathophysiology, diagnosis and treatment of polycystic ovary syndrome.
    Nurs Stand 2017 May;31(39):44-51
    School of Nursing and Midwifery, Queen's University Belfast, Belfast, Northern Ireland.
    Polycystic ovary syndrome (PCOS) is an incurable disorder that is associated with ovarian dysfunction. It affects millions of women in the UK. The signs and symptoms of PCOS include ovarian cysts, acne and excess hair growth (hirsutism), and can have a negative effect on the self-esteem of women with the condition. Read More

    The high-molecular weight multimer form of adiponectin is a useful marker of polycystic ovary syndrome in Bahraini Arab women.
    Clin Nutr ESPEN 2016 Jun 20;13:e33-e38. Epub 2016 Apr 20.
    Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. Electronic address:
    Background & Aims: We tested if decreased total and high molecular weight (HMW)-adiponectin, and altered HMW/total adiponectin ratio (HMWR) constitute reliable markers of polycystic ovary syndrome (PCOS) among Bahraini Arab women.

    Methods: Case-control study involving 122 Bahraini Arab women with PCOS and 89 ethnically-matched control women. PCOS was evaluated according to 2003 Rotterdam criteria. Read More

    Long-pulsed Nd: YAG Laser and Intense Pulse Light-755 nm for Idiopathic Facial Hirsutism: A Comparative Study.
    J Cutan Aesthet Surg 2017 Jan-Mar;10(1):40-44
    Department of Dermatology, Venereology and Leprosy, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.
    Background: Hirsutism means excessive terminal hair growth in a female in male pattern distribution. Perception of hirsutism is subjective. Permanent laser hair reduction is a slow process taking many sessions and tracking of improvement parameters is tedious. Read More

    Views of women with polycystic ovary syndrome: a qualitative study in an ethnically diverse sample.
    Endocr Connect 2017 May 17. Epub 2017 May 17.
    M Stone, Diabetes Research Centre, University of Leicester, Leicester, United Kingdom of Great Britain and Northern Ireland.
    Objective: Polycystic ovary syndrome (PCOS) is a lifelong condition. Its symptoms have been linked with psychological consequences, but less attention has been given to the daily implications of living with PCOS. We aimed to explore women's experiences living with PCOS, and the potential acceptability of group education sessions for this target group. Read More

    Reconstructing Discontinuous Facial Defects with Simultaneous Ulnar Perforator Free Flaps.
    Plast Reconstr Surg Glob Open 2017 Apr 7;5(4):e1291. Epub 2017 Apr 7.
    Department of Otolaryngology, University of Colorado School of Medicine, Aurora, Colo.; and Division of Plastic Surgery, Departments of Surgery and Otolaryngology, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, Colo.
    Multiple, simultaneous skin cancers of the face are common. This is the first description of reconstructing discontinuous facial defects (i.e. Read More

    Association of ethnicity, Fitzpatrick skin type, and hirsutism: A retrospective cross-sectional study of women with polycystic ovarian syndrome.
    Int J Womens Dermatol 2017 Mar 13;3(1):37-43. Epub 2017 Mar 13.
    Department of Dermatology, University of California, San Francisco, CA.
    Background: The complex interplay between ethnicity, Fitzpatrick skin type (FST), and hirsutism in patients with polycystic ovarian syndrome (PCOS) is poorly understood.

    Objective: In this cross-sectional, retrospective analysis, we examined the prevalence, severity, and distribution of hirsutism with clinician-rated site-specific and total modified Ferriman-Gallwey (mFG) visual scoring in a diverse cohort of American patients with PCOS.

    Methods: Independent analyses were conducted on the basis of patient-reported FST ratings and ethnicity. Read More

    Endocrine evaluation of hirsutism.
    Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S6-S10. Epub 2017 Feb 16.
    University of Connecticut Medical Center, Department of Dermatology, Farmington, CT.
    Hirsutism is defined as excessive terminal hair growth in a male pattern in females. It typically affects 5 to 10% of reproductive-age women. Excessive hair growth can often cause significant psychological and emotional distress. Read More

    Prevalence of 'obesity-associated gonadal dysfunction' in severely obese men and women and its resolution after bariatric surgery: a systematic review and meta-analysis.
    Hum Reprod Update 2017 May 9:1-19. Epub 2017 May 9.
    Department of Endocrinology and Metabolism, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, E-28034 Madrid, Spain.
    Background: Sexual dimorphism manifests noticeably in obesity-associated gonadal dysfunction. In women, obesity is associated with androgen excess disorders, mostly the polycystic ovary syndrome (PCOS), whereas androgen deficiency is frequently present in obese men in what has been termed as male obesity-associated secondary hypogonadism (MOSH). Obesity-associated gonadal dysfunction, consisting of PCOS in women and MOSH in men, is a frequent finding in patients with severe obesity and it may be ameliorated or even resolve with marked weight loss, especially after bariatric surgery. Read More

    11-Oxygenated Androgens are Biomarkers of Adrenal Volume and Testicular Adrenal Rest Tumors in 21-Hydroxylase Deficiency.
    J Clin Endocrinol Metab 2017 May 1. Epub 2017 May 1.
    Division of Metabolism, Endocrinology and Diabetes (AFT, RJA), School of Public Health (AT), Department of Pharmacology (RJA), University of Michigan; National Institutes of Health (NIH) Clinical Center (AM, ME, JM, HR, DPM),National Heart Lung and Blood Institute (NAA), Eunice Kennedy Shriver National Institute of Child Health and Human Development (DPM), Bethesda, Maryland, 20892; Washington D.C. Veterans Affairs Medical Center, Radiology Service, Washington, DC (NAA).
    Context: Patients with 21-hydroxylase deficiency (21OHD) suffer from long-term complications, which might result from poor disease control and/or glucocorticoid overtreatment. Lack of optimal biomarkers has made it challenging to tailor therapy and to predict long-term outcomes.

    Objective: To identify biomarkers of disease control and long-term complications in 21OHD. Read More

    Use of cyproterone acetate/ethinylestradiol in polycystic ovary syndrome: rationale and practical aspects.
    Eur J Contracept Reprod Health Care 2017 Jun 2;22(3):183-190. Epub 2017 May 2.
    a Department of Gynecological Endocrinology , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.
    Introduction: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age.

    Objectives: To review the present knowledge about PCOS and summarize the role of CPA/EE in the care of patients suffering from this condition for the practitioner. Read More

    Paratubal Cyst Size Correlates With Obesity and Dysregulation of the Wnt Signaling Pathway.
    J Pediatr Adolesc Gynecol 2017 Apr 27. Epub 2017 Apr 27.
    Center for Reproductive Medicine, Baylor College of Medicine, Houston, Texas; Department of Urology, Baylor College of Medicine, Houston, Texas. Electronic address:
    Study Objective: Paratubal cysts (PTCs) occur in 7%-10% of women, regardless of age. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. The specific aims of the study were to determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from female adolescents. Read More

    Sexual function in infertile women with polycystic ovary syndrome and unexplained infertility.
    Am J Obstet Gynecol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Biostatistics, Yale University School of Public Health, New Haven, CT.
    Background: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed.

    Objective: The objective of the study was to determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility. Read More

    Congenital Adrenal Hyperplasia.
    J Pediatr Adolesc Gynecol 2017 Apr 24. Epub 2017 Apr 24.
    Division of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh. Electronic address:
    The congenital adrenal hyperplasias (CAH) comprise a family of autosomal recessive disorders that disrupt adrenal steroidogenesis. The most common form is due to21-hydroxylase deficiency associated with mutations in the CYP21A2 gene which is located at chromosome 6p21. The clinical features associated with each disorder of adrenal steroidogenesis represent a clinical spectrum reflecting the consequences of the specific mutations. Read More

    The use of cyproterone acetate/ethinyl estradiol in hyperandrogenic skin symptoms - a review.
    Eur J Contracept Reprod Health Care 2017 Jun 27;22(3):172-182. Epub 2017 Apr 27.
    c Departamento de Ginecologia e Obstetrícia da UFMG , Belo Horizonte , Brazil.
    Introduction: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Read More

    [Calcium and bone metabolism across women's life stages. Bone metabolism and estrogen/androgen balance in women.]
    Clin Calcium 2017;27(5):673-682
    Department of Reproductive and Menopausal Medicine, Tokushima University Graduate School, Japan.
    Androgen as well as estrogen has physical, psychological and sexual roles in women. The action of androgen on bone health in women is important. The androgen receptor is expressed in osteoblasts and osteocytes but the mechanism has not been clarified in women. Read More

    Effects of supervised aerobic training on the levels of anti-Mullerian hormone and adiposity measures in women with normo-ovulatory and polycystic ovary syndrome.
    J Pak Med Assoc 2017 Apr;67(4):499-507
    Rehabilitation Research Chair, College of Applied Medical Sciences, King Saud University, Riyadh, KSA.
    Objective: To evaluate the change in the levels of anti-Mullerian hormone, adiponectin, weight loss and fertility parameters in obese women with or without polycystic ovary syndrome, following 12 weeks of supervised aerobic exercise.

    Methods: This study was conducted from August 2013 to October 2014 among obese women with or without polycystic ovary syndrome referred to Obstetrics and Gynecology clinic, Mansoura University Hospital, Faculty of Medicine, Mansoura, Egypt. Patients were classified into three age-matched groups; group A had controls, group B had patients with polycystic ovary syndrome and group C had obese women. Read More

    A Case Report of Cushing's Disease Presenting as Hair Loss.
    Case Rep Dermatol 2017 Jan-Apr;9(1):45-50. Epub 2017 Feb 21.
    Department of Dermatology, Roger Williams Medical Center, Providence, RI, USA.
    Cushing's syndrome is a rare endocrine disorder that comprises a large group of signs and symptoms resulting from chronic exposure to excess corticosteroids. Most cases of Cushing's syndrome are due to increased adrenocorticotropic hormone production from a pituitary adenoma, which is referred to as Cushing's disease. Most of the signs and symptoms are nonspecific and common in the general population, making a diagnosis often challenging. Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Imatinib and spironolactone suppress hepcidin expression.
    Haematologica 2017 Apr 6. Epub 2017 Apr 6.
    Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany;
    Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis. Here, we investigated whether drugs targeting genetic regulators of hepcidin can affect iron homeostasis. We focused our efforts on drugs approved for clinical use to enable repositioning strategies and/or to reveal iron-related side effects of widely prescribed therapeutics. Read More

    Psychological distress, anger and quality of life in polycystic ovary syndrome: associations with biochemical, phenotypical andsocio-demographic factors.
    J Psychosom Obstet Gynaecol 2017 Apr 6:1-10. Epub 2017 Apr 6.
    b Reproductive Medicine Unit, San Paolo Hospital , University of Milan , Milan , Italy.
    Objective: To investigate the association between polycystic ovary syndrome (PCOS) and psychological disturbances, including anger. To analyze whether the biochemical/phenotypical features of PCOS play a role in the type and severity of psychological disorders.

    Material And Methods: This case-control study included 30 PCOS patients meeting NIH criteria and 30 non-PCOS women referring to Reproductive Medicine Unit for infertility. Read More

    Maternal hirsutism and autism spectrum disorders in offspring.
    Autism Res 2017 Apr 6. Epub 2017 Apr 6.
    Centre for Epidemiology and Community Medicine, Stockholm County Council, Stockholm, 17129, Sweden.
    Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD. Read More

    Flutamide-induced hepatotoxicity: ethical and scientific issues.
    Eur Rev Med Pharmacol Sci 2017 Mar;21(1 Suppl):69-77
    Section of Legal Medicine, Università Politecnica delle Marche, Ancona, Italy.
    Objective: Flutamide (FLU) is a non-steroidal antiandrogen drug approved for the treatment of advanced prostate cancer. While this indication limits the use to male patients, FLU is widely prescribed to women, off-label, for the treatment of polycystic ovary syndrome (POCS) related hirsutism and acne. According to the literature, its assumption is associated with a higher incidence of adverse events in women than in male patients. Read More

    Serum complexed and free prostate-specific antigen (PSA) for the diagnosis of the polycystic ovarian syndrome (PCOS).
    Clin Chem Lab Med 2017 Mar 31. Epub 2017 Mar 31.
    Department of Obstetrics and Gynecology, and Medicine, Medical College of Georgia, Augusta University, Augusta, GA.
    Background: Polycystic ovarian syndrome (PCOS) is a common cause of reproductive and metabolic dysfunction. We hypothesized that serum prostate-specific antigen (PSA) may constitute a new biomarker for hyperandrogenism in PCOS.

    Methods: We conducted a cross-sectional study of 45 women with PCOS and 40 controls. Read More

    Single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 genes in the pathogenesis of polycystic ovary syndrome.
    J Genet 2017 Mar;96(1):87-96
    Faculty of Biomedical Sciences, Sri Ramachandra University, Chennai 600 116, India.
    Polycystic ovary syndrome (PCOS) is the most common and a complex female endocrine disorder, and is one of the leading cause of female infertility. Here, we aimed to investigate the association of single-nucleotide polymorphism of INS, INSR, IRS1, IRS2, PPAR-G and CAPN10 gene in the pathogenesis of PCOS. A hospital-based, observational case-control study was carried on 169 PCOS and 169 control women in the southern region of India. Read More

    Intrafamilial Phenotypic Variability and Consequences of Non-Compliance with Treatment in Congenital Adrenal Hyperplasia and Congenital Hypothyroidism within a Single Family
    Horm Res Paediatr 2017 Mar 30. Epub 2017 Mar 30.
    Background: Coexistence of congenital adrenal hyperplasia (CAH) and congenital hypothyroidism (CH) due to TG mutation in the same non-consanguineous family is rare.

    Case Series: We report 4 siblings born to unrelated parents, the father being an asymptomatic carrier of homozygous p.V281L and heterozygous p. Read More

    Vitamin D Decreases Serum VEGF Correlating with Clinical Improvement in Vitamin D-Deficient Women with PCOS: A Randomized Placebo-Controlled Trial.
    Nutrients 2017 Mar 28;9(4). Epub 2017 Mar 28.
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.
    Vascular endothelial growth factor (VEGF) has been suggested to play a role in the pathophysiology of polycystic ovary syndrome (PCOS) and may contribute to increased risk of ovarian hyperstimulation syndrome (OHSS) in affected individuals. Vitamin D (VitD) supplementation improves multiple clinical parameters in VitD-deficient women with PCOS and decreases VEGF levels in several other pathologic conditions. Unveiling the basic mechanisms underlying the beneficial effects of vitamin D on PCOS may enhance our understanding of the pathophysiology of this syndrome. Read More

    Testosterone in Women: Measurement and Therapeutic Use.
    J Obstet Gynaecol Can 2017 Mar;39(3):124-130
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Queen's University, Kingston, ON.
    Androgens, both in excessive and depleted states, have been implicated in female reproductive health disorders. As such, serum testosterone measurements are frequently ordered by physicians in cases of sexual dysfunction and in women presenting with hirsutism. Commercially available androgen assays have significant limitations in the female population. Read More

    High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis.
    Hum Reprod 2017 May;32(5):1075-1091
    Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, 3701 Market Street Philadelphia, PA 19104, USA.
    Study Question: Do women with polycystic ovary syndrome (PCOS) have an increased prevalence of moderate and severe depressive and anxiety symptoms compared with control women, and do these symptoms correlate with age, BMI, testosterone, hirsutism or insulin resistance (IR)?

    Summary Answer: Women with PCOS have significantly increased odds of moderate and severe depressive and anxiety symptoms, independent of obesity, and the symptoms are weakly associated with age, BMI, elevated testosterone, hirsutism and IR.

    What Is Known Already: Previous studies have reported that women with PCOS have an increased prevalence of mild depressive and anxiety symptoms or an increase in mean depression and anxiety scores, although these scores are usually within the normal range. Thus, it is therefore not clear whether these findings are clinically significant. Read More

    Cushing's syndrome in infancy due to ectopic ACTH secretion by a sacro-coccygeal teratoma.
    J Pediatr Endocrinol Metab 2017 Apr;30(4):475-478
    Department of Pediatrics, Endocrinology and Diabetes with a Cardiology Unit, Medical University in Bialystok, ul. Waszyngtona 17, 15-274 Białystok.
    Background: Adenocorticotropic hormone (ACTH)-dependent Cushing's syndrome in infancy is extremely rare. We describe the case of a sacro-coccygeal ectopic ACTH-secreting immature teratoma in an infant who also presented the triad of defects characteristic of Currarino syndrome.

    Case Presentation: A girl was born with a large immature teratoma in the sacro-coccygeal region associated with anal atresia. Read More

    Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up.
    J Clin Endocrinol Metab 2017 Jun;102(6):1861-1869
    Department of Obstetrics and Gynecology, University Hospital of Oulu, University of Oulu, FI-90014 Oulu, Finland.
    Context: Polycystic ovary syndrome (PCOS) is associated with increased psychological distress, obesity and hyperandrogenism being suggested as key promoters.

    Objectives: To investigate the prevalence of anxiety/depression and their coexistence in women with PCOS/PCOS-related symptoms at ages 31 and 46. The roles of obesity, hyperandrogenism, and awareness of PCOS on psychological distress were also assessed. Read More

    Two Siblings with the Same Severe Form of 21-Hydroxylase Deficiency But Different Growth and Menstrual Cycle Patterns.
    Front Pediatr 2017 1;5:35. Epub 2017 Mar 1.
    Department of Endocrinology and Diabetology, University Children's Hospital, Zurich, Switzerland; Children's Research Centre, University Children's Hospital, Zurich, Switzerland.
    Congenital adrenal hyperplasia (CAH) is one of the most frequent autosomal recessive diseases in Europe. Treatment is a challenge for pediatric endocrinologists. Important parameters to judge the outcome are adult height and menstrual cycle. Read More

    Choosing the Right Oral Contraceptive Pill for Teens.
    Pediatr Clin North Am 2017 Apr;64(2):343-358
    Division of Adolescent Medicine, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. Electronic address:
    Oral contraceptive pills (OCPs) continue to be the most commonly used form of prescription contraceptives used by adolescents in the United States. With proper use, oral contraceptives provide safe and effective birth control. Broad categories of OCPs include progestin-only pills (POPs) and combined oral contraceptive pills (COCs). Read More

    Hyperleptinemia in children with autosomal recessive spinal muscular atrophy type I-III.
    PLoS One 2017 9;12(3):e0173144. Epub 2017 Mar 9.
    Department of Neuropediatrics, Developmental Neurology and Social Pediatrics, Children's Hospital 1, University of Duisburg-Essen, Essen, Germany.
    Background: Autosomal-recessive proximal spinal muscular atrophies (SMA) are disorders characterized by a ubiquitous deficiency of the survival of motor neuron protein that leads to a multisystemic disorder, which mostly affects alpha motor neurons. Disease progression is clinically associated with failure to thrive or weight loss, mainly caused by chewing and swallowing difficulties. Although pancreatic involvement has been described in animal models, systematic endocrinological evaluation of the energy metabolism in humans is lacking. Read More

    Hormonal therapies for acne.
    Clin Dermatol 2017 Mar - Apr;35(2):168-172. Epub 2016 Oct 27.
    Department of Dermatology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
    Acne is a common, worldwide problem that is usually multifactorial in etiology, but androgens may play a pivotal role in the development and severity of acne. Endocrinopathies, such as polycystic ovarian syndrome, ovarian tumors, or adrenal hyperplasia or tumors, may be detected in some patients with acne, especially if acne is sudden in onset, associated with hirsutism or menstrual irregularities, or associated with cushingoid facies, acanthosis nigricans, patterned hair loss, or deepened voice. In these instances, serum-free and total testosterone, dehydroepiandrosterone, luteinizing hormone, and follicle stimulating hormone should be tested. Read More

    High concentrations of LH cause virilization in a postmenopausal woman.
    Clin Case Rep 2017 Mar 27;5(3):225-228. Epub 2017 Jan 27.
    Division of Metabolism, Endocrinology and NutritionDepartment of MedicineUniversity of WashingtonSeattleWashingtonUSA; Division of General Internal MedicineDepartment of MedicineUniversity of WashingtonSeattleWashingtonUSA.
    Some testosterone-producing adrenal tumors can be successfully treated with long-acting GnRH analogs and adrenal venous sampling can be useful to detect rare ectopic sex steroid-producing tumors or confirm bilateral adrenal androgen hyperproduction in female hyperandrogenism. Read More

    A three-component cognitive behavioural lifestyle program for preconceptional weight-loss in women with polycystic ovary syndrome (PCOS): a protocol for a randomized controlled trial.
    Reprod Health 2017 Mar 6;14(1):34. Epub 2017 Mar 6.
    Division Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC, PO Box 2040, 3000, CA, Rotterdam, The Netherlands.
    Background: Obesity in women with polycystic ovary syndrome (PCOS) negatively affects all clinical features, and a 5 to 10% weight loss has shown promising results on reproductive, metabolic and psychological level. Incorporating a healthy diet, increasing physical activity and changing dysfunctional thought patterns in women with PCOS are key points in losing weight. The biggest challenge in weight management programs is to achieve a reasonable and sustainable weight loss. Read More

    Type B Insulin Resistance in Peru.
    Am J Med Sci 2017 Mar 30;353(3):258-262. Epub 2016 Aug 30.
    Endocrinology Unit, Hospital Nacional Arzobispo Loayza, Lima, Peru.
    Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a history of RA, SLE and Hashimoto-thyroiditis that presented with cachexia, acanthosis-nigricans, hirsutism, negative anti-insulin-ab and glucose level between 400 to 700 mg/dl, despite a total insulin dose of 1000 IU/day. She received pulses of cyclophosphamide along with prednisone. Read More

    Hyperandrogenemia and high prolactin in congenital utero-vaginal aplasia patients.
    Reproduction 2017 May 28;153(5):555-563. Epub 2017 Feb 28.
    Department of Gynecology and ObstetricsLaboratory of Molecular Medicine, University Hospital Erlangen, Erlangen, Germany
    Patients with the Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) have a congenital utero-vaginal cervical aplasia, but normal or hypoplastic adnexa and develop with normal female phenotype. Some reports mostly demonstrated regular steroid hormone levels in small MRKH cohorts including single MRKH patients with hyperandrogenemia and a clinical presentationof hirsutism and acne has also been shown. Genetically a correlation of WNT4 mutations with singular MRKH patients and hyperandrogenemia was noted. Read More

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