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Ophthalmic Genet 2019 Feb 15:1-6. Epub 2019 Feb 15.

a Sidney Kimmel Medical College , Thomas Jefferson University , Philadelphia , Pennsylvania , USA.

Background: Cornelia de Lange syndrome (CdLS) is a congenital disorder characterized by multisystem abnormalities, including distinct ophthalmologic findings. In recent years, advances in molecular genetics have begun to provide new insight into the characterization of these clinical features and the genetic basis of the syndrome.

Materials And Methods: We included 37 articles that were identified through an electronic search in PubMed and through the reference lists of previously conducted reviews. Read More

J Clin Endocrinol Metab 2019 Feb 8. Epub 2019 Feb 8.

Professor and Vice Chair of Medicine, Department of Medicine, University of Washington, Seattle, WA.

Context: The lifetime prevalence of anabolic androgenic steroid (AAS) use is estimated at 1-5% worldwide. AAS use occurs primarily male elite athletes and men who want a muscular appearance. The evidence for effective, safe management of AAS cessation and withdrawal is weak. Read More

Ugeskr Laeger 2019 Feb;181(6)

The diagnosis of an androgen-secreting tumour of the ovaries should be considered in women with hyperandrogenism. Clinical manifestations of hyperandrogenism include virilisation with hirsutism, vocal change, increased muscle mass, hypertrophy of clitoris and alopecia. Definitive diagnosis is made by histopathologic examination, and the most common diagnoses are granulosa cell tumour, ovarian stromal hyperplasia and Sertoli-Leydig cell tumour. Read More

Indian J Clin Biochem 2019 Jan 11;34(1):108-114. Epub 2017 Dec 11.

2Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Omentin-1 and prostate specific antigen (PSA) are known to be markers of insulin resistance and hyperandrogenism respectively in polycystic ovary syndrome (PCOS). This study aimed to assess the changes in serum omentin-1 and PSA levels in PCOS patients while on treatment. Serum omentin-1, PSA, BMI and Ferriman gallwey score (FG score) were measured in 80 women with PCOS. Read More

Case Rep Womens Health 2019 Jan 29;21:e00094. Epub 2018 Dec 29.

Research Committee, "Dr. Alberto Romo Caballero" School of Medicine, Universidad Autónoma de Tamaulipas, Tampico, Tamaulipas, Mexico.

We report a case of hyperreactio luteinalis (HL) and hypothyroidism diagnosed at 13 weeks of pregnancy. A 29-year-old woman with a spontaneous 13-week singleton pregnancy presented with hirsutism and a pelvic mass. Ultrasound showed a viable pregnancy compatible with the gestational age and multiple cystic lesions on both ovaries. Read More

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life. Read More

J Obstet Gynaecol Can 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics and Gynecology, College of Medicine, University of Saskatchewan, Saskatoon, SK. Electronic address:

Objective: This study compared the prevalence of metabolic syndrome (MetS) and characterized type 2 diabetes (DM2) and cardiovascular disease (CVD) risk profiles between Canadian women with polycystic ovary syndrome (PCOS) and healthy women recruited from the general population. Furthermore, within the PCOS cohort, the study contrasted the CVD and DM2 risk profiles of women with or without MetS.

Methods: Measures of MetS (International Diabetes Federation; National Heart, Lung, and Blood Institute; and the American Heart Association definition), DM2 (Diabetes Canada Clinical Guidelines), and CVD risk factors (Androgen Excess and Polycystic Ovary Syndrome Society statement) were evaluated for 237 women with PCOS (Androgen Excess and PCOS Society definitions) and 42 controls (aged 18-36) in a prospective observational study (Canadian Task Force classification II-2). Read More

J Gynecol Obstet Hum Reprod 2019 Jan 31. Epub 2019 Jan 31.

Adnan Menderes Boulevard (Vatan Road) Fatih, İstanbul, 34093, Turkey; Bezmialem Foundation University Medical Faculty, Department of Psychiatry, Turkey.

Aim: There is an unclear relationship between Polycystic Ovary Syndrome and psychiatric disorders including anxiety and depression. We aimed to evaluate temperamental and personal characteristics of patients with PCOS.

Methods: Fifty patients with PCOS and 41 healthy controls were included in the study. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 4;234:149-154. Epub 2019 Jan 4.

Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India.

Objectives: 1. To study the efficacy of exercise in improving clinical symptoms, anthropometry, glucose tolerance and laboratory profile in women with Polycystic ovarian syndrome. 2. Read More

J Pediatr Endocrinol Metab 2019 Feb;32(2):135-142

University of Verona, Verona, Italy.

Background To develop a diagnostic assessment tool, using clinical, biochemical and sonographic markers, to help clinicians in the differential diagnosis of functional oligomenorrhea (FO) and endocrine-metabolic oligomenorrhea (EMO). Methods Sixty-two adolescents with oligomenorrhea without evident hormonal imbalances or severe energy deficit were selected. They were divided into two groups (EMO and FO) and they all underwent the following assessment: physical examination (height, weight, presence of hirsutism or acne), blood exams and transabdominal ultrasonography. Read More

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

J Ovarian Res 2019 Jan 21;12(1). Epub 2019 Jan 21.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).

Methods: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 10 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Read More

Clin Endocrinol (Oxf) 2019 Jan 18. Epub 2019 Jan 18.

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Objective: Hirsutism affects 5%-10% of reproductive-aged women worldwide and exhibits clinical importance as a cutaneous manifestation of underlying hyperandrogenism. Racial and genetic factors play roles in manifestation of hirsutism, and the prevalence of hirsutism seems to be low in East Asians. However, the reference value of the modified Ferriman-Gallwey (mFG) score to diagnose hirsutism and the prevalence of hirsutism have not been determined in Korean populations to date. Read More

Am J Med Genet A 2019 Mar 17;179(3):486-493. Epub 2019 Jan 17.

Children's Rare Disease Institute, Washington, District of Columbia.

Mucopolysaccharidosis Type VII (MPS7, also called β-glucuronidase deficiency or Sly syndrome; MIM 253220) is an extremely rare autosomal recessive lysosomal storage disease, caused by mutations in the GUSB gene. β-glucuronidase (GUSB) is a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans (GAGs). Patients affected with MPS VII are not able to completely degrade glucuronic acid-containing GAGs, including chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate, and heparan sulfate. Read More

Gynecol Endocrinol 2019 Jan 16;35(1):1-3. Epub 2019 Jan 16.

d Department of Obstetrics and Gynecology Medical College of Georgia , Augusta University , Augusta , GA , USA.

The polycystic ovary syndrome (PCOS) is a common and important complex endocrine metabolic disorder affecting women mainly in the reproductive age. The prevalence of the disorder varies depending on the epidemiologic design and criterion used to study the disease. This variation in methodology and subsequent effect on epidemiologic estimate makes it difficult to compare prevalences and phenotypes across geographical areas and assess the effect of cultural and racial variations on PCOS phenotypes. Read More

Case Rep Endocrinol 2018 5;2018:8154513. Epub 2018 Dec 5.

Division Director, Department of Endocrinology, Berkshire Medical Center, Pittsfield, MA, USA.

Androgen-secreting ovarian neoplasms are rare ovarian tumors that present with hirsutism and virilization which may manifest as severe alopecia, deepening of voice, and clitoromegaly. Most often, ovarian tumors are found to be very small or even undetectable. In such cases, bilateral salpingo-oophorectomy should be performed after ruling out other causes of high androgens. Read More

Steroids 2019 Mar 6;143:62-66. Epub 2019 Jan 6.

Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège, Belgium.

Background: Androstanediol glucuronide is linked to a range of disorders of peripheral androgen formation and action, such as in hirsutism and acne. Nowadays its accurate quantification is still challenging and there are just a few LC-MS/MS methods available. Besides, their reference intervals for normal European populations by LC-MS/MS, including prepubertal and pubertal children, have not been reported yet. Read More

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

d Department of Internal Medicine (South), Faculty of Medicine , Universidad de Chile , Santiago , Chile.

Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. Read More

Postepy Dermatol Alergol 2018 Dec 13;35(6):631-635. Epub 2018 Nov 13.

Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo.

Introduction: Hirsutism is defined as excess terminal hair that commonly appears in a male pattern in women.

Aim: To examine severity and distribution of hirsutism with Ferriman-Gallwey visual scoring system in hirsute women in Kosovo.

Material And Methods: This prospective study included 160 women, 135 with hirsutism and 25 as a control group. Read More

Clin Exp Dermatol 2019 Jan 6. Epub 2019 Jan 6.

Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.

Rubinstein-Taybi syndrome (RSTS) is a rare congenital disorder, mainly characterized by postnatal growth retardation, intellectual disability, and facial and limb abnormalities. Although not considered as characteristic manifestations, numerous cutaneous anomalies have also been reported in patients with RSTS while there has been no report of desquamation so far in any patients with RSTS. We report an unusual case of RSTS in an 8-year-old boy who presented with the typical facial and limb abnormalities of RSTS accompanied with apparent hirsutism and desquamation, but without apparent intellectual disability. Read More

Hum Reprod Update 2019 Jan 4. Epub 2019 Jan 4.

Women's Health Research Unit, The Blizard Institute, Queen Mary University of London, London, UK.

Background: Polycystic ovary syndrome (PCOS) is a major contributor to subfertility, diabetes and cardiovascular disease in women. The role of non-pharmacological interventions to prevent these outcomes has been reported in many systematic reviews, but robust conclusions have not been made due to variations in the scope, quality and findings of these reviews.

Objective And Rationale: Our aim was to provide an overview of existing evidence on the effects of non-pharmacological interventions in women with PCOS on fertility and non-fertility outcomes by a review of existing systematic reviews. Read More

Int J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Department of Dermatology, University of California, Irvine, Irvine, CA, USA.

Background: Physicians are beginning to use finasteride as treatment for hair loss, hirsutism, and various other dermatologic conditions in women. However, the reported efficacy and use of finasteride in the female population varies widely. The purpose of this study is therefore to better define the efficacy and use of finasteride in women and identify research gaps that require further investigation. Read More

Am Fam Physician 2019 Jan;99(1):55

University of Georgia, Athens, GA, USA.

Clin Diabetes Endocrinol 2018 18;4:23. Epub 2018 Dec 18.

3PeaceHealth Southwest Medical Center Diabetes Endocrine & Nutrition, 400 NE Mother Joseph Place, Vancouver, WA 98664 USA.

Background: Cortisol resistance syndrome is a very rare condition characterized by high cortisol levels, but without any clinical features of Cushing's syndrome. Our objective is to present such a case.

Case Presentation: A 41 year old female presented with mild hirsutism and elevated urinary cortisol levels. Read More

Int J Endocrinol Metab 2018 Oct 20;16(4 Suppl):e84786. Epub 2018 Oct 20.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.

Context: Reproductive domains of the Tehran lipid and glucose study (TLGS) are unique in that they provide reliable information on reproduction of an urban population of West Asia. The aim of this review is to present the most important reproductive findings of TLGS.

Evidence Acquisition: This review is summarizing all articles published in the context of reproductive aspects of TLGS results over the 20-year follow-up. Read More

Ann Med Surg (Lond) 2019 Jan 29;37:21-24. Epub 2018 Nov 29.

Iran University of Medical Science, Tehran, Iran.

Introduction: Primitive neuroectodermal tumors (PNET) form a group of tumors defined by their appearance that are thought to develop from primitive (undifferentiated) nerve cells in the brain. They are rare tumors and their incidence is not well defined.

Case Presentation: An 18-month-old male presenting with typical Cushingoid appearance (moon face, central obesity, hirsutism and growth arrest) was admitted for evaluation of endocrine problems. Read More

Int J Womens Health 2018 28;10:763-771. Epub 2018 Nov 28.

Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khoudh, Sultanate of Oman.

Purpose: Literature emerging from Western countries has reported increased levels of serum oxidative stress markers among polycystic ovarian syndrome (PCOS) women. In the Arab region, there is limited research about the association between oxidative stress and PCOS. This study aimed to compare sociodemographic and clinical characteristics, sex hormones, and oxidative stress indices between PCOS women and non-PCOS women and to investigate the correlation between oxidative stress biomarkers and sex hormones. Read More

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

H Falhammar, Depatment of Endocrinology, Metabolism and Diabetes, Karolinska Universitetssjukhuset, Stockholm, 171 76, Sweden.

Non-classic congenital adrenal hyperplasia (NCAH) is a relatively common disorder regardless of ethnicity, but most cases are never diagnosed, especially in males. A baseline 17-hydroxyprogesterone measurement may be used for screening, but 17-hydroxyprogesterone measurement after ACTH-stimulation is the gold standard. We advocate a CYP21A2 mutation analysis to verify the diagnosis, for genetic counselling and for better prognostic and treatment guidance. Read More

Biol Trace Elem Res 2018 Dec 18. Epub 2018 Dec 18.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Synergistic approach of magnesium and vitamin E may benefit clinical symptoms of patients with polycystic ovary syndrome (PCOS) through improving their metabolic profiles and reducing oxidative stress and inflammation. This study was designed to determine the effects of magnesium and vitamin E co-supplementation on hormonal status and biomarkers of inflammation and oxidative stress in women with PCOS. This randomized, double-blind, placebo-controlled trial was conducted among 60 women with PCOS, aged 18-40 years old. Read More

Fertil Steril 2019 Feb 7;111(2):381-388. Epub 2018 Dec 7.

Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.

Objective: To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche.

Design: Case-control study.

Setting: Clinical endocrinology unit. Read More

Fertil Steril 2019 Feb 7;111(2):389-396. Epub 2018 Dec 7.

Department of Obstetrics and Gynecology, University of California, Los Angeles, California; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation; Department of Health Policy, Management, and Behavior, School of Public Health, State University of New York, Albany, New York. Electronic address:

Objective: To test the hypothesis that the polycystic ovary syndrome (PCOS) phenotype, or its component features, is less severe in adolescents than in young adult patients, in a referred (clinical) population.

Design: Cross-sectional study.

Setting: Tertiary-care academic medical center. Read More

Singapore Med J 2018 Nov;59(11):567-571

Department of Endocrinology, Changi General Hospital, Singapore.

Polycystic ovary syndrome (PCOS) presents with a spectrum of conditions resulting from androgen excess, anovulation and metabolic syndrome. Patients with PCOS may see their primary care physicians for various presentations, including hirsutism, acne, menstrual irregularities, infertility, obesity, and psychiatric disorders such as anxiety and depression. Management of these patients should include screening for Type 2 diabetes mellitus, dyslipidaemia and hypertension. Read More

Mali Med 2018 ;33(1):35-37

Service de médecine interne et d'endocrinologie de l'hôpital du Mali.

The authors are reporting here for the first time a documented case of androgen-secreting luteal cyst responsible for primary sterility in Mali. A 26-year married woman with a history of familial hyper androgenia of diabetes and high blood pressure who consulted for hyper androgen syndrome and primary infertility. Hirsutism with the presence of hairs on her chin, upper lips, thorax, forearms, arms, and her legs under waxing which made a Ferriman and Galloway scoreof10. Read More

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Endocrinology, South Tipperary General Hospital, Clonmel, Ireland.

Postmenopausal hyperandrogenism is a relatively rare diagnosis resulting from excess androgen production from the adrenals or ovaries. The exclusion of malignant causes is a priority. Laboratory tests and imaging are utilised to help differentiate the source of excess androgens. Read More

Breast Cancer Res Treat 2018 Nov 22. Epub 2018 Nov 22.

Department of Dermatology, Memorial Sloan-Kettering Cancer Center, 16 East 60th Street, Suite 407, 4th Floor, New York, NY, 10022, USA.

Purpose: To provide dermatologists and oncologists with a foundation for practical understanding and uses of 5α-reductase inhibitors and spironolactone for breast cancer patients and survivors receiving endocrine therapies (ETs), including the effect of these treatments on sex hormone levels, any reported drug interactions, and any risk of malignancy.

Methods: All published studies from January 1978 through April 2018 were considered, using databases such as PubMed, Google Scholar, and Science Direct. Forty-seven studies were included in this review. Read More

J Ayub Med Coll Abbottabad 2018 Jul-Sep;30(3):458-462

Department of Obstetrics and Gynaecology, Foundation University Medical College /Fauji Foundation Hospital Rawalpindi, Pakistan.

Non-classic congenital adrenal hyperplasia is a genetic condition caused by deficiency of 21- hydroxylase deficiency (NCAH). It is a milder and later onset form of a genetic condition known as congenital adrenal hyperplasia. We present four cases of non-classical congenital adrenal hyperplasia presented in gynae OPD foundation university medical college Fauji foundation hospital from Jan 2016 to March 2017. Read More

Int J Environ Res Public Health 2018 11 20;15(11). Epub 2018 Nov 20.

Department of Human Nutrition and Foods, West Virginia University, Morgantown, WV 26506, USA.

Polycystic ovarian syndrome (PCOS) is thought to be the most common endocrine disorder found in women. Common symptoms include irregular menstrual cycle, polycystic ovaries, and hirsutism, as well as an increased risk for a multitude of conditions, including insulin resistance, dyslipidemia and infertility. The prevalence of polycystic ovarian syndrome is generally thought to be between 3% and 10% but it is widely unknown for specific subpopulations based on geographical location and race/ethnicity. Read More

J Clin Endocrinol Metab 2018 Nov 15. Epub 2018 Nov 15.

Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland.

Context: PCOS is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension.

Objective: To investigate in a population-based set-up whether PCOS associates with the risk of hypertension independently of body-mass-index (BMI), and with cardiovascular manifestations.

Design: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46. Read More

J Obstet Gynaecol 2018 Nov 14:1-6. Epub 2018 Nov 14.

d Institute of Endocrinology , Prague , Czech Republic.

Leydig cell tumours of the ovary are rare and represent a diagnostic challenge not only due to their sporadic incidence but also due to the seemingly normal imaging. We present three cases of pre- and postmenopausal women who were presented with severe clinical signs of hyperandogenism where modern imaging modalities (including computed tomography (CT), magnetic resonance imaging (MRI) and positron-emission tomography combined with computed tomography (PET-CT)) failed to identify the tumour. Two patients underwent non-expert ultrasound, CT and MRI examination with uniform conclusion that ovaries are of normal appearance. Read More

Cureus 2018 Aug 25;10(8):e3203. Epub 2018 Aug 25.

Department of Community Health Sciences, Jinnah Medical and Dental College, Karachi, PAK.

Background Metformin is a highly preferred drug that is used to treat the symptoms of polycystic ovarian syndrome among women. Pakistan is facing a continuous rise in the prevalence of polycystic ovarian syndrome. Therefore, the determination of the effectiveness of the drug in this condition is considered ideal as per the presenting situation. Read More

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

N Shah, Mumbai, 400012, India.

Aims: Literature on virilising ovarian tumors (VOT) is limited to case reports and series reporting single pathological type. We have analyzed the clinical, hormonal, radiological, histological, management and outcome data of VOT.

Materials And Methods: This retrospective study was conducted at a tertiary health care center from Western India. Read More

Reprod Med Biol 2018 Oct 21;17(4):504-508. Epub 2018 Jun 21.

Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine Sapporo Japan.

Case: A 32 year old woman was referred because of secondary amenorrhea, hirsutism, and voice deepening.

Outcome: The blood testosterone level was markedly high. A transvaginal ultrasound revealed a small region in the left ovary, but whether or not it was a tumor was unclear. Read More

Reprod Biol Endocrinol 2018 Oct 30;16(1):107. Epub 2018 Oct 30.

Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU Lille, 2 Avenue Eugène Avinée, 59037, Lille, France.

Background: Maternal virilization during pregnancy is a rare phenomenon. Polycystic ovary syndrome (PCOS), luteoma and luteinic cysts are the most frequent and benign etiologies. This article presents two cases of recurrent maternal virilization during pregnancy. Read More

Endocrinology 2018 Dec;159(12):4056-4064

Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil.

The main clinical feature associated with hyperandrogenism in polycystic ovary syndrome (PCOS) in humans is hirsutism, where hair increases its length, pigmentation, and particularly its diameter. Currently, it is not known whether PCOS animal models also exhibit changes in the hair. Therefore, the aim of this study was to explore the wool characteristics in sheep prenatally androgenized (PA) with testosterone propionate. Read More

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

J Clin Med 2018 Oct 28;7(11). Epub 2018 Oct 28.

Department of Human Nutrition and Foods, West Virginia University, Morgantown, WV 26506, USA.

Polycystic Ovarian Syndrome (PCOS), with common symptoms of irregular menstrual cycles, ovarian cysts, and hirsutism, is thought to be the most common endocrine disorder found in women, and use of multidisciplinary teams has been shown to be effective. The purpose of this review is to determine the future need for specialized, comprehensive, multidisciplinary treatment for PCOS and the current description and efficacy of existing multidisciplinary clinics. The literature was searched using PubMed, CINAHL, PsycINFO, Medline, and the Cochrane Library. Read More

Curr Drug Discov Technol 2018 Oct 29. Epub 2018 Oct 29.

Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: The aim of this study was to evaluate the efficacy of the herbal tea based on Foeniculum vulgare, on inducing regular bleeding in women with oligomenorrhea and secondary amenorrhea(oligo/amenorrhea).

Methods: Forty women aged 18- 40 with oligo/amenorrhea were enrolled in this randomized controlled clinical trial and were allocated to two groups equally. The women in the first group were treated by Fomentex (Foeniculum vulgare / Mentha longifolia / Vitex agnus-castus) herbal tea 11. Read More

Acta Med Indones 2018 Jul;50(3):257-259

Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia.

Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1. Read More

Pediatr Dermatol 2018 Nov 15;35(6):808-816. Epub 2018 Oct 15.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Background: Recent reports indicate that tufted angioma is a rare vascular neoplasm that manifests more frequently at birth than previously thought. Few studies specifically address congenital presentation.

Objectives: We analyzed the clinicopathological characteristics, clinical course, and treatment of congenital tufted angioma (cTA) and evaluated variables that were indicative of problematic lesions. Read More