6,272 results match your criteria Hirsutism


Effect of metformin on clinical and biochemical hyperandrogenism in adolescent girls with type 1 diabetes.

J Pediatr Endocrinol Metab 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatric Endocrinology, DEMPU, Cairo University, Cairo, Egypt.

Background Hyperandrogenism with or without polycystic ovarian syndrome is seen in adolescents with type 1 diabetes (T1D), especially those with suboptimal control. Objective To assess the effect of metformin on hyperandrogenism and ovarian function in adolescents with T1D. Methods This prospective study included 28 T1D females showing signs of hyperandrogenism. Read More

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http://dx.doi.org/10.1515/jpem-2018-0430DOI Listing

The effect of atorvastatin on cardiometabolic risk factors in women with non-classic congenital adrenal hyperplasia: A pilot study.

Pharmacol Rep 2019 Jan 31;71(3):417-421. Epub 2019 Jan 31.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Background: Individuals with non-classic congenital adrenal hyperplasia (NC-CAH) often show evidence of hyperandrogenism, including premature pubarche, accelerated linear growth velocity, short final height, hirsutism, acne, alopecia, impaired ovulation, menstrual dysfunction and subfertility. Although statins were found to reduce elevated levels of androgens in subjects with this disorder, no previous study has investigated whether 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors affect cardiometabolic risk factors in patients with NC-CAH.

Methods: We studied 12 women with NC-CAH, 6 of whom because of coexisting hypercholesterolemia received atorvastatin (20-40 mg daily). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17341140183066
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http://dx.doi.org/10.1016/j.pharep.2019.01.014DOI Listing
January 2019
1 Read

A Clinical Evidence of a Correlation Between Insulin Resistance and the ALCAT Food Intolerance Test.

Altern Ther Health Med 2019 Mar;25(2):22-38

Insulin resistance (IR) is defined as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization. Several mechanisms have been proposed as possible causes underlying the development of IR and the IR syndrome. IR occurs as part of a cluster of cardiovascular-metabolic abnormalities commonly referred to as "The Metabolic Syndrome. Read More

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March 2019
2 Reads

The clinical features and reproductive prognosis of ovarian neoplasms with hyperandrogenemia: a retrospective analysis of 33 cases.

Gynecol Endocrinol 2019 Apr 16:1-4. Epub 2019 Apr 16.

a Peking Union Medical College Hospital , Dongcheng-qu , China.

The aim of this study is to review the natural course, clinical features, and reproductive prognosis of ovarian tumors associated with hyperandrogenemia. We retrospect 33 patients of ovarian tumors with hyperandrogenemia. Thirty cases (91%) were sex cord-stromal tumors. Read More

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http://dx.doi.org/10.1080/09513590.2019.1599855DOI Listing
April 2019
1 Read

Depression over the lifespan in a population-based cohort of women with polycystic ovary syndrome: longitudinal analysis.

J Clin Endocrinol Metab 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, CA.

Purpose: To 1) determine whether women with polycystic ovary syndrome (PCOS) from a population-based cohort experience elevated depression symptoms, and 2) characterize the trajectory of symptoms over the lifespan.

Methods: The association between PCOS and longitudinal depression scores was investigated among 1,127 black and white women participating in Coronary Artery Risk Development in Young Adults (CARDIA) study. PCOS was ascertained at baseline (ages 20-32) by NIH criteria, incorporating androgens and symptoms of oligomenorrhea and hirsutism. Read More

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http://dx.doi.org/10.1210/jc.2019-00234DOI Listing
April 2019
1 Read

Dietary Protein Deficit and Deregulated Autophagy: A New Clinico-diagnostic Perspective in Pathogenesis of Early Aging, Skin, and Hair Disorders.

Indian Dermatol Online J 2019 Mar-Apr;10(2):115-124

Department of Dermatology, Aesthetic Surgery and Intervention Dermatology, AURA Skin Institute, Chandigarh, India.

Background: Diet has an important role to play in the well-being of human body.

Aims: The study intends to establish the "hypothesis of conscious, selective, and self-destruction i.e. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_123_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434747PMC
April 2019
4 Reads

Update on Management of Polycystic Ovarian Syndrome for Dermatologists.

Indian Dermatol Online J 2019 Mar-Apr;10(2):97-105

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_249_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434760PMC

Aromatase Deficiency in Two Siblings with 46, XX KaryotypeRraised as Different Genders: A Novel Mutation (p.R115X) in Gene

J Clin Res Pediatr Endocrinol 2019 Apr 10. Epub 2019 Apr 10.

Department of Pediatric Endocrinology, School of Medicine, Ege University, Izmir, Turkey

Aromatase deficiency rarely causes a 46, XX sexual differentiation disorder. The gene encodes the aromatase enzyme which catalyses the conversion of androgens to oestrogens. In cases with 46, XX karyotype, mutations in the gene can lead to disorders of sex development. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2018.0198DOI Listing
April 2019
2 Reads

Confluent and Reticulated Papillomatosis Associated with Polycystic Ovarian Syndrome.

Cureus 2019 Jan 25;11(1):e3956. Epub 2019 Jan 25.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Polycystic ovarian syndrome is an endocrine disorder diagnosed commonly in young women. Various cutaneous manifestations can include acanthosis nigricans, acne, hirsutism, and alopecia. Confluent and reticulated papillomatosis is a rare skin condition that may be associated with polycystic ovarian syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436673PMC
January 2019
1 Read

ACTH-producing adenoma of the pituitary gland manifesting as severe insulin resistance.

J Surg Case Rep 2019 Mar 29;2019(3):rjz070. Epub 2019 Mar 29.

Campbell University, School of Osteopathic Medicine, Novant Health Presbyterian, Internal Medicine, Charlotte, NC, USA.

Pituitary adenomas are commonly benign neoplasms which may manifest with a wide variety of symptomatology. Typically, ACTH- producing tumors of the pituitary gland present with central fat deposition, abdominal striae, moon facies, buffalo hump, osteoporosis, hypertension, hirsutism, gonadal dysfunction, immunosuppression, and less commonly with hyperglycemia due to insulin resistance. We report the case of a 58-year-old male patient with an ACTH producing pituitary microadenoma and type 2 Diabetes Mellitus (DM) whose primary presenting symptom was increasing insulin resistance despite appropriate adjustments to his insulin therapy. Read More

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https://academic.oup.com/jscr/article/doi/10.1093/jscr/rjz07
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http://dx.doi.org/10.1093/jscr/rjz070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439515PMC
March 2019
5 Reads

Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach.

J Diabetes Metab Disord 2018 Dec 13;17(2):277-285. Epub 2018 Nov 13.

3Department of Endocrinology, Diabetes & Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Lincoln, PE21 9QS UK.

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. Common features include menstrual irregularities, hyperandrogenism and polycystic ovarian morphology although the presentation can be heterogeneous. Insulin resistance is thought to be responsible for the hormonal and metabolic derangements observed. Read More

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http://dx.doi.org/10.1007/s40200-018-0371-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405408PMC
December 2018
2 Reads

Cushing syndrome: uncovering Carney complex due to novel PRKAR1A mutation.

Endocrinol Diabetes Metab Case Rep 2019 Mar 21;2019. Epub 2019 Mar 21.

Departments of Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Carney complex (CNC) is a rare multiple neoplasia syndrome characterized by spotty pigmentation of the skin and mucosa in association with various non-endocrine and endocrine tumors, including primary pigmented nodular adrenocortical disease (PPNAD). A 20-year-old woman was referred for suspected Cushing syndrome. She had signs of cortisol excess as well as skin lentigines on physical examination. Read More

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http://dx.doi.org/10.1530/EDM-18-0150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432981PMC
March 2019
2 Reads

Photobiomodulation can improve ovarian activity in polycystic ovary syndrome-induced rats.

J Photochem Photobiol B 2019 Mar 12;194:6-13. Epub 2019 Mar 12.

Medicinal Chemistry and Regenerative Medicine Group, QUIMMERA - UNIARA, Araraquara, SP, Brazil; Department of Biological Science and Health - Medicine, University of Araraquara - UNIARA, Araraquara, SP, Brazil. Electronic address:

Follicular cystic ovary disease is a common reproductive disorder in women and females of domestic animals, characterized by anovulation and the persistence of follicle is a common cause of reproductive failure in mammalian. Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism (HA), chronic anovulation and polycystic ovaries, and it is a common reproductive endocrine disease with clinical manifestations including hirsutism, acne, infertility and obesity that can affect 5-20% of women in their reproductive age. Photobiomodulation (PBM) has been investigated and used in clinical practice, related to biomodulatory influences on cellular functions in animals and humans, both in vivo and in vitro. Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.006DOI Listing
March 2019
3 Reads

Clinical Diagnosis of Classical Cornelia de Lange Syndrome Made From Postmortem Examination of Second Trimester Fetus With Novel NIPBL Pathogenic Variant.

Pediatr Dev Pathol 2019 Mar 19:1093526619834429. Epub 2019 Mar 19.

1 Department of Clinical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Classical Cornelia de Lange syndrome (CdLS) is a rare genetic disorder which is associated with distinctive facial features, growth retardation, significant intellectual disability and global developmental delay, hirsutism, and upper-limb reduction defects. Classical CdLS is associated with pathogenic variants in NIPBL. We present a clinical diagnosis of classical CdLS made in a second trimester male fetus with advanced maceration who had undergone intrauterine death at 15 + 6 weeks gestation. Read More

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http://dx.doi.org/10.1177/1093526619834429DOI Listing
March 2019
2 Reads

Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting.

Pharm Dev Technol 2019 Mar 19:1-37. Epub 2019 Mar 19.

a Department of Pharmaceutics, Faculty of Pharmacy , Shiraz University of Medical Sciences , Shiraz , Iran.

Cyproterone acetate (CPA) is used to treat various skin disorders such as acne, hirsutism and alopecia. Due to the limited skin penetration of CPA, nanostructured lipid carriers (NLCs) with different size ranges were considered in this study in order to enhance skin penetration and to target hair follicles. Drug loading, drug release and morphological assessment were evaluated for each targeted size (100, 300 and 600 nm). Read More

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http://dx.doi.org/10.1080/10837450.2019.1596133DOI Listing
March 2019
18 Reads
1.335 Impact Factor

Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS.

F1000Res 2019 23;8:94. Epub 2019 Jan 23.

Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.

Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Read More

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http://dx.doi.org/10.12688/f1000research.16815.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406175PMC
January 2019
2 Reads

Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50): a psychometric study with the Serbian version.

Women Health 2019 Mar 14:1-11. Epub 2019 Mar 14.

b Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine , University of Belgrade , Belgrade , Serbia.

This study aimed to analyze the measurement properties of the Health-related quality of life questionnaire for polycystic ovary syndrome (PCOSQ-50) in a sample of Serbian women with polycystic ovary syndrome (PCOS). Seventy-six women with PCOS from an endocrinology clinic and 28 healthy women participated between October 2016 and March 2017. The measure was rigorously translated and culturally adapted into Serbian. Read More

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http://dx.doi.org/10.1080/03630242.2019.1587664DOI Listing
March 2019
2 Reads

How to Evaluate Acne in Reproductive-Age Women: An Epidemiological Study in Chinese Communities.

Biomed Res Int 2019 3;2019:6126808. Epub 2019 Feb 3.

Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China.

Background: Acne is not only a skin condition but also a cardinal component of many systemic diseases or syndromes. This study was aimed to investigate the prevalence of acne in reproductive-age women in Sichuan province, China, and to evaluate acne as a skin problem alone or a symptom of gynecological/endocrinological disease.

Methods: From October 2008 to September 2009, 1043 reproductive-age women from 19 to 45 years of age from seven communities of three districts in Sichuan province completed a standardized questionnaire and a physical examination. Read More

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http://dx.doi.org/10.1155/2019/6126808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378077PMC
February 2019
2 Reads

Carnitine and chromium co-supplementation affects mental health, hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome.

J Psychosom Obstet Gynaecol 2019 Mar 5:1-9. Epub 2019 Mar 5.

c Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.

Objective: The aim of this study was to evaluate the effect of the co-administration of carnitine and chromium on mental health, hormonal, inflammatory and genetic parameters in women with PCOS.

Methods: This randomized, double-blinded, placebo-controlled clinical trial was conducted on 54 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 1000 mg/d carnitine plus 200 µg/d chromium as chromium picolinate (n = 26) or placebo (n = 27) for 12 weeks. Read More

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http://dx.doi.org/10.1080/0167482X.2018.1557144DOI Listing
March 2019
6 Reads

Methods of treatment patients with androgenetic alopecia based on reference of Department of Dermatology in Cracow.

Pol Merkur Lekarski 2019 Feb;46(272):80-83

Department of Dermatology, Jagiellonian University, Collegium Medicum, Cracow, Poland.

Androgenetic alopecia (AGA in men/female pattern hair loss FPHL in women) has been associated with the most frequent culprit of hair loss concerning both men and women. It may be viewed as chronic, progressive, non scarring type of hair loss. The main factor in its pathophysiological mechanism plays genetic susceptibility to androgens of certain individuals. Read More

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February 2019
5 Reads

Polycystic ovarian syndrome: Environmental/occupational, life style factors-an overview

J Turk Ger Gynecol Assoc 2019 Mar 1. Epub 2019 Mar 1.

Former, Scientist G & Director-in-Charge NIOH (ICMR), Ahmedabad, India

PCOS is a multifaceted disease in women with infertility that have diverse etiological factors. Some women may have only a few PCOS linked symptoms or mild symptoms while some of the women will have severe or all PCOS linked symptoms. Therefore, the PCOS symptoms can differ among the woman. Read More

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http://dx.doi.org/10.4274/jtgga.galenos.2019.2018.0142DOI Listing
March 2019
3 Reads

[Phenotype and genotype of twelve Chinese children with mitochondrial DNA depletion syndromes].

Zhonghua Er Ke Za Zhi 2019 Mar;57(3):211-216

Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To explore the phenotype and genotype of mitochondrial DNA depletion syndromes (MDS) in Chinese children. The clinical and genetic data of 12 MDS patients (8 were boys and 4 were girls) diagnosed in the Department of Neurology in Beijing Children's Hospital, Capital Medical University from October 2010 to April 2018 were retrospectively collected and analyzed. The developmental milestones were normal or mildly retardated before disease onset. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2019.03.011DOI Listing
March 2019
10 Reads

Comprehensive genotyping of Turkish women with hirsutism.

J Endocrinol Invest 2019 Feb 27. Epub 2019 Feb 27.

Department of Endocrinology, Medical Faculty, Erciyes University, Kayseri, Turkey.

Introduction: Hirsutism is a medical sign rather than a disease affects 5-8% of women of reproductive age. Hirsutism is associated with hyperandrogenemia in most patients excluding those with idiopathic hirsutism (IH). The most common cause of hirsutism is polycystic ovary syndrome (PCOS) followed by IH and idiopathic hyperandrogenemia (IHA); however, the clinical presentation of non-classical congenital adrenal hyperplasia (NCAH) in females is often indistinguishable from other hyperandrogenic disorders with common clinical signs such as hirsutism. Read More

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http://dx.doi.org/10.1007/s40618-019-01028-3DOI Listing
February 2019
2 Reads

Cardiovascular profile of pharmacological agents used for the management of polycystic ovary syndrome.

Ther Adv Endocrinol Metab 2019 6;10:2042018818805674. Epub 2018 Nov 6.

Weill Cornell Medicine Qatar, Research Department, PO Box 24144, Doha, Qatar.

Women with polycystic ovary syndrome (PCOS) have an adverse metabolic profile with an increased risk of prediabetes and type 2 diabetes (T2DM); however, it is unclear if PCOS is associated with increased cardiovascular events in later years independent of the presence of T2DM. Many therapies have been used to treat the differing facets of PCOS, including those for menstrual irregularity, hirsutism, acne and anovulatory infertility. The aim of this review was to evaluate the cardiovascular profiles associated with the medications used in the management of PCOS and evaluate whether they have cardiovascular benefit, detriment or are neutral. Read More

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http://dx.doi.org/10.1177/2042018818805674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378434PMC
November 2018
3 Reads

Ophthalmologic findings in the Cornelia de Lange syndrome.

Ophthalmic Genet 2019 Feb 15;40(1):1-6. Epub 2019 Feb 15.

a Sidney Kimmel Medical College , Thomas Jefferson University , Philadelphia , Pennsylvania , USA.

Background: Cornelia de Lange syndrome (CdLS) is a congenital disorder characterized by multisystem abnormalities, including distinct ophthalmologic findings. In recent years, advances in molecular genetics have begun to provide new insight into the characterization of these clinical features and the genetic basis of the syndrome.

Materials And Methods: We included 37 articles that were identified through an electronic search in PubMed and through the reference lists of previously conducted reviews. Read More

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https://www.tandfonline.com/doi/full/10.1080/13816810.2019.1
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http://dx.doi.org/10.1080/13816810.2019.1571617DOI Listing
February 2019
16 Reads

Diagnosis and management of anabolic androgenic steroid use.

J Clin Endocrinol Metab 2019 Feb 8. Epub 2019 Feb 8.

Professor and Vice Chair of Medicine, Department of Medicine, University of Washington, Seattle, WA.

Context: The lifetime prevalence of anabolic androgenic steroid (AAS) use is estimated at 1-5% worldwide. AAS use occurs primarily male elite athletes and men who want a muscular appearance. The evidence for effective, safe management of AAS cessation and withdrawal is weak. Read More

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http://dx.doi.org/10.1210/jc.2018-01882DOI Listing
February 2019
2 Reads

[Androgen-secreting tumours of the ovaries].

Ugeskr Laeger 2019 Feb;181(6)

The diagnosis of an androgen-secreting tumour of the ovaries should be considered in women with hyperandrogenism. Clinical manifestations of hyperandrogenism include virilisation with hirsutism, vocal change, increased muscle mass, hypertrophy of clitoris and alopecia. Definitive diagnosis is made by histopathologic examination, and the most common diagnoses are granulosa cell tumour, ovarian stromal hyperplasia and Sertoli-Leydig cell tumour. Read More

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February 2019
3 Reads

A Study on Omentin-1 and Prostate Specific Antigen in Women on Treatment for Polycystic Ovary Syndrome.

Indian J Clin Biochem 2019 Jan 11;34(1):108-114. Epub 2017 Dec 11.

2Department of Obstetrics and Gynecology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Omentin-1 and prostate specific antigen (PSA) are known to be markers of insulin resistance and hyperandrogenism respectively in polycystic ovary syndrome (PCOS). This study aimed to assess the changes in serum omentin-1 and PSA levels in PCOS patients while on treatment. Serum omentin-1, PSA, BMI and Ferriman gallwey score (FG score) were measured in 80 women with PCOS. Read More

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http://dx.doi.org/10.1007/s12291-017-0723-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346616PMC
January 2019
3 Reads

Hyperreactio luteinalis and hypothyroidism: A case report.

Case Rep Womens Health 2019 Jan 29;21:e00094. Epub 2018 Dec 29.

Research Committee, "Dr. Alberto Romo Caballero" School of Medicine, Universidad Autónoma de Tamaulipas, Tampico, Tamaulipas, Mexico.

We report a case of hyperreactio luteinalis (HL) and hypothyroidism diagnosed at 13 weeks of pregnancy. A 29-year-old woman with a spontaneous 13-week singleton pregnancy presented with hirsutism and a pelvic mass. Ultrasound showed a viable pregnancy compatible with the gestational age and multiple cystic lesions on both ovaries. Read More

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http://dx.doi.org/10.1016/j.crwh.2018.e00094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350097PMC
January 2019
3 Reads

Age at adiposity rebound in childhood is associated with PCOS diagnosis and obesity in adulthood-longitudinal analysis of BMI data from birth to age 46 in cases of PCOS.

Int J Obes (Lond) 2019 Feb 4. Epub 2019 Feb 4.

Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland.

Background: Adiposity rebound (AR), the second BMI rise in childhood at around the age of 6 years, is associated with obesity and metabolic alteration in later life. Given that polycystic ovary syndrome (PCOS) has a strong metabolic component, early life growth patterns could reveal a risk of PCOS. Thus, we aimed to investigate the associations between age at AR and PCOS diagnosis and BMI later in life. Read More

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http://dx.doi.org/10.1038/s41366-019-0318-zDOI Listing
February 2019
3 Reads

Comprehensive Evaluation of Type 2 Diabetes and Cardiovascular Disease Risk Profiles in Reproductive-Age Women with Polycystic Ovary Syndrome: A Large Canadian Cohort.

J Obstet Gynaecol Can 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics and Gynecology, College of Medicine, University of Saskatchewan, Saskatoon, SK. Electronic address:

Objective: This study compared the prevalence of metabolic syndrome (MetS) and characterized type 2 diabetes (DM2) and cardiovascular disease (CVD) risk profiles between Canadian women with polycystic ovary syndrome (PCOS) and healthy women recruited from the general population. Furthermore, within the PCOS cohort, the study contrasted the CVD and DM2 risk profiles of women with or without MetS.

Methods: Measures of MetS (International Diabetes Federation; National Heart, Lung, and Blood Institute; and the American Heart Association definition), DM2 (Diabetes Canada Clinical Guidelines), and CVD risk factors (Androgen Excess and Polycystic Ovary Syndrome Society statement) were evaluated for 237 women with PCOS (Androgen Excess and PCOS Society definitions) and 42 controls (aged 18-36) in a prospective observational study (Canadian Task Force classification II-2). Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.026DOI Listing
January 2019
2 Reads

Temperament and character differences of patients with polycystic ovary syndrome.

J Gynecol Obstet Hum Reprod 2019 Apr 31;48(4):255-259. Epub 2019 Jan 31.

Adnan Menderes Boulevard (Vatan Road) Fatih, İstanbul, 34093, Turkey; Bezmialem Foundation University Medical Faculty, Department of Psychiatry, Turkey.

Aim: There is an unclear relationship between Polycystic Ovary Syndrome and psychiatric disorders including anxiety and depression. We aimed to evaluate temperamental and personal characteristics of patients with PCOS.

Methods: Fifty patients with PCOS and 41 healthy controls were included in the study. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.01.006DOI Listing
April 2019
4 Reads

Randomised controlled trial to study the efficacy of exercise with and without metformin on women with polycystic ovary syndrome.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 4;234:149-154. Epub 2019 Jan 4.

Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India.

Objectives: 1. To study the efficacy of exercise in improving clinical symptoms, anthropometry, glucose tolerance and laboratory profile in women with Polycystic ovarian syndrome. 2. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.021DOI Listing
March 2019
4 Reads

Functional and endocrine-metabolic oligomenorrhea: proposal of a new diagnostic assessment tool for differential diagnosis in adolescence.

J Pediatr Endocrinol Metab 2019 Feb;32(2):135-142

University of Verona, Verona, Italy.

Background To develop a diagnostic assessment tool, using clinical, biochemical and sonographic markers, to help clinicians in the differential diagnosis of functional oligomenorrhea (FO) and endocrine-metabolic oligomenorrhea (EMO). Methods Sixty-two adolescents with oligomenorrhea without evident hormonal imbalances or severe energy deficit were selected. They were divided into two groups (EMO and FO) and they all underwent the following assessment: physical examination (height, weight, presence of hirsutism or acne), blood exams and transabdominal ultrasonography. Read More

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http://dx.doi.org/10.1515/jpem-2018-0351DOI Listing
February 2019
4 Reads

A rare case of pure testosterone-secreting adrenal adenoma in a postmenopausal elderly woman.

BMC Endocr Disord 2019 Jan 23;19(1):14. Epub 2019 Jan 23.

Department of Endocrinology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, 310003, Hangzhou, China.

Background: Hyperandrogenemia is more common in puberty and reproductive age, but relatively rare in postmenopausal women. Postmenopausal virilization may result from androgen-producing tumors. Androgen-secreting adrenal tumors are rare in clinical practice and are diagnosed as adrenocortical carcinoma, most of which can co-secrete androgen and cortisol. Read More

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http://dx.doi.org/10.1186/s12902-019-0342-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343319PMC
January 2019
2 Reads

Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome.

J Ovarian Res 2019 Jan 21;12(1). Epub 2019 Jan 21.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

Objective: The aim of this study was to determine the effect of vitamin D and probiotic co-administration on mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome (PCOS).

Methods: This randomized, double-blinded, placebo-controlled clinical trial was carried out on 60 subjects, aged 18-40 years old. Subjects were randomly allocated to take either 50,000 IU vitamin D every 2 weeks plus 8 × 10 CFU/day probiotic (n = 30) or placebo (n = 30) for 12 weeks. Read More

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https://ovarianresearch.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s13048-019-0480-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340184PMC
January 2019
8 Reads

Insulin resistance is associated with hirsutism in unselected reproductive-aged women.

Clin Endocrinol (Oxf) 2019 Apr 31;90(4):586-591. Epub 2019 Jan 31.

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Objective: Hirsutism affects 5%-10% of reproductive-aged women worldwide and exhibits clinical importance as a cutaneous manifestation of underlying hyperandrogenism. Racial and genetic factors play roles in manifestation of hirsutism, and the prevalence of hirsutism seems to be low in East Asians. However, the reference value of the modified Ferriman-Gallwey (mFG) score to diagnose hirsutism and the prevalence of hirsutism have not been determined in Korean populations to date. Read More

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http://dx.doi.org/10.1111/cen.13936DOI Listing
April 2019
3 Reads

Oral manifestations in patients and dogs with mucopolysaccharidosis Type VII.

Am J Med Genet A 2019 Mar 17;179(3):486-493. Epub 2019 Jan 17.

Children's Rare Disease Institute, Washington, District of Columbia.

Mucopolysaccharidosis Type VII (MPS7, also called β-glucuronidase deficiency or Sly syndrome; MIM 253220) is an extremely rare autosomal recessive lysosomal storage disease, caused by mutations in the GUSB gene. β-glucuronidase (GUSB) is a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans (GAGs). Patients affected with MPS VII are not able to completely degrade glucuronic acid-containing GAGs, including chondroitin 4-sulfate, chondroitin 6-sulfate, dermatan sulfate, and heparan sulfate. Read More

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http://doi.wiley.com/10.1002/ajmg.a.61034
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http://dx.doi.org/10.1002/ajmg.a.61034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374205PMC
March 2019
23 Reads

The pressing need for standardization in epidemiologic studies of PCOS across the globe.

Gynecol Endocrinol 2019 Jan 16;35(1):1-3. Epub 2019 Jan 16.

d Department of Obstetrics and Gynecology Medical College of Georgia , Augusta University , Augusta , GA , USA.

The polycystic ovary syndrome (PCOS) is a common and important complex endocrine metabolic disorder affecting women mainly in the reproductive age. The prevalence of the disorder varies depending on the epidemiologic design and criterion used to study the disease. This variation in methodology and subsequent effect on epidemiologic estimate makes it difficult to compare prevalences and phenotypes across geographical areas and assess the effect of cultural and racial variations on PCOS phenotypes. Read More

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http://dx.doi.org/10.1080/09513590.2018.1488958DOI Listing
January 2019
6 Reads

Hyperandrogenism in a Postmenopausal Woman Secondary to Testosterone Secreting Ovarian Stromal Tumor with Acoustic Schwannoma.

Case Rep Endocrinol 2018 5;2018:8154513. Epub 2018 Dec 5.

Division Director, Department of Endocrinology, Berkshire Medical Center, Pittsfield, MA, USA.

Androgen-secreting ovarian neoplasms are rare ovarian tumors that present with hirsutism and virilization which may manifest as severe alopecia, deepening of voice, and clitoromegaly. Most often, ovarian tumors are found to be very small or even undetectable. In such cases, bilateral salpingo-oophorectomy should be performed after ruling out other causes of high androgens. Read More

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http://dx.doi.org/10.1155/2018/8154513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304522PMC
December 2018
4 Reads

Establishment of reference intervals for serum concentrations of androstanediol glucuronide by a newly developed LC-MS/MS method.

Steroids 2019 Mar 6;143:62-66. Epub 2019 Jan 6.

Department of Clinical Chemistry, University of Liège, CHU Sart-Tilman, Liège, Belgium.

Background: Androstanediol glucuronide is linked to a range of disorders of peripheral androgen formation and action, such as in hirsutism and acne. Nowadays its accurate quantification is still challenging and there are just a few LC-MS/MS methods available. Besides, their reference intervals for normal European populations by LC-MS/MS, including prepubertal and pubertal children, have not been reported yet. Read More

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http://dx.doi.org/10.1016/j.steroids.2018.12.008DOI Listing
March 2019
3 Reads

Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases.

Climacteric 2019 Jan 9:1-5. Epub 2019 Jan 9.

d Department of Internal Medicine (South), Faculty of Medicine , Universidad de Chile , Santiago , Chile.

Postmenopausal hyperandrogenism constitutes a very rare condition of tumoral or non-tumoral origin primarily residing either in the ovary or in the adrenal glands. We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. Read More

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http://dx.doi.org/10.1080/13697137.2018.1549214DOI Listing
January 2019
3 Reads

Grading of hirsutism based on the Ferriman-Gallwey scoring system in Kosovar women.

Postepy Dermatol Alergol 2018 Dec 13;35(6):631-635. Epub 2018 Nov 13.

Department of Physiology and Immunology, Medical Faculty, University of Prishtina, Prishtina, Kosovo.

Introduction: Hirsutism is defined as excess terminal hair that commonly appears in a male pattern in women.

Aim: To examine severity and distribution of hirsutism with Ferriman-Gallwey visual scoring system in hirsute women in Kosovo.

Material And Methods: This prospective study included 160 women, 135 with hirsutism and 25 as a control group. Read More

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http://dx.doi.org/10.5114/ada.2018.77615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320479PMC
December 2018
2 Reads

First case of Rubinstein-Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene.

Clin Exp Dermatol 2019 Jan 6. Epub 2019 Jan 6.

Department of Dermatology, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.

Rubinstein-Taybi syndrome (RSTS) is a rare congenital disorder, mainly characterized by postnatal growth retardation, intellectual disability, and facial and limb abnormalities. Although not considered as characteristic manifestations, numerous cutaneous anomalies have also been reported in patients with RSTS while there has been no report of desquamation so far in any patients with RSTS. We report an unusual case of RSTS in an 8-year-old boy who presented with the typical facial and limb abnormalities of RSTS accompanied with apparent hirsutism and desquamation, but without apparent intellectual disability. Read More

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http://doi.wiley.com/10.1111/ced.13871
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http://dx.doi.org/10.1111/ced.13871DOI Listing
January 2019
13 Reads

Overview of systematic reviews of non-pharmacological interventions in women with polycystic ovary syndrome.

Hum Reprod Update 2019 Mar;25(2):243-256

Women's Health Research Unit, The Blizard Institute, Queen Mary University of London, London, UK.

Background: Polycystic ovary syndrome (PCOS) is a major contributor to subfertility, diabetes and cardiovascular disease in women. The role of non-pharmacological interventions to prevent these outcomes has been reported in many systematic reviews, but robust conclusions have not been made due to variations in the scope, quality and findings of these reviews.

Objective And Rationale: Our aim was to provide an overview of existing evidence on the effects of non-pharmacological interventions in women with PCOS on fertility and non-fertility outcomes by a review of existing systematic reviews. Read More

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http://dx.doi.org/10.1093/humupd/dmy045DOI Listing
March 2019
4 Reads

The efficacy and use of finasteride in women: a systematic review.

Int J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Department of Dermatology, University of California, Irvine, Irvine, CA, USA.

Background: Physicians are beginning to use finasteride as treatment for hair loss, hirsutism, and various other dermatologic conditions in women. However, the reported efficacy and use of finasteride in the female population varies widely. The purpose of this study is therefore to better define the efficacy and use of finasteride in women and identify research gaps that require further investigation. Read More

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http://dx.doi.org/10.1111/ijd.14370DOI Listing
January 2019
4 Reads

Oral Contraceptives and Antiandrogens Most Effective for Hirsutism Pharmacotherapy.

Authors:
Mark H Ebell

Am Fam Physician 2019 Jan;99(1):55

University of Georgia, Athens, GA, USA.

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January 2019
7 Reads

Cushing's syndrome with no clinical stigmata - a variant of glucocorticoid resistance syndrome.

Clin Diabetes Endocrinol 2018 18;4:23. Epub 2018 Dec 18.

3PeaceHealth Southwest Medical Center Diabetes Endocrine & Nutrition, 400 NE Mother Joseph Place, Vancouver, WA 98664 USA.

Background: Cortisol resistance syndrome is a very rare condition characterized by high cortisol levels, but without any clinical features of Cushing's syndrome. Our objective is to present such a case.

Case Presentation: A 41 year old female presented with mild hirsutism and elevated urinary cortisol levels. Read More

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http://dx.doi.org/10.1186/s40842-018-0072-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299537PMC
December 2018
2 Reads

Reproductive Assessment: Findings from 20 Years of the Tehran Lipid and Glucose Study.

Int J Endocrinol Metab 2018 Oct 20;16(4 Suppl):e84786. Epub 2018 Oct 20.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.

Context: Reproductive domains of the Tehran lipid and glucose study (TLGS) are unique in that they provide reliable information on reproduction of an urban population of West Asia. The aim of this review is to present the most important reproductive findings of TLGS.

Evidence Acquisition: This review is summarizing all articles published in the context of reproductive aspects of TLGS results over the 20-year follow-up. Read More

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http://dx.doi.org/10.5812/ijem.84786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289318PMC
October 2018
6 Reads

Peripheral primitive neuroectodermal tumor associated with paraneoplastic Cushing's syndrome: The rare case.

Ann Med Surg (Lond) 2019 Jan 29;37:21-24. Epub 2018 Nov 29.

Iran University of Medical Science, Tehran, Iran.

Introduction: Primitive neuroectodermal tumors (PNET) form a group of tumors defined by their appearance that are thought to develop from primitive (undifferentiated) nerve cells in the brain. They are rare tumors and their incidence is not well defined.

Case Presentation: An 18-month-old male presenting with typical Cushingoid appearance (moon face, central obesity, hirsutism and growth arrest) was admitted for evaluation of endocrine problems. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287080PMC
January 2019
2 Reads