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    [Exploration of the meridian differentiation law in polycystic ovarian syndrome of hirsutism based on data mining technology].
    Zhongguo Zhen Jiu 2018 Feb;38(2):165-73
    Dongfang Hospital of Beijing University of CM, Beijing 100078, China.
    Objective: To analyze the distribution characteristics of hirsutism and the law of meridian differentiation in polycystic ovarian syndrome (PCOS).

    Methods: For the patients of PCOS, the modified Ferriman-Gallwey score (mF-G score) was adopted to evaluate the hirsutism distribution. The clementine data mining software was used to analyze the distribution region of hirsutism and the correlation with meridian. Read More

    Adverse effects of doping with anabolic androgenic steroids (AAS) in competitive athletics, recreational sports and bodybuilding.
    Minerva Endocrinol 2018 Feb 19. Epub 2018 Feb 19.
    Centre of Reproductive Medicine and Andrology, University Hospital Münster, Muenster, Germany -
    Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. Read More

    The Diagnostic Value of Anti-Mullerian Hormone in Early Post Menarche Adolescent Girls with Polycystic Ovarian Syndrome.
    J Pediatr Adolesc Gynecol 2018 Feb 17. Epub 2018 Feb 17.
    Department of Pediatric Endocrinology, Ankara University School of Medicine, Ankara, Turkey.
    Study Objective: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and chronic anovulation, which affects 5-10% of reproductive age females. Diagnosis of adult patients with PCOS is made easily with clinical and laboratory methods and the antimullerian hormone (AMH) level are accepted as a good indicator. However, there is still no complete consensus on the diagnosis of PCOS in adolescents. Read More

    Para-ovarian adrenal rest tumors: gynecologic manifestations of untreated congenital adrenal hyperplasia.
    Gynecol Endocrinol 2018 Feb 20:1-3. Epub 2018 Feb 20.
    d Department of Gynecology Oncology , University of California Irvine , Orange , CA , USA.
    Congenital adrenal hyperplasia (CAH) is an inherited disorder of adrenal steroidogenesis often diagnosed in infancy. Gynecologists may encounter adult patients with CAH due to the clinical effects of increased androgens, e.g. Read More

    Effects of combined oral contraceptives on the clinical and biochemical parameters of hyperandrogenism in patients with polycystic ovary syndrome: a systematic review and meta-analysis.
    Eur J Contracept Reprod Health Care 2018 Feb 19:1-14. Epub 2018 Feb 19.
    b Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences , Shahid Beheshti University of Medical Sciences , Tehran , Iran.
    Introduction: Nowadays, selection of COCs with maximum antiandrogenic effects is one the main issues in treatment of women with polycystic ovary syndrome (PCOS).

    Objective: This systematic review and meta-analysis aimed to compare the effects of COCs on the clinical and biochemical parameters of hyperandrogenism (HA) in patients with PCOS.

    Methods: Electronic databases (PubMed, Scopus, ScienceDirect and web of science) were searched from 1987 to November 2015 to identify clinical trials investigating effect of the various COCs on the clinical and biochemical parameters of HA in patients. Read More

    Adult-onset acne: prevalence, impact, and management challenges.
    Clin Cosmet Investig Dermatol 2018 1;11:59-69. Epub 2018 Feb 1.
    Paulista Medical School, Universidade Federal de São Paulo (Federal University of São Paulo), São Paulo, SP, Brazil.
    Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. Read More

    Non-targeted profiling of circulating microRNAs in women with polycystic ovary syndrome (PCOS): effects of obesity and sex hormones.
    Metabolism 2018 Feb 1. Epub 2018 Feb 1.
    Diabetes Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. Electronic address:
    Purpose: Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules that influence gene transcription. We conducted the present profiling study to characterize the expression of circulating miRNAs in lean and obese patients with polycystic ovary syndrome (PCOS), the most common endocrine and metabolic disorder in premenopausal women.

    Basic Procedures: We selected 11 control women, 12 patients with PCOS and 12 men so that they were similar in terms of body mass index. Read More

    Diagnostic evaluation, comorbidity screening, and treatment of Polycystic Ovary Syndrome in adolescents in three specialty clinics.
    J Pediatr Adolesc Gynecol 2018 Jan 31. Epub 2018 Jan 31.
    Section of Adolescent Medicine and Sports Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.
    Study Objective: A polycystic ovary syndrome (PCOS) diagnosis in adolescence can have significant long-term health implications. The criteria for its diagnosis in adolescents have been subject to much debate. This study aimed to characterize the variability in diagnosis and management among different pediatric specialties. Read More

    Association between severity of depression and clinico-biochemical markers of polycystic ovary syndrome.
    Electron Physician 2017 Nov 25;9(11):5820-5825. Epub 2017 Nov 25.
    M.D., Endocrinologist, Associate Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
    Background: Polycystic ovary syndrome (PCOS), as the most common endocrine disorder among reproductive-aged women may lead to psychological morbidity.

    Objectives: The present study set out to evaluate the severity of depression in PCOS and non-PCOS women and to evaluate correlation between depression score with body mass index, HOMA-IR, and testosterone level in every group (PCOS and non-PCOS women) in Yazd province.

    Methods: In this cross-sectional study, 62 women with PCOS and 61 non- PCOS subjects (20 to 40 years) who were attending Imam-Ali Clinic in Yazd, Iran from September 2014 through March 2015 participated. Read More

    Two mutations in the thiazide-sensitive NaCl co-transporter gene in a Romanian Gitelman syndrome patient: case report.
    Ther Clin Risk Manag 2018 22;14:149-155. Epub 2018 Jan 22.
    Department of Functional Sciences.
    Background: Gitelman syndrome (GS) is considered as the most common renal tubular disorder, and we report the first Romanian patient with GS confirmed at molecular level and diagnosed according to genetic testing.

    Patient And Methods: This paper describes the case of a 27-year-old woman admitted with severe hypokalemia, slight hypomagnesemia, hypocalcemia, hypocalciuria, metabolic alkalosis, hyperreninemia, low blood pressure, limb muscle weakness, marked fatigue and palpitations. Family history revealed a consanguineous family with autosomal-recessive transmission of GS with two cases over five generations. Read More

    Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data.
    Interdiscip Sci 2018 Jan 30. Epub 2018 Jan 30.
    Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
    5-Alpha-reductase 2 is an interesting pharmaceutical target for the treatment of several diseases, including prostate cancer, benign prostatic hyperplasia, male pattern baldness, acne, and hirsutism. One of the main approaches in computer aided drug design is structure-based drug discovery. However, the experimental 3D structure of 5-alpha-reductase 2 is not available at present. Read More

    Gut Microbial Diversity in Women with Polycystic Ovary Syndrome Correlates with Hyperandrogenism.
    J Clin Endocrinol Metab 2018 Jan 23. Epub 2018 Jan 23.
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA, USA.
    Context: A majority of women with polycystic ovary syndrome (PCOS) have metabolic abnormalities that result in an increased risk of developing type 2 diabetes and heart disease. Correlative studies have shown an association between changes in the gut microbiome and metabolic disorders. Two recent studies reported a decrease in alpha diversity of the gut microbiome in women with PCOS compared with healthy women. Read More

    New perspectives on the definition and management of polycystic ovary syndrome.
    J Endocrinol Invest 2018 Jan 23. Epub 2018 Jan 23.
    Unit of Endocrinology, S. Orsola-Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy.
    Background: There is a growing debate on the opportunity of improving the understanding in the diagnosis and management of polycystic ovary syndrome (PCOS).

    Objective: This review article summarizes recent research related to the definition of polycystic ovary syndrome (PCOS).

    Methods: Review of the recent literature on the topic. Read More

    Understanding and Addressing Hair Disorders in Transgender Individuals.
    Am J Clin Dermatol 2018 Jan 19. Epub 2018 Jan 19.
    Department of Dermatology, The Permanente Medical Group, 975 Sereno Drive, Vallejo, CA, 94589, USA.
    In the United States, an increasing number of individuals are identifying as transgender. Males at birth who identify as females are called male-to-female (MTF) transgender individuals or trans women, and females at birth who identify as males are called female-to-male (FTM) transgender individuals or trans men. The transgender patient population possess unique health concerns disparate from those of the general populace. Read More

    Cantú syndrome with coexisting familial pituitary adenoma.
    Endocrine 2018 Mar 11;59(3):677-684. Epub 2018 Jan 11.
    Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
    Context: Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome.

    Case Description: We present a three-generation family with 5 affected members, with marked acromegaloid facies and prominent hypertrichosis, due to a novel missense variant in the ABCC9 gene. Read More

    Head to head comparison of adverse effects and efficacy between high dose deflazacort and high dose prednisolone in systemic lupus erythematosus: a prospective cohort study.
    Lupus 2018 Jan 1:961203317751854. Epub 2018 Jan 1.
    1 Department of Clinical Immunology and Rheumatology, 30025 Christian Medical College, Vellore , India.
    Background Deflazacort (DFZ), an oxazoline derivative of prednisolone (PDN), has a dose equivalence of 1.2:1 (mg) to PDN. No study to date has compared adverse effects and efficacy of high doses of DFZ as against high-dose PDN in systemic lupus erythematosus (SLE). Read More

    A de novo nonsense mutation in ASXL3 shared by siblings with Bainbridge-Ropers syndrome.
    Cold Spring Harb Mol Case Stud 2018 Jan 5. Epub 2018 Jan 5.
    Institute for Genomic Medicine at Nationwide Children's Hospital.
    Two sisters (ages 16 y. and 15 y.) have been followed by our clinical genetics team for several years. Read More

    Combined oral contraceptives and/or antiandrogens versus insulin sensitizers for polycystic ovary syndrome: a systematic review and meta-analysis.
    Hum Reprod Update 2017 Dec 27. Epub 2017 Dec 27.
    Department of Endocrinology & Metabolism, Hospital Universitario Ramón y Cajal & Universidad de Alcalá, E-28034 Madrid, Spain.
    Background: Androgen excess is a key pathogenetic mechanism in polycystic ovary syndrome (PCOS), although hyperinsulinism also contributes to androgen secretion. Therapeutic approaches for adult patients not seeking fertility include combined oral contraceptives (COC), antiandrogens (AA) and/or insulin sensitizers, although these practices are supported by limited high-quality evidence.

    Objective And Rationale: We aimed to assess the efficacy and safety of these common treatments for PCOS by conducting a meta-analysis of RCTs with the following review questions: Which is the more appropriate therapeutic approach for hyperandrogenic symptoms, hyperandrogenemia, and ovulatory dysfunction in adult women with PCOS not seeking fertility; What is the impact on classic cardiometabolic risk factors of the more common treatments used in those women; Does the combination of the antiandrogenic therapy plus metformin have any impact on efficacy or cardiometabolic profile?

    Search Methods: We searched PubMed and EMBASE for articles published up to 16 September 2017. Read More

    Pathomechanisms of polycystic ovary syndrome: Multidimensional approaches.
    Front Biosci (Elite Ed) 2018 Mar 1;10:384-422. Epub 2018 Mar 1.
    Department of Molecular Endocrinology, National Institute for Research in Reproductive Health (ICMR), J.M. Street, Parel, Mumbai, India, 400012,
    Polycystic ovary syndrome is a complex endocrine disorder affecting numerous women of reproductive age across the globe. Characterized mainly by irregular menses, hirsutism, skewed LH: FSH ratios and bulky polycystic ovaries, this multifactorial endocrinopathy results in unfavorable reproductive and metabolic sequelae, including anovulatory infertility, type 2 diabetes, metabolic syndrome and cardiovascular disease in later years. Increasing evidence has shown that the manifestation of polycystic ovary syndrome (PCOS) is attributable to a cumulative impact of altered genetic, epigenetic and protein profiles which bring about a systemic dysfunction. Read More

    UBE2A deficiency in two siblings: A novel splicing variant inherited from a maternal germline mosaicism.
    Am J Med Genet A 2018 Mar 28;176(3):722-726. Epub 2017 Dec 28.
    Dipartimento di Biochimica, Biofisica e Patologia Generale, Università degli Studi della Campania "Luigi Vanvitelli,", Naples, Italy.
    UBE2A deficiency is a syndromic condition of X-linked intellectual disability (ID) characterized by typical dysmorphic features that include synophrys, prominent supraorbital ridges, almond-shaped, and deep-set eyes, large ears, wide mouth, myxedematous appearance, hirsutism, micropenis, and onychodystrophy. To date, only seven familial UBE2A intragenic mutations and nine larger microdeletions encompassing UBE2A have been reported. Here, we describe two siblings with X-linked ID and typical clinical features of UBE2A deficiency caused by a novel hemizygous variant, identified by massively parallel sequencing of X-exome. Read More

    What is adolescent polycystic ovary syndrome?
    J Paediatr Child Health 2017 Dec 27. Epub 2017 Dec 27.
    SA Pathology, Women's and Children's Hospital, Adelaide, South Australia, Australia.
    The diagnostic criteria for adolescent polycystic ovary syndrome (PCOS) has been derived from adult criteria, which makes diagnosis challenging as criteria include normal physiological events that occur during puberty such as acne, hirsutism, menstrual irregularities, high androgen levels and polycystic ovarian morphology on pelvic ultrasound. The only criteria that applies from the adult criteria is exclusion of other conditions that mimic PCOS. Clinical findings consistent with hyperandrogenaemia during adolescence include inflammatory acne, hirsutism, alopecia and/or menstrual irregularities, which are severe and present 2 years after menarche. Read More

    Congenital Generalized Lipodystrophy Type 2 in a Patient From a High-Prevalence Area.
    J Endocr Soc 2017 Aug 26;1(8):1012-1014. Epub 2017 Jun 26.
    Endocrinology Unit, Dos De Mayo Hospital, Lima, Peru (051) 15072.
    Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disease characterized by the loss of body fat. The global prevalence of CGL is one in 10 million, and there are four subtypes. The case is presented of a 18-year-old woman from rural area of the north coast of Peru (Piura) with limited access to health services. Read More

    A Liquid Chromatography/Tandem Mass Spectometry Profile of 16 Serum Steroids, Including 21-Deoxycortisol and 21-Deoxycorticosterone, for Management of Congenital Adrenal Hyperplasia.
    J Endocr Soc 2017 Mar 10;1(3):186-201. Epub 2017 Feb 10.
    Assistance Publique Hôpitaux de Paris (APHP), Hôpitaux Universitaires Est Parisien, Département PM2, Plateforme de Métabolomique, Peptidomique et de Dosage de Médicaments, and.
    Context: Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase deficiency (CAH21) is most often diagnosed by newborn screening. The classic parameter studied is 17-hydroxy-progesterone, but the positive predictive value for the diagnosis of CAH is low in full-term newborns and even lower in preterm newborns.

    Objective: To evaluate the diagnostic utility of simultaneously quantifying a large number of steroids by using liquid chromatography/tandem mass spectrometry (LC-MS/MS) from a small serum volume in patients with CAH, particularly during the neonatal period. Read More

    Evaluation of prolonged use of statins on the clinical and biochemical abnormalities and ovulation dysfunction in single young women with polycystic ovary syndrome.
    Gynecol Endocrinol 2017 Dec 19:1-8. Epub 2017 Dec 19.
    b Microbiology and Immunology Department , Fayoum University College of Medicine , Fayoum , Egypt.
    Objective: The aim of the current work was to investigate the effects of prolonged use of Statins on the clinical and biochemical abnormalities and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS).

    Patients And Methods: It was a randomized, double-blind, placebo-controlled study. Where 200 single young women with PCOS were randomized into either 100 (n = 100) women using Simvastatin 20 mg daily considered as group A (study group), or 100 (n = 100) women using placebo and considered as group B (control group), for six months treatment period. Read More

    Cutaneous manifestations of obesity and themetabolic syndrome.
    Clin Dermatol 2018 Jan - Feb;36(1):81-88. Epub 2017 Sep 8.
    Department of Dermatology, Istanbul Medeniyet University School of Medicine, Istanbul, Turkey.
    The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis, psoriasis, hidradenitis suppurativa, acne, and hirsutism. Being aware of such clinical signs and the underlying systemic disorders may facilitate earlier diagnoses, thereby permitting earlier of therapy initiation and prevention of long-term sequelae. In this process, dermatologists are key figures in the early detection of MetS and its clinical manifestations. Read More

    Characteristic dysmorphic features in congenital disorders of glycosylation type IIb.
    J Hum Genet 2017 Dec 13. Epub 2017 Dec 13.
    Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
    Over 100 types of congenital disorders of glycosylation (CDG) have been reported and the number is rapidly increasing. However, each type is very rare and is problematic to diagnose. Mannosyl-oligosaccharide glucosidase (MOGS)-CDG (CDG type IIb) is an extremely rare CDG that has only been reported in three patients from two unrelated families. Read More

    Combined Oral Contraception and Bicalutamide in Polycystic Ovary Syndrome and Severe Hirsutism - a Double-blind RTC.
    J Clin Endocrinol Metab 2017 Dec 1. Epub 2017 Dec 1.
    Department of Experimental Medicine, Unit of Endocrinology, "Policlinico Umberto I" Hospital, University of Rome La Sapienza, Rome, Italy.
    Background: Hirsutism is frequently expressed in women affected by polycystic ovary syndrome (PCOS). The efficacy of oral contraceptive pill (OC) plus anti-androgens in the treatment of its severe expression is controversial due to the lack of randomized double-blind long-term studies.

    Aim: The primary outcome was the reduction of hirsutism in PCOS women objectively measured by videodermoscopy (VD) on the androgen-sensitive skin areas assessed by the modified Ferriman&Gallwey (mF&G) total score, after 12 months of therapy with OC+Bicalutamide (BC) versus OC plus placebo (P). Read More

    The Contribution of New Areas to the Total Hirsutism Scores in Basrah Hirsute Women.
    Diseases 2017 Nov 27;5(4). Epub 2017 Nov 27.
    Department of Medicine, Basrah College of Medicine, Basrah 61013, Iraq.
    Background: Hirsutism is the presence of excessive growth of terminal hair in a female in the male-like pattern. It is the most common indicator of hyperandrogenism. The primary objective of this study was to evaluate the clinical impact of new androgens sensitive skin area to total body hirsutism score. Read More

    Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome.
    Nutrients 2017 11 24;9(12). Epub 2017 Nov 24.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan 8715988141, Iran
    This study was carried out to evaluate the effects of vitamin D supplementation on the metabolic profiles of insulin-resistant subjects with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted on 90 insulin-resistant women with PCOS. Participants were randomly assigned to three groups to intake either 4000 IU of vitamin D or 1000 IU of vitamin D or placebo (= 30 each group) daily for 12 weeks. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    Polycystic ovary syndrome in adolescence: diagnostic and therapeutic strategies.
    Transl Pediatr 2017 Oct;6(4):248-255
    Section of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, the Ohio State University College of Medicine, Columbus, OH, USA.
    Controversy continues about the underlying etiopathogenesis, diagnostic criteria, and recommendations for polycystic ovary syndrome (PCOS) in adolescents. Recent literature has recognized these deficiencies and evidence based expert recommendations have become more available. The purpose of this chapter is to offer primary care providers a practical understanding and approach to the diagnosis and treatment of PCOS in adolescents. Read More

    A diagnostic curiosity of isolated androstenedione elevation due to autoantibodies against horseradish peroxidase label of the immunoassay.
    Clin Chim Acta 2018 Jan 23;476:103-106. Epub 2017 Nov 23.
    Division of Paediatric Endocrinology and Diabetes, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore.
    Two sisters with hirsutism presented with mild hirsutism and isolated, grossly elevated (>34.9nmol/L) serum concentrations of androstenedione measured by competitive, homogeneous immunoassay. The clinically discordant laboratory results prompted us to look for assay interference. Read More

    Combined ovarian and adrenal venous sampling in the localization of ACTH-independent ectopic Cushing's syndrome.
    J Clin Endocrinol Metab 2017 Nov 16. Epub 2017 Nov 16.
    Department of Endocrinology, Endocrine Key Laboratory of Ministry of Health, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.
    Context: Cushing's syndrome is rarely caused by the secretion of cortisol from the ovarian tumors. It is important to determine whether the ovarian tumor is capable of secreting cortisol or not in clinical decision making. Selective ovarian and adrenal venous sampling has not been reported previously in the localization of ACTH-independent ectopic Cushing's syndrome. Read More

    An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
    Horm Res Paediatr 2017 13;88(6):371-395. Epub 2017 Nov 13.
    Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania, USA.
    This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)1. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Read More

    [Treatments of steroid-dependent nephrotic syndrome in children].
    Arch Pediatr 2017 Dec 13;24(12):1312-1320. Epub 2017 Nov 13.
    Service de néphrologie pédiatrique, centre de référence du syndrome néphrotique idiopathique, institut Imagine, université Paris Descartes, hôpital Necker-Enfants-Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.
    Primary nephrotic syndrome (NS) is the most common glomerular disease in children. It is characterized by massive proteinuria and hypoalbuminemia. It typically has a sudden onset and more than 70% of patients will experience at least one relapse. Read More

    Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study.
    Epilepsy Res 2018 Jan 28;139:20-27. Epub 2017 Oct 28.
    Department of Pharmacology, M.M. Institute of Medical Sciences and Research, M.M. University, Ambala, India.
    Objective: To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy.

    Methods: Reproductive hormonal profiles, hirsutism, ovarian morphology by ultrasonography and menstrual cycle data in newly diagnosed women with epilepsy taking VPA (n=34) or LTG (n=32) monotherapy were compared. None of the women were receiving hormonal contraception. Read More

    Postoperative Complications of Dermis-Fat Autografts in the Anophthalmic Socket.
    Semin Ophthalmol 2018 16;33(1):112-115. Epub 2017 Nov 16.
    a Ophthalmic Plastic Surgery Service, Department of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA , USA.
    Reconstruction of the anophthalmic socket allows the use of an ocular prosthesis and rehabilitation of facial appearance. Dermis-fat grafting is one option in volume augmentation of the anophthalmic socket and presents unique benefits, including increased surface area within the socket and the ability to grow with pediatric patients. Postoperative complications of this procedure are relatively common. Read More

    Ovarian surgery for symptom relief in women with polycystic ovary syndrome.
    Cochrane Database Syst Rev 2017 11 10;11:CD009526. Epub 2017 Nov 10.
    Department of Obstetrics and Gynaecology, Capital and Coast District Health Board, Wellington, New Zealand.
    Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition, affecting approximately one in 10 women. PCOS is defined by two of three features: oligo- or anovulation, clinical or biochemical hyperandrogenism or both, or polycystic ovaries.Women with PCOS can have a wide range of health problems, including infrequent and irregular periods, unwanted hair growth and acne, and subnormal fertility. Read More

    Outcomes of oral lichen planus and oral lichenoid lesions treated with topical corticosteroid.
    Oral Dis 2017 Nov 9. Epub 2017 Nov 9.
    School of Dentistry, Instituto de Biomedicina de Granada, University of Granada, Granada, Spain.
    Objective: To determine corticosteroid treatment effectiveness in patients with oral lichen planus/oral lichenoid lesions (OLP/OLL).

    Material And Methods: Twenty-one patients with OLP and eighty-one patients with OLL received 0.05% clobetasol propionate (CP) or 0. Read More

    Very low dose of flutamide in the treatment of hyperandrogenism.
    Gynecol Endocrinol 2017 Nov 6:1-5. Epub 2017 Nov 6.
    a Department of Obstetric and Gynecology , Univ di Cagliari , Cagliari , Italy.
    Hyperandrogenism is a condition affecting 5-10% of adolescents. The aim of this study was to evaluate the efficacy of very low dose of flutamide in the treatment of hyperandrogenism in adolescence. One hundred and fifty-eight patients, presenting severe acne and/or hirsutism, received 62. Read More

    Homozygous mutation in ELMO2 may cause Ramon syndrome.
    Clin Genet 2017 Nov 2. Epub 2017 Nov 2.
    Institut Jérôme Lejeune, Paris, France.
    We report on a girl, born to first cousin Lebanese parents, with intellectual disability, seizures, repeated gingivorrhagia, enlarged lower and upper jaws, overgrowth of the gums, high arched and narrow palate, crowded teeth, hirsutism of the back, large abdomen and a small umbilical hernia. Cysts of the mandible, fibrous dysplasia of bones, and enlarged adenoids causing around 60% narrowing of the nasopharyngeal airways were noted at radiographic examination. Her brother presented with the same features in addition to a short stature, an ostium secundum, and more pronounced intellectual disability. Read More

    Can laser treatment improve quality of life of hirsute women?
    Int J Womens Health 2017 19;9:777-780. Epub 2017 Oct 19.
    Dermatology Department, School of Medicine, Guilan University of Medical Sciences.
    Background: Hirsutism can have negative impacts on psychosocial aspects of women's lives and reduce their quality of life (QOL). The aim of this study was to assess the QOL of these women during laser treatment.

    Patients And Methods: Eighty-eight women with unwanted facial hair underwent laser therapy. Read More

    No. 350-Hirsutism: Evaluation and Treatment.
    J Obstet Gynaecol Can 2017 Nov;39(11):1054-1068
    Ottawa, ON.
    Objectives: To review the etiology, evaluation, and treatment of hirsutism.

    Evaluation: A thorough history and physical examination plus selected laboratory evaluations will confirm the diagnosis and direct treatment.

    Treatment: Pharmacologic interventions can suppress ovarian or adrenal androgen production and block androgen receptors in the hair follicle. Read More

    The impact of combined oral contraceptives on ocular tissues: a review of ocular effects.
    Int J Ophthalmol 2017 18;10(10):1604-1610. Epub 2017 Oct 18.
    Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, Greece.
    The aim of this manuscript is to review the action and adverse effects of combined oral contraceptives (COCs) on ocular tissues. The percentage of unwanted pregnancies and the subsequent abortions make contraception crucial worldwide. Over 100 million women around the world use common contraceptive methods, including intrauterine devices, combined estrogen and progestin oral contraceptives, as well as progestin only preparations (oral contraceptives, implants or injections). Read More

    Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life.
    FASEB J 2018 Feb 4;32(2):795-806. Epub 2018 Jan 4.
    Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom.
    Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs ( e. Read More

    Testosterone Pellet Associated Dermatitis: Report and Review of Testopel-related Cutaneous Adverse Effects.
    Cureus 2017 Aug 11;9(8):e1560. Epub 2017 Aug 11.
    Department of Dermatology, University of California, San Diego.
    Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. Read More

    Laser-assisted hair removal for facial hirsutism in women: A review of evidence.
    J Cosmet Laser Ther 2017 Oct 11:1-5. Epub 2017 Oct 11.
    a Department of Dermatology , Frimley Park hospital NHS Foundation Trust , Camberley , UK.
    Poly cystic ovarian syndrome (PCOS) has been described as the common diagnosis for hirsutism in women. Facial hirsutism is by far the most distressing symptom of hyperandrogenism in women with PCOS. A statistically significant improvement in psychological well-being has been reported in patients with PCOS allocated for laser-assisted hair removal. Read More

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