6,208 results match your criteria Hirsutism


Higher luteinizing hormone levels associated with antimüllerian hormone in postmenarchal daughters of women with polycystic ovary syndrome.

Fertil Steril 2018 Dec 6. Epub 2018 Dec 6.

Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile.

Objective: To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche.

Design: Case-control study.

Setting: Clinical endocrinology unit. Read More

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December 2018

Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome.

Fertil Steril 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, University of California, Los Angeles, California; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation; Department of Health Policy, Management, and Behavior, School of Public Health, State University of New York, Albany, New York. Electronic address:

Objective: To test the hypothesis that the polycystic ovary syndrome (PCOS) phenotype, or its component features, is less severe in adolescents than in young adult patients, in a referred (clinical) population.

Design: Cross-sectional study.

Setting: Tertiary-care academic medical center. Read More

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December 2018

Managing polycystic ovary syndrome in primary care.

Singapore Med J 2018 Nov;59(11):567-571

Department of Endocrinology, Changi General Hospital, Singapore.

Polycystic ovary syndrome (PCOS) presents with a spectrum of conditions resulting from androgen excess, anovulation and metabolic syndrome. Patients with PCOS may see their primary care physicians for various presentations, including hirsutism, acne, menstrual irregularities, infertility, obesity, and psychiatric disorders such as anxiety and depression. Management of these patients should include screening for Type 2 diabetes mellitus, dyslipidaemia and hypertension. Read More

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November 2018
1 Read

[Hirsutism secondary to a luteal cyst of the right ovary at the department of internal medicine and endocrinology of the Mali Hospital].

Mali Med 2018 ;33(1):35-37

Service de médecine interne et d'endocrinologie de l'hôpital du Mali.

The authors are reporting here for the first time a documented case of androgen-secreting luteal cyst responsible for primary sterility in Mali. A 26-year married woman with a history of familial hyper androgenia of diabetes and high blood pressure who consulted for hyper androgen syndrome and primary infertility. Hirsutism with the presence of hairs on her chin, upper lips, thorax, forearms, arms, and her legs under waxing which made a Ferriman and Galloway scoreof10. Read More

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January 2018
1 Read

Utilisation of gonadotrophin-releasing hormone (GnRH) analogue to differentiate ovarian from adrenal hyperandrogenism in postmenopausal women.

Endocrinol Diabetes Metab Case Rep 2018 Nov 22;2018. Epub 2018 Nov 22.

Endocrinology, South Tipperary General Hospital, Clonmel, Ireland.

Postmenopausal hyperandrogenism is a relatively rare diagnosis resulting from excess androgen production from the adrenals or ovaries. The exclusion of malignant causes is a priority. Laboratory tests and imaging are utilised to help differentiate the source of excess androgens. Read More

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November 2018
10 Reads

Safety of 5α-reductase inhibitors and spironolactone in breast cancer patients receiving endocrine therapies.

Breast Cancer Res Treat 2018 Nov 22. Epub 2018 Nov 22.

Department of Dermatology, Memorial Sloan-Kettering Cancer Center, 16 East 60th Street, Suite 407, 4th Floor, New York, NY, 10022, USA.

Purpose: To provide dermatologists and oncologists with a foundation for practical understanding and uses of 5α-reductase inhibitors and spironolactone for breast cancer patients and survivors receiving endocrine therapies (ETs), including the effect of these treatments on sex hormone levels, any reported drug interactions, and any risk of malignancy.

Methods: All published studies from January 1978 through April 2018 were considered, using databases such as PubMed, Google Scholar, and Science Direct. Forty-seven studies were included in this review. Read More

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November 2018
5 Reads

Geographical Prevalence of Polycystic Ovary Syndrome as Determined by Region and Race/Ethnicity.

Int J Environ Res Public Health 2018 Nov 20;15(11). Epub 2018 Nov 20.

Department of Human Nutrition and Foods, West Virginia University, Morgantown, WV 26506, USA.

Polycystic ovarian syndrome (PCOS) is thought to be the most common endocrine disorder found in women. Common symptoms include irregular menstrual cycle, polycystic ovaries, and hirsutism, as well as an increased risk for a multitude of conditions, including insulin resistance, dyslipidemia and infertility. The prevalence of polycystic ovarian syndrome is generally thought to be between 3% and 10% but it is widely unknown for specific subpopulations based on geographical location and race/ethnicity. Read More

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November 2018
5 Reads

Self-reported Polycystic Ovary Syndrome is Associated with Hypertension: A Northern Finland Birth Cohort 1966 Study.

J Clin Endocrinol Metab 2018 Nov 15. Epub 2018 Nov 15.

Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Medical Research Center, PEDEGO Research Unit, Oulu, Finland.

Context: PCOS is associated with many traditional cardiovascular disease risk factors, but it is unclear whether PCOS is an independent risk factor for hypertension.

Objective: To investigate in a population-based set-up whether PCOS associates with the risk of hypertension independently of body-mass-index (BMI), and with cardiovascular manifestations.

Design: Cross-sectional assessments in the Northern Finland Birth Cohort 1966 at ages 31 and 46. Read More

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November 2018
5 Reads

Diagnostic pitfalls in ovarian androgen-secreting (Leydig cell) tumours: case series.

J Obstet Gynaecol 2018 Nov 14:1-6. Epub 2018 Nov 14.

d Institute of Endocrinology , Prague , Czech Republic.

Leydig cell tumours of the ovary are rare and represent a diagnostic challenge not only due to their sporadic incidence but also due to the seemingly normal imaging. We present three cases of pre- and postmenopausal women who were presented with severe clinical signs of hyperandogenism where modern imaging modalities (including computed tomography (CT), magnetic resonance imaging (MRI) and positron-emission tomography combined with computed tomography (PET-CT)) failed to identify the tumour. Two patients underwent non-expert ultrasound, CT and MRI examination with uniform conclusion that ovaries are of normal appearance. Read More

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November 2018
3 Reads

Effects of Metformin on Symptoms of Polycystic Ovarian Syndrome Among Women of Reproductive Age.

Cureus 2018 Aug 25;10(8):e3203. Epub 2018 Aug 25.

Department of Community Health Sciences, Jinnah Medical and Dental College, Karachi, PAK.

Background Metformin is a highly preferred drug that is used to treat the symptoms of polycystic ovarian syndrome among women. Pakistan is facing a continuous rise in the prevalence of polycystic ovarian syndrome. Therefore, the determination of the effectiveness of the drug in this condition is considered ideal as per the presenting situation. Read More

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August 2018
1 Read

Virilising ovarian tumors: a single center experience.

Endocr Connect 2018 Nov 1. Epub 2018 Nov 1.

N Shah, Mumbai, 400012, India.

Aims: Literature on virilising ovarian tumors (VOT) is limited to case reports and series reporting single pathological type. We have analyzed the clinical, hormonal, radiological, histological, management and outcome data of VOT.

Materials And Methods: This retrospective study was conducted at a tertiary health care center from Western India. Read More

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November 2018
3 Reads

Rare case of occult testosterone-producing ovarian tumor that was diagnosed by selective venous hormone sampling.

Reprod Med Biol 2018 Oct 21;17(4):504-508. Epub 2018 Jun 21.

Department of Obstetrics and Gynecology Sapporo Medical University School of Medicine Sapporo Japan.

Case: A 32 year old woman was referred because of secondary amenorrhea, hirsutism, and voice deepening.

Outcome: The blood testosterone level was markedly high. A transvaginal ultrasound revealed a small region in the left ovary, but whether or not it was a tumor was unclear. Read More

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October 2018
1 Read

Recurrent maternal virilization during pregnancy in patients with PCOS: two clinical cases.

Reprod Biol Endocrinol 2018 Oct 30;16(1):107. Epub 2018 Oct 30.

Service de Gynécologie Endocrinienne et Médecine de la Reproduction, Hôpital Jeanne de Flandre, CHRU Lille, 2 Avenue Eugène Avinée, 59037, Lille, France.

Background: Maternal virilization during pregnancy is a rare phenomenon. Polycystic ovary syndrome (PCOS), luteoma and luteinic cysts are the most frequent and benign etiologies. This article presents two cases of recurrent maternal virilization during pregnancy. Read More

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October 2018
1 Read

Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome.

Endocrinology 2018 Dec;159(12):4056-4064

Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil.

The main clinical feature associated with hyperandrogenism in polycystic ovary syndrome (PCOS) in humans is hirsutism, where hair increases its length, pigmentation, and particularly its diameter. Currently, it is not known whether PCOS animal models also exhibit changes in the hair. Therefore, the aim of this study was to explore the wool characteristics in sheep prenatally androgenized (PA) with testosterone propionate. Read More

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December 2018
4 Reads

Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study.

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

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May 2018
1 Read

The Current Description and Future Need for Multidisciplinary PCOS Clinics.

J Clin Med 2018 Oct 28;7(11). Epub 2018 Oct 28.

Department of Human Nutrition and Foods, West Virginia University, Morgantown, WV 26506, USA.

Polycystic Ovarian Syndrome (PCOS), with common symptoms of irregular menstrual cycles, ovarian cysts, and hirsutism, is thought to be the most common endocrine disorder found in women, and use of multidisciplinary teams has been shown to be effective. The purpose of this review is to determine the future need for specialized, comprehensive, multidisciplinary treatment for PCOS and the current description and efficacy of existing multidisciplinary clinics. The literature was searched using PubMed, CINAHL, PsycINFO, Medline, and the Cochrane Library. Read More

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October 2018
2 Reads

Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial.

Curr Drug Discov Technol 2018 Oct 29. Epub 2018 Oct 29.

Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: The aim of this study was to evaluate the efficacy of the herbal tea based on Foeniculum vulgare, on inducing regular bleeding in women with oligomenorrhea and secondary amenorrhea(oligo/amenorrhea).

Methods: Forty women aged 18- 40 with oligo/amenorrhea were enrolled in this randomized controlled clinical trial and were allocated to two groups equally. The women in the first group were treated by Fomentex (Foeniculum vulgare / Mentha longifolia / Vitex agnus-castus) herbal tea 11. Read More

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October 2018
5 Reads

An Interesting Case of Hepatic Adrenocortical Carcinoma.

Acta Med Indones 2018 Jul;50(3):257-259

Department of Internal Medicine, Faculty of Medicine Universitas Padjadjaran - Hasan Sadikin Hospital, Bandung, Indonesia.

Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1. Read More

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July 2018
5 Reads

Congenital tufted angioma: A multicenter retrospective study of 30 cases.

Pediatr Dermatol 2018 Nov 15;35(6):808-816. Epub 2018 Oct 15.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Background: Recent reports indicate that tufted angioma is a rare vascular neoplasm that manifests more frequently at birth than previously thought. Few studies specifically address congenital presentation.

Objectives: We analyzed the clinicopathological characteristics, clinical course, and treatment of congenital tufted angioma (cTA) and evaluated variables that were indicative of problematic lesions. Read More

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November 2018
6 Reads

Beyond fertility: polycystic ovary syndrome and long-term health.

Fertil Steril 2018 Oct;110(5):794-809

Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with symptoms of oligomenorrhea or hirsutism or when presenting for infertility care. The health risks associated out of PCOS, however, go far beyond management of these common presenting symptoms or fertility treatment and likely extend past the reproductive years through and beyond menopause. Read More

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October 2018
10 Reads

Androgens in Women: Hormone modulating therapies for skin disease (Part II).

J Am Acad Dermatol 2018 Oct 9. Epub 2018 Oct 9.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine. Electronic address:

Androgen-mediated cutaneous disorders (AMCDs) in women including acne, hirsutism, and female pattern hair loss (FPHL) can be treated with hormone-modulating therapies. In the second part of this Continuing Medical Education series, we discuss the hormone-modulating therapies available to dermatologists for the treatment of AMCDs including combined oral contraceptives, spironolactone, finasteride, dutasteride, and flutamide. Available hormone-modulating treatments utilized for each AMCDs are reviewed, along with mechanisms of androgen modulation, safety profile, contraindications, monitoring parameters, and evidence of efficacy. Read More

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October 2018
1 Read

Androgens in Women: Androgen mediated skin disease and patient evaluation (Part I).

J Am Acad Dermatol 2018 Oct 9. Epub 2018 Oct 9.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine. Electronic address:

Androgens are produced throughout the body in steroid-producing organs, such as the adrenal glands and ovaries, as well as in other tissues, like the skin. Several androgens are found normally in women, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), testosterone, dihydrotestosterone (DHT), and androstenedione. These androgens are essential in the development of several common cutaneous conditions in women, including acne, hirsutism, and female pattern hair loss (FPHL) - androgen mediated cutaneous disorders (AMCDs). Read More

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October 2018
2 Reads

Polycystic ovary syndrome and its impact on Iranian women's quality of life: a population-based study.

BMC Womens Health 2018 Oct 11;18(1):164. Epub 2018 Oct 11.

Population Health Research Group, Health Metrics Research Center, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Background: Polycystic ovary syndrome (PCOS) is a major public health concern worldwide affecting up to one in five women at reproductive age. It is associated with biochemical and hormonal disturbances as well as adverse cosmetic, reproductive, metabolic, and psychological consequences, resulting in worsened quality of life. The aim of the present study is evaluating the quality of life and determining its degrading factors among Iranian women suffering from this syndrome. Read More

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October 2018
2 Reads
1.657 Impact Factor

Central Obesity, Faster Maturation, and 'PCOS' in Girls.

Trends Endocrinol Metab 2018 Dec 5;29(12):815-818. Epub 2018 Oct 5.

Pediatric Endocrinology, Research Institute Sant Joan de Déu, University of Barcelona, Barcelona, Spain; CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Polycystic ovary syndrome (PCOS) development commonly starts with a mismatch between pre- and postnatal weight gain, leading to hepatovisceral fat excess. To escape from such central obesity, girls may accelerate their growth and/or maturation. This homeostatic mechanism is lost upon reaching adult height, and PCOS may ensue. Read More

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December 2018
4 Reads

First data from a parent-reported registry of 81 individuals with Coffin-Siris syndrome: Natural history and management recommendations.

Am J Med Genet A 2018 Nov 1;176(11):2250-2258. Epub 2018 Oct 1.

Division of Medical Genetics and Metabolism, Children's Hospital of The King's Daughters, Norfolk, Virginia.

Coffin-Siris syndrome (CSS; MIM 135900) is a multisystem congenital anomaly syndrome caused by mutations in the genes in the Brg-1 associated factors (BAF) complex. Classically, individuals with CSS have been described with hypo- or aplasia of the fifth digit nails or phalanges (hence the term "fifth digit syndrome"). Other physical features seen include growth restriction, coarse facial features, hypertrichosis or hirsutism, sparse scalp hair, dental anomalies, and other organ-system abnormalities. Read More

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November 2018
1 Read

Cross-method comparison of serum androstenedione measurement with respect to the validation of a new fully automated chemiluminescence immunoassay.

Clin Biochem 2018 Dec 24;62:32-38. Epub 2018 Sep 24.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), University Hospital RWTH, Aachen, Germany.

Objectives: Androstenedione is an androgen produced as an intermediate product of the biosynthesis of testosterone and estradiol in testicles, ovaries and also in the adrenal cortex. Measurement is used for diagnosing and differentiating hirsutism and virilisation, enzyme deficiencies of the steroid hormone biosynthesis, and in suspicion of androgen-producing tumors.

Methods: Specimens included de-identified residual serum specimens submitted for routine testing and banked adult and pediatric sera. Read More

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December 2018
3 Reads

Comparison of Androgen Levels, Endocrine and Metabolic Indices, and Clinical Findings in Women with Polycystic Ovary Syndrome in Uygur and Han Ethnic Groups from Xinjiang Province in China.

Med Sci Monit 2018 Sep 25;24:6774-6780. Epub 2018 Sep 25.

Department of Endocrinology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China (mainland).

BACKGROUND The aim of this study was to compare androgen levels, endocrine and metabolic indices, and clinical findings in women with polycystic ovary syndrome (PCOS) in Uygur and Han ethnic groups from Xinjiang Province, China. MATERIAL AND METHODS Between January 2016 to May 2017 clinical data were collected from Uygur (N=82) and Han (N=100) women diagnosed with PCOS, including age, body mass index (BMI), the Ferriman-Gallwey (mFG) hirsutism score, and waist-to-hip ratio (WHR). Blood samples obtained from all study participants were used to measure androgenic steroid levels, including androgen, androstenedione, dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT), and the free androgen index (FAI). Read More

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September 2018
2 Reads

The effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.

J Psychosom Obstet Gynaecol 2018 Sep 19:1-9. Epub 2018 Sep 19.

a Research Center for Biochemistry and Nutrition in Metabolic Diseases , Kashan University of Medical Sciences , Kashan , Iran.

Objective: This study was conducted to evaluate the effects of fish oil omega-3 fatty acid supplementation on mental health parameters and metabolic status of women with polycystic ovary syndrome (PCOS).

Methods: This randomized double-blind, placebo-controlled trial was conducted on 60 women with PCOS, aged 18-40 years old. Participants were randomly assigned into two groups to receive either 2 × 1000 mg/day fish oil omega-3 fatty acid (n = 30) or placebo (n = 30) after lunch for 12 weeks. Read More

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September 2018
2 Reads

The relationship between clinical and biochemical characteristics and quality of life in patients with polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2018 Sep 19. Epub 2018 Sep 19.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objective: While has been well demonstrated that clinical characteristics of polycystic ovary syndrome (PCOS) are associated with an impaired quality of life (QoL) in patients, it is unclear that whether the biochemical aspects of PCOS can influence their QoL. We aimed to investigate the relationship between clinical and biochemical characteristics, and various domains of QoL in patients with PCOS.

Design: A cross-sectional study. Read More

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September 2018
6 Reads

The effects of probiotic and selenium co-supplementation on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome.

J Ovarian Res 2018 Sep 14;11(1):80. Epub 2018 Sep 14.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R., Iran.

Background: The aim of this study was to evaluate the effect of the co-administration of probiotic and selenium on parameters of mental health, hormonal profiles, and biomarkers of inflammation and oxidative stress in women with PCOS. Data on the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters of patients with polycystic ovary syndrome (PCOS) are scarce. This investigation was carried out to evaluate the effects of selenium and probiotic co-supplementation on mental health, hormonal and inflammatory parameters in women with PCOS. Read More

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September 2018
3 Reads

No evidence for a major effect of three common polymorphisms of the GPx1, MnSOD, and CAT genes on PCOS susceptibility.

J Cell Biochem 2018 Sep 11. Epub 2018 Sep 11.

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Kermanshah Province, Iran.

Aim: Polycystic ovary syndrome (PCOS) is one of the prevalent endocrine-metabolic disorders. It is proposed that oxidative stress contributes to PCOS susceptibility and its metabolic associations. The current study aimed to investigate the influence of GPx1 (rs1050450), MnSOD (rs4880), and Catalase (rs1001179) variants with PCOS susceptibility, for the first time. Read More

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September 2018
2 Reads

THE PREVALENCE OF HIRSUTISM AND ETHNICAL PECULIARITIES OF HAIR DISTRIBUTION IN GEORGIAN ADOLESCENT POPULATION IN TBILISI.

Georgian Med News 2018 Jul-Aug(280-281):64-68

Tbilisi State Medical University; David Gagua Clinics Ltd, Tbilisi, Georgia.

Objective - the purpose of the study is evaluation of the Hirsutism prevalence and ethnical peculiarities of the hair distribution in Georgian female adolescents of Tbilisi, Georgia. 2592 randomly selected female adolescents of Tbilisi were included in the study. They completed standard questionnaires consisted of questions about the existence of hirsutism and its locations. Read More

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September 2018
1 Read

UBE2A-related X-linked intellectual disability.

Clin Dysmorphol 2019 Jan;28(1):1-6

Greenwood Genetic Center, Greenwood, South Carolina, USA.

UBE2A-related X-linked intellectual disability is characterized by a distinctive facial phenotype (dense eyebrows and eyelashes, synophrys, hypertelorism, upslanted palpebral fissures, wide mouth, and thin lips), generalized hirsutism, hypoplastic genitalia, short stature, hypotonia, seizures, and severe intellectual disability. Five affected males in two families are described here and compared with the previously reported 17 males in eight families. The new cases are notable for the absence of nail dystrophy, previously considered a defining manifestation, and for the presence of hypogammaglobulinemia and adult-onset ataxia. Read More

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January 2019
7 Reads

Comorbid conditions in lichen planopilaris: A retrospective data analysis of 334 patients.

Int J Womens Dermatol 2018 Sep 7;4(3):180-184. Epub 2018 Jun 7.

Department of Dermatology and Dermatopathology, Cleveland Clinic Foundation, Cleveland, Ohio.

Background: Lichen planopilaris (LPP) is a rare, cicatricial, lymphocyte-mediated alopecia that is thought to have an autoimmune pathogenesis and possibly related to other autoimmune diseases. However, data are limited and studies that examine comorbid conditions are lacking.

Objectives: We sought to determine the prevalence of systemic comorbid conditions, nutritional deficiencies, psychological problems, and skin cancers in patients with LPP. Read More

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September 2018
1 Read

Consensus Statement on the Use of Oral Contraceptive Pills in Polycystic Ovarian Syndrome Women in India.

Authors:

J Hum Reprod Sci 2018 Apr-Jun;11(2):96-118

Objective: To provide consensus recommendations for health-care providers on the use of oral contraceptive pills (OCPs) in polycystic ovarian syndrome (PCOS) women in India.

Participants: Extensive deliberations, discussions, and brainstorming were done with different fraternities (specialists) being involved. These included endocrinologists, gynecologists, reproductive endocrinologists, dermatologists, public health experts, researchers, and a project manager with a team to develop the guideline. Read More

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August 2018
11 Reads

Are Psychosocial Consequences of Obesity and Hyperandrogenism Present in Adolescent Girls with Polycystic Ovary Syndrome?

Int J Endocrinol 2018 25;2018:3269618. Epub 2018 Jul 25.

Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Study Objective: The objective of this study was to evaluate whether body weight status and clinical hyperandrogenism may influence social competencies and psychological gender features in adolescent girls.

Design And Participants: In 104 adolescent girls, psychological gender inventory (PGI) and social competencies questionnaire (SCQ) (assessing social abilities in three aspects: intimacy (I), social exposure (SE), and assertiveness (AS)) were performed. Subjects were divided into four subgroups: G1-24 nonobese girls without hyperandrogenism, G2-18 obese girls without hyperandrogenism, G3-30 nonobese hyperandrogenic girls, and G4-32 obese girls with hyperandrogenism. Read More

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July 2018
10 Reads

New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men.

Adv Clin Chem 2018 18;86:71-125. Epub 2018 Aug 18.

Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of California at Davis, Davis, CA, United States.

Androgens can have variable effects on men and women. Women may be evaluated for androgen excess for several reasons. Typically, young premenopausal women present with clinical symptoms of hirsutism, alopecia, irregular menses, and/or infertility. Read More

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August 2018
15 Reads

Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth.

Int J Cosmet Sci 2018 Oct 4;40(5):429-450. Epub 2018 Oct 4.

Cell Biology Lab, Dabur Research Foundation, 22, Site IV, Sahibabad, Ghaziabad, Uttar Pradesh, 201010, India.

Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. Read More

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October 2018
3 Reads
1.451 Impact Factor

Ovarian granulosa cell tumor and clomiphene citrate resistance. A case report and review of the literature.

JBRA Assist Reprod 2018 Nov 1;22(4):381-384. Epub 2018 Nov 1.

2nd Department of Obstetrics and Gynecology, "Aretaieion" Hospital, University of Athens, Greece.

Granulosa cell tumors (GCTs) account for less than 5% of all ovarian malignancies, occur in younger ages, are usually diagnosed in their early stages, and have a good prognosis. GCTs usually present with features of hyperestrogenism. This paper reports the unusual case of an adult with a GCT with manifestations including amenorrhea, mild hirsutism, infertility, clomiphene citrate (CC) resistance (CC), mildly elevated testosterone, high anti-Müllerian hormone (AMH) and normal estrogen levels. Read More

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November 2018
6 Reads

Primary pigmented nodular adrenocortical disease (PPNAD) as an underlying cause of symptoms in a patient presenting with hirsutism and secondary amenorrhea: case report and literature review.

Gynecol Endocrinol 2018 Aug 21:1-5. Epub 2018 Aug 21.

a Department of Endocrinology, Metabolism and Internal Medicine , Poznan University of Medical Sciences , Poznan , Poland.

Hypercortisolemia in females may lead to menstrual cycle disturbances, infertility, hirsutism and acne. Herewith, we present a 18-year-old patient, who was diagnosed due to weight gain, secondary amenorrhea, slowly progressing hirsutism, acne and hot flashes. Thorough diagnostics lead to a conclusion, that the symptoms was the first manifestation of primary pigmented nodular adrenocortical disease (PPNAD). Read More

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August 2018
2 Reads

A randomized, controlled trial comparing the metformin, oral contraceptive pills and their combination in patients with polycystic ovarian syndrome.

J Family Med Prim Care 2018 May-Jun;7(3):551-556

Department of Endocrinology, Army Hospital (R&R), New Delhi, India.

Background: Polycystic ovarian syndrome (PCOS) is a condition characterized by insulin resistance (IR) and hormonal dysfunction. We conducted a randomized, controlled trial comparing the effects of metformin, oral contraceptive pills (OCP) and their combination in PCOS.

Materials And Methods: We randomized 90 newly diagnosed PCOS (age 18-40 year, symptom duration >6 months) patients into three groups (Group 1-Metformin, Group 2-OCP, and Group 3- Metformin + OCP) in this prospective study. Read More

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August 2018
6 Reads

Polycystic Ovary Syndrome.

Authors:
Renate K Meier

Nurs Clin North Am 2018 Sep 11;53(3):407-420. Epub 2018 Jul 11.

Department of Obstetrics and Gynecology, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA. Electronic address:

Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. Traditionally, the treatment of patients with PCOS has focused on relief of symptoms. Read More

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September 2018
4 Reads

Correlating Impairment of Quality of Life and Severity of Melasma: A Cross-sectional Study of 141 Patients.

Indian J Dermatol 2018 Jul-Aug;63(4):292-296

Department of Dermatology, Dr. D. Y. Patil Medical College and Hospital, Pune, Maharashtra, India.

Background: The relationship between impaired quality of life (QoL) due to melasma and its clinical severity remains equivocal despite several studies.

Aim: The aim was to study the correlation, if any, between the clinical severity and the impairment in QOL due to melasma.

Methods: This cross-sectional, questionnaire-based study was conducted on a cohort of 141 patients of melasma attending the outpatient department of our referral hospital. Read More

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August 2018
4 Reads

A novel homozygous gene mutation: Aromatase deficiency mimicking congenital adrenal hyperplasia in an infant without obvious maternal virilisation.

J Clin Res Pediatr Endocrinol 2018 08 3. Epub 2018 Aug 3.

Department of Pediatric Endocrinology, SBU. Umraniye Training and Research Hospital, Istanbul, Turkey.

Aromatase deficiency is a rare autosomal recessive disorder in which affected patients cannot have a normal estrogen synthesis. Herein, we report a 46, XX patient born with virilised external genitalia. A novel homozygous mutation in the gene, causing aromatase deficiency, was detected. Read More

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August 2018
3 Reads

Mucopolysaccharidosis III in Taiwan: Natural history, clinical and molecular characteristics of 28 patients diagnosed during a 21-year period.

Am J Med Genet A 2018 Sep 2;176(9):1799-1809. Epub 2018 Aug 2.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Mucopolysaccharidosis type III (MPS III, Sanfilippo syndrome) has a variable age of onset and variable rate of progression. However, information regarding the natural history of this disorder in Asian populations is limited. A retrospective analysis was carried out for 28 patients with MPS III (types IIIA [n = 3], IIIB [n = 23], and IIIC [n = 2]; 15 males and 13 females; median age, 8. Read More

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September 2018
7 Reads

Florid hyperandrogenism due to a benign adrenocortical adenoma.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Endocrinologist, Centre of Endocrinology Diabetes & Metabolism, Limassol, Cyprus.

A 26-year-old woman with a history of polycystic ovarian syndrome presented with secondary amenorrhea, worsening hirsutism, acne, deepening of voice and unexplained 10-20 kg weight gain. Her Ferriman-Gallway hirsutism score was 12 with cystic facial acne and increased masculine phenotype. Urine Beta-Human Chorionic Gonadotropins (bHCG) was negative. Read More

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July 2018
3 Reads

Understanding variation in prevalence estimates of polycystic ovary syndrome: a systematic review and meta-analysis.

Hum Reprod Update 2018 Nov;24(6):694-709

Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Victoria, Australia.

Background: Polycystic ovary syndrome (PCOS) prevalence estimates vary when different diagnostic criteria are applied. Lack of standardization of individual elements within these criteria may contribute to prevalence differences.

Objective And Rationale: A systematic review of studies reporting prevalence of PCOS, using at least one of the National Institutes of Health (NIH), Rotterdam or Androgen Excess Society (AE-PCOS) criteria, was conducted. Read More

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November 2018
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Hormonal and metabolic aspects of acne vulgaris in women with polycystic ovary syndrome.

Eur Rev Med Pharmacol Sci 2018 Jul;22(14):4411-4418

Department of Endocrinological Gynecology, Medical University of Silesia, Katowice, Poland.

Objective: Acne vulgaris in women can indicate a systemic disease, such as polycystic ovary syndrome (PCOS), which is associated with hormonal and metabolic disorders. The aim of this study was to investigate the influence of hormonal and metabolic disorders on acne vulgaris in women with PCOS.

Patients And Methods: The study included 110 women with PCOS. Read More

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July 2018
2 Reads