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    Combined ovarian and adrenal venous sampling in the localization of ACTH-independent ectopic Cushing's syndrome.
    J Clin Endocrinol Metab 2017 Nov 16. Epub 2017 Nov 16.
    Department of Endocrinology, Endocrine Key Laboratory of Ministry of Health, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.
    Context: Cushing's syndrome is rarely caused by the secretion of cortisol from the ovarian tumors. It is important to determine whether the ovarian tumor is capable of secreting cortisol or not in clinical decision making. Selective ovarian and adrenal venous sampling has not been reported previously in the localization of ACTH-independent ectopic Cushing's syndrome. Read More

    An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence.
    Horm Res Paediatr 2017 Nov 13;Vol.(6):307-331. Epub 2017 Nov 13.
    Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania, USA.
    This paper represents an international collaboration of paediatric endocrine and other societies (listed in the Appendix) under the International Consortium of Paediatric Endocrinology (ICPE) aiming to improve worldwide care of adolescent girls with polycystic ovary syndrome (PCOS)1. The manuscript examines pathophysiology and guidelines for the diagnosis and management of PCOS during adolescence. The complex pathophysiology of PCOS involves the interaction of genetic and epigenetic changes, primary ovarian abnormalities, neuroendocrine alterations, and endocrine and metabolic modifiers such as anti-Müllerian hormone, hyperinsulinemia, insulin resistance, adiposity, and adiponectin levels. Read More

    [Treatments of steroid-dependent nephrotic syndrome in children].
    Arch Pediatr 2017 Nov 13. Epub 2017 Nov 13.
    Service de néphrologie pédiatrique, centre de référence du syndrome néphrotique idiopathique, institut Imagine, université Paris Descartes, hôpital Necker-Enfants-Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France.
    Primary nephrotic syndrome (NS) is the most common glomerular disease in children. It is characterized by massive proteinuria and hypoalbuminemia. It typically has a sudden onset and more than 70% of patients will experience at least one relapse. Read More

    Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study.
    Epilepsy Res 2017 Oct 28;139:20-27. Epub 2017 Oct 28.
    Department of Pharmacology, M.M. Institute of Medical Sciences and Research, M.M. University, Ambala, India.
    Objective: To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy.

    Methods: Reproductive hormonal profiles, hirsutism, ovarian morphology by ultrasonography and menstrual cycle data in newly diagnosed women with epilepsy taking VPA (n=34) or LTG (n=32) monotherapy were compared. None of the women were receiving hormonal contraception. Read More

    Postoperative Complications of Dermis-Fat Autografts in the Anophthalmic Socket.
    Semin Ophthalmol 2017 Nov 16:1-4. Epub 2017 Nov 16.
    a Ophthalmic Plastic Surgery Service, Department of Ophthalmology , Massachusetts Eye and Ear, Harvard Medical School , Boston , MA, USA.
    Reconstruction of the anophthalmic socket allows the use of an ocular prosthesis and rehabilitation of facial appearance. Dermis-fat grafting is one option in volume augmentation of the anophthalmic socket and presents unique benefits, including increased surface area within the socket and the ability to grow with pediatric patients. Postoperative complications of this procedure are relatively common. Read More

    Ovarian surgery for symptom relief in women with polycystic ovary syndrome.
    Cochrane Database Syst Rev 2017 Nov 10;11:CD009526. Epub 2017 Nov 10.
    Department of Obstetrics and Gynaecology, Capital and Coast District Health Board, Wellington, New Zealand.
    Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition, affecting approximately one in 10 women. PCOS is defined by two of three features: oligo- or anovulation, clinical or biochemical hyperandrogenism or both, or polycystic ovaries.Women with PCOS can have a wide range of health problems, including infrequent and irregular periods, unwanted hair growth and acne, and subnormal fertility. Read More

    Outcomes of oral lichen planus and oral lichenoid lesions treated with topical corticosteroid.
    Oral Dis 2017 Nov 9. Epub 2017 Nov 9.
    School of Dentistry. Instituto de Biomedicina de Granada, University of Granada, Spain.
    Objective: To determine corticosteroid treatment effectiveness in patients with Oral Lichen Planus/Oral Lichenoid Lesions (OLP/OLL).

    Material And Methods: Twenty-one OLP and eighty-one OLL patients received 0.05% clobetasol propionate (CP) or 0. Read More

    Very low dose of flutamide in the treatment of hyperandrogenism.
    Gynecol Endocrinol 2017 Nov 6:1-5. Epub 2017 Nov 6.
    a Department of Obstetric and Gynecology , Univ di Cagliari , Cagliari , Italy.
    Hyperandrogenism is a condition affecting 5-10% of adolescents. The aim of this study was to evaluate the efficacy of very low dose of flutamide in the treatment of hyperandrogenism in adolescence. One hundred and fifty-eight patients, presenting severe acne and/or hirsutism, received 62. Read More

    Homozygous Mutation in ELMO2 may cause Ramon syndrome.
    Clin Genet 2017 Nov 2. Epub 2017 Nov 2.
    Institut Jérôme Lejeune, Paris, France.
    We report on a girl, born to first cousin Lebanese parents, with intellectual disability, seizures, repeated gingivorrhagia, enlarged lower and upper jaws, overgrowth of the gums, high arched and narrow palate, crowded teeth, hirsutism of the back, large abdomen and a small umbilical hernia. Cysts of the mandible, fibrous dysplasia of bones, and enlarged adenoids causing around 60% narrowing of the nasopharyngeal airways were noted at radiographic examination. Her brother presented with the same features in addition to a short stature, an ostium secundum, and more pronounced intellectual disability. Read More

    Can laser treatment improve quality of life of hirsute women?
    Int J Womens Health 2017 19;9:777-780. Epub 2017 Oct 19.
    Dermatology Department, School of Medicine, Guilan University of Medical Sciences.
    Background: Hirsutism can have negative impacts on psychosocial aspects of women's lives and reduce their quality of life (QOL). The aim of this study was to assess the QOL of these women during laser treatment.

    Patients And Methods: Eighty-eight women with unwanted facial hair underwent laser therapy. Read More

    No. 350-Hirsutism: Evaluation and Treatment.
    J Obstet Gynaecol Can 2017 Nov;39(11):1054-1068
    Ottawa, ON.
    Objectives: To review the etiology, evaluation, and treatment of hirsutism.

    Evaluation: A thorough history and physical examination plus selected laboratory evaluations will confirm the diagnosis and direct treatment.

    Treatment: Pharmacologic interventions can suppress ovarian or adrenal androgen production and block androgen receptors in the hair follicle. Read More

    The impact of combined oral contraceptives on ocular tissues: a review of ocular effects.
    Int J Ophthalmol 2017 18;10(10):1604-1610. Epub 2017 Oct 18.
    Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, Greece.
    The aim of this manuscript is to review the action and adverse effects of combined oral contraceptives (COCs) on ocular tissues. The percentage of unwanted pregnancies and the subsequent abortions make contraception crucial worldwide. Over 100 million women around the world use common contraceptive methods, including intrauterine devices, combined estrogen and progestin oral contraceptives, as well as progestin only preparations (oral contraceptives, implants or injections). Read More

    Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life.
    FASEB J 2017 Oct 18. Epub 2017 Oct 18.
    Centre for Skin Sciences, University of Bradford, Bradford, United Kingdom;
    Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus hairs with larger, darker terminal hairs (e. Read More

    Testosterone Pellet Associated Dermatitis: Report and Review of Testopel-related Cutaneous Adverse Effects.
    Cureus 2017 Aug 11;9(8):e1560. Epub 2017 Aug 11.
    Department of Dermatology, University of California, San Diego.
    Testosterone replacement therapy is a treatment utilized for male hypogonadism. A subcutaneous testosterone pellet is a long-acting, slow-release delivery system that can be utilized as androgen replacement therapy. A 77-year-old man who was treated with testosterone pellets developed dermatitis consisting of erythematous plaques and patches on both buttocks and thighs within 28 days following the subcutaneous insertion of testosterone pellets. Read More

    Laser-Assisted Hair Removal for Facial Hirsutism in Women: A Review of Evidence.
    J Cosmet Laser Ther 2017 Oct 11. Epub 2017 Oct 11.
    a Department of Dermatology , Frimley Park hospital NHS Foundation Trust , Camberley , UK.
    Poly cystic ovarian syndrome (PCOS) has been described as the common diagnosis for hirsutism in women. Facial hirsutism is by far the most distressing symptom of hyperandrogenism in women with PCOS. A statistically significant improvement in psychological well-being has been reported in patients with PCOS allocated for laser-assisted hair removal. Read More

    Ornithine Decarboxylase Inhibition: A strategy to combat various diseases.
    Mini Rev Med Chem 2017 Sep 27. Epub 2017 Sep 27.
    Vivekanand Education Society`s College Of Pharmacy - Department of Pharmaceutical Chemistry Mumbai, Maharashtra. India.
    Ornithine decarboxylase is the first enzyme in the polyamine biosynthetic pathway. It is the rate-limiting enzyme which is included in the change of ornithine to putrescine which is the first polyamine. Polyamines (putrescine, spermidine, spermine) are natural and synthetic compounds which contains two or more amino group. Read More

    Higher prevalence of clinical cardiovascular comorbidities in postmenopausal women with self-reported premenopausal hirsutism and/or oligo-amenorrhea.
    Dermatoendocrinol 2017 22;9(1):e1356517. Epub 2017 Aug 22.
    Department of Clinical Medicine, Federal University of Santa Maria (UFSM), Santa Maria, Brazil.
    Hirsutism is a common condition, being present in about 5-15% of women. It is characterized by the growth of terminal hair in a pattern typical for men, like as hair growth in upper lip, chin, cheek and lower and upper abdomen. Not infrequently, hirsutism is followed by other signs of hyerandrogenism such as alopecia, acne, and seborrhea. Read More

    Clinical and hormonal features of women with polycystic ovary syndrome living in rural and urban areas.
    Ann Agric Environ Med 2017 Sep 11;24(3):522-526. Epub 2017 May 11.
    Department of Gynecological Endocrinology, Poznan University of Medical Sciences, Poznan, Poland.
    Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among women at reproductive age, but its pathology remains unknown. From epidemiological studies it is known that endogenous, mainly genetic and exogenous, environmental factors are of importance.

    Objective: The aim of the study was to compare the phenotype of women diagnosed with PCOS from urban and rural areas of Poland. Read More

    Polycystic ovary syndrome throughout a woman's life.
    J Assist Reprod Genet 2017 Sep 27. Epub 2017 Sep 27.
    Fundación Jiménez Díaz, Madrid, Spain.
    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age. Read More

    The cardiometabolic effect of current management of polycystic ovary syndrome: strategies of prevention and treatment.
    Gynecol Endocrinol 2017 Sep 23:1-5. Epub 2017 Sep 23.
    a Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility , University of Zagreb, School of Medicine, Clinical Hospital Centre Zagreb , Zagreb , Croatia.
    Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Read More

    Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China.
    J Cosmet Dermatol 2017 Sep 21. Epub 2017 Sep 21.
    Department of Dermatology, Xuan Wu Hospital Capital Medical University, Beijing, China.
    Background: Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers.

    Objectives: The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS. Read More

    Hypertensive crisis in pregnancy due to a metamorphosing pheochromocytoma with postdelivery Cushing's syndrome.
    Gynecol Endocrinol 2017 Sep 22:1-5. Epub 2017 Sep 22.
    a Institute of Clinical Chemistry and Laboratory Medicine , University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden , Dresden , Germany.
    Pheochromocytomas in pregnancy are rare but potentially lethal. Even rarer is the combination of pheochromocytoma in pregnancy with subsequent development of ectopic Cushing's syndrome. We report a 36-year-old woman, previously diagnosed with essential hypertension, who developed severe hypertension in pregnancy complicated by insulin-dependent gestational diabetes. Read More

    Marked hyperandrogenicity in a 60-year-old woman.
    Endocrinol Diabetes Metab Case Rep 2017 4;2017. Epub 2017 Sep 4.
    Department of Endocrinology, Royal College of Surgeons in Ireland, Connolly Hospital Blanchardstown, Dublin, Ireland.
    Markedly elevated androgen levels can lead to clinical virilization in females. Clinical features of virilization in a female patient, in association with biochemical hyperandrogenism, should prompt a search for an androgen-producing tumor, especially of ovarian or adrenal origin. We herein report the case of a 60-year-old woman of Pakistani origin who presented with the incidental finding of male pattern baldness and hirsutism. Read More

    Clinical and molecular characterization of two Chinese patients with Type 2 congenital generalized lipodystrophy.
    Gene 2017 Dec 12;637:57-62. Epub 2017 Sep 12.
    Department of Endocrinology, Fuzhou Children's Hospital of Fujian, Fujian Medical University Teaching Hospital, Fuzhou 350005, China.
    Background: Type 2 congenital generalized lipodystrophy (CGL2, OMIM 269700) is a rare autosomal recessive disease, characterized by the generalized absence of adipose tissue at birth or in early infancy. Pathogenic variants in BSCL2 gene have been reported to be responsible for CGL2. The aim of this study is to analyze the clinical and genetic characteristics of two Chinese patients with CGL2, and with particular focus on the BSCL2 gene sequence variants. Read More

    Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats.
    J Ovarian Res 2017 Sep 15;10(1):62. Epub 2017 Sep 15.
    Department of biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.
    Background: PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance.

    Methods: PCOs in Adult female rat was induced by the daily gastric administration of letrozole (1 mg/kg/day) in CMC (0. Read More

    Combined oral contraceptives plus spironolactone compared with metformin in women with polycystic ovary syndrome: a one-year randomized clinical trial.
    Eur J Endocrinol 2017 Nov;177(5):399-408
    DiabetesObesity and Human Reproduction Research Group, Department of Endocrinology & Nutrition, Hospital Universitario Ramón y Cajal & Universidad de Alcalá & Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Madrid, Spain
    Objective: We aimed to compare a combined oral contraceptive (COC) plus the antiandrogen spironolactone with the insulin sensitizer metformin in women with polycystic ovary syndrome (PCOS).

    Design: We conducted a randomized, parallel, open-label, clinical trial comparing COC (30 μg of ethinylestradiol and 150 μg of desogestrel) plus spironolactone (100 mg/day) with metformin (850 mg b.i. Read More

    Accessory ovarian steroid cell tumor producing testosterone and cortisol: A case report.
    Medicine (Baltimore) 2017 Sep;96(37):e7998
    aDepartment of Endocrinology bDepartment of Gynecology cDepartment of Pathology, Chinese PLA General Hospital, Beijing, China.
    Rationale: An accessory ovary is a rare structure containing normal ovarian tissue, which has a direct or ligamentous connection with a normal and eutopic ovary.

    Patient Concerns: In the study, we reported a 46-year-old woman presented with secondary amenorrhea and virilization symptoms for 1 year.

    Diagnoses: Endocrine evaluation revealed slightly elevated serum cortisol, extremely elevated 24-hour urinary-free cortisol and serum testosterone. Read More

    Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report.
    J Med Case Rep 2017 Aug 30;11(1):242. Epub 2017 Aug 30.
    Department of Obstetrics and Gynecology, University of Gondar, Gondar, Ethiopia.
    Background: Among classes of ovarian tumor, granulosa cell tumors are the least common. In approximately 10% of cases of granulosa cell tumor, androgen will be secreted which will present with hirsutism and hyperandrogenemia. We describe a woman with ovarian granulosa cell tumor who presented with hirsutism. Read More

    Therapeutic approach for metabolic disorders and infertility in women with PCOS.
    Gynecol Endocrinol 2017 Aug 29:1-6. Epub 2017 Aug 29.
    a Obstetrics and Gynecology, Department of Molecular and Developmental Medicine , University of Siena , Siena , Italy.
    Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5-10% of women of reproductive age. It generally shows with oligo/amenorrhea, anovulatory cycles, clinical o biochemical hirsutism, polycystic ovaries and, in a significant percentage of cases, insulin resistance. PCOS is defined as a multifactorial pathology, determined by the association of many factors: genetic, endocrine and environmental. Read More

    Polycystic ovary syndrome, personality, and depression: A twin study.
    Psychoneuroendocrinology 2017 Nov 10;85:63-68. Epub 2017 Aug 10.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, 171 77, Stockholm, Sweden; Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, 413 45, Gothenburg, Sweden.
    Background: Women with polycystic ovary syndrome (PCOS) are at elevated risk for suffering from depression. Neuroticism is a personality trait that has been associated with an increased risk for developing major depressive disorder (MDD). The aim of the present study was to quantify and decompose the correlation between neuroticism, PCOS, and MDD into shared and unique genetic and environmental etiologies, by using quantitative genetic methods. Read More

    A syndromic extreme insulin resistance caused by biallelic POC1A mutations in exon 10.
    Eur J Endocrinol 2017 Nov 17;177(5):K21-K27. Epub 2017 Aug 17.
    Department of Medical SciencesUniversity of Torino, Torino, Italy
    POC1A encodes a protein with a role in centriole assembly and stability, and in ciliogenesis. Biallelic loss-of-function mutations affecting POC1A cause SOFT syndrome, an ultra-rare condition characterized by short stature, onychodysplasia, facial dysmorphism and hypotrichosis. Using exome sequencing, we identified a homozygous frameshift mutation (c. Read More

    Laser and Light Treatments for Hair Reduction in Fitzpatrick Skin Types IV-VI: A Comprehensive Review of the Literature.
    Am J Clin Dermatol 2017 Aug 8. Epub 2017 Aug 8.
    Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, 1475 NW 12th Ave. Suite 2175, Miami, FL, 33136, USA.
    Unwanted facial and body hair presents as a common finding in many patients, such as females with hirsutism. With advances in laser and light technology, a clinically significant reduction in hair can be achieved in patients with light skin. However, in patients with darker skin, Fitzpatrick skin types (FST) IV-VI, the higher melanin content of the skin interferes with the proposed mechanism of laser-induced selective photothermolysis, which is to target the melanin in the hair follicle to cause permanent destruction of hair bulge stem cells. Read More

    Metabolic syndrome in Iranian adolescents with polycystic ovary syndrome.
    Int J Adolesc Med Health 2017 Aug 5. Epub 2017 Aug 5.
    Background Metabolic syndrome (MS) in adolescents is a risk factor for type 2 diabetes and cardiovascular diseases. Objective The present study aimed to determine the prevalence of MS in 14-18-year-old girls. Methods This analytical case-control study was conducted on 3200 high school students with polycystic ovarian syndrome (PCOS). Read More

    Modified Ferriman-Gallwey Score in Hirsutism and its Association with Metabolic Syndrome.
    Int J Trichology 2017 Jan-Mar;9(1):7-13
    Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.
    Background: Hirsutism is the presence of terminal hair in females in males pattern. It occurs in 5%-15% of women. Modified Ferriman-Gallwey (mFG) score of ≥ 8 is considered hirsutism, but there are populations with a low mFG score. Read More

    Progesterone receptor modulators for endometriosis.
    Cochrane Database Syst Rev 2017 Jul 25;7:CD009881. Epub 2017 Jul 25.
    Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
    Background: Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. Read More

    [Hirsutism - etiopathogenesis, diagnostics and treatment].
    Cas Lek Cesk 2017 ;156(3):133-136
    Hirsutism is defined as excessive terminal hair growth in distribution typical for postpubertal men. It affects approximately 5-10 % of women and most frequently manifests in puberty. Significant cosmetic stigmatization is the usual complaint that brings patient to the doctor and it is crucial to always rule out any primary underlying disease causing hirsutism - benign or malignant. Read More

    Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia.
    Horm Res Paediatr 2017 14;88(5):316-323. Epub 2017 Jul 14.
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
    Background: Diazoxide is the first-line treatment for pediatric hyperinsulinemic hypoglycemia (HI). This study aimed to elucidate the pharmacokinetics of diazoxide in children with HI.

    Methods: We obtained 81 blood samples from 22 children with HI. Read More

    Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
    J Adolesc Health 2017 Oct 14;61(4):446-453. Epub 2017 Jul 14.
    Pediatric & Adolescent Endocrinology, Department of Development & Regeneration, University Hospital Gasthuisberg-University of Leuven, Leuven, Belgium.
    Purpose: Polycystic ovary syndrome (PCOS) is an increasingly prevalent disorder in adolescent girls, commonly presenting with hirsutism/oligomenorrhea, commonly treated with an oral contraceptive (OC), and commonly followed by oligoanovulatory subfertility. We tested whether an intervention targeting the reduction of hepato-visceral adiposity is followed by a higher ovulation rate than OC treatment.

    Methods: This randomized, open-label, single-center, pilot proof-of-concept study (12 months on treatment, then 12 months off) was performed in adolescent girls with hirsutism and oligomenorrhea (PCOS by National Institutes of Health; no sexual activity; N = 36; mean age 16 years, body mass index 23. Read More

    Do anabolic-androgenic steroids have performance-enhancing effects in female athletes?
    Mol Cell Endocrinol 2017 Jul 12. Epub 2017 Jul 12.
    Section of Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
    Doping with anabolic-androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from clinical trials of testosterone administration in non-athlete women suggests that AAS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported. Read More

    Comparison of metformin and N-acetyl cysteine, as an adjuvant to clomiphene citrate, in clomiphene-resistant women with polycystic ovary syndrome.
    J Gynecol Obstet Hum Reprod 2017 Sep 8;46(7):579-585. Epub 2017 Jul 8.
    Female Fertility Clinic, Infertility Research Center of Hazrat-e Zahra, Shahrekord University of Medical Science, Shahrekord, Iran.
    Objective: To evaluate the effects of short- and long-term treatment with metformin and NAC, in an adjuvant to clomiphene citrate (CC), on the improvement of hormonal profile (SHBG, total testosterone, FBS, and fasting insulin) and fertility status in CC-resistant women with PCOS.

    Materials And Methods: One hundred and eight CC-resistant PCOS patients participated in the study and received either metformin (1500mg/day) or NAC (1800mg/day) with 100mg/day of CC for 8 and 12 weeks. Mean BMI, hirsutism score, LH/FSH ratio, endometrial thickness, mature follicle number, and serum concentrations of LH, FSH, E2, fasting insulin, total testosterone and FBS were evaluated before and after short- and long-term treatment. Read More

    Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height.
    J Pediatr Endocrinol Metab 2017 Jun 23. Epub 2017 Jun 23.
    Background: The clinical, laboratory, genetic properties and final height of a large cohort of patients with nonclassical 21-hydroxylase deficiency (NC21OHD) in Turkey were analyzed.

    Methods: This multicenter, nationwide web-based study collected data.

    Results: The mean age was 9. Read More

    In utero virilization secondary to a maternal Krukenberg tumor: case report and review of literature.
    J Pediatr Endocrinol Metab 2017 Jul;30(7):785-790
    Background: Krukenberg tumors are ovarian metastatic adenocarcinomas with a primary origin usually located in the stomach, colon, gallbladder, pancreas, or breast. Occasionally, these tumors produce virilization in the affected individual due to androgen production by luteinization of the tumoral stroma. It is believed that during pregnancy these tumors are more likely to increase androgen production due to the elevated levels of human chorionic gonadotropin (hCG). Read More

    The effect of cutaneous prostaglandin application on nail growth, nail brittleness, and intraocular pressure.
    J Cosmet Dermatol 2017 Jul 6. Epub 2017 Jul 6.
    University of Illinois at Urbana-Champaign, Urbana, IL, USA.
    Background: Bimatoprost has known adnexal activity and was observed to increase nail growth at two clinical centers.

    Objectives: In this randomized, double-blinded, placebo-controlled pilot study, we examine the effect of bimatoprost (Lumigan 0.01%), applied bid to the proximal nail fold on nail growth, nail brittleness, and intraocular pressure. Read More

    Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height.
    J Pediatr Endocrinol Metab 2017 Jul;30(7):759-766
    Background: The clinical, laboratory, genetic properties and final height of a large cohort of patients with nonclassical 21-hydroxylase deficiency (NC21OHD) in Turkey were analyzed.

    Methods: This multicenter, nationwide web-based study collected data.

    Results: The mean age was 9. Read More

    Subclinical hypothyroidism does not influence the metabolic and hormonal profile of women with PCOS.
    Horm Mol Biol Clin Investig 2017 Jun 23;31(3). Epub 2017 Jun 23.
    Background Subclinical hypothyroidism (SCH) is present in 5%-10% of polycystic ovary syndrome (PCOS) patients. To date, its impact on the metabolic and hormonal profile of those women remains controversial. The purpose of our study is to evaluate the impact of SCH on the glycemic, lipid and hormonal profile of PCOS patients. Read More

    Magnesium-Zinc-Calcium-Vitamin D Co-supplementation Improves Hormonal Profiles, Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial.
    Biol Trace Elem Res 2017 Jul 1. Epub 2017 Jul 1.
    Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
    Data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress among women with polycystic ovary syndrome (PCOS) are scarce. The objective of this study was to assess the effects of magnesium-zinc-calcium-vitamin D co-supplementation on hormonal profiles, biomarkers of inflammation, and oxidative stress in women with PCOS. Sixty PCOS women were randomized into two groups and treated with 100 mg magnesium, 4 mg zinc, 400 mg calcium plus 200 IU vitamin D supplements (n = 30), or placebo (n = 30) twice a day for 12 weeks. Read More

    Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome.
    Clin Chim Acta 2017 Aug 15;471:243-247. Epub 2017 Jun 15.
    The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou, China; Department of Pathology and Pathophysiology, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:
    Background: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients.

    Methods: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study. Read More

    Familial partial lipodystrophy and proteinuric renal disease due to a missense c.1045C > T LMNA mutation.
    Endocrinol Diabetes Metab Case Rep 2017 2;2017. Epub 2017 Jun 2.
    Departments of Endocrinology.
    Proteinuric renal disease is prevalent in congenital or acquired forms of generalized lipodystrophy. In contrast, an association between familial partial lipodystrophy (FPLD) and renal disease has been documented in very few cases. A 22-year-old female patient presented with impaired glucose tolerance, hyperinsulinemia, hirsutism and oligomenorrhea. Read More

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