Search Our Scientific Publications & Authors

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211056494

Dignity Health, Phoenix, AZ, USA.

Androgen-producing steroid cell ovarian tumors are rare, comprising less than 1% of ovarian neoplasms, and can present with infertility and rapid virilization. Here we discuss the case of a 28-year-old woman who presented with an unusually insidious 2-year history of infertility, hirsutism, and clitoromegaly who was found to have an elevated serum testosterone and a left ovarian mass. She underwent oophorectomy and pathology revealed a steroid cell tumor, not otherwise specified (NOS), with no malignant features. Read More

Aten Primaria 2022 May 12;54(6):102354. Epub 2022 May 12.

Health Research Group GIIS100 of Health Research Institute IIS Aragón, Zaragoza, España; Servicio de Dermatología y Venereología, Hospital Clínico Universitario Miguel Servet, Zaragoza, España.

Objetive: To review and discuss the current evidence of the use of metformin as a therapeutic tool in frequent skin diseases.

Design: Original article. Qualitative research. Read More

BMC Womens Health 2022 May 13;22(1):165. Epub 2022 May 13.

Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, 56219, Saudi Arabia.

Background: Polycystic ovary syndrome (PCOS) is a global health problem associated with significant morbidity during reproductive age. Only a few published studies that address the clinical manifestations and phenotypic presentation of the disease have been conducted in Africa, including Sudan. Thus, this study aimed to evaluate the clinical and biochemical presentation of the different PCOS phenotypes among infertile Sudanese women. Read More

J Affect Disord 2022 May 11;310:296-303. Epub 2022 May 11.

Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong, China.

Background: The manifestations of Polycystic Ovary Syndrome (PCOS), including acne, hirsutism, obesity, uncertain fertility, etc., can make women anxious, worried, or even depressed with their appearance and body. However, little relevant research has been conducted in the Chinese context. Read More

Endocr Metab Immune Disord Drug Targets 2022 May 9. Epub 2022 May 9.

Endocrinology Unit, Department of Medicine, University of Padova, Padova, Italy.

Objective: Hyperandrogenic skin disorders, such as hirsutism, acne and alopecia, affect approximately 10-20% of women of reproductive age, reducing quality of life and causing psychological impairment. Spironolactone is a commonly used antiandrogen, especially in women who are not sexually active or have contraindications to hormonal contraceptives. The aim of this study was to evaluate the effects of spironolactone, especially after its withdrawal, in patients with hyperandrogenic skin disorders. Read More

J Cosmet Dermatol 2022 May 9. Epub 2022 May 9.

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: This study aimed to evaluate the Standardized Mean Difference (SMD) of insulin resistance parameters in women with IH, compared to healthy and polycystic ovary syndrome (PCOS) controls.

Materials And Methods: PubMed, Scopus, Web of Sciences, and Embase were searched for retrieving studies published up to November 2021 investigating the insulin resistance parameters in women with IH, compared to control groups. Meta-regression and subgroup analysis were conducted to evaluate the effect of potential confounders, such as age, BMI, and study design. Read More

Int J Trichology 2022 Mar-Apr;14(2):71-72. Epub 2022 Apr 4.

Department of Endocrinology, Care Hospitals, Hyderabad, Telangana, India.

A sixty years postmenopausal lady presented with growing longer eyelashes for 8 years. She had thick, dark, curly eyelashes measuring 23 mm and 15 mm at the centre and periphery respectively suggesting marked trichomegaly. Increased vellus hair was noticed above lips and chin suggesting hypertrichosis. Read More

Diabetes Metab Syndr Obes 2022 24;15:1281-1291. Epub 2022 Apr 24.

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

Polycystic ovary syndrome (PCOS) is one of the most common reproductive, endocrine, and metabolic disorders in premenopausal women. Clinically, PCOS is mainly caused by androgen excess and ovarian dysfunction, manifested by anovulatory menstrual cycles, infertility, and hirsutism. In addition, PCOS increases the risk of insulin resistance, obesity, cardiovascular disease, anxiety and depression, dyslipidemia, and endometrial cancer. Read More

BJGP Open 2022 Apr 29. Epub 2022 Apr 29.

School of Psychology, University of Surrey, Guildford, Surrey, UK.

Background: Polycystic Ovary Syndrome (PCOS) is associated with well-being. Many women report dissatisfaction with the diagnostic process.

Aim: This study assessed the impact of aspects of the diagnostic consultation on subsequent well-being. Read More

J Pers Med 2022 Apr 6;12(4). Epub 2022 Apr 6.

Faculty of Applied Medical Science, University of Tabuk, Tabuk 71491, Saudi Arabia.

Polycystic ovary syndrome (PCOS) is a disorder with a symptomatic manifestation of an array of metabolic and endocrine impairments. PCOS has a relatively high prevalence rate among young women of reproductive age and is a risk factor for some severe metabolic diseases such as T2DM, insulin insensitivity, and obesity, while the most dominant endocrine malfunction is an excess of testosterone showing hyperandrogenism and hirsutism. MicroRNAs have been implicated as mediators of metabolic diseases including obesity and insulin resistance, as these can regulate multiple cellular pathways such as insulin signaling and adipogenesis. Read More

Clin Chim Acta 2022 Apr 18;531:265-272. Epub 2022 Apr 18.

Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital. Beijing 100026, China. Electronic address:

A polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting females. Furthermore, it is a heterogeneous disease with a variety of etiologies and outcomes. Patients frequently complain about infertility, irregular menstruation, acne, seborrheic dermatitis, hirsutism, and obesity. Read More

BMJ Case Rep 2022 Apr 20;15(4). Epub 2022 Apr 20.

Obstetrics and Gynaecology, Centro Hospitalar do Baixo Vouga EPE, Aveiro, Portugal.

Hyperandrogenism with virilisation de novo in postmenopausal women is exceedingly rare, with aetiology oscillating between ovarian tumours, adrenal tumours, ovarian hyperthecosis and, less frequently, Cushing's syndrome. We report a case of a postmenopausal woman in her late 60s, referred from her primary healthcare physician to a gynaecology appointment due to hirsutism and vasomotor symptoms. At physical examination, clitoromegaly was also identified. Read More

FP Essent 2022 04;515:26-31

Department of Family Medicine - University of California San Diego School of Medicine, 402 Dickinson St, San Diego, CA 92103.

It is estimated that polycystic ovary syndrome (PCOS) affects about 10% of women of reproductive age in the United States. Principal risk factors include obesity and a family history of PCOS. A diagnosis of PCOS should be considered in women with irregular or absent menstrual cycles, issues related to hyperandrogenism, or infertility. Read More

Dermatol Ther 2022 Apr 13:e15509. Epub 2022 Apr 13.

Department of DVL, IMS & SUM Hospital, Bhubaneswar, Odisha, India.

Hirsutism is defined as an excessive terminal hair growth in female over male pattern distribution areas. Traditional methods of hair removal have been replaced by lasers. The aim of the study was to observe the effect of diode laser in hirsutism patient with normal and deranged dehydroepiandrosterone sulfate (DHEAS) and dihydrotestosterone (DHT) level. Read More

Am J Case Rep 2022 Apr 8;23:e936029. Epub 2022 Apr 8.

Department of Surgery, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

BACKGROUND Carcinoid tumors are well-differentiated tumors that develop from neuroendocrine cells. They are rare tumors and occur most commonly in the gastrointestinal tract, followed by the pulmonary system. They usually present with abdominal pain or cough or persistent pneumonia. Read More

Front Endocrinol (Lausanne) 2022 10;13:848947. Epub 2022 Mar 10.

Division of Bariatric and Metabolic Surgery, Department of General Surgery, Qilu Hospital of Shandong University, Jinan, China.

Polycystic ovary syndrome (PCOS) is a complicated reproductive endocrine disease that is closely related to obesity. Metabolic surgery ameliorates a series of clinical manifestations and related comorbidities of PCOS. However, the overall efficacy of metabolic surgery on PCOS remains uncertain. Read More

Indian J Endocrinol Metab 2021 Nov-Dec;25(6):551-558. Epub 2022 Feb 17.

Department of Molecular Genetics, Alpha Health Foundation, Madurai, Tamil Nadu, India.

Background: Polycystic ovarian syndrome (PCOS) is typically characterized by a spectrum of manifestations that include menstrual irregularities, anovulation, cysts, hyperandrogenic features like hirsutism, acne, alopecia, and various metabolic complications. The pathology of PCOS is complex and several mechanisms have been potentially involved in the genetic abnormalities/dysfunctions. Hence, the present study aims to examine the prevalence and association of polymorphisms in candidate genes (thyroid adenoma-associated gene [THADA], luteinizing hormone and human chorionic gonadotropin receptor [LHCGR], DENN domain containing 1A [DENND1A], follicle-stimulating hormone receptor [FSHR], Connexin37 [CX37], angiotensin-converting enzyme [ACE], insulin receptor [INSR] and calpain 10 [CAPN10]) in PCOS patients of the South Indian regional population. Read More

Arch Gynecol Obstet 2022 Mar 30. Epub 2022 Mar 30.

Department of Clinical Biochemistry, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.

Purpose: To determine the variation in anti-Mullerian hormone (AMH) and androstenedione (A4) concentrations in adolescent girls, with or without menstrual cycle disorder in relation to phenotypic features of. PCOS.

Methods: Adolescent girls (n = 129), age range 14-19 years, were recruited in the cohort study. Read More

Public Health Genomics 2022 Mar 29:1-9. Epub 2022 Mar 29.

Applied Medical Sciences, The Hashemite University, Zarqa, Jordan.

Background: Polycystic ovary syndrome (PCOS) is a common heterogeneous disorder characterized by chronic anovulation, infertility, polycystic ovaries, and hyperandrogenic signs.

Objective: The aim of this study was to determine the association of luteinizing hormone/chorionic gonadotropin hormone receptor LHCGR polymorphism (rs2293275) with oligomenorrhea, amenorrhea, hirsutism, acne, infertility, LH, LH/FSH ratio, and body mass index (BMI) among PCOS females.

Methods: This genetic case-control study recruited 55 PCOS and 55 control females, diagnosed based on the Rotterdam criteria. Read More

Clin Endocrinol (Oxf) 2022 Mar 29. Epub 2022 Mar 29.

Department of Medicine, Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Republic of Ireland.

Androgen excess in women typically presents clinically with hirsutism, acne or androgenic alopecia. In the vast majority of cases, the underlying aetiology is polycystic ovary syndrome (PCOS), a common chronic condition that affects up to 10% of all women. Identification of women with non-PCOS pathology within large cohorts of patients presenting with androgen excess represents a diagnostic challenge for the endocrinologist, and rare pathology including nonclassic congenital adrenal hyperplasia, severe insulin resistance syndromes, Cushing's disease or androgen-secreting tumours of the ovary or adrenal gland may be missed in the absence of a pragmatic screening approach. Read More

Ginekol Pol 2022 Mar 22. Epub 2022 Mar 22.

Gynecology Department, University Hospital Center of Coimbra (CHUC), Portugal, Portugal.

Objectives: Analysis of congenital adrenal hyperplasia (CAH) cases, gynaecological implications, referral reasons to gynaecologist and treatment.

Material And Methods: Retrospective, longitudinal, single-centre study with female CAH paediatric patients ≥ 10 years-old, followed between 1998-2018 in gynaecology and endocrinology departments at a public university tertiary hospital.

Results: 47 patients, 34. Read More

Clin Chim Acta 2022 Mar 12;531:17-24. Epub 2022 Mar 12.

Amsterdam UMC, Vrije Universiteit Amsterdam and University of Amsterdam, Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology Endocrinology & Metabolism, de Boelelaan 1117 and Meibergdreef 9, Amsterdam, the Netherlands. Electronic address:

Background: Hirsutism is the excessive growth of terminal hair in a male pattern in a female. In most hirsute women, hirsutism is caused by increased androgens. However, not all women with hirsutism actually show elevated levels of circulating androgens with standard laboratory tests, in which case we speak of idiopathic hirsutism (IH). Read More

JMIR Form Res 2022 Mar 15;6(3):e29967. Epub 2022 Mar 15.

Department of Mathematics and Statistics, University of Massachusetts Amherst, Newton, MA, United States.

Background: Artificial intelligence and digital health care have substantially advanced to improve and enhance medical diagnosis and treatment during the prolonged period of the COVID-19 global pandemic. In this study, we discuss the development of prediction models for the self-diagnosis of polycystic ovary syndrome (PCOS) using machine learning techniques.

Objective: We aim to develop self-diagnostic prediction models for PCOS in potential patients and clinical providers. Read More

Environ Toxicol Pharmacol 2022 May 11;92:103848. Epub 2022 Mar 11.

Department of Biology, Roanoke College, 221 College Lane, Salem, VA 24153, USA. Electronic address:

Spironolactone, a potassium-sparing diuretic and aldosterone antagonist, is a mineralocorticoid hormone commonly prescribed to patients suffering from heart failure, hirsutism, dermatological afflictions, and hypertension. Interestingly, relatively little work has been done on the development of vertebrate embryos after exposure to this compound. Here, we treat zebrafish embryos with spironolactone at 10 M, 10 M, or 10 M, and observe them after three to seven days of exposure. Read More

J Dermatol Sci 2022 Apr 28;106(1):21-28. Epub 2022 Feb 28.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Institute of Human-Environment Interface Biology, Medial Research Center, Seoul National University, Seoul, Republic of Korea, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; Genomic Medicine Institute (GMI), Medical Research Center, Seoul National University, Seoul, Republic of Korea; Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea. Electronic address:

Background: Female pattern hair loss (FPHL), the most common cause of alopecia in adult women, is classified into two subtypes: early onset and late onset (or postmenopausal). Little is known about the clinical features and genetic characteristics of early onset female pattern hair loss (eFPHL).

Objectives: To investigate the clinical features and genetic characteristics of eFPHL. Read More

JBRA Assist Reprod 2022 Mar 8. Epub 2022 Mar 8.

Department of Internal Medicine Shahid Beheshti Hospital Babol University of Medical Sciences Babol Iran Department of Internal Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran.

Polycystic ovary syndrome is the most common endocrine disorder in women. Today, medicinal plants have been considered by women, especially in the reproductive and pregnancy ages. Multiple drug treatments and the length of the treatment period often lead to incomplete treatment by patients. Read More

J Cosmet Dermatol 2022 Mar 7. Epub 2022 Mar 7.

Health Metrics Research Center, Iranian Institute for Health Sciences Research, ACECR, Tehran, Iran.

Background And Objectives: Hirsutism is associated with other androgen-dependent signs/symptoms. This study was designed with the aim of a comprehensive investigation of laboratory and ultrasonographic findings in hirsute women and their probable association with the "severity" of the disease.

Patients And Methods: This cross-sectional study included 123 hirsute women. Read More

Hum Reprod Update 2022 Mar 3. Epub 2022 Mar 3.

Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Background: An increased prevalence of functional hyperandrogenism-including polycystic ovary syndrome (PCOS)-has been described in women with type 1 diabetes (T1D). However, heterogeneity between studies is frequent, and prevalence rates vary according to different criteria used for the diagnosis of PCOS and the population studied.

Objective And Rationale: We aimed to perform a systematic review and meta-analysis of the prevalence of PCOS and related hyperandrogenic traits in premenopausal women with T1D. Read More

Eur J Obstet Gynecol Reprod Biol 2022 Apr 17;271:189-194. Epub 2022 Feb 17.

From the Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

Objective: The goal of this research was to evaluate the Health-Related Quality of Life (HRQoL) of Chinese women with varying phenotypes of Polycystic Ovary Syndrome (PCOS) and related factors in order to guide clinical treatment.

Methods: We employed a cross-sectional design that included 221 women with an initial diagnosis of PCOS at the Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital. All subjects were stratified, according to the Rotterdam criteria, into three sub-cohorts: phenotype A (n = 100), phenotype B (n = 60), and phenotype D (n = 61). Read More

J Am Acad Dermatol 2022 Feb 24. Epub 2022 Feb 24.

Department of Dermatology, University of Iowa Carver College of Medicine, Iowa.