Search Our Scientific Publications & Authors

J Sport Rehabil 2020 Jun 5:1-5. Epub 2020 Jun 5.

Clinical Scenario: Many people with lower quarter musculoskeletal dysfunction present with muscle weakness. Strength training hypertrophies muscle and increases strength, but often requires periods over 6 weeks, which can exceed the episode of care. Weakness can persist despite muscle hypertrophy, particularly in the early stages of joint pathology or in the presence of limb or spinal joint hypomobility, which may inhibit muscle activation. Read More

Gait Posture 2020 May 22;80:106-112. Epub 2020 May 22.

Washington State University, 101 Physical Education Building, Pullman, WA, United States.

Background: Dynamic balance control degrades during pregnancy, but it is not yet understood why. Mechanical aspects of the body should directly affect walking balance control, but we have recently published papers indicating that weight gains during pregnancy explain very little dynamic balance changes. Our goal was to determine if lower extremity joint kinematic changes are an indicator of walking balance control. Read More

J Orthop Trauma 2020 Jun 1. Epub 2020 Jun 1.

Akdeniz University, Medical Faculty, Department of Anatomy, Antalya, TR.

Objectives: Complex acetabular fractures involving the quadrilateral plate may necessitate infrapectineal buttress plating, which can be performed through the pararectus approach. The aim of this cadaveric study was to identify the anatomical guide points to protect neurovascular structures at risk of injury during the pararectus approach.

Methods: Six fresh frozen cadavers (12 hemipelves) were dissected in this study. Read More

J Pediatr Orthop 2020 Jul;40(6):314-321

Departments of Orthopaedics and Rehabilitation.

Background: Musculoskeletal infection is a major cause of morbidity in the pediatric population. Despite the canonical teaching that an irritable joint and signs of infection likely represent an infected joint space, recent evidence in the pediatric hip has demonstrated that alternative diagnoses are equally or more likely and that combinations of pathologies are common. The knee is the second most commonly infected joint in children, yet there remains a paucity of available data regarding the epidemiology and workup of the infected pediatric knee. Read More

J Am Acad Orthop Surg 2020 Jun 2. Epub 2020 Jun 2.

From the Department of Orthopaedic Surgery (Dr. Hsiue, Dr. Greig, Mr. Chen, Mr. Patel, Dr. Trikha, Dr. Stavrakis), David Geffen School of Medicine at UCLA, Los Angeles, CA, Department of Trauma and Orthopaedic Surgery (Dr. Rowan), University Hospital Waterford, Ireland, and the Division of Orthopaedic Surgery (Dr. Khoshbin), University of Toronto, Toronto, ON, Canada.

Background: Acute colonic pseudo-obstruction (Ogilvie syndrome [OS]) is a rare but devastating condition that can develop in orthopaedic patients postoperatively. The objective of this study was to identify the risk factors for developing OS after total hip arthroplasty (THA) or total knee arthroplasty (TKA) and to compare the outcomes between patients who did and did not develop OS postoperatively.

Methods: This was a retrospective review using the National Inpatient Sample, a national database incorporating inpatient hospitalization information. Read More

Ann Plast Surg 2020 Jun 2. Epub 2020 Jun 2.

From the Department of Orthopedics.

Introduction: Nontraumatic osteonecrosis of the femoral head (NONFH) is a common and difficult disease in orthopedics. Magnetic resonance imaging (MRI) assessment of NONFH and bone marrow edema was combined with digital subtraction angiography (DSA) to evaluate the circulatory status of NONFH in different Association Research Circulation Osseous stages. Based on the circulatory obstruction status (venous stasis, arterial ischemia, and arterial occlusion), appropriate perioperative management was adopted to achieve hip joint preservation and effectively delay the time for total hip arthroplasty in young patients. Read More

Orthopedics 2020 Jun 4:1-7. Epub 2020 Jun 4.

Obesity affects one-third of total joint arthroplasty (TJA) patients and is the most common modifiable risk factor for increased complications in the TJA population. The authors' institution implemented a body mass index (BMI) cutoff of 40 kg/m to define appropriate TJA candidates. Patients above the cutoff were referred for nutritional counseling. Read More

Orthopedics 2020 Jun 4:1-8. Epub 2020 Jun 4.

The characteristics and clinical consequences of pyogenic bone and joint infections in older children and adolescents have received little attention. This study evaluated the presentation and complications of musculoskeletal infections involving the pelvis and extremities in children older than 10 years. Thirty patients 10 to 17 years old (mean, 12. Read More

J Aging Health 2020 Jun 5:898264320925259. Epub 2020 Jun 5.

University of Texas Medical Branch , Galveston, TX, USA.

To investigate the association between functional status and post-acute care (PAC) transition(s). Secondary analysis of 2013-2014 Medicare data for individuals aged ≥66 years with stroke, lower extremity joint replacements, and hip/femur fracture discharged to one of three PAC settings (inpatient rehabilitation facilities, skilled nursing facilities, and home health agencies). Functional scores were co-calibrated into a 0-100 scale across settings. Read More

Sports Biomech 2020 Jun 5:1-17. Epub 2020 Jun 5.

Division of Environmental Physiology, Swedish Aerospace Physiology Centre, School of Engineering Sciences in Chemistry, Biotechnology, and Health (CBH), KTH Royal Institute of Technology , Solna, Sweden.

Resistance exercise on Earth commonly involves both body weight and external load. When developing exercise routines and devices for use in space, the absence of body weight is not always adequately considered. This study compared musculoskeletal load distribution during two flywheel resistance knee-extension exercises, performed in the direction of (vertical squat; S) or perpendicular to (horizontal leg press; LP) the gravity vector. Read More

Scand J Surg 2020 Jun 5:1457496920930617. Epub 2020 Jun 5.

Department of Orthopaedics and Traumatology, Turku University Hospital, University of Turku, Turku, Finland.

Background And Aims: Dislocation is one of the most common reasons for revision surgery after primary total hip arthroplasty. Both patient related and surgical factors may influence the risk of dislocation. In this study, we evaluated risk factors for dislocation revision after total hip arthroplasty based on revised data contents of the Finnish Arthroplasty Register. Read More

Clin Rheumatol 2020 Jun 4. Epub 2020 Jun 4.

Department of Rehabilitation and Movement Sciences, Physical Therapy Program North, Rutgers, School of Health Professions, The State University of New Jersey, 65 Bergen Street - Office 714A, Newark, NJ, 07107, USA.

Although 25% of patients with end-stage knee osteoarthritis (OA) have reported a fall, there is limited information about risk factors for falling in patients awaiting total knee arthroplasty (TKA). The purpose of this study was to identify clinical and functional measures related to fall risk. A total of 259 participants awaiting TKA for OA participated in this secondary cross-sectional study. Read More

Biomed Opt Express 2020 May 27;11(5):2745-2760. Epub 2020 Apr 27.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6 T 1Z4, Canada.

Detecting articular cartilage (AC) degeneration in its early stage plays a critical role in the diagnosis and treatment of osteoarthritis (OA). Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to the alteration and disruption of collagen organization that happens during OA progression. This study proposes an effective OA evaluating method based on PS-OCT imaging. Read More

J Arthroplasty 2020 May 6. Epub 2020 May 6.

Department of Orthopaedic Surgery, University of California, San Francisco, CA; Orthopedic Surgery Section, San Francisco Veterans Affairs Health Care System, San Francisco, CA.

Background: Social determinants of health (SDOH) are the conditions in which people are born, grow, live, work, and age. They are associated with disparities in outcomes following total joint arthroplasty (TJA). These disparities occur even in equal-access healthcare systems such as the Veterans Health Administration (VHA). Read More

Zhonghua Wai Ke Za Zhi 2020 Jun;58(6):464-468

School of Public Health, Xinjiang Medical University, Urumqi 830011, China.

To investigate the diagnose value of D-dimer for chronic periprosthetic infection (PJI) after hip and knee arthroplasty. A retrospective analyze was conducted on 168 patients underwent revision arthroplasty and primary arthroplasty at the First Affiliated Hospital of Xinjiang Medical University from November 2017 to December 2018.There were 58 males and 110 females, aged(58. Read More

Zhonghua Wai Ke Za Zhi 2020 Jun;58(6):457-463

Center of Diagnosis and Treatment for Joint Disease, Beijing Charity Hospital, Capital Medical University, Beijing 100068, China.

To examine the clinical effects of the treatment of knee osteoarthritis patients with kinematic alignment technique of total knee replacement (KA-TKA) assisted by patient-specific instrumentation (PSI). The clinical data of 14 patients with knee osteoarthritis treated with unilateral KA-TKA assisted by PSI at Department of Orthopaedic Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University from May 2018 to August 2019 were analyzed retrospectively. There were 6 males and 8 females, aged 66. Read More

Sensors (Basel) 2020 Jun 2;20(11). Epub 2020 Jun 2.

Motion Analysis, Ergonomics, Biomechanics and Motor Control Laboratory (LAMBECOM), Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos, 28922 Madrid, Spain.

Gait analysis is necessary to diagnose movement disorders. In order to reduce the costs of three-dimensional motion capture systems, new low-cost methods of motion analysis have been developed. The purpose of this study was to evaluate the inter- and intra-rater reliability of Kinovea and the agreement with a three-dimensional motion system for detecting the joint angles of the hip, knee and ankle during the initial contact phase of walking. Read More

J Bone Joint Surg Am 2020 Jun;102(11):991-999

Dorr Institute for Arthritis Research and Education, Pasadena, California.

Background: The spine-pelvis-hip interaction during postural change should be considered in the functional anatomy of the hip. The component parts of this anatomy and how they influence hip function are important to know. Pelvic incidence (PI) is one of these components. Read More

J Bone Joint Surg Am 2020 Jun;102(11):e55

Division of Orthopedic Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Orthopade 2020 Jun 3. Epub 2020 Jun 3.

Orthopädische Klinik, Medizinische Hochschule Hannover im Annastift, Hannover, Deutschland.

Background: Despite the growing clinical evidence "pro" kinematic alignment (KA) in primary total knee arthroplasty, the idea of this individualized implant positioning has not (yet) become established throughout the community. Many surgeons have concerns about the safety of the method and the universality of its application. Interestingly, comparative studies with unlimited indications for KA showed only little or no advantage over standard mechanical alignment in contrast to studies with strict indications showing a significant benefit. Read More

J Orthop 2020 Jul-Aug;20:310-325. Epub 2020 May 19.

Bone and Joint Institute, University of Western Ontario, London, Ontario, Canada.

Background: Various surgical approaches exist for Total Hip Arthroplasty (THA), but approach specific complication rates remain unknown. The purpose of this systematic review and meta-analysis was to compare rates of common complications between surgical approaches.

Methods: Four electronic databases (Medline, Embase, AMED, Ovid Healthstar) were searched from inception to June 2019. Read More

J Orthop 2020 Jul-Aug;20:305-309. Epub 2020 Mar 26.

116 Nursery Ridge Lane, Columbia, SC, 29212, USA.

As the population ages and as people live longer, there is a growing demand for total hip and total knee procedures. Possible outcomes for these procedures is a postoperative joint infection (PJI) that can cause long postoperative lengths of stay (LOS) in the hospital. The PJIs can also negatively impact the quality of life for the patient. Read More

J Orthop Surg Res 2020 Jun 3;15(1):206. Epub 2020 Jun 3.

Department of Joint Surgery, Aviation General Hospital, Courtyard 3, AnwaiBeiyuan, Chaoyang District, Beijing, China.

Background: Osteonecrosis of the femoral head (ONFH) causes severe hip dysfunction. Left untreated, 80% of patients experience femoral head collapse, and 65-70% of patients require total hip arthroplasty (THA). Therefore, effective treatment is very important for ONFH. Read More

BMC Musculoskelet Disord 2020 Jun 3;21(1):345. Epub 2020 Jun 3.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery (CMSC), Charitéplatz 1, D-10117, Berlin, Germany.

Background: Synovial fluid culture is the standard investigation for the preoperative diagnosis of periprosthetic joint infection (PJI). However, the culture has limited sensitivity and requires several days until result. We evaluated the value of isothermal microcalorimetry for real-time diagnosis of PJI based on heat produced by microbial growth in synovial fluid. Read More

J Appl Biomech 2020 Jun 3:1-11. Epub 2020 Jun 3.

University of Illinois at Chicago.

Slip outcomes are categorized as either a backward loss of balance (LOB) or a no loss of balance (no-LOB) in which an individual does not take a backward step to regain their stability. LOB includes falls and nonfalls, while no-LOB includes skate overs and walkovers. Researchers are uncertain about which factors determine slip outcomes and at which critical instants they do so. Read More

Acta Orthop Belg 2020 Mar;86(1):54-63

We sought to characterize the causative pathogens of prosthetic joint infections (PJIs), evaluate the trends in microbial etiologies, and identify potential risk factors for PJI. This was a retrospective study analyzing 70 patients with PJI following 3,253 total joint arthroplasties between 2011 and 2017. Staphylococci were the most common cause of infection (52. Read More

Acta Orthop Belg 2020 Mar;86(1):10-16

Long-term evaluation of prosthetic joint infection treated with two-stage revision. Retrospective analysis of 102 periprosthetic infections treated with two-stage revision from 2010 to 2012 in Albenga hospital, Italy. During the second stage, samples for microbiological tests were collected. Read More

Scand J Med Sci Sports 2020 Jun 3. Epub 2020 Jun 3.

National Institute of Fitness and Sports in Kanoya, Kagoshima, Japan.

Limited information is available on whether stiffness is different within and between the constituents of the hamstring, i.e., the biceps femoris long head (BFlh), semitendinosus (ST), and semimembranosus (SM). Read More

J Orthop Translat 2020 Jul 8;23:53-60. Epub 2020 May 8.

Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopedics, Lund, Sweden.

Background: Prosthetic joint infection (PJI) is the most serious total joint arthroplasty (TJA) complication despite several aseptic and antiseptic preventive measures. There is no clear evidence or even consensus, whether antibiotic-loaded bone cement (ALBC) should be used, in addition to systemic short-term routine antibiotic prophylaxis, to reduce the risk of PJI in primary TJA. We aimed to analyze the efficacy of ALBC for prevention of PJI in patients undergoing primary TJA. Read More

Cureus 2020 Apr 28;12(4):e7867. Epub 2020 Apr 28.

Surgery, National and Kapodistrian University of Athens Medical School, Athens, GRC.

The deep femoral artery (DFA) is the largest branch of the common femoral artery (CFA), supplying with its branches, the medial circumflex femoral artery (MCFA) and lateral circumflex femoral artery (LCFA), the thigh muscles, the hip joint, and the femur. Their anatomical variations have a great impact on both interventional and surgical procedures. The anterolateral thigh (ALT) flap, a versatile soft tissue with highly increasing use in reconstructive surgery, is noticeably influenced by this variability. Read More

Arch Osteoporos 2020 Jun 2;15(1):83. Epub 2020 Jun 2.

University of Alberta (Medicine), Edmonton, AB, Canada.

A hip fracture liaison service that was implemented in 2 hospitals in Alberta, Canada, co-managed by a nurse and physician, was effective for improving initiation of osteoporosis medication following hip fracture.

Purpose: To examine implementation of an in-patient hip fracture liaison service (H-FLS) to improve osteoporosis medication use after hip fracture using the RE-AIM framework (reach, effectiveness, adoption, implementation, maintenance).

Methods: Using population-based administrative data from 7 quarters before and up to 7 quarters after H-FLS implementation, we examined new starts, continued use, and overall use (new starts + continued use) of osteoporosis medication after hip fracture. Read More

BMJ Case Rep 2020 Jun 1;13(6). Epub 2020 Jun 1.

Department of Orthopaedics, Army Hospital Research and Referral, New Delhi, Delhi, India.

Sjogren's syndrome (SS) is a chronic, autoimmune, inflammatory disorder affecting primarily the salivary and lacrimal glands with potential for systemic involvement. The disease predominantly occurs in women in the age group of 35-45 years and is relatively rare in children. It mainly affects salivary and lacrimal glands with potential for systemic involvement. Read More

J Arthroplasty 2020 May 11. Epub 2020 May 11.

Joint Implant Surgeons, Inc., New Albany, Ohio; Mount Carmel Health System, New Albany, Ohio.

Background: The shift toward outpatient joint arthroplasty is rapidly growing, but concerns still remain on whether certain patients should be excluded from same-day discharge arthroplasty. The purpose of this study is to evaluate whether morbid obesity is a risk factor for perioperative complications after outpatient joint arthroplasty.

Methods: A retrospective review was performed from 2013 to 2017 of all outpatient primary total hip, total knee, partial knee, and revision hip and knee arthroplasties, yielding a cohort of 4863 patients (5988 arthroplasty procedures). Read More

J Orthop Surg Res 2020 Jun 1;15(1):200. Epub 2020 Jun 1.

Department of Joint Surgery and Sports Medicine, Shanghai Changzheng Hospital, Second Military Medical University, No.415, Fengyang Road, Shanghai, 200003, China.

Background: Total hip arthroplasty (THA) is one of the most successful orthopedic surgeries. There are many common surgical approaches for THA. The direct anterior approach (DAA) and posterolateral approach (PLA) were compared, leading to controversial results. Read More

Gait Posture 2020 May 25;80:62-67. Epub 2020 May 25.

Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: The human tracking algorithm called OpenPose can detect joint points and calculate joint angles. However, the reliability and validity of OpenPose have not been clarified yet.

Research Question: Are there the enough reliability and validity of OpenPose based motion analysis?

Methods: 20 healthy young subjects participated in this study. Read More

Scand J Med Sci Sports 2020 Jun 2. Epub 2020 Jun 2.

Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Canada.

Compared to level running (LR), different strategies might be implemented by runners to cope with specific challenges of graded running at different speeds. The changes in joint kinetics and kinematics associated with graded running have been investigated but their interactions with speed are unknown. Nineteen participants ran on an instrumented treadmill at five grades (0°, ±5° and ±10°) and three speeds (2. Read More

J Orthop Res 2020 Jun 2. Epub 2020 Jun 2.

Division of Clinical Microbiology, Mayo Clinic, Rochester, MN.

There is interest in novel synovial fluid biomarkers for detection of periprosthetic joint infection (PJI). Here, we assessed the diagnostic accuracy of 23 simple or sophisticated synovial fluid biomarkers for prosthetic hip or knee infection detection. 107 subjects were studied, 57 of whom had aseptic failure (AF) and 50 PJI. Read More

Acta Clin Belg 2020 Jun 2:1-8. Epub 2020 Jun 2.

Department of Orthopaedics, University Hospital Brussels , Brussels, Belgium.

Objectives: Prosthetic joint infections (PJI) are treated with prolonged periods of intravenous (IV) antibiotics combined with one or more appropriate surgical procedures. In Belgium, patients receive their IV treatments as inpatients, whereas in other parts of the world similar IV antibiotics can be given as outpatient parenteral antibiotic therapy (OPAT), without jeopardising patient outcomes. The purpose of this paper was to analyse the financial feasibility of OPAT for PJI in Belgium. Read More

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020926790

Joint Orthopaedic Centre, Sydney, Australia.

Purpose: This study reports the results of a multimodal thromboprophylaxis protocol for lower limb arthroplasty involving risk stratification, intraoperative calf compression, aspirin prophylaxis and early (within 4 h) post-operative mobilisation facilitated by the use of local infiltration analgesia. The study also aimed to identify risk factors for venous thromboembolism (VTE) within a 3-month period following surgery for patients deemed not at elevated risk.

Methods: Patients undergoing knee/hip arthroplasty or hip resurfacing were preoperatively screened for VTE risk factors, and those at standard risk were placed on a thromboprophylaxis protocol consisting of intraoperative intermittent calf compression during surgery, 300 mg/day aspirin for 6 weeks from surgery and early mobilisation. Read More

Int Orthop 2020 Jun 1. Epub 2020 Jun 1.

Clinical Orthopedics, Department of Clinical and Molecular Science, School of Medicine, Università Politecnica delle Marche, via Tronto 10/A, 60126, Torrette di Ancona, Italy.

Purpose: Core decompression is a surgical option since the 1960s for hip osteonecrosis treatment. This technique promotes bone repair by reducing intramedullary pressure, but this is not often enough to stop the progression of necrosis. The aim of this study was to associate core decompression with the regenerative stimulus provided by platelet-rich plasma (PRP) and compare our results with other regenerative techniques. Read More

Basic Clin Neurosci 2020 Jan-Feb;11(1):1-14. Epub 2020 Jan 1.

Research Center of Biomedical Engineering, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Introduction: Efficient gait control using Functional Electrical Stimulation (FES) is an open research problem. In this research, a new intermittent controller has been designed to control the human shank movement dynamics during gait.

Methods: In this approach, first, the three-dimensional phase space was constructed using the human shank movement data recorded from the healthy subjects. Read More

J Am Acad Orthop Surg 2020 May 29. Epub 2020 May 29.

From the Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, NY (Dr. Litrenta, Dr. Masrouha, and Dr. Castaneda), and Middlesex Orthopedic, Middletown, CT (Dr. Wasterlain).

Ultrasonography is a valuable tool that can be used in many capacities to evaluate and treat pediatric orthopaedic patient. It has the capability to depict bone, cartilaginous and soft-tissue structures, and provide dynamic information. This technique can be readily applied to a wide range of pediatric conditions, including developmental dysplasia of the hip, congenital limb deficiencies, fracture management, joint effusions, and many other musculoskeletal pathologies. Read More

J Arthroplasty 2020 May 6. Epub 2020 May 6.

Division of Adult Reconstruction Surgery, Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, New York.

Background: High body mass index (BMI) has long been recognized as a risk factor for postoperative complication among total hip arthroplasty (THA) patients. However, recent studies showed mixed results in the effect of high BMI on surgical outcomes. Our study is to examine the association of preoperative BMI with complication incidence, stratified by age and gender. Read More

J Arthroplasty 2020 Apr 14. Epub 2020 Apr 14.

Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL.

Background: There is a growing body of literature on opioid mitigation strategies following total joint arthroplasty. However, these have almost exclusively been studied in populations undergoing primary procedures, with revision arthroplasty historically thought to be more resistant due to procedural variability and complexity. We report on opioid utilization for revision arthroplasty following implementation of a structured, standardized opioid reduction strategy. Read More

J Arthroplasty 2020 May 13. Epub 2020 May 13.

Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.

Background: Prosthetic joint infections (PJI) are a disastrous and feared complication in arthroplasty. Over the past decades, surgeons have tried to lower infection rates through all sorts of improvements. At present, it is impossible to reduce the risk to zero. Read More

Medicine (Baltimore) 2020 May;99(22):e20468

Department of Joint Surgery, Weifang People's Hospital.

Rationale: Although prosthetic loosening caused by poor prosthesis positioning is common after total hip arthroplasty (THA), an inflammation caused by poor prosthesis positioning is rare. We report a case in which a THA-related inflammation was indeed caused by poor prosthesis positioning.

Patient Concerns: A 64-year-old woman was admitted to our hospital with a history of persistent hip pain that had started after she had undergone THA 4 years previously. Read More

J Long Term Eff Med Implants 2019 ;29(3):247-254

Grant Medical Center, 285 East State Street, Suite 500, Columbus, OH 43215.

Background: The incidence of posttraumatic arthrosis after acetabular fractures is significant, and patients frequently require secondary total hip arthroplasty. Conversion arthroplasty is more technically difficult, and there is higher risk than with routine primary total hip arthroplasty. The goal of this study was to identify the challenges and risks of secondary total hip arthroplasty compared to primary total hip arthroplasty. Read More

Am J Pathol 2020 May 29. Epub 2020 May 29.

Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD, USA.

The most commonly reported symptom of post-Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection has not been well-characterized in human patients or animal models. By immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute infection by Ebola virus/Kikwit, Ebola virus/Makona-C05, and Marburg virus/Angola in the rhesus macaque model. Further, we demonstrate by histology, immunohistochemistry, RNAscope in situ hybridization, and transmission electron microscopy that synoviocytes of the stifle, shoulder, and hip are a target for mouse-adapted Ebola virus/Yambuku-Mayinga infection during acute disease in rhesus macaques. Read More