Search Our Scientific Publications & Authors

Calcif Tissue Int 2022 Jun 24. Epub 2022 Jun 24.

Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Purpose: A major challenge in osteoporosis is to identify individuals at high fracture risk. We investigated six bone turnover markers (BTMs) to determine association with specific fracture types; the time-frame for risk prediction and whether these are influenced by age at assessment.

Methods: Population-based OPRA cohort (n = 1044) was assessed at ages 75, 80, 85 and fractures documented for up to 15 years. Read More

J Bone Miner Res 2022 Jun 24. Epub 2022 Jun 24.

Department of Oncology and Metabolism, The University of Sheffield, Sheffield, S10 2RX, U.K.

The risk of osteoporotic fracture is inversely related to bone mineral density (BMD), but how spatial BMD pattern influences fracture risk remains incompletely understood. This study used a pixel-level spatio-temporal atlas of proximal femoral BMD in 13,338 white European women (age 20 to 97 years) to quantitate age-related texture variation in BMD maps and generate a 'reference' map of bone ageing. We introduce a new index, called Densitometric Bone Age (DBA), as the age at which an individual site-specific BMD map (the proximal femur is studied here) best matches the median ageing trajectory at that site in terms of the root mean squared error (RMSE). Read More

Front Biosci (Landmark Ed) 2022 Jun;27(6):181

State Key Laboratory of Natural Medicines, China Pharmaceutical University, 210009 Nanjing, Jiangsu, China.

Background: Avascular necrosis of the femoral head (AVNFH) is a progressive, multifactorial, and challenging clinical disease that causes hip pain and loss of hip joint function. Till now, the pathogenesis of AVNFH was not fully understood. In this study, we characterized cartilage protein profiles of patients with AVNFH and identified the potential proteins involved in the progress of AVNFH using proteomics technique. Read More

Cureus 2022 May 22;14(5):e25210. Epub 2022 May 22.

Orthopaedic Surgery, Wright State University, Dayton, USA.

Purpose Basicervical femoral neck fractures are uncommon injuries that occur at the extracapsular base of the femoral neck at its transition with the intertrochanteric line. Controversy remains in the orthopedic literature as to the optimal method of treatment for this fracture type given the inherent instability and greater rate of implant failure with traditional fixation constructs. The purpose of this study is to quantify the incidence and preferred treatment methods of basicervical hip fractures at a single, regional, Level 1 trauma center and to identify differences in postoperative complications between treatment options. Read More

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Department of Medicine, Surgery and Neuroscience, Section of Internal Medicine, University of Siena, 53100 Siena, Italy.

Background: Hip fragility fractures are becoming one of the main health care problems in countries with an aging population. This study aimed to evaluate the clinical characteristics and the usefulness of bone turnover markers in patients with a hip fracture.

Methods: In a cohort of 363 patients (84. Read More

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland.

Avascular necrosis (AVN) of the femoral head is caused by disruption of the blood supply to the proximal femur. The alterations in the blood supply may occur following a traumatic event or result from a non-traumatic cause. Femoral neck fracture and hip dislocation and associated surgical procedures, corticosteroid therapy, and alcohol abuse frequently lead to AVN development. Read More

Healthcare (Basel) 2022 Jun 8;10(6). Epub 2022 Jun 8.

Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, RO-020021 Bucharest, Romania.

Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. Read More

Healthcare (Basel) 2022 May 28;10(6). Epub 2022 May 28.

Department of Anaesthesia and Operating Theatre Services, Kwong Wah Hospital, 25 Waterloo Road, Yau Ma Tei, Hong Kong, China.

With an increasingly ageing population, there is a growing impact of fragility hip fracture on the healthcare system and on society as a whole. Oral and injectable analgesics are often insufficient whilst traction and regional blocks do not allow patients to be discharged easily. While the conventional approach of ultrasound-guided anterior hip pericapsular neurolysis can help a lot of inoperable hip fracture patients to relieve their fracture pain and facilitate subsequent nursing care, enormous technical challenges are encountered in some cases. Read More

Healthcare (Basel) 2022 May 25;10(6). Epub 2022 May 25.

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu 42415, Korea.

Patients with spinal cord injury (SCI) experience a high osteoporosis incidence, which increases fracture risk. Recently, a sclerostin antibody was introduced as a target biomarker to treat osteoporosis. We aimed to determine the serum concentration of sclerostin and factors affecting its concentration over time. Read More

Biomedicines 2022 Jun 8;10(6). Epub 2022 Jun 8.

BG Trauma Center Bergmannstrost, 06112 Halle (Saale), Germany.

Osteoarthritis (OA) alters chondrocyte metabolism and mitochondrial biology. We explored whether OA and non-OA chondrocytes show persistent differences in metabolism and mitochondrial function and different responsiveness to cytokines and cAMP modulators. Hip chondrocytes from patients with OA or femoral neck fracture (non-OA) were stimulated with IL-1β, TNF, forskolin and opioid peptides. Read More

Arch Osteoporos 2022 Jun 23;17(1):85. Epub 2022 Jun 23.

Section of Hematology and Coagulation at the Sahlgrenska University Hospital and Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

This study includes 1005 men from the Gothenburg part of the Osteoporotic Fracture in Men Study (MrOS). Included are 66 men with anemia (hemoglobin < 130 g/L). The follow-up time was up to 16 years, and the main results are that anemia is associated with all fractures and non-vertebral osteoporotic fractures. Read More

J Arthroplasty 2022 Jun 20. Epub 2022 Jun 20.

Hospital for Special Surgery, 535 E 70th St, New York, NY. Electronic address:

Background: Osteoporosis is a major risk factor for peri-prosthetic fractures (PPFx) in total hip arthroplasty (THA) patients, but is not routinely screened for in this population. Given the availability of hip x-rays and pre-op screenings, Fracture Risk Assessment Tool (FRAX) scores and radiographic bone measurements are potential promising, novel risk stratification tools. This study aims to characterize FRAX scores and radiographic bone measurements in THA and PPFx patients. Read More

J Arthroplasty 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; Arthritis and Arthroplasty Design Lab, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA; Department of Bioengineering, and Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, PA. Electronic address:

Introduction: Revision total hip arthroplasty (THA) for adverse local tissue reactions (ALTRs) secondary to head-neck taper corrosion is associated with a high complication rate. Diagnosis of ALTR is based on risk stratification using the patient's history and examination, implant risk, serum metal ion levels, and imaging. The purpose of this study was to determine if stratification using similar risk factors is predictive of outcomes following revision THA for metal-on-polyethylene (MoP) ALTR. Read More

J Arthroplasty 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopedic Surgery, NYU Langone Health, New York, New York. Electronic address:

Introduction: Demographic variables play an important role in outcomes following revision total hip arthroplasty (rTHA). Surgical and in-patient variables as well as outcomes vary between indications for rTHA. The purpose of this study was to investigate the impact of the indication for the rTHA on costs and postoperative outcomes. Read More

Geroscience 2022 Jun 23. Epub 2022 Jun 23.

Department of Medicine, Duke University School of Medicine, Durham, NC, 27701, USA.

Translating our knowledge of the biological aging from animal models to humans may give rise to novel approaches of targeting multiple aging-related diseases simultaneously and increasing health span. Here, for the first time, we use transcriptomic signatures of monocytes to identify biological aging pathways underlying multiple aging-related diseases in humans. The ordinal logistic regression was used to cross-sectionally investigate transcriptomics of the comorbidity index in 1264 community-based Multi-Ethnic Study of Atherosclerosis (MESA) adults, 47% Caucasian, 32% Hispanic, 21% African American, and 51% female, aged 55-94 years. Read More

Arch Orthop Trauma Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Trauma Surgery, University Medical Centre Regensburg, Franz‑Josef‑Strauss Allee 11, 93053, Regensburg, Germany.

Introduction: Intracapsular femoral neck fractures are one of the most common fractures in Germany. Nevertheless, the epidemiology and treatment modalities are not described comprehensively. For this reason, this study highlights the epidemiology of femoral neck fractures in different age groups and summarizes treatment strategies within the period from 2009 to 2019 based on nationwide data. Read More

Ned Tijdschr Geneeskd 2022 May 12;166. Epub 2022 May 12.

St. Antonius Ziekenhuis, afd. Anesthesiologie, Intensive Care en Pijnbestrijding, Nieuwegein.

There have been concerns about the negative effects of general anaesthesia in elderly hip fracture patients. For full informed consent, data from carefully designed clinical trials with functional outcome measures in older patients are essential. The development and implementation of such knowledge can be improved by using standardized functional outcomes in perioperative research. Read More

J Orthop Res 2022 Jun 23. Epub 2022 Jun 23.

Department for Orthopaedics and Traumatology, Kepler University Hospital GmbH, Johannes Kepler University Linz, Krankenhausstrasse 9, 4020 Linz and Altenberger Strasse 69, 4040, Linz, Austria.

To biomechanically evaluate the stability of a diaphyseal anchored, cementless stem in presence of a proximal periprosthetic femoral medial wall defect compared to the stability of the same stem in an intact femur.

Methods: Twenty-two paired human cadaveric femora were pairwise assigned either to a fracture group, featuring a proximal medial wall defect involving 40% of the stems medial anchorage distance, or a control group with native specimens. The specimens were tested under a monotonically increasing cyclic axial loading protocol. Read More

Harefuah 2022 Jun;161(6):361-366

Rambam Medical Center.

Introduction: Cycling in Israel: Cycling in Israel is a common sport which is considered to be beneficial to health. However, questions arise about its impact on bone health, due to publications reporting a decrease in bone density in cyclists and the presence of fractures that characterize a relatively older population in relatively young cyclists. Exercise and bone health: It has been proven that a sporty lifestyle, exercise in general and cycling in particular, lowers the chance of fractures of the proximal femur. Read More

J Orthop 2022 Jul-Aug;32:151-155. Epub 2022 Jun 8.

Department of Orthopaedics, Phramongkutklao Hospital, Bangkok, Thailand.

Background: Intertrochanteric fracture is one of the most burdensome osteoporotic fractures in the elderly. Chronic kidney disease is associated with sarcopenia, especially in its advanced stages and, thus may impact functional status. Combining an intertrochanteric fracture with advanced CKD may diminish results after surgical fixation. Read More

Adv Orthop 2022 13;2022:5863813. Epub 2022 Jun 13.

Department of General Surgery and Medical Surgical Specialties, Section of Orthopaedics and Traumatology, University Hospital Policlinico-San Marco, University of Catania, Catania, Italy.

Background: Proximal humerus fractures (PHFs) are one of the most frequent fractures in the elderly and are the third most fractures after those of the hip and wrist. PHFs are assessed clinically through conventionally standard imaging (X-ray and computed tomography (CT) scans). The present study aims to conduct the diagnostic evaluation and therapeutic efficacy of the 3D-printed models (3DPMs) for the PHFs, compared with the standard imaging. Read More

BMC Musculoskelet Disord 2022 Jun 22;23(1):601. Epub 2022 Jun 22.

Department of Operation Room, The Second Affiliated Hospital and Yuying Children's Hospital of WenZhou Medical University, WenZhou, 325000, ZheJiang, China.

Background: Displacement of the lesser trochanter (LT) is not uncommon after managing intertrochanteric femoral fractures and the influence of nonunion of the LT-fragment on clinical outcomes remains controversial. This study aimed to investigate the relationship between the displacement distance and union of the LT-fragment and evaluate the influence of LT-fragment nonunion on hip function and complications.

Methods: This retrospective study included patients with intertrochanteric fractures and displaced LT treated with intramedullary fixation at Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from June 2015 to July 2017. Read More

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3878-3885

Department of Orthopedics and Traumatology, Health Sciences University, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.

Objective: We aimed at investigating the relationship between the values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) in the preoperative and postoperative periods in patients who underwent hemiarthroplasty.

Patients And Methods: The medical records of patients aged >65 years who underwent hemiarthroplasty due to hip fracture in our institution between January 2017 and December 2020 were examined. Dynamic Neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (dPLR), and systemic immune-inflammation index (dSII) were calculated using biomarker data (neutrophil, lymphocyte, and platelet counts) obtained at admission and on postoperative day 2 and 5. Read More

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):3872-3877

Department of Orthopedics, Dafeng People's Hospital, Yancheng, Jiangsu, China.

Objective: To explore the clinical effect of bone cement-enhanced Asian proximal femoral anti-rotation intramedullary nail (APFN) internal fixation in the treatment of elderly osteoporotic intertrochanteric fractures of the femur and provide it as a more robust treatment to elderly patients with osteoporotic intertrochanteric femoral fractures.

Patients And Methods: Between January 2017 and January 2019, 42 patients with osteoporotic intertrochanteric fractures in our hospital were selected. All patients were randomly divided into the proximal femoral anti-rotation intramedullary nail (PFNA) group and APFN group. Read More

J Orthop Res 2022 Jun 22. Epub 2022 Jun 22.

Department of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran.

Computational fracture analysis has become a growing branch in orthopaedic research. Particularly, the associated methods provide reliable tools for the analysis of 3D CT-based models of bone. This paper reports the results of such analyses for 15 human femora (healthy and osteoporotic) under different loading orientations (85 different analysis cases). Read More

AIDS 2022 Jun 23. Epub 2022 Jun 23.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Fracture rates have been reported to be higher among older women living with HIV (WLWH) than HIV- women. Hormone therapy with estrogen can reduce vasomotor symptoms (VMS) associated with menopause and prevent fractures. As data are limited on the benefits of hormone therapy use in WLWH, we examined associations of hormone therapy, use and fractures. Read More

Zhongguo Gu Shang 2022 Jun;35(6):520-6

Division of Sports Medicine and Adult Reconstructive Surgery, the Affiliated Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing 210000, Jiangsu, China.

Objective: To evaluate effectiveness of self-designed adjustable cannulated screw guide, and to provide an effective auxiliary tool for inverted triangular arrangement of compression cannulated screws in clinical treatment for transcervical femoral neck fractures.

Methods: The sketch of instrument was drawn with Solidworks software, and physical product was obtained after production. The data were obtained by Mimics software. Read More

BMC Anesthesiol 2022 Jun 21;22(1):192. Epub 2022 Jun 21.

Department of Anaesthesiology and Intensive Care, Copenhagen University Hospital, Nordsjællands Hospital, Hillerød, Denmark.

Systematic reviews associate peripheral nerve blocks based on anatomic landmarks or nerve stimulation with reduced pain and need for systemic analgesia in hip fracture patients. We aimed to investigate the effect of ultrasound-guided nerve blocks compared to conventional analgesia for preoperative pain management in hip fractures. Five databases were searched until June 2021 to identify randomised controlled trials. Read More

Clin Orthop Relat Res 2022 Jun 10. Epub 2022 Jun 10.

New York University Langone Health, New York, NY, USA.

Clin Orthop Relat Res 2022 Jun 9. Epub 2022 Jun 9.

Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, USA.