583,645 results match your criteria High Blood Pressure & Cardiovascular Prevention[Journal]


Maternal hypertension and survival in singletons and twins born at 23-29 weeks: not just one answer….

Pediatr Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics and Gynecology, McGill University Health Centre, Montreal, QC, Canada.

Objective: To describe the association between maternal hypertension (chronic and gestational, MH) and mortality in very preterm singletons and twins, focusing on how estimates depend on gestational age (GA) and size at birth.

Methods: We estimated relative risks of in-hospital death in 12,320 singletons (MH: 22.4%) and 4381 twins (MH: 10. Read More

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http://dx.doi.org/10.1038/s41390-019-0337-4DOI Listing
February 2019

Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes.

Ann Nutr Metab 2019 Feb 14;74(2):165-174. Epub 2019 Feb 14.

Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada,

Background: Postprandial metabolic impairments in diabetes have been shown to play an important role in vascular complications. Dietary polyphenols and other bioactive compounds in berries have been shown to improve postprandial hyperglycemia and related metabolic impairments, but few clinical studies have been reported in diabetes.

Objective: To examine the effects of daily dietary raspberries on postprandial and 4-week fasting glucose, lipids and biomarkers of inflammation in obese adults with type 2 diabetes. Read More

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http://dx.doi.org/10.1159/000497226DOI Listing
February 2019

Comparative Analysis Using Propensity Score Matching Analysis: Primary Closure Versus Patch Angioplasty During Carotid Endarterectomy.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Division of Vascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Background: Primary closure (PC) and patch angioplasty (PA) during carotid endarterectomy (CEA) have been disputed in many studies. Some studies announced that PC is associated with a higher restenosis rate. The aim of this study was to evaluate the outcomes of PC and PA using propensity score matching (PSM). Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.011DOI Listing
February 2019

Association betweenPNPLA3rs738409, polymorphism, decreased kidney function in postmenopausal type 2, diabetic women with or without non-alcoholic fatty liver disease.

Diabetes Metab 2019 Feb 11. Epub 2019 Feb 11.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University Hospital of Verona, Verona, Italy. Electronic address:

Aim: - Evidence is emerging that PNPLA3 rs738409 polymorphism (the major genetic variant associated with susceptibility to non-alcoholic fatty liver disease [NAFLD]) is associated with chronic kidney disease (CKD) in non-diabetic individuals. Currently, little is known about this association in type 2 diabetic (T2DM) patients with and without NAFLD.

Methods: - We studied 101 Caucasian post-menopausal women with T2DM, consecutively attending our diabetes outpatient service during a 3-month period. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.011DOI Listing
February 2019

Mucoadhesive olaminosomes: A novel prolonged release nanocarrier of agomelatine for the treatment of ocular hypertension.

Int J Pharm 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt. Electronic address:

Mucoadhesive olaminosomes are novel nanocarriers designed to control agomelatine release and enhance its bioavailability. Olaminosomes were prepared using oleic acid, oleylamine and sorbitan monooleate adopting thin film hydration technique. Chitosan HCl was added to impart the mucoadhesive properties to the olaminosomes. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.070DOI Listing
February 2019

Cardiac Function After Radiotherapy for Breast Cancer.

Int J Radiat Oncol Biol Phys 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30, 001, 9700 RB Groningen, The Netherlands. Electronic address:

Purpose: The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT).

Methods And Materials: We conducted a cross-sectional study consisting of 109 BC survivors treated with RT between 2005 and 2011. The endpoint was cardiac function, assessed by echocardiography. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.003DOI Listing
February 2019

The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery.

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.001DOI Listing
February 2019

Cardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females: The Enigma Study

Hypertension 2018 Dec 15;72(6):1277-1284. Epub 2018 Oct 15.

Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, United Kingdom

Blood pressure (BP) in young adults predicts BP in later life. We aimed to identify metabolic, hemodynamic, and autonomic characteristics associated with raised BP in young adults and whether these differ between males and females. Three thousand one hundred forty-five healthy subjects, aged 18 to 40 years, were grouped according to sex and BP category following the recent reclassification of BP as part of American Heart Association/American College of Cardiology 2017 guidelines. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11975DOI Listing
December 2018

Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan)

Hypertension 2019 Jan 19;73(1):52-59. Epub 2018 Nov 19.

Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo

Lifetime risk (LTR) provides an absolute risk assessment during the remainder of one’s life. Few studies have focused on the LTRs of stroke and coronary heart disease (CHD), categorized by fine blood pressure in Asian populations. We aimed to assess it using a large database of a meta-analysis with the individual participant data. Read More

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https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.
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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11635DOI Listing
January 2019
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The ability of thromboelastography parameters to predict severe pre-eclampsia when measured during early pregnancy.

Int J Gynaecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: To examine the predictive value of thromboelastography parameters during early pregnancy as potential markers of severe pre-eclampsia during late pregnancy.

Methods: An observational retrospective case-control study was conducted among pregnant women who attended a single hospital in Shanghai, China, between July 1, 2016, and February 31, 2018. Data were obtained from medical records and a structured questionnaire completed by the participants. Read More

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http://dx.doi.org/10.1002/ijgo.12785DOI Listing
February 2019

Effects of angiotensin converting enzyme gene polymorphism on hypertension in Africa: A meta-analysis and systematic review.

PLoS One 2019 14;14(2):e0211054. Epub 2019 Feb 14.

School of Pharmacy, College of Health and Medical Sciences, Haramaya Univeristy, Harar, Ethiopia.

Background: Hypertension is dramatically increasing in Africa with evidence of increased severity and resistance to treatment. Although angiotensin converting enzyme gene polymorphism is associated with higher prevalence of hypertension, the evidence is inconclusive on its influence on the emerging pattern in Africa. This meta-analysis is conducted to pool the available evidence to inform future research and interventions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211054PLOS
February 2019

Indications for echocardiography of replacement heart valves: a joint statement from the BHVS and BSE.

Echo Res Pract 2019 Feb 1. Epub 2019 Feb 1.

R Steeds, Cardiology, University Hospital of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Echocardiography plays a vital role in the follow up of patients with replacement heart valves. However, there is considerable variation in international guidelines regarding the recommended time points after implantation at which routine echocardiography should be performed. The purpose of routine echocardiography is to detect early structural valve deterioration in biological valves to improve the timing of redo interventions. Read More

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http://dx.doi.org/10.1530/ERP-18-0079DOI Listing
February 2019

Hypertensive ocular disease in cats: A guide to fundic lesions to facilitate early diagnosis.

Authors:
Jenny Carter

J Feline Med Surg 2019 Jan;21(1):35-45

Auckland, New Zealand.

Practical Relevance:: Systemic hypertension is common in older cats and can result in damage to organs with a rich arteriolar supply such as the eyes, kidneys, myocardium and brain. Hypertensive disease in these organs is known as target organ damage (TOD). Disease in the eye resulting from hypertension is the most easily identifiable form of TOD and can often be the reason the cat is presented to the veterinarian. Read More

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http://dx.doi.org/10.1177/1098612X18818668DOI Listing
January 2019

Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer.

N Engl J Med 2019 Feb 14. Epub 2019 Feb 14.

From Institut Gustave Roussy, Université Paris-Sud, Villejuif, France (K.F.); Carolina Urologic Research Center, Myrtle Beach, SC (N.S.); Tampere University Hospital and University of Tampere, Tampere (T.L.T.), and Orion Pharma, Orion Corporation, Espoo (A.S., T.S.) - all in Finland; National Cancer Institute, Vilnius (A.U.), and Medical Academy, Lithuanian University of Health Sciences, Kaunas (M.J.) - both in Lithuania; Stradins Clinical University Hospital, Riga, Latvia (E.V.); N.N. Alexandrov National Cancer Center of Belarus, Minsk, Belarus (S.P.); Hospital Erasto Gaertner, Curitiba, Brazil (M.L.); National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Moscow (B.A.); Bayer, Berlin (I.K., C.K.); and Massachusetts General Hospital Cancer Center, Boston (M.R.S.).

Background: Darolutamide is a structurally unique androgen-receptor antagonist that is under development for the treatment of prostate cancer. We evaluated the efficacy of darolutamide for delaying metastasis and death in men with nonmetastatic, castration-resistant prostate cancer.

Methods: We conducted a randomized, double-blind, placebo-controlled, phase 3 trial involving men with nonmetastatic, castration-resistant prostate cancer and a prostate-specific antigen doubling time of 10 months or less. Read More

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http://dx.doi.org/10.1056/NEJMoa1815671DOI Listing
February 2019

Impact of hepatitis C virus and insurance coverage on mortality.

Am J Manag Care 2019 Feb;25(2):61-67

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Claude Moore Health Education and Research Building, 3300 Gallows Rd, Falls Church, VA 22042. Email:

Objectives: To assess the association of payer status and mortality in hepatitis C virus (HCV)-infected patients.

Study Design: For this retrospective observational study, we used the National Health and Nutrition Examination Survey from 2000 to 2010. Adults with complete data on medical questionnaires, HCV RNA, insurance types, and mortality follow-ups were included. Read More

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February 2019
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Recommendations for ultrasonographic assessment of renal arteries.

J Ultrason 2018 ;18(75):338-343

Department of General Surgery and Endocrinology, Medical University of Warsaw , Poland.

The present clinical practice recommendations are addressed to physicians of all specialties, who perform Doppler ultrasound examinations of the kidneys on a daily basis, and in particular to specialists in radiology and imaging diagnostics. The recommendations were based on the Ultrasonography Standards of the Polish Ultrasound Society and current scientific reports consistent with Evidence Based Medicine. The paper discusses patient preparation protocol, examinat ion technique with particular emphasis on patient's position allowing to obtain proper Doppler angle of insonation, as well as diagnostic limitations of the technique. Read More

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http://dx.doi.org/10.15557/JoU.2018.0049DOI Listing
January 2018

Prevalence, Treatment and Outcomes of Coexistent Pulmonary Hypertension and Interstitial Lung Disease in Systemic Sclerosis.

Arthritis Rheumatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Rheumatology, Department of Internal Medicine, University of Michigan.

Objective: Systemic sclerosis (SSc) is associated with interstitial lung disease (ILD) and pulmonary hypertension (PH). We sought to determine prevalence, characteristics, treatment, and outcomes for subjects with PH in a SSc-associated ILD (SSc-ILD) cohort.

Methods: Subjects with SSc-ILD on high resolution computed tomography (HRCT) were included in a prospective observational cohort. Read More

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http://dx.doi.org/10.1002/art.40862DOI Listing
February 2019

Effect of oxidative stress in rostral ventrolateral medulla on sympathetic hyperactivity after traumatic brain injury.

Eur J Neurosci 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Sympathetic hyperactivity occurs in a subgroup of patients after traumatic brain injury (TBI). The rostral ventrolateral medulla (RVLM) is a key region for the activity of sympathetic nervous system. Oxidative stress in the RVLM is proved to be responsible for the increased level of sympathetic activity in animal models of hypertension and heart failure. Read More

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http://dx.doi.org/10.1111/ejn.14374DOI Listing
February 2019

Patient costs of hypertension care in public health care facilities in Kenya.

Int J Health Plann Manage 2019 Feb 14. Epub 2019 Feb 14.

Health Economics Research Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.

Background: Hypertension in low- and middle-income countries, including Kenya, is of economic importance due to its increasing prevalence and its potential to present an economic burden to households. In this study, we examined the patient costs associated with obtaining care for hypertension in public health care facilities in Kenya.

Methods: We conducted a cross-sectional study among adult respondents above 18 years of age, with at least 6 months of treatment in two counties. Read More

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http://dx.doi.org/10.1002/hpm.2752DOI Listing
February 2019

Effect of Home Medication Titration on Blood Pressure Control in Patients With Hypertension: A Meta-Analysis of Randomized Controlled Trials.

Med Care 2019 Mar;57(3):230-236

Department of Mathematics, Tamkang University, Taipei, Taiwan.

Background: Medication titration has been used in home blood pressure (BP) control, with the expectation of enabling patients with hypertension to better manage their BP.

Objective: The study goal was to estimate the effects of medication titration intervention in lowering the systolic blood pressure and diastolic blood pressure of patients with hypertension.

Methods: The meta-analysis included randomized controlled trials on adults diagnosed with hypertension and BP≧130/80 mm Hg, having a medication-titration intervention, and using a home BP measurement. Read More

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http://dx.doi.org/10.1097/MLR.0000000000001064DOI Listing

Risk of subsequent health disorders among living kidney donors.

Medicine (Baltimore) 2019 Feb;98(7):e14494

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University.

Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens.We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. Read More

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http://dx.doi.org/10.1097/MD.0000000000014494DOI Listing
February 2019

Increased risk of neurodegenerative dementia in women with migraines: A nested case-control study using a national sample cohort.

Medicine (Baltimore) 2019 Feb;98(7):e14467

Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.

The present study aimed to evaluate the association between migraines and dementia.Data were collected from 11,438 dementia participants who were 1:4 matched by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia with 45,752 controls from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Dementia was diagnosed using the International Classification of Disease-10 (ICD-10) codes (G30 or F00). Read More

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http://dx.doi.org/10.1097/MD.0000000000014467DOI Listing
February 2019

The association between human papillomavirus infection and head and neck cancer: A population-based cohort study.

Medicine (Baltimore) 2019 Feb;98(7):e14436

School of Medicine, Chung Shan Medical University.

Human papillomavirus (HPV) has been linked with development of oropharyngeal squamous cell carcinoma, a subset of head and neck cancer (HNC). This study aimed to evaluate the association between HPV infection and subsequent development of HNC and to report epidemiological information in Taiwan.This population-based cohort study retrieved patient data from the longitudinal health insurance database (LHID) of Taiwan's National Health Insurance Research Database (NHIRD) from 2005 to 2010 and analyzed it retrospectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000014436DOI Listing
February 2019

Headaches in Idiopathic Intracranial Hypertension.

J Neuroophthalmol 2019 Mar;39(1):82-93

Departments of Neurology and Neurotherapeutics and Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Headache is the most common symptom of idiopathic intracranial hypertension (IIH) and may not resolve with intracranial pressure-lowering treatments. Many patients with IIH have a pre-existing history of migraine. Approximately two-thirds of patients with IIH continue to experience headaches after the other manifestations of the disorder resolve. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000777DOI Listing

Intraoperative anesthetic management of the liver transplant recipient with portopulmonary hypertension.

Authors:
Sherif Kandil

Curr Opin Organ Transplant 2019 Feb 11. Epub 2019 Feb 11.

Department of Anesthesiology, Keck Medical School of USC, Los Angeles, California, USA.

Purpose Of Review: Liver transplantation in patients with portopulmonary hypertension (POPH) is associated with increased perioperative risk. Important recent advances in the management of liver transplantation recipients with POPH are discussed.

Recent Findings: The presence of POPH at the time of liver transplantation should not be a contraindication for liver transplantation, as POPH is common and may be related to volume overload and/or high cardiac output (CO). Read More

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http://dx.doi.org/10.1097/MOT.0000000000000613DOI Listing
February 2019

Blood pressure targets and kidney and cardiovascular disease: same data but discordant guidelines.

Curr Opin Nephrol Hypertens 2019 Feb 12. Epub 2019 Feb 12.

William B. Schwartz Division of Nephrology, Tufts Medical Center, Boston, Massachusetts, USA.

Purpose Of Review: Hypertension is highly prevalent in the United States and a major risk factor for the development of cardiovascular disease. Hypertension is common in chronic kidney disease (CKD), and likely contributes to the association between CKD and cardiovascular disease. The ideal systolic BP to reduce cardiovascular disease risk in individuals with CKD is controversial. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000492DOI Listing
February 2019

Validation of noninvasive oscillometric blood pressure 2020 up pressure upper arm blood pressure monitoring technology according to the European Society of Hypertension International Protocol revision 2010.

Blood Press Monit 2019 Feb 11. Epub 2019 Feb 11.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Department of Nephrology.

To validate noninvasive oscillometric blood pressure (NIBP) 2020 up pressure (UP) upper arm blood pressure (BP) monitoring technology according to the European Society of Hypertension International Protocol revision 2010 (ESH-IP revision 2010). According to the protocol, 33 participants were included. NIBP2020 UP technology was integrated into the BP+ host device, and common upper arm cuffs were used. Read More

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http://dx.doi.org/10.1097/MBP.0000000000000370DOI Listing
February 2019

Management of oral anticoagulation after intracerebral hemorrhage.

Int J Stroke 2019 Feb 14:1747493019828555. Epub 2019 Feb 14.

Department of Neurology, University Hospital Erlangen, Erlangen, Germany.

Background: The most recent years have significantly expanded knowledge regarding risks and benefits of resuming oral anticoagulation (OAC) after intracerebral hemorrhage (ICH). No randomized data is yet available, though several large observational studies and meta-analyses have investigated the impact of resuming OAC on thromboembolic versus hemorrhagic complications in these high-risk patients after ICH.

Aims: The present review will summarize the most important studies conducted over the last years and will focus on relevant factors help guiding on decision-making on whether to start OAC after ICH. Read More

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http://dx.doi.org/10.1177/1747493019828555DOI Listing
February 2019

Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis.

Int J Stroke 2019 Feb 14:1747493019830321. Epub 2019 Feb 14.

1 Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences and Edinburgh Imaging, University of Edinburgh, Edinburgh, UK.

Background: Perivascular spaces, visible on brain magnetic resonance imaging, are thought to be associated with small vessel disease, neuroinflammation, and to be important for cerebral hemodynamics and interstitial fluid drainage.

Aims: To benchmark current knowledge on perivascular spaces associations with risk factors, neurological disorders, and neuroimaging lesions, using systematic review and meta-analysis.

Summary Of Review: We searched three databases for perivascular spaces publications, calculated odds ratios with 95% confidence interval and performed meta-analyses to assess adjusted associations with perivascular spaces. Read More

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http://dx.doi.org/10.1177/1747493019830321DOI Listing
February 2019

Chronic medical conditions in U.S. adults with incarceration history.

Authors:
Tomoko Udo

Health Psychol 2019 Mar;38(3):217-225

University at Albany, State University of New York.

Objectives: To examine the associations between incarceration history and chronic medical conditions in a nationally representative sample of U.S. adults and whether risk for chronic medical conditions differ by sex and race among those with incarceration history. Read More

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http://dx.doi.org/10.1037/hea0000720DOI Listing

Oral nutritional supplements and 30-day readmission rate in hypoalbuminemic maintenance hemodialysis patients.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Division of Nephrology, Department of Medicine, Tufts Medical Center, Boston, Massachusetts, USA.

Introduction: Hemodialysis (HD) patients are hospitalized nearly twice yearly, and 35% of these patients are rehospitalized within 30-days postdischarge. We hypothesized that monitored oral nutritional supplementation (ONS) during HD treatment may decrease readmissions.

Methods: A cohort of maintenance HD patients, treated at a large dialysis organization, who were hospitalized with a postdischarge albumin of ≤3. Read More

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http://dx.doi.org/10.1111/hdi.12694DOI Listing
February 2019

Body Weight and eGFR during Dulaglutide Treatment in Type 2 Diabetes and Moderate-to-Severe Chronic Kidney Disease (AWARD-7).

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

Eli Lilly and Company, Indianapolis, IN, USA.

In patients with T2D and moderate-to-severe CKD, dulaglutide treatment led to body weight (BW) loss and lesser eGFR decline compared to insulin glargine. Since BW may affect muscle mass, creatinine-based eGFR can be altered independent of kidney function. Cystatin C-based eGFR is not affected by muscle mass. Read More

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http://dx.doi.org/10.1111/dom.13668DOI Listing
February 2019

Uric acid and the cardio-renal effects of SGLT2 inhibitors.

Diabetes Obes Metab 2019 Feb 14. Epub 2019 Feb 14.

School of Life and Health Sciences, Aston University, Birmingham, UK.

Sodium/glucose co-transporter-2 (SGLT2) inhibitors, which lower blood glucose by increasing renal glucose elimination have been shown to reduce the risk of adverse cardiovascular (CV) and renal events in type 2 diabetes. This has been ascribed in part to haemodynamic changes, body weight reduction and several possible effects on myocardial, endothelial and tubulo-glomerular functions as well as reduced glucotoxicity. This review evaluates evidence that an effect of SGLT2 inhibitors to lower uric acid may also contribute to reduced cardio-renal risk. Read More

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http://dx.doi.org/10.1111/dom.13670DOI Listing
February 2019

The reduction of apnea-hypopnea duration ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in a rat model of obstructive sleep apnea.

Sleep Breath 2019 Feb 14. Epub 2019 Feb 14.

Beijing An Zhen Hospital, Capital Medical University, #2 Anzhen Road, Chaoyang District, Beijing, 100029, People's Republic of China.

Purpose: We aimed to investigate the effect of obstructive sleep apnea (OSA) and apnea-hypopnea duration on endothelial, ventricular function, blood pressure, and inflammation in a rat model.

Methods: We established a novel rat model of OSA. Wistar rats were randomized to six groups according to 4-week different treatments: (1) OSA (apnea for 60 s in a 90-s window of breathing [60 s/90 s] with anesthesia), (2) OSA 30 s/90 s with anesthesia, (3) partial recovery (60 s/90 s for 2 weeks, followed by 15 s/90 s for 2 weeks with anesthesia), (4) complete recovery (60 s/90 s for 2 weeks with anesthesia, and then normal breathing for 2 weeks), (5) sham (normal breathing in the device with anesthesia), and (6) control group (normal breathing, normal cage, no anesthesia). Read More

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http://dx.doi.org/10.1007/s11325-019-01798-3DOI Listing
February 2019

Schizophrenia and pregnancy: a national register-based follow-up study among Finnish women born between 1965 and 1980.

Arch Womens Ment Health 2019 Feb 14. Epub 2019 Feb 14.

Forensic Psychiatry, Helsinki University and Helsinki University Hospital, Psykiatriakeskus, P.O. Box 590, 00029, HUS, Finland.

To assess psychosocial and somatic risk factors related to pregnancy, and pregnancy-related complications or disorders in women with schizophrenia compared to population controls. In this register-based cohort study, we identified all Finnish women who were born in 1965-1980 and diagnosed with schizophrenia in psychiatric care before 31 December 2013. For each case, five age- and place-of-birth matched controls were randomly selected. Read More

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http://dx.doi.org/10.1007/s00737-019-0948-0DOI Listing
February 2019

Preterm Birth Is a Novel, Independent Risk Factor for Altered Cardiac Remodeling and Early Heart Failure: Is it Time for a New Cardiomyopathy?

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Level 1, John Radcliffe Hospital, Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.

Purpose Of Review: Around 10% of the global population is born preterm (< 37 weeks' gestation). Preterm birth is associated with an increased risk of cardiovascular events, with preterm-born individuals demonstrating a distinct cardiac phenotype. This review aims to summarize the main phenotypic features of the preterm heart and directions for future research to develop novel intervention strategies. Read More

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http://dx.doi.org/10.1007/s11936-019-0712-9DOI Listing
February 2019

Renal Artery Denervation for Hypertension.

Curr Treat Options Cardiovasc Med 2019 Feb 14;21(2). Epub 2019 Feb 14.

Duke University Medical Center, 2301 Erwin Rd, Durham, NC, 27710, USA.

Purpose Of Review: Hypertension (HTN) has a growing impact, already affecting over 1 billion people. An estimated 2-16% of those with HTN have resistant HTN. The sympathetic nervous system (SNS) is a recognized contributor to the pathophysiology of resistant HTN. Read More

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http://dx.doi.org/10.1007/s11936-019-0715-6DOI Listing
February 2019

Morphometric demonstration of portal vein stenosis and hepatic arterial medial hypertrophy in patients with biliary atresia.

Pediatr Surg Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatric Surgery, Research Field in Medical and Health Sciences, Medical and Dental Area, Research and Education Assembly, Kagoshima University, 8-35-1, Sakuragaoka, Kagoshima, 890-8520, Japan.

Purpose: Portal hypertension in patients with biliary atresia (BA) is generally thought to result from portal vein (PV) narrowing secondary to hepatic fibrosis. To test the hypothesis, we morphometrically analyzed the PVs and hepatic arteries (HAs).

Methods: Morphometrical analyses of 25 BA and 26 non-BA liver biopsy specimens from patients treated from 2000 to 2014. Read More

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http://dx.doi.org/10.1007/s00383-019-04459-4DOI Listing
February 2019

Reduction of exposure to tacrolimus trough level variability is associated with better graft survival after kidney transplantation.

Eur J Clin Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Department of Nephrology and Hypertension, Rabin Medical Center, Beilinson campus, 39, Jabutinsky st., Petah Tikva, Israel.

Purpose: High tacrolimus trough drug level variability was found to be associated with reduced graft survival. The primary goal of this study was to find whether reduction of exposure to high tacrolimus trough level variability in patients in which previously had high variability was associated with better graft survival.

Methods: All tacrolimus drug level values in patients that underwent kidney transplantation at our center between 2006 and 2015 were collected. Read More

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http://dx.doi.org/10.1007/s00228-019-02643-yDOI Listing
February 2019

Sympathetic stimulation with norepinephrine may come at a cost.

Neural Regen Res 2019 Jun;14(6):977-978

Dobney Hypertension Centre, School of Biomedical Science - Royal Perth Hospital Unit, University of Western Australia, Perth, Australia.

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http://dx.doi.org/10.4103/1673-5374.250576DOI Listing

Sociodemographic patterns of urine sodium excretion and its association with hypertension in Chile: a cross-sectional analysis.

Public Health Nutr 2019 Feb 14:1-10. Epub 2019 Feb 14.

1BHF Glasgow Cardiovascular Research Centre,Institute of Cardiovascular and Medical Science,University of Glasgow,Glasgow G12 8TA,UK.

Objective: The aim of the study was to determine the main factors (sociodemographic, anthropometric, lifestyle and health status) associated with high Na excretion in a representative population of Chile.

Design: Na excretion (g/d), a valid marker of Na intake, was determined by urine analysis and Tanaka's formulas. Blood pressure was measured by trained staff and derived from the mean of three readings recorded after 15 min rest. Read More

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http://dx.doi.org/10.1017/S1368980018003889DOI Listing
February 2019

Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.

Neurol Res 2019 Feb 14:1-6. Epub 2019 Feb 14.

b Department of Neurology , The Second Affiliated Hospital of Zhengzhou University , Zhengzhou , China.

Objective: The objective of this study was to investigate the expression of serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) and their correlation with clinicopathological features.

Methods: Fifty AD subjects and 50 healthy controls were enrolled in this study. Enzyme-linked immunosorbent assay (ELISA) was used to determine the expression of TRF1 and TRF2 in the peripheral blood plasma. Read More

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http://dx.doi.org/10.1080/01616412.2019.1580456DOI Listing
February 2019

Endogenous circulating testosterone and sex hormone-binding globulin levels and measures of myocardial structure and function: the Framingham Heart Study.

Andrology 2019 Feb 13. Epub 2019 Feb 13.

Research Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Background: The relation between endogenous testosterone concentrations and myocardial mass and function remains incompletely understood.

Objectives: To determine the cross-sectional association between endogenous hormone levels with cardiac magnetic resonance measures of myocardial mass, structure, and function in community-dwelling men across a wide age range.

Methods: A total of 720 men from the Framingham Heart Study Offspring Cohort (age range 37-82, mean = 59. Read More

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http://dx.doi.org/10.1111/andr.12590DOI Listing
February 2019

Post-extubation continuous positive airway pressure improves oxygenation after pediatric laparoscopic surgery: A randomized controlled trial.

Acta Anaesthesiol Scand 2019 Feb 14. Epub 2019 Feb 14.

Anesthesia and Intensive Care Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Effects of intraoperative recruitment maneuvers (RMs) on oxygenation and pulmonary compliance are lost during recovery if high inspired oxygen and airway suctioning are used. We investigated the effect of post-extubation noninvasive CPAP mask application on the alveolar arterial oxygen difference [(A-a) DO ] after pediatric laparoscopic surgery.

Methods: Sixty patients (1-6 years) were randomly allocated to three groups of 20 patients, to receive zero end-expiratory pressure (ZEEP group), RM with decremental PEEP titration only (RM group), or followed with post-extubation CPAP for 5 minutes (RM-CPAP group). Read More

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http://dx.doi.org/10.1111/aas.13324DOI Listing
February 2019

Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.

Br J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Dorset County Hospital NHS Foundation Trust, Williams Avenue, Dorchester, Dorset, DT1 2JY.

Background And Purpose: Pulmonary arterial hypertension (PAH) is an incurable, incapacitating disorder resulting from increased pulmonary vascular resistance, pulmonary arterial remodeling and right ventricular failure. In pre-clinical models, combination of a phosphodiesterase 5 inhibitor (PDE5i) with a neprilysin inhibitor augments natriuretic peptide bioactivity, promotes cyclic GMP signaling, and reverses the structural and hemodynamic deficits that characterize PAH. Herein, we conducted a randomized, double-blind, placebo-controlled trial to assess the efficacy and safety of repurposing the neprilysin inhibitor, racecadotril, in PAH. Read More

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http://dx.doi.org/10.1111/bph.14621DOI Listing
February 2019

Prediction of sudden cardiac death in chronic heart failure patients with reduced ejection fraction by ADMIRE-HF risk score and early repolarization pattern.

J Nucl Cardiol 2019 Feb 13. Epub 2019 Feb 13.

Division of Cardiology, Osaka General Medical Center, 3-1-56, Mandai-Higashi, Sumiyoshi-ku, Osaka, 558-8558, Japan.

Background: AdreView myocardial imaging for risk evaluation in heart failure (ADMIRE-HF) risk score is a novel risk score to predict serious arrhythmic risk in chronic heart failure patients with reduced ejection fraction (HFrEF). Moreover, early repolarization pattern (ERP) has been shown to be associated with an increased risk of sudden cardiac death (SCD) in HFrEF patients. We sought to investigate the prognostic value of combining ADMIRE-HF risk score and ERP to predict SCD in HFrEF patients. Read More

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http://dx.doi.org/10.1007/s12350-019-01639-6DOI Listing
February 2019

Discovery of Pathologic GPCR Aggregation.

Front Med (Lausanne) 2019 30;6. Epub 2019 Jan 30.

Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.

The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers. Read More

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http://dx.doi.org/10.3389/fmed.2019.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363654PMC
January 2019

Comparing the Changes in Blood Pressure After Acute Exposure to Tai Chi and Walking.

Int J Exerc Sci 2019 1;12(3):77-87. Epub 2019 Jan 1.

Department of Exercise Science and Sport Studies, Springfield College, Springfield, MA, USA.

Hypertension is a major health concern throughout the United States and is a major cause of cardiovascular disease. The purpose of this study was to compare the responses of Tai Chi and walking on measures of central and peripheral cardiac mechanisms when controlling for exercise intensity. Fifteen hypertensive subjects (2 males, 13 females; age = 20. Read More

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January 2019

Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures.

Front Immunol 2019 29;10:60. Epub 2019 Jan 29.

Virologie et Pathologie Humaine-VirPath Team, Centre International de Recherche en Infectiologie, INSERM U1111, CNRS UMR5308, ENS Lyon, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.

Influenza virus infections remain a major and recurrent public health burden. The intrinsic ever-evolving nature of this virus, the suboptimal efficacy of current influenza inactivated vaccines, as well as the emergence of resistance against a limited antiviral arsenal, highlight the critical need for novel therapeutic approaches. In this context, the aim of this study was to develop and validate an innovative strategy for drug repurposing as host-targeted inhibitors of influenza viruses and the rapid evaluation of the most promising candidates in Phase II clinical trials. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361841PMC
January 2019

Extracranial and Intracranial Vasculopathy With "Moyamoya Phenomenon" in Association With Alagille Syndrome.

Front Neurol 2018 29;9:1194. Epub 2019 Jan 29.

Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating The National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Alagille syndrome (AGS) is an autosomal-dominant, multisystem disorder caused by mutations in the JAG1 gene. A 34-year-old man was referred to our service 10 years ago with focal seizures with impaired awareness and transient slurred speech. He had a 5-year history of intermittent left monocular low-flow retinopathy. Read More

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http://dx.doi.org/10.3389/fneur.2018.01194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362309PMC
January 2019
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