588,564 results match your criteria High Blood Pressure & Cardiovascular Prevention[Journal]


Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.

Fetal Diagn Ther 2019 Apr 23:1-10. Epub 2019 Apr 23.

Implantation and Placental Development Laboratory, Centre for Reproductive Health, Hudson Institute of Medical Research, Clayton, Victoria, Australia,

Objective: The aim of this study was to investigate the potential utility of serum HtrA1 and HtrA3, serine proteases that are highly expressed in the developing placenta, at 15 and 20 weeks of gestation for predicting later development of adverse pregnancy outcomes of preeclampsia (PE), gestational hypertension (GHT), preterm birth (PTB), and small for gestational age (SGA) birth.

Methods: This is a nested case control study of 665 samples (330 controls, 335 cases) from the Adelaide SCOPE cohort. The cases included were 92 PE, 71 GHT, 56 PTB, and 116 SGA. Read More

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http://dx.doi.org/10.1159/000497144DOI Listing

Patient-Reported Experiences in Discussing Prescribed Medications with a Health Care Provider: Evidence for Racial/Ethnic Disparities in a Large Health Care Delivery System.

Popul Health Manag 2019 Apr 23. Epub 2019 Apr 23.

1 Palo Alto Medical Foundation Research Institute, Sutter Health, Palo Alto, California.

The objective was to understand patient-reported experiences in communicating with a health care provider about prescribed medications in a health care setting serving diverse racial/ethnic groups. Adult patients who completed a patient-experience survey and received a prescription for a hypertension, hyperlipidemia, or diabetes medication at the surveyed encounter were studied (N = 19,006). Data were collected in a large mixed-payer outpatient health care system in northern California between 2011 and 2014. Read More

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https://www.liebertpub.com/doi/10.1089/pop.2018.0206
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http://dx.doi.org/10.1089/pop.2018.0206DOI Listing
April 2019
1 Read

Hypertension Contributes to Neuropathy in Patients with Type 1 Diabetes.

Am J Hypertens 2019 Apr 23. Epub 2019 Apr 23.

Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.

Background: Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with T1DM. Read More

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http://dx.doi.org/10.1093/ajh/hpz058DOI Listing

The association between neck adiposity and long-term outcome.

PLoS One 2019 23;14(4):e0215538. Epub 2019 Apr 23.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Anthropometric indices of obesity (e.g. body mass index, waist circumference and neck circumference) are associated with poor long-term cardiovascular outcome. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215538PLOS

Critical role of Interleukin 21 and T follicular helper cells in hypertension and vascular dysfunction.

JCI Insight 2019 Apr 23;5. Epub 2019 Apr 23.

T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce interleukin 21 (IL21) promote germinal center (GC) B cell responses leading to immunoglobulin (Ig) production. Here we investigate the role of IL21 and Tfh cells in hypertension. Read More

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http://dx.doi.org/10.1172/jci.insight.129278DOI Listing

Opening Pandora's Box - Presumed ST Segment Elevation Myocardial Infarction with Symptomatic Ventricular Tachycardia is Cured by Resection of a Huge Left Ventricular Aneurysm.

Heart Surg Forum 2019 Apr 16;22(2):E170-E171. Epub 2019 Apr 16.

Cardioangiologisches Centrum Bethanien (CCB), Frankfurt am Main, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany.

A 76-year-old male patient with history of hypertension, type 2 diabetes, and smoking was admitted to the emergency department with chest pain. The patient reported severe and sudden chest pain accompanied by cold sweating, dizziness, and palpitations. Read More

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http://dx.doi.org/10.1532/hsf.2287DOI Listing

FATTY KIDNEY DISEASE: A NEW RENAL AND ENDOCRINE CLINICAL ENTITY? DESCRIBING THE ROLE OF THE KIDNEY IN OBESITY, METABOLIC SYNDROME AND TYPE 2 DIABETES.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

Both authors have no conflicts of interest for this manuscript and contributed equally to its writing.

Objective: To determine whether fatty kidney disease deserves be designated as a distinct clinical entity similar to fatty liver disease.

Methods: Analysis and interpretation of the literature in a novel conceptual framework.

Results: The kidney contributes to hyperglycemia, hypertension, inflammatory cytokines, and thus to diabetes and metabolic syndrome. Read More

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http://journals.aace.com/doi/10.4158/EP-2018-0568
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http://dx.doi.org/10.4158/EP-2018-0568DOI Listing

ASSOCIATIONS BETWEEN VITAMIN D AND MICROVASCULAR COMPLICATIONS IN MIDDLE-AGED AND ELDERLY DIABETIC PATIENTS.

Endocr Pract 2019 Apr 23. Epub 2019 Apr 23.

From: Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The objective of the cross-sectional study was to investigate the association of serum 25-hydroxyvitamin D [25(OH)D] levels with estimated glomerular filtration rate (eGFR), albuminuria/creatinine ratio (ACR) and the prevalence of diabetic retinopathy (DR) in Chinese diabetic adults. 4,767 diabetic participants were enrolled from seven communities in Shanghai, China in 2018. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, glucose, lipid profiles, 25(OH)D and ACR. Read More

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http://dx.doi.org/10.4158/EP-2019-0015DOI Listing

A Noninvasive, Economical, and Instant-Result Method to Diagnose and Monitor Type 2 Diabetes Using Pulse Wave: Case-Control Study.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e11959. Epub 2019 Apr 23.

Shanghai Key Laboratory of Health Identification and Assessment/Laboratory of Traditional Chinese Medicine Four Diagnostic Information, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: We should pay more attention to the long-term monitoring and early warning of type 2 diabetes and its complications. The traditional blood glucose tests are traumatic and cannot effectively monitor the development of diabetic complications. The development of mobile health is changing rapidly. Read More

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http://dx.doi.org/10.2196/11959DOI Listing

Image-Based Mobile System for Dietary Management in an American Cardiology Population: Pilot Randomized Controlled Trial to Assess the Efficacy of Dietary Coaching Delivered via a Smartphone App Versus Traditional Counseling.

JMIR Mhealth Uhealth 2019 Apr 23;7(4):e10755. Epub 2019 Apr 23.

Department of Medicine, School of Medicine & Health Sciences, The George Washington University, Washington, DC, United States.

Background: Randomized controlled trials conducted in Mediterranean countries have shown that the Mediterranean diet lowers adverse cardiovascular events. In the American population, diet remains the biggest uncontrolled risk factor for cardiovascular disease.

Objective: This study aimed to test the hypothesis that asynchronous dietary counseling supplied through a custom smartphone app results in better adherence to a Mediterranean diet in a non-Mediterranean population than traditional standard-of-care (SOC) counseling. Read More

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http://dx.doi.org/10.2196/10755DOI Listing

Association between pulse pressure at discharge and clinical outcomes in patients with acute myocardial infarction: From the KAMIR-Korean-NIH registry.

J Clin Hypertens (Greenwich) 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine, Haeundae Paik hospital, InJe University College of Medicine, Busan, Republic of Korea.

Pulse pressure (PP) is affected by arterial stiffness and is a predictor of cardiovascular events. However, value and utility of PP assessment in patients with acute myocardial infarction (AMI) remain less clear. We aimed to evaluate the association between PP and cardiovascular events in surviving patients with AMI at discharge. Read More

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http://dx.doi.org/10.1111/jch.13534DOI Listing

Time for Reform in Transplant Program Specific Reporting - AST/ASTS Transplant Metrics Taskforce.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Division of Transplantation, University of Minnesota, Minneapolis, Minnesota.

In accordance with the National Organ Transplant Act and HHS's Final Rule, the Scientific Registry of Transplant Recipients (SRTR) publicly releases biannual program-specific reports which include analyses of transplant centers' risk-adjusted wait-list mortality, organ acceptance ratios, transplant rates, and graft and patient survival. Since the inception of these center metrics, one-year post-transplant graft and patient survival have improved, and center variation has decreased, casting uncertainty on their clinical relevance. The SRTR has recently modified center evaluations by ranking centers into 5 tiers rather than 3-tiers in an attempt to discriminate between programs performing within a tight range, further exacerbating this uncertainty. Read More

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http://dx.doi.org/10.1111/ajt.15394DOI Listing

Opposite alterations of endothelin-1 in lung and pulmonary artery mirror gene expression of bone morphogenetic protein receptor 2 in experimental pulmonary hypertension.

Exp Lung Res 2019 Apr 23:1-12. Epub 2019 Apr 23.

a Department of Pharmacology and Toxicology, Faculty of Pharmacy , Comenius University in Bratislava , Bratislava , Slovakia.

Aim Of The Study: Endothelin-1 (ET-1) overexpression was suggested to play a role in pulmonary hypertension (PH). However, the roles of ET-1 in early stages of PH remain unexplored. We examined the expression of ET-1 and relevant disease progression markers in the pulmonary artery and the lungs during the development of PH induced by monocrotaline (MCT). Read More

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https://www.tandfonline.com/doi/full/10.1080/01902148.2019.1
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http://dx.doi.org/10.1080/01902148.2019.1605426DOI Listing
April 2019
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Abnormal Metabolic Phenotypes Among Urban Chinese Children: Epidemiology and the Impact of DXA-Measured Body Composition.

Obesity (Silver Spring) 2019 May;27(5):837-844

Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China.

Objective: This study aimed to describe the prevalence rates of abnormal metabolic phenotypes among urban Chinese children and to explore the impact of body composition as measured by dual-energy x-ray absorptiometry (DXA) on metabolic disorders.

Methods: A total of 7,926 children aged 6 to 17 years from seven cities across China were involved. Metabolically unhealthy was defined as having ≥ 2 risk factors (elevated blood pressure, high triglyceride levels, low levels of high-density lipoprotein cholesterol, and impaired fasting glucose [IFG]). Read More

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http://dx.doi.org/10.1002/oby.22426DOI Listing

7th World Congress on Controversies to Consensus in Diabetes, Obesity, and Hypertension.

J Diabetes 2019 Apr 22. Epub 2019 Apr 22.

Close Concerns, San Francisco, California, USA.

No abstract is available for this article. This article is protected by copyright. All rights reserved. Read More

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http://dx.doi.org/10.1111/1753-0407.12936DOI Listing

Coronary microvascular dysfunction is associated with cardiac time intervals in women with angina and no obstructive coronary artery disease: An iPOWER substudy.

Echocardiography 2019 Apr 22. Epub 2019 Apr 22.

Department of Cardiology, Bispebjerg University Hospital, Copenhagen, Denmark.

Background: Coronary microvascular dysfunction (CMD) may cause angina in the absence of obstructive coronary artery disease (CAD) and increases the risk of future adverse cardiovascular events. Transthoracic Doppler echocardiography (TTDE) with pharmacological stress can assess coronary flow velocity reserve (CFVR), a measure of coronary microvascular function. However, simpler methods would be preferable for diagnosing CMD. Read More

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http://dx.doi.org/10.1111/echo.14356DOI Listing

POEMS Syndrome: update on diagnosis, risk-stratification, and management.

Am J Hematol 2019 Apr 22. Epub 2019 Apr 22.

Professor of Medicine and Laboratory Medicine, Mayo Clnic.

Disease Overview: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis. Read More

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http://dx.doi.org/10.1002/ajh.25495DOI Listing

Low dose 100 cGy irradiation as a potential therapy for pulmonary hypertension.

J Cell Physiol 2019 Apr 22. Epub 2019 Apr 22.

Division of Hematology/Oncology, Department of Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Pulmonary hypertension (PH) is an incurable disease characterized by pulmonary vascular remodeling and ultimately death. Two rodent models of PH include treatment with monocrotaline or exposure to a vascular endothelial growth factor receptor inhibitor and hypoxia. Studies in these models indicated that damaged lung cells evolve extracellular vesicles which induce production of progenitors that travel back to the lung and induce PH. Read More

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http://dx.doi.org/10.1002/jcp.28723DOI Listing

Pentosidine in chronic hemodialysis patients: relation with arteriovenous fistula morphology and function.

Int Urol Nephrol 2019 Apr 22. Epub 2019 Apr 22.

Department of Nephrology, "Iuliu Haţieganu" University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania.

Purpose: It has been suggested that advanced glycation end products (AGEs) are involved in atherogenesis, vascular calcification and remodeling, including neointimal hyperplasia, in renal and non-renal patients. Their relevance for arteriovenous fistula (AVF) function has been poorly studied to date, with only one clinical study addressing the issue of thrombosis of vascular access in relation to AGEs in dialysis patients. We aimed to evaluate the relationship between serum pentosidine and AVF morphology and function. Read More

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http://dx.doi.org/10.1007/s11255-019-02151-zDOI Listing

Lifestyle Interventions to Prevent Cardiovascular Events After Stroke and Transient Ischemic Attack.

Curr Cardiol Rep 2019 Apr 22;21(6):44. Epub 2019 Apr 22.

Paul L. Foster School of Medicine, Department of Neurology, Texas Tech University Health Sciences Center El Paso, El Paso, TX, 79905, USA.

Purpose Of Review: To summarize lifestyle interventions including pharmacological and non-pharmacological methods targeting modifiable risk factors and their impact on the future cardiovascular events in patients who have suffered transient ischemic attack (TIA) and/or ischemic stroke (IS).

Recent Findings: The latest research indicates that secondary prevention measures can decrease the risk of recurrent stroke, cardiovascular events, and even death. Modifiable risk factors also require behavioral change which can be challenging. Read More

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http://link.springer.com/10.1007/s11886-019-1132-x
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http://dx.doi.org/10.1007/s11886-019-1132-xDOI Listing
April 2019
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How Digital Health Can Be Applied for Preventing and Managing Hypertension.

Curr Hypertens Rep 2019 Apr 22;21(5):40. Epub 2019 Apr 22.

Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.

Purpose Of Review: To summarize available data on digital health strategies for the prevention and management of hypertension, discussing the state-of-the-art, current limitations, and future perspective of this approach.

Recent Findings: Technology is developing at a fast pace and is providing a number of novel solutions for cardiovascular patients, in particular in the field of digital health. Even if the benefit of these approaches is intuitive, the methodological heterogeneity of the available studies and their small sample size have made it difficult to provide robust evidence regarding the usefulness and cost-effectiveness of digital health technologies. Read More

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http://dx.doi.org/10.1007/s11906-019-0940-0DOI Listing

Secondary Headaches During Pregnancy: When to Worry.

Curr Neurol Neurosci Rep 2019 Apr 22;19(6):27. Epub 2019 Apr 22.

Women's College Hospital Centre for Headache, Division of Neurology, University of Toronto, 76 Grenville St., Toronto, Ontario, M5S 1B2, Canada.

Purpose Of Review: Headaches in pregnancy are a frequent cause of worry for both patients and healthcare providers. Physiological changes during this period increase the risk of a number of secondary headache disorders, and often also have an impact on primary headache disorders. This article reviews recent research into distinguishing worrisome vs non-worrisome headache presentations during pregnancy. Read More

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http://dx.doi.org/10.1007/s11910-019-0944-9DOI Listing

Safe coordinated trafficking of heme and iron with copper maintain cell homeostasis: modules from the hemopexin system.

Biometals 2019 Apr 22. Epub 2019 Apr 22.

School of Biological Sciences, University of Missouri, Kansas, USA.

Studies with patients, animal models of human disease and hemopexin null mice have shown that the heme-binding protein hemopexin is vital for the protection of a variety of cell types and tissues against heme toxicity. The presence of hemopexin in all biological fluids examined to date indicates wide roles in abrogating heme toxicity in human tissues; and, thus, is clinically relevant. Heme-hemopexin endocytosis leads to coordinated trafficking of heme, iron and copper as heme traffics from endosomes to heme oxygenases (HOs) in the smooth endoplasmic reticulum and to the nucleus. Read More

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http://dx.doi.org/10.1007/s10534-019-00194-4DOI Listing

Effects of decompressive operation on cardiac autonomic regulation in patients with cervical spondylotic myelopathy: analysis of blood pressure, heart rate, and heart rate variability.

Eur Spine J 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan Province, People's Republic of China.

Purpose: To investigate the effects of cervical decompression operation on cardiac autonomic regulation and its relationship to recovery of somatic neurological function in cervical spondylotic myelopathy (CSM) patients.

Methods: One hundred and thirty-two consecutive patients were enrolled in this study, in which 73 patients received decompression operation and the remaining 59 were treated non-operatively. The follow-up period was 6 months. Read More

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http://dx.doi.org/10.1007/s00586-019-05972-9DOI Listing

Liver stiffness and thrombin generation in compensated cirrhosis.

Res Pract Thromb Haemost 2019 Apr 28;3(2):291-297. Epub 2019 Jan 28.

Department of Hepatology Mater Misericordiae University Hospital Dublin Ireland.

Background: Decompensated cirrhosis is associated with coagulation abnormalities that can increase the risk of thrombosis and bleeding. It is unclear precisely when these abnormalities arise and whether they are exacerbated as compensated cirrhosis progresses. Transient elastography using FibroScan generates liver stiffness measurements (LSM) that associate with portal hypertension, clinical outcomes and provides prognostic information at an earlier stage than traditional liver function scores eg, MELD score. Read More

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http://dx.doi.org/10.1002/rth2.12173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462746PMC

Evaluation of Vascular Event Risk while on Long-term Anti-retroviral Suppressive Therapy [EVERLAST]: Protocol for a prospective observational study.

eNeurologicalSci 2019 Jun 5;15:100189. Epub 2019 Apr 5.

Department of Neurology, University of California, San Francisco, USA.

Background & Objective: Cardiovascular disease (CVD) risk among the HIV population is high due to a combination of accelerated atherosclerosis from the pro-inflammatory milieu created by chronic HIV infection and the potentially adverse metabolic side effects from cART (combination antiretroviral therapy) medications. Although sub-Saharan Africa (SSA) bears 70% of the global burden of HIV disease, there is a relative paucity of studies comprehensively assessing CVD risk among people living with HIV on the continent. The overarching objective of the Evaluation of Vascular Event Risk while on Long-term Anti-retroviral Suppressive Therapy (EVERLAST) Study is to characterize the burden of CVD among HIV patients on ART in Ghana, and explore factors influencing it. Read More

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http://dx.doi.org/10.1016/j.ensci.2019.100189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460293PMC

A minimum of two years of undertreated primary hypothyroidism, as a result of drug-induced malabsorption of l-thyroxine, may have metabolic and cardiovascular consequences.

J Clin Transl Endocrinol 2019 Jun 10;16:100189. Epub 2019 Apr 10.

Medico di Medicina Generale, ASP 5, Messina, Italy.

Objective: Cross-sectional studies have reported that TSH above or close to the upper normal limit correlates with unfavorable metabolic and cardiovascular outcomes. Certain medications impair intestinal absorption of levothyroxine (L-T4), resulting in undertreated hypothyroidism (. failure of serum TSH to reach target levels, if hypothyroidism is primary). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22146237193002
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http://dx.doi.org/10.1016/j.jcte.2019.100189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462542PMC

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.

Aging Dis 2019 Apr 1;10(2):470-482. Epub 2019 Apr 1.

Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center College of Medicine, College Station, Texas, USA.

The mechanisms that underlie the pathophysiology of aging, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and stroke are not fully understood and have been the focus of intense and constant investigation worldwide. Studies that provide insights on aging and age-related disease mechanisms are critical for advancing novel therapies that promote successful aging and prevent or cure multiple age-related diseases. The April 2019 issue of the journal, "Aging & Disease" published a series of articles that confer fresh insights on numerous age-related conditions and diseases. Read More

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http://dx.doi.org/10.14336/AD.2019.0330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457051PMC

Involvement of the MiR-181b-5p/HMGB1 Pathway in Ang II-induced Phenotypic Transformation of Smooth Muscle Cells in Hypertension.

Aging Dis 2019 Apr 1;10(2):231-248. Epub 2019 Apr 1.

1Department of Cardiovascular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.

Phenotypic transformation of vascular smooth muscle cells (VSMCs) contributes to vascular remodeling in hypertension. High mobility group box-1 (HMGB1) has been reported to be involved in several pathogenic processes including VSMC proliferation and migration. The present study was designed to determine the role of HMGB1 in VSMC phenotypic transformation in hypertension. Read More

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http://dx.doi.org/10.14336/AD.2018.0510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457049PMC

[Hydrocephaly resulting from thrombophlebitis of the superior sagittal sinus due to osteitis of the cranial vault caused by Aspergillus fumigatus in an immunocompetent patient].

Pan Afr Med J 2018 9;31:97. Epub 2018 Oct 9.

Service de Neurochirurgie CHU Yopougon, Abidjan, Côte d'Ivoire.

This case study presents an unusual pathogenic association among several cranioencephalic lesions characterized by the association of osteitis of the cranial vault, due to Aspergillus fumigatus, with underlying thrombophlebitis complicated by intracranial hypertension resulting from hydrocephalus. The study involved a 43-year old HIV (human immunodeficiency virus) negative man with multi-recurrent infection of the frontal scalp. The patient was successfully treated with cerebrospinal fluid diversion (CFD), Ketoconazole and low molecular weight heparin. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.97.14251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462154PMC
October 2018

Developmental venous anomaly (DVA) mimicking thrombosed cerebral vein.

Radiol Case Rep 2019 Jun 10;14(6):778-781. Epub 2019 Apr 10.

Department of Radiology, Alnoor Specialist Hospital, Makkah, Saudi Arabia.

Venous angiomas are relatively common lesions that occur in up to 3% of the general population. It is usually asymptomatic and discovered incidentally. We present a case of developmental venous anomaly mimicking thrombosed cerebral vein on nonenhanced computed tomography scan of the brain. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461576PMC

Treatment of Portopulmonary Hypertension With Macitentan in Patients With Cirrhosis.

Authors:
Michael J Krowka

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):108-110

Professor of Medicine Consultant, Division of Gastroenterology/Hepatology and Division of Pulmonary/Critical Care Medicine Mayo Clinic Rochester, Minnesota.

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February 2019

Congenital Cardiovascular Anomalies among Cases of Down Syndrome: A Hospital Based Review of Cases in TikurAnbessa Specialized Hospital, Ethiopia.

Ethiop J Health Sci 2019 Mar;29(2):165-174

Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa University, Ethiopia.

Background: In developing countries, infants with Down syndrome and cardiac defect are at increased risk of dying. Congenital heart diseases occur in 40-50% of affected infants. Endocardial cushion defect accounts for the most. Read More

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http://dx.doi.org/10.4314/ejhs.v29i2.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460451PMC
March 2019
1 Read

A signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes.

Nat Med 2019 Apr 22. Epub 2019 Apr 22.

Research Division, Joslin Diabetes Center, Boston, MA, USA.

Chronic inflammation is postulated to be involved in the development of end-stage renal disease in diabetes, but which specific circulating inflammatory proteins contribute to this risk remain unknown. To study this, we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with type 1 and type 2 diabetes. In each cohort, we identified an extremely robust kidney risk inflammatory signature (KRIS), consisting of 17 proteins enriched in tumor necrosis factor-receptor superfamily members, that was associated with a 10-year risk of end-stage renal disease. Read More

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http://dx.doi.org/10.1038/s41591-019-0415-5DOI Listing

Status of Hypertension in Tehran: Potential impact of the ACC/AHA 2017 and JNC7 Guidelines, 2012-2015.

Sci Rep 2019 Apr 23;9(1):6382. Epub 2019 Apr 23.

Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

This study aimed to determine the prevalence of hypertension, the recommended anti-hypertensive therapy and the percentage of hypertensive patients who had achieved the blood pressure (BP) target according to 2017 American College of Cardiology/American Heart Association (ACC/AHA) versus JNC7 and 8 guidelines, among Iranian population. Data of participants aged ≥20 years from the fifth phase (2012-2015) of the Tehran lipid and glucose study (N = 10,576) were analyzed, using survey analysis. The weighted prevalence of hypertension among those not on anti-hypertensive medications was 42. Read More

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http://www.nature.com/articles/s41598-019-42809-3
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http://dx.doi.org/10.1038/s41598-019-42809-3DOI Listing
April 2019
1 Read

High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan.

Diabetes Care 2019 May;42(5):938-945

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Objective: To investigate the prevalence and causes of diabetes in patients with primary aldosteronism (PA) in a multi-institutional cohort study in Japan.

Research Design And Methods: The prevalence of diabetes was determined in 2,210 patients with PA (diagnosed or glycated hemoglobin [HbA] ≥6.5% [≥48 mmol/mol]; NGSP) and compared with that of the Japanese general population according to age and sex. Read More

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http://dx.doi.org/10.2337/dc18-1293DOI Listing

Mutation-specific Fabry disease patient-derived cell model to evaluate the amenability to chaperone therapy.

J Med Genet 2019 Apr 22. Epub 2019 Apr 22.

Internal Medicine D, Department of Nephrology, Hypertension and Rheumatology, University Hospital Muenster, Muenster, Germany.

Background: Patients with Fabry disease (FD) and amenable mutations can be treated with the chaperone migalastat to restore endogenous α-galactosidase A (AGAL) activity. However, certain amenable mutations do not respond biochemically in vivo as expected. Here, we aimed to establish a patient-specific and mutation-specific cell model to evaluate the amenability to chaperone therapy in FD. Read More

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http://dx.doi.org/10.1136/jmedgenet-2019-106005DOI Listing

Arteriovenous fistulae for access to hemodialysis in Chad : feasibility study of a medical civic action program by a French army surgical unit.

Med Sante Trop 2019 Apr 23. Epub 2019 Apr 23.

HIA Sainte-Anne, 83800 Toulon, France.

Introduction: Use of chronic intermittent hemodialysis is recent in Chad, where it remains underdeveloped. Vascular access is most commonly by catheter. The objective of our study was to demonstrate the feasibility of arteriovenous fistula (AVF) surgery for hemodialysis during deployments as part of the medical civic action program (MEDCAP). Read More

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http://dx.doi.org/10.1684/mst.2018.0858DOI Listing

Dietary Modification Is Associated with Normalization of Penile Hemodynamics in Rats Fed a High-Fat Diet.

J Sex Med 2019 Apr 19. Epub 2019 Apr 19.

Division of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Diet is associated with self-reported indices of sexual health. The mechanisms responsible for these changes remain poorly understood.

Aim: To investigate the hemodynamic and histological impact of dietary change in a rat model of hyperlipidemia-associated erectile dysfunction. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.03.013DOI Listing

[New insights in the pathogenesis of pulmonary arterial hypertension].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Inserm UMR_S 999, hôpital Marie Lannelongue, 133, avenue de la Résistance, 92350 Le Plessis-Robinson, France; Faculté de Médecine, université Paris-Sud, université Paris-Saclay, 94270 Le Kremlin-Bicêtre, France. Electronic address:

Pulmonary arterial hypertension (PAH) is a severe and incurable cardiopulmonary disorder. Research from the past 10 years illustrates the complex and multifactorial aspects of PAH pathophysiology. Furthermore, latest advances in the field have led to a better understanding of the key components underlying this inadequate accumulation of pulmonary vascular cells within the pulmonary arterial walls, leading to pulmonary vascular remodelling. Read More

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http://dx.doi.org/10.1016/j.rmr.2019.03.003DOI Listing

Portal Vein Stent Placement in Living-donor Liver Transplantation: A Single-center Experience.

Transplant Proc 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Introduction: Portal vein thrombosis (PVT) and portal vein stenosis (PVS) are rare complications after liver transplantation that can lead to graft failure and patient death.

Material And Methods: The aim of this study was to evaluate the effect of interventional treatment for PVT and PVS occlusion after liver transplantation. Follow-up data of 7 patients who underwent stent replacement for PVT and/or PVS were analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183170
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http://dx.doi.org/10.1016/j.transproceed.2019.01.123DOI Listing
April 2019
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Vascular Access Choice, Complications, and Outcomes in Children on Maintenance Hemodialysis: Findings From the International Pediatric Hemodialysis Network (IPHN) Registry.

Am J Kidney Dis 2019 Apr 19. Epub 2019 Apr 19.

Center for Pediatrics and Adolescent Medicine, Heidelberg, Germany. Electronic address:

Rationale & Objective: Arteriovenous fistulas (AVFs) have been recommended as the preferred vascular access for pediatric patients on maintenance hemodialysis (HD), but data comparing AVFs with other access types are scant. We studied vascular access choice, placement, complications, and outcomes in children.

Study Design: Prospective observational cohort study. Read More

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http://dx.doi.org/10.1053/j.ajkd.2019.02.014DOI Listing

Treatment and Prevention of Hypertensive Disorders During Pregnancy.

Clin Perinatol 2019 Jun 30;46(2):173-185. Epub 2019 Mar 30.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of South Florida, Morsani College of Medicine, 2 Tampa General Circle, 6th Floor, Tampa, FL 33606, USA.

This article reviews the pharmacology of the most commonly used antihypertensive medications during pregnancy; their mechanism of action; and the effects on the mother, the fetus, and lactation. Each class of antihypertensive pharmacologic agents have specific mechanisms of action by which they exert their antihypertensive effect. β-Adrenoreceptor antagonists block these receptors in the peripheral circulation. Read More

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http://dx.doi.org/10.1016/j.clp.2019.02.002DOI Listing

Association between the choice of anesthesia and in-hospital outcomes after carotid artery stenting.

J Vasc Surg 2019 May;69(5):1461-1470.e4

Johns Hopkins Bayview Vascular and Endovascular Research Center, Baltimore, Md. Electronic address:

Objective: Several prior studies have shown lower risk of myocardial infarction (MI) in carotid artery stenting (CAS) compared with carotid endarterectomy. This is likely because the majority of endarterectomies are performed under general anesthesia (GA), whereas CAS is mainly performed under local anesthesia (LA). Performing CAS under GA may reverse its minimally invasive benefits. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.07.064DOI Listing

Male PCOS equivalent and nutritional restriction: Are we stepping forward?

Med Hypotheses 2019 May 5;126:1-3. Epub 2019 Mar 5.

Department of Medical Surgical Specialties, University of Catania, Via Tindaro 2, 95124 Catania, Italy.

Polycystic ovarian syndrome (PCOS) is an endocrine disorder characterized by alteration of menses, polycystic ovaries, clinical and or biochemical signs of hyper-androgenism in the context of metabolic abnormalities such as obesity and insulin resistance that play a fundamental role in pathogenesis of the disease as well as in development of long-term complications including cardiovascular disease (CVD) and type II diabetes mellitus (DM II). Latest evidence supports the hypothesis of a genetic component in the aetiology of PCOS that seems to be inherited through an oligo-genic mechanism and cluster in families. Recent studies identified the existence of a male PCOS correspondent syndrome in which the genes responsible for PCOS susceptibility in women may be inherited by male relatives of women with PCOS. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.003DOI Listing

Disseminated toxoplasmosis: a life-threatening complication of inadequate posttransplant prophylaxis.

Kidney Int 2019 May;95(5):1274

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1016/j.kint.2018.10.002DOI Listing

Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.

Kidney Int 2019 May;95(5):1027-1036

KfH Kidney Center, Munich, Germany; Department of Nephrology and Hypertension, University Hospital, Friedrich-Alexander University, Erlangen-Nuremberg, Germany. Electronic address:

In September 2017, KDIGO (Kidney Disease: Improving Global Outcomes) convened a Controversies Conference titled Blood Pressure in Chronic Kidney Disease (CKD). The purpose of the meeting was to consider which recommendations from the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKD should be reevaluated based on new evidence from clinical trials. Participants included a multidisciplinary panel of clinical and scientific experts. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.025DOI Listing

Frequency of fragmented QRS in patients with hypertension.

Blood Press 2019 Apr 23. Epub 2019 Apr 23.

a Department of Cardiology, Faculty of Medicine , Harran University , Sanliurfa , Turkey.

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http://dx.doi.org/10.1080/08037051.2019.1604065DOI Listing

Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619840375

1 MedStar Washington Hospital Center, Washington, DC, USA.

Pulmonary veno-occlusive disease (PVOD) is a rare entity that is usually mistaken with pulmonary arterial hypertension (PAH) but is considered class I' of PAH. It is important to subclassify PVOD and distinguish it from PAH as treatment with vasodilators in PVOD patients is controversial and may be fatal. In this article, we describe a case of PVOD and how we diagnosed it. Read More

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http://dx.doi.org/10.1177/2324709619840375DOI Listing

The Keeping on Track Study: Exploring the Activity Levels and Utilization of Healthcare Services of Acute Coronary Syndrome (ACS) Patients in the First 30-Days after Discharge from Hospital.

Med Sci (Basel) 2019 Apr 19;7(4). Epub 2019 Apr 19.

Monash University, Clayton, Victoria 3168, Australia.

The aim of this study was to investigate the impact of bedside discharge education on activity levels and healthcare utilization for patients with acute coronary syndrome (ACS) in the first 30 days post-discharge. Knowledge recall and objective activity and location data were collected by global positioning systems (GPS). Participants were asked to carry the tracking applications (apps) for 30⁻90 days. Read More

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http://dx.doi.org/10.3390/medsci7040061DOI Listing
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