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Orv Hetil 2019 Feb;160(8):291-299

Bőr-, Nemikórtani és Bőronkológiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Mária u. 41., 1085.

Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicles, usually presenting after puberty on the apocrine gland-bearing areas of the body. It usually flares up periodically and can lead to a severe condition affecting the 20-40-year-old childbearing age group. HS occurs more commonly in women. Read More

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.

We thank R. Happle for his invaluable comments on our recent article regarding the prevalence of hidradenitis suppurativa (HS) in Korea. We agree with the opinion that the low prevalence of HS in Korean women may be due to the low number of female smokers in Korea. Read More

J Eur Acad Dermatol Venereol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Medical Center - University of Freiburg, Germany.

In a recent population-based study on hidradenitis suppurativa (HS) in Korea, Lee et al. found that the female to male ratio was 1:1.6. Read More

Eur J Dermatol 2019 Feb 11. Epub 2019 Feb 11.

CHRU Tours, Department of Dermatology, 37044 Tours,, Universities of Tours and Nantes, SPHERE-INSERM 1246.

JAAD Case Rep 2019 Feb 30;5(2):184-187. Epub 2019 Jan 30.

Departments of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy.

J Am Acad Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell. New Hyde Park, NY, USA. Electronic address:

Background: Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) are reported to coexist, although prevalence of PG among HS patients has not been systematically evaluated.

Objective: To evaluate PG prevalence among HS patients.

Methods: Cross-sectional analysis of adults with PG among HS and non-HS patients using electronic health records data from a population-based sample of 55 million patients. Read More

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

Clin Exp Dermatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Dermatology, Royal North Shore Hospital, St Leonards, Sydney, Australia.

Background: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. There is also evolving evidence supporting the association between HS and cardiovascular risk factors, including smoking, obesity, hyperlipidaemia and metabolic syndrome. Notably, these are clinical features and risk factors that are closely associated with type 2 diabetes mellitus (DM). Read More

Dermatol Surg 2019 Feb;45(2):294-296

Department of Dermatology, Henry Ford Hospital System, Detroit, Michigan.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Zealand University Hospital, Roskilde, Health Sciences Faculty, University of Copenhagen, Denmark.

Background: Monitoring disease activity over time is a prerequisite for clinical practice and research. Valid and reliable outcome measurements instruments (OMIs) and staging systems provide researchers and clinicians with benchmark tools to assess the primary and secondary outcomes of interventional trials and to guide treatment selection properly.

Objectives: To investigate interrater reliability and agreement in instruments currently used in Hidradenitis Suppurativa (HS) with HS-experienced dermatologists being the rater population of interest. Read More

Exp Dermatol 2019 Feb;28 Suppl 2:5-55

Clin Exp Dermatol 2019 Feb 5. Epub 2019 Feb 5.

Department of Dermatology, Tallaght University Hospital, Tallaght, Dublin 24, Ireland.

We report eight cases of patients with severe acne who were treated with Isotretinoin and developed painful nodules in their axillae and groin consistent with Hidradenitis Suppurativa (HS). The pathogenesis of HS is still not completely understood; recent research from a study in 2011 of biopsies from HS lesions showed a reduction or absence of sebaceous glands compared to normal skin in HS patients and the author suggested this contributes to the pathogenesis of the disease Interestingly the main effect of Isotretinoin is to decrease the size and action of sebaceous glands; so hypothetically, as Isotretinoin acts by reducing the sebaceous glands further it could potentially aggravate the condition. Our experience has instilled caution in our prescribing of Isotretinoin; patients are questioned about symptoms of HS prior to and during treatment, particularly patients with acne conglobata. Read More

Immunotherapy 2019 Jan;11(1):45-59

Department of Dermatology, Venereology & Allergology, Medical University, Wroclaw, Poland.

Hidradenitis suppurativa (HS) is a chronic, inflammatory dermatosis characterized by an occurrence of nodules, abscesses, sinus tracks and scarring. Its pathogenesis is multifactorial and still not fully understood, therefore, current systemic therapies still remain a serious challenge. Increased levels of several proinflammatory cytokines have been reported in patients suffering from HS, therefore biologics appear as a new approach to therapy for this condition. Read More

JAMA Dermatol 2019 Jan 30. Epub 2019 Jan 30.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

Dermatol Ther 2019 Jan 28:e12841. Epub 2019 Jan 28.

Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

Hidradenitis suppurativa is a chronic skin disease with an intense inflammatory activation. It typically affects the intertriginous areas with cysts, fistulae, and scarring extremely painful. Patients suffer from severe psychological impact. Read More

Br J Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY.

Background: Genotype-phenotype correlation is a statistical relationship that measures correlation between the presence of a physical trait with a group of similar mutations but is dependent upon reliable phenotyping. It can provide information regarding disease pathogenesis, future disease progression, severity or activity. Such indicators would be valuable in Hidradenitis Suppurativa. Read More

Br J Dermatol 2019 Jan 28. Epub 2019 Jan 28.

Imperial College, London, United Kingdom.

Background: Human skin is populated by diverse bacteria and there is increasing evidence that resident bacteria play a key role initiating immune responses in cutaneous diseases such as atopic dermatitis, psoriasis and hidradenitis suppurativa. Bacteria are present at all layers of the skin but many studies have relied on swabs to profile the skin microbiota. As the pathogenesis of many skin conditions is dermal, we wished to compare the microbiota obtained in swabs (surface) and biopsies (dermis). Read More

Int J Surg Case Rep 2019 Jan 19;55:50-53. Epub 2019 Jan 19.

Department of Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, 14642-0001, USA.

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin that has potential for malignant transformation into squamous cell carcinoma (SCC). The pathogenesis of HS is poorly understood but thought to be from follicular keratinization, occlusion, and rupture of the pilosebaceous unit, followed by an infiltration of inflammatory cells into the dermis. Treatment is challenging due to a lack of effective medical therapies. Read More

Acta Derm Venereol 2019 01 23. Epub 2019 Jan 23.

Department of Dermatology, University Medical Center Groningen, NL-9700 RB Groningen, The Netherlands.

BMJ Case Rep 2019 Jan 20;12(1). Epub 2019 Jan 20.

Physical Medicine and Rehabilitation, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.

A 41-year-old obese Native American woman presented with hidradenitis suppurativa (HS) after failing all available treatment options. Her HS was more pronounced in the axillary and groin regions (Hurley stage III) and was a major source of her pain and a barrier for home exercise and aquatic therapy. She received a botulinum toxin A injection every 3 months (four times thus far), which has significantly helped alleviate her pain and curb the progress of her HS by resolving abscesses and healing draining sinuses. Read More

Acta Dermatovenerol Croat 2018 Dec;26(4):289-296

Iben Marie Miller, MD, Department of Dermatology, Roskilde Hospital, Køgevej 7-13, 4000 Roskilde, Denmark;

Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological disease with inflammatory mechanisms overlapping those of psoriasis, and both diseases have been associated with cardiovascular risk factors i.e. smoking and metabolic syndrome. Read More

J Cutan Med Surg 2019 Jan 18:1203475418823529. Epub 2019 Jan 18.

2 Division of Dermatology, Faculty of Medicine, University of Ottawa and The Ottawa Hospital, ON, Canada.

Background:: Although a variety of medical and surgical interventions exist for the treatment of hidradenitis suppurativa (HS), it remains a challenging disease to manage because of its variable presentation and unpredictable clinical course. Apart from the combination of clindamycin and rifampin, the success of other combination therapies is largely unknown.

Objectives:: The goal of our study was to examine the clinical utility of various combination therapies for the treatment of HS. Read More

Exp Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Departments of Dermatology University Hospital Zealand, Roskilde.

Background: The role of bacterial biofilm in hidradenitis suppurativa (HS) is highly debated. Less biofilm is found in clinically unaffected axillary perilesional skin of HS patients compared with healthy controls.

Objective: To study the correlation between biofilm and the phenotypical characterization of the pre-clinical inflammatory infiltrate. Read More

Br J Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany.

Hidradenitis Suppurativa (HS)/ acne inversa is defined as a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle that usually presents after puberty with painful, deep-seated, inflamed lesions in the apocrine gland-bearing areas of the body, most commonly the axillae, inguinal and anogenital regions (Dessau definition). It is associated with systemic comorbidities and influenced by genetic predisposition while triggering of the disease occurs by environmental factors. Consecutively, innate immune events appear to play a role. Read More

Br J Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Biologics targeting inflammatory mediators are able to clinically improve hidradenitis suppurativa (HS). However, their clinical efficacy shows great inter-patient variability in daily practice.

Objective: To investigate the anti-inflammatory potency of a selection of currently available biologics for the treatment of HS in an ex vivo skin culture system using lesional HS biopsies. Read More

Clin Exp Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Medicine, Division of Rheumatology, Washington University, St Louis, MO, USA.

Background: Hidradenitis suppurativa (HS), also called acne inversa, is a chronic skin disease. The symptoms can be severe, and include intensely painful nodules and abscesses in apocrine-gland rich inverse skin, such as the buttocks, under the arms and in the groin. Autosomal dominant forms of HS exist, but are rare. Read More

Dermatology 2019 Jan 16:1-6. Epub 2019 Jan 16.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany.

Background: A more reliable classification of skin inflammation and severity of active disease results from ultrasound sonography and the new hidradenitis suppurativa/acne inversa (HS) classification system IHS4. However, an objective assessment of skin inflammation in a continuous mode is still the ultimate goal. Long-wave medical infrared thermography (MIT) may offer a blood flow and temperature differential assessment in inflammatory conditions. Read More

Reumatologia 2018 23;56(6):337-339. Epub 2018 Dec 23.

Department of Dermatology, Medical Centre for Postgraduate Education, Central Hospital of Ministry of Internal Affairs, Warsaw, Poland.

Skin Appendage Disord 2018 Nov 11;5(1):38-41. Epub 2018 Apr 11.

Department of Dermatology, University of Pisa, Pisa, Italy.

Hidradenitis suppurativa (HS) is a chronic, burdensome inflammatory skin disorder mainly affecting adults with an infrequent onset during childhood or adolescence. Guidelines regarding the therapeutic drugs in pediatric HS patients are lacking. We describe the case of a 16-year-old girl affected by HS with a massive impact of the disease on her daily activities. Read More

G Ital Dermatol Venereol 2019 Jan 9. Epub 2019 Jan 9.

Dermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

J Eur Acad Dermatol Venereol 2019 Jan 11. Epub 2019 Jan 11.

Dipartimento di Medicina Clinica e Specialistica, U.O. di Dermatologia, A.O.U. di Ferrara, Ferrara, Italy.

Background: Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin disease characterized by painful inflamed nodules, recurrent abscesses, and fistulas located in apocrine gland-bearing body sites. The negative impact of HS on patient's quality of life (QoL) has been reported to be greater than other dermatologic conditions as psoriasis and atopic eczema, and its improvement is an important goal in disease management. Nowadays there are no specific validated QoL instruments available for HS and generic dermatologic questionnaires are used. Read More

J Am Acad Dermatol 2019 Jan 7. Epub 2019 Jan 7.

Department of Dermatology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

Int J Womens Dermatol 2018 Dec 11;4(4):198-202. Epub 2018 Oct 11.

Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.

Background: Hidradenitis suppurativa (HS) and psoriasis are inflammatory skin diseases associated with obesity. Each disease is likely to impact the quality of life of patients, but the relative impact of each disease is unknown.

Objectives: This study aimed to determine whether skin disease or obesity is more distressing to obese patients who have either psoriasis or HS. Read More

Dermatol Ther 2019 Jan 8:e12812. Epub 2019 Jan 8.

Department of Dermatology and Venerology, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkey.

Metabolic syndrome, a commonly observed pathology and a global health issue, is closely related to the skin and thus dermatologists. The skin contributes to the development of metabolic syndrome and it is an end organ for it. Metabolic dysfunction is related to many skin disorders, some of which with high association and some of which with lower association. Read More

Front Immunol 2018 14;9:2965. Epub 2018 Dec 14.

Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands.

The pathogenesis of hidradenitis suppurativa (HS) is not fully understood. This systematic review examined the latest evidence for molecular inflammatory pathways involved in HS as a chronic inflammatory skin disease. A systematic literature search was performed in PubMed/Medline and EMBASE from January 2013 through September 2017, according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA). Read More

Skin Res Technol 2019 Jan 4. Epub 2019 Jan 4.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Unità Operativa di Dermatologia, Università degli Studi di Milano, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy.

Dermatol Surg 2018 Dec 24. Epub 2018 Dec 24.

Departments of Dermatology.

Background: Few reports describe squamous cell carcinoma (SCC) arising in hidradenitis suppurativa (HS).

Objective: The 2 objectives were (1) to describe the clinical characteristics, pathologic findings, and postoperative outcomes of SCC in HS and (2) to assess whether human papillomavirus (HPV) is involved in the pathogenesis.

Materials And Methods: Cases of SCC in HS were identified through institutional medical records (1976-2013) and the Rochester Epidemiology Project. Read More

Br J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology und Allergy, Division of Evidence-Based Medicine (dEBM)Department of Dermatology, Charité, Berlin.

Br J Dermatol 2019 Jan 3. Epub 2019 Jan 3.

Dermatology Department, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Nutrients 2018 Dec 28;11(1). Epub 2018 Dec 28.

Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131 Naples, Italy.

Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating skin disorder. The exacerbating factors of HS include nutrition and adiposity. We aimed to investigate the relationships between body composition and the adherence to the Mediterranean diet (MD) with the severity of HS in a sample of naive-treatment patients with HS. Read More

Br J Dermatol 2018 Dec 30. Epub 2018 Dec 30.

Department of Dermatology, The Pennsylvania State University College of Medicine, Hershey, PA.

As defined by the European Dermatology Forum, Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease of the hair follicle in the axillae, inguinal and anogenital regions (Fig 1a, top). For severe cases, surgical management of lesions by "deroofing" is helpful. As first described by William Danby, sinus tracts contain an "invasive proliferative gelatinous mass (IPGM)" attached to the sinus tract epithelium[1]. Read More

Br J Dermatol 2018 Dec 30. Epub 2018 Dec 30.

PEDEGO Research Unit, University of Oulu, Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

Clin Exp Dermatol 2018 Dec 28. Epub 2018 Dec 28.

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

The clinical characteristics associated with hidradenitis suppurativa (HS) severity are poorly understood. In this study, 124 patients with HS from 6 Italian dermatology centres participated in this study. Disease severity was assessed using the Hidradenitis Suppurativa Physician's Global Assessment score (HS-PGA) and Hurley score. Read More

JAAPA 2019 Jan;32(1):47-48

Sunny Baker practices emergency medicine at Texas Tech University Medical Center in El Paso, Tex. The author has disclosed no potential conflicts of interest, financial or otherwise.

Br J Dermatol 2018 Dec 26. Epub 2018 Dec 26.

Department of Dermatology, Centre Hospitalier Universitaire de Bordeaux, F-33000, Bordeaux, France.

In Vivo 2019 Jan-Feb;33(1):141-143

Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland

Background/aim: Hidradenitis suppurativa (HS) is a chronic disease. Recently, we suggested, chitinase-3-like protein 1 (YKL-40) as a new biomarker for HS since its serum levels were found to be elevated in patients. The objective of this study was to examine YKL-40 tissue expression in HS. Read More

J Drugs Dermatol 2018 Dec;17(12):1330-1332

Dermatology is entering an exciting era with new, targeted immune-modulating medications for treating a variety of dermatologic conditions including psoriasis, atopic dermatitis (AD), and hidradenitis suppurativa. Previously, mainstay treatments consisted of topical corticosteroids or broad systemic immunosuppressants. Recently, our understanding of cytokine signaling cascades has grown, presenting new opportunities to target skewed immune responses. Read More

Br J Dermatol 2018 Dec 26. Epub 2018 Dec 26.

Department of Plastic, Reconstructive and Hand Surgery, Amsterdam University Medical Center, University of Amsterdam.

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory and recurrent skin disease. Different staging instruments have been suggested, but none has achieved universal acceptance. Despite the fact that the Hurley staging is one of the most widely applied HS disease severity staging instruments, it has not been validated. Read More

Diagn Interv Radiol 2019 Jan;25(1):21-27

Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey.

Anal and perianal region is a commonly affected area in the course of several inflammatory, infectious, and neoplastic diseases. Several imaging modalities may be used in imaging evaluation of this area and magnetic resonance imaging (MRI) emerges as the imaging modality of choice due to its superb soft tissue resolution. MRI is not only useful for initial detection of anal/perianal pathologies but also in the follow-up of these disorders. Read More

J Dermatolog Treat 2018 Dec 22:1-16. Epub 2018 Dec 22.

a Department of Dermatology , Tufts Medical Center , Boston MA.

Background: Hidradenitis suppurativa (HS) is a chronic immune mediated skin disorder characterized by inflamed, painful abscesses most commonly located in the intertriginous regions that may lead to significant scarring and social stigma. It is unclear how much patients with HS understand about their disease.

Objective: We sought to evaluate baseline knowledge of patients who have HS, as well as to evaluate if an educational intervention of a teaching session about the disease will help increase patient's knowledge of their ailment and treatment options. Read More