J Eur Acad Dermatol Venereol 2017 Aug 10. Epub 2017 Aug 10.

Aragonese Institute of Health Sciences. Miguel Servet University Hospital University of Zaragoza, Spain.

Background: The association between hidradenitis suppurativa (HS) and some diseases is becoming relevant in recent years. Providing appropriate management of HS from an early stage requires to include prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat HS potentially related to the onset of a comorbidity. Read More

J Eur Acad Dermatol Venereol 2017 Aug 10. Epub 2017 Aug 10.

Dept. of Dermatology, University hospital Zealand, Roskilde, Denmark.

Objectives: In recent years, Hidradenitis suppurativa has received increased attention, but still lack well-defined, robust patient reported outcome measures. Such measures are likely to be influenced by contextual factors. We therefore aim to describe the association of biological and other factors with HS patient's self-evaluated health as reflected by the EQ5D VAS score. Read More

F1000Res 2017 28;6:1272. Epub 2017 Jul 28.

Henry Ford Hospital Department of Dermatology, Detroit, MI, USA.

Hidradenitis suppurativa (HS) is a devastating disease involving abscesses, sinus tracts, and inflammation classically affecting the axilla, groin, and/or anogenital region. Although the disease pathogenesis is not fully understood, recent advances suggest that HS pathology runs much deeper than the cutaneous manifestations. It is now believed that HS is a systemic inflammatory disease that gives rise to the characteristic cutaneous manifestations. Read More

Australas J Dermatol 2017 Aug 9. Epub 2017 Aug 9.

Dermatology Research Group, Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia.

We report the first case series of hidradenitis suppurativa in patients of Indigenous Australian heritage. The incidence and ethnicity of populations affected by this condition are not known. The high comorbid disease burden and socioeconomic disadvantage that is well recognised in the Indigenous Australian population poses significant challenges to therapeutic outcomes. Read More

Aust Fam Physician 2017 ;46(8):584-588

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease presenting in intertriginous areas. HS is associated with a number of disease-modifying comorbidities, including metabolic syndrome and androgen dysfunction, and smoking.

Objective: This review provides a synopsis of the aetiology and diagnosis of HS, and an overview of management for this often devastating disease. Read More

Open Access Maced J Med Sci 2017 Jul 24;5(4):561-563. Epub 2017 Jul 24.

Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria.

We present a 55-year-old male patient - a smoker, admitted to a Medical Institute of MVR (Ministry of the interior, Sofia, Bulgaria), on occasion of pain and swellings, located in the area of both axillae, accompanied by purulent discharge, with bloody admixtures. Bilateral localised cystic rose above the skin surface, hyperpigmented nodules interconnected with multiple fistulas, was observed within the dermatological examination, resulting in a limitation of the possibility of movement of the hands in all directions. A subjective complaint of pain was obtained on palpation. Read More

Obstet Gynecol Clin North Am 2017 Sep;44(3):453-473

Total Dermatology Care Center P.A., 915 West Monroe Street, Suite 101, Jacksonville, FL 32204, USA. Electronic address:

This article discusses the clinical evaluation and approach to patients with 3 complex ulcerative vulvar conditions: hidradenitis suppurativa, metastatic Crohn disease of the vulva, and aphthous ulcers. These conditions are particularly challenging to medical providers because, although each is known to present with nonspecific examination findings that vary in morphology, the predominance of the diagnosis is based on clinical examination and exclusion of a wide variety of other conditions. Care of patients with these conditions is further complicated by the lack of therapeutic data and the significant impact these conditions have on quality of life. Read More

Mediators Inflamm 2017 10;2017:2450401. Epub 2017 Jul 10.

Unidad de Gestión Clínica de Dermatología, Hospital Universitario Puerta del Mar, Cádiz, Spain.

Objectives: To assess inflammatory serum markers including serum proinflammatory cytokines, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) according to the clinical inflammatory activity of patients with hidradenitis suppurativa (HS).

Patients And Methods: Seventy-four patients with HS were studied based on the Hidradenitis Suppurativa-Physician Global Assessment (HS-PGA) score and Hurley staging system. Proinflammatory cytokines were measured using a multiplex cytokine assay. Read More

J Obstet Gynaecol 2017 Aug 1:1-12. Epub 2017 Aug 1.

a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.

Chronic, inflammatory and ulcerating mucocutaneous diseases that can affect the vulvar area are reviewed: lichen sclerosus, lichen planus, plasma cell vulvitis, complex aphthosis, Behcet's disease, pyoderma gangrenosum, metastatic Crohn's disease, dyskeratotic skin diseases (Hailey-Hailey disease and Darier's disease), autoimmune bullous diseases (mucous membrane pemphigoid and pemphigus vulgaris) and hidradenitis suppurativa. Also, vulvodynia and vestibulodynia, zinc and vitamin B deficiency are described. Read More

Int J Dermatol 2017 Aug 1. Epub 2017 Aug 1.

Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.

Am J Clin Dermatol 2017 Jul 28. Epub 2017 Jul 28.

Department of Dermatology, Venereology, and Allergology, Wroclaw Medical University, Wrocław, Poland.

Presse Med 2017 Jul 24. Epub 2017 Jul 24.

Hôpital Saint-Antoine, service de gastroentérologie, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France.

Dermatology 2017 Jul 28. Epub 2017 Jul 28.

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.

Background: The pathogenesis of hidradenitis suppurativa (HS), with its complex inflammatory network, is still elusive. Imbalances in DNA methylation can lead to genome destabilization and have been assumed to play a role in inflammatory diseases. Global DNA methylation and hydroxymethylation have not been studied in HS yet. Read More

J Dermatolog Treat 2017 Aug 9:1-6. Epub 2017 Aug 9.

b Department of Dermatologic Surgery and Laser Unit, St. Thomas' Hospital , St. John's Institute of Dermatology , London , UK.

Background: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavorable conditions and antibiotics.

Methods: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. Read More

Ir Med J 2017 May 10;110(5):574. Epub 2017 May 10.

Royal Victoria Hospital, Belfast, Northern Ireland, BT12 6BA.

J Invest Dermatol 2017 Jul 20. Epub 2017 Jul 20.

PEDEGO Research Unit, University of Oulu; Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland. Electronic address:

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of hair follicles which is associated with various comorbidities. In order further to clarify the associations between HS and psychiatric disorders, we conducted a nationwide retrospective study that included 4381 patients with HS and 39554 psoriasis and 43248 melanocytic nevi patients as controls. Patient data were obtained from the statutory Finnish Care Register for Health Care. Read More

Clin Rev Allergy Immunol 2017 Jul 22. Epub 2017 Jul 22.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Unità Operativa di Dermatologia, Università degli Studi di Milano, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.

Rheumatoid arthritis and spondyloarthritis are inflammatory joint disorders with an autoimmune pathogenesis and systemic involvement. The skin is one of the most frequently affected extraarticular sites with a number of manifestations or distinct diseases, including common conditions, such as rheumatoid nodules and psoriasis, and rare diseases like neutrophilic dermatoses. The latter are clinically characterised by polymorphic lesions, including pustules, bullae, abscesses, papules, nodules, plaques and ulcers, and histologically by neutrophil-rich inflammatory infiltrates. Read More

Br J Dermatol 2017 Jul 22. Epub 2017 Jul 22.

Zealand University Hospital, Department of Dermatology, Roskilde, Denmark.

Patients suffering from Hidradenitis Suppurativa often complain of fatigue or tiredness, a common symptom in other chronic systemic inflammatory conditions.(1) Fatigue has been reported as a prodromal symptom in 32% of HS patients(1) , indicating that it is an important symptom in HS. This article is protected by copyright. Read More

Indian J Dermatol Venereol Leprol 2017 Sep-Oct;83(5):615-617

Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.

Pediatr Dermatol 2017 Jul 20. Epub 2017 Jul 20.

Department of Dermatology, Centro Hospitalar do Porto, Porto, Portugal.

Background: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. Read More

Cas Lek Cesk 2017 ;156(3):127-132

Hidradenitis suppurativa is a chronic skin disorder characterized by recurrent inflammatory nodules, fistulas, abscesses, and scarring mainly in the intertriginous areas with terminal hair and apocrine glands. Hidradenitis suppurativa manifests usually after puberty, in the third life decade and persists for many years. The prevalence of the disease is estimated to be 0,5 % in the Czech Republic. Read More

Br J Dermatol 2017 Jul 18. Epub 2017 Jul 18.

Universidade do Porto Ringgold Standard Institution - EpiUnit, Institute of Public Health, Porto, Portugal.

Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin (R+C) has been suggested as a possible treatment regimen (level of evidence III, strength of recommendation C). Read More

Br J Dermatol 2017 Jul 18. Epub 2017 Jul 18.

Johns Hopkins Medical Institutions, Department of Dermatology.

Hidradenitis suppurativa (HS) is a chronic and debilitating inflammatory skin disease that disproportionately affects women of childbearing age. Yet, little has been written about the impact of pregnancy on the natural history of HS. It has been postulated that apocrine-gland activity diminishes in pregnancy, accounting for symptom remission. Read More

J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):131-140

Anatomic Pathologic, Department of Molecular Medicine, University of Pavia, Pavia, Italy.

Hidradenitis Suppurativa (HS) is recently attracting much attention and awareness, often because it is misdiagnosed for years, restricting the therapeutic options. Moreover, this pathology arises in areas such as the inguinal region, that may cause embarrassment in young patients. Wrong diagnosis and delay in appropriate treatments lead to an exacerbation of the symptoms and a progression of the disease, which at the last stage can only be managed through extensive surgical excisions, ablation and vaporization of nodules with CO2 laser systems or aggressive chemotherapies such as anti-TNF-alpha like adalimumab (Humira®-AbbVie Inc. Read More

J Eur Acad Dermatol Venereol 2017 Jul 11. Epub 2017 Jul 11.

Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of Copenhagen, Denmark.

Background: Hidradenitis suppurativa (HS) is an inflammatory skin disease causing painful inflammation and suppuration. It may occur in rare syndromes: follicular occlusion, Bazex-Dupré-Christol, Down's, KID, PAPASH, PASS, PASH, and SAPHO syndromes, as well as Dowling-Degos disease. An overview of syndromic HS may inform the search for etiological factors in HS. Read More

Dermatology 2017 Jul 7. Epub 2017 Jul 7.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Hidradenitis suppurativa (HS) is a painful, inflammatory, debilitating skin disease with a chronic intermittent course. The central pathogenetic event seems to be the occlusion of the hair follicle. HS has a 1-year prevalence of about 1%. Read More

Sci Transl Med 2017 Jul;9(397)

Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, FL 33125, USA. Email:

Immunological data implicates IL-17 pathway in the pathogenesis of hidradenitis suppurativa. Read More

Dermatology 2017 Jul 4. Epub 2017 Jul 4.

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Background: Hidradenitis suppurativa is a skin disease of recurrent episodes of inflammatory nodules, abscesses, and scarring of the intertriginous regions, e.g. the axillae and groin. Read More

Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.

Department of Dermatology, Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Alicante, Spain.

Hidradenitis suppurativa (HS) is chronic recurrent inflammatory disease affecting intertriginous areas, especially the axilla and the groin(1) . It is characterized by painful, deep-seated, inflamed lesions, including nodules, abscesses, and sinus tracts(2) . A recent meta-analysis found an association between HS and traditional cardiovascular (CV) risk factors and metabolic syndrome(3) . Read More

Br J Dermatol 2017 Jul 1. Epub 2017 Jul 1.

Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.

Background: Hidradenitis Suppurativa (HS) is a chronic, inflammatory skin disease, recently associated with metabolic syndrome, subclinical atherosclerosis and increased risk of cardiovascular disease.

Objectives: The aim of the study was to investigate the hitherto unknown electrocardiographic changes associated with HS, which recently have been associated with significant cardiovascular burden.

Methods: Data were derived from the cross-sectional population study, The Danish General Population Study (GESUS). Read More

Br J Dermatol 2017 Jun 29. Epub 2017 Jun 29.

Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, NY.

Background: Hidradenitis Suppurativa (HS) has been linked to Down syndrome (DS).

Objective: To determine whether Down syndrome patients have a higher prevalence of HS, and whether diagnosis of HS occurs at an earlier age.

Methods: Cross-sectional analysis in a population sample of 11,936 DS patients and 16,813,290 non-DS patients. Read More

Dermatol Surg 2017 Jun 28. Epub 2017 Jun 28.

Department of Dermatology, Johns Hopkins University, School of Medicine, Baltimore, Maryland Johns Hopkins University, School of Medicine, Baltimore, Maryland.

Inflamm Res 2017 Jun 27. Epub 2017 Jun 27.

Faculty of Medicine, University of Toronto, Toronto, Canada.

Introduction: Hidradenitis suppurativa (HS) is a painful chronic inflammatory disease with a prevalence between 1 and 4% of general population. The pathogenesis of HS long eluded scientists, but growing evidence suggests that it is a consequence of inflammatory dysregulation.

Findings: Recent studies suggest that dysregulated immune response to skin flora and overexpression of inflammatory cytokines leads to chronic skin inflammation seen in HS. Read More

Dermatology 2017 Jun 28. Epub 2017 Jun 28.

Department of Dermatology, Deventer Hospital, Deventer, The Netherlands.

Br J Dermatol 2017 Jun 27. Epub 2017 Jun 27.

Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of Copenhagen, Denmark.

An inappropriate immunologic response to an unknown antigen has been suggested to play a role in the pathogenesis of Hidradenitis suppurativa (HS). Studies have identified elevated levels of several proinflammatory cytokines, including IL-17A and TNF-α, nominating these as possible therapeutic targets.(1) Secukinumab is an Il-17A monoclonal antibody, which binds to Il-17A and inhibits the cytokine interaction with the Il-17 receptors, inhibiting the inflammatory cascade. Read More

J Invest Dermatol 2017 Jun 23. Epub 2017 Jun 23.

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland; School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. Electronic address:

Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating disease of hair follicles with 1-4% prevalence and high morbidity. There is a dearth of information on the pathogenesis and immune dysregulation underlying HS therefore we carried out a detailed analysis of skin infiltrating T cells. Cells isolated from skin biopsies and blood from HS patients and healthy controls were analysed by 16-parameter flow cytometry to provide detailed profiles of CD4 T cell subsets. Read More

J Ultrasound Med 2017 Jun 26. Epub 2017 Jun 26.

Departments of Dermatology, Hospital Clinico, Faculty of Medicine, University of Chile, Santiago, Chile.

Objectives: To compare the sonographic characteristics of pilonidal cysts and hidradenitis suppurativa.

Methods: A retrospective study of sonographic examinations was performed on 2 groups: 1 with pilonidal cysts and the other with hidradenitis suppurativa. The sonographic characteristics of the pilonidal cyst and hidradenitis suppurativa groups were analyzed, compared, and correlated, including an analysis of the histologic findings. Read More

Dermatology 2017 Jun 23. Epub 2017 Jun 23.

School of Medicine, Queen's University, Kingston, ON, Canada.

Background: Hidradenitis suppurativa (HS) is a disease characterized by the development of painful, deep-seeded nodules and abscesses. Treatment guidelines include a combination of lifestyle, surgical, and medical interventions. Isotretinoin has not been included in the treatment guidelines due to the limited number of studies and conflicting reports of efficacy. Read More

J Cutan Med Surg 2017 Jun 1:1203475417716117. Epub 2017 Jun 1.

9 Centre de Recherche Dermatologique du Québec Metropolitain, Quebec, QC, Canada.

Background: Hidradenitis suppurativa (HS) is a painful, debilitating, and poorly understood condition, which is suboptimally diagnosed, managed, and treated. Evidence supporting various treatment modalities is sparse.

Objectives: To incorporate scientific evidence and expert opinions to develop useful guidance for the evaluation and management of patients with HS. Read More

Br J Dermatol 2017 Jun 21. Epub 2017 Jun 21.

Interdisciplinary Group of Molecular Immunopathology, Dermatology/Medical Immunology, Charité University Medicine, Berlin, Germany.

Background: A validated tool for the dynamic severity assessment of hidradenitis suppurativa (HS) is lacking. The aim of this study was to develop and validate such a novel scoring system.

Methods: A Delphi voting procedure was conducted among the members of the European Hidradenitis Suppurativa Foundation (EHSF) to achieve consensus towards an initial HS Severity Score System (HS4). Read More

Pediatr Dermatol 2017 Jul 21;34(4):461-464. Epub 2017 Jun 21.

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Background/objectives: Many dermatologic and systemic diseases have been reported in association with hidradenitis suppurativa, but its association with Down syndrome is rarely mentioned in the literature. The objective of the current study was to assess the frequency of hidradenitis suppurativa in patients with Down syndrome who visited our clinic over 4 years.

Methods: We recorded the presenting complaints and dermatologic problems of patients with Down syndrome who visited our clinic from January 2011 to December 2014. Read More

Arch Dermatol Res 2017 Jun 20. Epub 2017 Jun 20.

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Gudrunstr. 56, 44791, Bochum, Germany.

Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. in Wiley Interdiscip Rev RNA 6:271-289, 2015). The RNA-induced silencing complex (RISC) is the central element of the miRNA pathway and regulates miRNA formation and function. Read More

Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.

Department of Dermatology, University of Cincinnati, Cincinnati, Ohio.

Hidradenitis suppurativa (HS) is a chronic, inflammatory, debilitating disease of unknown etiology. HS can occur in people of all ethnicities and ages, and affects approximately 3-4% of the United States. To date, few studies have specifically examined the race prevalence of HS; further epidemiological research is needed to identify specific trends among HS and its racial predilections. Read More

Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.

Department of Dermatology and Venereology, University Hospital of Brest.

PASH syndrome is a clinical entity associating pyoderma gangrenosum (PG), severe acne and hidradenitis suppurativa (HS)(1) . Absence of pyogenic sterile arthritis (PA) distinguishes PASH syndrome from PAPASH and PAPA syndromes which associate PA in combination with PG, severe acne with or without HS, respectively(2,3) . Mutations in PSTPIP1 (proline-serine-threonine-phosphatase interacting protein 1) gene were identified in patients with PAPA and PAPASH syndromes, although genetic heterogeneity was observed in PAPA syndrome(2,3) . Read More

Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.

Department of Dermatology, Edouard Herriot Hospital, Claude Bernard Lyon I University, Lyon, France.

Rifampicin/Clindamycin (RC) combination is recommended as first line therapy in moderate to severe Hidradenitis Suppurativa (HS) by European S1 guidelines (1-3), notably because a large variety of microorganisms have been isolated from HS lesions: most represented bacteria appear to be Staphylococcus aureus, Coagulase negative staphylococci (CoNS) and anaerobic bacteria from normal skin flora. It has been hypothesized that these bacteria could play a central role in the initiation and maybe in the maintenance of HS lesions, possibly by being a source of antigens in a dysregulated immune response. This article is protected by copyright. Read More

J Am Acad Dermatol 2017 Jul;77(1):176-177

Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York.

World J Surg 2017 Jun 13. Epub 2017 Jun 13.

University of Michigan, TC 2124 University Hospital SPC 5343, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.

Background: Hidradenitis suppurativa is a painful and disfiguring chronic inflammatory condition affecting both men and women. Medical treatments, such as antibiotics and immunosuppressive agents, are often ineffective. Over time, patients can suffer from recurrent abscesses, chronic purulent drainage, scarring, and contractures that can only be corrected by surgical excision. Read More

Skin Appendage Disord 2017 Mar 1;3(1):39-56. Epub 2017 Feb 1.

Dermatology Unit, Department of Clinical and Molecular Sciences, United Hospital of Ancona, Polytechnic Marche University, Ancona, Italy.

Background: Botulinum toxin is a neurotoxin produced by the bacterium Clostridium botulinum which causes a flaccid muscle paralysis. It is currently used for aesthetic treatments and in the focal hyperhidrosis. Recently, botulinum toxin has also been used experimentally in many other dermatological conditions with good results. Read More

Skin Appendage Disord 2017 Mar 12;3(1):20-27. Epub 2017 Jan 12.

Department of Dermatology and Allergology, AbbVie Oy, Espoo, Finland.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that impacts the quality of life.

Methods: We evaluated its burden in a cohort of 26 Finnish patients in a single-center cross-sectional study. Demographic data, disease history, clinical data, treatment patterns, and workability were collected. Read More

J Dermatolog Treat 2017 Jun 29:1-3. Epub 2017 Jun 29.

a Department of Dermatology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.

Introduction: Hidradenitis suppurativa (HS) presents the problem of a chronic, relapsing, painful, draining wound. There is a myriad of HS wound care management strategies implemented by clinicians and patients centered around which dressings to use. Many factors affect which HS wound care dressing is the most appropriate to use such as the type of HS wound, cost, ease of application, patient comfort, absorbency and odor management among many others. Read More