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    Hidradenitis Suppurativa: Inside and Out.
    Indian J Dermatol 2018 Mar-Apr;63(2):91-98
    Department of Dermatology, Dr. D. Y. Patil Hospital, Navi Mumbai, Maharashtra, India.
    Hidradenitis suppurativa is a chronic, disabling, suppurative disease characterized by deep tender subcutaneous nodules; complicated by fibrosis and extensive sinuses affecting primarily the apocrine gland bearing areas. It affects all races in early 20s with greater prevalence seen in women (3 to 5:1). The estimated disease prevalence is 1 - 4 %. Read More
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    Hidradenitis Suppurativa Associated with Down Syndrome Is Characterized by Early Age at Diagnosis.
    Dermatology 2018 Apr 24:1-5. Epub 2018 Apr 24.
    Institute of Dermatology, Catholic University, Rome, Italy.
    Background/aims: The association between hidradenitis suppurativa (HS) and multiple comorbidities has been widely investigated but data about the coexistence of Down syndrome (DS) are scarce. We sought to evaluate the prevalence of DS among a population of HS patients and assess their clinical features.

    Methods: We collected demographic and clinical data of patients affected with HS referred to three Italian outpatient dermatology clinics. Read More
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    Hyperbaric oxygen therapy (HBOT) can improve the effectiveness of adalimumab in Hidradenitis Suppurativa: report of a case.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy.
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    Hidradenitis suppurativa/acne inversa: a prospective bacteriological study of 46 patients and review of the literature.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
    Background: Hidradenitis suppurativa is a chronic inflammatory disease of the hair follicle that usually involves specific anatomic areas which are partially occluded, have a higher density of eccrine and apocrine sweat glands and a higher pH. These characteristics could promote the superinfection of certain group of bacteria. We aimed to describe the bacteria that can be isolated from hidradenitis lesions and to establish a correlation between bacteriological results and clinical data. Read More
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    Penile and scrotal lymphedema associated with hidradenitis suppurativa: Case report and review of surgical options.
    Cir Cir 2018 ;86(1):84-88
    Servicio de Cirugía Plástica, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, España.
    Lymphedema is the result of an alteration of the lymphatic drainage, and its most common worldwide cause is filariasis. In our practice usually is associated to neoplasic, inflammatory and granulomatous processes, radiotherapy, hydroelectrolytic disbalances, and idiopathic. It can affect any part of the body, including the penis and scrotum. Read More
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    A note on improvement in Dermatology Life Quality Index (DLQI) among patients with hidradenitis suppurativa treated with adalimumab.
    J Dermatolog Treat 2018 Apr 19:1-7. Epub 2018 Apr 19.
    a Department of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital , Copenhagen , Denmark.
    Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with profound negative impact on quality of life. Adalimumab (anti-TNF) is indicated for moderate-to-severe HS unresponsive to conventional therapy. Herein, studies of the change in Dermatology Life Quality Index (DLQI) among patients with HS treated with adalimumab are reviewed. Read More
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    Prevalence Estimates For Hidradenitis Suppurativa Among Children and Adolescents in the United States: a gender and age adjusted population analysis.
    J Invest Dermatol 2018 Apr 13. Epub 2018 Apr 13.
    Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York, USA.
    The prevalence of Hidradenitis Suppurativa (HS) in the pediatric population is unknown. We sought to establish standardized overall as well as gender-, age-, and race-specific prevalence estimates of HS among children and adolescents in the United States. We performed a cross-sectional analysis in a heterogeneous sample of 55 million patients across all census regions. Read More
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    Poland Syndrome with Ipsilateral Hypoplasia of Gluteal Muscles and Contralateral Hidradenitis Suppurativa.
    Pol J Radiol 2017 20;82:616-620. Epub 2017 Oct 20.
    Department of Radiology, Saint Vincent's Medical Center, Bridgeport, CT, U.S.A.
    Background: Poland syndrome (PS) is a rare congenital anomaly associated with absent or hypoplastic pectoralis major muscle and a wide spectrum of ipsilateral thoracic and upper extremity deformities. Hidradenitis suppurativa (HS) is a recurrent inflammatory follicular disease that commonly affects the apocrine-bearing skin and involves follicular occlusion and hyperkeratosis.

    Case Report: We report a case of a 46-year-old male with a history of chronic recurrent hidradenitis suppurativa who was incidentally found to have a simple type of Poland syndrome with incidental hypoplasia of ipsilateral gluteal muscles. Read More
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    A Core Domain Set For Hidradenitis Suppurativa Trial Outcomes: An International Delphi Process.
    Br J Dermatol 2018 Apr 14. Epub 2018 Apr 14.
    Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of CopenhagenDenmark.
    Background: There is no consensus on core outcome domains for hidradenitis suppurativa (HS). Heterogeneous outcome measure instruments in clinical trials likely leads to outcome reporting bias and limits the ability to synthesise evidence.

    Objectives: To achieve global multi-stakeholder consensus on a Core Outcome Set (COS) of domains regarding what to measure in clinical trials for HS. Read More
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    S1 Guidelines - Dermatoses associated with dermal lymphostasis.
    J Dtsch Dermatol Ges 2018 Apr;16(4):512-523
    Former Department of Dermatology, Allergology, Phlebology, and Lymphology, Sanaderm Hospital, Bad Mergentheim, Germany.
    The objective of the present S1 guidelines is to present current knowledge about dermatologically relevant diseases associated with localized dermal lymphostasis, thus facilitating their early detection, diagnostic workup, and targeted treatment. Whenever possible, treatment should be based on stage-appropriate and clearly defined algorithms. The numerous issues regarding differential diagnosis and treatment clinicians are confronted with in everyday clinical practice seem to warrant the publication of up-to-date guidelines. Read More
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    Efficacy and tolerability of a lotion containing triethyl citrate, ethyl linoleate, and GT peptide-10 in the adjuvant treatment of hidradenitis suppurativa: Real-life data.
    Dermatol Ther 2018 Apr 11:e12599. Epub 2018 Apr 11.
    Dermatology Unit "Daniele Innocenzi," Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy.
    Hidradenitis suppurativa (HS) is a chronic disorder of terminal follicular epithelium in the apocrine gland-bearing areas. The long term therapy is based mainly on topical and/or systemic antibiotic use that could result in antibiotic resistance. The aim of our study was to present the real-life experience based on the efficacy and tolerability of a novel lotion containing triethyl-citrate, ethyl-linoleate, and g-peptide-10 in the treatment of mild to moderate HS that has already shown effectiveness in acne treatment. Read More
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    Hidradenitis Suppurativa-Like Condition Occurring After Microwave Sweat Gland Ablation.
    Dermatol Surg 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York Bay Area Cosmetic Dermatology, San Francisco, California Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York Bay Area Cosmetic Dermatology, San Francisco, California.
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    Association of Hidradenitis Suppurativa With T Helper 1/T Helper 17 Phenotypes: A Semantic Map Analysis.
    JAMA Dermatol 2018 Apr 4. Epub 2018 Apr 4.
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
    Importance: In spite of progress in understanding the mechanisms underlying hidradenitis suppurativa (HS) as an inflammatory skin disease, there is still a demand for an overview on immunopathogenesis of HS.

    Objective: To demonstrate the importance of the type 1/type 17 immune response in lesional HS skin by drawing a semantic connectivity map.

    Design, Setting, And Participants: Single-center case series of 24 patients with HS. Read More
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    Identification of HLA-DRB1 association to adalimumab immunogenicity.
    PLoS One 2018 3;13(4):e0195325. Epub 2018 Apr 3.
    Pharmacogenetics and Human Genetics, Genomics Research Center, AbbVie Inc., North Chicago, IL, United States of America.
    Anti-drug antibody formation occurs with most biological agents across disease states, but the mechanism by which they are formed is unknown. The formation of anti-drug antibodies to adalimumab (AAA) may decrease its therapeutic effects in some patients. HLA alleles have been reported to be associated with autoantibody formation against interferons and other TNF inhibitors, but not adalimumab. Read More
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    A retrospective study of the characteristics of patients with early-onset compared to adult-onset hidradenitis suppurativa.
    Int J Dermatol 2018 Mar 31. Epub 2018 Mar 31.
    1st Department of Dermatology, A.Syggros Hospital, University of Athens, Athens, Greece.
    Background: The mean age of onset of hidradenitis suppurativa (HS) is between 20 and 24 years. Very few data about patients with early-onset HS exist.

    Objective: To investigate the association of early-onset HS with the clinical characteristics: age, gender, body mass index (BMI), smoking, family history of HS, Hurley stage, and number of areas affected. Read More
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    Collagen deposition in chronic Hidradenitis Suppurativa: Potential role for CD163 macrophages.
    Br J Dermatol 2018 Mar 30. Epub 2018 Mar 30.
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Hidradenitis suppurativa (HS), an inflammatory disorder of hair follicles in intertriginous areas, manifests as debilitating acute subcutaneous nodules with subsequent chronic sinus tract formation and scarring. Given the limited effectiveness of medical therapies, targeting the immunomodulatory mechanisms that mediate disease progression is of great interest. This article is protected by copyright. Read More
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    Cutaneous squamous cell carcinoma complicating hidradenitis suppurativa: a review of the prevalence, pathogenesis, and treatment of this dreaded complication.
    Acta Dermatovenerol Alp Pannonica Adriat 2018 03;27(1):25-28
    Department of Dermatology, State University of New York, Downstate Medical Center, New York, NY, USA.
    Hidradenitis suppurativa (HS) is a chronic and debilitating skin disorder characterized by the formation of painful abscesses, draining sinus tracts, and scarring, predominantly in skin folds such as the axillae and the perineum. The exact prevalence of HS is unknown because the disease is often underreported, but it has been estimated to be as high as 4.1%. Read More
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    Hidradenitis suppurativa in children: The Henry Ford experience.
    Pediatr Dermatol 2018 Mar 25. Epub 2018 Mar 25.
    Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.
    Background: Although recent hidradenitis suppurativa studies have shown that early-onset disease is associated with a positive family history and more widespread disease, research in pediatric hidradenitis suppurativa is limited.

    Methods: Thirty-three children diagnosed with hidradenitis suppurativa during an 18-month period were included in this institutional review board-approved, retrospective chart review. Information on demographic characteristic, family history, and timing of onset (prepubescent vs postpubescent) was extracted. Read More
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    [Hidradenitis Suppurativa: Combined Treatment with Dermal Template, Skin Graft and Negative Pressure Wound Therapy, a Case Study].
    Acta Med Port 2018 Jan 31;31(1):59-62. Epub 2018 Jan 31.
    Serviço de Cirurgia Plástica, Reconstrutiva e Estética. Hospital São José. Centro Hospitalar Lisboa Central. Lisboa. Serviço de Cirurgia Plástica, Reconstrutiva e Estética. Hospital CUF Descobertas. Lisboa. Portugal.
    Hidrosadenitis supurativa is a chronic inflammatory disease with great physical and psychological impact. Although conservative treatments may be effective in mild forms of the disease, extensive surgical resection and reconstruction are necessary in more severe forms of the disease. The purpose of this paper is to describe our two-stage reconstructive procedure regarding this kind of disease. Read More
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    Th17/Treg imbalance in hidradentitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking, and autoimmune comorbidities.
    Br J Dermatol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Dermatology and Allergy, Ludwig-Maximilian-University of Munich, Munich, Germany.
    Background: Disintegration of the infundibula of terminal hair follicles (HF) in intertriginous skin areas exhibits the histological hallmark of hidradenitis suppurativa (HS)/acne inversa, featuring a dissecting terminal hair folliculitis. Elevated serum levels of interleukin 17 and local increase in the ratio of proinflammatory Th17 cells and antiinflammatory regulatory T cells (Tregs) have been reported. Perifollicular Tregs play a key role for HF stem cell homeostasis and infundibular integrity. Read More
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    Sex- and age-adjusted prevalence estimates of five chronic inflammatory skin diseases in France: results of the « OBJECTIFS PEAU » study.
    J Eur Acad Dermatol Venereol 2018 Mar 23. Epub 2018 Mar 23.
    Société Française de Dermatologie (SFD), Paris, France.
    Background: There are few population-based studies assessing the prevalence of skin diseases.

    Objectives: To estimate the prevalence of five chronic skin inflammatory diseases, i.e. Read More
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    A new nonsense mutation in the POGLUT1 gene in two sisters with Dowling-Degos disease.
    J Eur Acad Dermatol Venereol 2018 Mar 23. Epub 2018 Mar 23.
    INSERM UMR 1163, Imagine Institute, Université Paris Descartes - Sorbonne Paris Cité, France.
    Dowling-Degos disease (DD) (OMIM: 179850, 615327, 615674, 615696) is a rare autosomal-dominant genetic disorder belonging to the spectrum of reticulated pigmented dermatitis(1). Galli-Galli disease is considered as being a variant of DD, harboring all clinical, histological and genetics features of DD in association with acantholysis (2). In 2006, exome sequencing revealed loss-of-function mutations in KRT5 (cytokeratin 5) (p. Read More
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    Hidradenitis suppurativa associated with systemic lupus erythematosus: A case report.
    Medicine (Baltimore) 2018 Mar;97(12):e0186
    Rheumatology Unit, Ziv and Padeh Medical Centers.
    Rationale: Hidradenitis suppurativa (HS) is a chronic inflammatory condition characterized by recurrent swollen, deep, and painful abscesses. Several autoimmune conditions have been shown to be associated with HS including inflammatory bowel disease and spondyloarthropathies.

    Patient Concerns: 40-year-old female with systemic lupus erythematous (SLE) presented with recurrent abscesses and nodules on her extremities. Read More
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    Axillary Hidradenitis: Risk Factors for Recurrence after Surgical Excision in 214 Patients.
    Am Surg 2018 Mar;84(3):422-427
    Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the apocrine sweat glands. Although the mainstay of surgical treatment is excision, the disease has a high tendency to recur, for reasons that are not well understood. We sought to better characterize the natural history of this disease, focusing on patients who required operative intervention. Read More
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    A Canadian Population-Based Cohort to the Study Cost and Burden of Surgically Resected Hidradenitis Suppurativa.
    J Cutan Med Surg 2018 Mar 1:1203475418763536. Epub 2018 Mar 1.
    1 Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
    Background: Hidradenitis suppurativa (HS) is a chronic debilitating disease with long-lasting comorbidities that impose direct and indirect costs on the health care system. However, limited studies have estimated the burden of this disease in Canada, and no population-based studies have previously addressed this condition.

    Objectives: This work describes the characteristics of a population-based HS cohort to address the existing knowledge gap on the burden of HS for the Canadian health care system. Read More
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    Somatic and psychiatric comorbidities of hidradenitis suppurativa in children and adolescents.
    J Am Acad Dermatol 2018 Mar 5. Epub 2018 Mar 5.
    PEDEGO Research Unit, University of Oulu, Oulu, Finland; Department of Dermatology and Medical Research Center Oulu Oulu, Finland. Electronic address:
    Background: Hidradenitis suppurativa (HS) is associated with various somatic and psychiatric comorbidities. Data regarding comorbidities in young patients with HS are sparse.

    Objective: We analyzed both somatic and psychiatric comorbidities in young patients in a nationwide HS cohort. Read More
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    Acute Erythroderma in a Patient Receiving TNF-α-Blocking Therapy for Hidradenitis Suppurativa.
    Case Rep Dermatol 2018 Jan-Apr;10(1):7-12. Epub 2018 Jan 31.
    Dermatology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium.
    Tumor necrosis factor-α (TNF-α) normally binds to TNF-α receptors, leading to the inflammatory response of autoimmune diseases. Adalimumab is a TNF-inhibiting, anti-inflammatory, biological medication which binds to TNF-α, thus reducing this inflammatory response. The use of TNF-α-inhibiting medication, such as adalimumab, being the first FDA-approved treatment for hidradenitis suppurativa, has drastically changed the management of dermatological diseases. Read More
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    An update on the pathogenesis of hidradenitis suppurativa: implications for therapy.
    Expert Rev Clin Immunol 2018 Apr 12;14(4):275-283. Epub 2018 Mar 12.
    a Department of Dermatology , Wake Forest School of Medicine , Winston Salem , NC , USA.
    Introduction: Hidradenitis suppurativa is a chronic, inflammatory disease characterized by painful nodules, abscesses, and sinuses in the intertriginous areas, with significant associated comorbidities. The pathogenesis remains unclear, although advances have been made in understanding the disease process. Management of the disease is challenging, with a wide range of treatment options available with variable clinical response. Read More
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    The Role of Therapy in Impairing Quality of Life in Dermatological Patients: A Multinational Study.
    Acta Derm Venereol 2018 Mar 2. Epub 2018 Mar 2.
    Department of Dermatology, Stavanger University Hospital, Pb. 8100, NO-4068 Stavanger, Norway.
    Skin disease and its therapy affect health-related quality of life (HRQoL). The aim of this study was to measure the burden caused by dermatological therapy in 3,846 patients from 13 European countries. Adult outpatients completed questionnaires, including the Dermatology Life Quality Index (DLQI), which has a therapy impact question. Read More
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    Opioid, alcohol, and cannabis misuse among patients with hidradenitis suppurativa: A population-based analysis in the United States.
    J Am Acad Dermatol 2018 Mar 1. Epub 2018 Mar 1.
    Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.
    Background: Patients with hidradenitis suppurativa (HS) experience chronic pain and have significant physical, emotional, and psychological disease impact. These patients may be at risk for substance abuse.

    Objective: To evaluate substance use disorder (SUD) among patients with HS in the United States. Read More
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    Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color.
    Dermatology 2017 1;233(6):456-461. Epub 2018 Mar 1.
    Division of Dermatology, Department of Medicine, University of Arizona, Tucson, Arizona, USA.
    Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease. Although most studies on HS are conducted in largely Caucasian populations, evidence demonstrates a higher prevalence in patients with skin of color, including African and Hispanic populations. These racial subgroups are likely at risk for greater disease burden due to a higher prevalence of components of the metabolic syndrome, comorbid depression, and low socioeconomic status; however, there is a paucity of research in these populations. Read More
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    Insulin resistance in hidradenitis suppurativa: a case-control study.
    J Eur Acad Dermatol Venereol 2018 May 23;32(5):820-824. Epub 2018 Mar 23.
    Division of Dermatology, Hospital Universitario Marques de Valdecilla, IDIVAL, University of Cantabria, Santander, Cantabria, Spain.
    Background: The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine gland-bearing areas of the body.

    Objective: We aimed to determine the prevalence of IR in patients with HS. Read More
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