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J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Dermatology, Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain.

Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a great impact in quality of life. However, there is little research about the impact of HS on sex life. The aims of this study are to describe the frequency of sexual distress (SD) in patients with HS and to explore potentially associated epidemiological and clinical factors. Read More

Dermatology 2019 Apr 17:1-11. Epub 2019 Apr 17.

Department of Clinical Immunology and Immunotherapy, Medical University of Lublin, Lublin, Poland.

Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequent S. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis. Read More

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

Importance: The overall comorbidity burden among patients with hidradenitis suppurativa (HS) has not been systematically evaluated.

Objectives: To investigate the standardized overall comorbidity burden among patients with HS and to compare it with the comorbidity burden in patients with psoriasis and a control group.

Design, Setting, And Participants: A cross-sectional analysis was conducted of 5306 patients with HS, 14 037 patients with psoriasis, and 1 733 810 controls identified using electronic health records data from October 1, 2013, through October 1, 2018. Read More

JAAD Case Rep 2019 Apr 3;5(4):326-328. Epub 2019 Apr 3.

Dermatology Clinic, University of Catania, Catania, Italy.

J Eur Acad Dermatol Venereol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Erasmus MC, University Medical Center Rotterdam, the Netherlands.

Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease characterized by recurring abscesses, nodules and draining fistulas in the intertriginous regions of the body. Anogenital involvement is present in 18.8% of HS patients. Read More

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Department of dermatology, allergology and venereology, Helsinki University Central Hospital, Helsinki, Finland.

Migraine is the most common primary headache syndrome worldwide, affecting approximately 12% of the Caucasian population [1]. Migraine has been associated with various cardiovascular [2] and psychiatric co-morbidities [3], more recently inflammatory disorders such as psoriasis [4] and inflammatory bowel disease [5]. As hidradenitis suppurativa (HS) shares common comorbidity risks, we sought to investigate the possible link between migraine and HS. Read More

Br J Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, APHP Hôpital St-Louis, Paris.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of skin appendages, commonly associating with other conditions including spondyloarthritis, and is a major component of severe cutaneo-articular autoinflammatory syndromes (AIS), called PAPASH (Pyogenic Arthritis, pyoderma gangrenosum/PG, Acne, HS), PsAPASH (Psoriatic Arthritis, PG, Acne, HS) and PASS (Ankylosing Spondylitis, Acne, PG and HS). The clinical phenotypes of these AIS are ill-defined and unlike PASH or PAPA syndromes, still lack any biological or genetic marker. Moreover, their optimal therapeutic management remains unclear. Read More

Front Pharmacol 2019 26;10:282. Epub 2019 Mar 26.

UOC Dermatologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Targeted immune-modulating treatment with biological agents has revolutionized the management of immune-mediated inflammatory diseases, including rheumatologic conditions. The efficacy and tolerability of biological agents, from the initial tumour necrosis factor (TNF)-α inhibitors to the new anti-cytokine monoclonal antibodies, have dramatically changed the natural history of debilitating conditions such as rheumatoid arthritis and seronegative spondyloarthropathies. The widening use of biologics across several rheumatologic diseases has been associated with a new class of adverse events, the so-called paradoxical reactions. Read More

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

European Hidradenitis Suppurativa Foundation e.V, Dessau, Germany.

Core outcome domains represent a major need in hidradenitis suppurativa/acne inversa (HS) as reliable disease classification systems and treatment outcome parameters. Thorlacius et al. reported recently that none of the HS classifications systems could be recommended when used with HS experts as raters without a preceding bedside training session. Read More

Dermatol Ther 2019 Apr 9:e12910. Epub 2019 Apr 9.

IDI-IRCCS, via dei Monti di Creta 104, 00167, Rome, Italy.

Cir Cir 2019 ;86(1):77-80

Department of Plastic Surgery, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain.

Lymphedema is the result of an alteration of the lymphatic drainage, and its most common worldwide cause is filariasis. In our practice usually is associated to neoplasic, inflammatory and granulomatous processes, radiotherapy, hydroelectrolytic disbalances, and idiopathic. It can affect any part of the body, including the penis and scrotum. Read More

J Dermatolog Treat 2019 Apr 4:1-2. Epub 2019 Apr 4.

a Laboratory of Investigative Dermatology , Rockefeller University , New York , NY , USA.

The pathogenesis of hidradenitis suppurativa (HS) centers around Th17/Treg dysfunction illustrated by lesional elevation of IL-17A, IL-6, and other inflammatory mediators resulting in a chronic feed-forward inflammatory cascade. Similar inflammatory mechanisms have been identified in psoriasis and rheumatoid arthritis (RA) in which traditional immunosuppressants (including methotrexate) are routinely used with reasonable levels of disease control. Methotrexate's mechanism of action in these instances includes downregulation of the Th17 axis via alterations in dendritic cell and T-cell activity and maturation. Read More

Dermatol Ther 2019 Apr 4:e12885. Epub 2019 Apr 4.

Dermatology Department, Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Granada, Spain.

J Dermatolog Treat 2019 Apr 2:1-10. Epub 2019 Apr 2.

a Division of Dermatology, Department of Medicine , David Geffen School of Medicine at UCLA , Los Angeles , CA , USA.

Purpose: Apremilast is a phosphodiesterase-4 inhibitor FDA approved for psoriatic arthritis and moderate to severe plaque psoriasis. In recent years, multiple studies have suggested other potential uses for apremilast in dermatology. A summary of these various studies will be a valuable aid to dermatologists considering apremilast for an alternative indication. Read More

Br J Dermatol 2019 Apr;180(4):702-703

The Charles Centre, Department of Dermatology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.

Br J Dermatol 2019 Apr;180(4):712-713

Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 151, Beer Sheva 84101, Israel.

Br J Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Laboratory for Investigative Dermatology, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, U.S.A.

We thank Dr van Straalen and Dr van der Zee for their response to our article. We agree that exploring genotype-phenotype correlation in inherited hidradenitis suppurativa (HS) is an important step in improving our understanding of the disease and optimizing patient care. We also acknowledge that as an 'exploratory' analysis there are limitations in our methodology of establishing phenotypes that are inherent in compiling limited clinical information with lack of face-to-face clinical examination. Read More

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Medicine, Division of Dermatology, University of Toronto, Toronto, ON, Canada.

The 3 Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on October 12-14, 2018 at the Women's College Hospital in Toronto, Ontario, Canada. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF) founded in the USA, and the Canadian Hidradenitis Suppurativa Foundation (CHSF). This cross-disciplinary meeting with experts from around the world was an opportunity to discuss the most recent advances in the study of hidradenitis suppurativa pathogenesis, epidemiology, classification, scoring systems, radiologic diagnosis, treatment approaches, and psychologic assessment. Read More

G Ital Dermatol Venereol 2019 Mar 29. Epub 2019 Mar 29.

Unità Operativa di Dermatologia, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

Indian J Dermatol Venereol Leprol 2019 Mar 20. Epub 2019 Mar 20.

Department of Trauma and Orthopaedic Surgery, Montpellier University Hospital, Montpellier, France.

Hidradenitis suppurativa is a chronic inflammatory condition that affects skin regions bearing apocrine glands. Although hidradenitis suppurativa is difficult to treat and cure, the currently available treatments are directed toward managing the lesions and associated symptoms. This review presents an evidence-based outline of the available treatment options. Read More

Br J Dermatol 2019 Mar 28. Epub 2019 Mar 28.

RésoVerneuil.

Garg et al. recently pinpointed the fact that cannabis use was more common in HS patients (1.2%) compared to the general population (0. Read More

Br J Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Zealand University Hospital, Roskilde; Health Sciences Faculty, University of Copenhagen, Denmark.

Background: Pain is a prominent symptom of Hidradenitis suppurativa (HS) and has been defined as a domain in the Core Outcome Set for the disease. In addition, quality and intensity of pain is influenced by depression and anxiety both of which are associated with HS.

Objectives: To describe HS-related pain quantitatively as well as qualitatively. Read More

Br J Dermatol 2019 Mar 27. Epub 2019 Mar 27.

ResoVerneuil, Paris, France.

Background: Hidradenitis suppurativa (HS), also referred to as acne inversa, is a debilitating skin disease characterized by inflammatory nodules, chronic abscesses and tunnels (fistulae and sinuses). The association with pilonidal sinus disease is frequently reported but not well documented.

Objective: To determine the prevalence and characteristics of inflammatory skin lesions located in the intergluteal fold (IGF) of HS patients. Read More

Br J Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina.

Hidradenitis suppurativa (HS) is a chronic, inflammatory condition characterized by recurrent abscesses and scarring. The pain, malodorous discharge and cosmetic aspects of the lesions in HS can impair quality of life. The Dermatology Life Quality Index (DLQI) is a validated and reliable measure that assesses the impact of skin disease on quality of life (QoL). Read More

Br J Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Harvard Medical School and Beth Israel Deaconess Hospital, Boston, MA, United States.

Background: Weekly adalimumab (Humira ) is approved for treatment of hidradenitis suppurativa (HS) based on the 12-week, placebo-controlled periods of the two, phase-3 PIONEER trials.

Objectives: From PIONEER integrated trial results, we evaluated the optimal medium-term adalimumab maintenance dosing strategy in moderate-to-severe HS.

Methods: Each trial had two double-blind periods; 12-week Period A and 24-week Period B. Read More

J Eur Acad Dermatol Venereol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Zealand University Hospital, Roskilde, Health Sciences Faculty, University of Copenhagen, Denmark.

Background: Hidradenitis Suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. Recent Next Generation Sequencing (NGS) studies suggest genera such as Prevotella spp., Peptoniphilus spp. Read More

Br J Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Roskilde Zealand University Hospital, Roskilde, Denmark.

We greatly appreciate the concept of Critically Appraised Topics (CATs) in your excellent journal. The format is very useful in the clinical management of cases and may change routine concepts. In view of the recent CAT on the safety of extended use of rifampicin in the management of hidradenitis suppurativa (HS) we would like to suggest the addition of an important Knowledge-based ITeraTion of Evidence Notification (KITTEN). Read More

Rev Esp Salud Publica 2019 Mar 25;93. Epub 2019 Mar 25.

Medicina Preventiva y Salud Pública, Universidad Rey Juan Carlos, Madrid, Spain.

Objective: Immune-mediated inflammatory diseases (IMID) are chronic and highly disabling diseases that share inflammatory sequences and immunological dysregulations. Considered as a disease in itself, the prevalence of IMID is virtually unknown. The aim of this study was to assess the prevalence of 10 selected UDI, including rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, hidradenitis suppurativa, sarcoidosis and uveitis in Spain. Read More

Exp Dermatol 2019 Mar 23. Epub 2019 Mar 23.

EA 7509 IRMAIC, UFR medicine, University of Champagne-ArdenneReims, France.

Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle, associated with considerable tissue remodeling. Although abnormal cytokines expression was detected both in perilesional and in uninvolved skin, up to now there is no model allowing a better understanding of the implicit inflammatory mechanisms in HS. The aim of this study was to investigate the inflammatory response in HS skin by mean of an ex vivo model culture. Read More

J Cutan Med Surg 2019 Mar 22:1203475419839965. Epub 2019 Mar 22.

1 Center for Dermatology Research, Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Background:: Hidradenitis suppurativa (HS) is a debilitating dermatologic condition presenting with recurrent abscesses. While there are multiple scales to determine HS severity, none are designed for self-administration. A validated severity self-assessment tool may facilitate survey research and improve communication by allowing patients to objectively report their HS severity between clinic visits. Read More

Pediatr Dermatol 2019 03;36(2):249-250

J Dermatolog Treat 2019 Mar 20:1-3. Epub 2019 Mar 20.

a The Charles Centre, Department of Dermatology , St Vincent's University Hospital , Dublin , Ireland.

Background: Hidradenitis suppurativa (HS) is a chronic debilitating inflammatory disease, associated with metabolic syndrome, obesity and insulin resistance. Metformin, an oral hypoglycaemic agent, may play an important role in delaying or preventing the onset of diabetes and metabolic syndrome. Metformin has been reported as having efficacy in HS. Read More

Cutis 2018 Feb;102(2):93-94

Department of Dermatology, The University of Tennessee Health Science Center, Memphis, USA.

Plaque psoriasis is a chronic inflammatory disease driven by the proliferation of T cells and the production of several immunomodulators such as tumor necrosis factor (TNF) α. Tumor necrosis factor α plays a key role in multiple inflammatory conditions, including psoriatic arthritis, rheumatoid arthritis, and hidradenitis suppurativa. We present a patient with plaque psoriasis and sickle cell disease who began treatment with the TNF-α inhibitor adalimumab. Read More

Dermatol Surg 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Hospital de Manises, Valencia, Spain.

Background: Recent studies suggest that there are different fistular subtypes in hidradenitis suppurativa (HS) patients who are associated with variable therapeutic outcomes.

Objective: To describe clinical and ultrasound features that characterize the different fistular patterns in HS and to evaluate the response to medical therapies.

Methods: A retrospective study developed by a well-recognized center specialized in HS analyzing both clinical and ultrasound (US) aspects of fistular structures in HS patients was performed. Read More

Dermatol Surg 2019 Apr;45(4):527-528

Bennett Surgery Center, Inc, Santa Monica, California David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California Keck School of Medicine, University of Southern California, Los Angeles, California.

JAAD Case Rep 2019 Mar 1;5(3):261-263. Epub 2019 Mar 1.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Actas Dermosifiliogr 2019 Mar 15. Epub 2019 Mar 15.

Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background: Hidradenitis suppurativa is a chronic recurrent systemic inflammatory disease that mainly involves large skin folds. It develops when pilosebaceous units become blocked, leading to the formation of painful nodules, abscesses, fistulas, and scarring. The impact of this disease on quality of life is great. Read More

Plast Reconstr Surg Glob Open 2019 Feb 5;7(2):e2096. Epub 2019 Feb 5.

Department of Plastic Surgery, SOMER Clinic, Rionegro, Colombia.

Stage IV hidradenitis suppurativa in the axilla is a chronic disease in which the removal of the affected area and a reconstruction with disease free skin is the definitive treatment; however there is some controversy about the technique to be used in this reconstruction. Studies show superiority in wide resections, and coverage with flaps rather than grafts. The use of pedicle flaps of lateral thoracic artery perforators and thoracodorsal artery perforators has demonstrated superior performance to other techniques in postsurgical follow-up. Read More

Arch Dermatol Res 2019 May 15;311(4):331-335. Epub 2019 Mar 15.

Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.

Mast cells (MC) have been observed in hidradenitis suppurativa (HS) lesions. Their potential role in the pathogenesis of HS is unknown. The aim of this study was to assess the number and distribution MC in HS lesions, and its association with disease and itch severity. Read More

J Am Acad Dermatol 2019 Apr;80(4):1137-1139

Department of Dermatology, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address:

J Eur Acad Dermatol Venereol 2019 Mar 15. Epub 2019 Mar 15.

Klinikum Darmstadt GmbH, Heidelberger Landstrasse 379, 64297, Darmstadt.

We completely agree with Dr. Frew's comment that comparing results of clinical trials requires consistent outcome measures. HiSCR has been used as a primary endpoint outcome measure in multiple RCTs. Read More

J Eur Acad Dermatol Venereol 2019 Mar 15. Epub 2019 Mar 15.

Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY, USA.

Br J Dermatol 2019 Mar 15. Epub 2019 Mar 15.

Department of Dermatology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Recently a study conducted by Frew et al. was published in the British Journal of Dermatology. Frew et al. Read More

J Am Acad Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Centre de Recherche Dermatologique du Quebec Metropolitain, Quebec, 2880 Chemin des Quatre-Bourgeois, Quebec, QC G1V 4X7, Canada.

Hidradenitis suppurativa is a chronic inflammatory disorder affecting hair follicles with profoundly negative impact on patient quality of life. Evidence informing ideal evaluation and management of patients with hidradenitis suppurativa is still sparse in many areas, but has grown substantially in the last decade. Part I of this evidence-based guideline is presented to support health care practitioners as they select optimal management strategies including diagnostic testing, comorbidity screening, and both complementary and procedural treatment options. Read More

J Am Acad Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-FISABIO Foundation), Alicante, Spain.

J Am Acad Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Clinical Medicine and Surgery - Section of Dermatology - University of Naples Federico II Naples - Itlay.

J Am Acad Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Centre de Recherche Dermatologique du Quebec Metropolitain, Quebec, 2880 Chemin des Quatre-Bourgeois, Quebec, QC G1V 4X7, Canada.

Hidradenitis suppurativa is a severe and debilitating dermatologic disease. Clinical management is challenging and consists of both medical and surgical approaches, which must often be combined for best outcomes. Therapeutic approaches have evolved rapidly in the last decade and include the use of topical therapies, systemic antibiotics, hormonal therapies, and a wide range of immunomodulating medications. Read More

Front Immunol 2019 25;10:302. Epub 2019 Feb 25.

Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY, United States.

Actas Dermosifiliogr 2019 Mar 8. Epub 2019 Mar 8.

Servicio de Dermatología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, España.

In recent years, the growing interest in the role played by vitamin D in skin disease has given rise to the publication of many studies of the relationship between this vitamin and certain skin conditions. As dermatologists, we need to understand, among other aspects, how vitamin D is synthesized and the main sources in humans, as well as plasma levels and the factors that can modify them. Of particular interest are the latest discoveries about the role of vitamin D in skin diseases such as lupus erythematosus, ichthyosis, atopic dermatitis, hidradenitis suppurativa, acne, alopecia areata, androgenetic alopecia, melanoma, and nonmelanoma skin cancer. Read More

Ther Adv Chronic Dis 2019 1;10:2040622319830646. Epub 2019 Mar 1.

Laboratory of Investigative Dermatology, The Rockefeller University, New York, NY, USA.

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the skin, manifesting in chronic, recurrent painful pustules, nodules, boils and purulent draining abscesses. Our current understanding of the pathogenesis of the disease is incomplete. This review aims to identify available treatment options in HS and discuss the pharmacological mechanisms through which such agents function. Read More