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Br J Dermatol 2018 Dec 15. Epub 2018 Dec 15.

British Association of Dermatologists, Willan House, 4 Fitzroy Square, London, W1T 5HQ, U.K.

The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of hidradenitis suppurativa (HS). The document aims to:. offer an appraisal of all relevant literature up to July 2018, focusing on any key developments. Read More

Hum Mol Genet 2018 Dec 13. Epub 2018 Dec 13.

Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, MassGeneral Institute for Neurodegenerative Diseases, Harvard Medical School, Charlestown, MA, USA.

Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory skin disorder characterized clinically with acne-like lesions in apocrine gland-bearing skin, follicular occlusion and recurrent inflammation. Thirty-four unique mutations in patients with HS have been found in three genes encoding the γ-secretase complex: nicastrin (NCSTN), presenilin 1 (PSEN1), presenilin enhancer 2 (PSENEN) and in POGLUT1, an endoplasmic reticulum (ER) O-glucosyltransferase involved in Notch signaling. We have carried out a system review and have performed a functional analysis of the 34 unique reported HS-linked mutations in NCSTN, PSEN1, PSENEN and POGLUT1. Read More

Local Reg Anesth 2018 15;11:87-90. Epub 2018 Nov 15.

Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA,

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the terminal hair follicle of the apocrine gland-bearing skin, presenting with inflamed nodules, abscesses, and sinus tracts. Autoimmune, genetic, and infectious factors have been implicated in its pathogenesis. HS can be managed medically using topical and systemic antibiotics and with tumor necrosis factor antibody therapy in severe cases. Read More

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

CHRU of Tours, Department of Dermatology, 37044 Tours, France, Universities of Tours and Nantes, SPHERE-INSERM 1246, Tours, France.

J Invest Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Interdisciplinary group Molecular Immunopathology, Dermatology / Medical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany; Psoriasis Research and Treatment Center, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disease characterized by painful purulent skin lesions and progressive destruction of skin architecture. Despite the high burden for the patients, pathogenetic pathways underlying HS alterations remain obscure. Investigating the lesional HS cytokine pattern, IL-1β turned out as a highly prominent cytokine, being overexpressed even compared to psoriatic lesions. Read More

J Clin Aesthet Dermatol 2018 Oct 1;11(10):17-23. Epub 2018 Oct 1.

Drs. Vinkel and Thomsen are with the Department of Dermatology at Bispebjerg Hospital in Copenhagen, Denmark.

Hidradenitis suppurativa (HS), a relatively common and chronic inflammatory skin disorder. HS can have debilitating consequences if not diagnosed and treated appropriately. Clinically defined by recurrent, inflamed nodules in intertriginous regions (i. Read More

Br J Dermatol 2018 Dec;179(6):e226

Department of Dermatology, Chang Gung Memorial Hospital, No. 5 Fuxing St, Guishan District, Taoyuan, 33305, Taiwan.

Int J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Division of Dermatology, Department of Medicine, National University Health System, Singapore, Singapore.

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Dermatology Department, Department of Systems Medicine.

Background: Antibiotics are recognized as first-line treatments for Hidradenitis Suppurativa (HS), but there is limited data on their efficacy.

Objective: Evaluate the efficacy of oral clindamycin versus clindamycin plus rifampicin in HS patients.

Methods: Sixty mild to moderate-severe HS patients classified according IHS4 and Hurley scores, were subdivided into two groups of 30 patients each (Group A receiving clindamycin+rifampicin and Group B treated with clindamycin alone), and retrospectively studied. Read More

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel; Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: The coexistence of psoriasis and hidradenitis suppurativa (HS) has been described, but the association between these conditions is yet to be firmly established.

Objectives: To study the association between psoriasis and HS using a large-scale real-life computerized database.

Methods: A cross-sectional study was conducted comparing the prevalence of HS among patients with psoriasis and among age-, sex- and ethnicity-matched control subjects. Read More

Dermatol Ther 2018 Dec 5:e12792. Epub 2018 Dec 5.

Department of Surgery and Translational Medicine, Section of Dermatology, University of Florence, Florence, Italy.

Background And Objective: The Rifampicin (RF) - Clindamycin (CL) combination is recommended as first line therapy in moderate to severe Hidradenitis Suppurativa (HS) by European S1 guidelines. Although prolonged use of RF should be discouraged, there are currently few alternatives to this combination therapy. The aim of this study was to assess retrospectively the efficacy of oral CL monotherapy in patients diagnosed with HS. Read More

Int J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

We read with great interest the article by J. W. Frew regarding Notch Dysregulation as an Epiphenomenon in Inflammatory Skin Diseases. Read More

Eur J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Background: Hidradenitis suppurativa (HS) is a chronic, debilitating, heterogeneous disease requiring different treatment approaches. Recently, we refined the classic Hurley classification into a seven-stage classification in order to guide these treatment choices. This new classification subdivides Hurley stage I and II into three sub-stages namely mild (A), moderate (B), and severe (C) HS disease. Read More

Ann Chir Plast Esthet 2018 Nov 30. Epub 2018 Nov 30.

Département de chirurgie plastique, reconstructrice, brûlés, plaies et cicatrisation, CHU Lapeyronie, 371, avenue du Doyen Gaston-Giraud, 34295 Montpellier, France; Département de chirurgie plastique et craniofaciale pédiatrique, CHU Lapeyronie, 34295 Montpellier, France. Electronic address:

Objectives: The objective of this study was to compare the use of artificial dermal and perforator flap after radical surgery of severe axillary and perineal hidradenitis suppurativa disease.

Patients And Methods: The data on postoperative outcomes, scar assessment (POSAS) and quality of life (DLQI, SF-36) were collected during consultation or by phone call. Forty-seven patients were included in our study between January 2015 and September 2017, including 27 patients in the artificial dermal group and 20 patients in the perforator flap group. Read More

Br J Dermatol 2018 Nov 29. Epub 2018 Nov 29.

Ankara University, Department of Dermatology and Venereology, Ankara, Turkey.

Background: Hidradenitis suppurativa (HS) is a rare, debilitating neutrophilic dermatosis characterised by chronic inflammation of hair follicles. Many inflammatory conditions may accompany HS.

Aim: To investigate the association of variants of the MEFV gene with a complex HS phenotype. Read More

Exp Dermatol 2018 Nov 28. Epub 2018 Nov 28.

The Rockefeller University, New York, NY, USA.

The 2nd Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 03-05 November 2017 in Detroit, Michigan, USA. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF Inc.) founded in the USA, and the Canadian Hidradenitis Suppurativa Foundation (CHSF). Read More

J Am Acad Dermatol 2018 Jul 3. Epub 2018 Jul 3.

Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Effective anti-inflammatory treatments for hidradenitis suppurativa (HS) are limited.

Objective: To evaluate the efficacy and short-term safety of apremilast in patients with moderate HS.

Methods: A total of 20 patients with moderate HS were randomized in a 3:1 ratio to receive blinded treatment with apremilast, 30 mg twice daily, or placebo for 16 weeks. Read More

J Eur Acad Dermatol Venereol 2018 Nov 27. Epub 2018 Nov 27.

Klinikum Darmstadt GmbH, Heidelberger Landstrasse 379, 64297, Darmstadt.

Hidradenitis suppurativa (HS) is a chronic skin disease characterized by auto-inflammation resulting in abscesses, nodules, fistula and scaring in the affected areas. It is known as one of the most life restricting diseases in dermatology with highly negative effects regarding the DLQI. Despite the uprising therapeutic approaches available for HS, there is still a need for more effective medications to treat this auto-inflammational disease. Read More

Cureus 2018 Sep 17;10(9):e3319. Epub 2018 Sep 17.

Plastic and Reconstructive Surgery, University of Maryland School of Medicine, Baltimore, USA.

Background: Hidradenitis suppurativa (HS) is a physically debilitating disease that greatly impairs the quality of life of affected individuals. Advanced disease is often difficult to treat with topical and systemic therapies. Surgical resection of diseased skin has become paramount in HS management but proposes challenges of wound care and closure. Read More

G Ital Dermatol Venereol 2018 Jun;153(3 Suppl 2):20-25

Dermatology Clinic, University of Catania, Catania, Italy -

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease mainly affecting the axillary, inguinal and anogenital regions, and characterized by the presence of nodules, abscesses and sinus tracts and scarring. Clinical examination alone may underestimate the disease extension and severity. Some non-invasive skin imaging techniques such as ultrasound, magnetic resonance imaging, computed tomography, positron-emission tomography and dermoscopy, have been demonstrated to be useful in the diagnosis and management of HS. Read More

G Ital Dermatol Venereol 2018 Jun;153(3 Suppl 2):18-19

Department of Pathophysiology and Transplantation, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.

Hidradenitis suppurativa or acne inversa is an inflammatory, chronic disease of the hair follicles located in specific areas of the skin surface (axillae, submammary, inguinal and intergluteal folds, pubis, genitalia and buttocks). The diagnosis and the management of this disease are usually made by the dermatologist. However, the frequent association of hidradenitis suppurativa or acne inversa with important systemic comorbidities needs the cooperation with a number of specialists. Read More

G Ital Dermatol Venereol 2018 Jun;153(3 Suppl 2):8-17

Unit of Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy -

Hidradenitis suppurativa is a chronic, inflammatory, recurrent, debilitating skin disease characterized by recurrent abscesses, draining sinuses, and scarring, affecting principally areas of body friction. Although the disease pathogenesis is not fully understood, recent advances suggest that hidradenitis suppurativa should be viewed as a systemic inflammatory disease. Moreover, recent studies have defined hidradenitis suppurativa as a systemic disease linked to several comorbidities. Read More

G Ital Dermatol Venereol 2018 Jun;153(3 Suppl 2):3-7

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

The exact pathogenesis of hidradenitis suppurativa (HS) is still unproven. In the last few years numerous studies hypothesized that the disease is triggered by genetic and environmental factors. Follicular occlusion seems to be central to its development followed by follicular rupture, and immune responses finally leading to the development of clinical HS lesions. Read More

G Ital Dermatol Venereol 2018 Jun;153(3 Suppl 2):1-2

Department of Dermatology, ASST Spedali Civili di Brescia, University of Brescia, Brescia, Italy.

J Cutan Pathol 2018 Nov 22. Epub 2018 Nov 22.

Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York.

We report a case of disseminated Trichosporon asahii in a patient on systemic anti-fungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid-Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture. Read More

Dermatol Clin 2019 Jan 1;37(1):65-71. Epub 2018 Nov 1.

Department of Dermatology, George Washington Medical Faculty Associates, 2150 Pennsylvania Avenue Northwest, Suite 2B-427, Washington, DC 20037, USA; Department of Dermatology, George Washington School of Medicine and Health Sciences, 2150 Pennsylvania Avenue Northwest, Suite 2B-427, Washington, DC 20037, USA. Electronic address:

Comorbidities affecting dermatologic patients are of significant importance to providers and highly relevant for appropriate patient counseling, screening practices, prevention, and treatment. This article seeks to highlight several of the newest findings in the literature regarding comorbidities associated with dermatologic diseases including atopic dermatitis, hidradenitis suppurativa, alopecia areata, chronic urticaria, and the pemphigus family of immunobullous diseases. Further investigation is needed for associations between atopic dermatitis and pancreatic cancer and pemphigus family diseases and chronic obstructive pulmonary disease in order to better characterize the strength of these associations and clinical relevance. Read More

Acta Derm Venereol 2018 Nov 21. Epub 2018 Nov 21.

Department of Dermatology, hôpital Henri Mondor, Assistance Publique Hôpitaux de Paris, 51 avenue du Maréchal de Lattre de Tassigny, FR-94000 Créteil, France.

J Am Acad Dermatol 2018 Nov 17. Epub 2018 Nov 17.

Department of Dermato-Venereology & Wound Healing Centre, Bispebjerg Hospital, Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

J Am Acad Dermatol 2018 Nov 17. Epub 2018 Nov 17.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, NY. Electronic address:

Open Access Maced J Med Sci 2018 Oct 3;6(10):1902-1905. Epub 2018 Oct 3.

Department of Clinical Medicine and Surgery, Section of Dermatology and Venereology, University of Naples Federico II, Via Pansini 5, Naples, Italy.

Background: Hidradenitis suppurativa (HS) is a skin chronic inflammatory disease typically located in several areas such as perianal, inguinal and axillary regions. In 40% to 70% of cases, general practitioners (GPs) are the first health care professionals consulted by patients suffering from HS. The role of GPs in HS management could be more substantial than it has been in the past. Read More

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Treatment with apremilast has recently demonstrated clinically meaningful improvement in moderate hidradenitis suppurativa (HS).

Objective: To evaluate the change in expression of inflammatory markers in lesional skin of HS patients receiving apremilast 30 mg twice daily (n = 15) for 16 weeks compared with placebo (n = 5).

Methods: At baseline, 5-mm punch biopsies were obtained from an index lesion (HSL) and non-lesional (HSN) skin in the same anatomical area. Read More

J Eur Acad Dermatol Venereol 2018 Nov 19. Epub 2018 Nov 19.

Department of Dermatology, University Hospital of North Norway, Tromsø, Norway.

Background: Hidradenitis suppurativa (HS) substantially affects health-related quality-of-life outcomes. Most treatment options are supported by low quality of evidence without validated outcomes.

Objective: The aim of this study was to evaluate the efficacy of surgical and medical interventions using physician- and patient-reported outcomes registered in HISREG. Read More

Dtsch Med Wochenschr 2018 Nov 15;143(23):1682-1689. Epub 2018 Nov 15.

Evaluation of skin diseases can be challenging for non-dermatologists. Even obvious well-characterized skin pathologies might be misleading and thus treatment can fail. Particularly the differentiation of surgical treated entities is important, for example the management of a wound healing disturbance profoundly differs from that of a pyoderma gangrenosum. Read More

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology und Allergy, Division of Evidence-Based Medicine (dEBM)Department of Dermatology, Charité, Berlin.

In this issue, a "Critically Appraised Topic" assesses the long-term safety of clindamycin and rifampicin in hidradenitis suppurativa (HS). It concludes that the long-term use of these drugs is generally safe. As described in the CAT, the treatment approach with rifampicin was adapted from a case of dissecting cellulitis successfully treated with rifampicin as a monotherapy. Read More

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

We read with great interest the article by Albrecht et al. regarding the long-term clinical safety of Clindamycin and Rifampicin combination for the treatment of Hidradenitis Suppurativa (HS). The authors discuss carefully whether Clindamycin and Rifampicin could be safely continued beyond a 10 week course, analyzing long term toxicity of these drugs. Read More

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Laboratory of Investigative Dermatology, The Rockefeller University, New York, USA.

The precise pathogenesis of Hidradenitis Suppurativa (HS) remains unclear. Kanni et al provides novel data implicating C5a and the membrane attack complex in HS pathogenesis. This opens the possibility of therapeutic blockade of C5a for the treatment of HS, although the results do require replication in larger patient cohorts. Read More

Br J Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL.

Background: Hidradenitis suppurativa (HS) is associated with pain, disfigurement, psychosocial distress and poor quality of life, all of which may lead to higher likelihood of mental health (MH) disorders. However, little is known about the MH comorbidities of HS.

Objectives: to determine the MH disorders and cost-burden associated with HS. Read More

Allergy 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.

J Invest Dermatol 2018 Nov 8. Epub 2018 Nov 8.

The Rockefeller University, New York, NY USA.

In November 2017, a formal debate on the role of bacteria in the pathogenesis of hidradenitis suppurativa (HS) was held at the 2 Symposium on Hidradenitis Suppurativa Advances (SHSA) in Detroit, MI. In this report, we present both sides of the argument as debated at the SHSA meeting, and then discuss the potential role of bacteria as classic infectious pathogens versus an alternative pathogenic role as activators of dysregulated commensal bacterial-host interactions. While there was consensus that bacteria play a role in pathogenesis, and thus are pathogenic, there was a compelling discussion about whether bacteria in HS incite an infectious disease as we classically understand it, or whether bacteria might play a different role in HS pathogenesis. Read More

Skin Appendage Disord 2018 Oct 26;4(4):281-285. Epub 2018 Jan 26.

Division of Dermatology, University Medicine Cluster, National University Hospital, Singapore.

Background: Demographic studies of hidradenitis suppurativa (HS) in Western countries have found an association with the female gender and with co-morbidities, such as the metabolic syndrome. There are few studies in an Asian context.

Objective: This study examines the characteristics of HS at a Singaporean institute and compares them to those of existing studies in the West. Read More

J Am Acad Dermatol 2018 Nov 4. Epub 2018 Nov 4.

Department of Dermatology, Penn State College of Medicine, Hershey, Pennsylvania.

J Eur Acad Dermatol Venereol 2018 Nov 5. Epub 2018 Nov 5.

Department of Medical Sciences Section of Dermatology, University of Ferrara, Italy.

Background: Antibiotic (AB) treatment is one of the first steps in the management of Hidradenitis Suppurativa (HS). Bacteria, in HS patients, may play a double role, as triggering factors of inflammatory reactions and/or agents of infection.

Objectives: The aims of this study are: 1) to assess prevalence and AB resistance of bacterial growths in HS patients 2) assessment of the clinical relevance of obtained data in guiding the selection of the most effective AB therapy. Read More

Urology 2018 Nov 2. Epub 2018 Nov 2.

Department of Urology, The George Washington University School of Medicine and Health Sciences, Washington, DC.

Hidradenitis suppurativa is a chronic inflammatory condition affecting the axilla, genitals, perineum, and perianal regions. The pathophysiology of hidradenitis suppurativa is complex and requires a multidisciplinary approach to treatment involving medical and surgical management when indicated. We describe our multidisciplinary protocol for treatment, which includes rheumatology-monitored immunotherapy, medical management, wide surgical resection, wound care, and reconstruction. Read More

J Invest Dermatol 2018 Oct 31. Epub 2018 Oct 31.

Division of Dermatological Allergology, Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. Electronic address:

Acta Dermatovenerol Croat 2018 Oct;26(3):260-261

Valerio De Vita, MD, Young Dermatologists Italian Network (YDIN) Study Center of the Italian Group for Epidemiologic Research in Dermatology (GISED), Via Clara Maffei 4, 24121 Bergamo , Italy;

We have read with great interest the case report recently published in Acta Dermatovenerologica Croatica by Boer and Mihajlovic (1), which describes a 33-year-old woman with an 18-year history of classic hidradenitis suppurativa (HS) who developed HS-like lesions at the position of the bra strap. We agree with Boer and Mihajlovic: according to our clinical experience, we are convinced that mechanical stress may contribute or, in some cases, result in the development of HS. In this regard, we will describe the case of a patient with a monster hernia who presented HS-like lesions on his abdomen corresponding to the perihernial skin area, suggesting that mechanical stress was an important pathogenic factor for HS development. Read More

Acta Dermatovenerol Croat 2018 Oct;26(3):255-289

Ines Sjerobabski Masnec, MD, Department of Dermatology and Venereology, Sestre milosrdnice University Hospital Center , Vinogradska 29, 10000 Zagreb , Croatia;

The case of a 26-year-old male patient with perifolliculitis capitis abscedens et suffodiens (PCAS) who later developed hidradenitis suppurativa (HS) and exacerbation of acne is presented. The patient did not respond well to conventional treatment including isotretinoin and oral antibiotics. Quality of life was significantly impaired. Read More

G Ital Dermatol Venereol 2018 Oct 29. Epub 2018 Oct 29.

Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA -

Hidradenitis suppurativa, also known as acne inversa, is a chronic recurrent inflammatory disease of the skin making management challenging and continuously evolving. A large number of modalities exist aimed at quantifying the efficacy of treatment in studies on hidradenitis suppurativa. Both physician-reported and patient-reported outcomes are used as endpoints in these studies; however, the vast majority of the modalities used to survey these reported outcomes lack validation and congruence between studies. Read More