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Clin Neurol Neurosurg 2021 Jun 8;207:106751. Epub 2021 Jun 8.

Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan.

Aim: Intractable or persistent hiccups and nausea (IHN) are rarely associated with herpes zoster (HZ-IHN). We aimed to identify the clinical characteristics of HZ-IHN by comparing them with those of neuromyelitis optica spectrum disorder associated with IHN (NMOSD-IHN).

Methods: We collected 8 patients with HZ-IHN and 12 patients with NMOSD-IHN diagnosed between 2002 and 2020 from medical databases. Read More

Minerva Anestesiol 2021 Jun 8. Epub 2021 Jun 8.

Department of Anesthesiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China -

BMC Neurol 2021 May 31;21(1):214. Epub 2021 May 31.

Department of Neurology, Teikyo University School of Medicine, Kaga 2-11-1, Itabashi-ku, Tokyo, 1738605, Japan.

Background: The course of the corticobulbar tract (CBT) to the facial nucleus has been investigated by some previous studies. However, there are some unclear points of the course of the CBT to the facial nucleus. This study aimed to elucidate the detailed course of the CBT to the facial nucleus through the analysis of lateral medullary infarction (LMI) cases. Read More

J Family Med Prim Care 2021 Feb 27;10(2):1040-1043. Epub 2021 Feb 27.

Department of General Medicine, JJM Medical College, Davanagere, Karnataka, India.

Coronavirus disease (COVID-19) is the newly discovered infectious disease, affecting millions worldwide. Majority of the patients present with mild respiratory syndrome. Some neurological symptoms are reported like anosmia & dysgeusia. Read More

Rinsho Shinkeigaku 2021 May 20. Epub 2021 May 20.

Department of Neurology, Hyogo Prefectural Amagasaki General Medical Center.

A 46-year-old man developed acute meningo-encephalitis with confusion, headache, fever, intractable hiccups, dysuria, myoclonus/tremor, and ataxia. Analysis of cerebrospinal fluid (CSF) showed elevated levels of cell counts and protein. Brain MRI demonstrated multiple linear increased FLAIR signals in bilateral basal ganglia and corona radiata. Read More

A A Pract 2021 May 17;15(5):e01452. Epub 2021 May 17.

From the Department of Anesthesiology, Harbor-University of California, Los Angeles (UCLA) Medical Center, Los Angeles, California.

Increased intra-abdominal pressure (IAP) following large abdominal surgeries can lead to postoperative complications, including wound dehiscence and surgical reoperation. Numerous factors can contribute to increased postoperative IAP, and intractable hiccups have been implicated as a culprit. Different treatment modalities have been widely used with variable success in addressing intractable hiccups. Read More

Case Rep Psychiatry 2021 22;2021:5567152. Epub 2021 Apr 22.

Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 57, 56100 Pisa, Italy.

Hiccups are sudden, repeated, and involuntary contractions of the diaphragm muscle (myoclonic contraction). It involves a reflex arc that, once activated, causes a strong contraction of the diaphragm immediately followed by the closure of the glottis translating into the classic "hic" sound. Hiccups can be short, persistent, and intractable depending on the duration. Read More

Dev Med Child Neurol 2021 May 10. Epub 2021 May 10.

Research Unit iDN, Interdisciplinary Developmental Neuroscience, Division of Phoniatrics, Medical University of Graz, Graz, Austria.

The study of the onset and ontogeny of human behaviour has made it clear that a multitude of fetal movement patterns are spontaneously generated, and that there is a close association between activity and the development of peripheral and central structures. The embryo starts moving by 7.5 week's gestation; 2 to 3 weeks later, a number of movement patterns including general movements, isolated limb and head movements, hiccup, and breathing movements, appear. Read More

J Neurosci Rural Pract 2021 Apr 1;12(2):431-434. Epub 2021 Apr 1.

Department of Internal Medicine, Yashoda Superspeciality Hospital, Malakpet, Hyderabad, Telangana, India.

Neuromyelitis optica spectrum disorders (NMOSDs) usually manifest with features of long-segment myelitis and/or optic neuritis. Area postrema involvement presents with nausea, vomiting, and intractable hiccups. Cerebral cortical involvement is a relatively uncommon phenomenon. Read More

J Glob Infect Dis 2021 Jan-Mar;13(1):52-55. Epub 2021 Jan 29.

Department of Microbiology, Dr. Rela Institute and Medical Centre, Chennai, Tamil Nadu, India.

Melioidosis is an endemic bacterial infection caused by soil saprophyte, . It infects adults with risk factors or immunosuppressed and exposed to moist soil. Its significance lies in its varied clinical presentation and high mortality (40%). Read More

Pharm Biol 2021 Dec;59(1):484-493

Institute of Drug Clinical Trials, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Context: Capsule of alkaloids from the leaf of (L.) R.Br. Read More

JAMA 2021 Apr;325(14):1385

Cureus 2021 Mar 6;13(3):e13730. Epub 2021 Mar 6.

Otolaryngology - Head and Neck Surgery, Mayo Clinic, Jacksonville, USA.

Hiccup is a common phenomenon experienced by almost everyone in life. Although the exact physiology of this phenomenon remains unknown, it is associated with multiple central and peripheral etiologic causes. Vocal fold granulomas are benign laryngeal lesions typically caused by iatrogenic trauma, voice misuse, or chronic irritation. Read More

J Med Case Rep 2021 Apr 9;15(1):194. Epub 2021 Apr 9.

Division of Surgical Oncology-Department of Surgery, Dr. Sardjito Hospital/Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Jl Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Background: Esophageal involvement and Horner's syndrome are rare manifestations of breast cancer distant metastases that can pose a significant challenge in diagnosis and treatment. In addition to the more aggressive behavior of breast cancer diagnosed in young women, non-adherence to treatment is associated with increased risk of distant metastasis.

Case Presentation: A 36-year-old Javanese woman presented to our institution with dysphagia, hoarseness, and frequent hiccups. Read More

J Integr Neurosci 2021 Mar;20(1):247-254

Department of Pharmacology, College of Medicine and Health Science, Khalifa University of Science and Technology, 127788 Abu Dhabi, United Arab Emirates.

The hiccup (Latin ) is an involuntary periodic contraction of the diaphragm followed by glottic closure, which can be a rare side effect of aripiprazole. In contrast to the structurally closely related aripiprazole, brexpiprazole was not associated with this particular adverse drug reaction. Having two very similar drugs that differ in their ability to induce hiccups represents a unique opportunity to gain insight into the receptors involved in the pathophysiology of the symptom and differences in clinical effects between aripiprazole and brexpiprazole. Read More

Cureus 2021 Mar 1;13(3):e13625. Epub 2021 Mar 1.

Infectious Diseases, Saint Michael's Medical Center, Newark, USA.

Sudden, involuntary spasm of the diaphragm associated with closure of the glottis will lead to a hiccup sound. Brief episodes of hiccups are often self-limiting and may be physiologically encountered in everyday life. However, prolonged attacks of hiccups are associated with significant morbidity. Read More

Noro Psikiyatr Ars 2021 Mar 16;58(1):77-78. Epub 2021 Jan 16.

Department of Child and Adolescent Psychiatry, Mersin University Medical Faculty, Mersin Turkey.

Neurotransmitters and neuroreceptors involved in the pathophysiology of hiccups are not well defined. However, dopamine and serotonin are reported to have roles in activating hiccups, and recent case reports suggest that some psychopharmacologic medications -such as antipsychotics- may trigger hiccups in many cases. Our case describes the activation of hiccups in a young male with schizophrenia while being treated with aripiprazole. Read More

Am J Trop Med Hyg 2021 Apr 1. Epub 2021 Apr 1.

7Department of Cardiology, Istanbul Aydın University, Istanbul, Turkey.

Two cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded only to chlorpromazine. COVID-19 patients may present with hiccups and also may have hiccups after treatment. Read More

Am J Hosp Palliat Care 2021 Apr 1:10499091211006923. Epub 2021 Apr 1.

Department of Oncology, Mayo Clinic, Rochester, MN, USA.

Background: Cancer patients are at risk for hiccups, but the incidence and impact on quality of life are unclear.

Methods: A survey (modified from the Functional Living Index with the inclusion of qualitative elements) was developed and launched on an 80,000-member medical social media platform, Mayo Clinic Connect https://connect.mayoclinic. Read More

eNeurologicalSci 2021 Jun 8;23:100335. Epub 2021 Mar 8.

Department of Neurology, Chibaken Saiseikai Narashino Hospital, 1-1-1 Izumi-cho, Narashino City, Chiba 275-8580, Japan.

Hiccups, nausea and vomiting are known as the clinical manifestations of neuromyelitis optica spectrum disorder (NMOSD) linked to lesions of the area postraema in the medullary tegmentum. Here, we describe a 74-year-old male patient with NMOSD who presented with recurrent syncope due to severe orthostatic hypotension (OH) following symptoms of hiccups, nausea and vomiting. Brain magnetic resonance imaging revealed the lesion of the area postraema and it could be responsible for the symptom of OH. Read More

BMC Neurol 2021 Mar 9;21(1):109. Epub 2021 Mar 9.

Neuroscience Center, General Hospital of Ningxia Medical University, Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Yinchuan, 75004, China.

Background: Neuromyelitis optica spectrum disorders (NMOSD), a group of autoimmune neurological diseases, involve the optic nerve, spinal cord, and brain. Meningitis is rarely reported as the primary clinical manifestation of both anti-aquaporin-4 (AQP4)/ anti-myelin oligodendrocyte glycoprotein (MOG) antibody-negative NMOSD (NMOSD).

Case Presentation: A 30-year-old man initially presented with fever, headache, and neck stiffness. Read More

Support Care Cancer 2021 Mar 16. Epub 2021 Mar 16.

Palliative Care Team, Seirei Mikatahara General Hospital, Hamamatsu, Japan.

Purpose: The aims of this study were to examine the prevalence of myoclonus, sweating, pruritus, hiccup, and vesical and rectal tenesmus, and to explore associated factors in patients with advanced cancer.

Methods: This multicenter prospective cohort study was conducted in 23 inpatient hospices/palliative care units in Japan from January to December 2017. The prevalence and characteristics of each symptom were assessed on admission and in the 3 days before death. Read More

J Neurol Surg B Skull Base 2021 Feb 4;82(Suppl 1):S2-S3. Epub 2020 Mar 4.

Department of Neurosurgery, University of Insubria, Ospedale di Circolo Fondazione Macchi, Varese, Italy.

 We illustrate endoscopic endonasal odontoidectomy for the Chiari-I malformation respecting craniovertebral junction (CVJ) stability.  Case report of a 12-year-old girl affected by the Chiari-I malformation. Magnetic resonance imaging (MRI) showed tonsillar herniation, basilar invagination, and dental retroversion, causing angulation and compression of the bulbomedullary junction. Read More

Eurasian J Med 2021 Feb 19;53(1):2-4. Epub 2021 Jan 19.

Department of Respiratory Medicine, Mito Medical Center, University of Tsukuba-Mito Kyodo General Hospital, Mito, Ibaraki, Japan.

Objective: Shakuyakukanzoto, one of the traditional herbal medicines commonly used in North-East Asian countries, is known to be effective for muscle cramps. This retrospective study aimed to evaluate the effect of shakuyakukanzoto on chemotherapy-induced metoclopramide-uncontrolled hiccups.

Materials And Methods: We retrospectively investigated the medical records of all the consecutive patients with lung cancer who were prescribed with shakuyakukanzoto (Tsumura Co. Read More

Acc Chem Res 2021 04 11;54(8):1817-1829. Epub 2021 Mar 11.

Department of Chemistry, University of Rochester, 120 Trustee Road, Rochester New York 14611, United States.

Total synthesis has long been depicted as the quest to conquer the structures created by nature, requiring an unflinching, single-minded devotion to the task. The goal is achieved by chemists with grit, strength of will, and a competitive spirit. While there is some truth to this viewpoint, it does not fully capture the rich experiences gained in this research realm. Read More

Trans R Soc Trop Med Hyg 2021 Mar 9. Epub 2021 Mar 9.

Nawaloka Hospital Research and Education Foundation, Nawaloka Hospitals, Colombo 02, Sri Lanka.

In recent times, star fruit (Averrhoa carambola) nephrotoxicity and neurotoxicity have been increasingly reported, both in individuals with pre-existing renal disease and those with previously normal renal function. We summarise the clinical findings of star fruit toxicity in humans and outline the important pathogenetic insights provided by animal studies. Google Scholar, EMBASE, Scopus and PubMed were searched from 1995 through July 2020 for case reports/series on renal or neurological manifestations of star fruit toxicity in humans and mechanisms of star fruit toxicity in animal studies. Read More

Front Med (Lausanne) 2021 22;8:629828. Epub 2021 Feb 22.

Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

We reported that the complete genome sequence of SARS-Coronavirus-2 (SARS-CoV-2) was obtained from a cerebrospinal fluid (CSF) sample by ultrahigh-depth sequencing. Fourteen days after onset, seizures, maxillofacial convulsions, intractable hiccups and a significant increase in intracranial pressure developed in an adult coronavirus disease 2019 patient. The complete genome sequence of SARS-CoV-2 obtained from the cerebrospinal fluid indicates that SARS-CoV-2 can invade the central nervous system. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24879

The Fourth Department of Acupuncture and Moxibustion, Shaanxi Traditional Chinese Medicine Hospital, Xi'an.

Background: Persistent and intractable hiccups are a common clinical symptom that cause considerable physical pain to patients and severely damage their quality of lives. An increasing number of studies have demonstrated that acupuncture applied at acupoints dominated by Cuanzhu (BL2) can be used as one of the nonpharmacological therapies for controlling intractable hiccups. However, there is insufficient evidence evaluating the safety and effectiveness of those interventions. Read More

J Cardiovasc Nurs 2021 Feb 28. Epub 2021 Feb 28.

Ingela Thylén, PhD, RN Associate Professor, Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University, Sweden. Tiny Jaarsma, PhD, RN Professor, Department of Health, Medicine and Caring Sciences, Linköping University, Sweden. Brynja Ingadottir, PhD, RN Assistant Professor, Faculty of Nursing, School of Health Sciences, University of Iceland, Reykjavik, Iceland and Clinical Nurse Specialist, Landspitali University Hospital, Reykjavik, Iceland.

Background: Little is known about risk factors for poor adjustment to the device after cardiac resynchronization therapy (CRT) implantation in patients with heart failure.

Purpose: The aim of this study was to explore device adjustment and the postoperative recovery of patients with heart failure undergoing elective CRT device implantation.

Methods: In this prospective multicenter longitudinal study, data were collected before implantation and after 2 weeks, 6 months, and 1 year, using validated self-reported instruments and investigator-designed, CRT-specific questions. Read More

Cureus 2021 Jan 28;13(1):e12974. Epub 2021 Jan 28.

Internal Medicine, Aga Khan University, Nairobi, KEN.

Hiccups, involuntary contraction of the diaphragm and intercostal muscle followed by an abrupt closure of the glottis, are a bothersome symptom that can be caused by a variety of illnesses or medications. Hiccups that persist for more than 48 hours should raise the suspicion of an underlying cause. Pneumonias, especially caused by the novel coronavirus, have rarely been reported to trigger hiccups. Read More