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Am J Emerg Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:

Hiccups are usually benign, while myocardial infarction (MI) has the potential for morbidity and mortality. Here, we report 3 cases of MI, with hiccups being the only symptom on presentation to the emergency department. Attention should be given to patients who present with hiccups and multiple risk factors for acute coronary syndrome, especially those with factors predisposing them to atypical presentations, such as diabetes mellitus, and old age. Read More

Biomed Pharmacother 2019 Apr 10;114:108838. Epub 2019 Apr 10.

Department of Palliative Medicine, Poznan University of Medical Sciences, Poland.

Purpose: The undesired effects of midazolam can be life-threatening. This paper delineates the findings related to the pharmacokinetics, adverse effects and drug-drug interactions as well as associated therapeutic implications for safe midazolam use.

Methods: A systematic review of literature was conducted. Read More

BMC Neurol 2019 Apr 10;19(1):58. Epub 2019 Apr 10.

Faculte des Sciences de la Sante, Universite de Lome, BP 1515, Lome, Togo.

Background: Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populations have shown that NMOSDs disproportionately affect black people with relatively more frequent encephalic involvement. Read More

Psychiatr Danub 2019 Mar;31(1):26-31

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy,

Aripiprazole is an interesting psychoactive compound acting as a dopamine D2 partial agonist, serotonin 5-HT(1A) partial agonist and serotonin 5-HT(2A) antagonist. Aripiprazole possesses a well-documented efficacy in the treatment of both positive and negative psychotic symptoms. However, this medication may be rarely associated with the onset of hiccup. Read More

Yakugaku Zasshi 2019 ;139(4):647-650

Department of Pharmacy, Agano City Hospital.

The effectiveness of steroid rotation from dexamethasone to prednisolone for hiccups caused by dexamethasone for antiemetic chemotherapy has been reported overseas, but has not been reported in Japan. The effectiveness of steroid rotation in Japanese individuals is unclear because ethnic differences and variations in glucocorticoid receptors affect sensitivity to dexamethasone. We report a case of the effectiveness of steroid rotation in a Japanese patient with hiccups caused by dexamethasone for antiemetic chemotherapy. Read More

Clin Respir J 2019 Mar 26. Epub 2019 Mar 26.

Department of Pharmacology & Cell Biology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida.

The recent report in this journal by Toshiro Obuchi et al on CO retention stands out among the many published attempts at offering a solution for an annoying and potentially dangerous symptom, the obstinate hiccup. The authors manage to provide not only a target-guided therapeutic approach (i.e. Read More

Pediatr Blood Cancer 2019 Jun 21;66(6):e27690. Epub 2019 Mar 21.

Merck & Co., Inc., Kenilworth, New Jersey.

Background: Current antiemetic regimens are less effective in children than in adults. Fosaprepitant was recently approved for prevention of chemotherapy-induced nausea and vomiting (CINV) in children aged six months and older.

Procedure: The pharmacokinetic (PK)/pharmacodynamic (PD) profile, safety, and tolerability of a single intravenous dose of fosaprepitant administered concomitantly with ondansetron with/without dexamethasone were evaluated in pediatric patients with cancer receiving emetogenic chemotherapy. Read More

Acupunct Med 2019 Mar 7:acupmed2016011304. Epub 2019 Mar 7.

1 Department of Orthopaedics, Changzhou Traditional Chinese Medical Hospital, Changzhou, Jiangsu Province, China.

Objective:: There are multiple treatment options for hiccups, including non-pharmacological therapies, but little evidence of superiority of one treatment over another. The aim of this study was to investigate the effects of acupuncture on persistent hiccups after arthroplasty.

Methods:: From April 2010 to December 2015, 15 patients with primary unilateral total hip/knee arthroplasty were diagnosed with persistent hiccups and given acupuncture at PC6, CV12 and ST36. Read More

J Clin Anesth 2019 Mar 2;57:7-8. Epub 2019 Mar 2.

General Practitioner, Emam Khomeini Hospital, Urmia University of Medical Science, Urmia, Iran.

Rinsho Shinkeigaku 2019 Mar 28;59(3):139-143. Epub 2019 Feb 28.

Department of Neurology, Osaka City General Hospital.

A 52-year old woman first noted dysphagia four months before admission followed by dysarthria two months later. She then developed weakness of all limbs and became unable to walk. All these symptoms, associated with tongue atrophy, slowly progressed, leading to the initial clinical impression of a motor neuron disease, although her nerve conduction study and electromyography showed no abnormalities. Read More

Curr Probl Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Medical Oncology, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, PR China. Electronic address:

Background: Cisplatin is one of the most effective chemotherapeutic drugs for patients with advanced non-small-cell lung cancer (NSCLC). Single high-dose cisplatin is a commonly used chemotherapy regimen in the world. At present, fractionated doses cisplatin is used in most hospitals in China. Read More

Sci Rep 2019 Jan 30;9(1):943. Epub 2019 Jan 30.

Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

To provide useful information for diagnosing and predicting fetal intraabdominal extralobar pulmonary sequestration (IEPS), a retrospective review of diagnostic approaches was conducted. Ultrasonography was performed serially in 21 fetuses with IEPS from 2005 to 2017. Prenatal sonographic features, treatment, and outcomes of each case were evaluated and collected. Read More

J Ethnopharmacol 2019 Apr 25;233:218-233. Epub 2019 Jan 25.

National Innovation Foundation-India (Autonomous Body of Department of Science and Technology, Govt. of India), Grambharti, Amarapur, Gandhinagar, Gujarat 382650, India. Electronic address:

Ethnopharmacological Relevance: Ensete superbum (Roxb.) Cheesman. (Family: Musaceae), commonly known as "Wild Banana" is well recorded as popular ethnomedicine for medicinal and nutritional uses by different people and communities native to India, Ethiopia, Thailand, Myanmar and Vietnam. Read More

Neurohospitalist 2019 Jan 5;9(1):37-40. Epub 2018 Jul 5.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.

The occurrence of amyotrophic lateral sclerosis (ALS) and neuromyelitis optica (NMO) in a single patient is exceedingly rare. We report a case of a 54-year-old woman of East Asian descent with a prior diagnosis of ALS who developed an episode of unexplained hiccups and nausea and vomiting consistent with area postrema syndrome 3 months prior to the onset of acute transverse myelitis. Magnetic resonance imaging revealed abnormal T2 hyperintensity and gadolinium enhancement at the cervicomedullary junction with extension to C3. Read More

Zhonghua Yi Xue Za Zhi 2019 Jan;99(4):295-300

Department of Gastroenterology, Lanzhou University Second Hospital, Lanzhou 730000, China.

To explore the efficacy of Jinghuaweikang capsules combined with Quadruple therapy in the treatment of ()infection. Patients who were infected with in 7 centers in Gansu Province were recruited in this prospective simple randomized study. All the patients are divided into four groups randomly: patients in Group A1 were treated with esomeprazole (20 mg, twice a day) + pectin bismuth (200 mg, three times a day) + amoxicillin (1 000 mg, twice a day) + clarithromycin (500 mg, twice a day), while Group A2 with Jinghuaweikang capsules(160 mg, three times a day) based on group A2, Group B1 with esomeprazole (20 mg, twice a day) + bismuth pectin (200 mg, three times a day) + amoxicillin (1 000 mg, twice a day) + furazolidone (100 mg, twice a day) and Group B2 with Jinghuaweikang capsules(160 mg, three times a day) based on group B2. Read More

Invest New Drugs 2019 Jan 9. Epub 2019 Jan 9.

Eisai Co. Ltd., Tokyo, Japan.

Background We conducted a first-in-Japanese, phase I study of ontuxizumab, a humanized, anti-endosialin monoclonal antibody, to confirm its tolerability, safety, and pharmacokinetics, and identify exploratory efficacy. Methods This was a multicenter, multiple-dose, open-label study in Japanese patients aged ≥20 years with solid tumors, including gastric cancer (GC) or advanced hepatocellular carcinoma (HCC), who had failed standard chemotherapy. The study comprised two parts: part 1 (dose-escalation; ontuxizumab 2-12 mg/kg weekly) and part 2 (cohort-expansion; 4 or 8 mg/kg weekly, or 12 mg/kg biweekly). Read More

Adv Biomed Res 2018 27;7:146. Epub 2018 Nov 27.

Department of Anesthesiology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: This study aimed to evaluate and compare the therapeutic effects of ephedrine and lidocaine in treatment of intraoperative hiccups in gynecologic surgery under sedation.

Materials And Methods: This randomized clinical trial in Isfahan was done on fifty female patients referring to Shahid Beheshti Hospital who needed to have sedation for medical interventions and they afflicted hiccups during surgery or sedation. Patients divided into two groups of 25 randomly assigned to one of the two groups of ephedrine or lidocaine. Read More

Surg Neurol Int 2018 26;9(Suppl 4):S85-S90. Epub 2018 Nov 26.

División Neurocirugía, Hospital De Niños Ricardo Gutiérrez, Ciudad De Buenos Aires, Argentina.

Objective: To describe the case of a pediatric patient with a giant vertebral artery aneurysm treated with microsurgical clipping.

Materials And Methods: Sixteen patients were treated in our institution in the past 5 years. Only two cases were vertebral artery aneurysms. Read More

PLoS One 2018 27;13(12):e0209655. Epub 2018 Dec 27.

Save the Children International, Kerry Town, Sierra Leone.

Background: While a number of predictors for Ebola mortality have been identified, less is known about post-viral symptoms. The identification of acute-illness predictors for post-viral symptoms could allow the selection of patients for more active follow up in the future, and those in whom early interventions may be beneficial in the long term. Studying predictors of both mortality and post-viral symptoms within a single cohort of patients could also further our understanding of the pathophysiology of survivor sequelae. Read More

Gan To Kagaku Ryoho 2018 Dec;45(12):1751-1753

Dept. of Surgery, Tokai Memorial Hospital.

A 72-year-old man presented to our hospital with a chief complaint of constipation and hiccup. Computed tomography revealed a colonic obstruction due to descending colon cancer, and a transnasal ileus tube was inserted. On the 2nd day of hospitalization, we attempted transanal drainage, but it was difficult to cannulate. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Internal Medicine E, Emek Medical Center, Afula, Israel.

A 71-year-old patient was admitted due to fever and persistent (>48 hours) hiccups. History and physical examination were not instructive. Lab tests were not specific, showing an inflammatory response. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13712

Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Rationale: Currently, the mainstream treatment for gastric bezoars is endoscopic lithotripsy. This report describes traditional Chinese medicine (TCM) purgative cured a 62-year-old woman with a huge gastric bezoar accompanied by isolated esophageal venous aneurysms and multiple bleeding gastric ulcers.

Patient Concerns: A 62-year-old woman with several symptoms, including epigastric pain, nausea, and vomiting, hiccups, heartburn, and dark, loose stools. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13667

Rationale: Sarcoidosis is a multisystem disorder characterized by noncaseating granulomas. The nervous system is involved in 5 to 16% of the patients. However, neurosarcoidosis in the medulla oblongata presenting as hiccough is remarkably rare. Read More

BMC Nephrol 2018 Dec 11;19(1):352. Epub 2018 Dec 11.

Intern Doctor, Internal Medicine Department, An-Najah National University Hospital, Nablus, Palestine.

Background: Baclofen is a centrally acting GABA receptor agonist and it is used widely for the treatment of spasticity, persistent hiccups and multiple sclerosis. The renal system is the main route of excretion, thus people with suboptimal renal function are prone to baclofen intoxication. Multiple doses of baclofen have been associated with toxicity, but it is very unusual that single dose can do so. Read More

Aust N Z J Psychiatry 2018 Dec 11:4867418816823. Epub 2018 Dec 11.

1 The Clinical Neuromodulation Laboratory, Santa Casa School of Medical Sciences, São Paulo, Brazil.

Front Psychiatry 2018 23;9:626. Epub 2018 Nov 23.

Section of Psychiatry, Department of Medicine and Surgery, University of Insubria, Varese, Italy.

"Medically Unexplained Physical Symptoms" (MUPS) defines a subgroup of patients presenting physical symptoms of unclear origin. The study aims to profile clinical and socio-demographic characteristics of patients with MUPS. This 9-years observational retrospective study assesses all patients admitted between 2008 and 2016 in the divisions of neurology and gastroenterology. Read More

Caspian J Intern Med 2018 ;9(4):403-405

1. 2 Department of Internal Medicine, General Hospital of Heraklion "Venizeleio-Pananeio", Leoforos Knossou, Heraklion, Greece.

Background: Persistent hiccups can be a debilitating symptom and many such patients present to the emergency department seeking relief. A variety of serious conditions have been associated with persistent hiccups. Cases of pneumonia as a cause of hiccups have been rarely described. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13370

Rationale: Although persistent postoperative hiccups can cause various problems (such as sleep disorders, depression, fatigue) for the patient, there has been little research on this topic. The purpose of this study is to determine the effectiveness of treating persistent postoperative hiccups with a stellate ganglion block (SGB), an injection of local anesthetic in the sympathetic nerve tissue of the neck.

Patient Concerns And Diagnoses: Three patients each developed persistent hiccups within 3 days of abdominal surgery, lasting for 3 to 6 days. Read More

Prim Care Companion CNS Disord 2018 11 22;20(6). Epub 2018 Nov 22.

Eur J Oncol Nurs 2018 Dec 19;37:23-28. Epub 2018 Oct 19.

Department of Nursing, Inha University, Incheon, Republic of Korea. Electronic address:

Purpose: The purpose of this study was to identify demographic, health- and cancer-related, and physiological factors associated with dexamethasone-induced intractable hiccups in cancer patients.

Method: This study adopted a retrospective case control design. The study subjects were 168 cancer patients admitted to a university hospital for chemotherapy between October 2011 and December 2016: 58 patients who experienced intractable hiccups while on dexamethasone (cases) and 110 matched patients who received dexamethasone but did not experience hiccups (controls). Read More

Mult Scler 2019 Mar 22;25(3):325-329. Epub 2018 Nov 22.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

In this topical review, we discuss the history of the area postrema syndrome, with special attention given to early studies aimed at identifying the area postrema and its function, possible early cases of the syndrome and its current relevance in neuroimmunology and demyelinating diseases. In 1896, Retzius named a structure in the posterior medulla oblongata as the area postrema. The work of Borison in the middle of the 20th century led to the elucidation of its function as a "vomiting center. Read More

J Craniovertebr Junction Spine 2018 Jul-Sep;9(3):212-215

Department of Orthopaedics, Nemours/Alfred I. Dupont Hospital for Children, Wilmington, Delaware, USA.

Basilar impression is a cranial base abnormality associated with osteogenesis imperfecta (OI) with serious neurologic implications but controversial treatment options. Combined anterior and posterior decompression with long-segment posterior fusion is often recommended. We report a patient with OI (Sillence type III) with basilar impression treated with halo traction followed by posterior surgery. Read More

Case Rep Emerg Med 2018 10;2018:5023954. Epub 2018 Oct 10.

Department of Emergency Medicine, University Hospitals Cleveland Medical Center & Case Western Reserve University, Cleveland, OH 44106, USA.

We report the case of a person who went into cardiac arrest after being given chlorpromazine for hiccups and was subsequently diagnosed with congenital Long QT Syndrome. Long QT Syndrome is an uncommon, congenital condition that carries a high risk of sudden cardiac death. Clinicians need to recognize the risk that chlorpromazine may prolong the QTc and prepare to manage potential complications. Read More

Clin Neuropharmacol 2019 Jan/Feb;42(1):17-18

Department of Child and Adolescent Psychiatry, Meram School of Medicine, Necmettin Erbakan University, Konya, Turkey.

Hiccup is a sudden-onset repeated involuntary and spasmodic contraction of the diaphragm and intercostal muscle accompanied by laryngeal closure, generating the characteristic inspiratory sound and discomfort. Various factors including drugs may trigger the hiccups. There are some reports regarding the possible links between psychotropic agents that can affect the dopaminergic system and the triggering of hiccup; however, to our knowledge, there are no data regarding sertraline-induced hiccup. Read More

Int Med Case Rep J 2018 11;11:263-264. Epub 2018 Oct 11.

Department of Anesthesiology, Mayo Clinic Hospital, Phoenix, AZ, USA,

Singultus (hiccups lasting longer than 48 hours) is a described complication following epidural steroid injections, sacroiliac joint injections, and facet joint injections. The underlying etiology is not completely understood, but it is a condition that can be distressing to patients. Our case presentation involves a 62-year-old male presenting for cervical epidural steroid injection. Read More

Nihon Shokakibyo Gakkai Zasshi 2018;115(10):898-904

Department of Health Care, Kyoto Okamoto Memorial Hospital.

A 58-year-old male receiving two types of antithrombotic medication developed acute obstructive suppressive cholangitis due to choledocholithiasis. During the first endoscopic retrograde cholangiopancreatography (ERCP) procedure, we performed biliary plastic stenting. Seven days after this procedure and with continued antithrombotic treatment, we performed ERCP with endoscopic sphincterotomy and stone extraction. Read More

Niger J Clin Pract 2018 Oct;21(10):1356-1360

Department of Emergency Medicine, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.

Background: Although little importance is attached to hiccups, they may be associated with several diseases. The purpose of this study was to investigate the effects of gender differences on types of hiccups and the relation with diseases involved in the etiology.

Materials And Methods: Patients presenting to the Kirikkale University Medical Faculty Hospital with hiccups were investigated retrospectively. Read More

Neurology 2018 Oct 26;91(17):e1642-e1651. Epub 2018 Sep 26.

From the Departments of Neurology (E.S., D.D., M.M., E.F., A.G., B.W., S.J.P.), Laboratory Medicine and Pathology (M.M., E.F., A.G., S.J.P.), and Clinical Research Unit (C.H., J.S.), Mayo Clinic College of Medicine, Rochester, MN; Nuffield Department of Clinical Neurosciences (J.P., M.I.L., S.M.), Oxford; The Walton Centre (A.J., D.W., L.E.), NHS Foundation Trust, Liverpool, UK; Department of Neurology (I.N., K.F., T.T., T.M., Y.T.), Tohoku University Graduate School of Medicine, Sendai; Department of Multiple Sclerosis Therapeutics (K.F.), Fukushima Medical University School of Medicine and Multiple Sclerosis and Neuromyelitis Optica Center, Southern Tohoku Research Institute for NeuroScience, Koriyama, Japan; Department of Neurology (M.L., A.B.), Johns Hopkins University, Baltimore, MD; Departments of Neurology and Neurotherapeutics (B.M.G.), UT Southwestern Medical Center, Dallas, TX; Department of Neurology (T.T.), Yonezawa National Hospital; and Department of Neurology (I.N.), Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Objective: To define the frequency, duration, and severity of intractable nausea, vomiting, or hiccups in aquaporin-4-immunoglobulin G (AQP4-IgG)-positive neuromyelitis optica spectrum disorder (NMOSD) and propose diagnostic criteria and a severity scale for area postrema syndrome (APS).

Methods: An International NMOSD database was interrogated for frequency of APS. Patients with AQP4-IgG-positive NMOSD completed an APS symptom questionnaire. Read More

Tomography 2018 Jun;4(2):43-45

Department of Physical Therapy, Adventist University of Health Sciences, Orlando, FL.

Prenatal ultrasonography in the early third trimester showed an unusual branching pattern of the right aortic arch. Echocardiography performed 4 h after birth showed the right aortic arch with mirror-image branching, patent ductus arteriosus, and patent foramen ovale. Because the location of the ductus arteriosus was unclear on echocardiography, cardiovascular magnetic resonance imaging was performed 3 days after birth. Read More

Caspian J Intern Med 2018 ;9(3):299-302

Bulent Ecevit University, School of Medicine, Department of Cardiology, Zonguldak, Turkey.

Background: Lead-related infections that might develop after pacemaker implantation associated with high mortality and morbidity rates are challenging to manage and pose high-cost. Patients with lead-related infections usually present with fever, chills and fatigue and the treatment can be challenging unless the implant system is extracted.

Case Presentation: A 66-year old male patient who underwent dual chamber pacemaker and implantable cardioverter defibrillator was admitted to the emergency service with a six-week history of complaints of hiccups and fever. Read More

BMC Anesthesiol 2018 09 5;18(1):123. Epub 2018 Sep 5.

Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, 16# Jichang Road, Guangzhou, 510405, China.

Background: Continuous hiccups during surgery not only affect the surgical procedure, they can also cause adverse effects for the patient. Apart from active investigation of the cause of the hiccups, their timely termination is also necessary.

Case Presentation: We reported a case of a 70-year-old woman with continuous intraoperative hiccups that appeared during vaginal hysterectomy under low continuous epidural anesthesia. Read More

J Clin Anesth 2019 02 31;52:50. Epub 2018 Aug 31.

Department of Anesthesiology and Perioperative Medicine, University of Missouri, United States of America.

Brain Stimul 2018 Nov - Dec;11(6):1385-1387. Epub 2018 Aug 16.

Division of Neurosurgery, Department of Surgery, Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, M5T 2S8, Ontario, Canada; Krembil Brain Institute, 399 Bathurst Street, Toronto, M5T 2S8, Ontario, Canada. Electronic address:

Am J Emerg Med 2018 Nov 17;36(11):2135.e1-2135.e5. Epub 2018 Aug 17.

Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Gangrenous cholecystitis (GC) is a serious complication of acute cholecystitis that has been associated with increased morbidity. Patient with GC can present with a wide variety of non-specific clinical, laboratory, and imaging characteristics, making the diagnosis challenging. This disease requires emergent treatment, which is why a quick and reliable diagnosis is essential for the wellbeing of the patient. Read More

Medicine (Baltimore) 2018 Aug;97(34):e11934

Rationale: Pathophysiologic mechanisms of the central nervous system, such as stroke, can be associated with intractable hiccups. Intractable hiccups can be associated with potentially fatal consequences, thus requiring safe management in an inpatient rehabilitation facility (IRF) setting with a multidisciplinary team approach to optimize mobility and feeding.

Patient Concerns: A 49-year-old male presented to the emergency department with complaints of vomiting and dizziness. Read More

J Thorac Dis 2018 Jun;10(6):3622-3626

Department of Thoracic Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Background: In a previous article we reported the time that hiccups stop as the instant when CO levels in both expiratory gas (EtCO) and inspiratory gas (InspCO) reach approximately 50 mmHg. To support our findings, in this article we aim to clarify the precise values of the CO level in arterial blood (PaCO) and venous blood (PvCO) during plastic bag rebreathing.

Methods: A healthy male volunteer was asked to perform a rebreathing experiment using a 20 L air-filled plastic bag. Read More

Gan To Kagaku Ryoho 2018 Jun;45(6):985-987

Dept. of Pharmacy, Hitachi General Hospital.

A 50s man receiving dialysis for chronic kidney disease due to IgA nephropathy underwent laparoscopic reversal via Hartmann 's procedure for rectal cancer and multiple liver metastases, followed by chemotherapy for the liver metastases. Following a single course of mFOLFOX therapy, bevacizumab was administered for 8 courses, resulting in tumor shrinkage and a decrease in tumor marker levels. The initial doses were 60mg/m2 oxaliplatin and 280(bolus injection)and 1,680mg/m2 (continuous infusion)of 5-FU. Read More

World Neurosurg 2018 Oct 17;118:329-331. Epub 2018 Jul 17.

Department of Neurosurgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China.

Background: The authors report the case of a 34-year-old man who presented with intractable hiccups. The imaging examination showed that the patient was suffering from syringomyelia associated with Chiari type I malformation.

Case Descriptions: The patient underwent posterior fossa decompression combined with bilateral tonsillectomy and duroplasty. Read More

BMJ Open 2018 Jul 6;8(7):e020031. Epub 2018 Jul 6.

Department of Paediatrics, Child Health and Youth Health, University of Auckland, Auckland, New Zealand.

Objective: To report perception of fetal movements in women who experienced a stillbirth compared with controls at a similar gestation with a live birth.

Design: Case-control study.

Setting: 41 maternity units in the UK. Read More