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Surg Endosc 2020 Jun 16. Epub 2020 Jun 16.

Department of Surgery, Northshore University HealthSystem, GCSI Suite B665, 2650 Ridge Ave, Evanston, IL, 60201, USA.

Introduction: The Endoluminal Functional Lumen Imaging Probe (Endoflip™) is a balloon-based catheter that provides real-time, objective feedback regarding the distensibility of any sphincter in the gastrointestinal tract. Usage of the Functional Lumen Imaging Probe (FLIP) has not been standardized, which has limited the interpretation and generalizability of published data. The purpose of this consensus statement is to provide a standardized protocol for obtaining FLIP measurements in order to create a more uniform approach to data collection. Read More

Am Surg 2020 Apr;86(4):e173-e174

Indian J Nucl Med 2020 Apr-Jun;35(2):147-153. Epub 2020 Mar 12.

Department of Nuclear Medicine, Taleghani Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Myocardial perfusion single-photon emission computed tomography (SPECT) as a common imaging procedure in nuclear medicine laboratories may encompass findings in the heart or beyond it, in the thorax or abdomen, which may be related or unrelated to the symptoms of the patients. Sometimes, these findings may be discovered incidentally. In the present article, it is aimed to present some less frequent cardiac and extracardiac findings including radiolabeled emboli, transposition of great arteries, breast prosthesis, breast tissue uptake, pericardial effusion, hiatal hernia, hepatocellular carcinoma, ascites, aortic aneurysm, splenomegaly, and polycystic kidney disease during Tc-methoxyisobutylisonitrile myocardial perfusion SPECT with their radiological correlates. Read More

J Surg Res 2020 Aug 11;252:216-221. Epub 2020 Apr 11.

Division of Endocrine Surgery, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address:

Background: The addition of SPECT-CT to Tc-99 sestamibi has become a valuable tool for parathyroid localization in primary hyperparathyroidism (PHP). However, the enhanced sensitivity of this test can lead to unexpected and significant findings. We sought to identify the frequency and types of nonparathyroid detections by SPECT-CT. Read More

World J Clin Cases 2020 Mar;8(6):1180-1187

Department of Minimally Invasive Surgery, Hernia and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.

Background: Giant paraesophageal hiatal hernias (HH) are very infrequent, and their spectrum of clinical manifestations is large. Giant HH mainly occurs in elderly patients, and its relationship with anemia has been reported. For the surgical treatment of large HH, Nissen fundoplication is the most common antireflux procedure, and the reinforcement of HH repair with a patch (either synthetic or biologic) is still debatable. Read More

Surg Obes Relat Dis 2020 Apr 25;16(4):471-475. Epub 2020 Jan 25.

Department of Surgery, Texas Tech University Health Sciences Center Paul Foster School of Medicine, El Paso, Texas.

Background: Gastric bypasses were the most common bariatric surgery for many years, and long-term complications after gastric bypass are known to be relatively common. Symptomatic hiatal hernia (HH) with pouch migration is a less-known complication. However, when these are symptomatic, they require surgical repair. Read More

J Am Coll Surg 2020 Apr 16;230(4):700-707. Epub 2020 Jan 16.

Department of Surgery, University of Pennsylvania, Philadelphia, PA. Electronic address:

Background: The natural history of hiatal herniation of small and/or large bowel post-esophagectomy (HHBPE) in the current era of improving long-term survival and evolving surgical technique is unknown. The aim of this study was to describe the rate and risk factors of HHBPE at our hospital.

Methods: Patients undergoing esophagectomy between January 2011 and June 2017 were included if both follow-up information and axial imaging were available beyond 3 months post-esophagectomy. Read More

BMJ Case Rep 2019 Dec 5;12(12). Epub 2019 Dec 5.

Surgery, Memorial University Medical Center, Savannah, Georgia, USA.

Mediastinal haematoma is a rare complication of laparoscopic paraoesophageal hernia repair with few documented cases in the current literature. Presentation of this unique clinical problem can range from extrinsic oesophageal obstruction to life-hreatening cardiac tamponade and therefore, warrants further discussion of at-risk population aetiology, diagnosis and successful management strategies. We present the case of a 71-year-old woman who underwent laparoscopic paraoesophageal hernia repair with nissen fundoplication complicated by severe dysphagia on postoperative day 12. Read More

Clin Pract Cases Emerg Med 2019 Nov 14;3(4):432-433. Epub 2019 Aug 14.

Hachinohe City Hospital, Department of Gastroenterology, Endoscope, and Chemotherapy, Hachinohe, Aomori.

Physiological shock requires prompt diagnosis and treatment in the emergency department. We present a case of physiological shock in a 91-year-old woman resulting from obstruction of the left atrium and inferior vena cava by a giant esophageal hiatal hernia, identified using computed tomography imaging. The patient's age and history, including diet and eating behavior (namely needing to lie down immediately after a meal), and kyphotic posture were important factors to consider in establishing the differential diagnosis. Read More

Med Pharm Rep 2019 Oct 25;92(4):321-325. Epub 2019 Oct 25.

2 Medical Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background And Aim: Hiatal hernia (HH) occurs quite frequently in the general population and is characterized by a wide range of non-specific symptoms, most of them related to gastroesophageal reflux disease. Treatment can be challenging at times, depending on the existence of complications. The most recent guideline regarding the management of hiatal hernia was released by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) in the year 2013. Read More

J Neurogastroenterol Motil 2020 Jan;26(1):51-60

Departments of Gastroenterology, University of California San Diego, La Jolla, CA, USA.

Background/aims: The esophageal hiatus is formed by the right crus of the diaphragm in the majority of subjects. Contraction of the hiatus exerts a sphincter-like action on the lower esophageal sphincter (LES). The aim is to study the hiatal anatomy (using CT scan imaging) and function (using high-resolution manometry [HRM]), and esophageal motor function in patients with sliding and paraesophageal hiatal hernia. Read More

Am J Case Rep 2019 Oct 18;20:1530-1535. Epub 2019 Oct 18.

Department of Surgery, Iwate Medical University, Morioka, Iwate, Japan.

BACKGROUND Upside-down stomach (UDS) is the rarest type of hiatal hernia (HH), with organoaxial gastric volvulus. A large HH sometimes causes cardiopulmonary impairments owing to multiple factors. CASE REPORT We herein report a case of a large HH with UDS that had induced weight loss and severe cardiopulmonary dysfunction in a 74-year-old female patient who presented with shortness of breath, chest pain, severe anorexia, and weight loss of 5 kg over the 3 previous months. Read More

Clin Exp Rheumatol 2019 Jul-Aug;37 Suppl 119(4):108-114. Epub 2019 Oct 3.

SOD Radiologia Pediatrica e Specialistica, Dipartimento di Scienze Radiologiche, AOU Ospedali Riuniti di Ancona and Dipartimento di Scienze Cliniche e Specialistiche, Università Politecnica delle Marche, Ancona, Italy.

Objectives: The aim of our study was to assess the role of videofluorography (VFG) in the evaluation of swallowing and oesophageal peristalsis in patients with systemic sclerosis (SSc).

Methods: From June 2014 to September 2017, 55 consecutive SSc patients, defined according to the 2013 ACR/EULAR classification criteria, underwent VFG study using a remote-controlled digital device. In order to evaluate possible abnormalities, 18 dynamic parameters were chosen, dividing the act of swallowing into three phases: oral, pharyngeal and oesophageal phases. Read More

J Neurogastroenterol Motil 2019 10;25(4):499-507

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Colleg e, Beijing, China.

Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary peristalsis, abnormal response to multiple rapid swallowing, and hiatal hernia. Read More

Thorac Surg Clin 2019 Nov;29(4):427-436

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, UPMC Mercy, 1400 Locust Street, Pittsburgh, PA 15219, USA. Electronic address:

Recurrent symptomatic paraesophageal hernias (PEHs) can lead to significant morbidity if untreated. Surgical treatment of recurrent PEH can pose a great challenge. Several different surgical options are available and need to be considered on an individual basis. Read More

Thorac Surg Clin 2019 Nov 26;29(4):359-368. Epub 2019 Sep 26.

Department of Thoracic Medicine and Surgery, Division of Thoracic Surgery, Lewis Katz School of Medicine at Temple University, 3401 North Broad Street C-501, Philadelphia, PA 19140, USA; Department of Surgical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue C-312, Philadelphia, PA 19111, USA.

Paraesophageal hernia represents a complex surgical problem involving significant distortion of the anatomy and function of the esophagus, stomach, gastroesophageal junction, mediastinum, lungs, and heart. Surgeons operating in the area must have deep understanding of the normal anatomy and pathologic derangements in patients with paraesophageal hernias. This article describes the normal anatomy and anatomic abnormalities in application to the various approaches used in the surgical repair of a paraesophageal hernia. Read More

J Laparoendosc Adv Surg Tech A 2019 Nov 20;29(11):1446-1450. Epub 2019 Sep 20.

Department of Upper GI and Bariatric Surgery, Shrewsbury and Telford Hospital NHS Trust, Shrewsbury, United Kingdom.

Symptomatic paraesophageal hernia (PEH) is an indication for surgical repair. Laparoscopic suture repair has high recurrence rates. Many surgeons prefer mesh repair to reduce PEH recurrence. Read More

Vet J 2019 Sep 27;251:105344. Epub 2019 Jul 27.

University of Missouri, College of Veterinary Medicine, Department of Veterinary Medicine and Surgery, 900 East Campus Drive, Columbia, MO 65211, USA. Electronic address:

Aerodigestive diseases, hybrid disorders representing a pathologic link between respiratory and alimentary tracts, may manifest with respiratory signs without gastrointestinal signs. These are underdiagnosed in dogs due to poor clinical recognition and diagnostic limitations. We hypothesize that a subset of dogs presenting for cough without gastrointestinal signs would have occult aerodigestive disorders identified using videofluoroscopic swallow study (VFSS). Read More

Korean J Gastroenterol 2019 Aug;74(2):110-114

Division of Gastroenterology, Department of Internal Medicine, Presbyterian Medical Center, Jeonju, Korea.

The Chicago classification (CC) defines an esophagogastric junction outflow obstruction (EGJOO) as the presence of several instances of intact or weak peristalsis, elevated median integrated relaxation pressure above 15 mmHg, and a discrepancy from the criteria of achalasia. The revised CC addresses the potential etiology of EGJOO, including the early forms of achalasia, mechanical obstruction, esophageal wall stiffness, or manifestation of hiatal hernia. A 58-year-old woman visited the Presbyterian Medical Center with swallowing difficulty. Read More

Eur Heart J Case Rep 2019 Sep;3(3)

Department of Cardiology, University Hospital Basel and University of Basel, Petersgraben 4, CH-4031 Basel, Switzerland.

Background: Acute coronary syndrome (ACS) can be a life-threatening condition. However, identification of patients with ACS can be challenging, especially among women, and clinical presentation can often overlap with other medical entities.

Case Summary: A 61-year-old woman with a history of stable bronchial asthma presented with worsening dyspnoea for spiroergometry. Read More

Surgery 2019 10 13;166(4):540-546. Epub 2019 Aug 13.

Department of Surgery, McGill University Health Centre, Montreal, QC, Canada; Steinberg-Bernstein Centre for Minimally Invasive Surgery and Innovation, McGill University Health Centre, Montreal, QC, Canada. Electronic address:

Background: Fundoplication is performed routinely during laparoscopic repairs of a paraesophageal hernia, but the degree of fundoplication remains controversial. The purpose of this study is to assess postoperative dysphagia and reflux after a Dor versus a Nissen fundoplication in patients undergoing laparoscopic repair of giant paraesophageal hernias.

Methods: We performed a retrospective cohort study of all patients undergoing laparoscopic repair of giant paraesophageal hernias with Nissen or Dor fundoplication between January 2012 and December 2017 at a high-volume center, excluding revisional and emergency cases. Read More

Surg Endosc 2020 Apr 12;34(4):1785-1794. Epub 2019 Aug 12.

Division of Gastrointestinal and Minimally Invasive Surgery, Department of Surgery, Carolinas Medical Center, 1025 Morehead Medical Drive, Suite 300, Charlotte, NC, 28204, USA.

Background: Despite advances in diagnostic imaging capabilities, little information exists concerning the impact of physical dimensions of a paraesophageal hernia (PEH) on intraoperative decision making. The authors hypothesized that computerized volumetric analysis and multidimensional visualization to measure hiatal defect area (HDA) and intrathoracic hernia sac volume (HSV) would correlate to operative findings and required surgical techniques performed.

Methods: Using volumetric analysis software (Aquarius iNtuition, TeraRecon, Inc), HDA and HSV were measured in PEH patients with preoperative computerized tomography (CT) scans, and used to predict the likelihood of intraoperative variables. Read More

Cir Esp 2019 Nov 3;97(9):547-548. Epub 2019 Aug 3.

Servei de Cirurgia General, Hospital Universitari Vall d'Hebron, Barcelona, España.

Anatol J Cardiol 2019 Aug;22(2):5002

Department of Cardiology, İstanbul Faculty of Medicine, İstanbul University; İstanbul-Turkey.

World J Gastroenterol 2019 Jul;25(25):3231-3241

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan.

Background: Barrett's esophagus (BE) is a pre-malignant condition associated with the development of esophageal adenocarcinoma. The prevalence of BE in the general populations of Asian countries ranges from 0.06% to 1%. Read More

Surgery 2019 11 19;166(5):886-894. Epub 2019 Jun 19.

Department of Surgery, University Hospital, University of Chile, Santiago, Chile.

Introduction: Laparoscopic Nissen fundoplication is the preferred operative treatment for patients with gastroesophageal reflux disease. The most recent published results only refer to clinical evaluations and few discuss objective measurements. Our purpose was to determine the late results of laparoscopic Nissen fundoplication, performing clinical, endoscopic, histologic, and functional studies. Read More

Ann Endocrinol (Paris) 2019 Sep 20;80(4):196-201. Epub 2019 May 20.

Uludag University Medical School, Department Of Endocrinology and Metabolism, Bursa, Turkey. Electronic address:

Purpose: Acromegaly causes multiple comorbidities, including gastrointestinal disorders. The present study evaluated the frequency of hiatal hernia and other upper gastrointestinal pathologies in patients with acromegaly, given that visceromegaly and reduced nitric oxide levels in acromegaly may impact diaphragm and lower esophageal sphincter function and thus possibly the development of hiatal hernia.

Methods: Thirty-nine acromegaly patients followed our center for the previous 6months were recruited. Read More

J Vet Intern Med 2019 Jul 19;33(4):1740-1746. Epub 2019 Jun 19.

Hospital for Small Animals, Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Midlothian, UK.

Background: Idiopathic esophageal dysmotility (ED) is increasingly recognized in young dogs of brachycephalic breeds. Few studies have objectively associated specific videofluoroscopic swallowing study (VFSS) features with brachycephaly, leading to under-recognition of ED in brachycephalic breeds.

Hypothesis/objectives: To describe and compare VFSS in brachycephalic dogs versus non-brachycephalic dogs presented for dysphagia or regurgitation, and to investigate associations between these imaging findings and patient signalment. Read More

Surg Endosc 2020 Apr 19;34(4):1761-1768. Epub 2019 Jun 19.

Department of Surgery, Northshore University HealthSystem, 2650 Ridge Ave, GCSI Suite B665, Evanston, IL, 60201, USA.

Introduction: The purpose of this study is to evaluate the utility of using a functional lumen imaging probe (EndoFLIP™) intra-operatively during hiatal hernia repair and fundoplication. Additionally, we hypothesize that these measurements correlate with long-term outcomes.

Methods: A prospectively maintained quality database was queried. Read More

Eur Radiol 2019 Dec 11;29(12):6653-6661. Epub 2019 Jun 11.

Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, 37075, Göttingen, Germany.

Purpose: To assess the diagnostic potential of real-time MRI for assessment of hiatal hernias in patients with GERD-like symptoms compared to endoscopy.

Material And Methods: One hundred eight patients with GERD-like symptoms were included in this observational cohort study between 2015 and 2017. Real-time MRI was performed at 3. Read More

N Z Med J 2019 06 7;132(1496):66-68. Epub 2019 Jun 7.

Consultant General Surgeon, Department of General Surgery, Wellington Regional Hospital, Wellington.

BMJ Case Rep 2019 May 14;12(5). Epub 2019 May 14.

Emergency Department, University Hospital Lewisham, London, UK.

An 84-year-old woman presented to the emergency department with a sudden onset of chest pain, shortness of breath and vomiting. She had a medical history of hiatus hernia, gastro-oesophgeal reflux disease and asthma only, but had several recent courses of oral steroids to treat her asthma. Initially she was hypoxic, tachycardic and normotensive. Read More

Medicine (Baltimore) 2019 May;98(19):e15543

Department of Trauma and Orthopaedics, the Second Hospital of Shandong University, Shandong Province, People's Republic of China.

The current study aimed to investigate the relationship between the severity of gastroesophageal reflux disease (GERD) according to the Los Angeles (LA) classification and esophageal motility using high-resolution manometry (HRM) and 24-hour esophageal pH monitoring.We examined 124 patients with GERD from January 2016 to June 2018. The LA classification of each patient was determined by endoscopy. Read More

BMC Nephrol 2019 04 11;20(1):126. Epub 2019 Apr 11.

Molecular Biology Laboratory, Fundació Puigvert, Instituto de Investigaciones Biomédicas Sant Pau (IIB-Sant Pau), Universitat Autònoma de Barcelona, REDinREN, Instituto de Investigación Carlos III, Cartagena 340-350, 08025, Barcelona, Catalonia, Spain.

Background: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset nephrotic syndrome and microcephaly with brain anomalies. WDR73 pathogenic variants were described as the first genetic cause of GAMOS and, very recently, four novel causative genes, OSGEP, LAGE3, TP53RK, and TPRKB, have been identified.

Case Presentation: We present the clinical and genetic characteristics of two unrelated infants with clinical suspicion of GAMOS who were born from consanguineous parents. Read More

Esophagus 2019 07 29;16(3):309-315. Epub 2019 Mar 29.

Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Esophageal eosinophilia (EE) is a basal condition of eosinophilic esophageal disorders including eosinophilic esophagitis (EoE) and asymptomatic EE. EoE is considered as an allergic disorder, while it is unclear whether other non-allergic conditions are involved in the pathophysiology of EE. The aim of this study is to investigate the non-allergic risk factors for EE. Read More

Surg Laparosc Endosc Percutan Tech 2019 Aug;29(4):221-232

International Centre for Applied Climate Sciences and Centre for Health Sciences Research, School of Agricultural, Computing and Environmental Sciences, University of Southern Queensland, Toowoomba, Qld.

Background: To explore the clinical outcomes, safety and effectiveness of suture cruroplasty versus mesh repair for large hiatal hernias (HHs) by an updated meta-analysis.

Material And Methods: Randomized controlled trials evaluating the effects of these 2 treatment modalities were searched from PubMed and other electronic databases between January 1991 and July 2018. The outcome variables analyzed included operating time, complications, recurrence of HH or wrap migration, reoperation, hospital stay and quality of life. Read More

J Gastrointest Surg 2019 06 26;23(6):1095-1103. Epub 2019 Feb 26.

Department of General Surgery, Cleveland Clinic, Desk A-100, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Background: Post-surgical gastroparesis (psGP) is putatively related to vagal denervation from either therapeutic transection or inadvertent injury. Here, we present a series of patients undergoing endoscopic per-oral pyloromyotomy (POP) as a treatment for medically refractory psGP.

Methods: Patients identified from a prospectively maintained database of patients undergoing POP procedures at our institution from January 2016 to January 2018 were included. Read More

Obes Surg 2019 06;29(6):1704-1708

Department of Radiology, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel.

Background: Controversy exists regarding the clinical utility of routine preoperative upper gastrointestinal (GI) fluoroscopy in morbid obese patients undergoing laparoscopic sleeve gastrectomy (LSG). The aim of our study was to determine the efficacy of these studies in detecting hiatal hernias (HH).

Methods: The institution's prospectively maintained, IRB-approved database was retrospectively queried to identify all consecutive patients who underwent LSG between 2011 and 2017. Read More

Surg Laparosc Endosc Percutan Tech 2019 Jun;29(3):203-206

Department of Surgery, University of Calgary, Calgary, AB, Canada.

Introduction: There is conflicting evidence with regard to the routine use of upper gastrointestinal contrast series in detecting early complications post paraesophageal hernia repair (PEHR).

Methods: All cases booked for a PEHR between January 2007 and September 2015 were identified using hospital records. Standard demographic, operation, and imaging data were extracted. Read More

Cir Esp 2019 Aug - Sep;97(7):416-418. Epub 2019 Jan 22.

Centro de Excelencia para el Diagnóstico y el Tratamiento de la Obesidad, Valladolid, España.

Am J Gastroenterol 2019 May;114(5):706

Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

J Gastrointest Surg 2019 04 7;23(4):696-701. Epub 2019 Jan 7.

Center for Advanced Surgical Technology, University of Nebraska Medical Center, 986246 Nebraska Medical Center, Omaha, NE, 68198-6246, USA.

Background: The aim of this study is to identify factors that can predict hiatal hernia recurrence (HHR) in patients after anti-reflux surgery with hiatal hernia (HH) repair.

Methods: A single-institution, prospectively collected database was reviewed (January 2002-October 2015) with inclusion criteria of GERD and laparoscopic anti-reflux (AR) surgery with HH repair. Demographics, esophageal symptom scores, and pre- and post-upper gastrointestinal imaging (UGI) were collected. Read More

Dig Dis Sci 2019 02;64(2):349-352

Division of Gastroenterology and Hepatology, Department of Medicine, University of New Mexico School of Medicine, 1 University of New Mexico, MSC10-5550, Albuquerque, NM, 87131, USA.

Orphanet J Rare Dis 2018 12 17;13(1):226. Epub 2018 Dec 17.

Department of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Chung-Shan North Road, Taipei, Taiwan.

Background: Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disease characterized by the combination of glomerulopathy with early-onset nephrotic syndrome and microcephaly with central nervous system anomalies. Given its clinical heterogeneity, GAMOS is believed to be a genetically heterogenous group of disorders. Recently, it has been reported that mutations in KEOPS-encoding genes, including the OSGEP gene, were responsible for GAMOS. Read More

Surg Laparosc Endosc Percutan Tech 2019 Jun;29(3):182-186

Division of General Surgery.

Introduction: Paraesophageal hernia repairs are prone to recurrence and mesh reinforcement is common. Both biologic and prosthetic meshes have been used. We report a comparison of a new type of biologically derived graft, Gentrix Surgical Urinary Bladder Matrix (UBM). Read More

Digestion 2019 27;99(2):185-190. Epub 2018 Nov 27.

Division of Gastroenterological Surgery, Tokai University, Oiso, Japan.

Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States.

Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6. Read More

Surg Endosc 2019 09 26;33(9):2895-2900. Epub 2018 Nov 26.

Division of General Surgery, University of Kentucky, Lexington, KY, USA.

Background: Laparoscopic hiatal hernia repair via Toupet or Nissen fundoplication remains the most commonly performed procedures for management of large hiatal hernia. Few studies have compared the procedures' long-term effectiveness. This study sought to characterize the efficacy of laparoscopic Toupet versus Nissen fundoplication for types III and IV hiatal hernia. Read More

PLoS Med 2018 11 20;15(11):e1002686. Epub 2018 Nov 20.

Department of Radiology, Stanford University, Stanford, California, United States of America.

Background: Chest radiograph interpretation is critical for the detection of thoracic diseases, including tuberculosis and lung cancer, which affect millions of people worldwide each year. This time-consuming task typically requires expert radiologists to read the images, leading to fatigue-based diagnostic error and lack of diagnostic expertise in areas of the world where radiologists are not available. Recently, deep learning approaches have been able to achieve expert-level performance in medical image interpretation tasks, powered by large network architectures and fueled by the emergence of large labeled datasets. Read More

Ann Neurol 2018 12;84(6):814-828

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama.

Objective: Galloway-Mowat syndrome (GAMOS) is a neural and renal disorder, characterized by microcephaly, brain anomalies, and early onset nephrotic syndrome. Biallelic mutations in WDR73 and the 4 subunit genes of the KEOPS complex are reported to cause GAMOS. Furthermore, an identical homozygous NUP107 (nucleoporin 107kDa) mutation was identified in 4 GAMOS-like families, although biallelic NUP107 mutations were originally identified in steroid-resistant nephrotic syndrome. Read More

Eur Radiol 2019 Aug 12;29(8):4400-4407. Epub 2018 Nov 12.

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: To evaluate the diagnostic performance of swallowing MRI of the gastroesophageal junction (GEJ) in the postoperative care of patients after laparoscopic antireflux surgery (LARS) MATERIAL AND METHODS: In this institutional review board-approved prospective study, 79 symptomatic patients (mean age, 52.3 years; range, 26-80 years) were evaluated after laparoscopic Nissen fundoplication. MRI findings were correlated with revision surgery, endoscopy, and high-resolution manometry (HRM) as standard of reference. Read More