Search Our Scientific Publications & Authors

J Rehabil Med 2020 05 31;52(5):jrm00066. Epub 2020 May 31.

U1179 INSERM, Université Versailles Saint Quentin en Yvelines, UFR des Sciences de la Santé - Simone Veil, 78170 Montigny le Bretonneux, France. E-mail.

Objective: To evaluate recurrence and early postoperative complications (sepsis) following surgical excision combined with radiotherapy for troublesome hip heterotopic ossification in patients with spinal cord injury and traumatic brain injury.

Design: Retrospective case-control study.

Setting: Data relating to patients with spinal cord injury or traumatic brain injury who underwent surgical excision of hip heterotopic ossification were retrieved from the BANKHO database. Read More

Spinal Cord Ser Cases 2020 May 13;6(1):41. Epub 2020 May 13.

Surgical Services, VA Palo Alto Health Care System, Palo Alto, CA, USA.

Introduction: Patients with complete spinal cord injury (SCI) may develop concurrent sequalae that interact and share symptoms; thus, a careful approach to diagnosis and management of new symptoms is crucial.

Case Presentation: A patient with prior T4 complete SCI presented with progressive autonomic nervous system (ANS) dysfunction. The initial differential diagnosis included syringomyelia and lumbar Charcot arthropathy. Read More

J Spinal Cord Med 2020 May 12:1-5. Epub 2020 May 12.

Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

Heterotopic ossification is characterized by abnormal growth of bone in soft tissues. Neurogenic heterotopic ossification is also closely related to central nervous system injuries and has been reported to respond to radial extracorporeal shock wave therapy. In this case, a radial extracorporeal shock wave therapy (five times per week, lasted for almost one year) was applied to a patient with neurogenic heterotopic ossification on the left hip as a result of spinal cord injury. Read More

Clin Neurol Neurosurg 2020 May 1;195:105821. Epub 2020 May 1.

Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Heterotopic Ossification (HO) refers to the formation of bone within soft tissue. Traumatic spinal cord injury (SCI) has been shown to be associated with development of HO. However, risk factors for HO following SCI are unknown. Read More

J Cell Mol Med 2020 May 15;24(10):5428-5437. Epub 2020 Apr 15.

Department of Orthopaedic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Much of the similarities of the tissue characteristics, pathologies and mechanisms of heterotopic ossification (HO) formation are shared between HO of tendon and ligament (HOTL). Unmet need and no effective treatment has been developed for HOTL, primarily attributable to poor understanding of cellular and molecular mechanisms. HOTL forms via endochondral ossification, a common process of most kinds of HO. Read More

Clin Neurol Neurosurg 2020 Jun 17;193:105737. Epub 2020 Feb 17.

Mayo Clinic Neuro-Informatics Laboratory, Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA; Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Heterotopic ossification(HO) is a common complication following spinal cord injury(SCI); however, its underlying pathophysiology remains relatively unknown. Although there are options for treating HO, prophylactic treatment is limited. Additionally, evidence supporting the effectiveness of these prophylactic treatments is scarce. Read More

J Wound Care 2020 Mar;29(Sup3):S30-S32

1 Department of Plastic Surgery, University of Tennessee Health Science Center, Memphis, US.

Objective: Heterotopic ossification is the formation of ectopic bone in soft tissues. It has three established aetiologies: genetic, traumatic and neurogenic. A gossypiboma is defined as a retained foreign body, such as a mass or sponge, usually after a surgical procedure. Read More

World Neurosurg 2020 Mar;135:377-378

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Spinal Program, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada.

J Musculoskelet Neuronal Interact 2020 Mar;20(1):160-164

Demiroglu Bilim University Medical Faculty, Physical Medicine and Rehabilitation Department, Istanbul, Turkey.

Neurogenic heterotopic ossification (NHO) is an abnormal development of bone in extra-skeletal tissues, related to neurological disease. NHO is frequently seen after traumatic brain injury or spinal cord injury. NHO may also occur as a rare complication of Guillain Barre Syndrome (GBS). Read More

Sci Rep 2020 Jan 28;10(1):1305. Epub 2020 Jan 28.

Department of Orthopedics, Tangdu Hospital affiliated with Air Force Medical University, Xi'an, Shanxi Province, P.R. China.

Minimally invasive surgery (MIS) has shown satisfactory surgical results for the treatment of thoracic myelopathy (TM) caused by ossification of the ligamentum flavum (OLF). This study investigated the prognostic factors following MIS and was based on the retrospective analysis of OLF patients who underwent percutaneous full endoscopic posterior decompression (PEPD). Thirty single-segment OLF patients with an average age of 60. Read More

PeerJ 2020 3;8:e8276. Epub 2020 Jan 3.

Department of Trauma and Orthopaedic Surgery, Peking University People's Hospital, Beijing, China.

Background: Neurogenic heterotopic ossification is a disorder of aberrant bone formation affecting one in five patients sustaining a spinal cord injury or traumatic brain injury (SCI-TBI-HO). However, the underlying mechanisms of SCI-TBI-HO have proven difficult to elucidate. The aim of the present study is to identify the most promising candidate genes and biological pathways for SCI-TBI-HO. Read More

Zhongguo Gu Shang 2019 Dec;32(12):1102-1107

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China;

Objective: To compare the application of multi-mode and single-mode intraoperative neurophysiological monitoring in the treatment of severe ossification of posterior longitudinal ligament of cervical spine with anterior cervical corpectomy with fusion.

Methods: From April 2015 to June 2018, 32 patients with severe ossification of the posterior longitudinal ligament were treated in the Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. There were 21 males and 11 females, aged 45 to 73 years old, with a mean age of 59 years old. Read More

Br J Hosp Med (Lond) 2019 Dec;80(12):707-710

Consultant Radiologist, Department of Radiology, National Rehabilitation Hospital, Dublin, Ireland.

Neurogenic heterotopic ossification is a condition whereby bone forms in an extra-skeletal site. It may occur in the context of major neurological insult involving the brain or spinal cord. It causes pain and restricts movement, most commonly at the hip joints. Read More

BMC Musculoskelet Disord 2019 Dec 7;20(1):589. Epub 2019 Dec 7.

Department of Orthopaedic Surgery, Toho University Sakura Medical Center, Center 564-1, Shimoshizu, Sakura, Chiba, 285-8741, Japan.

Background: Recent reports indicate that oxidative stress induced by reactive oxygen species is associated with the pathobiology of neurodegenerative disorders that involve neuronal cell apoptosis. Here we conducted a cross-sectional study to evaluate serum levels of oxidative stress in cervical compression myelopathy.

Methods: Thirty-six serum samples were collected preoperatively from patients treated for acutely worsening compression myelopathy (AM) and chronic compression myelopathy (CM). Read More

Arthrosc Tech 2019 Sep 18;8(9):e1057-e1062. Epub 2019 Sep 18.

Mississippi Sports Medicine and Orthopaedic Center, Jackson, Mississippi, U.S.A.

The formation of heterotopic ossification around the shoulder is a rare but potentially debilitating condition. It is found most commonly around the hip and is usually associated with an inciting event such as trauma, burn, previous surgery, or traumatic brain/spinal cord injury. The formation of shoulder heterotopic ossification following arthroscopic surgery is very uncommon, with few data pertaining to it in the current literature. Read More

World Neurosurg 2020 Feb 9;134:e739-e746. Epub 2019 Nov 9.

Orthopaedic Department, Peking University Third Hospital, Beijing, China.

Background: Although research shows that the ossified masses of ossification of the posterior longitudinal ligament (OPLL) continue to grow postoperatively, information regarding thoracic OPLL (T-OPLL) is lacking. To date, no study has investigated the progression of T-OPLL within each motion segment. The purpose of this study was to analyze the progression of T-OPLL in each motion segment using a 3-dimensional measurement and evaluate whether the type of T-OPLL and surgical methods affect its progression postoperatively. Read More

World Neurosurg 2020 Jan 21;133:314-317. Epub 2019 Oct 21.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah, USA.

Background: The adult spinal cord is typically resistant to hypoxic-ischemic injury because of collateral blood supply; however, congenital or acquired stenosis may result in baseline maximal vasodilation, such as superimposed hemodynamic stresses, that cannot be accommodated, leaving the spinal cord vulnerable to ischemic injury. We present a rare case of spinal cord hypoxic-ischemic injury in an adult with underlying cervical spinal stenosis.

Case Description: A 37-year-old man with a history of morbid obesity, diabetes mellitus, hypertension, and obstructive sleep apnea presented after developing progressive weakness in the extremities. Read More

Spinal Cord Ser Cases 2019 21;5:72. Epub 2019 Aug 21.

2Department of Biostatistics, St. John's Medical College Hospital, Bengaluru, Karnataka India.

Study Design: This was a single-centre, retrospective, descriptive, hospital-based study in persons with spinal cord injuries (SCI) patients.

Objectives: To study the incidence and characteristics of heterotopic ossification (HO) after SCI.

Setting: The in-patient services of the Department of Physical Medicine and Rehabilitation of a tertiary care institute in India between January 2001 and December 2017. Read More

Medicine (Baltimore) 2019 Oct;98(42):e17505

Department of Orthopedic Surgery, the Orthopedics Hospital of XingTai, XingTai.

The purpose of the study was to identify risk factors of cage subsidence and evaluate surgical outcome by at least 12 months postoperative follow-up.We retrospectively investigated 113 consecutive patients who underwent anterior surgery to relieve spine cord compression resulted from localized heterotopic ossification, from July, 2011 to February, 2016. We divided the patients into 2 groups: cage subsidence <2 mm group and ≥2 mm group. Read More

World Neurosurg 2019 Dec 23;132:197-201. Epub 2019 Aug 23.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

Background: Gunshot wounds are the most common etiology of penetrating spine injuries and have been increasing in incidence in civilian populations. Although these injuries typically result in severe neurologic deficits, operative intervention remains is controversial and is usually reserved for patients with neurologic deterioration, a persistent externalized cerebrospinal fluid fistula, mechanical instability, metallic toxicity, or a bullet location at high risk of migration.

Case Description: A previously asymptomatic patient who had sustained a gunshot wound to the cervical spine 20 years previously presented with new-onset progressive myelopathy and radiculopathy secondary to heterotopic ossification (HO) surrounding the retained bullet fragments near the left lateral masses of C5-T1. Read More

World Neurosurg 2019 Sep 26;129:359-362. Epub 2019 Jun 26.

Department of Radiology, Fortis Memorial Research Institute, SRL Diagnostics Ltd, Gurugram, Haryana, India. Electronic address:

Background: Intraspinal degenerative cysts in the cervical region are rare disorders that may cause myelopathy or radiculopathy. Most of the intraspinal degenerative cysts reported are extradural cysts. This case report includes the neuroimaging, intraoperative, pathologic, and postoperative findings obtained in a patient with a degenerative intradural cyst at the craniovertebral (CV) junction. Read More

J Spinal Cord Med 2019 Jun 26:1-4. Epub 2019 Jun 26.

a Department of Physical Medicine and Rehabilitation , Veterans Health Service Medical Center , Seoul , Korea.

To evaluate the efficacy and safety of treatment for neurogenic heterotopic ossification (NHO) using extracorporeal shock wave therapy (ESWT) in persons with spinal cord injury (SCI). Single case report. Department of Physical Medicine and Rehabilitation, Veterans Health Service Medical Center. Read More

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):2569-2574

a Department of Emergency Surgery, Qilu Hospital of Shandong University , Jinan , P. R. China.

Interactions between the heterotopic ossification (HO) and the neurological injuries have got lots of interest but still poorly understood. The present study aims to determine the effect of neuroinflammation related calcitonin gene-related protein (CGRP) on HO following spinal cord injury (SCI). C57Bl6 mice were anesthetized to make an SCI model, together with the ectopic injection of snake venom cardiotoxin (SVC) or CGRP protein into tibialis anterior (TA) muscles. Read More

EFORT Open Rev 2019 Jun 3;4(6):263-268. Epub 2019 Jun 3.

Service de Chirurgie Orthopédique, Hôpital Raymond Poincaré, France.

Traumatic neurological lesions may lead to development of heterotopic ossification. These cases are classified as 'neurogenic heterotopic ossifications' (NHOs). The associated neurological lesions can be caused by cranial trauma or spinal cord injury and may sometimes include a local trauma. Read More

Orthopade 2019 Oct;48(10):844-848

Neurochirurgische Praxis, Zeppelinstr. 24, 61352, Bad Homburg, Deutschland.

Background And Objective: Thoracic spinal stenosis is characterized by a reduction in the volume of the thoracic spinal canal, leading to compromise of the spinal cord or nerve roots. This article provides an overview of the known etiology, pathogenesis, diagnostic algorithm, and treatment of thoracic spinal stenosis.

Materials And Methods: This paper is based on an overview of the literature from the past 25 years as well as the authors' own experience and results. Read More

Cureus 2019 Feb 5;11(2):e4019. Epub 2019 Feb 5.

Physical Medicine and Rehabilitation, King Fahad Medical City, Riyadh, SAU.

A 33-year-old male victim of a motor vehicle accident, who presented with a T12 (thoracic 12 vertebra) burst fracture (ISNCSCI T11 AIS-A: International Standards for Neurological Classification of Spinal Cord Injury T11 ASIA Impairment Scale), was admitted to a rehabilitation hospital. A stage-II left ischial pressure ulcer was also reported. An X-ray of the pelvis revealed bilateral neurogenic heterotopic ossification (NHO) in both hips and knees, which was further confirmed by TC-99m methylene diphosphonate (MDP) bone scintigraphy. Read More

Orthopedics 2019 May 9;42(3):e309-e316. Epub 2019 Apr 9.

The purpose of this study was to compare the clinical effect of anterior cervical corpectomy with fusion vs laminoplasty for cervical ossification of the posterior longitudinal ligament. The outcome measures included the Japanese Orthopaedic Association score, neurological recovery rate, and complication rate. Subgroup A represented studies with the mean preoperative canal occupying ratio being less than 50%, whereas subgroup B represented studies with the mean canal occupying ratio being 50% or greater. Read More

World Neurosurg 2019 Jun 28;126:593-600. Epub 2019 Mar 28.

Department of Orthopaedic Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China. Electronic address:

Objective: The purpose of this study was to provide a systematic and comprehensive review of the existing literature regrading postoperative ossification of posterior longitudinal ligament (OPLL) progression.

Methods: Using the PRISMA guidelines, we conducted an exhaustive review of electronic databases. Potential articles were screened and related information was extracted and analyzed. Read More

Front Immunol 2019 7;10:377. Epub 2019 Mar 7.

Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.

Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of traumatic brain and spinal cord injuries (SCI) which manifest as abnormal formation of bone tissue in periarticular muscles. NHO are debilitating as they cause pain, partial or total joint ankylosis and vascular and nerve compression. NHO pathogenesis is unknown and the only effective treatment remains surgical resection, however once resected, NHO can re-occur. Read More

Spine (Phila Pa 1976) 2019 Aug;44(16):E957-E964

Department of Rehabilitation Medicine, Bundang Jesaeng General Hospital, Gyeonggi-do, Republic of Korea.

Study Design: Case-control study.

Objective: To quantify risk factors for cervical ossification of the posterior longitudinal ligament (OPLL) using a large nationwide cohort in Korea, a country with a high prevalence of OPLL.

Summary Of Background Data: OPLL is a pathological calcification of the posterior longitudinal ligament of the spine. Read More

Zhonghua Wai Ke Za Zhi 2019 Mar;57(3):176-181

Department of Spine Surgery, Changzheng Hospital, Naval Military Medical University, Shanghai 200003, China.

To investigate the clinical application value of using laminoplasty combine with short-segment pedicle screw fixation in the treatment of cervical spine trauma patients with ossification of posterior longitudinal ligament (OPLL). Fifty-four cervical spine trauma patients with OPLL from June 2014 to June 2016 were retrospectively analyzed of Department of Spine Surgery, Changzheng Hospital, Naval Military Medical University. There were 31 males and 23 females, aging (68. Read More

Ann Phys Rehabil Med 2019 May 1;62(3):189-192. Epub 2019 Feb 1.

Stem Cell Biology Laboratory, Cancer Care and Biology Program, Mater Research, University of Queensland, Woolloongabba, Queensland, Australia; School of Medicine, University of Queensland, Herston, Queensland, Australia. Electronic address:

Medicine (Baltimore) 2019 Jan;98(1):e13382

Department of Orthopaedic, Affiliated Hospital of Hebei University.

Background: Both anterior decompression and fusion (ADF) and laminoplasty (LAMP) are frequently used for the treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL). However, some controversies still remained in surgical options. We investigated whether ADF had better neurological outcome than LAMP in the treatment of cervical myelopathy due to OPLL. Read More

J Wound Care 2018 11;27(11):774-778

Department of Spinal Cord Injury, BG-University Hospital Bergmannsheil, Ruhr-University, Bochum, Bochum, Germany.

Objective: To analyse the clinical outcome of subtrochanteric femur resection in patients with infected hip joints caused by pressure ulcers (PUs) in patients following spinal cord injury (SCI).

Method: A retrospective cohort study, carried out between January 2004 and December 2015. Only patients receiving a subtrochanteric femur resection were included. Read More

Spine J 2019 04 20;19(4):735-743. Epub 2018 Oct 20.

Spine Center, Department of Orthopedics, Changzheng Hospital, Second Military Medical University, 415th Feng Yang Road, Shanghai 200003, PR China. Electronic address:

Background Context: The presence of ossification of posterior longitudinal ligament (OPLL) can lead to symptomatic spinal cord compression and myelopathy. The surgical approach in patients with myelopathy is influenced by the presence of OPLL. Diagnose of OPLL currently requires computed tomography which incurs a large dose of radiation. Read More

J Spinal Cord Med 2019 07 18;42(4):517-525. Epub 2018 Oct 18.

b Department of Orthopaedic Surgery, Faculty of Medicine , University of Tsukuba , Tsukuba , Japan.

The hybrid assistive limb (HAL) is a wearable exoskeleton robot that assists walking and lower limb movements via real-time actuator control. Our aim was to clarify the safety and feasibility of using the HAL robotic suit for rehabilitation in patients with severe thoracic myelopathy due to ossification of the posterior longitudinal ligament (T-OPLL). Uncontrolled case series; pre- and post-intervention measurement. Read More

Spinal Cord 2019 Mar 25;57(3):214-220. Epub 2018 Sep 25.

Santa Clara Valley Medical Center, San Jose, CA, USA.

Study Design: Retrospective chart review.

Objectives: The objective of this study is to evaluate the efficacy of nonsteroidal anti-inflammatory drug (NSAID) prophylaxis for heterotopic ossification (HO) in the acute phase after spinal cord injury (SCI).

Setting: Acute rehabilitation hospital in California, USA. Read More

J Neurosurg Spine 2018 Dec;29(6):622-627

1Department of Neurosurgery and Spine Surgery, Iseikai Hospital, Osaka; and.

OBJECTIVEThis study aimed to investigate the characteristics of cervical degeneration in Japanese professional wrestlers and its relationship with the risk of cervical spine injury (CSI).METHODSSince 2012, 27 Japanese male wrestlers belonging to a professional wrestling association have undergone periodical medical examinations of the cervical spine. If neurological symptoms were observed in the wrestlers, the resident trainers urged them to undergo a brief examination at the authors' institutions. Read More

J Clin Neurosci 2018 Oct 29;56:21-27. Epub 2018 Aug 29.

Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address:

Posterior surgery has been widely used as an initial surgery for cervical ossification of the posterior longitudinal ligament (OPLL). However, some patients require revision surgery because of failure of symptom relief or late neurological deterioration after posterior surgery. The aim of this study is to retrospectively investigated the surgical results and complications of anterior controllable antedisplacement fusion (ACAF) as a revision surgical technique after initial posterior surgery for OPLL. Read More

Clin Exp Pharmacol Physiol 2018 12 4;45(12):1229-1235. Epub 2018 Oct 4.

Department of Orthopaedics and Traumatology, 1st Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.

Heterotopic ossification (HO) is an abnormal formation of mature lamellar bone within extraskeletal soft tissues, such as muscles, tendons, and ligaments. This process is thought to be induced by inflammation associated with tissue injuries. HO is classified using two subtypes: resulting from injury or genetically inherited. Read More

Medicine (Baltimore) 2018 Aug;97(34):e11605

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, China.

Rationale: We report a rare, acute neurological deterioration after cervical laminoplasty due to post-decompression spinal cord edema associated with ankylosing spondylitis in a 52-year old male patient. The patient was diagnosed with cervical spondylotic myelopathy due to ossification of the posterior longitudinal ligament which was complicated by ankylosing spondylitis. A cervical laminoplasty was performed, adversely resulting in paraparesis and loss of tactile sense. Read More

Int Orthop 2019 04 16;43(4):797-805. Epub 2018 Aug 16.

Rothman Institute, 125 S. 9th St. 10th Floor, Philadelphia, PA, 19107, USA.

Ossification of the posterior longitudinal ligament (OPLL) is a rare pathologic process of lamellar bone deposition that can result in spinal cord compression. While multiple genetic and environmental factors have been related to the development of OPLL, the pathophysiology remains poorly understood. Asymptomatic patients may be managed conservatively and patients with radiculopathy or myelopathy should be considered for surgical decompression. Read More

Yeungnam Univ J Med 2018 06 30;35(1):130-134. Epub 2018 Jun 30.

Department of Radiology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Heterotopic ossification (HO) around the hip joint is not uncommon following neurological injury. Often, surgical treatment is performed in patients with restricted motion and/or refractory pain due to grade III or IV HO according to Brooker classification. The major complication that occurs as a result of surgical HO removal is perioperative bleeding due to hyper-vascularization of the lesion. Read More

Hip Pelvis 2018 Jun 4;30(2):86-91. Epub 2018 Jun 4.

Department of Orthopaedic Surgery, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Purpose: Neurogenic myositis ossificans (NMO) in patients with traumatic spinal cord or brain injuries can cause severe joint ankylosis or compromise neurovascularture. The purpose of this study was to evaluate the clinical and radiological outcomes of and review considerations relevant to surgical resection of NMO of the hip joint.

Materials And Methods: Six patients (9 hips) underwent periarticular NMO resection between 2015 and 2017. Read More

Acta Radiol 2019 Feb 22;60(2):196-203. Epub 2018 May 22.

3 Department of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, PR China.

Background: Ossification of the nuchal ligament (ONL) caused by chronic injury to the nuchal ligament (NL) is very common in instability-related cervical disorders.

Purpose: To determine possible correlations between ONL, sagittal alignment, and segmental stability of the cervical spine.

Material And Methods: Seventy-three patients with cervical spondylotic myelopathy (CSM) and ONL (ONL group) and 118 patients with CSM only (control group) were recruited. Read More

J Neurosurg Spine 2018 08 4;29(2):150-156. Epub 2018 May 4.

OBJECTIVE The range of decompression in posterior decompression and fixation for ossification of the posterior longitudinal ligament in the thoracic spine (T-OPLL) can be established using an index of spinal cord decompression based on the ossification-kyphosis angle (OKA) measured in the sagittal view on MRI. However, an appropriate OKA cannot be achieved in some cases, and posterior fixation is applied in cases with insufficient decompression. Moreover, it is unclear whether spinal cord decompression of the ventral side is essential for the treatment of OPLL. Read More

J Neurosurg Spine 2018 07 27;29(1):97-107. Epub 2018 Apr 27.

2Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences.

OBJECTIVE Granulocyte-colony stimulating factor (G-CSF) is a major growth factor for activation and differentiation of granulocyte colonies in the bone marrow. This cytokine has been widely and safely employed in different conditions over many years. The purpose of this study was to investigate the efficacy of G-CSF administration for traumatic spinal cord injury (TSCI). Read More

J Orthop Translat 2018 Jan 14;12:16-25. Epub 2017 Nov 14.

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Read More

Spine (Phila Pa 1976) 2018 Nov;43(22):1572-1578

Division of Spinal Cord Injury, BG-University Hospital Bergmannsheil, Bochum, Germany.

Study Design: A case-control study; clinical prediction rule.

Objective: The aim of this study was to construct and internally validate a clinical prediction rule to identify patients at high risk of developing heterotopic ossification (HO) after spinal cord injury (SCI).

Summary Of Background Data: HO after SCI can lead to loss of joint mobility, loss of function, peripheral nerve entrapment, and pressure sores. Read More