729 results match your criteria Heterotopic Ossification in Spinal Cord Injury


Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice.

Ann Phys Rehabil Med 2019 Feb 1. Epub 2019 Feb 1.

Stem Cell Biology Laboratory, Cancer Care and Biology Program, Mater Research, University of Queensland, Woolloongabba, Queensland, Australia; School of Medicine, University of Queensland, Herston, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.rehab.2019.01.005DOI Listing
February 2019
1 Read

Anterior decompression and fusion versus laminoplasty for cervical myelopathy due to ossification of posterior longitudinal ligament: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(1):e13382

Department of Orthopaedic, Affiliated Hospital of Hebei University.

Background: Both anterior decompression and fusion (ADF) and laminoplasty (LAMP) are frequently used for the treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL). However, some controversies still remained in surgical options. We investigated whether ADF had better neurological outcome than LAMP in the treatment of cervical myelopathy due to OPLL. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0000
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http://dx.doi.org/10.1097/MD.0000000000013382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344170PMC
January 2019
7 Reads

Outcome of subtrochanteric femur resection in patients with spinal cord injuries.

J Wound Care 2018 11;27(11):774-778

Department of Spinal Cord Injury, BG-University Hospital Bergmannsheil, Ruhr-University, Bochum, Bochum, Germany.

Objective: To analyse the clinical outcome of subtrochanteric femur resection in patients with infected hip joints caused by pressure ulcers (PUs) in patients following spinal cord injury (SCI).

Method: A retrospective cohort study, carried out between January 2004 and December 2015. Only patients receiving a subtrochanteric femur resection were included. Read More

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http://www.magonlinelibrary.com/doi/10.12968/jowc.2018.27.11
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http://dx.doi.org/10.12968/jowc.2018.27.11.774DOI Listing
November 2018
14 Reads

Use of nonsteroidal anti-inflammatory drugs to prevent heterotopic ossification after spinal cord injury: a retrospective chart review.

Spinal Cord 2018 Sep 25. Epub 2018 Sep 25.

Santa Clara Valley Medical Center, San Jose, CA, USA.

Study Design: Retrospective chart review.

Objectives: The objective of this study is to evaluate the efficacy of nonsteroidal anti-inflammatory drug (NSAID) prophylaxis for heterotopic ossification (HO) in the acute phase after spinal cord injury (SCI).

Setting: Acute rehabilitation hospital in California, USA. Read More

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http://dx.doi.org/10.1038/s41393-018-0199-3DOI Listing
September 2018
6 Reads

Heterotopic ossification and spinal cord injury.

Spine (Phila Pa 1976) 2018 Sep 17. Epub 2018 Sep 17.

Department of Nuclear medicine, University Hospital of Ioannina, Greece.

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http://dx.doi.org/10.1097/BRS.0000000000002878DOI Listing
September 2018
4 Reads

Surgical results and complications of anterior controllable antedisplacement fusion as a revision surgery after initial posterior surgery for cervical myelopathy due to ossification of the posterior longitudinal ligament.

J Clin Neurosci 2018 Oct 29;56:21-27. Epub 2018 Aug 29.

Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address:

Posterior surgery has been widely used as an initial surgery for cervical ossification of the posterior longitudinal ligament (OPLL). However, some patients require revision surgery because of failure of symptom relief or late neurological deterioration after posterior surgery. The aim of this study is to retrospectively investigated the surgical results and complications of anterior controllable antedisplacement fusion (ACAF) as a revision surgical technique after initial posterior surgery for OPLL. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.08.014DOI Listing
October 2018
1 Read

Challenges of heterotopic ossification-Molecular background and current treatment strategies.

Clin Exp Pharmacol Physiol 2018 Dec 4;45(12):1229-1235. Epub 2018 Oct 4.

Department of Orthopaedics and Traumatology, 1st Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.

Heterotopic ossification (HO) is an abnormal formation of mature lamellar bone within extraskeletal soft tissues, such as muscles, tendons, and ligaments. This process is thought to be induced by inflammation associated with tissue injuries. HO is classified using two subtypes: resulting from injury or genetically inherited. Read More

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http://doi.wiley.com/10.1111/1440-1681.13025
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http://dx.doi.org/10.1111/1440-1681.13025DOI Listing
December 2018
25 Reads

A rare, acute neurologic deterioration associated with the overactive autoimmune response of ankylosing spondylitis after cervical laminoplasty: A case report.

Medicine (Baltimore) 2018 Aug;97(34):e11605

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, China.

Rationale: We report a rare, acute neurological deterioration after cervical laminoplasty due to post-decompression spinal cord edema associated with ankylosing spondylitis in a 52-year old male patient. The patient was diagnosed with cervical spondylotic myelopathy due to ossification of the posterior longitudinal ligament which was complicated by ankylosing spondylitis. A cervical laminoplasty was performed, adversely resulting in paraparesis and loss of tactile sense. Read More

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http://dx.doi.org/10.1097/MD.0000000000011605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112925PMC
August 2018
4 Reads

Ankylosing Neurogenic Myositis Ossificans of the Hip: A Case Series and Review of Literature.

Hip Pelvis 2018 Jun 4;30(2):86-91. Epub 2018 Jun 4.

Department of Orthopaedic Surgery, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Purpose: Neurogenic myositis ossificans (NMO) in patients with traumatic spinal cord or brain injuries can cause severe joint ankylosis or compromise neurovascularture. The purpose of this study was to evaluate the clinical and radiological outcomes of and review considerations relevant to surgical resection of NMO of the hip joint.

Materials And Methods: Six patients (9 hips) underwent periarticular NMO resection between 2015 and 2017. Read More

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http://dx.doi.org/10.5371/hp.2018.30.2.86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990535PMC
June 2018
16 Reads

Granulocyte-colony stimulating factor administration for neurological improvement in patients with postrehabilitation chronic incomplete traumatic spinal cord injuries: a double-blind randomized controlled clinical trial.

J Neurosurg Spine 2018 Jul 27;29(1):97-107. Epub 2018 Apr 27.

2Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences.

OBJECTIVE Granulocyte-colony stimulating factor (G-CSF) is a major growth factor for activation and differentiation of granulocyte colonies in the bone marrow. This cytokine has been widely and safely employed in different conditions over many years. The purpose of this study was to investigate the efficacy of G-CSF administration for traumatic spinal cord injury (TSCI). Read More

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http://dx.doi.org/10.3171/2017.11.SPINE17769DOI Listing
July 2018
11 Reads

Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification.

J Orthop Translat 2018 Jan 14;12:16-25. Epub 2017 Nov 14.

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, 518055, China.

Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Read More

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http://dx.doi.org/10.1016/j.jot.2017.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866497PMC
January 2018
5 Reads

Clinical Prediction Rule for Heterotopic Ossification of the Hip in Patients with Spinal Cord Injury.

Spine (Phila Pa 1976) 2018 Nov;43(22):1572-1578

Division of Spinal Cord Injury, BG-University Hospital Bergmannsheil, Bochum, Germany.

Study Design: A case-control study; clinical prediction rule.

Objective: The aim of this study was to construct and internally validate a clinical prediction rule to identify patients at high risk of developing heterotopic ossification (HO) after spinal cord injury (SCI).

Summary Of Background Data: HO after SCI can lead to loss of joint mobility, loss of function, peripheral nerve entrapment, and pressure sores. Read More

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http://dx.doi.org/10.1097/BRS.0000000000002680DOI Listing
November 2018
2 Reads

Percutaneous Endoscopic Spine Minimally Invasive Technique for Decompression Therapy of Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum.

World Neurosurg 2018 Jun 7;114:8-12. Epub 2018 Mar 7.

Department of Orthopaedic Surgery, The Affiliated Second Hospital of Nanchang University, Nanchang, Jiangxi, China. Electronic address:

Background: The percutaneous endoscopic technique through an interlaminar approach is a commonly used minimally invasive procedure in the treatment of lumbar disc herniation, even lumbar spinal stenosis. This report describes complete decompression with the percutaneous endoscopic technique for patients with thoracic ossification of the ligamentum flavum (OLF).

Case Description: We performed surgical decompression in of 2 patients with thoracic myelopathy caused by OLF using percutaneous endoscopic surgery through an interlaminar approach. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183042
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http://dx.doi.org/10.1016/j.wneu.2018.02.152DOI Listing
June 2018
16 Reads

A novel anterior decompression technique (vertebral body sliding osteotomy) for ossification of posterior longitudinal ligament of the cervical spine.

Spine J 2018 06 26;18(6):1099-1105. Epub 2018 Feb 26.

Department of Orthopedic Surgery, CHA Gumi Medical Center, CHA University, 12, Sinsi-ro 10-gil, Gumi-si, Gyeongsangbuk-do 39295, Republic of Korea. Electronic address:

Background Context: Conventional anterior decompression surgery for cervical myelopathy, including anterior corpectomy and fusion, is technically demanding and is known to be associated with a higher incidence of surgery-related complications, including cerebrospinal fluid (CSF) leakage, neurologic deterioration, and graft failure compared with posterior surgery.

Purpose: We introduce a novel anterior decompression technique (vertebral body sliding osteotomy [VBSO]) for cervical myelopathy caused by ossification of posterior longitudinal ligament (OPLL) and evaluate the efficacy and safety of this procedure.

Study Design: This is a case series for novel surgical technique. Read More

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http://dx.doi.org/10.1016/j.spinee.2018.02.022DOI Listing
June 2018
52 Reads

Surgical treatment of hip ankylosis due to heterotopic ossification secondary to spinal cord injury.

Rev Esp Cir Ortop Traumatol 2018 Nov - Dec;62(6):458-466. Epub 2018 Feb 22.

Servicio de Cirugía Ortopédica y Traumatología, Hospital Nacional de Parapléjicos, Toledo, España.

Objectives: To expose our experience in the diagnostic and surgical treatment of neurogenic heterotopic ossification of the hip.

Material And Methods: We designed an observational retrospective descriptive study including 20 patients (30 hips) with neurogenic heterotopic ossification of the hip secondary to spinal cord injury attended in our institution in the last 10 years, with a minimum of one year follow-up. Medical files and imaging studies were reviewed. Read More

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http://dx.doi.org/10.1016/j.recot.2018.01.003DOI Listing
February 2018

Extensive Bilateral Patellar Tendon Ossification in a Spinal Cord Injury Patient.

Acta Med Okayama 2018 Feb;72(1):89-93

Department of Orthopedic Surgery, Unnan City Hospital, Unnan, Shimane 699-1221,

This is the first report of extensive bilateral patellar tendon ossification occurring over a prolonged time after a unilateral knee injury. An 84-year-old Japanese man with a spinal cord injury caused by a burst fracture of the T12 vertebra presented with a bony hard prominence on the left knee, which was injured in a traffic accident when he was 77 years old. Radiography revealed extensive ossification of the bilateral patellar tendons. Read More

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http://dx.doi.org/10.18926/AMO/55670DOI Listing
February 2018
5 Reads

[French door segmented laminectomy decompression for severe cervical ossification of posterior longitudinal ligament complicated with spinal cord injury].

Zhongguo Gu Shang 2017 Sep;30(9):844-848

Department of Spinal Surgery, Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China;

Objective: To evaluate the clinical effects of French door segmented laminectomy decompression for severe cervical OPLL complicated with spinal cord injury.

Methods: The clinical data of 38 patients with serious cervical OPLL complicated with spinal cord injury were retrospectively analyzed and these patients were treated with French door segmented laminectomy decompression and internal fixation from June 2012 to June 2014. There were 25 males and 13 females, aged from 42 to 78 years with an average of 58. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2017.09.012DOI Listing
September 2017
7 Reads

Ossified extradural en-plaque meningioma of the cervical spine.

J Clin Neurosci 2018 Apr 14;50:124-126. Epub 2018 Feb 14.

Department of Neurological Surgery, Juntendo University Urayasu Hospital, Japan.

A 57-year-old woman sustained gradually progressive sensorimotor disturbance in the left upper extremity for one year. Neurological examination found a diminished sensation below the left C7 dermatome and reduced strength in the left interosseous muscles. Computed tomography of the cervical spine revealed a high density mass at C7, in the left dorsal part of the spinal canal. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.01.058DOI Listing
April 2018
24 Reads

Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice.

Nat Commun 2018 02 7;9(1):551. Epub 2018 Feb 7.

Department of Orthopedic Surgery, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.

Acquired heterotopic ossification (HO) is a painful and debilitating disease characterized by extraskeletal bone formation after injury. The exact pathogenesis of HO remains unknown. Here we show that TGF-β initiates and promotes HO in mice. Read More

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http://www.nature.com/articles/s41467-018-02988-5
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http://dx.doi.org/10.1038/s41467-018-02988-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803194PMC
February 2018
9 Reads

Local Spinal Cord Decompression Through a Full Endoscopic Percutaneous Transcorporeal Approach for Cervicothoracic Ossification of the Posterior Longitudinal Ligament at the T1-T2 Level.

World Neurosurg 2018 Apr 2;112:287-293. Epub 2018 Feb 2.

Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China. Electronic address:

Objective: To describe a percutaneous full endoscopic transcorporeal procedure to excise local ossification of the posterior longitudinal ligament (OPLL) lesions and decompress the spinal cord at the cervicothoracic transitional segment is safe and effective with respect to surgical complications.

Methods: A 67-year-old woman presented with nuchal pain and numbness below the T2 dermatome for 3 months and a 2-week history of paraplegia. T1-T2 myelopathy and paraplegia caused by OPLL was diagnosed based on clinical presentation, computed tomography, and magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.01.099DOI Listing
April 2018
9 Reads

Anterior cervical corpectomy and fusion versus posterior laminoplasty for the treatment of oppressive myelopathy owing to cervical ossification of posterior longitudinal ligament: a meta-analysis.

Eur Spine J 2018 06 15;27(6):1375-1387. Epub 2018 Jan 15.

Department of Orthopedics, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.

Purpose: The purpose of this research is to compare the clinical efficacy, postoperative complication and surgical trauma between anterior cervical corpectomy and fusion versus posterior laminoplasty for the treatment of oppressive myelopathy owing to cervical ossification of the posterior longitudinal ligament (OPLL).

Study Design: Systematic review and meta-analysis.

Methods: An comprehensive search of literature was implemented in three electronic databases (Embase, Pubmed, and the Cochrane library). Read More

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http://dx.doi.org/10.1007/s00586-017-5451-6DOI Listing
June 2018
30 Reads

Circulating osteogentic precursor cells in non-hereditary heterotopic ossification.

Bone 2018 04 3;109:61-64. Epub 2018 Jan 3.

Department of Medicine, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

Non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, central nervous system (CNS) injury, or surgery. We previously described circulating osteogenic precursor (COP) cells as a bone marrow-derived type 1 collagenCD45subpopulation of mononuclear adherent cells that are able of producing extraskeletal ossification in a murine in vivo implantation assay. In the current study, we performed a tissue analysis of COP cells in NHHO secondary to defined conditions, including traumatic brain injury, spinal cord injury, cerebrovascular accident, trauma without neurologic injury, and joint arthroplasty. Read More

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http://dx.doi.org/10.1016/j.bone.2017.12.028DOI Listing
April 2018
6 Reads

Histopathology of periarticular non-hereditary heterotopic ossification.

Bone 2018 04 7;109:65-70. Epub 2017 Dec 7.

Department of Medicine, Mayo Clinic School of Medicine, Mayo Clinic, Rochester, MN, United States. Electronic address:

In the mature adult skeleton, new bone formation is normally restricted to regeneration of osseous tissue at sites of fracture. However, heterotopic ossification, or the formation of bone outside the normal skeleton, can occur within muscle, adipose, or fibrous connective tissue. Periarticular non-hereditary heterotopic ossification (NHHO) may occur after musculoskeletal trauma, following CNS injury, with certain arthropathies, or following injury or surgery that is often sustained in the context of age-related pathology. Read More

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http://dx.doi.org/10.1016/j.bone.2017.12.006DOI Listing
April 2018
15 Reads

Radiological manifestations and surgical outcome of combined upper cervical cord compression and cervical ossification of the posterior longitudinal ligament with a minimum 2-year follow-up.

Medicine (Baltimore) 2017 Nov;96(45):e8332

aDepartment of Orthopedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou bDepartment of Orthopedics, Suichang People's Hospital, Lishui, P.R. China.

Combined upper cervical cord compression associated with cervical ossification of the posterior longitudinal ligament (OPLL) is a rare and under-recognized disorder. The aim of this study was to investigate the radiological manifestations and surgical outcome of this combined disease.Between May 2011 and July 2015, patients who underwent surgery for combined upper cervical cord compression and cervical OPLL in our institution were included in this study. Read More

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http://dx.doi.org/10.1097/MD.0000000000008332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690707PMC
November 2017
13 Reads

Association of α2-HS Glycoprotein with Neurogenic Heterotopic Ossification in Patients with Spinal Cord Injury.

Med Sci Monit 2017 Nov 12;23:5382-5388. Epub 2017 Nov 12.

Department of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland).

BACKGROUND The aim of this study was to explore the relationship between the α2-HS glycoprotein concentrations in serum and the occurrence of neurogenic heterotopic ossification (NHO) in patients with spinal cord injury (SCI). MATERIAL AND METHODS During the period between January 2011 and January 2012, 75 patients (67 male) with paraplegia caused by spinal cord injury were enrolled. The patients were divided into 2 groups in accordance with the occurrence of heterotopic ossification based on the results high-frequency ultrasound on the bilateral hip joint. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699169PMC
November 2017
7 Reads

Rapid Progression of Ossification of the Posterior Longitudinal Ligament After Anterior Cervical Discectomy and Fusion.

World Neurosurg 2018 02 28;110:11-16. Epub 2017 Oct 28.

Swedish Neuroscience Institute, Swedish Medical Center, Seattle, Washington, USA; Seattle Science Foundation, Seattle, Washington, USA; Department of Trauma Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany.

Background: Ossification of the posterior longitudinal ligament (OPLL) has a reported incidence of 1.9%-4.3%. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.10.105DOI Listing
February 2018
9 Reads

Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications.

JCI Insight 2017 Nov 2;2(21). Epub 2017 Nov 2.

Inserm UMR-S-MD1197, Paris 11 University, Paul Brousse Hospital, Villejuif, France.

Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in muscles surrounding joints following spinal cord or brain injury. We investigated the mechanisms of NHO formation in 64 patients and a mouse model of spinal cord injury-induced NHO. We show that marrow from human NHOs contains hematopoietic stem cell (HSC) niches, in which mesenchymal stromal cells (MSCs) and endothelial cells provide an environment supporting HSC maintenance, proliferation, and differentiation. Read More

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http://dx.doi.org/10.1172/jci.insight.96034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752299PMC
November 2017
25 Reads

Peripheral denervation participates in heterotopic ossification in a spinal cord injury model.

PLoS One 2017 30;12(8):e0182454. Epub 2017 Aug 30.

University of Versailles Saint Quentin en Yvelines, U1179 INSERM, UFR des Sciences de la Santé - Simone Veil, Montigny-le-Bretonneux, France.

We previously reported the development of a new acquired neurogenic HO (NHO) mouse model, combining spinal cord transection (SCI) and chemical muscle injury. Pathological mechanisms responsible for ectopic osteogenesis after central neurological damage are still to be elucidated. In this study, we first hypothesized that peripheral nervous system (PNS) might convey pathological signals from injured spinal cord to muscles in NHO mouse model. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182454PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576715PMC
October 2017
47 Reads

Ultrasonographic diagnosis of heterotopic ossification and secondary nerve entrapments in a patient with spinal cord injury.

Med Ultrason 2017 Aug;19(3):338-339

Hacettepe University Medical School Department of Physical and Rehabilitation Medicine, Ankara, Turkey.

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http://dx.doi.org/10.11152/mu-1121DOI Listing
August 2017
4 Reads

Lumbar idiopathic intervertebral disc calcification associated with ossification of the ligamentum flavum in adult: a case report.

Authors:
Danjie Zhu Yu Chen

Br J Neurosurg 2018 Oct 13;32(5):579-581. Epub 2017 Jul 13.

a Department of Orthopaedics , Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College , Hangzhou , Zhejiang , China.

A 23 year-old female was diagnosed with lumbar idiopathic intervertebral disc calcification associated with ossification of OLF. The patient underwent posterior decompression and posterolateral fusion with pedicle screw fixation, which achieved excellent clinical improvement. Surgical intervention of a posterior approach for decompression and instrumented fusion is indicated in cases that the spinal cord compression with neurologic deficits was involved. Read More

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https://www.tandfonline.com/doi/full/10.1080/02688697.2017.1
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http://dx.doi.org/10.1080/02688697.2017.1354120DOI Listing
October 2018
6 Reads

The traumatic bone: trauma-induced heterotopic ossification.

Transl Res 2017 08 15;186:95-111. Epub 2017 Jun 15.

Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, Md; The Department of Surgery, Uniformed Services University of the Health Sciences, Walter Reed National Military Medical Center, Bethesda, Md.

Heterotopic ossification (HO) is a common occurrence after multiple forms of extensive trauma. These include arthroplasties, traumatic brain and spinal cord injuries, extensive burns in the civilian setting, and combat-related extremity injuries in the battlefield. Irrespective of the form of trauma, heterotopic bone is typically endochondral in structure and is laid down via a cartilaginous matrix. Read More

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http://dx.doi.org/10.1016/j.trsl.2017.06.004DOI Listing
August 2017
16 Reads

Diffusion tensor imaging can predict surgical outcomes of patients with cervical compression myelopathy.

Eur Spine J 2017 09 16;26(9):2459-2466. Epub 2017 Jun 16.

Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana Chuou-ku, Chiba, Chiba, 260-8670, Japan.

Purpose: The aim of this study was to assess the potential role of diffusion tensor imaging (DTI) as a predictor of surgical outcomes in patients with cervical compressive myelopathy (CCM). Surgical decompression is often recommended for symptomatic CCM. It is important to know the prognosis of surgical outcomes and to recommend appropriate timing for surgery. Read More

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http://dx.doi.org/10.1007/s00586-017-5191-7DOI Listing
September 2017
9 Reads

Hyperphosphatemia in a patient with spinal cord injury who received etidronate for the treatment of heterotopic ossification.

Spinal Cord Ser Cases 2017 8;3:17032. Epub 2017 Jun 8.

Department of Physical Medicine and Rehabilitation, Ege University School of Medicine, Izmir, Turkey.

Introduction: Heterotopic ossification (HO) is defined as ectopic bone formation around peripheral joints and in soft tissues. HO is a common complication of diseases of the central nervous system, such as spinal cord injury (SCI) and traumatic brain injury. HO is seen in up to 50% of patients with SCI and typically occurs in the first 12 weeks after onset of injury. Read More

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http://dx.doi.org/10.1038/scsandc.2017.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463176PMC
June 2017
23 Reads

Neurological heterotopic ossification: Current understanding and future directions.

Bone 2018 04 16;109:35-42. Epub 2017 May 16.

Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC, 3010, Australia.

Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. NHO often forms around the hip, knee and shoulder joints, causing severe pain and joint deformation which is associated with significant morbidity and reduced quality of life. The cellular and molecular events that initiate NHO have been the focus of an increasing number of human and animal studies over the past decade, with this work largely driven by the need to unearth potential therapeutic interventions to prevent the formation of NHO. Read More

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http://dx.doi.org/10.1016/j.bone.2017.05.015DOI Listing
April 2018
35 Reads

Muscle localization of heterotopic ossification following spinal cord injury.

Spine J 2017 10 27;17(10):1519-1522. Epub 2017 Apr 27.

BG-University Hospital, Department of General and Trauma Surgery, BG-University Hospital Bergmannsheil, Bürkle-de-la-Camp Platz 1, 44789 Bochum, Germany.

Background Context: Heterotopic ossification (HO) is a known complication especially in people with traumatic spinal cord injury (SCI). Although some risk factors have already been described, the pathophysiology of HO is still unknown. The pelvis is the most common region for HO occurrence. Read More

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http://dx.doi.org/10.1016/j.spinee.2017.04.021DOI Listing
October 2017
17 Reads

Ossification of the Yellow Ligament Combined with Ossification of the Posterior Longitudinal Ligament at the Cervicothoracic Junction.

World Neurosurg 2017 Jul 24;103:952.e19-952.e22. Epub 2017 Apr 24.

Sakuragaoka Pathological Diagnostic Clinic, Kusatu-shi, Shiga, Japan.

Background: Both ossification of the yellow ligament (OYL) and the ossification of the posterior longitudinal ligament are relatively rare clinical entities. We report a extremely rare case of the spinal canal stenosis because of OYL, OPLL and listhesis at the cervicothoracic junction.

Case Description: A 69-year-old man had progressive pain over his bilateral axillar portion and right lower extremity for 1 year. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.04.097DOI Listing
July 2017
4 Reads

C4/5 foraminal stenosis predicts C5 palsy after expansive open-door laminoplasty.

Eur Spine J 2017 09 21;26(9):2340-2347. Epub 2017 Apr 21.

Department of Orthopaedic Surgery, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon, 35015, Republic of Korea.

Introduction: Laminoplasty is frequently performed in cervical myelopathy patients, but can lead to unexpected postoperative C5 palsy. Although several studies have examined the pathogenesis and prevention of postoperative C5 palsy, many controversies remain and some radiological findings identified as risk factors were not correlated with our outcomes.

Purpose: This study sought reliable radiological findings that predict C5 palsy after laminoplasty and examined why the predictors of C5 palsy did not apply in our series. Read More

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http://dx.doi.org/10.1007/s00586-017-5077-8DOI Listing
September 2017
25 Reads

An investigation of the relationship between autonomic dysreflexia and intrathecal baclofen in patients with spinal cord injury.

J Spinal Cord Med 2018 Jan 13;41(1):102-105. Epub 2017 Apr 13.

a MetroHealth Medical Center/MetroHealth Rehabilitation Institute of Ohio , Cleveland , OH , USA.

Objective: To study the relationship between autonomic dysreflexia and intrathecal baclofen in patients with spinal cord injury.

Design: Retrospective chart review.

Setting: Inpatient and outpatient acute rehabilitation facility. Read More

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http://dx.doi.org/10.1080/10790268.2017.1314878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810793PMC
January 2018
7 Reads

Diffuse idiopathic skeletal hyperostosis with cervical myelopathy.

CMAJ 2017 03;189(10):E410

Spinal Cord Injury Clinical Research Unit (Nouri), Toronto Western Hospital, University Health Network; Division of Neurosurgery, Department of Surgery, and Spinal Program (Fehlings), University of Toronto, Toronto, Ont.

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http://dx.doi.org/10.1503/cmaj.160487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359108PMC
March 2017
10 Reads

Predictive factors for neurological deterioration after surgical decompression for thoracic ossified yellow ligament.

Eur Spine J 2017 10 3;26(10):2598-2605. Epub 2017 Apr 3.

Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, Professorial Block, 5th Floor, 102 Pokfulam Road, Hong Kong, SAR, China.

Purpose: To investigate the rate and predictive factors of post-operative neurological deterioration in ossified yellow ligament (OYL) surgery.

Methods: A retrospective review was conducted for all patients with thoracic OYL causing myelopathy requiring surgical decompression from January 1998 to December 2012. Clinical parameters under study included clinical presentation, distribution of OYL, pre-operative walking score, pre- and post-operative neurological status, status of intra-operative neurophysiological monitoring, and modified Japanese Orthopaedic Association (mJOA) score. Read More

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http://dx.doi.org/10.1007/s00586-017-5078-7DOI Listing
October 2017
24 Reads

A case report of atypical long segmental thoracic hypertrophic pachymeningitis with ossification of ligamentum flavum and literature review.

Eur Spine J 2017 05 1;26(Suppl 1):202-206. Epub 2017 Apr 1.

Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Jiefang Street N88, Hangzhou, Zhejiang, China.

Background: Thoracic spinal stenosis caused by ossification of ligamentum flavum (OLF) is frequently seen, but long segmental thoracic spinal cord compressed by consequent thickened ligament posteriorly was rarely reported.

Object: To report a case of thoracic spinal cord compression caused by atypical long segmental thoracic hypertrophic pachymeningitis (HP) with OLF.

Methods: A 55-year-old woman presenting with weakness and numbness in lower extremities was admitted to our department. Read More

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http://dx.doi.org/10.1007/s00586-017-5030-xDOI Listing
May 2017
10 Reads

Prevalence of complications after surgery in treatment for cervical compressive myelopathy: A meta-analysis for last decade.

Medicine (Baltimore) 2017 Mar;96(12):e6421

aDepartment of Spinal Surgery, The Third Hospital of Hebei Medical University bHebei Provincial Key Laboratory of Orthopedic Biomechanics, Shijiazhuang, China.

Purpose: We aim to perform a meta-analysis on prevalence of all kinds of operation-related complications following surgery treating cervical compressive myelopathy (CCM) and to provide reference for surgeons making surgical plan.

Methods: An extensive search of literature was performed in PubMed/MEDLINE, Embase, the Cochrane library, CNKI, and WANFANG databases on incidence of operation-related complications from January 2007 to November 2016. Data was calculated and data analysis was conducted with STATA 12. Read More

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http://dx.doi.org/10.1097/MD.0000000000006421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371483PMC
March 2017
10 Reads

Descriptive study of earthquake-related spinal cord injury in Nepal.

Spinal Cord 2017 Jul 14;55(7):705-710. Epub 2017 Mar 14.

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Study Design: Descriptive study.

Objectives: To describe the epidemiological features of spinal cord injury (SCI) following the 2015 earthquakes in Nepal.

Setting: Spinal Injury Rehabilitation Centre, Kavre, Nepal. Read More

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http://www.nature.com/doifinder/10.1038/sc.2017.25
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http://dx.doi.org/10.1038/sc.2017.25DOI Listing
July 2017
7 Reads

Postoperative infections after excision of neurogenic heterotopic ossifications at the hip: Risk factors and causative organisms.

Orthop Traumatol Surg Res 2017 05 17;103(3):357-361. Epub 2017 Feb 17.

Service de chirurgie orthopédique et traumatologique, hôpital Raymond-Poincaré, 104, boulevard Raymond-Poincaré, 92380 Garches, France.

Background: Neurogenic heterotopic ossification (NHO) is usually treated by surgical excision. Postoperative infection (POI) is a possible complication, whose epidemiology, causative organisms, and risk factors are poorly known. We therefore conducted a case-control study to (1) identify the risk factors for POI after surgical excision of NHO at the hip, (2) determine the frequency of POI, (3) and identify the causative organisms. Read More

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http://dx.doi.org/10.1016/j.otsr.2017.02.001DOI Listing
May 2017
1 Read

Effects of Radiation Therapy on Established Neurogenic Heterotopic Ossification.

Ann Rehabil Med 2016 Dec 30;40(6):1135-1139. Epub 2016 Dec 30.

Department of Rehabilitation Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.

Heterotopic ossification (HO) is frequently seen on rehabilitation units after spinal cord injuries, fractures, brain injuries, and limb amputations. Currently, there is no effective treatment for HO other than prophylaxis with anti-inflammatory medications, irradiation, and bisphosphonate administration. These prophylactic treatments are not effective for managing ectopic bone once it has formed. Read More

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http://dx.doi.org/10.5535/arm.2016.40.6.1135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256336PMC
December 2016
39 Reads

Pressure ulcer reconstruction in patients with heterotopic ossification after spinal cord injury: A case series and review of literature.

J Plast Reconstr Aesthet Surg 2017 Apr 21;70(4):518-528. Epub 2016 Dec 21.

Department of Plastic Surgery, Medical College of Wisconsin, 1155 N. Mayfair Rd, Second Floor, Wauwatosa, WI 53226, United States.

Heterotopic ossification (HO) is widely recognized as a common occurrence among patients suffering from traumatic spinal cord injuries (SCI). The exact etiology of HO formation remains unknown. Published medical and surgical management strategies are often plagued with questionable effectiveness and frequent complications. Read More

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http://dx.doi.org/10.1016/j.bjps.2016.11.026DOI Listing
April 2017
5 Reads

Pre-surgical CT-assessment of neurogenic myositis ossificans of the hip and risk factors of recurrence: a series of 101 consecutive patients.

BMC Musculoskelet Disord 2016 10 18;17(1):433. Epub 2016 Oct 18.

APHP, Radiology Department, Neuro-musculoskeletal Pole, Raymond Poincaré Hospital, 92380, Garches, France.

Background: Neurogenic Myositis Ossificans (NMO) is a rare disabling pathology characterized by peri-articular heterotopic ossifications following severe peripheral or central nervous system injuries. It results in ankylosis and vessels or nerves compressions. Our study aimed to describe the pre-operative findings of patients with NMO of the hip using biphasic computerized tomography (CT). Read More

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http://dx.doi.org/10.1186/s12891-016-1294-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070170PMC
October 2016
12 Reads

Ankylosing spondylitis does not increase the risk of neurogenic heterotopic ossification in patients with a spinal cord injury: a retrospective cohort study.

Spinal Cord 2017 Feb 18;55(2):213-215. Epub 2016 Oct 18.

Department of Spinal Cord Injury, BG-University Hospital Bergmannsheil, Ruhr-University Bochum, Bochum, Germany.

Study Design: Retrospective chart review.

Objectives: The present study was performed to analyze the impact of ankylosing spondylitis (AS) in developing heterotopic ossification (HO) in patients following spinal cord injury.

Setting: Department of Spinal Cord Injury and Department of General and Trauma Surgery, BG-University Hospital Bergmannsheil Bochum, Ruhr-University Bochum, Germany. Read More

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http://www.nature.com/articles/sc2016143
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http://dx.doi.org/10.1038/sc.2016.143DOI Listing
February 2017
4 Reads