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Nature 2018 Dec 5. Epub 2018 Dec 5.

Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.

Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need. Xenotransplantation of genetically modified pig hearts has been discussed as a potential alternative. Genetically multi-modified pig hearts that lack galactose-α1,3-galactose epitopes (α1,3-galactosyltransferase knockout) and express a human membrane cofactor protein (CD46) and human thrombomodulin have survived for up to 945 days after heterotopic abdominal transplantation in baboons. Read More

Transpl Immunol 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.

Background: Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown.

Methods: A murine heterotopic tracheal transplantation model was used. Protein concentrations of HMGB1, interferon-γ (IFN-γ), interleukin (IL)-10, and IL-17 were analyzed in the isografts, allografts, controls, and HMGB1-neutralizing antibody administered allografts (n = 6; Days 1, 3, 5, 7, 14, 21, and 28). Read More

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Background: Cleidocranial dysplasia (CCD) in humans is an autosomal-dominant skeletal dysplasia caused by heterozygous mutations of the runt-related transcription factor 2 (RUNX2) and significantly increases the risk of osteoporosis. Increasing evidence demonstrates that the dysfunction of bone marrow stromal cells from CCD patients (BMSCs-CCD) contributes to the bone deficiency, but the characteristics of BMSCs-CCD and the mechanisms that underlie their properties remain undefined.

Methods: The clinical manifestations of three CCD patients were collected and the mutations of RUNX2 were analyzed. Read More

Indian J Plast Surg 2018 May-Aug;51(2):252-254

Department of Reconstructive Surgery, Lilavati Hospital and Research Centre, Mumbai, Maharashtra, India.

PLoS One 2018 5;13(12):e0208122. Epub 2018 Dec 5.

Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, United States of America.

Delivering therapeutics across the blood-brain barrier (BBB) for treating central nervous system (CNS) diseases is one of the biggest challenges today as the BBB limits the uptake of molecules greater than 500 Da into the CNS. Here we describe a novel trans-nasal mucosal drug delivery as an alternative to the intranasal drug delivery to overcome its limitations and deliver high molecular weight (HMW) therapeutics efficiently to the brain. This approach is based on human endoscopic skull base surgical techniques in which a surgical defect is repaired by engrafting semipermeable nasal mucosa over a skull base defect. Read More

J Bone Joint Surg Am 2018 Dec;100(23):2066-2072

Department of Orthopedic Surgery, Gumi CHA University Hospital, Gumi, South Korea.

Background: Although simple posterolateral or posterior elbow dislocations are relatively common and usually stable after closed reduction, simple posteromedial dislocations are extremely rare and poorly characterized. We investigated the clinical characteristics, soft-tissue injury patterns, treatments, and outcomes of a series of posteromedial elbow dislocations without relevant osseous lesions.

Methods: We retrospectively reviewed 20 cases of simple posteromedial elbow dislocations without relevant osseous lesions that were treated at 7 fellowship training hospitals during a 10-year period. Read More

Calcif Tissue Int 2018 Dec 4. Epub 2018 Dec 4.

Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, 1215 21st Ave. South, Suite 4200 MCE, South Tower, Nashville, TN, 37232, USA.

Heterotopic ossification (HO), or the pathologic formation of bone within soft tissues, is a significant complication following severe injuries as it impairs joint motion and function leading to loss of the ability to perform activities of daily living and pain. While soft tissue injury is a prerequisite of developing HO, the exact molecular pathology leading to trauma-induced HO remains unknown. Through prior investigations aimed at identifying the causative factors of HO, it has been suggested that additional predisposing factors that favor ossification within the injured soft tissues environment are required. Read More

World J Clin Cases 2018 Nov;6(14):847-853

Department of Pediatric Surgery, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.

Heterotopic pancreas (HP) is a congenital anomaly defined as pancreatic tissue that has no contact with the orthotopic pancreas and its own duct system and vascular supply. The most common locations of HP are the upper gastrointestinal tract, specifically, the stomach, duodenum, and proximal jejunum. Involvement of the mesentery is rare. Read More

Br J Clin Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California, San Francisco, CA.

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease in which heterotopic bone forms in muscle and soft tissue, leading to joint dysfunction and significant disability. FOP is progressive and many patients are wheelchair-bound by the third decade of life. FOP is caused by an activating mutation in the ACVR1 gene, which encodes the activin A Type 1 receptor. Read More

Pathol Oncol Res 2018 Nov 29. Epub 2018 Nov 29.

Institute for Clinical and Biomedical Research (iCBR), area of Environment Genetics and Oncobiology (CIMAGO), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

This study aimed to characterize endometrial cancer regarding cancer stem cells (CSC) markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism. Endometrial cancer cell line ECC1 was submitted to sphere forming protocols. The first spheres generation (ES1) was cultured in adherent conditions (G1). Read More

Clin J Gastroenterol 2018 Nov 29. Epub 2018 Nov 29.

Department of Surgery, School of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.

Heterotopic tissue in the bile duct is a very rare condition. There are a few case reports of heterotopic tissue including gastric and pancreatic cells. However, we could not find any data regarding heterotopic chondroid tissue obstructing the common bile duct in the literature. Read More

Med Mol Morphol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology, Osaka Dental University, 8-1 Kuzuhahanazono-cho, Hirakata, Osaka, 573-1121, Japan.

Most facial bones, including frontal bones, are derived from neural crest cells through intramembranous ossification. Fibroblast growth factor receptor 1 (Fgfr1) plays a pivotal role in craniofacial bone development, and loss of Fgfr1 leads to cleft palate and facial cleft defects in newborn mice. However, the potential role of the Fgfr1 gene in neural crest cell-mediated craniofacial development remains unclear. Read More

OTO Open 2017 Jul-Sep;1(3):2473974X17719022. Epub 2017 Jul 3.

Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.

Semin Diagn Pathol 2018 Nov 16. Epub 2018 Nov 16.

Departments of Pathology, Laboratory Medicine, and Neuroscience, 171 Ashley Avenue, MSC 908 Medical University of South Carolina, Charleston, SC 29425-9080, United States. Electronic address:

Hamartomas are an overgrowth of mature tissues that normally occur in an area of the body, but with disorganization and often with one element predominating. Choristomas on the other hand, are a mass of tissue histologically normal for a part of the body other than the one in which it is located (heterotopic/ectopic). Many reports use choristoma and heterotopia interchangeably. Read More

J Pathol Transl Med 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Patients with Beckwith-Wiedemann syndrome (BWS) are predisposed to developing embryonal tumors, with hepatoblastoma being the most common type. Our patient showed hemihypertrophy, macroglossia, and paternal uniparental disomy in chromosome 11 and was diagnosed with BWS. When the patient was nine months old, a 2. Read More

Transpl Immunol 2018 Nov 22. Epub 2018 Nov 22.

Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Health, and Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China. Electronic address:

Background: After lung transplantation, the major complication limiting the long-term survival of allografts is obliterative bronchiolitis (OB), characterized by chronic rejection. Innate immune responses contribute to the development of OB. In this study, we used a murine heterotopic tracheal transplantation mouse model to examine the effects of a newtype of innate immune inhibitor, TJ-M2010-5. Read More

Endoscopy 2018 Nov 23. Epub 2018 Nov 23.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan.

J Stroke Cerebrovasc Dis 2018 Nov 19. Epub 2018 Nov 19.

Sarah Network Rehabilitation Hospitals, Macapá, Amapá, Brazil. Electronic address:

Background And Purpose: The aim of this study was to evaluate heterotopic ossification (HO) prevalence after stroke, describing clinical features and investigating predictors of HO and its severity.

Methods: A cross-sectional study was carried out in 7 rehabilitation centers (Sarah Network) from 2004 to 2013.

Results: Among 17,794 stroke cases, 235 patients (1. Read More

Bone Joint Res 2018 Oct 3;7(10):570-579. Epub 2018 Nov 3.

UCLA Medical Center, Santa Monica David Geffen School of Medicine at UCLA, Los Angeles, USA.

Aims: Calcium sulphate has traditionally been used as a filler of dead space arising during surgery. Various complications have been described following the use of Stimulan bio-absorbable calcium sulphate beads. This study is a prospective observational study to assess the safety profile of these beads when used in revision arthroplasty, comparing the complication rates with those reported in the literature. Read More

PLoS One 2018 21;13(11):e0207272. Epub 2018 Nov 21.

Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United States of America.

The liver's regenerative capacity is unique, but too small a segment can overwhelm its ability to simultaneously regenerate and support the host, resulting in liver dysfunction and death. Here we tested a temporary Xenogeneic Heterotopic Auxiliary Liver Transplant (XHALT) from Gal-KO miniature swine in a baboon model of Post-Hepatectomy Liver Failure (PHLF) by 90%- hepatectomy. Immunosuppression consisted of CVF, ATG, FK 506 and steroids. Read More

Acta Orthop Belg 2018 Jun;84(2):117-120

The aim of this study was to compare radiological and clinical outcomes of posterior wall acetabulum fractures and posterior wall fracture dislocations. Data were including 52 acetabulum fractures and fracture dislocations. 26 patients (%50) had posterior acetabulum fractures and fracture dislocations who were operatively treated. Read More

Front Cardiovasc Med 2018 6;5:155. Epub 2018 Nov 6.

Bristol Medical School (Translational Health Sciences), Bristol Heart Institute, University of Bristol, Bristol, United Kingdom.

Cardiovascular calcification is an independent risk factor and an established predictor of adverse cardiovascular events. Despite concomitant factors leading to atherosclerosis and heart valve disease (VHD), the latter has been identified as an independent pathological entity. Calcific aortic valve stenosis is the most common form of VDH resulting of either congenital malformations or senile "degeneration. Read More

Turk J Gastroenterol 2018 Nov 19. Epub 2018 Nov 19.

Department of Radiology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey.

Heterotopic pancreas (HP) is localized pancreatic tissue that has no relation to orthotopic pancreas and has its own channel and vascular structures. Usually, the submucosa is located in the upper gastrointestinal tract; mesenteric placement is rarely reported. It is frequently asymptomatic and is detected incidentally in imaging, laparotomies, or autopsies. Read More

J Bone Miner Res 2018 Nov 20. Epub 2018 Nov 20.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Heterotopic ossification is the abnormal formation of mineralized bone in skin, muscle, tendon, or other soft tissues. Tendon ossification often occurs from acute tendon injury or chronic tendon degeneration, of which current treatment relies heavily on surgical removal of the ectopic bony tissues. Unfortunately, surgery creates additional trauma, which often causes recurrence of heterotopic ossification. Read More

Epilepsy Behav Case Rep 2019 9;11:4-9. Epub 2018 Oct 9.

Epilepsy Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

We describe a patient with unilateral periventricular nodular heterotopia (PNH) and drug-resistant epilepsy, whose SEEG revealed that seizures were arising from the PNH, with the almost simultaneous involvement of heterotopic neurons ("micronodules") scattered within the white matter, and subsequently the overlying cortex. Laser ablation of heterotopic nodules and the adjacent white matter rendered the patient seizure free. This case elucidates that "micronodules" scattered in white matter between heterotopic nodules and overlying cortex might be another contributor in complex epileptogenicity of heterotopia. Read More

Nat Chem 2018 Nov 19. Epub 2018 Nov 19.

College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials, Ministry of Education, Nankai University, Tianjin, China.

Heteromultivalency, which involves the simultaneous interactions of more than one type of ligand with more than one type of receptor, is ubiquitous in living systems and provides a powerful strategy to improve the binding efficiency of heterotopic species such as proteins and membranes. However, the design and development of artificial heteromultivalent receptors is still challenging owing to tedious synthesis processes and the need for precise control over the spatial arrangement of the binding sites. Here, we have designed a heteromultivalent platform by co-assembling cyclodextrin and calixarene amphiphiles, so that two orthogonal, non-covalent binding sites are distributed on the surface of the co-assembly. Read More

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):768-775

Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

To investigate the clinical features, diagnosis and treatments of heterotopic pregnancy (HP) and demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. A retrospective analysis was performed on 144 cases of HP in Womens Hospital, School of Medicine, Zhejiang University from January 2003 to December 2016. (1) Clinical features of HP:the average age of patients was (30. Read More

J Shoulder Elbow Surg 2018 Dec;27(12):e380-e386

Addenbrooke's Hospital, Cambridge, UK. Electronic address:

JCI Insight 2018 Nov 15;3(22). Epub 2018 Nov 15.

Division of Endocrinology and Metabolism, Department of Medicine, and the Institute for Human Genetics, UCSF, San Francisco, California, USA.

Background: Inflammation helps regulate normal growth and tissue repair. Although bone morphogenetic proteins (BMPs) and inflammation are known contributors to abnormal bone formation, how these pathways interact in ossification remains unclear.

Methods: We examined this potential link in patients with fibrodysplasia ossificans progressiva (FOP), a genetic condition of progressive heterotopic ossification caused by activating mutations in the Activin A type I receptor (ACVR1/ALK2). Read More

Rev Esp Cir Ortop Traumatol 2018 Nov 11. Epub 2018 Nov 11.

Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitari i Politècnic La Fe, Valencia, España.

Introduction: Acetabular fractures in elderly patients present a therapeutic challenge, since their osteosynthesis may be hindered by comminution and poor bone quality. In certain cases, a good solution is acute total hip arthroplasty (THA) by direct anterior approach with or without minimal associated osteosynthesis. The objective of this study was to establish the indications and evaluate the clinical/functional, radiological results and complications, in the short and medium term, of acute THA using an anterior approach after acetabular fractures. Read More

Int J Mol Sci 2018 Nov 13;19(11). Epub 2018 Nov 13.

Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, Saitama 350-1241, Japan.

Bone is a unique organ because it can be experimentally induced in soft tissues by implanting a single growth factor, bone morphogenetic protein (BMP). Heterotopic bone-inducing activity was found in demineralized bone matrix in 1965. The characterization of this activity in bone enabled the purification and molecular cloning of BMPs and showed that they are members of the transforming growth factor-β (TGF-β) superfamily. Read More

J Biomater Appl 2018 Nov 14:885328218811386. Epub 2018 Nov 14.

4 Ecole Polytechnique de Montreal, 2900 Boul Edouard-Montpetit, Montreal, Canada.

Rotator cuff tears result in shoulder pain, stiffness, weakness and loss of motion. After surgical repair, high failure rates have been reported based on objective imaging and it is recognized that current surgical treatments need improvement. The aim of the study was to assess whether implants composed of freeze-dried chitosan (CS) solubilized in autologous platelet-rich plasma (PRP) can improve rotator cuff repair in a rabbit model. Read More

Acta Orthop Belg 2017 Dec;83(4):544-549

The aim of this study was to compare radiological and clinical outcomes of posterior wall acetabulum fractures and posterior wall fracture dislocations. Data were including 52 acetabulum fractures and fracture dislocations. Twenty-six patients (%50) had posterior acetabulum fractures and fracture dislocations who were operatively treated. Read More

Histol Histopathol 2018 Nov 13:18062. Epub 2018 Nov 13.

School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Wnt signaling, canonical or non-canonical, plays conserved roles in numerous physiological and pathological processes. However, it is well beyond the scope of this review to cover all functional aspects of Wnt signaling in different contexts at reasonable depth; therefore this review intends to cover only the roles of Wnt signaling in bone biology; more specifically, we intend to first update the roles of Wnt signaling in physiological bone process, including in osteogenesis and chondrogenesis, since recent years have witnessed tremendous progressions in this area, and then we seek to extend our understanding to the pathological bone process, especially to the heterotopic ossification (HO), even though the understanding of Wnt signaling in HO has been limited. We then further clarify the potential crosstalking between Wnt and other conserved signaling pathways, including FGF, GPCR and Hif1α pathways. Read More

Case Rep Obstet Gynecol 2018 21;2018:6478589. Epub 2018 Oct 21.

Montefiore Medical Center, Department of Obstetrics & Gynecology and Women's Health, Bronx, NY, USA.

Background: Heterotopic pregnancy involving the implantation of an ectopic pregnancy into a prior cesarean scar with a concurrent intrauterine pregnancy is a rare and potentially life-threatening condition with minimal information in the literature to guide treatment and management options.

Case: A 40-year-old G5P3103 at 12 weeks and 3 days with a history of two cesarean deliveries was diagnosed with a live heterotopic pregnancy containing a cesarean scar ectopic and an intrauterine pregnancy. After selective reduction of the cesarean scar gestation with potassium chloride (KCl), the patient presented ten days later to the emergency department with septic abortion and sepsis. Read More

BMJ Case Rep 2018 Nov 12;2018. Epub 2018 Nov 12.

Department of Radiology, Shiraz University of Medical Sciences, Shiraz, The Islamic Republic of Iran.

Splenosis is the heterotopic implantation of splenic tissue that usually occurs in a previous major abdominal trauma or splenectomy setting. However, splenorenal fusion is an uncommon entity, categorised as a developmental anomaly. There have been several confirmed cases in the literature. Read More

Korean J Gastroenterol 2018 Oct;72(4):213-216

Health Promotion Center, Dongkang Medical Center, Ulsan, Korea.

The occurrence of heterotopic tissue in the large intestine is unusual. The most common heterotopic tissue type described is gastric-type mucosa. On the other hand, heterotopic salivary gland tissue in the large intestine is extremely rare. Read More

J Cell Physiol 2018 Nov 11. Epub 2018 Nov 11.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.

Fibrodysplasia ossificans progressiva (FOP) is a genetic disease characterized by heterotopic ossification (HO). The disease is caused by a mutation in the activin receptor type 1 (ACVR1) gene that enhances this receptor's responsiveness to Activin-A. Binding of Activin-A to the mutated ACVR1 receptor induces osteogenic differentiation. Read More

J Obstet Gynaecol India 2018 Dec 12;68(6):505-507. Epub 2017 Sep 12.

Department of Obstetrics and Gynecology, KEM Hospital, Pune, India.

Background: Heterotopic pregnancy (HP) is a condition characterized by the coexistence of multiple fetuses at two or more implantation sites. It occurs in 1% of pregnancies after assisted reproductive techniques (ART). Presence of triplet intrauterine pregnancy with ectopic gestational sac is one of the rarest forms of HP. Read More

J Minim Access Surg 2018 Nov 9. Epub 2018 Nov 9.

Department of General Surgery, Seth GS Medical College and King Edward Memorial Hospital, Mumbai, Maharashtra, India.

Background: Laparoscopic techniques have been used during pregnancy by obstetricians since the 1970's, primarily to diagnose and treat ectopic and heterotopic pregnancies. Pregnancy was considered as an absolute contraindication to laparoscopy by surgeons as recently as 1991, and a few still doubt the safety of minimal access in gravid patients. When an emergent operation is indicated, the surgery should not be withheld on the sole basis of patient's gravid state. Read More

Injury 2018 Nov;49 Suppl 3:S100-S104

San Carlo di Nancy Hospital, GVM Care and Research, Rome, Italy. Electronic address:

Injuries of the rectus femoris tendon origin could result in a chronic tendinopathy, leading to groin pain and loss of function. Conservative treatment with analgesics and physical therapy is the gold standard, but in some cases excessive bone formation after avulsion injuries, can lead to a post-traumatic heterotopic ossification (PHO) and may benefit from surgical removal.

Methods: Outcome was evaluated in 16 top soccer players (age 24-43 years) affected by calcification of the proximal rectus who underwent arthroscopic excision (6-12 and 24 months). Read More

Arch Orthop Trauma Surg 2018 Nov 11. Epub 2018 Nov 11.

Department of Orthopedics, Paracelsus Klinik Osnabrück, Osnabrück, Germany.

Introduction: The minimally invasive direct anterior approach (DAA) is an established approach for primary total hip arthroplasty (THA). The complication rates in hip revision arthroplasty are much higher in comparison with primary THA. A right positioning of the implants and a soft tissue, especially the abductors spearing approach, is important to get good functional results and low complication rates. Read More

Dig Dis Sci 2018 Nov 10. Epub 2018 Nov 10.

Department of Gastroenterology, Hepatology, and Nutrition, University of Texas - MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030-4009, USA.

Malignant transformation of ectopic pancreas tissue is a diagnostic challenge as clinical symptoms and radiographic features of these tumors are non-specific. Given the rarity of these lesions, it is usually neither suspected nor included in the diagnostic workup of different tumors. We conducted a comprehensive literature review regarding malignancy arising from ectopic pancreas for a better understanding of its frequency, clinicopathological features, and prognosis. Read More

World Neurosurg 2018 Nov 8. Epub 2018 Nov 8.

Department of Operation room, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, China.

Objective: Present the long-term clinical and radiographic comparison between the Prestige-LP cervical disc replacement and the Zero-p spacer cervical disc fusion in treatment of patients with symptomatic two-level cervical degenerative disease.

Methods: 36 patients in the ACDF group and 24 patients in the CDA group were analyzed before surgery and at 1 week, 3, 6, 12, 24 and 60 months after surgery. Clinical assessments included Japanese Orthopedic Assessment (JOA), Visual Analog Scale (VAS), and Neck Disability Index (NDI) scores. Read More

Methods Mol Biol 2019 ;1891:247-255

Department of Orthopaedic Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder of progressive extra-skeletal ossification, is the most disabling form of heterotopic ossification (HO) in humans. Most people with FOP carry an activating mutation in a BMP type I receptor gene, ACVR1 , that promotes ectopic chondrogenesis and osteogenesis and in turn HO. Advances in elucidating the cellular and molecular events and mechanisms that lead to the ectopic bone formation are being made through the use of genetically engineered mouse models that recapitulate the human disease. Read More

Methods Mol Biol 2019 ;1891:155-163

Program in Cell, Molecular, and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA.

Fibrodysplasia ossificans progressiva (FOP) is a rare human skeletal disease caused by constitutively activating mutations in the gene ACVR1, which encodes a type I BMP/TGFβ family member receptor. FOP is characterized by progressive heterotopic ossification (HO) of fibrous tissues, including skeletal muscle, tendons, and ligaments, as well as malformation of the big toes, vertebral fusions, and osteochondromas. Surgical interventions in patients often result in enhanced HO, which can exacerbate rather than improve diagnostic outcomes. Read More

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Trauma and Orthopaedics, Royal Lancaster Infirmary, Lancaster, UK.

Heterotopic ossification (HO) is the abnormal growth of extraskeletal bone. Joint involvement may result in chronic stiffness and pain causing considerable functional impairment and the inability to perform the activities of daily living. HO affecting the shoulder joint is rare and little is known about its clinical course or treatment. Read More

Medicine (Baltimore) 2018 Oct;97(43):e13004

The Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Rationale: Meckel's diverticulum (MD) is common congenital abnormality of gastrointestinal tract, only about 6.4% of patients become symptomatic. A smaller minority develop potential fatal complications such as hemorrhage, perforation, abscess, and bowel obstruction. Read More

Int Orthop 2018 Nov 8. Epub 2018 Nov 8.

Service de chirurgie orthopédique, Unité Rachis 1, CHU Bordeaux Pellegrin, Bordeaux, France.

Purpose: Cervical disc herniation is a common pathology. It can be treated by different surgical procedures. We aimed to list and analyzed every available surgical option. Read More

Int J Angiol 2018 Dec 18;27(4):196-201. Epub 2018 Oct 18.

Department of Physiology and Pathophysiology, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba, Winnipeg, Canada.

Following heterotopic transplantation, the rat heart undergoes atrophy and exhibits delayed cardiac relaxation without any changes in contraction and systolic Ca transients. Furthermore, the sarcoplasmic reticular Ca uptake and release activities were reduced and Ca influx through L-type Ca channels was increased in the atrophied heart. Since Ca movements at sarcolemma are intimately involved in the regulation of intracellular Ca concentration, the present study was undertaken to test if sarcolemma plays any role to maintain cardiac function in the atrophied heart. Read More