10,789 results match your criteria Heterotopic Ossification


Stimulating Factors and Origins of Precursor Cells in Traumatic Heterotopic Ossification Around the Temporomandibular Joint in Mice.

Front Cell Dev Biol 2020 18;8:445. Epub 2020 Jun 18.

Department of Oral & Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, National Clinical Research Center for Oral Disease, Shanghai, China.

The contributing factors and the origins of precursor cells in traumatic heterotopic ossification around the temporomandibular joint (THO-TMJ), which causes obvious restriction of mouth opening and maxillofacial malformation, remain unclear. In this study, our findings demonstrated that injured chondrocytes in the condylar cartilage, but not osteoblasts in the injured subchondral bone, played definite roles in the development of THO-TMJ in mice. Injured condylar chondrocytes without articular disc reserves might secrete growth factors, such as IGF1 and TGFβ2, that stimulate precursor cells, such as endothelial cells and muscle-derived cells, to differentiate into chondrocytes or osteoblasts and induce THO-TMJ. Read More

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http://dx.doi.org/10.3389/fcell.2020.00445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314999PMC

Small molecule inhibition of non-canonical (TAK1-mediated) BMP signaling results in reduced chondrogenic ossification and heterotopic ossification in a rat model of blast-associated combat-related lower limb trauma.

Bone 2020 Jul 2:115517. Epub 2020 Jul 2.

Regenerative Medicine Department, Naval Medical Research Center, Silver Spring, MD, United States of America; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States of America. Electronic address:

Heterotopic ossification (HO) is defined as ectopic bone formation around joints and in soft tissues following trauma, particularly blast-related extremity injuries, thermal injuries, central nerve injuries, or orthopaedic surgeries, leading to increased pain and diminished quality of life. Current treatment options include pharmacotherapy with non-steroidal anti-inflammatory drugs, radiotherapy, and surgical excision, but these treatments have limited efficacy and have associated complication profiles. In contrast, small molecule inhibitors have been shown to have higher specificity and less systemic cytotoxicity. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115517DOI Listing

[Complex rehabilitation of a patient with marked motor and cognitive impairments after a brain injury].

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(5):88-92

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

In the presented case report, the complex approach of rehabilitation in the remote period of traumatic brain injury (TBI) allowed the achievement of the significant clinical effect. The authors analyzed the experience of reflex therapy in the treatment of TBI. The effectiveness and potential of acupuncture, objectification of the results are topical issues that require further research. Read More

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http://dx.doi.org/10.17116/jnevro202012005188DOI Listing

Patient Reported Outcomes of Femoral Head Fractures With Minimum 10-Year Follow-up.

J Orthop Trauma 2020 Jun 26. Epub 2020 Jun 26.

Hennepin County Medical Center, Minneapolis, MN, USA.

Objective: To evaluate the clinical and patient-reported outcomes of patients with femoral head fractures treated at a single level I trauma center with a minimum 10-year follow-up.

Design: Retrospective review SETTING:: Academic Level-1 Trauma Center PATIENTS/PARTICIPANTS:: One hundred and one consecutive femoral head fractures were identified for this study. The final study group consisted of 28 patients with a minimum of 10-years of clinical follow-up. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001880DOI Listing

Risk Factors for Elbow Joint Contracture After Surgical Repair of Traumatic Elbow Fracture.

J Am Acad Orthop Surg 2020 Jul 1. Epub 2020 Jul 1.

From the Department of Orthopedic Surgery, NYU Langone Orthopedic Hospital, New York, NY.

Purpose: The ability to predict contracture development after elbow fracture would benefit patients and physicians. This study aimed to identify factors associated with the development of posttraumatic elbow joint contracture.

Methods: A retrospective review of elbow fractures (AO/Orthopaedic Trauma Association [OTA] type 13 and 21) treated at one institution between 2011 and 2015 was performed. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00801DOI Listing

Local injection of a hexametaphosphate formulation reduces heterotopic ossification .

Mater Today Bio 2020 Jun 2;7:100059. Epub 2020 Jun 2.

Healthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, UK.

Heterotopic ossification (HO), the pathological formation of ectopic bone, is a debilitating condition which can cause chronic pain, limit joint movement, and prevent prosthetic limb fitting. The prevalence of this condition has risen in the military population, due to increased survivorship following blast injuries. Current prophylaxes, which aim to target the complex upstream biological pathways, are inconsistently effective ​and have a range of side-effects that make them unsuitable for combat-injured personnel. Read More

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http://dx.doi.org/10.1016/j.mtbio.2020.100059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322360PMC

Temporomandibular Joint Prosthesis Revision and/or Replacement Survey and Review of the Literature.

J Oral Maxillofac Surg 2020 May 20. Epub 2020 May 20.

Associate Professor and Program Director, Department of Oral and Maxillofacial Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX.

Purpose: The purpose of the present study was to report the temporomandibular joint (TMJ) alloplastic reconstruction (TMJR) revision and/or replacement rates and associated complication outcomes data gathered from experienced TMJ surgeons and to review the recent relevant data.

Materials And Methods: A 21-question anonymous on-line survey was sent to all Commission on Dental Accreditation-approved oral and maxillofacial surgery program directors and to members of the European Society of TMJ Surgeons and the American Society of Temporomandibular Joint Surgeons.

Results: Of the surgeons sent the survey, 22% completed the full questionnaire. Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.021DOI Listing

Anatomic coracoclavicular ligament reconstruction (ACCR) using free tendon allograft is effective for chronic acromioclavicular joint injuries at mid-term follow-up.

Knee Surg Sports Traumatol Arthrosc 2020 Jun 30. Epub 2020 Jun 30.

Department of Orthopaedic Surgery, UConn Health, Farmington, CT, USA.

Purpose: To evaluate the clinical and radiographic outcomes of patients undergoing anatomic coracoclavicular ligament reconstruction (ACCR) using free tendon allografts for the treatment of chronic acromioclavicular joint (ACJ) injuries with a minimum 1-year follow-up.

Methods: Patients who underwent ACCR for chronic ACJ injuries between 2003 and 2017 were analyzed. Clinical outcome measures included American Shoulder and Elbow Surgeons (ASES), Constant-Murley (CM), Simple Shoulder Test (SST), and Single Assessment Numerical Evaluation (SANE) scores. Read More

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http://dx.doi.org/10.1007/s00167-020-06123-0DOI Listing

Modified pararectus approach for treatment of atypical acetabular anterior wall fracture: A case report.

World J Clin Cases 2020 Jun;8(12):2634-2640

Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan Province, China.

Background: Acetabular anterior wall fracture with preservation of the pelvic brim is extremely rare. It is different from anterior wall fracture classified by Judet and Letournel. Few studies have reported cases treated by open reduction and internal fixation the Smith-Petersen or iliofemoral approach. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i12.2634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322424PMC

Goblet Cell Adenocarcinoma With Heterotopic Ossification: A Rare Case Report and Review of Literature.

Cureus 2020 May 27;12(5):e8312. Epub 2020 May 27.

Pathology and Laboratory Medicine, University of Louisville, Louisville, USA.

Heterotopic bone formation is a rare phenomenon when associated with gastrointestinal neoplasms. Here we present a rare case of heterotopic ossification associated with goblet cell adenocarcinoma of the appendix, and a literature review of such cases associated with neoplasms within and out of the gastrointestinal tracts. We reviewed the clinical data and when available, immunohistochemical markers of osteoblastic differentiation. Read More

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http://dx.doi.org/10.7759/cureus.8312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320657PMC

Ultrasound of Musculoskeletal Hematomas: Relationship of Sonographic Appearance to Age and Ease of Aspiration.

AJR Am J Roentgenol 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiology and Imaging, Hospital for Special Surgery, 535 E. 70th Street,, New York, NY 10021, Tel. 212-606-1000, Fax. 212-774-7475,

Hematomas can be managed conservatively, but aspiration can lead to decreased pain, decrease in heterotopic ossification, and earlier return to sports activities. The purpose of this study is to evaluate the safety and efficacy of ultrasound-guided aspiration of intramuscular hematomas, and to evaluate the associations between the sonographic appearance of hematomas and their age and ease of aspiration An IRB waiver-approved, retrospective search of our radiology database was conducted between 1/01/2008 - 9/28/2017. Associations between ease of aspiration with echotexture, age of the hematoma, hematoma location, and needle gauge were accessed with a marginal proportional logistic regression model estimated using generalized estimating equations (GEE), accounting for patients with multiple hematomas. Read More

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http://dx.doi.org/10.2214/AJR.19.22752DOI Listing

Total Hip Arthroplasty With a Monoblock Conical Stem in Dysplastic Hips: A 20-Year Follow-Up Study.

J Arthroplasty 2020 Jun 1. Epub 2020 Jun 1.

Hip Diseases and Joint Replacement Surgery Unit, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.

Background: Total hip arthroplasty in patients with hip dysplasia is challenging as a result of complex anatomic deformities in the hip. The aim of the study was to evaluate the survivorship, the clinical and radiographic outcomes of cementless Wagner Cone stem in patients with dysplastic hip.

Methods: This retrospective study reports on 102 patients (135 hips) who have undergone total hip arthroplasty between 1993 and 1997. Read More

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http://dx.doi.org/10.1016/j.arth.2020.05.069DOI Listing

Diffuse Neuritis Ossificans of the Brachial Plexus: Case report and review of the literature.

World Neurosurg 2020 Jun 26. Epub 2020 Jun 26.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Neuritis ossificans (intraneural heterotopic ossification) is a rare disorder described as heterotopic ossification of a nerve. We describe the presentation and management of the first reported case of neuritis ossificans with diffuse brachial plexus involvement and review the literature CASE DESCRIPTION: A 35-year-old man presented to our clinic for evaluation of right upper extremity weakness without history of trauma. He had significant, debilitating pain and magnetic resonance imaging demonstrated a complex contrast-enhancing mass with significant associated edema. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.154DOI Listing

The Distinct Role of the Extra-Large G Protein ɑ-Subunit XLɑs.

Calcif Tissue Int 2020 Jun 28. Epub 2020 Jun 28.

Laboratory of Endocrinology and Metabolism, Department of Endocrinology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, China.

GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Read More

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http://dx.doi.org/10.1007/s00223-020-00714-2DOI Listing

Traumatic myositis ossificans: multifocal lesions suggesting malignancy on FDG-PET/CT-a case report.

Skeletal Radiol 2020 Jun 25. Epub 2020 Jun 25.

Department of Oral Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.

Myositis ossificans (MO) is a benign soft-tissue lesion characterized by the heterotopic formation of the bone in skeletal muscles, usually due to trauma. MO is occasionally difficult to diagnose because of its clinical and radiological similarities with malignancy. We report a case of traumatic MO (TMO) in the masseter and brachial muscles of a 37-year-old man who presented with painless swelling in the left cheek and severe trismus. Read More

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http://dx.doi.org/10.1007/s00256-020-03521-wDOI Listing

Rehabilitation from meningioma.

Handb Clin Neurol 2020 ;170:323-331

Department of Physical Medicine and Rehabilitation, St. Mary's Medical Center, San Francisco, CA, United States. Electronic address:

This chapter discusses the complex process of acute rehabilitation of patients after meningioma. Acute inpatient rehabilitation after meningioma utilizes an interdisciplinary approach to provide comprehensive rehabilitation through a team of physical, occupational, and speech therapists, nurses, doctors, recreational therapists, neuropsychologists, case managers and social workers, all of whom specialize in providing rehabilitation care. The prognosis of rehabilitation outcomes in this population is similar to that of the stroke population, and patients benefit from rehabilitation to maximize function in the setting of ongoing treatment. Read More

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http://dx.doi.org/10.1016/B978-0-12-822198-3.00051-3DOI Listing
January 2020

Post-stroke bilateral heterotopic ossification: An acute problem with long-lasting consequences.

Jt Dis Relat Surg 2020 18;31(2):386-389. Epub 2020 Jun 18.

Başkent Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, 06490 Bahçelievler, Ankara, Türkiye.

Heterotopic ossification (HO) is a complication of injury to the central nervous system in which production of lamellar bone within the soft tissues occurs resulting in pain, reduced range of motion (ROM) and loss of functional capacity. Heterotopic ossification is rarely seen in stroke patients and mostly affects the paretic side. In this article, we present a case of established bilateral HO of the hips soon after stroke onset. Read More

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http://dx.doi.org/10.5606/ehc.2020.72081DOI Listing

Capitellum fractures: Treatment with headless screws and outcomes.

Jt Dis Relat Surg 2020 18;31(2):291-297. Epub 2020 Jun 18.

Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi Ortopedi ve Travmatoloji Kliniği, 34147 Bakırköy İstanbul, Türkiye.

Objectives: This study aims to present the results of 21 patients with capitellum fractures treated with open reduction and headless screws by a single experienced surgeon.

Patients And Methods: Twenty-one patients (13 males, 8 females; mean age 39 years; range, 18 to 63 years) who were admitted to our clinic between June 2011 and January 2018 with the diagnosis of capitellum fracture and followed-up for a mean period of 45 months (range, 12 to 90 months) were included in this retrospective study. The fractures were fixed with headless cannulated screws by a single surgeon. Read More

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http://dx.doi.org/10.5606/ehc.2020.72821DOI Listing

Aspirin used for venous thromboembolism prophylaxis in total hip arthroplasty decreases heterotopic ossification.

Arthroplast Today 2020 Jun 13;6(2):206-209. Epub 2020 Mar 13.

Department of Orthopaedic Surgery, Scripps Clinic, La Jolla, CA, USA.

Background: Heterotopic ossification (HO) is a known complication of total hip arthroplasty (THA) that can lead to persistent pain, stiffness, nerve impingement, and instability. Aspirin (ASA) has become an increasingly popular method of venous thromboembolism (VTE) prophylaxis, given its availability, ease of use, and relative safety. Although indomethacin has been commonly used for HO prophylaxis, we wanted to determine whether ASA, given the similar mechanism of action, may be effective in reducing the risk of HO in routine unilateral, primary THA when already being used for VTE prophylaxis. Read More

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http://dx.doi.org/10.1016/j.artd.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303487PMC

Comparing Heterotopic Ossification in Two Cervical Disc Prostheses.

Spine (Phila Pa 1976) 2020 Apr 23. Epub 2020 Apr 23.

Department of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands.

Study Design: Retrospective analysis using data from RCTs OBJECTIVE.: To compare the occurrence of heterotopic ossification (HO) between two cervical disc prostheses. Clinical outcome and range of motion (ROM) were also evaluated. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003537DOI Listing

Development of heterotopic ossification after multiple-ligament reconstruction of the knee joint: Incidence and explanatory factor analysis.

Knee 2020 Jun 30;27(3):642-648. Epub 2020 Apr 30.

Sports Medicine Service, Beijing Jishuitan Hospital, Beijing, China. Electronic address:

Background: The development of heterotopic ossification (HO) might nullify any benefit of multiple-ligament reconstruction of the knee joint. The purpose of this study was to investigate the incidence and the specific explanatory factors for the development of HO after multiple-ligament reconstruction of the knee joint.

Methods: From January 2011 to June 2016, 72 consecutive patients with knee dislocations received multiple-ligament reconstructions, of which 57 (79%) were available for a minimum follow up of 12 months and were included in this study. Read More

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http://dx.doi.org/10.1016/j.knee.2020.04.012DOI Listing

Matrine attenuates heterotopic ossification by suppressing TGF-β induced mesenchymal stromal cell migration and osteogenic differentiation.

Biomed Pharmacother 2020 Jul 18;127:110152. Epub 2020 May 18.

Department of Orthopedics, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214062, China. Electronic address:

Purpose Of The Study: Heterotopic ossification (HO) is a debilitating disease characterized by extraskeletal bone formation. Active TGF-β recruits mesenchymal stromal cells (MSCs), which contribute to trauma-induced HO. Inhibiting TGF-β induced MSC migration and osteogenic differentiation could be a promising treatment for HO. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110152DOI Listing

Reinsertion of distal biceps ruptures with a single anterior approach: analysis of 14 cases using tension-slide technique and interference screw.

Acta Biomed 2020 May 30;91(4-S):183-188. Epub 2020 May 30.

Department of Orthopedics and Traumatology, Policlinic of Modena, University of Modena and Reggio Emilia..

Background: Several techniques of surgical repair of biceps tendon ruptures are described in literature. Cortical button repair have shown minimal loss of elbow flexion, supination and strength. In this retrospective study we report the outcomes in terms of elbow function and complications of tension-slide technique and interference screw. Read More

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http://dx.doi.org/10.23750/abm.v91i4-S.9551DOI Listing

Direct anterior total hip arthroplasty: a retrospective study.

Acta Biomed 2020 May 30;91(4-S):98-102. Epub 2020 May 30.

Ospedale Pederzoli, Peschiera del Garda.

Background: The quest for less invasive surgical approaches for total hip arthroplasty has gained much attention recently. There is very little information regarding differences about the main surgical access. The purpose of this study was to collect data regarding patients' subjective perceptions of the direct anterior hip arthroplasty, heterotopic ossification degrees, range of movement and complication and comparing these satisfaction results with the other surgical techniques. Read More

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http://dx.doi.org/10.23750/abm.v91i4-S.9227DOI Listing

Outcome after the surgical treatment of the Dubberley type B distal humeral capitellar and trochlear fractures with a buttress plate.

Acta Orthop Traumatol Turc 2020 Jun 18. Epub 2020 Jun 18.

Clinic of Orthopaedics and Traumatology, Florence Nightingale Hospital, İstanbul, Turkey.

Objective: This study aimed to evaluate the functional outcomes of the surgical treatment performed with a buttress plate for the trochlear and distal capitellum fractures with posterior extension in the humerus.

Methods: The data belonging to 6 female and 4 male patients with a mean age of 43.8±11. Read More

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http://dx.doi.org/10.5152/j.aott.2020.20092DOI Listing

Activin A does not drive post-traumatic heterotopic ossification.

Bone 2020 Jun 15;138:115473. Epub 2020 Jun 15.

Department of Surgery, University of Michigan, Ann Arbor, MI, United States of America; Division of Plastic Surgery, Department of Surgery, University of Michigan Health System, 1500 E Medical Center Drive, SPC 5340, Ann Arbor, MI 48109-5340, United States of America. Electronic address:

Heterotopic ossification (HO), the formation of ectopic bone in soft tissues, has been extensively studied in its two primary forms: post-traumatic HO (tHO) typically found in patients who have experienced musculoskeletal or neurogenic injury and in fibrodysplasia ossificans progressiva (FOP), where it is genetically driven. Given that in both diseases HO arises via endochondral ossification, the molecular mechanisms behind both diseases have been postulated to be manifestations of similar pathways including those activated by BMP/TGFβ superfamily ligands. A significant step towards understanding the molecular mechanism by which HO arises in FOP was the discovery that FOP causing ACVR1 variants trigger HO in response to activin A, a ligand that does not activate signaling from wild type ACVR1, and that is not inherently osteogenic in wild type settings. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115473DOI Listing

Treatment methods for post-traumatic elbow stiffness caused by heterotopic ossification.

J Shoulder Elbow Surg 2020 Jul;29(7):1380-1386

Department of Orthopaedic Surgery, Columbia University Medical Center/Presbyterian Hospital, New York, NY, USA.

Hypothesis: Heterotopic ossification (HO) is a common complication of surgically treated elbow fractures that can inhibit range of motion and impair quality of life. Although there are many treatment methods for HO, there is a lack of consensus as to the best option. We hypothesized that contracture release combined with Botox injection would lead to improved functional outcome scores when compared with current treatment methods. Read More

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http://dx.doi.org/10.1016/j.jse.2020.02.026DOI Listing

Experimental Model of Zygomatic and Mandibular Defects to Support the Development of Custom Three-Dimensional--Printed Bone Scaffolds.

J Craniofac Surg 2020 Jul-Aug;31(5):1488-1491

Division of Plastic and Reconstructive Surgery, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA.

Introduction: Autologous reconstruction of segmental craniomaxillofacial bone defects is limited by insufficient graft material, donor site morbidity, and need for microsurgery. Reconstruction is challenging due to the complex three-dimensional (3D) structure of craniofacial skeleton. Customized 3D-printed patient-specific biologic scaffolds hold promise for reconstruction of the craniofacial skeleton without donor site morbidity. Read More

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http://dx.doi.org/10.1097/SCS.0000000000006647DOI Listing
June 2020
0.676 Impact Factor

[Bone remodeling after total hip arthroplasty with anatomic medullary locking prosthesis and its long-term effectiveness].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2020 Jun;34(6):689-695

Department of Orthopedics, First Affiliated Hospital, Soochow University, Suzhou Jiangsu, 215006, P.R.China.

Objective: To investigate the femoral bone remodeling and long-term effectiveness of total hip arthroplasty (THA) with anatomic medullary locking (AML) prosthesis.

Methods: The clinical data of 24 cases (26 hips) who were treated with THA with AML prosthesis between November 1997 and January 2003 were retrospectively analyzed. There were 12 males and 12 females with an age of 32-69 years (mean, 53. Read More

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http://dx.doi.org/10.7507/1002-1892.201910033DOI Listing

Comparison of Total Ankle Arthroplasty and Ankle Arthrodesis in End-Stage Hemophilic Arthropathy.

Foot Ankle Int 2020 Jun 15:1071100720929002. Epub 2020 Jun 15.

Department of Orthopaedic Surgery, School of Medicine, Kyung Hee University, Seoul, Korea.

Background: Total ankle arthroplasty (TAA) can result in excellent outcomes in patients with end-stage arthritis, but most patients with end-stage hemophilic ankle arthropathy (ESHAA) still undergo ankle arthrodesis (AA). The purpose of this study was to analyze clinical and radiological results of TAA and AA for ESHAA.

Methods: A total of 29 cases (16 TAAs and 13 AAs) of painful ESHAA were included. Read More

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http://dx.doi.org/10.1177/1071100720929002DOI Listing

Diagnostic Value of Magnetic Resonance Imaging in Fibrodysplasia Ossificans Progressiva.

JBMR Plus 2020 Jun 28;4(6):e10363. Epub 2020 Apr 28.

Department of Internal Medicine section Endocrinology, Amsterdam Bone Center Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences Amsterdam The Netherlands.

Using [F] Sodium Fuoride (NaF) Positron Emission Tomography (PET) it is not only possible to identify the ossifying potency of a flare-up, but also to identify an asymptomatic chronic stage of fibrodysplasia ossificans progressiva (FOP). The purpose of this study was to investigate the diagnostic role of a more widely available imaging modality, Magnetic Resonance Imaging (MRI), which is of special interest for studies in pediatric FOP patients. MRI and [F]NaF PET/CT images at time of inclusion and subsequent follow-up CT scans of 4 patients were analyzed retrospectively. Read More

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http://dx.doi.org/10.1002/jbm4.10363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285757PMC

The Impact of Heterotopic Ossification on Self-Reported Outcomes After Total Hip Arthroplasty Using the Direct Anterior Approach.

J Bone Joint Surg Am 2020 Jun 10. Epub 2020 Jun 10.

Department of Hip and Knee Surgery, Schulthess Clinic, Zürich, Switzerland.

Background: Heterotopic ossification (HO) is a known finding after total hip arthroplasty (THA) that potentially affects clinical outcomes. The incidence of HO is related to various factors, including soft-tissue trauma, postoperative medication, surgical approach, and the surgeon's experience. Because use of the direct anterior approach (DAA) is gaining popularity, we aimed (1) to determine the incidence of HO after DAA-THA and (2) to evaluate the impact of HO on patient-reported outcomes (PROs). Read More

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http://dx.doi.org/10.2106/JBJS.20.00071DOI Listing
June 2020
5.280 Impact Factor

A Model to Improve the Workflow for Radiation Treatments in the Era of Bundled Payments: A Quality Improvement Project Report.

Adv Radiat Oncol 2020 May-Jun;5(3):490-494. Epub 2020 Jan 21.

Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, Mississippi.

The Centers for Medicare and Medicaid Services has proposed alternate payment models to improve the efficiency and decrease the redundancy of health care. Bundled payments or episode-based care is one example. Herein, we report on the successful implementation of a quality improvement project in which changing the clinical workflow for postoperative radiation treatment to the hip to prevent heterotopic ossification improved the efficiency of patient care and decreased cost by eliminating redundant imaging through multidisciplinary participation. Read More

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http://dx.doi.org/10.1016/j.adro.2019.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276685PMC
January 2020

Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification.

Sci Adv 2020 May 29;6(18):eaay9526. Epub 2020 Apr 29.

Dr. Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Heterotopic ossification (HO) in connective tissues like tendons and ligaments severely damages tissue structure. The pathogenesis of HO remains unclear but may involve mTOR. The results presented here indicate that tendon stem/progenitor cells do not undergo osteochondrogenic differentiation when mTOR signaling is inactivated by gene knockout or rapamycin (RAPA) treatment. Read More

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http://dx.doi.org/10.1126/sciadv.aay9526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239699PMC

Severe heterotopic ossification after a shoulder arthroscopy : a rare clinical presentation.

Acta Orthop Belg 2020 Mar;86(1):162-165

Heterotopic ossification is a well-known complication after orthopaedic surgical procedures, with a pre-dilection of the hip and elbow. Heterotopic ossification is a rare complication after shoulder arthroscopy and is rarely clinically significant. We report a case of a 65-year old Caucasian man with a slow and painful recovery after arthroscopic shoulder surgery encompassing rotator cuff repair, biceps tenotomy and acromioplasty, with recurrence of impingement symptoms unresponsive to conservative therapy (physiotherapy and one sub- acromial injection). Read More

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Prolonged dislocation and delay to surgery are associated with higher rates of heterotopic ossification in operatively treated terrible triad injuries.

JSES Int 2020 Jun 27;4(2):238-241. Epub 2020 Apr 27.

Department of Orthopaedic Surgery, Harborview Medical Center, Seattle, WA, USA.

Background: Heterotopic ossification (HO) formation after complex elbow injuries can significantly impact function. Prior studies have reported a 3%-45% incidence of HO following elbow trauma in a heterogeneous cohort of fracture patterns. The purpose of our study was to evaluate the prevalence of and identify risk factors for HO specifically in patients with terrible triad injuries. Read More

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http://dx.doi.org/10.1016/j.jseint.2020.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256879PMC

Microsurgical reconstruction affects the outcome in a translational mouse model for Achilles tendon healing.

J Orthop Translat 2020 Sep 11;24:1-11. Epub 2020 May 11.

Department of Regenerative Musculoskeletal Medicine, Institute of Musculoskeletal Medicine, Westfaelische Wilhelms University Muenster, Muenster, Germany.

Background: Animal models are one of the first steps in translation of basic science findings to clinical practice. For tendon healing research, transgenic mouse models are important to advance therapeutic strategies. However, the small size of the structures complicates surgical approaches, histological assessment, and biomechanical testing. Read More

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http://dx.doi.org/10.1016/j.jot.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260609PMC
September 2020

Endogenous CCN family member WISP-1 inhibits trauma-induced heterotopic ossification.

JCI Insight 2020 Jun 2. Epub 2020 Jun 2.

Department of Pathology, Johns Hopkins University, Baltimore, United States of America.

Heterotopic ossification (HO) is defined as abnormal differentiation of local stromal cells of mesenchymal origin resulting in pathologic cartilage and bone matrix deposition. CCN family members are matricellular proteins that have diverse regulatory functions on cell proliferation and differentiation, including the regulation of chondrogenesis. However, little is known regarding CCN family member expression or function in HO. Read More

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http://dx.doi.org/10.1172/jci.insight.135432DOI Listing

Integrated miRNA-mRNA network revealing the key molecular characteristics of ossification of the posterior longitudinal ligament.

Medicine (Baltimore) 2020 May;99(21):e20268

Guangxi Medical University.

Background: Ossification of the posterior longitudinal ligament (OPLL) refers to an ectopic ossification disease originating from the posterior longitudinal ligament of the spine. Pressing on the spinal cord or nerve roots can cause limb sensory and motor disorders, significantly reducing the patient's quality of life. At present, the pathogenesis of OPLL is still unclear. Read More

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http://dx.doi.org/10.1097/MD.0000000000020268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249941PMC

Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.

ACS Omega 2020 May 12;5(20):11411-11423. Epub 2020 May 12.

Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan.

Fibrodysplasia ossificans progressiva (FOP) is a rare but severe genetic disorder in which acute inflammation elicits progressive heterotopic ossification in the muscles, tendons, and ligaments. Classic FOP is caused by the R206H mutation in ALK2/ACVR1. While several activin receptor-like kinase 2 (ALK2) inhibitors were found to be efficacious in animal models of FOP, most of the ALK2 (R206H) inhibitors lacked sufficient oral bioavailability for efficacy. Read More

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http://dx.doi.org/10.1021/acsomega.9b04245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254505PMC

Medium-term outcome and classification of traumatic anterior hip dislocations.

Hip Int 2020 May 29:1120700020918868. Epub 2020 May 29.

Department of Orthopaedics and Rehabilitation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, USA.

Introduction: Traumatic anterior hip dislocations are subdivided to obturator (inferior) and pubic (superior) dislocations by Epstein's descriptive classification. This rare injury is thought to have favourable clinical outcomes. The incidence of associated femoral head and acetabular injuries has been low in past case series. Read More

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http://dx.doi.org/10.1177/1120700020918868DOI Listing

The Survey of Cells Responsible for Heterotopic Ossification Development in Skeletal Muscles-Human and Mouse Models.

Cells 2020 May 26;9(6). Epub 2020 May 26.

Department of Orthopaedics and Traumatology, Medical University of Warsaw, Lindley 4 St, 02-005 Warsaw, Poland.

Heterotopic ossification (HO) manifests as bone development in the skeletal muscles and surrounding soft tissues. It can be caused by injury, surgery, or may have a genetic background. In each case, its development might differ, and depending on the age, sex, and patient's conditions, it could lead to a more or a less severe outcome. Read More

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http://dx.doi.org/10.3390/cells9061324DOI Listing

Hyperphosphatemic Tumoral Calcinosis: Pathogenesis, Clinical Presentation, and Challenges in Management.

Front Endocrinol (Lausanne) 2020 8;11:293. Epub 2020 May 8.

Skeletal Disorders and Mineral Homeostasis Section, National Institutes of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States.

Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare and disabling disorder of fibroblast growth factor 23 (FGF23) deficiency or resistance. The disorder is manifest by hyperphosphatemia, inappropriately increased tubular reabsorption of phosphate and 1,25-dihydroxy-Vitamin D, and ectopic calcifications. HFTC has been associated with autosomal recessive pathogenic variants in: (1) the gene encoding FGF23; (2) , which encodes a protein responsible for FGF23 glycosylation; and (3) , the gene encoding KLOTHO, a critical co-receptor for FGF23 signaling. Read More

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http://dx.doi.org/10.3389/fendo.2020.00293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225339PMC

[A case of chronic ulcer with ectopic ossification in lower right extremity].

Zhonghua Shao Shang Za Zhi 2020 May;36(5):402-404

Graduate School of Dalian Medical University, Dalian 116044, China, is working at the Department of Burns and Plastic Surgery, Northern Jiangsu People's Hospital, Yangzhou 225001, China.

On January 1st, 2019, one male patient, aged 55 years, with chronic ulcer in right lower extremity was admitted to Northern Jiangsu People's Hospital. After admission, ulcer debridement and vacuum sealing drainage (VSD) surgery was performed in lower right extremity. Two pieces of bone-like tissue was removed from the lateral space between the Achilles tendon and fibula in the right leg, which was confirmed as ossification tissue by histopathological sections after surgery. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190408-00172DOI Listing

A case report of heterotopic ossification caused by high voltage electric injury.

J Burn Care Res 2020 May 26. Epub 2020 May 26.

Department of Burn and Plastic Surgery, Southeast Hospital Affiliated to Xiamen University, Zhangzhou, China.

This case report described the diagnosis and treatment of a patient with ectopic bone injury due to high pressure electric shock. A 24-years-old male patient suffered from burns that covered 50% of total body surface area, including on limbs and torso, after coming into contact with 10 Kv high-voltage electricity. A repeated Meek micrografting technique (MEEK) was applied for wound healing; skin grafts were cut into micrografts and expanded at a ratio of 1:4 to cover large areas after burn trauma. Read More

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http://dx.doi.org/10.1093/jbcr/iraa076DOI Listing

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1.

Orphanet J Rare Dis 2020 May 24;15(1):122. Epub 2020 May 24.

Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan.

Background: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disease characterized by heterotopic ossification (HO) in soft tissues and caused by a mutation of the ACVR1A/ALK2 gene. Activin-A is a key molecule for initiating the process of HO via the activation of mTOR, while rapamycin, an mTOR inhibitor, effectively inhibits the Activin-A-induced HO. However, few reports have verified the effect of rapamycin on FOP in clinical perspectives. Read More

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http://dx.doi.org/10.1186/s13023-020-01406-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245788PMC

Alternative causes of ankle pain in a patient with enthesopathy and X-linked hypophosphataemia.

Lancet 2020 05;395(10237):e97

Department of Rheumatology, Princess Alexandra Hospital, Brisbane, QLD, Australia; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1016/S0140-6736(20)30935-1DOI Listing

Incidence of bone loss after Prestige-LP cervical disc arthroplasty: a single-center retrospective study of 396 cases.

Spine J 2020 May 20. Epub 2020 May 20.

Department of Operating Room, West China Hospital, Sichuan University, No. 37 Guo Xue Rd, Chengdu 610041, China. Electronic address:

Background Context: The development of bone loss (BL) at the operated level after cervical disc arthroplasty (CDA) has not been well recognized. The incidence of BL may be correlated with the prosthesis type. Currently, no study has reported the incidence of BL after CDA with the Prestige-LP disc, and this remains an active area of research. Read More

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http://dx.doi.org/10.1016/j.spinee.2020.05.102DOI Listing

Knee intra-articular extraskeletal aneurysmal bone cyst: a case report and review of literature.

Skeletal Radiol 2020 May 20. Epub 2020 May 20.

Department of Orthopedic surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Aneurysmal bone cyst (ABC) is a benign locally destructive lesion that usually developed in the bone cavity of bones, less commonly on the surface of cortical bones and very rarely develop outside the bone. There are only 35 reports of extraskeletal aneurysmal bone cyst (ESABC) in the English literature. We report a case of a 12-year-old female with no history of trauma who presented with knee pain. Read More

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http://dx.doi.org/10.1007/s00256-020-03464-2DOI Listing