11,269 results match your criteria Heterotopic Ossification


Post-COVID-19 exacerbation of fibrodysplasia ossificans progressiva with multiple flare-ups and extensive heterotopic ossification in a 45-year-old female patient.

Rheumatol Int 2021 Jun 10. Epub 2021 Jun 10.

Department of Rheumatology, Physical and Rehabilitation, Medicine University Hospital Center "Sestre Milosrdnice", Zagreb, Croatia.

Fibrodyplasia ossificans progressiva (FOP) is a rare hereditary disease, which has a variable course characterized by occasional flare-ups of heterotopic ossification (HO) in soft tissues that are followed by swelling, stiffness, pain and warmth. Here, we report for the first time a case of a 45-year-old female patient with known FOP recovering from COVID-19 with disease progression potentially linked with the viral illness. In December 2020 the patient contracted a mild form of COVID-19 infection without need for hospital admission. Read More

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Bone Morphogenetic Protein in Scaphoid Nonunion: A Systematic Review.

J Wrist Surg 2021 Jun 23;10(3):184-189. Epub 2021 Jan 23.

Department of Orthopaedic Surgery, William Beaumont Army Medical Center, El Paso, Texas.

 Scaphoid nonunion can lead to carpal collapse and osteoarthritis, a painfully debilitating problem. Bone morphogenetic protein (BMP) has been successfully implemented to augment bone healing in other circumstances, but its use in scaphoid nonunion has yielded conflicting results.  The purpose of this study is to assess the outcomes and complications of scaphoid nonunion treated surgically with BMP. Read More

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Surgical and Radiological Management of Complicated Uterine Leiomyoma Aided by 3D Models in a Patient with Fibrodysplasia Ossificans Progressiva.

Am J Case Rep 2021 Jun 10;22:e931614. Epub 2021 Jun 10.

Department of Anesthesiology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

BACKGROUND Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of the connective tissue. Over time, patients with FOP experience decreased range of motion in the joints and the formation of a second skeleton, limiting mobility. Patients with FOP are advised to avoid any unwarranted surgery owing to the risk of a heterotopic ossification flare-up. Read More

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Cell-free, quantitative mineralization measurements as a proxy to identify osteoinductive bone graft substitutes.

Biomaterials 2021 May 28;275:120912. Epub 2021 May 28.

RMS Foundation, Bischmattstrasse 12, 2544, Bettlach, Switzerland. Electronic address:

Some synthetic bone graft substitutes (BGS) can trigger ectopic bone formation, which is the hallmark of osteoinduction and the most important prerequisite for the repair of large bone defects. Unfortunately, measuring or predicting BGS osteoinductive potential based on in vitro experiments is currently impossible. A recent study claimed that synthetic BGS can induce bone formation ectopically if they create a local homeostatic imbalance during their in vivo mineralization. Read More

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Skeletal Complications With GNAS Mutation: An Unusual Case With Osteoma Cutis, Gout, and Synovial Chondromatosis in a Patient With Pseudopseudohypoparathyroidism.

AACE Clin Case Rep 2021 May-Jun;7(3):180-183. Epub 2021 Jan 7.

Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California.

Objective: We present a patient with pseudopseudohypoparathyroidism (PPHP) who developed both gout and synovial chondromatosis, in addition to the classical Albright's hereditary osteodystrophy phenotype.

Methods: The patient's clinical course, laboratory data, and imaging are presented.

Results: The patient is a 40-year-old male with no pertinent family history who presented with findings of Albright's hereditary osteodystrophy, including short stature, obesity, rounded face, shortened fourth and fifth digits, and osteoma cutis (heterotopic subcutaneous ossification), which required surgical removal for pain relief. Read More

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January 2021

Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the β-catenin signaling pathway.

J Orthop Translat 2021 Jul 18;29:42-50. Epub 2021 May 18.

Division of Orthopaedic Surgery, Department of Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Background: Tendons are the force transferring tissue that enable joint movement. Excessive mechanical loading is commonly considered as a primary factor causing tendinopathy, however, an increasing body of evidence supports the hypothesis that overloading creates microdamage of collagen fibers resulting in a localized decreased loading on the cell population within the damaged site. Heterotopic ossification is a complication of late stage tendinopathy, which can significantly affect the mechanical properties and homeostasis of the tendon. Read More

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A Rare Case of Extremely Severe Heterotopic Ossification after Primary Total Hip Arthroplasty due to Persistent Mild Periprosthetic Joint Infection.

Case Rep Orthop 2021 22;2021:8849929. Epub 2021 May 22.

Department of Orthopedics, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan.

Periprosthetic joint infection (PJI) caused by coagulase-negative staphylococci (CNS) can be a mild, persisting infection. Although heterotopic ossification (HO) is common following total hip arthroplasty (THA), the etiology of severe HO remains unclear. Herein, we describe a rare case of extremely severe HO after a PJI associated with a infection in a 78-year-old male patient. Read More

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Heterotopic ossification in psammomatous spinal meningioma: a diagnostic controversy.

Int J Clin Exp Pathol 2021 15;14(5):627-632. Epub 2021 May 15.

Division of Neurosurgery, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Jalan Yaacob Latiff, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia.

Heterotopic ossification (HO), a synonym for osseous metaplasia, is a pathological phenomenon, characterized by abnormal bone formation outside the skeletal system observed commonly in various neoplastic and non-neoplastic diseases. HO occurring in meningioma is exceptionally rare. We reportherein an unusual case of spinal meningioma containing numerous calcified psammoma bodies and extensive HO in a 75-year-old woman, who presented with progressive worsening bilateral lower limb weakness and numbness. Read More

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Quercetin Attenuates Trauma-Induced Heterotopic Ossification by Tuning Immune Cell Infiltration and Related Inflammatory Insult.

Front Immunol 2021 20;12:649285. Epub 2021 May 20.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Heterotopic ossification (HO) is one of the most intractable disorders following musculoskeletal injury and is characterized by the ectopic presence of bone tissue in the soft tissue leading to severe loss of function in the extremities. Recent studies have indicated that immune cell infiltration and inflammation are involved in aberrant bone formation. In this study, we found increased monocyte/macrophage and mast cell accumulation during early HO progression. Read More

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The characteristics of the young patients with cervical ossification of the posterior longitudinal ligament of the spine: A multicenter cross-sectional study.

J Orthop Sci 2021 Jun 3. Epub 2021 Jun 3.

Department of Orthopedic Surgery, Keio University, School of Medicine, Tokyo, Japan; Japanese Organization of the Study for Ossification of Spinal Ligament (JOSL), Tokyo, Japan.

Background: Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by heterotopic bone formation in the posterior longitudinal ligament of the spine. Although the patients with OPLL are more common in the 60s and 70s, we know that there are markedly young patients (e.g. Read More

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Osteomyelitis in heterotopic ossification in a patient with congenital gigantism of the leg.

J Bone Jt Infect 2021 16;6(5):141-145. Epub 2021 Apr 16.

Department of Trauma and Orthopaedics, Mater Dei Hospital, Msida, Malta.

This paper presents the first report of osteomyelitis in heterotopic ossification in a patient with macrodystrophia lipomatosa. Careful review of magnetic resonance imaging allowed correct diagnosis and design of a limited surgical excision. Osteomyelitis should be considered in the differential diagnosis of pain and discharge when heterotopic ossification is present. Read More

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Tissue Engineering Through 3D Bioprinting to Recreate and Study Bone Disease.

Biomedicines 2021 May 14;9(5). Epub 2021 May 14.

Department of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83209, USA.

The applications of 3D bioprinting are becoming more commonplace. Since the advent of tissue engineering, bone has received much attention for the ability to engineer normal bone for tissue engraftment or replacement. While there are still debates on what materials comprise the most durable and natural replacement of normal tissue, little attention is given to recreating diseased states within the bone. Read More

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New Strategies in Neurogenic Heterotopic Ossification.

Cureus 2021 Apr 27;13(4):e14709. Epub 2021 Apr 27.

3rd Department of Neurology, National and Kapodistrian University of Athens, Aiginition Hospital, Athens, GRC.

The term neurogenic heterotopic ossification (NHO) is used to describe the pathological bone formation in soft tissues, due to spinal cord or brain injury. Commonly is presented with pain and stiffness of the affected joint. NHO affects the quality of life of these patients, delays their rehabilitation and therefore increases morbidity. Read More

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Ulnar Neuropathy at the Elbow: From Ultrasound Scanning to Treatment.

Front Neurol 2021 14;12:661441. Epub 2021 May 14.

Institute of Anatomy, First Faculty of Medicine, Charles University, Prague, Czechia.

Ulnar neuropathy at the elbow (UNE) is commonly encountered in clinical practice. It results from either static or dynamic compression of the ulnar nerve. While the retroepicondylar groove and its surrounding structures are quite superficial, the use of ultrasound (US) imaging is associated with the following advantages: (1) an excellent spatial resolution allows a detailed morphological assessment of the ulnar nerve and adjacent structures, (2) dynamic imaging represents the gold standard for assessing the ulnar nerve stability in the retroepicondylar groove during flexion/extension, and (3) US guidance bears the capability of increasing the accuracy and safety of injections. Read More

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Clinical-Instrumental Results and Analysis of Functional Activity Restoration in Professional Athletes After Lumbar Total Disk Replacement.

World Neurosurg 2021 May 27. Epub 2021 May 27.

University of Sheffield department Neuroscience, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Objective: To analyze the clinical and biomechanical outcome of professional athletes after lumbar total disk replacement, with a focus on restoration of the functional activity.

Methods: This nonrandomized retrospective single-center study included 11 professional athletes who underwent lumbar disc replacement surgery using the prosthesis M6-L (Spinal Kinetics, Schaffhausen, Switzerland). The average postoperative follow-up was 3. Read More

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Primary Versus Secondary Radiotherapy for Heterotopic Ossification Prevention About the Elbow.

J Orthop Trauma 2021 May 24. Epub 2021 May 24.

University of Miami Miller School of Medicine University of Miami Miller School of Medicine Department of Orthopedic Surgery University of Miami Miller School of Medicine Department of Radiation Oncology.

Objectives: To examine the efficacy and safety of radiotherapy for the prevention of heterotopic ossification (HO) about the elbow.

Design: Retrospective chart review.

Setting: Level 1 Trauma Center. Read More

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Primary outcomes of a femoral neck-preserving stem: a multicentre clinical-radiological analysis at 5-year follow-up.

Eur J Orthop Surg Traumatol 2021 May 26. Epub 2021 May 26.

Orthopedic and Traumatology Service , Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Purpose: The aim of this prospective study was to evaluate the clinical-radiological outcomes of the Alteon Neck Preserving Stem (ANPS) (Exactech, Gainesville, FL, USA) implanted in four different centres by five senior hip surgeons with a minimum of 5 years of follow-up.

Material And Method: We conducted a multicentre prospective study that analysed 155 consecutive total hip replacements during 2014. We performed clinical-radiological analysis measuring Harris Hip Score (HHS), subjective satisfaction evaluation, radiolucencies, position of components, limb length discrepancy, heterotopic ossification, medical and surgical complications and a survival analysis at 5 years follow-up. Read More

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Modified Stoppa Approach for the Treatment of Complex Acetabular Fractures.

Orthopedics 2021 May-Jun;44(3):e353-e358. Epub 2021 May 1.

Complex acetabular fractures are due to high-energy trauma in most cases. The operative management of these types of fractures is often difficult and technically challenging. Almost all of these types of fractures are treated through extensile approaches, and a variety of them have been described. Read More

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Off-on-off-on use of imatinib in three children with fibrodysplasia ossificans progressiva.

Bone 2021 May 19;150:116016. Epub 2021 May 19.

The Department of Medicine, The Mayo Clinic, Rochester, MN 55905, United States of America. Electronic address:

The compassionate use of available medications with unproven efficacy is often in conflict with their clinical evaluation in placebo-controlled clinical trials. For ultra-rare diseases where no approved treatments exist, such as fibrodysplasia ossificans progressiva (FOP), routine clinical trial enrollment for available medications may be difficult to achieve. Therefore adaptive methods of evaluation are often desirable. Read More

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[Application of annular ligament reposition and repair via Henry's approach for Monteggia fracture in children].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 May;35(5):562-566

Department of Orthopedics, Yantaishan Hospital, Yantai Shandong, 264000, P.R.China.

Objective: To explore the effectiveness of annular ligament reposition and repair via Henry's approach for Monteggia fracture in children.

Methods: A clinical data of 21 children with Monteggia fractures was retrospectively analysed, who underwent open reduction of the radial head and annular ligament reposition and repair via Henry's approach between May 2015 and July 2019. There were 11 boys and 10 girls with an average age of 8 years and 1 month (range, 4 years and 5 months to 14 years and 4 months). Read More

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Comparing Thoracic Extensive Laminoplasty (TELP) and Laminectomy in Treating Severe Thoracic Ligamentum Flavum Ossification: A Proposed Novel Technique and Case-Control Study.

Biomed Res Int 2021 20;2021:8410317. Epub 2021 Apr 20.

Department of Orthopedics, Changzheng Hospital, Second Affiliated Hospital of Second Military Medical University, 415 Fengyang Road, Shanghai, China 200003.

Objective: (1) To propose a novel technique named thoracic extensive laminoplasty (TELP) in curing severe thoracic ligamentum flavum ossification (STOLF) and (2) to compare outcomes between TELP and laminectomy in curing STOLF.

Methods: Cases with fused or tuberous STOLF (Sato classification) treated from Jan 2015 to Jan 2017 were reviewed and divided into the TELP group (G1) and laminectomy group (G2) according to their surgical management. Data on demographics, complications, pre- and postoperative symptoms, residual spinal canal area (RSCA-1), residual spinal cord area (RSCA-2), modified Japanese Orthopedic Association score (mJOA), and health-related quality of life (HRQOL, based on the SF-36) were collected. Read More

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Analysis of Factors Affecting Return to Work After Surgical Treatment in Patients with AO Type C Distal Humerus Fractures.

Indian J Orthop 2021 Jun 19;55(3):680-687. Epub 2020 Sep 19.

Orthopaedic and Traumatology Department, Orthopaedic Surgeon Tepecik Training and Research Hospital, Yenisehir, 35110 Izmir, Turkey.

Background: The purpose of this study is to evaluate the functional results of distal humerus fractures which were treated by open reduction and fixation with pre-contoured angular stable plates in young patients, and investigate whether the patients could return to their pre-injury work and patients' financial conditions while they were not working.

Materials And Methods: The data of 48 patients, ages between 18 and 55 years, working in a job and having AO/OTA type C distal humerus fracture were retrospectively evaluated. Mayo Elbow Performance Score (MEPS) was used to determine functional results. Read More

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Mid-term follow-up of superior pubic ramus osteotomy in locked symphysis pubis with urethral injury: A case report.

Chin J Traumatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Orthopaedics, Institute of Medical Sciences and Sum Hospital, Bhubaneswar, 751003, India. Electronic address:

A locked pubic ramus body is an unusual variant of lateral compression injury. Till date, there have been only 25 cases reported in the published literature. We herein described a case where the right pubic ramus was entrapped within the opposite obturator foramen with an overlap of greater than 4 cm, with associated urethral injury. Read More

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Single-Level Cervical Arthroplasty with Prodisc-C Vivo Artificial Disc: Five-Year Follow-Up Results from One Center.

Spine (Phila Pa 1976) 2021 May 13. Epub 2021 May 13.

Peking University Third Hospital, Department of Orthopedics, Beijing Key Laboratory of Spinal Disease Research, Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing.

Study Design: Retrospective study.

Objective: The aim of this study was to evaluate the long-term clinical and radiographic outcomes of cervical arthroplasty using the ProDisc-C Vivo prosthesis.

Summary Of Background Data: Previous reports have shown that cervical arthroplasty with ProDisc-C artificial disc has acceptable clinical outcomes at 5-year and 10-year follow-ups. Read More

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Treatment of grossly dislocated supracondylar humerus fractures after failed closed reduction: a retrospective analysis of different surgical approaches.

Arch Orthop Trauma Surg 2021 May 13. Epub 2021 May 13.

Department of Trauma and Orthopedic Surgery, BG Unfallklinik Frankfurt Am Main, Friedberger Landstr. 430, 60389, Frankfurt am Main, Germany.

Introduction: The supracondylar humerus fracture (SCHF) is one of the most common pediatric injuries. Highly displaced fractures can be very challenging. If closed reduction fails, the therapy algorithm remains controversial. Read More

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Intra-articular silencing of periostin via nanoparticle-based siRNA ameliorates post-traumatic osteoarthritis in mice.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Department of Orthopaedic Surgery, Musculoskeletal Research Center, Washington University, School of Medicine, St. Louis, MO, United States.

Objective: Recent evidence delineates an emerging role of Periostin (Postn) in osteoarthritis (OA) as its expression subsequent to knee injury is detrimental to the articular cartilage. We hypothesize that intra-articular knockdown of Postn in a murine model of post-traumatic OA would ameliorate OA.

Methods: Post-traumatic OA was induced in 10-week-old male C57BL/6J mice (n=24) by destabilization of the medial meniscus (DMM) and analyzed 8-week post-surgery. Read More

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Excision of Heterotopic Ossification around the Hip: Arthroscopic and Open Techniques.

Arthrosc Tech 2021 Apr 22;10(4):e1179-e1186. Epub 2021 Apr 22.

Department of Orthopedic Surgery, University of Wisconsin-Madison, Madison, Wisconsin, U.S.A.

Heterotopic ossification (HO) can occur as a complication of various pathologies affecting the hip including trauma, tendon avulsions, chronic injury, spinal cord injury, and soft-tissue disruption caused by surgery. When HO is present alongside intra-articular hip pathology such as femoroacetabular impingement syndrome (FAIS) or labral pathology, consideration should be made to combine the surgical excision of the HO with the FAIS decompression or labral repair if the location and size of the HO is appropriate for arthroscopic excision. Often times, the HO is located in such a position that any central compartment work can be completed before turning to the HO excision. Read More

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Nonclassic fibrodysplasia ossificans progressiva: A child from Angola with an ACVR1 variant.

Am J Med Genet A 2021 May 11. Epub 2021 May 11.

Departments of Orthopaedic Surgery, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Little is known about FOP in Africa and few cases of nonclassic fibrodysplasia ossificans progressiva (FOP) have been reported on the continent. Here we report a three-year-old girl from Angola with a nonclassic FOP clinical presentation that is characterized by complex malformations of the toes and fingers, reduction defects of the digits, absence of nails, progressive heterotopic ossification, and a confirmed heterozygous ACVR1 variant at c.983G > A. Read More

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Arthrofibrosis following primary total hip arthroplasty: a distinct clinical entity.

Arch Orthop Trauma Surg 2021 May 9. Epub 2021 May 9.

Department of Orthopaedic Surgery, Helios ENDO-Klinik Hamburg, Holstenstr. 2, 22767, Hamburg, Germany.

Introduction: Arthrofibrosis is a relatively frequent complication after total knee arthroplasty. Although stiffness after total hip arthroplasty (THA), because of formation of heterotopic ossification or other causes, is not uncommon, to the authors' best knowledge, arthrofibrosis after THA has not been described. The aim of this study is to describe the arthrofibrosis of the hip after primary THA using an established clinical and histological classification of arthrofibrosis. Read More

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Intravenous tranexamic acid reduce postoperative drainage and pain after open elbow arthrolysis: A randomized controlled trial.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P. R. China. Electronic address:

Background: Open elbow arthrolysis (OEA), which has become an established treatment for post-traumatic elbow stiffness (PTES), requires complete release of contracture tissue and wide excision of ectopic bone, which results in extensive bleeding. The aim of the present study is to evaluate the efficacy of intravenous tranexamic acid (TXA) on postoperative drainage, calculated blood loss and early clinical outcomes in patients undergoing OEA.

Methods: A double-blind, randomized, placebo-controlled trial including 96 patients undergoing OEA was undertaken. Read More

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