11,830 results match your criteria Heterotopic Ossification


Surgical Resection Combined with Adjuvant Radiotherapy and Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Heterotopic Ossification Following Total Hip Arthroplasty.

Acta Med Port 2022 Jun 24. Epub 2022 Jun 24.

Orthopaedics Department. Hospital José Joaquim Fernandes. Unidade Local de Saúde do Baixo Alentejo. Beja. Portugal.

Heterotopic ossification (HO) is a well-known complication following total hip arthroplasty (THA), with an average incidence of 30%. Patients are classified according to Brooker's staging system. In advanced stages (III and IV), HO may limit hip motion and cause intolerable pain. Read More

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Case Report: Unusual Heterotopic Ossification of the Hindfoot.

Front Surg 2022 7;9:917560. Epub 2022 Jun 7.

Clinical Orthopedics, Department of Clinical and Molecular Science, School of Medicine, Università Politecnica delle Marche, Ancona, Italy.

Heterotopic ossification (HO) is a pathologic condition in which aberrant lamellar bone deposits in soft tissues, outside of the normal skeleton. Pathogenesis is still unclear, but different risk factors are known. Here we report a case of a 14 year-old girl presenting with pain in the medial calcaneal region and evidence of a rapidly growing, firm and solid neoformation. Read More

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Galunisertib attenuates progression of trauma-induced heterotopic ossification via blockage of Smad2/3 signaling in mice.

Eur J Pharmacol 2022 Jun 20;928:175109. Epub 2022 Jun 20.

Department of Hand Surgery, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214062, China. Electronic address:

Heterotopic ossification (HO) is the formation of bony tissues in the extraskeletal system. To date, no effective therapy has been developed for the treatment of HO, although increasing evidences have shown that inhibition of TGF-β signaling has potential as a new therapeutic approach for attenuating HO progression. Results from previous clinical trials have demonstrated that patients with malignant tumors exhibit excellent tolerability to Galunisertib, a TGF-β receptor I kinase inhibitor. Read More

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Impact of Indication for Revision THA on Resource Utilization.

J Arthroplasty 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopedic Surgery, NYU Langone Health, New York, New York. Electronic address:

Introduction: Demographic variables play an important role in outcomes following revision total hip arthroplasty (rTHA). Surgical and in-patient variables as well as outcomes vary between indications for rTHA. The purpose of this study was to investigate the impact of the indication for the rTHA on costs and postoperative outcomes. Read More

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Terrible triad injury of the elbow: A PROCESS-compliant surgical case series from Eastern Morocco.

Ann Med Surg (Lond) 2022 Jun 4;78:103914. Epub 2022 Jun 4.

Department of Traumatology and Orthopedics, Mohammed VI University Hospital, Oujda, Morocco.

Introduction: The terrible triad of the elbow (TTE) is a lesion associating a dislocation of the elbow, a fracture of the radial head, and a fracture of the coronoid process, with a high potential of complication. The treatment is based on the restoration of bone lesions and external capsular ligament repair. The systematic repair of the medial collateral ligament (MCL) is still debated in the literature. Read More

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Double Plating in Type C Distal Humerus Fractures: Current Treatment Options and Factors that Affect the Outcome.

Strategies Trauma Limb Reconstr 2022 Jan-Apr;17(1):7-13

Department of Orthopaedic Surgery and Musculoskeletal Trauma, University Hospital of Larissa, Larissa, Greece.

Purpose: This is a retrospective cohort study of type C distal humeral fractures (AO classification system) aimed at evaluating the effectiveness of current operative treatment options.

Materials And Methods: Thirty-seven patients with type C distal humeral fractures, treated operatively from January 2002 to September 2016, were retrospectively studied. Thirty-two were eligible for inclusion. Read More

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Are there really specific risk factors for heterotopic ossifications? A case report of 'non-risk factor' after total hip replacement.

J Int Med Res 2022 Jun;50(6):3000605221095225

Department of Adult Orthopaedics, District Hospital of Orthopaedics and Trauma Surgery, Piekary Śląskie, Poland.

Femoral neck fractures are one of the most common fractures in the elderly population. Due to frequent complications of the fixation of these fractures, patients are more and more often eligible for hip replacement surgery. One of the most frequently mentioned postoperative complication is the formation of heterotopic ossification. Read More

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Deciphering Obesity-Related Gene Clusters Unearths SOCS3 Immune Infiltrates and 5mC/m6A Modifiers in Ossification of Ligamentum Flavum Pathogenesis.

Front Endocrinol (Lausanne) 2022 30;13:861567. Epub 2022 May 30.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China.

Background: Ossification of ligamentum flavum (OLF) is an insidious and debilitating heterotopic ossifying disease with etiological heterogeneity and undefined pathogenesis. Obese individuals predispose to OLF, whereas the underlying connections between obesity phenotype and OLF pathomechanism are not fully understood. Therefore, this study aims to explore distinct obesity-related genes and their functional signatures in OLF. Read More

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Successful Total Knee Arthroplasty in a Patient With Contralateral Ankylosis Due to Severe Heterotopic Ossification.

Cureus 2022 May 12;14(5):e24941. Epub 2022 May 12.

Orthopaedic Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, USA.

A 63-year-old woman with ankylosis of the left knee due to severe heterotopic ossification (HO) following total knee arthroplasty (TKA) underwent right TKA with preoperative radiation and postoperative chemical prophylaxis for HO. At the one-year follow-up, the patient had no evidence of HO in the right knee. To our knowledge, there are no reports of successful arthroplasty in patients with a history of ankylosis due to severe HO. Read More

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The novel infra-pectineal buttress plates used for internal fixation of elderly quadrilateral surface involved acetabular fractures.

Orthop Surg 2022 Jun 15. Epub 2022 Jun 15.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Objectives: In geriatric acetabular fractures, the quadrilateral surface (QLS) was frequently involved in acetabular fracture patterns and accompanied by medial displacement. It was important to buttress the medial displaced QLS and reconstruct the congruity of the affected acetabulum. To evaluate the clinical effectiveness of the novel infra-pectineal quadrilateral surface buttress plates for the treatment of geriatric acetabular fractures. Read More

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Twists in the fibrodysplasia ossificans progressiva story challenge and expand our understanding of BMP biology.

J Clin Invest 2022 Jun;132(12)

Fibrodysplasia ossificans progressiva (FOP) is an ultrarare, debilitating disease in which heterotopic bone is formed in certain soft tissues. A gain-of-function variant in the cytoplasmic domain of the activin A receptor type I (ACVR1) exists in all patients with FOP. Strikingly, these FOP-causing variants imbue a neofunction to ACVR1 - the ability to recognize activin A as an agonist with bone morphogenic protein-like signaling that leads to heterotopic ossification (HO). Read More

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A comprehensive update on the pharmacological management of heterotopic ossification following hip arthroplasty: a level I evidenced based expert opinion.

Expert Opin Pharmacother 2022 Jun 13:1-9. Epub 2022 Jun 13.

Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi (SA), Italy.

Introduction: Heterotopic ossification (HO) of the hip joint may happen accompanying skeletal muscle trauma or surgical procedures. The pharmacological prophylaxis of heterotopic ossification (HO) following total hip arthroplasty (THA) is debated.

Areas Covered: This expert opinion aims to systematically investigate the efficacy of current pharmacological options as prophylaxis for HO following THA. Read More

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Association between periodontitis and ossification of the posterior longitudinal ligament: a case report.

J Med Case Rep 2022 Jun 13;16(1):236. Epub 2022 Jun 13.

Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Aomori, 036-8562, Japan.

Introduction: Ossification of the posterior longitudinal ligament in the spinal ligament compresses the spinal cord, causing various spinal nerve diseases. The ligament tissue is an important connective tissue in the joints, teeth, and spine, which, when torn and damaged, reduces the range of movement.

Case Presentation: We report the treatment of periapical periodontitis and tooth preservation in a 41-year-old Japanese woman previously diagnosed with ossification of the posterior longitudinal ligament. Read More

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Modified Graft Loop Technique Augmented With Nonabsorbable Suture Tape for Chronic Elbow Dislocation.

Tech Hand Up Extrem Surg 2022 Apr 5. Epub 2022 Apr 5.

Department of First Orthopaedic, Georgios Papanikolaou Hospital, Aristotle University, Thessaloniki.

The task of achieving a good clinical outcome on patients with chronic elbow dislocation is arduous. Any stabilization method used should be robust enough in order to allow for early elbow motion. Immobilization of the elbow for a prolonged time period may lead to stiffness and heterotopic ossification. Read More

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Styloid Process Length Variations: An Osteological Study.

Acta Med Acad 2022 Apr;51(1):46-51

The Public Institution Health Center of Sarajevo Canton, Bosnia and Herzegovina.

Objective: The objective of this study was to study the morphometry of the styloid process of the temporal bone and the prevalence of an elongated styloid process in relation to side and gender.

Material And Method: The present study included 200 human skulls which were procured from the rich osteological collections of the Department of Anatomy, Faculty of Medicine, University of Sarajevo. The styloid process was observed macroscopically on both sides of all the skulls and elongations, if any, were noted. Read More

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Rotating Hinge Revision Total Knee Arthroplasty for Severe Arthrofibrosis.

JBJS Essent Surg Tech 2021 Oct-Dec;11(4). Epub 2021 Dec 22.

Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY.

Stiffness following total knee arthroplasty is a challenging complication for both the patient and surgeon, with an incidence that ranges from 1% to 13%. There are several correctable mechanical causes for stiffness including malposition, malalignment, overstuffing, aseptic loosening, patella baja, and heterotopic ossification. Idiopathic stiffness is often termed arthrofibrosis and is more difficult to treat. Read More

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December 2021

Is gender a factor affecting long-term heterotopic ossification incidence after single-level cervical disc arthroplasty?

World Neurosurg 2022 Jun 7. Epub 2022 Jun 7.

- Neurosurgery Unit, ASST Fatebenefratelli Sacco, Milan, Italy.

Background: Cervical disc diseases have been treated by means of cervical disc arthroplasty (CDA). Nevertheless, some patients will experience a mobility failure in their cervical prostheses over time because of heterotopic ossification (HO). Aim of this study is to investigate the role of gender in long-term outcomes after CDA. Read More

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Long-term dental outcomes in patients with fibrodysplasia ossificans progressiva: a report of three cases of tooth extraction.

Quintessence Int 2022 Jun 8;0(0):2-10. Epub 2022 Jun 8.

Fibrodysplasia ossificans progressiva (FOP) is an extremely rare autosomal dominant disorder characterized by congenital skeletal malformation and progressive heterotopic ossification. In the oral and maxillofacial region, deformity of the temporomandibular joint is a common feature of FOP, as well as restricted mouth opening derived from heterotopic ossification in the masticatory muscles. Since surgical procedures are generally not recommended because of the risk of flare-ups and increased heterotopic ossification, reports of tooth extractions and their outcomes in patients with FOP are limited. Read More

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Oblique-ilioischial plate technique: a novel method for acetabular fractures involving low posterior column.

BMC Musculoskelet Disord 2022 Jun 6;23(1):540. Epub 2022 Jun 6.

Department of Orthopaedic and Trauma, The Second People's Hospital of Yunnan Province, Kunming, China.

Background: Complex acetabular fractures involving the anterior and posterior columns are an intractable clinical challenge. The study investigated the safety and efficacy of oblique-ilioischial plate technique for acetabular fractures involving low posterior column.

Methods: A retrospective analysis of 18 patients operated with the oblique-ilioischial plate technique by the modified Stoppa approach (or combined with iliac fossa approach) between August 2016 and July 2021 for low posterior column acetabular fractures was conducted. Read More

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Heterotopic Mesenteric Ossification With Trilineage Hematopoiesis.

Cureus 2022 Apr 30;14(4):e24620. Epub 2022 Apr 30.

Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, USA.

Heterotopic ossification (HO) histologically refers to extraskeletal bone formation in non-ossifying tissues, most commonly noted in the extremities, buttocks, abdominal wall, and hip joints. HO developing in the mesentery (heterotopic mesenteric ossification, HMO) is very rare, with fewer than 100 cases reported in the literature. It usually occurs in adult male patients with a history of repeated abdominal trauma. Read More

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Cochlear implantation for post-meningitis deafness with cochlear ossification: diagnosis and surgical strategy.

Acta Otolaryngol 2022 May 2;142(5):369-374. Epub 2022 Jun 2.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: Cochlear ossification (CO) after meningitis can cause profound sensorineural hearing loss (SNHL). Cochlear implantation (CI) is the ideal treatment strategy for CO.

Aims: To explore the strategy for CI in patients with CO after meningitis. Read More

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Protocol paper: a multi-center, double-blinded, randomized, 6-month, placebo-controlled study followed by 12-month open label extension to evaluate the safety and efficacy of Saracatinib in Fibrodysplasia Ossificans Progressiva (STOPFOP).

BMC Musculoskelet Disord 2022 Jun 1;23(1):519. Epub 2022 Jun 1.

Department of Internal Medicine Section Endocrinology, Amsterdam UMC location Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081HV, Amsterdam, The Netherlands.

Background: Fibrodysplasia Ossificans Progressiva (FOP) is a genetic, progressive and devastating disease characterized by severe heterotopic ossification (HO), loss of mobility and early death. There are no FDA approved medications. The STOPFOP team identified AZD0530 (saracatinib) as a potent inhibitor of the ALK2/ACVR1-kinase which is the causative gene for this rare bone disease. Read More

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A Network Pharmacology Study: Reveal the Mechanisms of Palovarotene Against Heterotopic Ossification.

Front Med (Lausanne) 2022 13;9:897392. Epub 2022 May 13.

Department of Orthopedics, Shanghai Fenxian District Central Hospital/Anhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai, China.

Heterotopic ossification (HO) occurs when bone forms within non-ossifying tissues, such as in muscle. Palovarotene, an activator of retinoic acid receptor γ (RAR-γ), has been shown to inhibit the formation of ectopic bone in HO model mice, but its specific mechanism of action remains unclear. This study will explore the target and molecular mechanism of Palovarotene's action on HO by network pharmacology study. Read More

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Massive Cervical Heterotopic Ossification and Extra-Articular Temporomandibular Joint Ankylosis.

J Pediatr 2022 May 26. Epub 2022 May 26.

Pediatric Rheumatology Unit, Department of Pediatrics, Meir Medical Center, Kfar Saba, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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Reoperations and Radiographic Outcomes of Monteggia Variant Facture Repair Through a Trans-Olecranon Approach.

Bull Hosp Jt Dis (2013) 2022 Jun;80(2):180-185

Background: Adult Monteggia fracture variants are rare but potentially devastating injuries to the elbow generally requiring surgical treatment. Monteggia injuries with co- existing fractures of the radial head and coronoid present a surgical challenge due to the need to adequately expose all components of the injury for internal fixation or arthroplasty. In this study, we evaluated the clinical outcomes following surgical treatment of adult Monteggia fracture variants in which a coexisting radial head or coronoid fracture was ad- dressed through a single extensile posterior trans-olecranon approach. Read More

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Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma.

Bone Res 2022 Jun 1;10(1):43. Epub 2022 Jun 1.

Department of Pathology, Johns Hopkins University, Baltimore, MD, 21205, USA.

The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of interest. Here, we sought to define the regulatory relationship of peripheral nerves on vasculature in a severe extremity trauma model in mice, which results in aberrant cell fate and heterotopic ossification (HO). First, a high spatial degree of neurovascular congruency was observed to exist within extremity injury associated heterotopic ossification. Read More

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Palovarotene inhibits the NF-κB signalling pathway to prevent heterotopic ossification.

Clin Exp Pharmacol Physiol 2022 May 31. Epub 2022 May 31.

Department of Orthopedics, Anhui University of Science and Technology Affiliated Fengxian Hospital, Shanghai, China.

Heterotopic ossification (HO) is a common disease characterized by pain, dysfunction and calcification. The mechanisms underlying HO have not been completely elucidated. Palovarotene, a retinoic acid receptor γ agonist, significantly inhibits the formation of HO in vivo. Read More

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Elbow hemiarthroplasty with a 3D-printed megaprosthesis for defects of the distal humerus or proximal ulna after tumour resection : a preliminary report.

Bone Joint J 2022 Jun;104-B(6):747-757

Musculoskeletal Tumor Center, Peking University People's Hospital, Beijing, China.

Aims: The aim of this study was to investigate the feasibility of application of a 3D-printed megaprosthesis with hemiarthroplasty design for defects of the distal humerus or proximal ulna following tumour resection.

Methods: From June 2018 to January 2020, 13 patients with aggressive or malignant tumours involving the distal humerus (n = 8) or proximal ulna (n = 5) were treated by en bloc resection and reconstruction with a 3D-printed megaprosthesis with hemiarthroplasty, designed in our centre. In this paper, we summarize the baseline and operative data, oncological outcome, complication profiles, and functional status of these patients. Read More

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Over-expression of wild-type ACVR1 in fibrodysplasia ossificans progressiva mice rescues perinatal lethality and inhibits heterotopic ossification.

J Bone Miner Res 2022 May 30. Epub 2022 May 30.

Department of Molecular and Cell Biology, University of Connecticut Stem Cell Institute, University of Connecticut, Storrs, CT, USA.

Fibrodysplasia ossificans progressiva (FOP) is a devastating disease of progressive heterotopic bone formation for which effective treatments are currently unavailable. FOP is caused by dominant gain-of-function mutations in the receptor ACVR1 (also known as ALK2), which render the receptor inappropriately responsive to activin ligands. In previous studies, we developed a genetic mouse model of FOP that recapitulates most clinical aspects of the disease. Read More

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Are There Identifiable Risk Factors Associated With Heterotopic Ossification of the Temporomandibular Joint?

J Oral Maxillofac Surg 2022 May 2. Epub 2022 May 2.

Visiting Oral and Maxillofacial Surgeon, Division of Oral and Maxillofacial Surgery, Department of Surgery, Massachusetts General Hospital, Professor Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, MA. Electronic address:

Purpose: Heterotopic ossification (HO) is defined as "bone where it does not belong" and as the abnormal presence of calcifications within soft tissues or joints. The purpose of this study was to answer the following clinical question: Are there identifiable risk factors associated with HO in and around the temporomandibular joint (TMJ)?

Methods: We designed a retrospective review of patients seen at the Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, between January 1985 and December 2019 and diagnosed with HO involving the TMJ. Variables studied included demographic factors, medical history including hereditary conditions, and specific TMJ history including past interventions. Read More

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