10,202 results match your criteria Heterotopic Ossification


An anterior neurovascular interval approach to coronal shear fractures of the distal humerus: a prospective clinical study with short- to mid-term follow-up.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):355-360. Epub 2019 Apr 11.

Emergency Center of Trauma, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

Object: To explore the treatment effect of the anterior medial neurovascular interval approach to coronal shear fractures of the distal humerus.

Methods: This prospective study included two female patients who were 30-64 years old, with a mean age of 47 years. Fractures were caused by falling from a bicycle. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1806-9282.65.3.355DOI Listing
March 2019
1 Read

Is prophylaxis for heterotopic ossification with radiation therapy after THR associated with early loosening or carcinogenesis?

Hip Int 2019 Apr 16:1120700019842724. Epub 2019 Apr 16.

3 Laboratory of Orthopedics and Biomechanics, University of Ioannina, School of Medicine, Ioannina, Greece.

Introduction: Heterotopic ossification may develop after major hip surgeries, thus preventive strategies including radiation therapy and non steroid anti-inflammatory drugs are commonly employed. There are certain concerns regarding the effects of radiation therapy on implant loosening and carcinogenesis. Our study aims to evaluate whether radiation therapy results in implant loosening or radiation-induced tumours in the long term. Read More

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http://dx.doi.org/10.1177/1120700019842724DOI Listing

BMP and mTOR signaling in heterotopic ossification: Does their crosstalk provide therapeutic opportunities?

J Cell Biochem 2019 Apr 15. Epub 2019 Apr 15.

Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology and Department of Pathophysiology, School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi, China.

Heterotopic ossification (HO) refers to the pathological formation of ectopic bone in soft tissues, it occurs following severe trauma or in patients with a rare genetic disorder known as fibrodysplasia ossificans progressiva. The pathological process of HO formation is a two-step mechanism: inflammation and destruction of connective tissues, followed by bone formation. The latter is further subdivided into three stages: fibroproliferation/angiogenesis, chondrogenesis, and osteogenesis. Read More

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http://dx.doi.org/10.1002/jcb.28710DOI Listing

Conversion to total hip arthroplasty in posttraumatic arthritis: short-term clinical outcomes.

Orthop Res Rev 2019 4;11:41-46. Epub 2019 Feb 4.

Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran,

Background: Fractures of the acetabulum are challenging and very difficult to treat, and even after fixation, they can lead to posttraumatic arthritis. Total hip arthroplasty (THA) has been the most common surgery performed for the complications of posttraumatic arthritis in this group of patients.

Aim: In this article, it is aimed to assess the functional results and complications of the conversion to THA for posttraumatic arthritis after acetabular fracture. Read More

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http://dx.doi.org/10.2147/ORR.S184590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442317PMC
February 2019

[Mid-term effectiveness of surgical hip dislocation for femoroacetabular impingement].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):451-454

Department of Orthopedics, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiaotong University, Shanghai, 200233, P.R.China.

Objective: To assess the mid-term effecitveness of femoroacetabular impingement (FAI) treated by surgical hip dislocation.

Methods: Between April 2014 and August 2015, 15 patients (16 hips) with FAI were enrolled in the study and treated with surgical hip dislocation. There were 12 males and 3 females with an average age of 36. Read More

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http://dx.doi.org/10.7507/1002-1892.201811083DOI Listing

[Effectiveness evaluation of Prodisc-C prosthesis for more than 10 years follow-up after total cervical disc replacement].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):393-402

Department of Spinal Surgery, Peking University People's Hospital, Beijing, 100044,

Objective: To evaluate long-term radiographic and clinical effectiveness of total cervical disc replacement (TDR) with Prodisc-C prosthesis at a minimum of 10 years follow-up.

Methods: The clinical data of 118 patients with cervical disc degeneration disease (CDDD) treated with TDR by using Prodisc-C prosthesis between December 2005 and April 2008 were retrospectively analyzed. There were 66 males and 52 females, with the age of 25-62 years (mean, 46. Read More

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http://dx.doi.org/10.7507/1002-1892.201810109DOI Listing

Effects of BMP-2 on neovascularization during large bone defect regeneration.

Tissue Eng Part A 2019 Apr 11. Epub 2019 Apr 11.

University of Pennsylvania, Orthopaedic Surgery, Bioengineering , 376A Stemmler Hall, UNIVERSITY OF PENNSYLVANIA , UNIVERSITY OF PENNSYLVANIA , Philadelphia, Pennsylvania, United States , 19104 ;

Insufficient blood vessel supply is a primary limiting factor for regenerative approaches to large bone defect repair. Recombinant BMP-2 delivery induces robust bone formation and has been observed to enhance neovascularization, but whether the angiogenic effects of BMP-2 are due to direct endothelial cell stimulation or to indirect paracrine signaling remains unclear. Here, we evaluated the effects of BMP-2 delivery on vascularized bone regeneration and tested whether BMP-2 induces neovascularization directly or indirectly. Read More

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http://dx.doi.org/10.1089/ten.TEA.2018.0326DOI Listing
April 2019
1 Read

MiR-19b-3p regulates osteogenic differentiation of PDGFRα muscle cells by specifically targeting PTEN.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

Department of Orthopaedics and National Clinical Research Center for Geriatric Disorders, , Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.

Heterotopic ossification (HO) is a common disturbing complication of intra-articular fractures. Its prevention and treatment are still difficult as its pathogenesis is unclear. It was reported that PDGFRα muscle cells in skeletal muscle may participate in the formation of HO, however the specific mechanism is still unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11133
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http://dx.doi.org/10.1002/cbin.11133DOI Listing
April 2019
4 Reads

Critical Illness Polyneuropathy (CIP): a multicenter study on functional outcome.

G Ital Med Lav Ergon 2019 Mar;41(1):58-64

Department of High Technology Rehabilitation and Pain Rehabilitation Unit, Habilita Care and Research Hospitals, Zingonia di Ciserano (BG), Italy.

Objectives: To describe the functional recovery of consecutive inpatients with Critical Illness Polyneuropathy (CIP) at the time-point of the discharge from rehabilitation units according to Barthel Index scores. To examine whether age, gender, pre-ICU admission diagnosis, tracheostomy performance, heterotopic ossification development and duration of neuro-rehabilitation treatment are among the prognostic factors that can predict the functional outcome in studied patients.

Methods: A retrospective observational clinical study from January 2010 to December 2014 in three rehabilitation units in Greece. Read More

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March 2019
4 Reads

A systematic review and meta-analysis of naproxen for prevention heterotopic ossification after hip surgery.

Medicine (Baltimore) 2019 Apr;98(14):e14607

Department of Pediatric Orthopaedic Surgery, Qi1u Hospital, Shandong University, People's Republic of China.

Background: The aim of this study was to assess the efficacy of naproxen in preventing heterotopic ossification (HO) after hip surgery (total hip arthroplasty [THA] and hip arthroscopy).

Methods: Using databases (PubMed, EMBASE, and Web of Science), we conducted an electronic, systematic search of randomized controlled trials (RCTs) comparing naproxen versus placebo on HO after hip surgery. The risk ratio (RR) of the dichotomous data, weighted mean difference (WMD) of continuous data, and 95% confidence intervals (CIs) were calculated to assess the effects of naproxen in patients with hip surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000014607DOI Listing
April 2019
2 Reads

Traumatic Anteromedial Radial Head Dislocation in an Adult: A Case of Brachialis Tendon Entrapment.

Cureus 2019 Jan 21;11(1):e3924. Epub 2019 Jan 21.

Orthopedics and Traumatology, İzmir Bozyaka Training and Research Hospital, Izmir, TUR.

Isolated traumatic anteromedial radial head dislocation is an uncommon injury in adults. The brachialis tendon interposition rarely interferes with the radial head reduction procedure. In the present paper, we report the case of an 18-year-old male who sustained an injury to his right elbow during a wrestling match and developed isolated anteromedial radial head dislocation. Read More

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http://dx.doi.org/10.7759/cureus.3924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433092PMC
January 2019
1 Read

Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response.

Sci Rep 2019 Apr 1;9(1):5447. Epub 2019 Apr 1.

Department of Biology, University of Rome "Tor Vergata", Rome, Italy.

Heterotopic ossification (HO) is a pathological condition characterized by the deposition of mineralized tissue in ectopic locations such as the skeletal muscle. The precise cellular origin and molecular mechanisms underlying HO are still debated. In our study we focus on the differentiation of mesoangioblasts (MABs), a population of multipotent skeletal muscle precursors. Read More

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http://dx.doi.org/10.1038/s41598-019-41926-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443689PMC
April 2019
1 Read

Heterotopic ossification following suboccipital craniectomy decompression surgery for Chiari malformation type I: case report.

J Neurosurg Pediatr 2019 Mar 29:1-4. Epub 2019 Mar 29.

1Geisel School of Medicine at Dartmouth, Hanover; and.

Suboccipital craniectomy with duraplasty is a commonly performed procedure for children with symptomatic Chiari malformation type I (CM-I). Several dural substitutes are used for duraplasty, ranging from pericranium to synthetic materials. When available, autologous pericranium is often preferred due to its low cost, performance in obtaining a watertight closure, ease of suturing, and absence of immune reaction. Read More

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http://dx.doi.org/10.3171/2019.1.PEDS18680DOI Listing
March 2019
1 Read

Primary retroperitoneal liposarcoma with extensive ossification: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e14996

Department of Hepatopancreatobiliary Surgery.

Rationale: Primary retroperitoneal liposarcoma, which originates from mesenchymal tissues, can rarely present with extensive ossification.

Patient Concerns: A 41-year-old male patient presented with a chief complaint of discomfort around the waist for 2 months.

Diagnoses: Computerized tomography (CT) and magnetic resonance imaging suggested a lesion of approximately 5. Read More

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http://dx.doi.org/10.1097/MD.0000000000014996DOI Listing

23-year-old male patient with history of severe traumatic brain injury presents to inpatient rehabilitation with left hip pain and decreased range of motion.

Am J Phys Med Rehabil 2019 Mar 27. Epub 2019 Mar 27.

University of Pittsburgh Medical Center University of Pittsburgh Medical Center.

23-year-old male admitted to inpatient rehabilitation unit following a severe traumatic brain injury secondary to motor vehicle accident. The patient's 71-day acute hospital course was complicated by prolonged coma, respiratory failure requiring tracheostomy placement, pneumonia, sepsis, dysphagia with percutaneous endoscopic gastrostomy placement, spastic left hemiplegia, and bilateral lower extremity deep vein thromboses. Passive range-of-motion of the left hip was limited and painful. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001186DOI Listing
March 2019
2 Reads

Contemporary cemented versus uncemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: a meta-analysis of forty-two thousand forty-six hips.

Int Orthop 2019 Mar 27. Epub 2019 Mar 27.

Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Introduction: Controversy exists regarding the use of cement for hemiarthroplasty to treat displaced intracapsular hip fractures. The aim of this systematic review and meta-analysis was to compare the clinical outcomes between contemporary cemented and contemporary uncemented hemiarthroplasty for the treatment of displaced femoral neck fractures.

Methods: Literature searches of PubMed, Scopus, Web of Science, and Cochrane Central, up to May 2017, were performed. Read More

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http://link.springer.com/10.1007/s00264-019-04325-x
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http://dx.doi.org/10.1007/s00264-019-04325-xDOI Listing
March 2019
10 Reads

Chondroid and osseous metaplasia in an incidental type II papillary renal cell carcinoma with extensive solid areas: an unraveled molecular character.

Authors:
Ayesha Ahmed

Pan Afr Med J 2018 13;31:26. Epub 2018 Sep 13.

Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia.

Chondroid and osseous metaplasia in a Type II Papillary renal cell carcinoma (PRCC) with extensive solid areas is a complex histological combination that has not been reported before. A 21 years old male presented with a comminuted fracture of right femur. On hematological investigations he was found to have low RBC count and hemoglobin. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.26.16137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430846PMC
April 2019
1 Read

Determining the effective timing of an open arthrolysis for post-traumatic elbow stiffness: a retrospective cohort study.

BMC Musculoskelet Disord 2019 Mar 25;20(1):122. Epub 2019 Mar 25.

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Background: Following trauma, the elbow is the most susceptible to restricted motion among all joints. Open arthrolysis is often performed for post-traumatic elbow stiffness if that stiffness does not improve with non-operative management. However, the optimal timing for performing an open arthrolysis remains controversial. Read More

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http://dx.doi.org/10.1186/s12891-019-2506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434886PMC
March 2019
2 Reads

Gα signaling in skeletal development, homeostasis and diseases.

Curr Top Dev Biol 2019 28;133:281-307. Epub 2018 Dec 28.

Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA, United States. Electronic address:

Skeletal development is exquisitely controlled both spatially and temporally by cell signaling networks. Gα is the stimulatory α-subunit in a heterotrimeric G protein complex transducing the signaling of G-protein-coupled receptors (GPCRs), responsible for controlling both skeletal development and homeostasis. Gα, encoded by the GNAS gene in humans, plays critical roles in skeletal development and homeostasis by regulating commitment, differentiation and maturation of skeletal cells. Read More

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http://dx.doi.org/10.1016/bs.ctdb.2018.11.019DOI Listing
December 2018
1 Read

Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury.

Front Immunol 2019 7;10:377. Epub 2019 Mar 7.

Mater Research Institute - The University of Queensland, Translational Research Institute, Woolloongabba, QLD, Australia.

Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of traumatic brain and spinal cord injuries (SCI) which manifest as abnormal formation of bone tissue in periarticular muscles. NHO are debilitating as they cause pain, partial or total joint ankylosis and vascular and nerve compression. NHO pathogenesis is unknown and the only effective treatment remains surgical resection, however once resected, NHO can re-occur. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417366PMC
March 2019
4 Reads

MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism.

Bone 2019 Mar 19;123:92-102. Epub 2019 Mar 19.

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, United States of America; Department of Cell Biology, Washington University School of Medicine, St. Louis, MO, United States of America; Shriners Hospital for Children - St Louis, St Louis, MO, United States of America. Electronic address:

MicroRNAs are small non-coding RNAs that play important roles in many cellular processes including proliferation, metabolism and differentiation. They function by binding to specific regions within the 3'UTR of target mRNAs resulting in suppression of protein synthesis and modulation of potentially many cellular pathways. We previously showed that miRNA expression levels differed between cells from distinct regions of developing human embryonic long bones. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.020DOI Listing
March 2019
2 Reads

Heterotopic ossification after arthroscopy for hip impingement syndrome.

Chin Med J (Engl) 2019 Apr;132(7):827-833

Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing 100191, China.

Background: Heterotopic ossification (HO) is a known complication of hip arthroscopy. We investigated incidence of HO after hip arthroscopy and determined whether revision for HO improved outcome.

Methods: A retrospective study was conducted on 242 patients (140 men and 102 women, mean age: 36. Read More

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http://Insights.ovid.com/crossref?an=00029330-201904050-0001
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http://dx.doi.org/10.1097/CM9.0000000000000153DOI Listing
April 2019
16 Reads
1.016 Impact Factor

Development process of traumatic heterotopic ossification of the temporomandibular joint in mice.

J Craniomaxillofac Surg 2018 Dec 3. Epub 2018 Dec 3.

Department of Oral & Cranio-maxillofacial Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, No. 639 Zhizaoju Road, Shanghai 200011, China. Electronic address:

Purpose: The exact development process underlying traumatic heterotopic ossification of the temporomandibular joint (THO-TMJ) is largely unclear. In this study, we try to explore the histological development process of THO-TMJ.

Materials And Methods: Condylar cartilage of one-month-old male mice was partially removed from the left joint with small scissors to induce THO-TMJ. Read More

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http://dx.doi.org/10.1016/j.jcms.2018.11.026DOI Listing
December 2018
2 Reads
2.597 Impact Factor

Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling.

Nat Metab 2019 Jan 7;1(1):111-124. Epub 2019 Jan 7.

Department of Medicine III, Technische Universität Dresden, Dresden, Germany.

Transferrin receptor 2 (Tfr2) is mainly expressed in the liver and controls iron homeostasis. Here, we identify Tfr2 as a regulator of bone homeostasis that inhibits bone formation. Mice lacking Tfr2 display increased bone mass and mineralization independent of iron homeostasis and hepatic Tfr2. Read More

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http://www.nature.com/articles/s42255-018-0005-8
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http://dx.doi.org/10.1038/s42255-018-0005-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420074PMC
January 2019
7 Reads

A Case of Progressive Ossifying Fibrodysplasia of Tracheobronchial Respiratory Muscles.

Case Rep Radiol 2019 11;2019:5095343. Epub 2019 Feb 11.

Radiology Department of Bingerville University Hospital, Abidjan, Côte d'Ivoire.

The authors report a case of progressive ossifying myositis (POM) in a 13-year-old boy, revealed by dry cough and dyspnea. Conventional chest x-rays and whole-body CT showed extraskeletal ossification that seems to affect the left bronchial strain and trachea. This lesional topography, if established, not yet described to our knowledge, contrasts with the observations of all the authors, including Munchmeyer, for whom smooth muscles and muscles attached to the skeleton by a single end are spared by the heterotopic ossifications characteristic of the disease. Read More

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http://dx.doi.org/10.1155/2019/5095343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388317PMC
February 2019
1 Read

Radiological and clinical outcomes of cervical disc arthroplasty for the elderly: a comparison with young patients.

BMC Musculoskelet Disord 2019 Mar 18;20(1):115. Epub 2019 Mar 18.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Room 525, 17F, #201, Shih-Pai Road, Sec. 2, Beitou District, Taipei, 11217, Taiwan.

Background: This study aimed to investigate whether cervical disc arthroplasty (CDA) would be equally effective in elderly patients as in the young. The inclusion criteria of published clinical trials for CDA-enrolled patients covered the ages from 18 to 78 years. However, there was a paucity of data addressing the differences of outcomes between older and the younger patients. Read More

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http://dx.doi.org/10.1186/s12891-019-2509-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421705PMC
March 2019
1 Read

[Short term effect of total hip arthroplasty through direct anterior approach for the treatment of ankylosing spondylitis with hip flexion deformity].

Zhongguo Gu Shang 2019 Feb;32(2):141-145

Department of Orthopaedics, the Second Affiliated Hospital of Bengbu Medical College, Bengbu 233040, Anhui, China;

Objective: To investigate the short term clinical efficacy of direct anterior approach(DAA) total hip arthroplasty for the treatment of ankylosing spondylitis with hip flexion deformity.

Methods: From September 2014 to June 2017, 15 cases of ankylosing spondylitis with flexion deformity of the hip were treated with total hip arthroplasty through DAA approach including 12 males(17 hips) and 3 females(4 hips) with an average age of 34.4 years old ranging from 21 to 57 years old. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2019.02.009DOI Listing
February 2019
1 Read

Propranolol and ascorbic acid in control of fibrodysplasia ossificans progressiva flare-ups due to accidental falls.

Intractable Rare Dis Res 2019 Feb;8(1):24-28

UFMG/ Department of Physiology and Biophysics, Belo Horizonte, MG, Brazil.

Fibrodysplasia ossificans progressiva (FOP) is a rare, intractable and devastating genetic connective tissue disorder characterized by progressive ectopic ossification in the soft tissues and skeleton. Three patients, one teenage girl (P1), one male adult (P2) and one male child (P3), were studied and treated with FOPCON (combined formulation of 14 mg of propranolol and 250 mg of ascorbic acid), given three times per day. P1 started treatment in March 2012, P2 in October 2012 and P3 in July 2015. Read More

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http://dx.doi.org/10.5582/irdr.2018.01095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409115PMC
February 2019
5 Reads

Fibro Dysplasia Ossificans Progressiva.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):123-126

Department of Surgery, Military Hospital Rawalpindi, National University of Medical Sciences Pakistan.

We present a case of 7 years old boy with a very rare debilitating autosomal dominant disorder characterized by heterotopic ossification. Fibro dysplasia ossificans progressiva affects 1 in 2 million individuals with only 2 previous cases reported from this region. The disease manifests as multiple foci of bone formation in muscles, fasciae, tendons and ligaments often triggered by trauma. Read More

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March 2019
1 Read

Prospective Evaluation of Radiculitis following Bone Morphogenetic Protein-2 Use for Transforaminal Interbody Arthrodesis in Spine Surgery.

Asian Spine J 2019 Mar 15. Epub 2019 Mar 15.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA.

Study Design: Prospective observational cohort study.

Purpose: This study aims to evaluate the safety and efficacy of bone morphogenetic protein-2 (BMP-2) in transforaminal lumbar interbody fusion (TLIF) with regard to postoperative radiculitis.

Overview Of Literature: Bone morphogenetic protein (BMP) is being used increasingly as an alternative to iliac crest autograft in spinal arthrodesis. Read More

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http://dx.doi.org/10.31616/asj.2018.0277DOI Listing
March 2019
4 Reads

Evolution of heterotopic bone in fibrodysplasia ossificans progressiva: An [F]NaF PET/CT study.

Bone 2019 Mar 8;124:1-6. Epub 2019 Mar 8.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Internal Medicine Section Endocrinology, Amsterdam Bone Center, Amsterdam Movement Sciences, the Netherlands. Electronic address:

Fibrodysplasia ossificans progressiva (FOP) is a rare, autosomal dominant disorder characterized by heterotopic ossification (HO) in muscles, ligaments and tendons. Flare-ups often precede the formation of HO, resulting in immobilization of joints. Due to progression of the disease without signs of a flare-up, co-existence of a chronic progression of HO has been postulated, but conclusive evidence is lacking. Read More

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http://dx.doi.org/10.1016/j.bone.2019.03.009DOI Listing
March 2019
1 Read

A comparison of contracture severity at acute discharge in patients with and without heterotopic ossification: A Burn Model System National Database Study.

J Burn Care Res 2019 Mar 6. Epub 2019 Mar 6.

Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA.

Objective: This study assesses the association between heterotopic ossification and upper extremity contracture by comparing goniometric measured active range of motion outcomes of patients with and without heterotopic ossification.

Methods: Data was obtained from the Burn Model System National Database between 1994 and 2003 for patients over 18 years with elbow contracture at acute discharge. Absolute losses in elbow range of motion were compared for those with and without radiologic evidence of heterotopic ossification (location undefined) and were further examined by burn size subgroups using Wilcoxon rank-sum test. Read More

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http://dx.doi.org/10.1093/jbcr/irz031DOI Listing
March 2019
1 Read

Clinical and radiological evaluation of post total hip arthroplasty patients with acetabulum defect.

J Clin Orthop Trauma 2019 Mar-Apr;10(2):358-363. Epub 2018 May 19.

Department of Orthopedics and Traumatology, Dr. Soetomo General Hospital / Universitas Airlangga, Surabaya, Indonesia.

Background: Total Hip Arthroplasty (THA) is one of many therapies given to hip joint injury patients. The main indication for THA in elderly patients is degenerative diseases of the joints. One of the difficulties encountered in this THA procedure is to overcome the acetabulum deficiency, with Paprosky Classification. Read More

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http://dx.doi.org/10.1016/j.jcot.2018.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383129PMC
May 2018
4 Reads

Corrigendum to 'Conserved signaling pathways underlying heterotopic ossification' [Bone, 109, April 2018, 43-48].

Bone 2019 May 28;122:254. Epub 2019 Feb 28.

School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China; Department of Medical Laboratory Science, Bengbu Medical College, Bengbu 233030, China; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.02.023DOI Listing
May 2019
1 Read

Characterization of neuromas in peripheral nerves and their effects on heterotopic bone formation.

Mol Pain 2019 Jan-Dec;15:1744806919838191

1 Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital, Houston, TX, USA.

The formation of neuromas involves expansion of the cellular components of peripheral nerves. The onset of these disorganized tumors involves activation of sensory nerves and neuroinflammation. Particularly problematic in neuroma is arborization of axons leading to extreme, neuropathic pain. Read More

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http://dx.doi.org/10.1177/1744806919838191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440042PMC
March 2019
2 Reads

Modified fibula free flap harvesting technique for prevention of heterotopic pedicle ossification.

Head Neck 2019 Feb 27. Epub 2019 Feb 27.

Department of Oral and Maxillofacial Surgery, Louisiana State University School of Dentistry, New Orleans, Louisiana.

Background: Pedicle ossification is thought to arise from the residual perieosteum left along the pedicle during the fibula free flap (FFF) harvesting. Pedicle ossification in head and neck reconstruction can cause trismus, pain on mastication/turning the neck, or neck swelling.

Methods: Two patients reported in this article developed severe trismus within 6 months after mandibular reconstruction with FFF. Read More

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http://dx.doi.org/10.1002/hed.25711DOI Listing
February 2019
2 Reads

Intrawound Antibiotic Powder Decreases Frequency of Deep Infection and Severity of Heterotopic Ossification in Combat Lower Extremity Amputations.

Clin Orthop Relat Res 2019 Apr;477(4):802-810

Uniformed Services University - Walter Reed Department of Surgery, Bethesda, MD, USA.

Background: Amputations sustained owing to combat-related blast injuries are at high risk for deep infection and development of heterotopic ossification, which can necessitate reoperation and place immense strain on the patient. Surgeons at our institution began use of intrawound antibiotic powder at the time of closure in an effort to decrease the rate of these surgical complications after initial and revision amputations, supported by compelling clinical evidence and animal models of blast injuries. Antibiotic powder may be useful in reducing the risk of these infections, but human studies on this topic thus far have been inconclusive. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000090DOI Listing
April 2019
1 Read

Union Rates and Reported Range of Motion Are Acceptable After Open Forearm Fractures in Military Combatants.

Clin Orthop Relat Res 2019 Apr;477(4):813-820

K. E. Nappo, B. W. Hoyt, G. C. Balazs, G. P. Nanos, D. F. Ipsen, S. M. Tintle, E. M. Polfer, Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA; and the Department of Orthopaedics, Walter Reed National Military Medical Center, Bethesda, MD, USA.

Background: High-energy open forearm fractures are unique injuries frequently complicated by neurovascular and soft tissue injuries. Few studies have evaluated the factors associated with nonunion and loss of motion after these injuries, particularly in the setting of blast injuries.

Questions/purposes: (1) In military service members with high-energy open forearm fractures, what proportion achieved primary or secondary union? (2) What is the pronation-supination arc of motion as stratified by the presence or absence of heterotopic ossification (HO) and synostosis? (3) What are the risks of heterotopic ossification and synostosis? (4) What factors may be associated with forearm fracture nonunion?

Methods: A retrospective study of all open forearm fractures treated at a tertiary military referral center from January 2004 to December 2014 was performed. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000645DOI Listing
April 2019
4 Reads

Heterotopic Ossification in Hip Arthroscopy: an Updated Review.

Curr Rev Musculoskelet Med 2019 Feb 27. Epub 2019 Feb 27.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University, 1200 Main St. West, 4E15, Hamilton, ON, L8N 3Z5, Canada.

Purpose Of Review: Heterotopic ossification (HO) in hip arthroscopy is a common post-operative complication. This review was undertaken to provide an update (2014 present) on the current literature regarding HO in hip arthroscopy.

Recent Findings: Risk factors for HO post-hip arthroscopy include male gender, mixed impingement, picture, and the size of CAM resection. Read More

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http://dx.doi.org/10.1007/s12178-019-09543-9DOI Listing
February 2019
2 Reads

Hepatocyte growth factor plays a dual role in tendon-derived stem cell proliferation, migration, and differentiation.

J Cell Physiol 2019 Feb 26. Epub 2019 Feb 26.

Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Heterotopic ossification is common in tendon healing after trauma, but the detailed mechanisms remain unknown. Tendon-derived stem cells (TDSCs) are a type of progenitor cell found in the tendon niche, and their incorrect differentiation after trauma may lead to tendon calcification. The expression of hepatocyte growth factor (HGF) presents drastic fluctuations in serum/tissue after trauma and was found to activate quiescent stellate cells and contribute to wound healing; however, its potential role in TDSCs remains elusive. Read More

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http://dx.doi.org/10.1002/jcp.28360DOI Listing
February 2019
3 Reads
3.839 Impact Factor

Heterotopic ossification with fever of unknown origin.

CMAJ 2019 Feb;191(8):E232

Department of Cardiovascular Medicine (Godo), Tohoku University Graduate School of Medicine; Department of Emergency and Critical Care Medicine (Godo, Kushimoto), Tohoku University Hospital; Division of Emergency and Critical Care Medicine (Kushimoto), Tohoku University Graduate School of Medicine, Sendai, Japan.

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http://dx.doi.org/10.1503/cmaj.180617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389456PMC
February 2019
1 Read

System Setup to Deliver Air Impact Forces to a Sheep Limb: Preparation for Model Development of Blast-Related Heterotopic Ossification.

JMIR Res Protoc 2019 Feb 22;8(2):e12107. Epub 2019 Feb 22.

Department of Orthopaedics, University of Utah, Salt Lake City, UT, United States.

Background: Heterotopic ossification (HO) is a significant complication for wounded warriors with traumatic limb loss. Although this pathologic condition negatively impacts the general population, ectopic bone has been observed with higher frequency for service members injured in Iraq and Afghanistan due to blast injuries. Several factors, including a traumatic insult, bioburden, tourniquet and wound vacuum usage, and bone fractures or fragments have been associated with increased HO for service members. Read More

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http://dx.doi.org/10.2196/12107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406231PMC
February 2019
4 Reads

Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation.

Stem Cells 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of transforming growth factor-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inactivation of TAK1 to promote cellular proliferation, followed by reactivation to elicit differentiation and extracellular matrix production. Read More

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http://dx.doi.org/10.1002/stem.2991DOI Listing
February 2019
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Regulatory effect of miR-421 on humeral fracture and heterotopic ossification in elderly patients.

Exp Ther Med 2019 Mar 2;17(3):1903-1911. Epub 2019 Jan 2.

Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

The present study aimed to investigate the role of miR-421 and bone morphogenetic protein-2 (BMP-2) in the bone tissues and blood of elderly patients with humeral fractures and heterotopic ossification. A total of 38 patients with humeral fractures, including 16 patients who received surgery within 1-7 days of fracture and 22 patients who received surgery within 8-14 days of fracture, were enrolled. An additional 18 patients who had heterotopic ossification and 26 patients who had humeral fracture and not heterotopic ossification were also included. Read More

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http://dx.doi.org/10.3892/etm.2019.7146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364234PMC
March 2019
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Postoperative Heterotopic Ossification After Cervical Disc Replacement Is Likely a Reflection of the Degeneration Process.

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, China.

Background: The cause of postoperative heterotopic ossification (HO) after cervical disc replacement (CDR) is unclear. The aim of the present study was to investigate the incidence of HO, its clinical significance, and whether the degree of preoperative degeneration was associated with its occurrence.

Methods: Patients who had undergone CDR using the Prestige-LP disc with a minimum of 48 months of follow-up were included. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.244DOI Listing
February 2019
4 Reads

Repair and augmentation of the lateral collateral ligament complex using internal bracing in dislocations and fracture dislocations of the elbow restores stability and allows early rehabilitation.

Knee Surg Sports Traumatol Arthrosc 2019 Feb 14. Epub 2019 Feb 14.

Sporthopaedicum, Straubing and Regensburg, Bahnhofplatz, 27, 94315, Straubing, Germany.

Purpose: Most elbow dislocations can be treated conservatively, with surgery indicated in special circumstances. Surgical options, apart from fracture fixation, range from repair or reconstruction of the damaged ligaments to static external fixation, usually entailing either a long period of immobilization followed by carefully monitored initiation of movement or dynamic external fixation. In general, no consensus regarding surgical treatment has been reached. Read More

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http://dx.doi.org/10.1007/s00167-019-05402-9DOI Listing
February 2019
6 Reads

Cementless hip arthroplasty and transverse shortening femoral osteotomy with the S-ROM stem for Crowe type IV developmental dysplasia.

Eur J Orthop Surg Traumatol 2019 Feb 13. Epub 2019 Feb 13.

II. University Department of Orthopaedic and Trauma Surgery, University Hospital Bratislava, Antolska 11, 851 07, Bratislava, Slovak Republic.

Introduction: The aim of this study has been to present outcomes after cementless arthroplasty for developmental dysplasia Crowe type IV of the hip, with transverse subtrochanteric shortening osteotomy and using the S-ROM stem.

Methods: We evaluated radiographs, functional scores and complications in a consecutive series of 23 patients (28 hips) with high dislocation of the hip. The average age of patients at surgery was 49. Read More

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http://dx.doi.org/10.1007/s00590-019-02400-yDOI Listing
February 2019
11 Reads

Stemless hip arthroplasty versus traditional implants: a comparative observational study at 30 months follow-up.

Hip Int 2018 Nov;28(2_suppl):21-27

Department of Orthopaedics, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction:: The aim of this retrospective case-control study is to evaluate clinical and radiographic results of short stems compared with traditional hip prostheses.

Methods:: 46 short stems (SS) and 50 traditional stems (TS) were selected. All the stems were implanted by the same surgeon using posterior approach because of primary osteoarthritis, post-traumatic osteoarthritis and avascular necrosis. Read More

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http://dx.doi.org/10.1177/1120700018813209DOI Listing
November 2018
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MRI findings, metal ion levels and clinical outcome of a complete series of large metal on metal THA: what's really going on?

Hip Int 2018 Nov;28(2_suppl):48-53

2 IRCCS Istituto Ortopedico Galeazzi, Hip Department, Milan, Italy.

Introduction:: Metal-on-metal (MoM) large head total hip arthroplasties (THAs) were discontinued early after their introduction because of the high number of failures due to adverse reaction to metal debris (ARMD). Aim of this study is to report the clinical outcome at a mid-term follow-up (FU) of a series of large-head MoM THA.

Methods:: In this prospective study, 25 hips (24 patients, 3 males, 21 females, mean age 62. Read More

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http://dx.doi.org/10.1177/1120700018813223DOI Listing
November 2018
2 Reads

Bilateral Spontaneous Bony Ankylosis of the Elbow Following Burn: A Case Report and Review of the Literature.

J Orthop Case Rep 2018 Sep-Oct;8(5):43-46

Department of Orthopaedics, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi - 110076, India.

Introduction: Ankylosis of a joint could be intra-articular or extra-articular. Intra-articular ankylosis may be fibrous or bony. Soft tissue contracture and heterotopic ossification area common finding in patients with a deep burn around the joints. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367284PMC
February 2019
2 Reads