10,123 results match your criteria Heterotopic Ossification


Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation.

Stem Cells 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of TGF-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inactivation of TAK1 to promote cellular proliferation, followed by re-activation to elicit differentiation and extracellular matrix (ECM) production. Read More

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http://dx.doi.org/10.1002/stem.2991DOI Listing
February 2019

Regulatory effect of miR-421 on humeral fracture and heterotopic ossification in elderly patients.

Exp Ther Med 2019 Mar 2;17(3):1903-1911. Epub 2019 Jan 2.

Department of Anesthesiology, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

The present study aimed to investigate the role of miR-421 and bone morphogenetic protein-2 (BMP-2) in the bone tissues and blood of elderly patients with humeral fractures and heterotopic ossification. A total of 38 patients with humeral fractures, including 16 patients who received surgery within 1-7 days of fracture and 22 patients who received surgery within 8-14 days of fracture, were enrolled. An additional 18 patients who had heterotopic ossification and 26 patients who had humeral fracture and not heterotopic ossification were also included. Read More

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http://dx.doi.org/10.3892/etm.2019.7146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364234PMC

Postoperative Heterotopic Ossification after Cervical Disc Replacement Is Likely A Reflection of The Degeneration Process.

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Orthopedics, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu 610041, Sichuan Province, China.

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http://dx.doi.org/10.1016/j.wneu.2019.01.244DOI Listing
February 2019

Operative management of acetabulum fractures in the obese patient: challenges and solutions.

Orthop Res Rev 2017 7;9:75-81. Epub 2017 Aug 7.

Department of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, USA,

In this review, we aim to increase our knowledge of the treatment of acetabular fractures in the obese patient population. The extremely high incidence of obesity in the USA is a looming health care concern that impacts aspects of health care in all medical specialties. There are specific concerns to the orthopedic surgeon when treating obese patients for acetabular fracture. Read More

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http://dx.doi.org/10.2147/ORR.S113424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209371PMC

Repair and augmentation of the lateral collateral ligament complex using internal bracing in dislocations and fracture dislocations of the elbow restores stability and allows early rehabilitation.

Knee Surg Sports Traumatol Arthrosc 2019 Feb 14. Epub 2019 Feb 14.

Sporthopaedicum, Straubing and Regensburg, Bahnhofplatz, 27, 94315, Straubing, Germany.

Purpose: Most elbow dislocations can be treated conservatively, with surgery indicated in special circumstances. Surgical options, apart from fracture fixation, range from repair or reconstruction of the damaged ligaments to static external fixation, usually entailing either a long period of immobilization followed by carefully monitored initiation of movement or dynamic external fixation. In general, no consensus regarding surgical treatment has been reached. Read More

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http://dx.doi.org/10.1007/s00167-019-05402-9DOI Listing
February 2019
1 Read

Cementless hip arthroplasty and transverse shortening femoral osteotomy with the S-ROM stem for Crowe type IV developmental dysplasia.

Eur J Orthop Surg Traumatol 2019 Feb 13. Epub 2019 Feb 13.

II. University Department of Orthopaedic and Trauma Surgery, University Hospital Bratislava, Antolska 11, 851 07, Bratislava, Slovak Republic.

Introduction: The aim of this study has been to present outcomes after cementless arthroplasty for developmental dysplasia Crowe type IV of the hip, with transverse subtrochanteric shortening osteotomy and using the S-ROM stem.

Methods: We evaluated radiographs, functional scores and complications in a consecutive series of 23 patients (28 hips) with high dislocation of the hip. The average age of patients at surgery was 49. Read More

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http://dx.doi.org/10.1007/s00590-019-02400-yDOI Listing
February 2019
5 Reads

Stemless hip arthroplasty versus traditional implants: a comparative observational study at 30 months follow-up.

Hip Int 2018 Nov;28(2_suppl):21-27

Department of Orthopaedics, Università Cattolica del Sacro Cuore-Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Introduction:: The aim of this retrospective case-control study is to evaluate clinical and radiographic results of short stems compared with traditional hip prostheses.

Methods:: 46 short stems (SS) and 50 traditional stems (TS) were selected. All the stems were implanted by the same surgeon using posterior approach because of primary osteoarthritis, post-traumatic osteoarthritis and avascular necrosis. Read More

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http://dx.doi.org/10.1177/1120700018813209DOI Listing
November 2018
1 Read

MRI findings, metal ion levels and clinical outcome of a complete series of large metal on metal THA: what's really going on?

Hip Int 2018 Nov;28(2_suppl):48-53

2 IRCCS Istituto Ortopedico Galeazzi, Hip Department, Milan, Italy.

Introduction:: Metal-on-metal (MoM) large head total hip arthroplasties (THAs) were discontinued early after their introduction because of the high number of failures due to adverse reaction to metal debris (ARMD). Aim of this study is to report the clinical outcome at a mid-term follow-up (FU) of a series of large-head MoM THA.

Methods:: In this prospective study, 25 hips (24 patients, 3 males, 21 females, mean age 62. Read More

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http://dx.doi.org/10.1177/1120700018813223DOI Listing
November 2018
1 Read

Bilateral Spontaneous Bony Ankylosis of the Elbow Following Burn: A Case Report and Review of the Literature.

J Orthop Case Rep 2018 Sep-Oct;8(5):43-46

Department of Orthopaedics, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi - 110076, India.

Introduction: Ankylosis of a joint could be intra-articular or extra-articular. Intra-articular ankylosis may be fibrous or bony. Soft tissue contracture and heterotopic ossification area common finding in patients with a deep burn around the joints. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367284PMC
February 2019
2 Reads

Risk factors for complications and adverse outcomes in polytrauma patients with associated upper extremity injuries.

Patient Saf Surg 2019 4;13. Epub 2019 Feb 4.

1Department of Trauma, Universitaetsspital, University of Zurich, Raemistr.100, 8091 Zurich, Switzerland.

Background: In terms of upper extremity fractures by patients with multiple injuires, a lot of studies have assessed the functional outcome following trauma to have less favorable outcomes in regards to functional recovery. We tested the hypothesis that differences in clinical outcome occur between shaft and articular injuries of the upper extremity, when patients that sustained neurologic deficits (e.g. Read More

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https://pssjournal.biomedcentral.com/articles/10.1186/s13037
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http://dx.doi.org/10.1186/s13037-019-0187-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360674PMC
February 2019
2 Reads

Surgical treatment of postburn heterotopic ossification around the elbow: Three case reports.

Medicine (Baltimore) 2019 Feb;98(6):e14403

Department of Orthopedic Surgery, MacKay Memorial Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, Taiwan, ROC.

Rationale: Heterotopic ossification (HO), which is defined as the formation of new bone in tissues that do not normally ossify, is an infrequent yet debilitating complication of burns. Herein, we report three patients who suffered from elbow HO after burn injury due to a dust explosion event. This is a case report that includes the most cases involved in a single mass casualty incident in the presented literature. Read More

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http://dx.doi.org/10.1097/MD.0000000000014403DOI Listing
February 2019
1 Read

Characterization of Chest Wall Toxicity during Long Term Follow Up after Thoracic Stereotactic Body Radiotherapy.

Pract Radiat Oncol 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiation Oncology, Virginia Commonwealth University Health Systems, Richmond, VA, USA.

Purpose: Chest wall (CW) pain and rib fractures are frequently diagnosed following stereotactic body radiotherapy (SBRT) for malignant lung tumors. We hypothesize that multiple risk factors including bone mineral density (BMD) are associated with CW toxicity and that CW pain and rib fractures often evolve into chronic clinical problems.

Methods: 118 lung tumors treated with SBRT in 100 patients with a minimum follow up of 2 years were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.prro.2019.01.012DOI Listing
February 2019
2 Reads

The Addition of Hip Arthroscopy to Periacetabular Osteotomy Does Not Increase Complication Rates: A Prospective Case Series.

Am J Sports Med 2019 Feb 7:363546518820528. Epub 2019 Feb 7.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Background:: Previous studies on periacetabular osteotomy (PAO) reported complication and reoperation rates of 5.9% and 10%, respectively. Hip arthroscopy is increasingly utilized as an adjunct procedure to PAO to precisely treat associated intra-articular pathology. Read More

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http://dx.doi.org/10.1177/0363546518820528DOI Listing
February 2019
2 Reads

Outcomes of distal biceps tendon reattachment using the ToggleLoc™ fixation device with ZipLoop™ technology with single mini-open technique.

Eur J Orthop Surg Traumatol 2019 Feb 7. Epub 2019 Feb 7.

Institut chirurgical de la main et du membre supérieur, 17 avenue Condorcet, 69100, Villeurbanne, France.

Anatomical repair of distal biceps tendon ruptures has been shown to restore elbow supination and flexion strength. Here, we report the outcomes of distal biceps tendon reattachment using the ToggleLoc fixation device with ZipLoop technology through a single incision. This was a retrospective study of 38 patients with a mean age of 49. Read More

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http://dx.doi.org/10.1007/s00590-019-02376-9DOI Listing
February 2019
1 Read

Yoga-Induced Myositis Ossificans Traumatica of the Scapholunate Ligament.

J Wrist Surg 2019 Feb 26;8(1):80-83. Epub 2018 Jun 26.

Department of Orthopaedic Surgery, Cedars Sinai Medical Center, Los Angeles, California.

 Myositis ossificans traumatica (MOT) involves the heterotopic development of lamellar bone after a traumatic injury. Despite being termed "myositis," MOT is not limited to muscle but rather can involve tendons, fat, and fascia. "Traumatica" reflects that lesions are usually associated with a history of significant trauma, that is, fractures or surgery; however, many reports suggest they can also be linked to repetitive low-energy insults. Read More

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http://dx.doi.org/10.1055/s-0038-1661354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358443PMC
February 2019
1 Read

Distal Radioulnar Joint Replacement in the Scarred Wrist.

J Wrist Surg 2019 Feb 19;8(1):55-60. Epub 2018 Sep 19.

Department of Orthopaedic Surgery, Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Yawkey Center, Boston, Massachusetts.

 Radiocarpal or midcarpal arthritis can occur simultaneously with arthritis of the distal radioulnar joint (DRUJ), leading to functional impairment of the wrist. Treatment often involves wrist arthroplasty or arthrodesis, either with simultaneous or secondary procedures, addressing the DRUJ. Successful treatment of solitary DRUJ arthritis with DRUJ replacement has been reported. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1670681
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http://dx.doi.org/10.1055/s-0038-1670681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358447PMC
February 2019
8 Reads

Blocking neuromuscular junctions with botulinum toxin A injection enhances neurological heterotopic ossification development after spinal cord injury in mice.

Ann Phys Rehabil Med 2019 Feb 1. Epub 2019 Feb 1.

Stem Cell Biology Laboratory, Cancer Care and Biology Program, Mater Research, University of Queensland, Woolloongabba, Queensland, Australia; School of Medicine, University of Queensland, Herston, Queensland, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.rehab.2019.01.005DOI Listing
February 2019
1 Read

Heterotopic Ossification in Primary Total Hip Arthroplasty: which is the role of drainage?

Acta Biomed 2019 Jan 10;90(1-S):92-97. Epub 2019 Jan 10.

clinic of orthopaedics, University Hospital of Udine.

Background And Aim Of The Work: The Heterotopic Ossification (HO) is a common complication following Total Hip Arthroplasty (THA). Although there is no concordance in Literature regarding the etiopathogenic mechanism, various HO risk factors have been recognized, both related to the patient and associated with the surgical procedureLiterature does not consider the use of intra-articular drainage as a possible risk factor. Our hypothesis is that this item can contribute to the development of HO. Read More

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http://dx.doi.org/10.23750/abm.v90i1-S.8077DOI Listing
January 2019
3 Reads

Editorial Commentary: Hip Arthroscopy-The Tissue-Friendly Evolution.

Authors:
Niraj V Kalore

Arthroscopy 2019 Feb;35(2):657-658

The field of hip arthroscopy is saturated with low-level studies. A systematic review of these low-level studies provides low-level evidence favoring tissue-friendly restorative techniques such as labral repair and capsular repair over nonrestorative techniques such as labral debridement and capsulotomy. Iatrogenic complications such as nerve injuries and heterotopic ossification remain the most common complications of hip arthroscopy. Read More

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http://dx.doi.org/10.1016/j.arthro.2018.11.048DOI Listing
February 2019
1 Read

Systematic Review of Hip Arthroscopy for Femoroacetabular Impingement: The Importance of Labral Repair and Capsular Closure.

Arthroscopy 2019 Feb;35(2):646-656.e3

Section of Young Adult Hip Surgery, Division of Sports Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.. Electronic address:

Purpose: To evaluate the safety and efficacy of hip arthroscopy for femoroacetabular impingement syndrome by assessing complications, comprehensive procedure survivorship, and the influence of labral and capsular management on procedure survivorship.

Methods: A systematic review of multiple medical databases was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and checklist. All clinical outcome studies that reported on the presence or absence of reoperation after hip arthroscopy for femoroacetabular impingement syndrome were eligible for inclusion. Read More

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http://dx.doi.org/10.1016/j.arthro.2018.09.005DOI Listing
February 2019
2 Reads

Clinical outcomes and quality of life after total hip arthroplasty in adult patients with a history of infection of the hip in childhood: a mid-term follow-up study.

J Orthop Surg Res 2019 Feb 1;14(1):38. Epub 2019 Feb 1.

Department of Orthopedics, West China Hospital, Sichuan University, 37# Wainan Guoxue Road, Chengdu, 610041, Sichuan, People's Republic of China.

Background: Total hip arthroplasty for adult patients with a history of infection of the hip in childhood could be a more technically demanding procedure due to complicated anatomy and the possibility of reinfection. Here, we conducted a mid-term analysis of clinical outcomes in such patients after primary cementless total hip arthroplasty (THA).

Methods: We reviewed 101 patients (101 hips; 51 men; mean age, 52. Read More

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http://dx.doi.org/10.1186/s13018-019-1074-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359810PMC
February 2019
2 Reads

Response to comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.

Elife 2019 Jan 30;8. Epub 2019 Jan 30.

Department of Molecular and Cell Biology, University of Connecticut, Storrs, United States.

We respond to concerns expressed by Pacifici and Shore (2019) about a recent paper (Lees-Shepard and Goldhamer, 2018a) in which we reported that the drug palovarotene can have severe side effects in a mouse model of fibrodysplasia ossificans progressiva. Read More

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http://dx.doi.org/10.7554/eLife.43928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353591PMC
January 2019
1 Read

Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.

Elife 2019 Jan 30;8. Epub 2019 Jan 30.

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, United States.

We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018). Read More

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http://dx.doi.org/10.7554/eLife.43173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353590PMC
January 2019
2 Reads

Combined Pelvic Ring Disruption and Acetabular Fracture: Outcomes Using a Sequential Reduction Protocol and an Anterior Subcutaneous Pelvic Fixator (INFIX).

J Orthop Trauma 2019 Feb;33 Suppl 2:S66-S71

Detroit Medical Center, Michigan State University, Detroit, MI.

Objective: The purposes of this article were to (1) compare our combined pelvic ring and acetabular fracture patients' rate of mortality and Injury Severity Score (ISS) to those of patients with isolated injuries at our center and to those with combined injuries as reported in the literature, (2) describe our treatment algorithm using the INFIX for these combination injuries, and (3) report our patients' radiographic and functional outcomes.

Design: Retrospective IRB-approved case series and literature review.

Setting: US Level 1 Trauma Center. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001416DOI Listing
February 2019
1 Read

Loss of pronation-supination in patients with heterotopic ossification around the elbow.

J Shoulder Elbow Surg 2019 Jan 23. Epub 2019 Jan 23.

Department of Orthopedics, Biomechanics Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Heterotopic ossification (HO) is a well-recognized cause of limited flexion-extension, but it can also limit pronation-supination. There is a paucity of literature concerning restriction of pronation-supination due to HO.

Methods: We conducted a retrospective review of patients who had undergone elbow surgery for HO removal between January 1, 2003, and September 27, 2013. Read More

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http://dx.doi.org/10.1016/j.jse.2018.10.029DOI Listing
January 2019
1 Read

Comparison of the modified Heuter approach and the Kocher-Langenbeck approach in the treatment of Pipkin type I and type II femoral head fractures.

Int Orthop 2019 Jan 25. Epub 2019 Jan 25.

Department of Orthopedics, West China Hospital, Sichuan University, 37# Wainan Guoxue Road, Chengdu, 610041, People's Republic of China.

Purpose: To evaluate and compare the effectiveness of the modified Heuter approach and the Kocher-Langenbeck approach in the treatment of Pipkin type I and II femoral head fractures.

Methods: The study cohort consisted of 39 patients with Pipkin type I or type II femoral head fractures who were treated by open reduction and internal fixation through the modified Heuter approach (the Heuter group) or the Kocher-Langenbeck approach (the K-L group) between June 2013 and January 2016. Standard radiographs and computed tomography (CT) scans were obtained before surgery and during the follow-up. Read More

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http://link.springer.com/10.1007/s00264-019-04301-5
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http://dx.doi.org/10.1007/s00264-019-04301-5DOI Listing
January 2019
4 Reads
2.019 Impact Factor

Traumatic hip fracture-dislocation: A middle-term follow up study and a proposal of new classification system of hip joint associated injury.

Injury 2019 Jan 17. Epub 2019 Jan 17.

Section of Orthopaedics and Trauma Surgery, Ospedali Riuniti, Ancona, Italy. Electronic address:

Traumatic hip fracture dislocation is a rare injury associated with high-energy trauma. Most of these injuries should be surgically treated. Hip dislocation is an orthopaedic emergency and reduction must be performed within 6-8 hours of trauma. Read More

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http://dx.doi.org/10.1016/j.injury.2019.01.011DOI Listing
January 2019

Heterotopic Ossification Under an Anterior Labroligamentous Periosteal Sleeve Avulsion Lesion That Was Incorrectly Identified as a Fracture of the Anterior Glenoid Rim (a Bony Bankart Lesion): A Report of 3 Cases.

Authors:
Terry A Hammond

JBJS Case Connect 2019 Jan 23. Epub 2019 Jan 23.

The Shoulder Clinic, Orthopaedic Surgery and Sports Medicine Centre, Benowa, Queensland, Australia.

Cases: Senior musculoskeletal radiologists diagnosed fractures of the anterior glenoid rim (osseous Bankart lesions) in 3 patients with shoulder instability who had routine imaging. However, additional assessment suggested that the images were more consistent with heterotopic ossification under an anterior labroligamentous periosteal sleeve avulsion (ALPSA) lesion with no true osseous Bankart lesion and no substantial bone loss.

Conclusion: Recognition of the lesion described in this article is important to prevent potential misdiagnosis and may assist in surgical decision-making. Read More

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http://dx.doi.org/10.2106/JBJS.CC.18.00104DOI Listing
January 2019
1 Read

Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats.

J Cell Mol Med 2019 Jan 22. Epub 2019 Jan 22.

Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, PR China.

Despite the fact that extensive studies have focused on heterotopic ossification (HO), its molecular mechanism remains unclear. The endothelial-mesenchymal transition (EndMT), which may be partially modulated by neuroendocrine cytokines is thought to play a major role in HO. Neurotrophin-3 (NT-3), which has neuroendocrine characteristics is believed to promote skeletal remodeling. Read More

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http://doi.wiley.com/10.1111/jcmm.14150
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http://dx.doi.org/10.1111/jcmm.14150DOI Listing
January 2019
5 Reads

Complications of open reduction and internal fixation of distal humerus fractures.

EFORT Open Rev 2018 Oct 24;3(10):558-567. Epub 2018 Oct 24.

First Department of Orthopedic Surgery, National and Kapodistrian University of Athens, Attikon Hospital, Athens, Greece.

Treatment of distal humerus fractures is demanding. Surgery is the optimal treatment and preoperative planning is based on fracture type and degree of comminution.Fixation with two precontoured anatomical locking plates at 90:90 orthogonal or 180 parallel is the optimal treatment. Read More

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http://dx.doi.org/10.1302/2058-5241.3.180009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335604PMC
October 2018
4 Reads

Apophyseal avulsion fractures of the pelvis. A review.

Acta Biomed 2018 11 15;89(4):470-476. Epub 2018 Nov 15.

Dipartimento Scienze Chirurgiche Ospedale Maggiore Parma, U.O. Clinica Ortopedica.

Background And Aim Of The Work: Fractures of the pelvis classically occur in adolescent during sports activities with forceful and repetitive contractions or passive lengthening acting on not yet ossified growth plates. Their misdiagnosis lead to disability, chronic pain and decrease of performances. Evidence based treatment guidelines do not exist; aim of this paper is to point out clinical outcomes, return to sport rates and complications of surgical and conservative approach. Read More

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http://dx.doi.org/10.23750/abm.v89i4.7632DOI Listing
November 2018
2 Reads

Effects of BMP-2 dose and delivery of microvascular fragments on healing of bone defects with concomitant volumetric muscle loss.

J Orthop Res 2019 Jan 16. Epub 2019 Jan 16.

Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia.

Traumatic composite bone-muscle injuries, such as open fractures, often require multiple surgical interventions and still typically result in long-term disability. Clinically, a critical indicator of composite injury severity is vascular integrity; vascular damage alone is sufficient to assign an open fracture to the most severe category. Challenging bone injuries are often treated with bone morphogenetic protein 2 (BMP-2), an osteoinductive growth factor, delivered on collagen sponge. Read More

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http://doi.wiley.com/10.1002/jor.24225
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http://dx.doi.org/10.1002/jor.24225DOI Listing
January 2019
6 Reads

Artificial disc replacement versus fusion in patients with cervical degenerative disc disease and radiculopathy: a randomized controlled trial with 5-year outcomes.

J Neurosurg Spine 2019 Jan 11:1-9. Epub 2019 Jan 11.

1Department of Surgical Sciences, Uppsala University, Uppsala.

OBJECTIVEThe method of artificial disc replacement (ADR) has been developed as an alternative treatment to fusion surgery after decompression for cervical degenerative disc disease (DDD) with radiculopathy. Preserving the motion of ADR devices aims to prevent immobilization side effects such as adjacent-segment pathology (ASP). However, long-term follow-up evaluations using MRI are needed to investigate if this intent is achieved. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18659DOI Listing
January 2019
3 Reads

Heterotopic ossification after total elbow arthroplasty: a systematic review.

J Shoulder Elbow Surg 2019 Mar 11;28(3):587-595. Epub 2019 Jan 11.

Department of Surgery, St Joseph's Healthcare, Hamilton, ON, Canada.

Background: Heterotopic ossification (HO) is a known complication that can arise after total elbow arthroplasty (TEA). In most cases, it is asymptomatic; however, in some patients, it can limit range of motion and lead to poor outcomes. The objective of this review was to assess and report the incidence, risk factors, prophylaxis, and management of HO after TEA. Read More

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http://dx.doi.org/10.1016/j.jse.2018.10.003DOI Listing
March 2019
6 Reads

Post-erysipela panniculitis ossificans of the lower leg treated with pentoxifylline.

Dermatol Ther 2019 Jan 14:e12821. Epub 2019 Jan 14.

Department of Clinical-Surgical, Diagnostic, and Pediatric Science, Institute of Dermatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

We report the case of a female patient who developed a firm, wooden-like, nonpitting edema of the left lower leg after a dermo-hypodermitis. The clinical picture was accompanied by intense pain, strongly impacting the patient's quality of life. A soft-tissue ultrasound demonstrated several millimetric hyperechoic linear lesions whose histopathological examination was conclusive for panniculitis ossificans. Read More

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http://doi.wiley.com/10.1111/dth.12821
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http://dx.doi.org/10.1111/dth.12821DOI Listing
January 2019
10 Reads

Increased Risk of Heterotopic Ossification Following Revision Hip Arthroplasty for Periprosthetic Joint Infection.

Arch Bone Jt Surg 2018 Nov;6(6):486-491

Research performed at The Rothman Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Background: To investigate whether surgery for Periprosthetic Joint Infection (PJI) of the hip, the number of procedures and their duration contribute to risk of Heterotopic Ossification formation.

Methods: 56 patients with hip PJI undergoing one-stage (10) or two-stage (46) exchange arthroplasty were matched to 112 patients undergoing revision arthroplasty for aseptic failure based on age, gender, body mass index (BMI), surgical approach (all direct lateral) and date of surgery (2006-2013). Patients with Paget's disease and ankylosing spondylitis, or preoperative HO were excluded. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310194PMC
November 2018
4 Reads

BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification.

Stem Cell Res Ther 2019 Jan 11;10(1):14. Epub 2019 Jan 11.

School of Basic Medical Sciences, Anhui Medical University, 81 Meishan road, Hefei, 230032, China.

Background: Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibrodysplasia ossificans progressiva (FOP), is a serious condition without effective treatment. Understanding of the core process of injury-induced HO is still severely limited.

Methods: Double-pulse thymidine analog labeling was used to explore the distinctive domains evolved in injury-induced lesions in an animal model of HO (Nse-BMP4). Read More

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http://dx.doi.org/10.1186/s13287-018-1107-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329163PMC
January 2019
3 Reads

Identification of Heterotopic Ossification Using 18F-NaF PET/CT.

Clin Nucl Med 2019 Jan 4. Epub 2019 Jan 4.

Department of Hematology, Odense University Hospital.

Heterotopic ossification (HO) is a benign condition characterized by the abnormal formation of mature lamellar bone in extraskeletal soft tissues. Most frequently, HO is observed around the hip joint after fractures or surgical procedures such as open reduction internal fixation or total hip arthroplasties. We are presenting a case of HO as detected by F-NaF PET/CT in a 68-year-old woman with multiple myeloma and a history of internal fixation of the right hip. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002448DOI Listing
January 2019
37 Reads

Ascorbic acid diminishes bone morphogenetic protein 2-induced osteogenic differentiation of muscle precursor cells.

Muscle Nerve 2019 Jan 8. Epub 2019 Jan 8.

Medical Sciences Division, Northern Ontario School of Medicine, 955 Oliver Road, Medical School Building, Room 2004, Thunder Bay, Ontario, P7B 5E1, Canada.

Introduction: Muscle precursor cells (MPC) are integral to the maintenance of skeletal muscle and have recently been implicated in playing a role in bone repair. The primary objective of this study was to understand better the role of oxidative stress during the osteogenic differentiation of MPCs.

Methods: Muscle precursor cells were treated with various combinations of ascorbic acid (AA), bone morphogenetic protein (BMP)-2, and either a superoxide dismutase analog (4-hydroxy-TEMPO [TEMPOL]) or polyethyleneglycol-conjugated catalase. Read More

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http://doi.wiley.com/10.1002/mus.26415
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http://dx.doi.org/10.1002/mus.26415DOI Listing
January 2019
10 Reads

Infection Precedes Heterotopic Ossification in Combat Wounded.

US Army Med Dep J 2018 Jul-Dec(2-18):1-5

US Army Institute of Surgical Research.

Heterotopic ossification is the formation of ossified bone in soft tissue, particularly after soft tissue trauma. Heterotopic ossification is known cause of pain, prosthetic/orthotic malfit, and reoperation following combat extremity injury. The purpose of this research was to examine injury and treatment characteristics that are associated with heterotopic ossification in a broader population of deployment-injured subjects. Read More

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January 2019
11 Reads

Optimal strategies for the prevention of heterotopic ossification after total hip arthroplasty: A network meta-analysis.

Int J Surg 2019 Feb 4;62:74-85. Epub 2019 Jan 4.

Department of Orthopaedics, Gansu Provincial Hospital, 204 Donggangxi Road, 730000, Lanzhou, Gansu Province, China. Electronic address:

Background: Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs), selective NSAIDs, and radiation are widely used for the prevention of heterotopic ossification (HO) after total hip arthroplasty (THA). Previous studies have suggested that nonselective NSAIDs, selective NSAIDs and radiation can prevent HO after THA, though the results are conflicting. In this network meta-analysis, we aimed to comprehensively analyze the efficacy and safety of three strategies for preventing HO after THA compared to a placebo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17439191193000
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http://dx.doi.org/10.1016/j.ijsu.2018.12.011DOI Listing
February 2019
13 Reads

Internal fixation of acetabular fractures in an older population using the lateral-rectus approach: short-term outcomes of a retrospective study.

J Orthop Surg Res 2019 Jan 4;14(1). Epub 2019 Jan 4.

Department of Orthopaedic, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, Guangdong Province, China.

Purpose: This study aims to examine the clinical efficacy and surgical techniques of the lateral-rectus approach for treatment of acetabular factures in elderly patients.

Methods: After appropriate exclusion, 65 elderly patients with an acetabular fracture who was treated through the lateral-rectus approach from January 2011 and October 2016 were selected retrospectively. By analyzing the medical records retrospectively, the patients' characteristics, fracture type, mechanism of injury, comorbid conditions, ASA class, operative time, intra-operative blood loss, and post-operative complications were assessed. Read More

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https://josr-online.biomedcentral.com/articles/10.1186/s1301
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http://dx.doi.org/10.1186/s13018-018-1039-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319000PMC
January 2019
8 Reads

Risk factors of efficacy for patients receiving surgical treatment following terrible triad of the elbow joint: A comparative study.

Medicine (Baltimore) 2019 Jan;98(1):e13836

Department of Orthopedics, Lishui Municipal Central Hospital, Lishui Hospital of Zhejiang University, The 5th Affiliated Hospital of Wenzhou Medical University, Lishui, China.

Background: This study aims to explore the efficacy of surgical and conservative treatment for elbow joint terrible triad, and evaluate related factors affecting surgical treatment efficacy.

Methods: Patients with terrible triad of elbow joint (n = 165) were selected, among which 79 cases underwent conservative treatment (the control group) and 86 cases underwent surgical treatment (the experimental group). The range of flexion and extension, range of rotation and Mayo elbow performance score were recorded. Read More

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http://dx.doi.org/10.1097/MD.0000000000013836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344182PMC
January 2019
1 Read

Anterior decompression and fusion versus laminoplasty for cervical myelopathy due to ossification of posterior longitudinal ligament: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(1):e13382

Department of Orthopaedic, Affiliated Hospital of Hebei University.

Background: Both anterior decompression and fusion (ADF) and laminoplasty (LAMP) are frequently used for the treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL). However, some controversies still remained in surgical options. We investigated whether ADF had better neurological outcome than LAMP in the treatment of cervical myelopathy due to OPLL. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901040-0000
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http://dx.doi.org/10.1097/MD.0000000000013382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344170PMC
January 2019
7 Reads

Fibroplasia Ossificans Progressiva: A Case Report of a Rare Disease Entity.

Ethiop J Health Sci 2018 Jul;28(4):513-516

Department of Pediatrics and Child Health, School of Medicine, College of Health Sciences, Addis Ababa University, Ethiopia.

Background: Fibrodysplasia ossificans progressiva (FOP), also known as Myositis ossificans progressiva or Munchmeyer's disease, is an extremely rare and disabling genetic condition of congenital skeletal malformations and progressive heterotopic ossification (HO). The disease is characterized by congenital skeletal anomalies and progressive ectopic bone formation in connective tissues such as ligaments, muscles and tendons. The disease has an incidence of about 1 in 2 million population. Read More

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http://dx.doi.org/10.4314/ejhs.v28i4.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308737PMC
July 2018
6 Reads

Failure of Indomethacin and Radiation to Prevent Blast-induced Heterotopic Ossification in a Sprague-Dawley Rat Model.

Clin Orthop Relat Res 2019 Mar;477(3):644-654

A. D. Robertson, T. P. Nguyen, D. E. Jaffe, J. P. Stains, Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD, USA A. M. Chiaramonti, R. E. Holmes, E. L. Hanna, W. R. Barfield, V. D. Pellegrini, Department of Orthopaedics and Physical Medicine, Medical University of South Carolina, Charleston, SC, USA J. G. Rhee, Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA W. B. Fourney, Department of Mechanical Engineering, University of Maryland, College Park, MD, USA.

Background: Although use of nonsteroidal antiinflammatory drugs and low-dose irradiation has demonstrated efficacy in preventing heterotopic ossification (HO) after THA and surgical treatment of acetabular fractures, these modalities have not been assessed after traumatic blast amputations where HO is a common complication that can arise in the residual limb.

Questions/purposes: The purpose of this study was to investigate the effectiveness of indomethacin and irradiation in preventing HO induced by high-energy blast trauma in a rat model.

Methods: Thirty-six Sprague-Dawley rats underwent hind limb blast amputation with a submerged explosive under water followed by irrigation and primary wound closure. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000594DOI Listing
March 2019
2 Reads
2.765 Impact Factor

Pediatric Terrible Triad Injury of the Elbow: A Rare and Easily Missed Injury: A Case Report.

JBJS Case Connect 2018 Oct-Dec;8(4):e106

Department of Orthopaedics, Southland Hospital/University of Otago, Invercargill, New Zealand.

Case: We report the case of a pediatric terrible triad injury of the elbow consisting of an ulnohumeral dislocation, a radial neck fracture, and a coronoid chondral injury, which was diagnosed at 14 days following injury. We describe our surgical technique and provide details of the postoperative course, including the development of a rotational contracture following heterotopic ossification.

Conclusion: We describe a rare and challenging injury that should be recognized early and managed surgically to maintain acceptable elbow function. Read More

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http://dx.doi.org/10.2106/JBJS.CC.18.00114DOI Listing
January 2019
2 Reads

Treatment of capitellar and trochlear fractures with posterior comminution: minimum 2-year follow-up.

J Shoulder Elbow Surg 2018 Dec 28. Epub 2018 Dec 28.

Department of Orthopedics and Traumatology, Honghui Hospital, Xi'an Jiaotong University Health Science Center, Xi'an, China. Electronic address:

Hypothesis: This study aimed to evaluate the safety and efficacy of the fixation of Dubberley type B capitellar and trochlear fractures using dorsolateral anatomic plates with support of the distal humerus (DAPSDHs).

Methods: Fifteen patients with Dubberley type B capitellar and trochlear fractures (two type 1B, five type 2B, and eight type 3B) were treated through the extended lateral approach, and fixation was achieved with DAPSDHs. Radiographic evaluation was performed, and range of motion of the elbow and forearm was recorded. Read More

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http://dx.doi.org/10.1016/j.jse.2018.09.004DOI Listing
December 2018
1 Read

[Total hip arthroplasty for the treatment of bony ankylosis in patients with ankylosing spondylitis].

Zhongguo Gu Shang 2018 Dec;31(12):1104-1107

Department of Orthopaedics, Zhoushan Hospital of Traditional Chiniese Medicine Affiliated to Zhejiang Chinese Medical University, Zhoushan 316000, Zhejiang, China.

Objective: To evaluate the efficacy of total hip arthroplasty for the treatment of bony ankylosis in patients with ankylosing spondylitis.

Methods: From January 2008 to January 2012, 12 patients (24 hips) with ankylosing spondylitis combined with hip ankylosis were treated with total hip arthroplasty, including 11 males and 1 females, ranging in age from 27 to 62 years old. The course of diseases ranged from 5 to 32 years old. Read More

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http://dx.doi.org/10.3969/j.issn.1003-0034.2018.12.006DOI Listing
December 2018
2 Reads

Treatment of posttraumatic lumbar interspinous ligament calcification with partial resection of spinous processes and calcified interspinous ligaments: case report.

J Neurosurg Spine 2018 Dec 21:1-5. Epub 2018 Dec 21.

The authors report on the first surgical treatment for traumatic interspinous ligament calcification, with significant radiographic and symptomatic improvements at long-term follow-up. Heterotopic ossification occurs following traumatic injury but does not typically affect the interspinous ligaments. While these ligaments can calcify with age, this is rarely seen in patients younger than 50 years of age. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18401DOI Listing
December 2018
12 Reads