8,694 results match your criteria Herz KardiovaskulA¤re Erkrankungen[Journal]
Transfusion 2018 Dec 13. Epub 2018 Dec 13.
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein- Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Background: The cost-benefit question of general screening of blood products for the hepatitis E virus (HEV) is currently being discussed. One central question is the need for individual nucleic acid amplification techniques (NAT) screening (ID-NAT) versus minipool NAT screening (MP-NAT) approaches to identify all relevant viremias in blood donors. Here, the findings of ID-NAT versus MP-NAT in pools of 96 samples were compared. Read More
Acta Anaesthesiol Scand 2018 Dec 11. Epub 2018 Dec 11.
Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Germany.
Background: Remote ischaemic preconditioning (RIPC) can attenuate myocardial ischaemia/reperfusion injury but its underlying mechanisms remain largely unknown. Recently, extracellular vesicles (EVs) containing microRNAs (miRNAs) were shown to mediate distant intercellular communication that may be involved in cardioprotection. We tested the hypothesis that RIPC in anaesthetized patients undergoing coronary artery bypass (CABG) surgery results in the release of EVs from the ischaemic/reperfused arm into the blood stream harbouring cardioprotective miRNAs. Read More
Front Immunol 2018 28;9:2620. Epub 2018 Nov 28.
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Biochemistry, Berlin, Germany.
Viral myocarditis is an inflammation of the heart muscle triggered by direct virus-induced cytolysis and immune response mechanisms with most severe consequences during early childhood. Acute and long-term manifestation of damaged heart tissue and disturbances of cardiac performance involve virus-triggered adverse activation of the immune response and both immunopathology, as well as, autoimmunity account for such immune-destructive processes. It is a matter of ongoing debate to what extent subclinical virus infection contributes to the debilitating sequela of the acute disease. Read More
Dtsch Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.
St.-Josefs-Hospital Cloppenburg, Cloppenburg.
Background: For the prevention of cardiovascular risk factors (RF) there are numerous recommendations of professional societies, which relate to the personal way of life of individuals (for example nutrition/diet, physical activity, stress reduction etc.). The implementation of these recommendations is so far poor. Read More
Sci Rep 2018 Dec 12;8(1):17779. Epub 2018 Dec 12.
Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstraße 11, 32545, Bad Oeynhausen, Germany.
Diminished microRNA-29b levels have recently been revealed to provoke increased expression and accumulation of extracellular matrix molecules, such as collagens in fibrotic remodeling. Subsequently, the aim of this study was to find out whether microRNA-29b might also regulate human xylosyltransferase (XT)-I expression. XT-I has been characterized previously as a fibrosis biomarker catalyzing the key step of proteoglycan biosynthesis. Read More
Diabetes Ther 2018 Dec 6. Epub 2018 Dec 6.
Medical Clinic and Policlinic III at the University Hospital Dresden, Dresden, Germany.
In the original publication, the text in Table 2 stated 'Hypersensitivity to the active substance, to Ferinject, or to any of its excipients'. Read More
Int J Nanomedicine 2018 23;13:7905-7913. Epub 2018 Nov 23.
Department of Radiology, Charité-Universitätsmedizin Berlin, Germany,
Background: Optical coherence tomography (OCT) is an intravascular, high-resolution imaging technique that is used to characterize atherosclerotic plaques. However, the identification of macrophages as important markers of inflammation and plaque vulnerability remains difficult. Here, we investigate whether the uptake of very small iron oxide particles (VSOP) in macrophages, that cluster in phagolysosomes and allow high-quality magnetic resonance imaging (MRI) of atherosclerotic plaques, and uptake of ferumoxytol nanoparticles enhance detection of macrophages by OCT. Read More
Clin Res Cardiol 2018 Dec 10. Epub 2018 Dec 10.
Med. Klinik und Poliklinik II-Herzzentrum Bonn, Universitätsklinikum Bonn, Bonn, Germany.
Aims: Percutaneous left atrial appendage occlusion (LAAo) is commonly performed under fluoroscopy including the use of contrast dye. In this study, we aimed to assess feasibility and safety of contrast-free, 3D-echo-based LAAo with the use of the AMPLATZER™ Amulet™ device.
Methods And Results: We analyzed 20 patients (74 ± 10 years, 65% males) at an increased thromboembolic and bleeding risk (CHADSVASC 4. Read More
Mol Ther 2018 Nov 1. Epub 2018 Nov 1.
Institut für Herz- und Kreislaufphysiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany. Electronic address:
Insulin-like growth factor 1 (IGF1) is an anabolic hormone that controls the growth and metabolism of many cell types. However, IGF1 also mediates cardio-protective effects after acute myocardial infarction (AMI), but the underlying mechanisms and cellular targets are not fully understood. Here we demonstrate that short-term IGF1 treatment for 3 days after AMI improved cardiac function after 1 and 4 weeks. Read More
Int J Cardiol 2018 Aug 27. Epub 2018 Aug 27.
Klinik für Innere Medizin, Schwerpunkt Kardiologie, DRK-Kliniken Berlin, Germany.
In the summer of 2016, delegates from the German Society of Cardiology (DGK), the German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) met in Cologne, Germany, to define consensus-based practice recommendations for the management of patients with pulmonary hypertension (PH). These recommendations were built on the 2015 European Pulmonary Hypertension guidelines, aiming at their practical implementation, considering country-specific issues, and including new evidence, where available. To this end, a number of working groups was initiated, one of which was specifically dedicated to PH associated with left heart disease. Read More
Vasa 2018 Dec 10:1-6. Epub 2018 Dec 10.
3 Herz-Jesu-Krankenhaus Dernbach, Dernbach, Germany.
Background: We sought to determine the patency and clinical symptom relief following the usage of the sinus-Obliquus venous stent in the endovascular treatment of venous obstruction of the ilio-femoral track in short-term.
Patients And Methods: 48 patients (62 % female, mean age 57 years) with chronic unilateral post-thrombotic obstruction (PTO) and non-thrombotic iliac vein obstructive lesions (NIVL) without involvement of inferior vena cava receiving a sinus-Obliquus venous stent was included in the analysis. Clinical improvement determined by the revised venous clinical severity score (rVCSS) as well as the clinical, etiologic, anatomic and pathophysiologic score (CEAP), safety, and stent patency rates were determined at baseline and at 1, 6 and 12 months after stent placement. Read More
Clin Res Cardiol 2018 Dec 5. Epub 2018 Dec 5.
Department of Electrophysiology, German Heart Center Munich, Munich, Germany.
Background: As there are limited data about the clinical practice of catheter ablation in asymptomatic children and adolescents with ventricular preexcitation on ECG, we performed the multicenter "CASPED" (Catheter ablation in ASymptomatic PEDiatric patients with Ventricular Preexcitation) study.
Methods And Results: In 182 consecutive children and adolescents aged between 8 and 18 years (mean age 12.9 ± 2. Read More
Herz 2018 Dec 5. Epub 2018 Dec 5.
Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, 100020, Beijing, China.
Background: Inflammation plays a key role in the progression of atrial fibrillation and its related prothrombotic state. The platelet-to-lymphocyte ratio (PLR) is an easily obtainable biomarker of inflammatory burden. Decreased left atrial appendage flow velocity (LAA-FV) reflects blood stasis, and left atrial strain is a manifestation of atrial remodeling. Read More
Cell Commun Signal 2018 Dec 5;16(1):96. Epub 2018 Dec 5.
Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich Heine University, Düsseldorf, Germany.
Background: Human pluripotent stem cells (PSCs) open new windows for basic research and regenerative medicine due to their remarkable properties, i.e. their ability to self-renew indefinitely and being pluripotent. Read More
Thorac Cardiovasc Surg 2018 11 3;66(8):608-621. Epub 2018 Dec 3.
Clinic for Cardiac, Thoracic and Vascular Surgery, Klinikum Braunschweig gGmbH, Braunschweig, Germany.
Based on a longtime voluntary registry, founded by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS), well-defined data of all cardiac, thoracic, and vascular surgery procedures performed in 78 German heart surgery departments during the year 2017 are analyzed. In 2017, a total of 179,337 procedures were submitted to the registry, and 101,728 were summarized as heart surgery procedures in the narrower sense. About 16. Read More
Dtsch Med Wochenschr 2018 Dec 3;143(24):1789-1790. Epub 2018 Dec 3.
Institut für Diagnostische und Interventionelle Radiologie, HELIOS Klinikum Krefeld.
Front Microbiol 2018 20;9:2711. Epub 2018 Nov 20.
Department of Soil Ecology, UFZ - Helmholtz-Centre for Environmental Research, Halle, Germany.
The rhizosphere encompasses the soil surrounding the surface of plants' fine roots. Accordingly, the microbiome present is influenced by both soil type and plant species. Furthermore, soil microbial communities respond to land-use intensity due to the effects on soil conditions and plant performance. Read More
Sci Rep 2018 Dec 4;8(1):17582. Epub 2018 Dec 4.
Institute of Physiology I, Life&Brain Center, Medical Faculty, University of Bonn, Bonn, Germany.
For the monitoring of vascular growth as well as adaptive or therapeutic (re)vascularization endothelial-specific reporter mouse models are valuable tools. However, currently available mouse models have limitations, because not all endothelial cells express the reporter in all developmental stages. We have generated PECAM/eGFP embryonic stem (ES) cell and mouse lines where the reporter gene labels PECAM endothelial cells and vessels with high specificity. Read More
Sci Data 2018 Dec 4;5:180281. Epub 2018 Dec 4.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Multiparametric Magnetic Resonance Imaging (mpMRI) is widely used for characterizing prostate cancer. Standard of care use of mpMRI in clinic relies on visual interpretation of the images by an expert. mpMRI is also increasingly used as a quantitative imaging biomarker of the disease. Read More
Lancet Neurol 2018 Dec 26;17(12):1109-1120. Epub 2018 Oct 26.
Klinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health, Berlin, Germany; German Centre for Cardiovascular Research, Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, Berlin, Germany; German Center for Neurodegenerative Disease, Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, Berlin, Germany. Electronic address:
Cardiac complications are a frequent medical problem during the first few days after an ischaemic stroke, and patients present with a broad range of symptoms including myocardial injury, cardiac dysfunction, and arrhythmia, with varying overlap between these three conditions. Evidence from clinical and neuroimaging studies and animal research suggests that these cardiac disturbances share the same underlying mechanisms. Although the exact cascade of events has yet to be elucidated, stroke-induced functional and structural alterations in the central autonomic network, with subsequent dysregulation of normal neural cardiac control, are the assumed pathophysiology. Read More
J Magn Reson 2018 Nov 13;298:16-22. Epub 2018 Nov 13.
High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; Department of Biomedical Magnetic Resonance, Eberhard-Karls University Tübingen, Tübingen, Germany.
Purpose: Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected CEST effects after injection are rather small in tissue especially at clinical field strengths (0.5-2%). Read More
Thorac Cardiovasc Surg 2018 Nov 28. Epub 2018 Nov 28.
Department of Cardiac Surgery, Heart Centre, University of Leipzig, Leipzig, Germany.
Background: Surgical treatment of infective aortic valve endocarditis (AVE) remains a therapeutic challenge, necessitating interdisciplinary approach to limit morbidity and mortality in this high-risk cohort. With a considerable spectrum of available laboratory testings, imaging techniques, as well as operative strategies developed in recent years, there is a lack of standardization across cardiac surgical departments in Germany. Thus, the optimal treatment strategy of AVE has yet to be defined. Read More
Med Klin Intensivmed Notfmed 2018 Nov 27. Epub 2018 Nov 27.
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Standort Berlin, Berlin, Deutschland.
About every fifth ischemic stroke is caused by atrial fibrillation. Oral anticoagulation is highly effective in secondary stroke prevention, but a relevant portion of patients with atrial fibrillation is not (permanently) anticoagulated for a variety of reasons. Based on present evidence, no general recommendation can be given for left atrial appendage occlusion in patients with nonvalvular atrial fibrillation. Read More
Herz 2018 Nov 27. Epub 2018 Nov 27.
Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, 1069 Xietu Road, 200032, Shanghai, China.
Background: The VOYAGER meta-analysis reported on the low-density lipoprotein cholesterol (LDL-C)-lowering effect of commonly used statins in Caucasian subjects. As there is limited literature available on the efficacy of statins in Asian populations, the current meta-analysis compared the effects of rosuvastatin and atorvastatin on LDL-C levels in an East Asian population.
Methods: The MEDLINE, PubMed, Embase, Cochrane Library, and Web of Science databases were searched for randomized controlled trials comparing lipid-lowering effects of rosuvastatin and atorvastatin in an East Asian population. Read More
Herz 2018 Nov 27. Epub 2018 Nov 27.
Department of Cardiology, Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, Zhejiang, China.
Objectives: The aim of this study is to investigate the sex-specific aortic root anatomy in patients with bicuspid aortic valve (BAV).
Patients And Methods: This retrospective study includes 73 consecutive patients with BAV who underwent CT evaluation before transcatheter aortic valve replacement (TAVR) between July 2013 and April 2017 in the Second Affiliated Hospital of Zhejiang University.
Result: The size of the annulus, diameter and height of the sinotubular junction (STJ), height of the coronary artery ostia, and dimension of the aorta were measured. Read More
Rev Esp Cardiol (Engl Ed) 2018 Oct 25. Epub 2018 Oct 25.
Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; Department of Cardiology, St.-Johannes-Hospital, Dortmund, Germany.
Introduction And Objectives: Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have been associated with adverse outcomes after transcatheter aortic valve implantation (TAVI). Experimental data have suggested a potential molecular interaction. Therefore, we assessed the association of Gal-3 and CA125 with prognosis after TAVI. Read More
Int J Cardiol 2018 Nov 17. Epub 2018 Nov 17.
Department of Cardiovascular Sciences, Cardiovascular Research Centre, NIHR Leicester Biomedical Research Centre University of Leicester, Leicester, United Kingdom. Electronic address:
Background: Aortic valve stenosis (AVS) and coronary artery disease (CAD) have a significant genetic contribution and commonly co-exist. To compare and contrast genetic determinants of the two diseases, we investigated associations of the LPA and 9p21 loci, i.e. Read More
Herz 2018 Nov 23. Epub 2018 Nov 23.
Cardiology Department, Numune Education and Research Hospital, 06100, Ankara, Turkey.
Background: Cardiac tamponade (CT) is characterized by compression of the cardiac chambers due to pericardial fluid accumulation. The etiology and prognosis may vary in different regions, and thus patient series from various regions can be useful for exploring the etiological and prognostic disparities. The aim of this study was to determine the clinical characteristics of patients with imminent CT, to evaluate the diagnostic performance of biochemical, microbiologic, and pathologic laboratory analysis, and to ascertain the prognosis of CT patients. Read More
Herz 2018 Nov 23. Epub 2018 Nov 23.
Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, the Second Hospital of Tianjin Medical University, at No. 23 Pingjiang Road, Hexi District, 300211, Tianjin, China.
Background: Atrial remodeling in the form of fibrosis is considered the basis in the development of atrial fibrillation (AF). The aim of this study was to investigate the effects of doxycycline on atrial remodeling induced by chronic intermittent hypoxia (CIH) and the mechanisms underlying such changes.
Methods: A total of 45 Sprague-Dawley rats were randomized into three groups: control group, CIH group, CIH with doxycycline treatment (CIH-D) group. Read More
Herz 2018 Nov 22. Epub 2018 Nov 22.
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Sichuan, China.
Introduction: The efficacy of liraglutide intervention for myocardial infarction (MI) remains controversial. We conducted a systematic review and meta-analysis to explore the influence of liraglutide intervention versus placebo on cardiac function for MI.
Methods: We searched PubMed, Embase, Web of science, EBSCO, and Cochrane library databases through April 2018 for randomized controlled trials (RCTs) assessing the effect of liraglutide intervention versus placebo on MI. Read More
JACC Clin Electrophysiol 2018 Nov 25;4(11):1440-1447. Epub 2018 Aug 25.
Centre Hospitalier Universitaire de Grenoble-Alpes, Grenoble, France.
Objectives: The CRYO4PERSISTENT AF (Cryoballoon Ablation for Early Persistent Atrial Fibrillation) trial aims to report long-term outcomes after a single pulmonary vein isolation (PVI)-only ablation procedure using the second-generation cryoballoon in persistent atrial fibrillation (PerAF) patients.
Background: Pulmonary vein isolation is recognized as the cornerstone of atrial fibrillation (AF) ablation, including ablation of PerAF.
Methods: The CRYO4PERSISTENT AF trial (NCT02213731) is a prospective, multicenter, single-arm trial designed to assess single-procedure outcomes of PVI using the cryoballoon. Read More
JACC Cardiovasc Interv 2018 Nov;11(22):2326-2334
Department of Innovative Interventions in Cardiology, University of Bonn, Bonn, Germany.
Objectives: This study sought to report the 1-year safety and efficacy outcomes in the FORWARD (CoreValve Evolut R FORWARD) study following transcatheter aortic valve replacement (TAVR) with the next-generation Evolut R device (Medtronic, Minneapolis, Minnesota) in routine clinical practice.
Background: The FORWARD study reported low incidences of mortality, disabling stroke, and significant paravalvular leak following TAVR in routine clinical practice at 30 days. Longer-term results in large patient populations with the Evolut R self-expanding, repositionable transcatheter heart valve (THV) are lacking. Read More
Neuroimage 2018 Nov 20. Epub 2018 Nov 20.
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.
Parkinson's disease causes a characteristic combination of motor symptoms due to progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta. The core impairment of dopaminergic neurotransmission has motivated the use of functional magnetic resonance imaging (fMRI) in patients with Parkinson's disease to elucidate the role of dopamine in motor control and cognition in humans. Here we review the main insights from functional brain imaging in Parkinson's disease. Read More
Thorac Cardiovasc Surg Rep 2018 Jan 20;7(1):e46. Epub 2018 Nov 20.
Klinik für Herz-, Kinderherz- und Gefäßchirurgie, Standort Gießen, Universitätsklinikum Gießen und Marburg GmbH, Gießen, Germany.
Eur Heart J 2018 Nov 21. Epub 2018 Nov 21.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
Aims: To investigate the clinical value of a lower blood pressure (BP) cut-off for Stage 1 (S1) hypertension (130-139 mmHg systolic or 80-89 mmHg diastolic) in comparison to the currently established Stage 2 (S2) cut-off (≥140/90 mmHg) in a population-based cohort.
Methods And Results: We assessed the hypertension prevalence and associated cardiovascular disease (CVD) events in a sample of 11 603 participants (52% men, 48% women; mean 47.6 years) from the MONICA/KORA prospective study. Read More
Clin Res Cardiol 2018 Nov 20. Epub 2018 Nov 20.
Klinik für Herz-und Kreislauferkrankungen, Abteilung Elektrophysiologie, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany.
Introduction: Patients with persistent atrial fibrillation (AF) may additionally suffer from a concealed sinus node disease. We sought to determine the incidence, indications and predictors of acute pacemaker [PM] implantation within 1 week after the ablation of persistent AF.
Methods And Results: We performed a retrospective analysis of patients, who had had an ablation of persistent AF at our center. Read More
Herz 2018 Dec;43(8):710-718
Institut für Geschlechterforschung in der Medizin (GiM) und Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115, Berlin, Deutschland.
Heart diseases are the most common cause of maternal death during pregnancy in Western countries. The current ESC guidelines 2018 for the management of cardiovascular diseases during pregnancy is a guide for any physician facing the challenge of caring for pregnant women with cardiovascular diseases. Among the new concepts compared to 2011, are recommendations to classify maternal risk due to the modified World Health Organization (mWHO) classification, introduction of the pregnancy heart team, guidance on assisted reproductive therapy, specific recommendations on anticoagulation for low-dose and high-dose requirements of vitamin K antagonists and the potential use of bromocriptine in peripartum cardiomyopathy. Read More
Herz 2018 Dec;43(8):689-694
Klinik für Herz- und Gefäßchirurgie, Universitäts-Herzzentrum Freiburg ∙ Bad Krozingen, Bad Krozingen, Deutschland.
The guidelines on myocardial revascularization published in 2018 are a joint initiative of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery. To establish indications for myocardial revascularization by percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), evidence of the functional relevance of coronary artery stenoses is needed either by non-invasive imaging function tests or intravascular hemodynamic measurements. The prognostic and symptomatic benefits of myocardial revascularization depend on whether complete revascularization can be achieved. Read More
Herz 2018 Dec;43(8):679-680
Praxisklinik Herz und Gefäße, Dresden, Deutschland.
Int J Cardiovasc Imaging 2018 Nov 19. Epub 2018 Nov 19.
Department of Cardiology, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Erlangen, Germany.
To evaluate diagnostic impact of clinical use of coronary computed tomography angiography (CCTA) in patients with suspected stable coronary artery disease (CAD) and its consequences in daily practice for patient management, depending on stress test results in daily practice. Between 2009 and 2014 of a total population of 1352 patients of the German Cardiac Computed Tomography (CT) Registry who had previously undergone stress tests, CCTA visualizations were carried out on the coronary arteries with suspected stable CAD. Patients were divided into three groups according to stress test results: Group 1 with inconclusive (n = 178, 13. Read More
J Neurol 2018 Nov 16. Epub 2018 Nov 16.
Department of Neurology and Institute for Translational Neurology, University Hospital Muenster, University of Muenster, Albert-Schweitzer-Campus 1, 48149, Muenster, Germany.
Background: Natalizumab (NTZ) was the first approved monoclonal antibody for the treatment of relapsing-remitting multiple sclerosis (RRMS). Despite proven and sustained efficacy, its use is limited by the risk of progressive multifocal leukoencephalopathy (PML). Moreover, some patients show ongoing disease activity under NTZ, requiring a switch to another disease-modifying treatment (DMT). Read More
Dtsch Med Wochenschr 2018 Nov 15;143(23):e206-e212. Epub 2018 Nov 15.
Universitäts-Herzzentrum Freiburg, Abteilung für Kardiologie und Angiologie I, Medizinische Fakultät, Universität Freiburg, Deutschland.
Introduction: Treatment of aortic valve stenosis has been changing since the introduction of transcatheter aortic valve replacement (TAVR). The present study investigates the treatment of aortic valve stenosis in a real-world population 2014 and 2015 in Germany.
Methods: Patient characteristics and in-hospital outcomes of all 38 414 isolated surgical aortic valve replacements (SAVR) or TAVR were analyzed. Read More
Magn Reson Med 2018 Nov 15. Epub 2018 Nov 15.
High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany.
Purpose: For clinical implementation, a chemical exchange saturation transfer (CEST) imaging sequence must be fast, with high signal-to-noise ratio (SNR), 3D coverage, and produce robust contrast. However, spectrally selective CEST contrast requires dense sampling of the Z-spectrum, which increases scan duration. This article proposes a compromise: using a 3D snapshot gradient echo (GRE) readout with optimized CEST presaturation, sampling, and postprocessing, highly resolved Z-spectroscopy at 3T is made possible with 3D coverage at almost no extra time cost. Read More
Ann Noninvasive Electrocardiol 2018 Nov 14:e12617. Epub 2018 Nov 14.
Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich (TUM), Munich, Germany.
Background: The electrocardiographic early repolarization (ER) pattern is associated with idiopathic ventricular fibrillation and increased long-term cardiovascular mortality. Whether structural cardiac aberrations influence the phenotype is unclear. Since ER is particularly common in athletes, we evaluated its prevalence and investigated predisposing echocardiographic characteristics and cardiopulmonary exercise capacity in a cohort of elite athletes. Read More
J Phys Chem Lett 2018 Nov 20:6853-6863. Epub 2018 Nov 20.
Department of Physics , University of Oxford , Clarendon Laboratory, Parks Road , Oxford OX1 3PU , U.K.
Metal-halide perovskites have emerged as highly promising semiconductors with excellent optoelectronic properties. This Perspective outlines how the dynamic response of the ionic lattice affects key electronic properties such as exciton binding energies and charge-carrier mobilities in hybrid perovskites. Such links are shown to derive from the frequency-dependence of the dielectric function, which is governed by contributions from electronic interband transitions, polar vibrations of the metal-halide sublattice, organic cation collective reorientations, and ionic movement. Read More
J Mol Cell Cardiol 2018 Dec 7;125:205. Epub 2018 Nov 7.
Klinik für Kardiologie und Angiologie, Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover, 30625 Hannover, Germany; Abteilung für Herz- und Kreislaufforschung, European Center for Angioscience (ECAS), Medizinische Fakultät Mannheim der Universität Heidelberg, 68167 Mannheim,Germany. Electronic address:
Echocardiography 2018 Dec 8;35(12):1947-1955. Epub 2018 Nov 8.
Clinic for Cardiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Objective: We investigated physiological systolic left ventricular (LV) myocardial mechanics and gradients to provide a database for later studies of diseased hearts.
Methods: The analyses were performed in 131 heart-healthy individuals and included seven parameters of myocardial mechanics using speckle tracking echocardiography (STE).
Results: Basal to apical and circumferentially significant physiological intraventricular parameter gradients of myocardial activity were determined. Read More
eNeuro 2018 Sep-Oct;5(5). Epub 2018 Oct 15.
Institute of Neuroanatomy, University Medical Center, Hamburg 20246, Germany.
HCN1 compartmentalization in CA1 pyramidal cells, essential for hippocampal information processing, is believed to be controlled by the extracellular matrix protein Reelin. Expression of Reelin, in turn, is stimulated by 17β-estradiol (E2). In this study, we therefore tested whether E2 regulates the compartmentalization of HCN1 in CA1 via Reelin. Read More
Nutrients 2018 Nov 2;10(11). Epub 2018 Nov 2.
Molecular Preventive Medicine, Institute for Infection Prevention and Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, 79106 Freiburg, Germany.
The present human intervention trial investigated the health-promoting potential of with a focus on effects of thermal processing on bioactivity. Twenty-two healthy subjects consumed a preparation from raw (allyl isothiocyanate-containing) or cooked (no allyl isothiocyanate) leaves for five days in a randomized crossover design. Peripheral blood mononuclear cells were exposed to aflatoxin B1 (AFB1), with or without metabolic activation using human S9 mix, and subsequently analyzed for DNA damage using the comet assay. Read More
J Interv Cardiol 2018 Dec 5;31(6):916-924. Epub 2018 Nov 5.
Institut für Herz- und Kreislaufforschung am Klinikum Links der Weser Bremen (BIHKF), Bremen, Germany.
Aims: To evaluate the impact of right ventricular dysfunction (RVD) on outcome after transcatheter mitral valve repair (TMVR) in patients with chronic heart failure (CHF) and severe functional mitral regurgitation (FMR).
Methods And Results: One hundred thirty patients (median age 72.7 ± 10. Read More