8,836 results match your criteria Herz KardiovaskulA¤re Erkrankungen[Journal]


Exploring the science, safety, and benefits of air care products: perspectives from the inaugural air care summit.

Inhal Toxicol 2019 Apr 18:1-13. Epub 2019 Apr 18.

q Drug and Poison Information Center , Cincinnati Children's Hospital , Cincinnati , OH , USA.

Seventy-one percent of US households purchase air care products. Air care products span a diverse range of forms, including scented aerosol sprays, pump sprays, diffusers, gels, candles, and plug-ins. These products are used to eliminate indoor malodors and to provide pleasant scent experiences. Read More

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http://dx.doi.org/10.1080/08958378.2019.1597221DOI Listing

Erratum zu: Warum brauchen wir Cardiac-Arrest-Zentren?

Herz 2019 Apr 16. Epub 2019 Apr 16.

Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln (AöR), Kerpener Straße 62, 50937, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00059-019-4804-9DOI Listing

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2019 Apr 16. Epub 2019 Apr 16.

Berlin-Brandenburg Center for Regenerative Therapies, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) Berlin, Department of Cardiology, Campus Virchow Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany.

Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. Read More

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http://dx.doi.org/10.1002/ejhf.1461DOI Listing
April 2019
6.526 Impact Factor

[63-year-old male with nodule in the left upper lobe : Preparation for the medical specialist examination: Part 20].

Authors:
T Kammerer

Anaesthesist 2019 Apr;68(Suppl 2):170-174

Institut für Anästhesiologie und Schmerztherapie, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Georgstr. 11, 32545, Bad Oeynhausen, Deutschland.

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http://dx.doi.org/10.1007/s00101-019-0568-0DOI Listing

Pleasant olfactory cues can reduce cigarette craving.

J Abnorm Psychol 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychology.

Cigarette craving is a cardinal feature of smoking, which is the leading preventable cause of death. Despite its clinical relevance, there remains a pressing need to develop new approaches for controlling craving. Although olfactory cues (OCs) are especially well suited to reduce affectively charged cravings, there has been surprisingly little research on the topic. Read More

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http://dx.doi.org/10.1037/abn0000431DOI Listing

Deep learning outperformed 136 of 157 dermatologists in a head-to-head dermoscopic melanoma image classification task.

Eur J Cancer 2019 Apr 10;113:47-54. Epub 2019 Apr 10.

National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

Background: Recent studies have successfully demonstrated the use of deep-learning algorithms for dermatologist-level classification of suspicious lesions by the use of excessive proprietary image databases and limited numbers of dermatologists. For the first time, the performance of a deep-learning algorithm trained by open-source images exclusively is compared to a large number of dermatologists covering all levels within the clinical hierarchy.

Methods: We used methods from enhanced deep learning to train a convolutional neural network (CNN) with 12,378 open-source dermoscopic images. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.04.001DOI Listing

Heart Transplantation in Systemic Sclerosis: New Impulses for Conventional Scleroderma Transplantation Regimen and Scleroderma Diagnostic Monitoring: 2 Case Reports.

Transplant Proc 2019 Apr 9;51(3):865-870. Epub 2019 Jan 9.

Institute for Laboratory and Transfusion Medicine, Herz- und Diabeteszentrum Nordrhein-Westfalen, Ruhr University Bochum, Bad Oeynhausen, Germany.

Background: Although low (but increasing) rates of lung/lung-heart transplantations of scleroderma (systemic sclerosis [SSc]) patients have been reported, exclusive heart transplantation is a rare approach for treatment of heart failure due to SSc.

Cases: We report on 2 cases of SSc patients receiving a heart transplantation (HTx) due to severe and progressive right heart failure without pulmonary artery hypertension. One patient received a hepatitis C virus (HCV)-positive donor heart and recovered excellently from viral transmission after administration of a direct-acting antiviral (DAA) regimen. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.025DOI Listing

Role of percutaneous edge-to-edge repair in secondary mitral regurgitation after MITRA-FR and COAPT : A comment by the section of AV-valve treatment of the Working Group of Interventional Cardiology (AGIK) of the German Society of Cardiology (DGK).

Clin Res Cardiol 2019 Apr 8. Epub 2019 Apr 8.

Klinik für Allgemeine und Interventionelle Kardiologie/Angiologie, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bochum, Germany.

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http://dx.doi.org/10.1007/s00392-019-01457-3DOI Listing
April 2019
1 Read

A closer look at right ventricular 3D volume quantification by transthoracic echocardiography and cardiac MRI.

Clin Radiol 2019 Apr 4. Epub 2019 Apr 4.

Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg, Germany.

Aim: To compare right ventricular (RV) volumetry using state-of-the-art three-dimensional (3D) transthoracic echocardiography (3DE) and cardiac magnetic resonance imaging (CMR) near-simultaneously in a clinical setting.

Materials And Methods: Forty-seven consecutive patients received comprehensive echocardiography including 3DE within 30 minutes of CMR. RV volumetry was performed offline with semi-automated 3D endocardial border tracing as well as manual delineation of the compacted myocardium in short-axis views by CMR. Read More

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http://dx.doi.org/10.1016/j.crad.2019.03.005DOI Listing

Procedural success, safety and patients satisfaction after second ablation of atrial fibrillation in the elderly: results from the German Ablation Registry.

Clin Res Cardiol 2019 Apr 5. Epub 2019 Apr 5.

Department of Cardiology, Asklepios Klinik St. Georg, Lohmühlenstr. 5, 20099, Hamburg, Germany.

Background: Aged patients are underrepresented in clinical trials on catheter ablation of atrial fibrillation (AF). In addition, results of outcomes after repeat ablation in the elderly are lacking. We report the results of first repeat AF ablation procedures of aged patients from a real-world multicenter prospective registry. Read More

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http://dx.doi.org/10.1007/s00392-019-01471-5DOI Listing
April 2019
1 Read

Aromaticity and Antiaromaticity in the Excited States of Porphyrin Nanorings.

J Phys Chem Lett 2019 Apr 10;10(8):2017-2022. Epub 2019 Apr 10.

Department of Chemistry, Chemistry Research Laboratory , University of Oxford , Oxford OX1 3TA , United Kingdom.

Aromaticity can be a useful concept for predicting the behavior of excited states. Here we show that π-conjugated porphyrin nanorings exhibit size-dependent excited-state global aromaticity and antiaromaticity for rings containing up to eight porphyrin subunits, although they have no significant global aromaticity in their neutral singlet ground states. Applying Baird's rule, even rings ([4 n] π-electrons) are aromatic in their lowest excited states, whereas the lowest excited states of odd rings ([4 n + 2] π-electrons) are antiaromatic. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b00623DOI Listing

Alterations of protein expression of phospholamban, ZASP and plakoglobin in human atria in subgroups of seniors.

Sci Rep 2019 Apr 4;9(1):5610. Epub 2019 Apr 4.

Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, 06097, Halle/Saale, Germany.

The mature mammalian myocardium contains composite junctions (areae compositae) that comprise proteins of adherens junctions as well as desmosomes. Mutations or deficiency of many of these proteins are linked to heart failure and/or arrhythmogenic cardiomyopathy in patients. We firstly wanted to address the question whether the expression of these proteins shows an age-dependent alteration in the atrium of the human heart. Read More

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http://www.nature.com/articles/s41598-019-42141-w
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http://dx.doi.org/10.1038/s41598-019-42141-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449388PMC
April 2019
1 Read

Lipoprotein(a).

Authors:
K P Mellwig A Vogt

Clin Res Cardiol Suppl 2019 Apr;14(Suppl 1):1-4

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstr. 1, 80336, Munich, Germany.

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http://dx.doi.org/10.1007/s11789-019-00100-9DOI Listing

Cardiac imaging after ischemic stroke : Echocardiography, CT, or MRI?

Herz 2019 Apr 2. Epub 2019 Apr 2.

Department of General and Interventional Cardiology, Building O70, University Heart Center Hamburg, Martinistraße 52, 20246, Hamburg, Germany.

About 20-25% of all ischemic strokes are of cardioembolic etiology, with atrial fibrillation and heart failure as the most common underlying pathologies. Diagnostic work-up by noninvasive cardiac imaging is essential since it may lead to changes in therapy, e.g. Read More

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http://dx.doi.org/10.1007/s00059-019-4803-xDOI Listing
April 2019
2 Reads

[Management of oral anticoagulation related intracerebral hemorrhage].

Herz 2019 Apr 2. Epub 2019 Apr 2.

Klinik für Neurologie, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland.

The incidence of intracerebral hemorrhage (ICH) in patients using oral anticoagulation (OAC) will continue to increase with the demographic change of an aging population. As compared to primary spontaneous ICH, OAC-ICH is characterized by larger hematoma volumes, more frequent hematoma enlargement and intraventricular hemorrhage resulting in an even worse prognosis. Specific treatment should focus on immediate reversal of anticoagulation in addition to the basic acute management of ICH. Read More

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http://link.springer.com/10.1007/s00059-019-4802-y
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http://dx.doi.org/10.1007/s00059-019-4802-yDOI Listing
April 2019
1 Read

[New aspects of thrombolysis and thrombectomy in pulmonary embolism].

Herz 2019 Apr 2. Epub 2019 Apr 2.

Kardiologie und Angiologie I, Universitäts-Herzzentrum Freiburg - Bad Krozingen, Hugstetter Str. 55, 79106, Freiburg, Deutschland.

Pulmonary embolism is a potentially life-threatening disease, which can present with varying severity. Based on an emergency risk stratification, the initial treatment strategy should be chosen without delay. While patients with a low mortality risk can be treated in an outpatient setting, patients at high risk should proceed to immediate recanalization by thrombolysis or thrombectomy. Read More

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http://link.springer.com/10.1007/s00059-019-4801-z
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http://dx.doi.org/10.1007/s00059-019-4801-zDOI Listing
April 2019
5 Reads

[Closure of the patent foramen ovale (PFO) in cryptogenic stroke].

Authors:
H-C Diener F Knebel

Herz 2019 Apr 2. Epub 2019 Apr 2.

Medizinische Klinik m. S. Kardiologie und Angiologie, Campus Mitte, Charité Universitätsmedizin Berlin, 10098, Berlin, Deutschland.

Autopsy studies and echocardiographic investigations have shown that around 20-25% of the healthy population have a patent foramen ovale (PFO). In patients younger than 55 years the risk of a cryptogenic stroke is increased in the presence of a PFO. The first three randomized studies could not demonstrate superiority of an interventional closure of a PFO compared to antithrombotic treatment in patients with cryptogenic stroke. Read More

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http://dx.doi.org/10.1007/s00059-019-4800-0DOI Listing
April 2019
5 Reads

Therapeutic Targeting of High Mobility Group Box-1 in Pulmonary Arterial Hypertension.

Am J Respir Crit Care Med 2019 Apr 2. Epub 2019 Apr 2.

Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael´s, Dept. of Surgery, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1164/rccm.201808-1597LEDOI Listing

Environmental noise induces the release of stress hormones and inflammatory signaling molecules leading to oxidative stress and vascular dysfunction-Signatures of the internal exposome.

Biofactors 2019 Apr 2. Epub 2019 Apr 2.

Department of Cardiology 1, Center for Cardiology, Mainz, Germany.

Environmental noise is a well-recognized health risk and part of the external exposome-the World Health Organization estimates that 1 million healthy life years are lost annually in Western Europe alone due to noise-related complications, including increased incidence of hypertension, heart failure, myocardial infarction, and stroke. Previous data suggest that noise works through two paired pathways in a proposed reaction model for noise exposure. As a nonspecific stressor, chronic low-level noise exposure can cause a disruption of sleep and communication leading to annoyance and subsequent sympathetic and endocrine stress responses leading to increased blood pressure, heart rate, stress hormone levels, and in particular more oxidative stress, being responsible for vascular dysfunction and representing changes of the internal exposome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/biof.1506
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http://dx.doi.org/10.1002/biof.1506DOI Listing
April 2019
3 Reads

Attenuation of ST-segment elevation after ischemic conditioning maneuvers reflects cardioprotection online.

Basic Res Cardiol 2019 04 1;114(3):22. Epub 2019 Apr 1.

Institut für Pathophysiologie, Westdeutsches Herz- und Gefäßzentrum, Universitätsklinikum Essen, Hufelandstr. 55, 45122, Essen, Germany.

Ischemic conditioning maneuvers, when induced either locally in the heart or remotely from the heart, reduce infarct size. However, infarct size reduction can be assessed no earlier than hours after established reperfusion. ST-segment elevation and its attenuation might reflect cardioprotection by ischemic conditioning online. Read More

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http://dx.doi.org/10.1007/s00395-019-0732-3DOI Listing

Fabry disease: Detection of Alu-mediated exon duplication by NGS.

Mol Cell Probes 2019 Mar 29. Epub 2019 Mar 29.

Clinic for General and Interventional Cardiology/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

Monogenetic diseases can be analyzed routinely by targeted DNA sequencing. If causative variants are not found, complementary methods like RNA sequencing or analysis of copy number variations by multiplex ligation-dependent probe amplification have to be considered. In the latter, especially exonic duplications or deletions can be detected, but the precise sites of mutations remain unclear. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.03.008DOI Listing
March 2019
1 Read

Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy.

J Clin Med 2019 Mar 27;8(4). Epub 2019 Mar 27.

Department of Internal Medicine and Cardiology, Charité-University-Medicine Berlin, Campus Virchow Klinikum (CVK), 13353 Berlin, Germany.

We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as the cancer group. All participants underwent comprehensive echocardiographic examination before the start of chemo- or radiotherapy. Read More

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http://dx.doi.org/10.3390/jcm8040421DOI Listing
March 2019
1 Read

Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T.

Magn Reson Med 2019 Mar 29. Epub 2019 Mar 29.

Division of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.

Purpose: Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27751
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http://dx.doi.org/10.1002/mrm.27751DOI Listing
March 2019
11 Reads

Evolthon: A community endeavor to evolve lab evolution.

PLoS Biol 2019 Mar 29;17(3):e3000182. Epub 2019 Mar 29.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Should one apply chemical mutagenesis, and do strains with high innate mutation rate evolve faster? What are ideal population sizes of evolving populations? There are endless strategies, beyond those that can be exposed by individual labs. We therefore arranged a community challenge, Evolthon, in which students and scientists from different labs were asked to evolve Escherichia coli or Saccharomyces cerevisiae for an abiotic stress-low temperature. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440615PMC

Effectiveness of the Pulsar-18 self-expanding stent with optional drug-coated balloon angioplasty in the treatment of femoropopliteal lesions - the BIOFLEX PEACE All-Comers Registry.

Vasa 2019 Mar 29:1-8. Epub 2019 Mar 29.

9 Radiology Clinic, Evangelisches Krankenhaus Mülheim, Mülheim an der Ruhr, Germany.

Background: Previous studies showed favorable results after treatment of femoropopliteal lesions with the Pulsar-18 self-expanding (SE) nitinol stent. The objective of this registry was to evaluate whether these results will be confirmed in a real-world setting with varying stenting strategies.

Patients And Methods: In this prospective, observational trial, 160 patients with 186 femoropopliteal lesions were treated with the Pulsar-18 SE nitinol stent at 9 German sites. Read More

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http://dx.doi.org/10.1024/0301-1526/a000785DOI Listing
March 2019
2 Reads
1.213 Impact Factor

Exercise training in patients with a left ventricular assist device (Ex-VAD): rationale and design of a multicentre, prospective, assessor-blinded, randomized, controlled trial.

Eur J Heart Fail 2019 Mar 28. Epub 2019 Mar 28.

Department of Internal Medicine and Cardiology, Charité University Medicine Berlin, Berlin, Germany.

Aims: Left ventricular assist device (LVAD) therapy is a promising option for patients with advanced heart failure (HF), refractory to guideline-mandated medical treatment either as a bridge to heart transplantation or as lifelong therapy. Functional capacity improves after LVAD implantation but remains reduced in patients with long-term LVAD therapy. Exercise training (ET) improves functional capacity and quality of life (QoL) in HF and may provide incremental benefits in patients supported with LVAD therapy. Read More

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http://dx.doi.org/10.1002/ejhf.1431DOI Listing
March 2019
1 Read

[Immunization as Treatment for arteriosclerosis-a realistic vision?]

Authors:
H Winkels S Baldus

Herz 2019 Apr;44(2):93-95

Herzzentrum, Abt. f. Kardiologie, Universität Köln, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00059-019-4793-8DOI Listing

Outcomes of Patients after Implantation of the Pericardial All-Biological Valve No-React Aortic Conduit (BioIntegral) for Root Replacement in Complex Surgical Procedures.

Thorac Cardiovasc Surg 2019 Mar 28. Epub 2019 Mar 28.

Klinik für Herz- und Gefäßchirurgie, Universitatsklinikum Schleswig-Holstein Campus Kiel, Kiel, Germany.

Objective:  Therapy of complex aortic root pathologies remains a great surgical challenge. Though different graft materials are available to replace the often-destroyed aortic root, long durability and freedom from reoperation of the latter are still under debate. The aim of our study was to investigate patients' postoperative outcome after implantation of the BioIntegral conduit in complex aortic root pathologies. Read More

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http://dx.doi.org/10.1055/s-0039-1683425DOI Listing
March 2019
1 Read
1.075 Impact Factor

Retinal stem cells modulate proliferative parameters to coordinate post-embryonic morphogenesis in the eye of fish.

Elife 2019 Mar 26;8. Epub 2019 Mar 26.

Centre for Organismal Studies, Heidelberg University, Heidelberg, Germany.

Combining clonal analysis with a computational agent based model, we investigate how tissue-specific stem cells for neural retina (NR) and retinal pigmented epithelium (RPE) of the teleost medaka () coordinate their growth rates. NR cell division timing is less variable, consistent with an upstream role as growth inducer. RPE cells divide with greater variability, consistent with a downstream role responding to inductive signals. Read More

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http://dx.doi.org/10.7554/eLife.42646DOI Listing

How β-Phase Content Moderates Chain Conjugation and Energy Transfer in Polyfluorene Films.

J Phys Chem Lett 2019 Apr 29;10(8):1729-1736. Epub 2019 Mar 29.

Department of Physics , University of Oxford, Clarendon Laboratory , Parks Road , Oxford OX1 3PU , United Kingdom.

Poly(9,9-dioctylfluorene) (PFO) is a blue-light-emitting polymer exhibiting two distinct phases, namely, the disordered "glassy" phase and a more ordered β-phase. We investigate how a systematic increase in the fraction of β-phase present in PFO films controls chain conformation, photoluminescence quantum efficiency (PLQE), and the resonant energy transfer from the glassy to the β-phase. All films are prepared by the same technique, using paraffin oil as an additive to the spin-coating solution, allowing systematic tuning of the β-phase fraction. Read More

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http://dx.doi.org/10.1021/acs.jpclett.9b00483DOI Listing

Mechanical circulatory support with Impella versus intra-aortic balloon pump or medical treatment in cardiogenic shock-a critical appraisal of current data.

Clin Res Cardiol 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, Charité-Universitaetsmedizin Berlin, Berlin, Germany.

Aims: Patients suffering from cardiogenic shock (CS) have a high mortality and morbidity. The Impella percutaneous left-ventricular assist device (LVAD) decreases LV preload, increases cardiac output, and improves coronary blood flow. We aimed to review and meta-analyze available data comparing Impella versus intra-aortic pump (IABP) counterpulsation or medical treatment in CS due to acute myocardial infarction or post-cardiac arrest. Read More

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http://dx.doi.org/10.1007/s00392-019-01458-2DOI Listing
March 2019
1 Read

Congestive heart failure caused by silent ischemia and silent myocardial infarction : Diagnostic challenge in type 2 diabetes.

Authors:
P Valensi C Meune

Herz 2019 Mar 21. Epub 2019 Mar 21.

Department of Cardiology, Avicenne Hospital, Inserm UMR-942, Paris Nord University, Bobigny, France.

In asymptomatic patients with type 2 diabetes (T2D), the prevalence of silent myocardial infarction on routine electrocardiograms is about 4% while for silent myocardial ischemia it is 20-30%. Some studies showed that silent myocardial infarction is associated with an increased risk of incident heart failure (HF), whereas no prospective study has ever reported such a risk in patients with silent myocardial ischemia. In patients with HF, however, previously unrecognized coronary artery disease (CAD) often seems to be involved. Read More

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http://dx.doi.org/10.1007/s00059-019-4798-3DOI Listing

Exosomes for Cardioprotection: Are We Ready for Clinical Translation?

Eur Heart J 2019 Mar;40(12):953-956

Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz106DOI Listing
March 2019
1 Read

Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure.

Front Cardiovasc Med 2019 6;6:20. Epub 2019 Mar 6.

Center for Cardiology, Cardiology I, Translational Vascular Biology, University Medical Center Mainz, Mainz, Germany.

Endothelial cells are, by number, one of the most abundant cell types in the heart and active players in cardiac physiology and pathology. Coronary angiogenesis plays a vital role in maintaining cardiac vascularization and perfusion during physiological and pathological hypertrophy. On the other hand, a reduction in cardiac capillary density with subsequent tissue hypoxia, cell death and interstitial fibrosis contributes to the development of contractile dysfunction and heart failure, as suggested by clinical as well as experimental evidence. Read More

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http://dx.doi.org/10.3389/fcvm.2019.00020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415587PMC
March 2019
1 Read

Animal models of arrhythmia: classic electrophysiology to genetically modified large animals.

Nat Rev Cardiol 2019 Mar 20. Epub 2019 Mar 20.

Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany.

Arrhythmias are common and contribute substantially to cardiovascular morbidity and mortality. The underlying pathophysiology of arrhythmias is complex and remains incompletely understood, which explains why mostly only symptomatic therapy is available. The evaluation of the complex interplay between various cell types in the heart, including cardiomyocytes from the conduction system and the working myocardium, fibroblasts and cardiac immune cells, remains a major challenge in arrhythmia research because it can be investigated only in vivo. Read More

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http://dx.doi.org/10.1038/s41569-019-0179-0DOI Listing

Surface Design of Enantiomeric HPLC Separation on Vancomycin and Teicoplanin-Based Stationary Phases, a Tool for Chiral Recognition of Model β-Blockers.

J Chromatogr Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Pharmaceutical Chemistry, German University in Cairo, 11835, Cairo, Egypt.

A quality-by-design approach was adopted for enantioseparation of atenolol on Vancomycin and Teicoplanin-based chiral stationary phases using reversed phase (RP) mode and polar ionic mode (PIM), respectively to account for major forces involved in enantiorecognition of β-blockers on macrocyclics. A fractional factorial screening design for the two modes; followed by a central composite optimization design and regression analysis were able to point out critical factors and chromatographic responses and robust surface of the design. Within the studied range of flow the optimal was 0. Read More

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https://academic.oup.com/chromsci/advance-article/doi/10.109
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http://dx.doi.org/10.1093/chromsci/bmz018DOI Listing
March 2019
2 Reads

Optimization of the alkaline comet assay for easy repair capacity quantification of oxidative DNA damage in PBMC from human volunteers using aphidicolin block.

DNA Repair (Amst) 2019 May 14;77:58-64. Epub 2019 Mar 14.

Molecular Preventive Medicine, University Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Straße 115b, 79106 Freiburg im Breisgau, Germany. Electronic address:

Assessment of DNA repair capacity (DRC) upon ex vivo challenge of peripheral blood mononuclear cells (PBMC) with oxidative damage inducing agents, as evaluated by the comet assay, is widely used as biomarker to assess the antioxidant status in human studies. Here, the alkaline comet assay was now optimized for easy and time saving detection of repair capacity upon oxidative stress-induced DNA damage using the DNA polymerase inhibitor aphidicolin (APC) to block repair of hydrogen peroxide (HO) induced DNA damage. Addition of a DMSO-containing DNA damage stop solution was found suitable to replace washing steps for HO removal before APC block. Read More

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http://dx.doi.org/10.1016/j.dnarep.2019.03.005DOI Listing

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial.

JAMA 2019 Mar 15. Epub 2019 Mar 15.

Duke Clinical Research Institute, Duke University, Durham, North Carolina.

Importance: Catheter ablation is effective in restoring sinus rhythm in atrial fibrillation (AF), but its effects on long-term mortality and stroke risk are uncertain.

Objective: To determine whether catheter ablation is more effective than conventional medical therapy for improving outcomes in AF.

Design, Setting, And Participants: The Catheter Ablation vs Antiarrhythmic Drug Therapy for Atrial Fibrillation trial is an investigator-initiated, open-label, multicenter, randomized trial involving 126 centers in 10 countries. Read More

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http://dx.doi.org/10.1001/jama.2019.0693DOI Listing
March 2019
7 Reads

[Immunity and inflammation in atherosclerosis].

Authors:
D Wolf K Ley

Herz 2019 Apr;44(2):107-120

Division of Inflammation Biology, La Jolla Institute for Immunology, 9420 Athena Cir, 92037, La Jolla, CA, USA.

There is now overwhelming experimental and clinical evidence that arteriosclerosis is a chronic inflammatory disease. Lessons learned from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice models and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb arteriosclerosis. This article summarizes and discusses the pathogenesis of arteriosclerosis with a focus on the role of the adaptive immune system. Read More

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http://dx.doi.org/10.1007/s00059-019-4790-yDOI Listing

[Patent foramen ovale with a license to kill].

Authors:
B Meier

Med Klin Intensivmed Notfmed 2019 Mar 11. Epub 2019 Mar 11.

Universitätsklinik für Kardiologie, Departement Herz und Gefässe, Inselspital, 3010, Bern, Schweiz.

A patent foramen ovale (PFO) is present in about one of four, and one of its dangerous forms (large or associated with atrial septal aneurysm, Eustachian valve, or Chiari network) in one of twenty people. About 140 years ago, the PFO was shown to have the potential to result in death due to stroke and also myocardial infarction. The described decrease of the prevalence of a PFO with age may be a consequence of this. Read More

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http://dx.doi.org/10.1007/s00063-019-0561-zDOI Listing
March 2019
1 Read

Dexamethasone as an adjuvant for peripheral nerve blockade: a randomised, triple-blinded crossover study in volunteers.

Br J Anaesth 2019 Apr 31;122(4):525-531. Epub 2019 Jan 31.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Background: The efficacy of dexamethasone in extending the duration of local anaesthetic block is uncertain. In a randomised controlled triple blind crossover study in volunteers, we tested the hypothesis that neither i.v. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193001
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http://dx.doi.org/10.1016/j.bja.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435911PMC
April 2019
5 Reads

Anxiety, depression and quality of life in acute high risk cardiac disease patients eligible for wearable cardioverter defibrillator: Results from the prospective multicenter CRED-registry.

PLoS One 2019 11;14(3):e0213261. Epub 2019 Mar 11.

Department III of Internal Medicine, Heart Center, University of Cologne, Cologne, Germany.

Background: Psychological distress is common in patients with cardiovascular disease and negatively impacts outcome.

Hypothesis: Psychological distress is high in acute high risk cardiac patients eligible for a WCD, and associated with low quality of life. Distress is aggravated by WCD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213261PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411111PMC
March 2019
3.234 Impact Factor

First description of a compensatory xylosyltransferase I induction observed after an antifibrotic UDP-treatment of normal human dermal fibroblasts.

Biochem Biophys Res Commun 2019 Apr 8;512(1):7-13. Epub 2019 Mar 8.

Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Georgstrasse 11, 32545, Bad Oeynhausen, Germany.

Fibrosis is a serious health problem often leading to accompanying organ failure. During the manifestation of the disease, an accumulation of different extracellular matrix (ECM) molecules, such as proteoglycans, takes place. There is no appropriate therapeutic option available to heal fibrosis to date. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.150DOI Listing
April 2019
5 Reads

A convolutional neural network trained with dermoscopic images performed on par with 145 dermatologists in a clinical melanoma image classification task.

Eur J Cancer 2019 Apr 8;111:148-154. Epub 2019 Mar 8.

National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany.

Background: Recent studies have demonstrated the use of convolutional neural networks (CNNs) to classify images of melanoma with accuracies comparable to those achieved by board-certified dermatologists. However, the performance of a CNN exclusively trained with dermoscopic images in a clinical image classification task in direct competition with a large number of dermatologists has not been measured to date. This study compares the performance of a convolutional neuronal network trained with dermoscopic images exclusively for identifying melanoma in clinical photographs with the manual grading of the same images by dermatologists. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.02.005DOI Listing

[Curing cancer and protecting the heart : Challenges in cardio-oncology in the era of modern tumor treatment].

Herz 2019 Apr;44(2):175-188

Klinik III für Innere Medizin, Herzzentrum, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Recent advances in the medical oncological treatment options for cancer have led to a clear improvement in the survival rate worldwide; however, many of the recently developed new drugs are directly or indirectly associated with cardiovascular side effects. Cardiovascular diseases are already the most frequent non-cancerous cause of death in tumor patients. Prevention, early detection of these complications, correct management and timely initiation of specific cardiac medical treatment are the key for an improvement of the cardiovascular prognosis. Read More

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http://dx.doi.org/10.1007/s00059-019-4787-6DOI Listing

Key inflammatory pathways underlying vascular remodeling in pulmonary hypertension.

Herz 2019 Apr;44(2):130-137

Klinik III für Innere Medizin, Herzzentrum, Universität zu Köln, Kerpener Str. 62, 50937, Cologne, Germany.

Independent of the underlying cause, pulmonary hypertension (PH) remains a devastating condition that is characterized by limited survival. Cumulating evidence indicates that in addition to a dysbalance of mediators regulating vascular tone and growth factors promoting vascular remodeling, failure to resolve inflammation and altered immune processes play a pivotal role in the development and progression of PH. Here, we highlight the role of key inflammatory pathways in the pathobiology of vascular remodeling and PH, and discuss potential therapeutic interventions that may halt disease progression or even reverse pulmonary vascular remodeling. Read More

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http://dx.doi.org/10.1007/s00059-019-4795-6DOI Listing
April 2019
1 Read

[Blood pressure targets in patients with diabetes mellitus : What are optimum values?]

Herz 2019 Mar 7. Epub 2019 Mar 7.

Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Universität des Saarlandes, Kirrberger Str., Geb. 41.1, 66421, Homburg/Saar, Deutschland.

Diabetes mellitus and arterial hypertension are the most prevalent diseases in the aging population. Both are important risk factors for the development of cardiovascular complications and are associated with a high mortality. Both diseases are often first recognized late. Read More

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http://dx.doi.org/10.1007/s00059-019-4796-5DOI Listing

Catheter ablation in atrial fibrillation: is there a mortality benefit in patients with diabetes and heart failure?

Herz 2019 Mar 7. Epub 2019 Mar 7.

Division of Cardiology, Department of Medical Sciences, "Città della Salute e della Scienza" Hospital, University of Turin, Corso Bramante 88, 10126, Turin, Italy.

Atrial fibrillation (AF) is the most commonly sustained arrhythmia, and patients with diabetes mellitus (DM) exhibit an increased incidence of AF. Besides DM, heart failure (HF) shares pathophysiological links with AF, mainly related to the pathological remodeling of hearts affected by structural disease. As in a vicious circle, AF may contribute to HF worsening and increased mortality in patients with structural heart diseases, and the outcome may be further impaired when concomitant DM is present. Read More

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http://dx.doi.org/10.1007/s00059-019-4794-7DOI Listing
March 2019
1 Read