8,771 results match your criteria Herz KardiovaskulA¤re Erkrankungen[Journal]


Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling.

Basic Res Cardiol 2019 02 20;114(2):13. Epub 2019 Feb 20.

Abt. Kardiologie und Pneumologie/Herzzentrum, Georg-August-Universität Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Increased late sodium current (late I) is an important arrhythmogenic trigger in cardiac disease. It prolongs cardiac action potential and leads to an increased SR Ca leak. This study investigates the contribution of Ca/Calmodulin-dependent kinase II (CaMKII), protein kinase A (PKA) and conversely acting protein phosphatases 1 and 2A (PP1, PP2A) to this subcellular crosstalk. Read More

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http://dx.doi.org/10.1007/s00395-019-0720-7DOI Listing
February 2019

Safety, procedural success and outcome of the AspirexS endovascular thrombectomy system in the treatment of iliofemoral deep vein thrombosis - data from the Arnsberg Aspirex registry.

Vasa 2019 Feb 20:1-6. Epub 2019 Feb 20.

3 Herz-Jesu-Krankenhaus Dernbach, Dernbach, Germany.

Background: Percutaneous mechanical thrombectomy (PMT) represents a treatment option in addition to conventional therapy for patients with iliofemoral deep vein thrombosis (DVT). We sought to determine the safety, patency and short-term outcome of the AspirexS catheter as a rotational mechanical thrombectomy device in the endovascular treatment of iliofemoral DVT.

Patients And Methods: 56 patients (66 % female, median age 51 years) undergoing mechanical thrombectomy with the AspirexS catheter for endovascular treatment of iliofemoral DVT were included in the analysis. Read More

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http://dx.doi.org/10.1024/0301-1526/a000779DOI Listing
February 2019

Clinical outcomes of the Lotus Valve in patients with bicuspid aortic valve stenosis: An analysis from the RESPOND study.

Catheter Cardiovasc Interv 2019 Feb 17. Epub 2019 Feb 17.

Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, CE, Rotterdam, The Netherlands.

Aims: Patients with bicuspid valves represent a challenging anatomical subgroup for transcatheter aortic valve implantation (TAVI). This analysis evaluated the clinical outcomes of the fully repositionable and retrievable Lotus Valve System in patients with bicuspid aortic valves enrolled in the RESPOND post-market registry.

Methods And Results: The prospective, open-label RESPOND study enrolled 1,014 patients at 41 centers in Europe, New Zealand, and Latin America, 31 (3. Read More

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http://dx.doi.org/10.1002/ccd.28120DOI Listing
February 2019

Anomalous aortic origin of coronary arteries: Early results on clinical management from an international multicenter study.

Int J Cardiol 2019 Feb 10. Epub 2019 Feb 10.

Section of Pediatric and Congenital Cardiac Surgery, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Medical School, Italy.

Background: Anomalous aortic origin of coronary arteries (AAOCA) is a rare abnormality, whose optimal management is still undefined. We describe early outcomes in patients treated with different management strategies.

Methods: This is a retrospective clinical multicenter study including patients with AAOCA, undergoing or not surgical treatment. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.02.007DOI Listing
February 2019
1 Read

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 02 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019
1 Read

Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention.

Cardiovasc Res 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Aim: A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Read More

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http://dx.doi.org/10.1093/cvr/cvz015DOI Listing
February 2019
1 Read

[Premature ventricular contractions and tachycardia in a structurally normal heart : Idiopathic PVC and VT].

Herzschrittmacherther Elektrophysiol 2019 Feb 14. Epub 2019 Feb 14.

Medizinische Klinik und Poliklinik I, Klinikum der Universität München, Ludwig-Maximilians-Universität München (LMU München), München, Deutschland.

Premature ventricular contractions (PVC) are a common, often incidental and mostly benign finding. Treatment is indicated in frequent and symptomatic PVC or in cases of worsening of left ventricular function. Idiopathic ventricular tachycardia (VT) is mostly found in patients with a structurally healthy heart. Read More

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http://link.springer.com/10.1007/s00399-019-0607-1
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http://dx.doi.org/10.1007/s00399-019-0607-1DOI Listing
February 2019
2 Reads

[Resected lung cancer in nonsmokers].

Authors:
K Hekmat C J Bruns

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik und Poliklinik Allgemein‑, Viszeral- und Tumorchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0893-5DOI Listing
February 2019

[Subsolid pulmonary nodules in low-dose computed tomography].

Authors:
K Hekmat C J Bruns

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik und Poliklinik Allgemein‑, Viszeral- und Tumorchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0913-5DOI Listing
February 2019

[Liquid biopsy : A blood sample for early recognition and therapy control in lung cancer patients].

Authors:
K Hekmat C Bruns

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik und Poliklinik Allgemein‑, Viszeral- und Tumorchirurgie, Universität zu Köln, Kerpener Str. 62, 50931, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0845-0DOI Listing
February 2019

[Lobectomy vs. radiotherapy for non-small-cell lung cancer patients].

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik und Poliklinik Allgemein‑, Viszeral- und Tumorchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0876-6DOI Listing
February 2019
1 Read

[Primary spontaneous pneumothorax : Is there an impact of weather conditions?]

Authors:
K Hekmat C J Bruns

Chirurg 2019 Feb 13. Epub 2019 Feb 13.

Klinik und Poliklinik Allgemein‑, Viszeral- und Tumorchirurgie, Universität zu Köln, Kerpener Straße 62, 50931, Köln, Deutschland.

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http://link.springer.com/10.1007/s00104-019-0863-y
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http://dx.doi.org/10.1007/s00104-019-0863-yDOI Listing
February 2019
4 Reads

Effect of iloprost inhalation on postoperative outcome in high-risk cardiac surgical patients: a prospective randomized-controlled multicentre trial (ILOCARD).

Can J Anaesth 2019 Feb 12. Epub 2019 Feb 12.

Klinik für Anästhesiologie, LMU Klinikum der Universität München, Munich, Germany.

Purpose: Perioperative right ventricular (RV) failure due to pressure overload from pulmonary hypertension (PH) worsens postoperative outcomes after cardiac surgery. Inhaled iloprost is a potent pulmonary vasodilator improving RV performance, ameliorating myocardial and pulmonary ischemia-reperfusion injury and attenuating inflammation. We hypothesized that the prophylactic inhalation of iloprost would reduce postoperative ventilation times after cardiac surgery. Read More

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http://dx.doi.org/10.1007/s12630-019-01309-8DOI Listing
February 2019

Inflammation in thoracic aortic aneurysms.

Herz 2019 Feb 12. Epub 2019 Feb 12.

Faculty of Medicine, Department of Anatomy and Cell Biology and Faculty of Dentistry, McGill University, Montreal, Canada.

Mutations in extracellular matrix and smooth muscle cell contractile proteins predispose to thoracic aortic aneurysms in Marfan syndrome (MFS) and related disorders. These genetic alterations lead to a compromised extracellular matrix-smooth muscle cell contractile unit. The abnormal aortic tissue responds with defective mechanosensing under hemodynamic stress. Read More

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http://dx.doi.org/10.1007/s00059-019-4786-7DOI Listing
February 2019

Shedding Light Into Late Saphenous Vein Graft Failure.

Cardiovasc Revasc Med 2019 Jan;20(1):6-8

Deutsches Herzzentrum München, Munich, Germany; Deutsches Zentrum für Herz- und Kreislaufforschung e.V., Berlin, Germany.

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http://dx.doi.org/10.1016/j.carrev.2018.12.008DOI Listing
January 2019

Off-pump Revascularization with Bilateral versus Single Mammary Arteries-A Propensity Score-Matched Analysis.

Thorac Cardiovasc Surg 2019 Feb 9. Epub 2019 Feb 9.

Department of Cardio-Thoracic Surgery, Heart Center NRW, Bad Oeynhausen, Germany.

Background:  Coronary artery bypass grafting is the first-line therapy for severe multivessel coronary artery disease. We aimed to investigate the clinical outcome in patients undergoing isolated off-pump surgery with the single or bilateral internal mammary artery (SIMA or BIMA) approach.

Methods:  We performed a propensity score-matched analysis in 1,852 consecutive patients, aged 50 to 70 years, who underwent myocardial revascularization at our institution between July 2009 and August 2016. Read More

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http://dx.doi.org/10.1055/s-0039-1677835DOI Listing
February 2019

Five-Year Outcome after Off-Pump or On-Pump Coronary Artery Bypass Grafting in Elderly Patients.

Circulation 2019 Feb 8. Epub 2019 Feb 8.

Cardiac Surgery, Cardiovascular Clinic Bad Neustadt, Germany.

Background: The 30 days and one-year follow-up analysis of the German Off-Pump Coronary Artery Bypass Grafting in Elderly Patients (GOPCABE) trial revealed no significant difference in the composite endpoint consisting of death, stroke, myocardial infarction, new renal replacement therapy or repeat revascularization. The five-year follow-up data of this trial are reported here.

Methods: From June 2008 to September 2011 a total of 2539 patients aged 75 years or older were randomly assigned to undergo off-pump or on-pump coronary artery bypass grafting (CABG) at 12 centers in Germany. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035857DOI Listing
February 2019

Protein Microarray Copying - Easy on-demand protein microarray generation compatible with fluorescence as well as label-free real-time analysis.

Chembiochem 2019 Feb 7. Epub 2019 Feb 7.

Albert-Ludwigs-Universitat Freiburg, GERMANY.

Protein microarrays are essential to understand complex protein interaction networks. Their production, however, is a challenge rendering this technology unattractive for many laboratories. Recent developments in cell-free protein microarray generation offer new opportunities, but are still expensive and cumbersome in practice. Read More

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http://dx.doi.org/10.1002/cbic.201800699DOI Listing
February 2019

[How it all started].

Herz 2019 Feb;44(1):1-3

Praxisklinik Herz und Gefäße, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s00059-018-4771-6DOI Listing
February 2019

Critical inflammatory mechanisms underlying arrhythmias.

Herz 2019 Feb 7. Epub 2019 Feb 7.

Klinik für Angiologie und Kardiologie, Westdeutsches Herz- und Gefäßzentrum Essen, Universitätsklinikum der Universität Essen, Hufelandstr. 55, 45147, Essen, Germany.

During the past few decades, cardiovascular research has increasingly focused on systemic inflammatory mechanisms, particularly in the field of atherosclerosis but also in association with cardiac arrhythmogenesis. Objective inflammatory markers including C‑reactive protein and cytokines, also called "biomarkers," seem to serve as predictors of onset and prognosis of cardiac arrhythmias. This review gives an overview of potential mechanisms underlying inflammatory processes and arrhythmias, especially atrial fibrillation, which is the most common sustained arrhythmia in daily clinical routine. Read More

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http://dx.doi.org/10.1007/s00059-019-4788-5DOI Listing
February 2019

Pericardial fluids or Cardiopulmonary Bypass-Is There a Major Culprit for Changes in Coagulation and Inflammation?

Thorac Cardiovasc Surg 2019 Feb 6. Epub 2019 Feb 6.

Herz-, Thorax- und Gefäßchirurgie, Universitätsklinik Ulm, Ulm, Germany.

Background:  From the results of a previous study, it remained to be investigated if a perioperative rise of few tested coagulation and inflammation markers is caused by conventional cardiopulmonary bypass (CPB) itself or rather by direct recirculation of pericardial fluids.

Methods:  Forty-eight patients operated on with conventional CPB for myocardial revascularization were randomized either for direct recirculation of pericardial suction fluids or for cell saving (CS).

Results:  Thrombin-antithrombin complexes showed lower values intraoperatively in the CS group ( < 0. Read More

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http://dx.doi.org/10.1055/s-0039-1677836DOI Listing
February 2019

Risk of atrial fibrillation in big people under the magnifying glass of G. J. Mendel.

Eur Heart J 2019 Feb 5. Epub 2019 Feb 5.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technical University Munich, Lazarettstr. 36, Munich, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehz037DOI Listing
February 2019

Serum 25-hydroxyvitamin D response to vitamin D supplementation in infants: a systematic review and meta-analysis of clinical intervention trials.

Eur J Nutr 2019 Feb 5. Epub 2019 Feb 5.

Department of Internal Medicine and Geriatrics, Bethel Clinic (EvKB), 33611, Bielefeld, Germany.

Purpose: For the prevention of nutritional rickets, 400 IU vitamin D daily and circulating 25-hydroxyvitamin D (25OHD) concentrations > 50 nmol/L are recommended, whereas the toxicity threshold is set at 250 nmol/L. We synthesized the evidence for the effect of vitamin D supplementation on incremental 25OHD in infants up to 1 year of age.

Methods: We performed a systematic review and meta-analysis of intervention trials in several databases. Read More

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http://dx.doi.org/10.1007/s00394-019-01912-xDOI Listing
February 2019
1 Read
3.467 Impact Factor

Age-Dependent Protein Expression of Serine/Threonine Phosphatases and Their Inhibitors in the Human Cardiac Atrium.

Adv Med 2019 2;2019:2675972. Epub 2019 Jan 2.

Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, 06112 Halle (Saale), Germany.

Heart failure and aging of the heart show many similarities regarding hemodynamic and biochemical parameters. There is evidence that heart failure in experimental animals and humans is accompanied and possibly exacerbated by increased activity of protein phosphatase (PP) 1 and/or 2A. Here, we wanted to study the age-dependent protein expression of major members of the protein phosphatase family in human hearts. Read More

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http://dx.doi.org/10.1155/2019/2675972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334353PMC
January 2019

Key inflammatory mechanisms underlying heart failure.

Herz 2019 Feb 4. Epub 2019 Feb 4.

Department of Cardiology and Angiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Inflammation plays a central role in the development of heart failure, especially in heart failure with preserved ejection fraction (HFpEF). Furthermore, the inflammatory response enables the induction of regenerative processes following acute myocardial injury. Recent studies in humans and animals have greatly advanced our understanding of the underlying mechanisms behind these adaptations. Read More

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http://link.springer.com/10.1007/s00059-019-4785-8
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http://dx.doi.org/10.1007/s00059-019-4785-8DOI Listing
February 2019
2 Reads

Conservation and divergence of the p53 gene regulatory network between mice and humans.

Authors:
Martin Fischer

Oncogene 2019 Feb 1. Epub 2019 Feb 1.

Computational Biology Group, Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), 07745, Jena, Germany.

Understanding the p53 tumor suppressor pathway remains crucial for the design of anticancer strategies. Studies in human tumors and mouse models help to unravel the molecular mechanisms that underlie the p53 signaling pathway. Yet, the p53 gene regulatory network (GRN) is not the same in mice and humans. Read More

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http://www.nature.com/articles/s41388-019-0706-9
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http://dx.doi.org/10.1038/s41388-019-0706-9DOI Listing
February 2019
4 Reads

Heart failure among people with Type 2 diabetes mellitus: real-world data of 289 954 people from a diabetes database.

Diabet Med 2019 Jan 30. Epub 2019 Jan 30.

Institut für Epidemiologie und medizinische Biometrie, ZIBMT, Universität Ulm, Ulm.

Aim: Comparing people with Type 2 diabetes mellitus with and without heart failure in terms of metabolic control, therapeutic regimen and comorbidities.

Methods: The Prospective Diabetes Registry (DPV) is a longitudinal documentation system for demographics, medical care and outcome in people with diabetes mellitus. It consists of follow-up data from people with diabetes mellitus who have agreed to be recorded in the registry. Read More

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http://doi.wiley.com/10.1111/dme.13915
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http://dx.doi.org/10.1111/dme.13915DOI Listing
January 2019
7 Reads

Assessing the level of radiation experienced by anesthesiologists during transfemoral Transcatheter Aortic Valve Implantation and protection by a lead cap.

PLoS One 2019 30;14(1):e0210872. Epub 2019 Jan 30.

Institut für Anästhesiologie, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Objective: Transfemoral Transcatheter Aortic Valve Implantation (TAVI) has become a standard therapy for patients with aortic valve stenosis. Fluoroscopic imaging is essential for TAVI with the anesthesiologist's workplace close to patient's head side. While the use of lead-caps has been shown to be useful for interventional cardiologists, data are lacking for anesthesiologists. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353158PMC
January 2019
2 Reads

Functional Metagenomics Reveals an Overlooked Diversity and Novel Features of Soil-Derived Bacterial Phosphatases and Phytases.

MBio 2019 Jan 29;10(1). Epub 2019 Jan 29.

Department of Genomic and Applied Microbiology and Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August University, Göttingen, Germany

Phosphatases, including phytases, play a major role in cell metabolism, phosphorus cycle, biotechnology, and pathogenic processes. Nevertheless, their discovery by functional metagenomics is challenging. Here, soil metagenomic libraries were successfully screened for genes encoding phosphatase activity. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01966-18
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http://dx.doi.org/10.1128/mBio.01966-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355987PMC
January 2019
1 Read

Transcatheter aortic valve replacement in atypical valve anatomy using the Lotus valve : A Chinese single-center experience.

Herz 2019 Jan 29. Epub 2019 Jan 29.

Department of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.

Background: In the West, the safety and efficacy of the Lotus valve have been demonstrated; however, data in the Chinese population are still lacking. Few studies have compared the clinical outcomes of transcatheter aortic valve replacement (TAVR) with the Lotus valve in patients with bicuspid or tricuspid aortic valve stenosis. Our aim was to assess TAVR outcomes with the Lotus aortic valve in a Chinese patient cohort. Read More

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http://dx.doi.org/10.1007/s00059-018-4778-zDOI Listing
January 2019
2 Reads

Erratum to: Efficacy of liraglutide intervention in myocardial infarction : A meta-analysis of randomized controlled trials.

Authors:
X Yang Z Liang

Herz 2019 Jan 29. Epub 2019 Jan 29.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Sichuan, China.

Erratum to: Herz 2018 https://doi.org/10.1007/s00059-018-4748-5 In the above mentioned article, the affiliations of the authors and the corresponding address were not given correctly. Read More

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http://dx.doi.org/10.1007/s00059-019-4784-9DOI Listing
January 2019

Anticipatory neural activity improves the decoding accuracy for dynamic head-direction signals.

J Neurosci 2019 Jan 28. Epub 2019 Jan 28.

Bernstein Center for Computational Neuroscience Munich and Faculty of Biology, Ludwig-Maximilians-Universität München, Grosshadernerstrasse 2, 82152 Planegg-Martinsried, Germany

Insects and vertebrates harbor specific neurons that encode the animal's head direction (HD) and provide an internal compass for spatial navigation. Each HD cell fires most strongly in one preferred direction. As the animal turns its head, however, HD cells in rat anterodorsal thalamic nucleus (ADN) and other brain areas fire already before their preferred direction is reached, as if the neurons anticipated the future head direction. Read More

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http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.2605-1
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http://dx.doi.org/10.1523/JNEUROSCI.2605-18.2019DOI Listing
January 2019
3 Reads

Exenatide Delays Gastric Emptying in Patients with Type 2 Diabetes Mellitus but not in Those with Gastroparetic Conditions.

Horm Metab Res 2019 Jan 28. Epub 2019 Jan 28.

Herz- und Diabeteszentrum NRW, Diabeteszentrum, Ruhr-Universität Bochum, Bad Oeynhausen, Germany.

The effect of the treatment with glucagon-like peptide (GLP)-1 receptor agonists on gastric emptying in patients with diabetes with and without gastroparesis is analysed. Patients with type 2 diabetes mellitus subjected to GLP-1 receptor agonist therapy with exenatide were examined before and shortly after initiation of treatment. Gastric half-emptying time was determined by C-octanoic breath test; routine laboratory parameter as well as active GLP-1, ghrelin, leptin, insulin, proinsulin and C-peptide levels were determined in fasting state as well as postprandial secretion within 1 h after a standardised meal. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0818-6374
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http://dx.doi.org/10.1055/a-0818-6374DOI Listing
January 2019
4 Reads

Outcome after transvascular transcatheter aortic valve implantation in 2016: a closer look.

Eur Heart J 2019 Feb;40(5):492

Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie, Berlin, Germany.

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http://dx.doi.org/10.1093/eurheartj/ehy740DOI Listing
February 2019
1 Read

[Antithrombotic treatment in acute coronary syndrome and atrial fibrillation].

Herz 2019 Feb;44(1):29-34

Gerinnungspraxis im Cardio Centrum Mainz, Mainz, Deutschland.

The number of patients with atrial fibrillation (AF) is increasing due to the aging of the population. In addition, the number of patients with AF and indications for oral anticoagulation (OAC) for the prevention of stroke, who need dual antiplatelet treatment (DAPT) with acetylsalicylic acid (ASA) plus a PY inhibitor because of an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) is also increasing. In the past these patients received a triple therapy (TT) for 3-12 months. Read More

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http://dx.doi.org/10.1007/s00059-019-4781-zDOI Listing
February 2019

[Troponins as biomarkers for myocardial injury and myocardial infarction].

Herz 2019 Feb;44(1):4-9

Medizinische Klinik II, Klinikum Rüsselsheim, August-Bebel-Str. 59, 65428, Rüsselsheim, Deutschland.

Elevation of cardiac troponins above the 99th percentile of a healthy reference population is established as a marker for myocardial cell damage and is crucial for the diagnosis of myocardial infarction. In addition, corresponding clinical evidence of acute myocardial ischemia i.e. Read More

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http://dx.doi.org/10.1007/s00059-019-4783-xDOI Listing
February 2019
2 Reads

High-throughput single-cell rheology in complex samples by dynamic real-time deformability cytometry.

Nat Commun 2019 01 24;10(1):415. Epub 2019 Jan 24.

Zentrum für Innovationskompetenz: Humorale Immunreaktionen bei kardiovaskulären Erkrankungen, Universität Greifswald, Fleischmannstr. 42, 17489, Greifswald, Germany.

In life sciences, the material properties of suspended cells have attained significance close to that of fluorescent markers but with the advantage of label-free and unbiased sample characterization. Until recently, cell rheological measurements were either limited by acquisition throughput, excessive post processing, or low-throughput real-time analysis. Real-time deformability cytometry expanded the application of mechanical cell assays to fast on-the-fly phenotyping of large sample sizes, but has been restricted to single material parameters as the Young's modulus. Read More

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http://dx.doi.org/10.1038/s41467-019-08370-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346011PMC
January 2019

Next-generation sequencing of 32 genes associated with hereditary aortopathies and related disorders of connective tissue in a cohort of 199 patients.

Genet Med 2019 Jan 24. Epub 2019 Jan 24.

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Purpose: Heritable factors play an important etiologic role in connective tissue disorders (CTD) with vascular involvement, and a genetic diagnosis is getting increasingly important for gene-tailored, personalized patient management.

Methods: We analyzed 32 disease-associated genes by using targeted next-generation sequencing and exome sequencing in a clinically relevant cohort of 199 individuals. We classified and refined sequence variants according to their likelihood for pathogenicity. Read More

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http://www.nature.com/articles/s41436-019-0435-z
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http://dx.doi.org/10.1038/s41436-019-0435-zDOI Listing
January 2019
3 Reads

[Acute coronary syndrome : Prevention].

Herz 2019 Feb;44(1):45-52

Abteilung 1 (Kardiologie, Diabetologie), Paracelsus-Harz-Klinik Bad Suderode, Quedlinburg, Deutschland.

For life style modifications primary and secondary prevention of acute coronary syndrome (ACS) are approximately similar, even though in the postinfarction situation functional diagnostic programs have to be performed in a rehabilitative manner. All three life style pillars of fitness, nutrition and relaxation implicate prognostic significance and the efficacy is higher for secondary prevention than for primary. The pharmacotherapeutic indications for thrombocyte aggregation inhibition are connected to the presence of atherosclerosis and statin medication is already connected to cardiovascular risk factor stratification, for which scores are used. Read More

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http://dx.doi.org/10.1007/s00059-019-4782-yDOI Listing
February 2019
2 Reads

Targeting mannose receptor expression on macrophages in atherosclerotic plaques of apolipoprotein E-knockout mice using Ga-NOTA-anti-MMR nanobody: non-invasive imaging of atherosclerotic plaques.

EJNMMI Res 2019 Jan 21;9(1). Epub 2019 Jan 21.

Department of Nuclear Medicine, Klinikum rechts der Isar der TUM, Ismaninger-Strasse 22, 81675, Munich, Germany.

Background: Rupture-prone atherosclerotic plaques are characterized by heavy macrophage infiltration, and the presence of certain macrophage subsets might be a sign for plaque vulnerability. The mannose receptor (MR, CD206) is over-expressed in several types of alternatively activated macrophages. In this study, our objective was to evaluate the feasibility of a Gallium-68 (Ga)-labelled anti-MR nanobody (Ga-anti-MMR Nb) for the visualization of MR-positive (MR) macrophages in atherosclerotic plaques of apolipoprotein E-knockout (ApoE-KO) mice. Read More

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https://ejnmmires.springeropen.com/articles/10.1186/s13550-0
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http://dx.doi.org/10.1186/s13550-019-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340911PMC
January 2019
3 Reads

[Extracorporeal Membrane Oxygenation in Thoracic Surgery: Establishing Functional and Technical Operability].

Zentralbl Chir 2019 Feb 21;144(1):78-85. Epub 2019 Jan 21.

Klinik für Herz- und Thoraxchirurgie, Sektion Thoraxchirurgie, Universitätsklinikum Münster, Deutschland.

Functional and technical operability has to be evaluated and defined prior to thoracic surgical procedures. Sometimes patients assigned to thoracic surgery procedures have to be declared inoperable due to functional und technical limitations. Extracorporeal lung support is an important tool to establish functional and technical operability in patients undergoing thoracic surgical procedures. Read More

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http://dx.doi.org/10.1055/a-0800-0178DOI Listing
February 2019
1 Read

Flawed methods and inappropriate conclusions for health policy on overweight and obesity: the Global BMI Mortality Collaboration meta-analysis.

J Cachexia Sarcopenia Muscle 2019 Jan 17. Epub 2019 Jan 17.

Division of Cardiology and Metabolism; Department of Cardiology (CVK), Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Charité-Universitätsmedizin Berlin, Berlin, Germany.

Guideline recommendations and health policy decisions rely on evidence from clinical and epidemiological studies. Adequate methodology and appropriate conclusions are essential to support healthcare and health policy decisions. An analysis of body mass index and mortality by the Global BMI Mortality Collaboration (GBMC) concluded that the association of excess body weight with higher mortality was similar worldwide and that overweight and obesity should be combated everywhere. Read More

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http://dx.doi.org/10.1002/jcsm.12378DOI Listing
January 2019
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Preventive use of carvedilol for anthracycline-induced cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials.

Herz 2019 Jan 17. Epub 2019 Jan 17.

Department of Geriatric Medicine, The Second Affiliated Hospital, Hunan University of Chinese Medicine, 233 North Cai'e Rd., Kaifu District, 410005, Changsha, Hunan, China.

Background: Clinical or subclinical cardiotoxicity is a concern for cancer patients receiving anthracycline-based chemotherapy. Carvedilol is promising for preventing anthracycline-induced cardiotoxicity (AIC). This review appraised the preventive effects of carvedilol against AIC based on randomized controlled trials (RCTs). Read More

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http://dx.doi.org/10.1007/s00059-018-4779-yDOI Listing
January 2019

[Cardiac manifestations of tropical diseases].

Authors:
C Kraef M Ramharter

Herz 2019 Feb;44(1):83-91

Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Bernhard-Nocht-Straße 74, 20359, Hamburg, Deutschland.

Due to an increase in global mobility, international travel and migration, tropical diseases are more frequently observed in Germany. Some tropical diseases can also affect the heart, cause cardiac symptoms and may require inclusion in differential diagnostic work-ups. The most important tropical diseases with cardiac involvement are Chagas' disease and echinococcosis. Read More

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http://dx.doi.org/10.1007/s00059-018-4780-5DOI Listing
February 2019
1 Read

Vitamin D supplementation of 4000 IU daily and cardiac function in patients with advanced heart failure: The EVITA trial.

Int J Cardiol 2019 Apr 9;280:117-123. Epub 2019 Jan 9.

Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr University Bochum, Bad Oeynhausen, Germany.

Background: Data regarding the effects of vitamin D on cardiac function are inconclusive.

Methods: In a post-hoc analysis of the EVITA (Effect of vitamin D on mortality in heart failure) trial, we investigated whether a daily vitamin D supplement of 4000 IU for three years affects echocardiography parameters like left ventricular end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), and LV ejection fraction (LVEF) in patients with advanced heart failure (HF) and 25‑hydroxyvitamin D levels <75 nmol/L. Of 400 patients enrolled, 199 were assigned to vitamin D and 201 to placebo. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.027DOI Listing
April 2019
3 Reads

Brain responses to other people's pain in fibromyalgia: a magnetoencephalography study.

Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):70-74. Epub 2019 Jan 9.

Department of Internal Medicine H, Tel Aviv Sourasky Medical Centre & Sakler School of Medicine, Tel Aviv University, Israel.

Objectives: We investigated whether the central pain symptoms in fibromyalgia syndrome (FM) are related to defective top-down sensorimotor regulation. The pain matrix was activated in a top-down manner by presenting pictures of painful situations while recording brain activity using magnetoencephalography (MEG). We investigated alpha desynchronisation in FM patients and healthy controls in response to pictures depicting pain. Read More

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January 2019
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Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction.

Eur J Heart Fail 2019 Jan 16. Epub 2019 Jan 16.

Department of Cardiology and Pneumology and The German Center for Cardiovascular Research (DZHK), University Medicine Göttingen (UMG), Göttingen, Germany.

Aims: Cardiac contractility modulation (CCM) improves symptoms and exercise tolerance and reduces heart failure (HF) hospitalizations over 6-month follow-up in patients with New York Heart Association (NYHA) class III or IV symptoms, QRS < 130 ms and 25% ≤ left ventricular ejection fraction (LVEF) ≤ 45% (FIX-HF-5C study). The current prospective registry study (CCM-REG) aimed to assess the longer-term impact of CCM on hospitalizations and mortality in real-world experience in this same population.

Methods And Results: A total of 140 patients with 25% ≤ LVEF ≤ 45% receiving CCM therapy (CCM-REG ) for clinical indications were included. Read More

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http://doi.wiley.com/10.1002/ejhf.1374
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http://dx.doi.org/10.1002/ejhf.1374DOI Listing
January 2019
4 Reads

Vitamin D testing and treatment: a narrative review of current evidence.

Endocr Connect 2019 Feb;8(2):R27-R43

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Vitamin D testing and treatment is a subject of controversial scientific discussions, and it is challenging to navigate through the expanding vitamin D literature with heterogeneous and partially opposed opinions and recommendations. In this narrative review, we aim to provide an update on vitamin D guidelines and the current evidence on the role of vitamin D for human health with its subsequent implications for patient care and public health issues. Vitamin D is critical for bone and mineral metabolism, and it is established that vitamin D deficiency can cause rickets and osteomalacia. Read More

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http://dx.doi.org/10.1530/EC-18-0432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365669PMC
February 2019
2 Reads

Genetic Assessment of Potential Long-Term On-Target Side Effects of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors.

Circ Genom Precis Med 2019 Jan;12(1):e002196

Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom (C.P.N., F.Y.L., M.N., S.Y., T.R.W., N.J.S.).

Background: Although short-term trials have suggested that PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are safe and reduce risk of cardiovascular diseases, their long-term safety is unclear. Genetic variants associated with lower activity of a gene can act as proxies to identify potential long-term side effects of drugs as recently exemplified by association of LDL (low-density lipoprotein)-lowering variants in the HMGCR (target for statins) and PCSK9 genes with increased risk of type 2 diabetes mellitus (T2DM). However, analyses of the full spectrum of potential side effects of PCSK9 inhibition using a genetic approach have not been undertaken. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002196
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http://dx.doi.org/10.1161/CIRCGEN.118.002196DOI Listing
January 2019
18 Reads