7,520 results match your criteria Herpetic Whitlow
BMC Med 2018 Dec 6;16(1):228. Epub 2018 Dec 6.
Unit of PharmacoTherapy, -Epidemiology & -Economics (PTE2), University of Groningen, Groningen Research Institute of Pharmacy, Groningen, The Netherlands.
Background: The newly registered adjuvanted herpes zoster subunit vaccine (HZ/su) has a higher efficacy than the available live-attenuated vaccine (ZVL). National decision-makers soon need to decide whether to introduce HZ/su or to prefer HZ/su above ZVL.
Methods: Using a Markov model with a decision tree, we conducted a cost-effectiveness analysis of vaccination with HZ/su (two doses within 2 months) or zoster vaccine live (ZVL) (single dose, or single dose with a booster after 10 years) for cohorts of 50-, 60-, 70- or 80-year-olds in the Netherlands. Read More
Blood Purif 2018 Dec 5:1-6. Epub 2018 Dec 5.
Renal failure patients have an increased risk of infection, including skin and soft tissue infections. This increased susceptibility is multifactorial, due to the conditions causing the renal failure as well as complications of treatment and renal failure's innate effects on patient health. These infections have a significant impact on patient morbidity, increased hospital and procedural demands, and the cost of health care. Read More
J Virol 2018 Nov 28. Epub 2018 Nov 28.
Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, California, USA
A large proportion of the world population harbors herpes simplex virus type 1 (HSV-1) a major cause of infectious corneal blindness. HSV-specific CD8 T cells protect from herpes infection and disease. However, the genomic, phenotypic and functional characteristics of CD8 T cells associated with the protection seen in asymptomatic (ASYMP) individuals, who despite being infected, never experienced any recurrent herpetic disease, remains to be fully elucidated. Read More
Complement Ther Med 2018 Dec 21;41:277-282. Epub 2018 Oct 21.
Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan. Electronic address:
Background: Postherpetic neuralgia (PHN) is the most distressful complication of herpes zoster. PHN results in an impaired quality of life and higher healthcare utilization. Vitamin B12 has been proven to be effective in pain relief for various conditions. Read More
Photodiagnosis Photodyn Ther 2018 Nov 14. Epub 2018 Nov 14.
Hamadan University of Medical Sciences, Iran. Electronic address:
Introduction: Herpes simplex virus (HSV) is among the most common viruses in humans. HSV1 is often responsible for oral and perioral herpetic lesions. Photodynamic therapy (PDT) is a novel antimicrobial modality that involves the use of laser and a photosensitizer with a specific wavelength. Read More
Ocul Immunol Inflamm 2018 Nov 16:1-3. Epub 2018 Nov 16.
b Ophthalmology , University of Rochester David and Ilene Flaum Eye Institute , Rochester , New York , USA.
Purpose: To describe an uncommon presentation of ocular infection caused by human herpes simplex virus 2 (HSV-2).
Methods: Case report.
Results: A 32-year-old female with no prior history of mucocutaneous herpesvirus infection presented with a minimally painful hypertensive granulomatous panophthalmitis and optic neuropathy that was initially suspected to be orbital cellulitis. Read More
JAMA Dermatol 2018 Dec;154(12):1487-1488
Department of Dermatology, University of Rochester, Rochester, New York.
Acad Emerg Med 2018 Nov 12. Epub 2018 Nov 12.
University of Pittsburgh Medical Center, Department of Emergency Medicine, Pittsburgh, PA.
Post herpetic neuralgia (PHN) is a condition of persistent, refractory pain in an area previously affected by an acute herpes zoster infection. Age remains an important risk factor for the development of PHN, with 40% of patients older than 50 years and 75% of patients 75 years and older developing PHN after an initial episode of shingles. Persistent pain can lead to significant long-term problems such as depression, altered activities of daily living, and anorexia. Read More
Acad Emerg Med 2018 Nov 12. Epub 2018 Nov 12.
University of Pittsburgh Medical Center, Department of Emergency Medicine, Pittsburgh, PA.
Post-herpetic neuralgia is a painful condition of persistent chronic pain following acute reactivation of varicella zoster virus. The review defines PHN as persisting or recurring pain at the site of shingles at least one month after the onset of the acute rash. The incidence of shingles increases with age, almost doubling in each decade after 50 years of age. Read More
Sci Rep 2018 Nov 9;8(1):16662. Epub 2018 Nov 9.
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Acyclovir (ACV) is an effective antiviral agent for treating lytic Herpes Simplex virus, type 1 (HSV-1) infections, and it has dramatically reduced the mortality rate of herpes simplex encephalitis. However, HSV-1 resistance to ACV and its derivatives is being increasingly documented, particularly among immunocompromised individuals. The burgeoning drug resistance compels the search for a new generation of more efficacious anti-herpetic drugs. Read More
Front Neurosci 2018 23;12:750. Epub 2018 Oct 23.
Neuroscience Research Institute, Peking University, Beijing, China.
In acute and ongoing pain, the spontaneous oscillatory activity of electroencephalogram (EEG) has been characterized by suppression of alpha band oscillations and enhancement of gamma band oscillations. In pathological chronic pain which is more severe and common in clinic practice, it is of great interest to investigate the oscillatory activity especially at the broad gamma frequency bands. Our present study explored the resting state oscillatory activities of EEG in patients with post-herpetic neuralgia (PHN) over 3 months which is a typical neuropathic pain model in clinical researches. Read More
J Clin Neurosci 2018 Oct 28. Epub 2018 Oct 28.
Department of Neurology, Wayne State University/Detroit Medical Center, United States.
Gabapentin (GBP) and pregabalin (PGB) are FDA approved for adjunctive treatment of partial seizures and for treatment of post-herpetic neuralgia. Both drugs are primarily eliminated by renal excretion. However, PGB or GBP induced myoclonus has only been reported infrequently in case reports/series. Read More
Ann Dermatol Venereol 2018 Oct 23. Epub 2018 Oct 23.
Marie-Victoire Senat, service de gynécologie-obstétrique, Paris-Sud-université Paris-Saclay, hôpital Bicêtre, AP-HP, Le Kremlin Bicêtre, France.
TREATMENT OF THE INITIAL INFECTION OR FIRST CLINICAL EPISODE OF GENITAL HERPES: An initial infection or first clinical episode of genital herpes is treated with oral aciclovir 200mg×5/d for 5 to 10 days depending on clinical status. The recommended dosage for valaciclovir is 1g×2/d and treatment duration is identical to that for aciclovir. TREATMENT OF HERPES RECURRING DURING PREGNANCY: There are no studies of the efficacy of antiviral therapy on the symptoms of genital recurring during pregnancy. Read More
BMJ 2018 Oct 25;363:k4029. Epub 2018 Oct 25.
Department of Medicine, University of Toronto, Toronto, ON, Canada.
Objective: To compare the efficacy, effectiveness, and safety of the herpes zoster live attenuated vaccine with the herpes zoster adjuvant recombinant subunit vaccine or placebo for adults aged 50 and older.
Design: Systematic review with bayesian meta-analysis and network meta-analysis.
Data Sources: Medline, Embase, and Cochrane Library (inception to January 2017), grey literature, and reference lists of included studies. Read More
Indian J Ophthalmol 2018 Nov;66(11):1647-1649
Department of Internal Medicine, Singapore General Hospital; Department of Ophthalmology, Duke-NUS Medical School, Singapore.
A 67-year-old male patient with poorly controlled type-2 diabetes mellitus developed an orbital apex syndrome and anterior cavernous syndrome secondary to herpetic zoster ophthalmicus (HZO), despite being on oral acyclovir. Urgent treatment with intravenous acyclovir led to improvement of the orbital and ocular inflammation but had no effect on the complete ophthalmoplegia and profound visual loss. At the 9-month follow-up visit, the patient had complete unilateral ophthalmoplegia and monocular blindness due to optic atrophy. Read More
J Pain Res 2018 4;11:2179-2188. Epub 2018 Oct 4.
Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Objective: This study was to evaluate the effectiveness of ultrasound-guided percutaneous ozone injections around the cervical dorsal root ganglions of zoster-associated pain (ZAP) patients.
Study Design: Retrospective comparative study.
Settings: The study was conducted at a pain center of a university hospital. Read More
Ocul Immunol Inflamm 2018 Oct 12:1-8. Epub 2018 Oct 12.
b Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
Purpose: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy.
Methods: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR).
Results: The study included 112 eyes in 109 patients: 54 (48. Read More
Korean J Ophthalmol 2018 Oct;32(5):353-360
Department of Ophthalmology, Gyeongsang National University School of Medicine, Jinju, Korea.
Purpose: To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis.
Methods: This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 to January 2015. Clinical features, ocular complications, and recurrences were recorded. Read More
Contemp Clin Dent 2018 Sep;9(Suppl 2):S373-S376
Department of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, India.
Childhood pemphigus vulgaris (CPV) is a rare entity with clinical features and management primarily similar to those of adults; diagnosis may be difficult due to clinical similarity to other disorders such as herpetic gingivostomatitis which is more prevalent in this age group. We report two cases of CPV with emphasis on diagnostic approach. While treating such patients, it is imperative to diagnose CPV in the early stages to prevent serious morbidity and to adjust drug dosage to minimize side effects. Read More
Mult Scler 2018 Oct 5:1352458518796675. Epub 2018 Oct 5.
University of Cambridge School of Clinical Medicine, Cambridge, UK.
Background: Reduced MS disease activity with alemtuzumab versus subcutaneous interferon beta-1a (SC IFNB-1a) in core phase 2/3 studies was accompanied by increased incidence of infections that were mainly nonserious and responsive to treatment. Alemtuzumab efficacy was durable over 6 years.
Objective: To evaluate infections over 6 years in alemtuzumab-treated patients. Read More
Acta Ophthalmol 2018 Oct 3. Epub 2018 Oct 3.
Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Purpose: To compare topical cyclosporine-A 2% eye drop (Cs-A) with prednisolone acetate 1% eye drop for treatment of herpetic stromal keratitis (HSK).
Methods: In this randomized clinical trial, 38 eyes of 33 patients with HSK were randomly assigned to receive either 2% Cs-A or 1% prednisolone acetate eye drops. All subjects received oral acyclovir 400 mg twice a day. Read More
Infect Disord Drug Targets 2018 Oct 1. Epub 2018 Oct 1.
Kids Research Institute, The Children's Hospital at Westmead, Westmead, NSW 2145. United Kingdom.
HSV is an important cause of brain infection. Virus entry is often through breeches in the skin. γδT cells play an immunoprotective role in mice after corneal, genital or footpad (subcutaneous) HSV infection. Read More
J Ultrasound Med 2018 Sep 23. Epub 2018 Sep 23.
Department of Rehabilitation Medicine, Bundang Jesaeng Hospital, Seongnam-si, Korea.
Objectives: To compare the efficacy of a conventional fluoroscopy-guided epidural nerve block and an ultrasound (US)-guided intercostal nerve block in patients with thoracic herpes zoster (HZ).
Methods: This work was a comparative study of 38 patients with thoracic HZ pain and a chest wall herpetic eruption, aged 18 years or older, with pain intensity of 5 or greater on a numeric rating scale (NRS) for less than a 1-month duration. Patients were consecutively enrolled and assigned to 2 groups in which the intervention was either the US-guided intercostal nerve block or the fluoroscopy-guided epidural nerve block approach with the addition of a 5-mL mix of 2. Read More
J Matern Fetal Neonatal Med 2018 Oct 29:1-6. Epub 2018 Oct 29.
a Department of Obstetrics and Gynecology , Mie University Faculty Medicine , Tsu , Japan.
Purpose: Hepatitis due to herpes simplex virus (HSV) during pregnancy is rare, it is often not included in the differential disease. However, hepatitis leads to maternal death; hence, early diagnosis is necessary. Hepatic enzyme elevation in late pregnancy is often associated with obstetric-related diseases, such as acute gestational fatty liver and HELLP syndrome (hemolytic anemia, elevated liver enzymes, low platelet count). Read More
Am J Otolaryngol 2018 Nov - Dec;39(6):759-763. Epub 2018 Sep 12.
Otolaryngology, Head and Neck Department, Minia University Hospital, Minia, Egypt.
Purpose: Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
Material And Methods: This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. Read More
J Immunol 2018 Oct 10;201(8):2315-2330. Epub 2018 Sep 10.
Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA 92697;
HSV type 1 (HSV-1)-specific CD8 T cells protect from herpes infection and disease. However, the nature of protective CD8 T cells in HSV-1 seropositive healthy asymptomatic (ASYMP) individuals (with no history of clinical herpes disease) remains to be determined. In this study, we compared the phenotype and function of HSV-specific CD8 T cells from HLA-A*02:01-positive ASYMP and symptomatic (SYMP) individuals (with a documented history of numerous episodes of recurrent ocular herpetic disease). Read More
Stomatologiia (Mosk) 2018 ;97(4):16-18
Moscow State Medical Dental University Named After A.I. Evdokimov, Moscow, Russia.
Research ebjective was to study assessment of quality organization of work treatment recurrent herpetic stomatitis in patients of industrial enterprises from employees.172 patients on the industrial enterprises from 25 to 54 year were treated recurrent herpetic stomatitis. Clinical efficiency of immunomodulator quality therapy of recurrent herpetic stomatitis for assessment organization of work in employees industrial is proved by estimation of oral cavity local immunity (SIgA, lisozyme). Read More
Expert Rev Anti Infect Ther 2018 Oct 24;16(10):781-791. Epub 2018 Sep 24.
c Infectious Diseases Unit , Hospital Universitario 12 de Octubre , Madrid , Spain.
Introduction: The development of biologic therapies for treating patients with rheumatic, hematologic, or oncological diseases has increased in the last few years, spreading their use in clinical practice. Areas covered: Clinical experience has evidenced substantial risks for some viral infections and/or reactivations such as viral hepatitis, herpetic infections, and other viruses, as a consequence of specific immune pathway blockages. Biological therapies produce a variable risk of reactivation of viral infections, which is particularly uncertain in the case of the most recently introduced agents. Read More
Open Dent J 2018 31;12:520-528. Epub 2018 Jul 31.
Department of Odontostomatology, Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain.
Introduction: Orofacial pain of periodontal origin has a wide range of causes, and its high prevalence and negative effect on patients' quality of life make intervention mandatory. This review provides a periodontological overview of the field of orofacial pain, focusing on the entities which involve the periodontal tissues and may be the cause of this pain or discomfort.
Methods: The study comprised a literature search of these pathologies conducted in the MEDLINE/PubMed Database. Read More
Vaccine 2018 Nov 5;36(46):7105-7111. Epub 2018 Sep 5.
Imperial College London, UK.
Background: Herpes zoster (shingles) is a common viral disease increasing in risk and severity with age. Post-herpetic neuralgia (PHN), a complication of shingles, causes severe pain impacting quality of life (QoL). Zoster Vaccine Live (ZVL), a licensed vaccine for the prevention of shingles in the United Kingdom (UK), is part of the national immunisation programme (NIP) for adults aged 70-79. Read More
Dent Clin North Am 2018 10 14;62(4):597-609. Epub 2018 Aug 14.
Naval Postgraduate Dental School, Bethesda, MD, USA. Electronic address:
Painful oral vesiculoerosive diseases (OVD) include lichen planus, pemphigus vulgaris, mucous membrane pemphigoid, erythema multiforme, and recurrent aphthous stomatitis. OVD lesions have an immunopathic cause. Treatment is aimed at reducing the immunologic and the following inflammatory response. Read More
J Pain Res 2018 22;11:1559-1566. Epub 2018 Aug 22.
Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK,
There are currently no approved disease-modifying therapies for diabetic neuropathy, and there are only 3 US Food and Drug Administration-approved therapies (pregabalin, duloxetine, and tapentadol) for painful diabetic neuropathy. They each have moderate efficacy with adverse effects limiting optimal dose titration. There is a considerable need for new therapies for the management of painful diabetic neuropathy. Read More
Indian J Sex Transm Dis AIDS 2017 Jul-Dec;38(2):128-135
Department of Community Medicine, Government Villupuram Medical College and Hospital, Villupuram, Tamil Nadu, India.
Background: Mucocutaneous findings may be the presenting symptoms in HIV-afflicted individuals. A multitude of mucocutaneous diseases also occurs during the course of the ailment, with some conditions being classed as disease defining. They include infectious diseases and noninfective inflammatory and neoplastic dermatoses. Read More
Ocul Immunol Inflamm 2018 Aug 24:1-9. Epub 2018 Aug 24.
a Department of Ophthalmology , King Saud University , Riyadh , Saudi Arabia.
Purpose: To investigate incidence, risk factors, and surgical outcomes of cataract among uveitis patients.
Methods: Retrospective review of 1000 patients (1582 eyes).
Results: At initial presentation, cataract was diagnosed in 290 (18. Read More
Int J Ophthalmol 2018 18;11(8):1416-1420. Epub 2018 Aug 18.
Department of Ophthalmology, School of Medicine, Gyeongsang National University, Jinju 52727, South Korea.
This study is to investigate the characteristic features of Acanthamoeba keratitis (AK) that differentiating it from herpetic epithelial keratitis (HEK) using anterior segment optical coherence tomography (AS-OCT). Medical records of three eyes of each AK and herpetic keratitis who had AS-OCT examination were reviewed in this study. Slit-lamp biomicroscopy and AS-OCT was performed on the initial visit and on every follow-up visits in all patients. Read More
Hum Vaccin Immunother 2018 Aug 21:1-4. Epub 2018 Aug 21.
a Department of Medicine , Tuen Mun Hospital , Hong Kong , China.
Among the inflammatory rheumatic diseases, SLE is associated with the highest risk of herpes zoster reactivation relative to age. The reported incidence of herpes zoster infection in SLE ranges from 6.4 to 91. Read More
J Fr Ophtalmol 2018 Sep 17;41(7):e315-e318. Epub 2018 Aug 17.
Service d'ophtalmologie, hôpital universitaire Fattouma-Bourguiba, 5019 Monastir, Tunisie; Faculté de médecine, université de Monastir, 5019 Monastir, Tunisie.
J Feline Med Surg 2018 Aug 13:1098612X18789719. Epub 2018 Aug 13.
2 Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA, USA.
Objectives In humans with herpetic disease, early or pre-emptive famciclovir therapy reduces disease duration and severity. This prospective, masked, placebo-controlled study tested therapeutic and prophylactic effects of two famciclovir doses given to cats for 7 days following shelter entry. Methods Cats were assigned to prophylactic or therapeutic study arms based on clinical evidence of herpetic disease at study entry. Read More
J Clin Anesth 2018 Dec 1;51:37. Epub 2018 Aug 1.
Department of Anesthesiology, Showa University Hospital, Tokyo, Japan.
Medicine (Baltimore) 2018 Aug;97(31):e11663
Department of Ophthalmology, National Defense Medical College, Saitama.
Rationale: Chronic uveitis with immunosuppressive agents could develop chronic herpetic retinitis with varicella-zoster virus (VZV) or herpes simplex virus (HSV). Ocular Epstein-Barr virus (EBV) infection develops uveitis and vitritis, but the clinical feature of EBV retinitis is not typical as a viral retinitis. EBV retinitis is rare, and only a few cases of EBV retinitis have been reported. Read More
BMC Ophthalmol 2018 Aug 2;18(1):189. Epub 2018 Aug 2.
Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Background: The distribution of uveitis varies with genetic, ethnic, geographic, environmental, and lifestyle factors. Epidemiological information about the patterns of uveitis is useful when an ophthalmologist considers the diagnosis of uveitis. Therefore, it is important to identify the causes of uveitis over the years in different regions. Read More
Ir J Med Sci 2018 Jul 31. Epub 2018 Jul 31.
Department Orthopaedics, Tallaght University Hospital, Dublin 24, Ireland.
Objectives: Nationally, 5% of the population have been prescribed topical lidocaine patches (TLPs). These patches cost €77-230 per month. The only licensed indication for TLP is post-herpetic neuralgia (PHN). Read More
Acta Dermatovenerol Croat 2017 Dec;25(4):292-294
Mihaela Paula Toader MD, PhD, T. Popa University of Medicine and Pharmacy, Iasi, Romania, 16 Universitatii str. 700115, Iasi, Romania;
Dear Editor, Subcutaneous granuloma annulare (SGA) is considered a rare clinical variant of granuloma annulare, a common self-healing chronic inflammatory disorder that may appear in childhood as well as in adult age (1-3). A 29-year-old female patient reported the onset of several small subcutaneous nodules on the dorsal aspect of the second interphalangeal joint of the left medius finger and the left elbow, accompanied by vague joint pain, had occurred 13 years ago. Specific markers for rheumatoid arthritis were negative, leading to a diagnosis of sero-negative rheumatoid arthritis, for which treatment with methotrexate was initiated. Read More
Eur J Paediatr Dent 2018 Sep;19(3):226-232
Department of Paediatric Dentistry, Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.
Aim: The aim of this study was to estimate the prevalence of oral health problems in leukaemic paediatric patients in the United Arab Emirates (UAE) and correlate it to the phase of chemotherapy.
Materials And Methods: Medical records of 120 paediatric leukaemic patients (age below 15 years) in the UAE were reviewed for the occurrence of oral health problems. Records from the three main hospitals that provide cancer therapy were accessed after obtaining the required permissions. Read More
Ocul Immunol Inflamm 2018 Jul 30:1-9. Epub 2018 Jul 30.
a Department of Ophthalmology , Ospedale San Raffaele Scientific Institute, University Vita-Salute , Milan , Italy.
Purpose: To describe clinical features and outcome in bilateral acute retinal necrosis (BARN).
Methods: Observational retrospective longitudinal review of ocular findings.
Results: Thirty eyes of 15 patients (age 44. Read More
Br J Pain 2018 Aug 31;12(3):189-193. Epub 2018 Jan 31.
Sheffield Children's NHS Foundation Trust, Sheffield, UK.
The Lidocaine 5% plaster is licensed for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia in adult patients over 18 years of age. Studies in adults also demonstrate efficacy of Lidocaine 5% plasters in other neuropathic pain conditions. Case reports and experience suggested efficacy of Lidocaine 5% plasters in children and adolescents with localised neuropathic pain. Read More
Clinics (Sao Paulo) 2018 07 19;73:e243. Epub 2018 Jul 19.
Center for Observational & Real-World Evidence, Vaccines, Merck & Co., Inc., Kenilworth, NJ, United States.
Objectives: Herpes zoster is characterized by acute neuritis and post-herpetic neuralgia. Currently, data concerning the zoster-associated impact on quality of life and healthcare resource utilization in Brazil are scarce. This study measured the zoster-associated burden in a Brazilian population. Read More
Expert Rev Vaccines 2018 Jul 20;17(7):619-634. Epub 2018 Jul 20.
a GSK , Wavre , Belgium.
Introduction: GSK has developed a two-dose adjuvanted recombinant zoster vaccine (Shingrix, RZV) to protect people aged ≥50 years (50+) against herpes zoster (HZ) and its complications. RZV showed >90% efficacy against HZ, sustained over 4 years of follow-up, in all studied age groups. Areas covered: This article reviews the scientific rationale underlying the design of RZV; the clinical evidence demonstrating immunogenicity, safety, and efficacy in persons 50+; and the public health implications and cost-effectiveness. Read More