72,172 results match your criteria Herpes Zoster Oticus

Cost-effectiveness of varicella and herpes zoster vaccination in Sweden: An economic evaluation using a dynamic transmission model.

PLoS One 2021 13;16(5):e0251644. Epub 2021 May 13.

Department of Public Health Analysis and Data Management, Public Health Agency of Sweden, Solna, Sweden.

Objectives: Comprehensive cost-effectiveness analyses of introducing varicella and/or herpes zoster vaccination in the Swedish national vaccination programme.

Design: Cost-effectiveness analyses based on epidemiological results from a specifically developed transmission model.

Setting: National vaccination programme in Sweden, over an 85- or 20-year time horizon depending on the vaccination strategy. Read More

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Surveillance of Vaccination Coverage Among Adult Populations -United States, 2018.

MMWR Surveill Summ 2021 May 14;70(3):1-26. Epub 2021 May 14.

Problem/condition: Adults are at risk for illness, hospitalization, disability and, in some cases, death from vaccine-preventable diseases, particularly influenza and pneumococcal disease. CDC recommends vaccinations for adults on the basis of age, health conditions, prior vaccinations, and other considerations. Updated vaccination recommendations from CDC are published annually in the U. Read More

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Clinical Features and Management of Stenotrophomonas Maltophilia Keratitis.

Ophthalmol Ther 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology, Chosun University College of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju, Republic of Korea.

Introduction: Stenotrophomonas maltophilia keratitis is an uncommon infectious disease of the cornea. The clinical features, antibiotic susceptibility, and clinical outcomes of S. maltophilia keratitis were investigated in this study. Read More

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P2X7 receptor antagonist BBG inhibits endoplasmic reticulum stress and pyroptosis to alleviate postherpetic neuralgia.

Mol Cell Biochem 2021 May 12. Epub 2021 May 12.

Department of Dermatology, The First Affiliated Hospital of USTC, 17 Lujiang Road, Hefei, 230001, Anhui Province, China.

Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. The present study investigated the P2X7 receptor antagonist brilliant blue G (BBG) whether inhibits endoplasmic reticulum stress and pyroptosis (a necrotic form of cell death) and alleviates PHN. Read More

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Severe congenital chorioretinitis caused by congenital lymphocytic choriomeningitis virus infection.

Am J Ophthalmol Case Rep 2021 Jun 17;22:101094. Epub 2021 Apr 17.

Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.

Purpose: To describe a case of congenital lymphocytic choriomeningitis virus (LCMV), a potentially severe and under-diagnosed etiology of congenital chorioretinitis.

Observations: A 5-month old boy presented with esotropia. Examination revealed light perception vision in the right eye and normal fixation and following behavior in the left eye, and a 50PD esotropia with full versions. Read More

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Promoting Healthy Ageing in South Africa Through Vaccination of the Elderly.

Front Public Health 2021 26;9:635266. Epub 2021 Apr 26.

South African Vaccination and Immunisation Centre, Sefako Makgatho Health Sciences University, Pretoria, South Africa.

The World Health Organization estimates that globally, the proportion of people aged ≥60 years will more than double by the year 2050, with the majority of elderly people living in low- and middle-income countries such as South Africa. Population ageing is an impending public health concern, potentially negatively impacting on South Africa's economy and health system if the government does not adequately prepare for this change. Globally, many potential solutions to ensure healthy ageing are being discussed and implemented, including adopting a "life-course" approach to vaccination which includes vaccination of the elderly, since they are at considerable risk of severe morbidity and mortality from vaccine-preventable diseases. Read More

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Branch Retinal Vein Occlusion in a Case of Sarcoidosis.

Nepal J Ophthalmol 2021 Jan;13(25):146-151

Reiyukai Eiko Masunaga Eye Hospital, Banepa, Kavre, Nepal.

Background: Sarcoidosis is a chronic inflammatory disorder characterized by non-caseation granuloma. It is an inflammatory disorder of unknown etiology. Sarcoidosis has variable ocular presentations from anterior uveitis to rare venous occlusions. Read More

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January 2021

A bibliometric review of oncolytic virus research as a novel approach for cancer therapy.

Virol J 2021 May 12;18(1):98. Epub 2021 May 12.

Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran.

Background: In recent years, oncolytic viruses (OVs) have drawn attention as a novel therapy to various types of cancers, both in clinical and preclinical cancer studies all around the world. Consequently, researchers have been actively working on enhancing cancer therapy since the early twentieth century. This study presents a systematic review of the literature on OVs, discusses underlying research clusters and, presents future directions of OVs research. Read More

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Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells.

Immunity 2021 May 5. Epub 2021 May 5.

Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Program in Immunology, Harvard Medical School, Longwood Avenue, Boston, MA, USA. Electronic address:

Two sets of innate immune proteins detect pathogens. Pattern recognition receptors (PRRs) bind microbial products, whereas guard proteins detect virulence factor activities by the surveillance of homeostatic processes within cells. While PRRs are well known for their roles in many types of infections, the role of guard proteins in most infectious contexts remains less understood. Read More

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Herpes-Associated Erythema Multiforme.

N Engl J Med 2021 05;384(19):1848

Hospital Universitario 12 de Octubre, Madrid, Spain

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Diagnostic features of the presumed focal viral retinitis: A case series.

Anu Manandhar

Nepal J Ophthalmol 2020 Jul;12(24):339-346

Tilganga Institute of Ophthalmology, Gaushala, Kathmandu, Nepal.

Introduction: Other than well-known herpetic retinopathies like acute retinal necrosis, progressive outer retinal necrosis and cytomegalovirus retinitis, there are few reports on atypical forms of viral retinitis caused by herpes virus from around the world.

Cases: Presenting symptom was sudden onset of diminution of vision in all 6 cases. Mean duration of symptoms at presentation was 7. Read More

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Erosive pustular dermatosis after herpes zoster.

Health Sci Rep 2021 Jun 5;4(2):e277. Epub 2021 May 5.

Department of Pathology, Medical Faculty Maltepe University Istanbul Turkey.

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Acute Enterovirus Encephalitis as a Cause for Isolated Visual and Auditory Hallucinations in a 22-Year-Old Patient.

Case Rep Psychiatry 2021 23;2021:6687735. Epub 2021 Apr 23.

Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Viral encephalitis often presents with severe illness, headache, fever, behavioral changes, altered level of consciousness, and focal neurologic deficits. One of the most feared kind of virus encephalitis is herpes simplex encephalitis; however, other central virus infections are also capable of presenting with psychiatric symptoms. Here, we report the case of a 22-year-old woman with first time visual and auditory hallucinations due to an acute enterovirus encephalitis with no cerebrospinal fluid abnormalities but a positive PCR result for enterovirus (ECHO). Read More

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Combined Bacterial and Herpes Simplex Virus Keratitis following Small-Incision Lenticule Extraction for the Correction of Myopia.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):227-231. Epub 2021 Apr 12.

Department of Cornea and Refractive Surgery, Instituto de Oftalmología, Conde de Valenciana, Mexico City, Mexico.

A 28-year-old male presented unilateral visual loss, intense ocular pain, redness and intraocular hypertension in his right eye 2 days after undergoing small-incision lenticule extraction (SMILE) in both eyes. Initial examination of the affected eye revealed the presence of white infiltrates within the corneal interface, as well as a central epithelial defect. The patient was diagnosed with infectious keratitis, posteriorly the eye was irrigated with balanced saline solution and treatment was initiated with hourly moxifloxacin 0. Read More

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The Diagnostic Conundrum of Retinitis and a Pigmented Scar.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):164-168. Epub 2021 Apr 12.

Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

We report a finding of a pigmented chorioretinal scar with acute retinal necrosis (ARN) caused by herpes simplex virus 2 (HSV-2) infection rather than toxoplasma, creating an initial diagnostic dilemma. A 53-year-old functionally monocular male presented with painless floaters and blurry vision in his seeing eye over a period of 4 days. An exam demonstrated anterior chamber (AC) reaction, vitritis, multifocal patches of whitening, and an occlusive retinal vasculitis. Read More

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Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment.

mBio 2021 May 11;12(3). Epub 2021 May 11.

Department of Microbial Sciences, University of Surrey, Guildford, United Kingdom

Enveloped viruses exploit cellular trafficking pathways for their morphogenesis, providing potential scope for the development of new antiviral therapies. We have previously shown that herpes simplex virus 1 (HSV1) utilizes recycling endocytic membranes as the source of its envelope, in a process involving four Rab GTPases. To identify novel factors involved in HSV1 envelopment, we have screened a small interfering RNA (siRNA) library targeting over 80 human trafficking proteins, including coat proteins, adaptor proteins, fusion factors, fission factors, and Rab effectors. Read More

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Effectiveness and safety of cladribine in MS: Real-world experience from two tertiary centres.

Mult Scler 2021 May 12:13524585211012227. Epub 2021 May 12.

Department of Neurology and Center for Translational and Behavioral Neurosciences (C-TNBS), University Medicine Essen, Essen, Germany.

Background: Oral cladribine has been approved for the treatment of relapsing multiple sclerosis (MS) yet real-world evidence regarding its effectiveness and safety remains scarce.

Objective: To evaluate efficacy and safety outcomes of MS patients following induction of cladribine.

Methods: We evaluated our prospective cohort of cladribine-treated MS patients from two tertiary centres in Germany. Read More

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[Metastatic Pulmonary Calcification: A Rare Entity in the Differential Diagnosis Examination of Interstitial Lung Diseases].

Pneumologie 2021 May 11. Epub 2021 May 11.

Institut für diagnostische und interventionelle Radiologie, Ammerlandklinik Westerstede.

A 70-year-old patient who received a kidney transplant about 20 years ago due to anti-neutrophil cytoplasmic antibody (ANCA)-positive, rapidly progressive glomerulonephritis was assigned to us for an evaluation of fibrosing interstitial lung disease with computer tomography (CT)-radiological changes assigned to acute alveolitis. She complained about long-term exertional dyspnea. In terms of lung function, there was some slight restriction (FVC 78 % of the target), and pronounced severe diffusion disorder (DLCO 41 % of the target). Read More

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Skin Diseases in Elite Athletes.

Int J Sports Med 2021 May 11. Epub 2021 May 11.

Department of Sport Medicine Humboldt University and Charité University School of Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.

An athlete's skin has to cope with various stressors that influence skin integrity. This study investigated the effect of intense sporting activity at a competitive level on skin health, independent of the type of sport. The prevalence of dermatoses in elite athletes who exercise 8 or more hours per week was compared to recreational athletes. Read More

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Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy.

Invest Ophthalmol Vis Sci 2021 May;62(6):12

Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China.

Purpose: The purpose of this study was to investigate the limbal changes in the palisades of Vogt (POV) in patients with herpes simplex keratitis (HSK) and herpes zoster ophthalmicus (HZO) with the application of in vivo confocal microscopy (IVCM).

Methods: We enrolled 35 eyes of 35 consecutive patients with HSK and 4 patients with HZO in this observational study. Thirty-five participants were also recruited from a healthy population as the control group. Read More

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Evaluation of immunogenicity and protection mediated by Lawsonia intracellularis subunit vaccines.

Vet Immunol Immunopathol 2021 May 7;237:110256. Epub 2021 May 7.

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address:

Lawsonia intracellularis is an economically important bacterium that causes ileitis in pigs. Current vaccines for L. intracellularis do not allow for differentiation between infected and vaccinated animals (DIVA), which is beneficial for disease tracking and surveillance. Read More

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Comparative Analysis of Molecular and Serologic Testing for Primary Syphilis: A Population-Based Cohort Study.

Front Cell Infect Microbiol 2021 23;11:579660. Epub 2021 Apr 23.

Department of Medicine, University of Calgary, Calgary, AB, Canada.

Rising rates of syphilis () requires rapid diagnosis and treatment to manage the growing epidemic. Syphilis serology is imperfect and requires interpretation of multiple tests while molecular diagnostics allows for potential yes-no identification of highly infective, primary anogenital lesions. Accuracy of this testing modality has thus far been limited to small, highly selective studies. Read More

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Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer.

Oncol Lett 2021 Jun 23;21(6):490. Epub 2021 Apr 23.

Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama 641-8510, Japan.

Currently, gastric cancer is the third most common cause of cancer-associated mortality worldwide. Oncolytic virotherapy using herpes simplex virus (HSV) has emerged as a novel therapeutic strategy against cancer. Telomerase is activated in >90of malignant tumors, including gastric cancer, and human telomerase reverse transcriptase (hTERT) is one of the major components of telomerase enzyme. Read More

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Subacute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats.

Exp Ther Med 2021 Jun 15;21(6):632. Epub 2021 Apr 15.

Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, P.R. China.

As a novel heat shock protein 90 inhibitor, AT-533 exhibits various biological activities , including anti-viral, anti-tumor and anti-inflammatory activities. Moreover, AT-533 gel, a gel dosage form of AT-533, has been suggested to have anti-keratitis and herpes simplex virus type-1 infection-induced effects on the skin lesions of animals. However, the safety evaluation of AT-533 and AT-533 gel has, to the best of our knowledge, not been examined in toxicological tests. Read More

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Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response.

Front Immunol 2021 22;12:655637. Epub 2021 Apr 22.

State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation of cGAS by self-DNA promotes severe autoinflammatory diseases such as Aicardi-Goutières syndrome (AGS); thus, inhibition of cGAS may provide therapeutic benefit in anti-autoimmunity. Here we report that perillaldehyde (PAH), a natural monoterpenoid compound derived from , suppresses cytosolic-DNA-induced innate immune responses by inhibiting cGAS activity. Read More

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Assessing the Burden of Infant Deaths due to Herpes Simplex Virus, Human Immunodeficiency Virus, and Congenital Syphilis - United States, 1995-2017.

Sex Transm Dis 2021 May 6. Epub 2021 May 6.

Bureau of Sexually Transmitted Infections, New York City Department of Health and Mental Hygiene, Long Island City, NY Division of STD Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, U.S. Centers for Disease Control and Prevention, Atlanta, GA.

Background: Despite advances in diagnosis and treatment, neonatal infection with herpes simplex virus (HSV) has a high case fatality rate. The national burden of neonatal HSV, and associated deaths, is unknown because this condition is not nationally notifiable. We investigated trends in HSV-related infant deaths, compared to infant deaths from congenital syphilis (CS) and human immunodeficiency virus (HIV). Read More

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Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses.

Antiviral Res 2021 May 6:105087. Epub 2021 May 6.

National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA, 20110 USA; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Center for Zoonotic and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA. Electronic address:

Marine microorganisms have been a resource for novel therapeutic drugs for decades. In addition to anticancer drugs, the drug acyclovir, derived from a marine sponge, is FDA-approved for the treatment of human herpes simplex virus-1 infections. Most alphaviruses that are infectious to terrestrial animals and humans, such as Venezuelan and eastern equine encephalitis viruses (VEEV and EEEV), lack efficient antiviral drugs and it is imperative to develop these remedies. Read More

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Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids.

J Allergy Clin Immunol 2021 May 6. Epub 2021 May 6.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS), Technology and Research (A*STAR), Biopolis, Singapore; Lead contact. Electronic address:

Background: Epidemiological studies have yielded conflicting results regarding the influence of a single bout of prolonged high-intensity exercise on viral infection.

Objective: Here, we show that prolonged high-intensity exercise induces either exacerbation or amelioration of herpes simplex virus type 2 (HSV-2) infection depending on the interval between viral exposure and exercise.

Methods: Mice were intravaginally infected with HSV-2 and exposed to run on the treadmill. Read More

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Pediatric Autoimmune Encephalitis and Its Relationship With Infection.

Pediatr Neurol 2021 Apr 7;120:27-32. Epub 2021 Apr 7.

Department of Pediatrics, Peking University People's Hospital, Beijing, P.R. China. Electronic address:

Autoimmune encephalitis (AE) is an increasingly recognized inflammatory disorder of the central nervous system and is most often characterized by antibodies against intracellular and neuronal surface antigens. AE is a devastating disease that may result in developmental delay or regression in children. However, the pathogenesis of AE is not clear, and immune system disorders after infection likely play an important role in AE. Read More

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Adult preventive vaccines with other synergistic lifestyle options: is it time to add these ancillary benefits to the overall AS management checklist?

Mark A Moyad

World J Urol 2021 May 7. Epub 2021 May 7.

Department of Urology, University of Michigan Medical Center, Ann Arbor, MI, 48109-5330, USA.

Purpose: To review the potential ancillary cardiovascular and other health impacts of compliance with general adult vaccination series in the prostate cancer active surveillance (AS) population. No previous review has been published in regard to this specific topic.

Methods: Literature review of PubMed data up to December 2020 RESULTS: Compliance rates for adult vaccination are in the approximate anemic range of 25-50% with occasional higher rates of specific vaccines in the elderly population including annual influenza and pneumococcal prevention. Read More

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