1,742 results match your criteria Herpes Zoster Ophthalmicus


[Herpes Zoster Ophthalmicus presenting as acute headache].

Andes Pediatr 2022 Apr;93(2):270-275

Hospital Universitario Francisco de Borja, Valencia, España.

Herpes Zoster (HZ) is rare in childhood and is defined as the reactivation of the latent varicella-zoster virus in patients who have previously been infected with varicella. When the virus affects the ophthal mic nerve it is called herpes zoster ophthalmicus (HZO) and it can produce, among other symptoms, acute headache, so it must be considered as a differential diagnosis.

Objective: To describe a clinical case of HZO in a pediatric patient and to recognize its clinical manifestations and their importance in the differential diagnosis of acute headache in children. Read More

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Trigeminal extracranial thermocoagulation along with patient-controlled analgesia with esketamine for refractory postherpetic neuralgia after herpes zoster ophthalmicus: A case report.

World J Clin Cases 2022 May;10(13):4220-4225

Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China.

Background: Primary trigeminal neuralgia can achieve satisfactory results through clinical treatment and intervention. The pathogenesis of neuralgia caused by varicella-zoster virus infection of the trigeminal nerve is more complex, and it is still difficult to relieve the pain in some patients simply by drug treatment or surgical intervention.

Case Summary: A 66-year-old woman was hospitalized with herpetic neuralgia after herpes zoster ophthalmicus (varicella-zoster virus infects the ophthalmic branch of the trigeminal nerve). Read More

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A Case Report of Herpes Zoster Ophthalmicus and Meningitis After COVID-19 Vaccination.

J Korean Med Sci 2022 May 23;37(20):e165. Epub 2022 May 23.

Department of Ophthalmology, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.

There are several reports that herpes zoster characterized by reactivation of varicella zoster virus (VZV) following coronavirus disease 2019 (COVID-19) vaccines can occur. Herein, we report VZV meningitis, herpes zoster ophthalmicus (HZO), and late neurotrophic keratitis after receiving a second dose of messenger RNA (mRNA) COVID-19 vaccine. A 74-year-old man developed a vesicular skin rash on the forehead, scalp, nose, and left upper eyelid with a severe headache. Read More

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[Herpes zoster-prevention, diagnosis, and treatment].

Hautarzt 2022 Jun 27;73(6):442-451. Epub 2022 Apr 27.

Klinik für Dermatologie, Venerologie und Allergologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Background: Herpes zoster (HZ) is a common skin disease resulting from a regionally limited reactivation of a latent infection with the varicella zoster virus (VZV). Despite its usually self-limiting course, HZ is associated with a considerable individual and public health burden of disease, particularly due to its high rate of postherpetic neuralgia (PHN).

Objectives: To improve knowledge of the current recommendations for the prevention, diagnosis and treatment. Read More

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A clinically validated, broadly active, oral viral superinfection therapy could mitigate symptoms in early-stage COVID-19 patients.

Infect Disord Drug Targets 2022 Apr 19. Epub 2022 Apr 19.

DNAtrix Inc, 10355 Science Center Drive, Suite 110, San Diego, CA 92121, USA.

More than 200 viruses infect humans but drugs are available for fewer than ten. To narrow the gap between 'bugs and drugs', a paradigm shift is required. The "one drug, one bug" approach should be supplemented by the "one drug, multiple bugs" strategy such that the host is targeted rather than the virus. Read More

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Reactivation of Herpes Zoster Keratitis Following Shingrix Vaccine.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):104-108. Epub 2022 Feb 24.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA.

We present a case of herpes zoster keratitis reactivation shortly following the Shingrix vaccine. In our patient, reactivation of herpes zoster keratitis occurred a few weeks following the herpes zoster subunit (HZ/su) vaccine. The development of herpes zoster ophthalmicus following HZ/su is exceedingly rare, with only one prior reported case found in the literature. Read More

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February 2022

Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review.

J Neuroophthalmol 2022 06 25;42(2):154-162. Epub 2022 Mar 25.

Department of Neurology (IL, ML), Division of Neuroimmunology and Neuroinfectious Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; and Treadwell Virtual Library for the Massachusetts General Hospital (ML), Boston, Massachusetts.

Background: A worldwide mass vaccination campaign against the coronavirus disease 2019 (COVID-19) pandemic is currently underway. Although the safety data of the clinical trials did not report specific concerns regarding neuro-ophthalmological adverse events, they involved a limited number of individuals and were conducted over a relatively short time. The aim of the current review is to summarize the available postmarketing data regarding the occurrence of neuro-ophthalmological and other ocular complications of the COVID-19 vaccines. Read More

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Herpes Zoster Ophthalmicus Causing Delayed Optic Perineuritis.

Neurohospitalist 2022 Apr 20;12(2):417. Epub 2021 Sep 20.

Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

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Manifestation of Herpetic Eye Disease after COVID-19 Vaccine: A UK Case Series.

Ocul Immunol Inflamm 2022 Apr 12:1-6. Epub 2022 Apr 12.

Department of Ophthalmology, Queen's Medical Centre, Nottingham, UK.

Purpose: To highlight the potential risk of herpetic eye disease (HED) reactivation following COVID-19 vaccine.

Methods: Retrospective analysis of all patients who presented with HED within 28 days post-first dose COVID-19 vaccination.

Results: Eleven eyes (n = 10 patients) were included. Read More

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The Role of Nervous System and Immune System in Herpes Zoster Ophthalmicus Dissemination and Laterality - Current Views.

Ocul Immunol Inflamm 2022 Apr 12:1-9. Epub 2022 Apr 12.

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, Haidian, China.

Purpose: Herpes zoster ophthalmicus (HZO) is a sight-threatening condition that is defined as HZ involving the ophthalmic division of the trigeminal nerve. Cases of bilateral HZO in recent literature question the notion of HZO being a strictly unilateral disease. Its pathogenesis is a topic of debate and current literature on VZV dissemination lacks insight into the underlying immunology. Read More

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Abducens Nerve Palsy as a Complication of Herpes Zoster Ophthalmicus: A Case Report.

Cureus 2022 Mar 7;14(3):e22920. Epub 2022 Mar 7.

Radiology, Hamad General Hospital, Doha, QAT.

Herpes zoster (shingles) is a common viral infection that results from the reactivation of varicella-zoster virus (VZV), which remains dormant in sensory ganglia after initial infection. The usual presentation is radicular pain followed by eruption of vesicular rash. herpes zoster ophthalmicus (HZO) is defined as the involvement of ophthalmic division (V1) of the trigeminal nerve (V). Read More

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Human immune deficiency virus conundrum: An everlasting challenge!

Oman J Ophthalmol 2022 Jan-Apr;15(1):13-19. Epub 2022 Mar 2.

Department of Ophthalmology, SP Medical College, Bikaner, Rajasthan, India.

Background: Human immune deficiency virus (HIV) causes a wide spectrum of diseases worldwide and has the capability to affect every organ system in the body. Ocular manifestations have been reported in up to 70% of individuals infected with HIV and the ocular manifestations reflect systemic disease and maybe the first sign of disseminated infection.

Purpose: To study the pattern of ocular manifestations related to HIV in seropositive patients with the objective of identifying its spectrum in highly active antiretroviral therapy (HAART) era and to emphasize on the role of ophthalmologists in fighting the battle against HIV. Read More

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Recurrence of Varicella-Zoster Virus Keratitis After SARS-CoV-2 Vaccination.

Cornea 2022 May;41(5):649-650

Department of Ophthalmology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Purpose: The purpose of this study was to report a case of acute exacerbation in varicella-zoster virus (VZV) keratitis after SARS-CoV-2 vaccination.

Methods: An 87-year-old man, with a history of herpes zoster ophthalmicus 10 years ago, was referred for sudden visual impairment in his left eye that started 2 days after his second dose of SARS-CoV-2 mRNA vaccine BNT162b2.

Results: At presentation, his visual acuity was hand motion. Read More

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Orbital apex syndrome secondary to herpes zoster ophthalmicus: Clinical features and outcomes case report and systematic review.

J Clin Neurosci 2022 May 29;99:367-372. Epub 2022 Mar 29.

Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore.

Background: This study aimed to describe the clinical features of patients with orbital apex syndrome (OAS) as a complication of herpes zoster ophthalmicus (HZO) and to identify factors associated with poor visual acuity outcomes.

Methods: We performed a systematic review and retrospective analysis of the clinical characteristics and outcomes of patients with OAS secondary to HZO reported in the literature over 42 years (1978-2020).

Results: We analysed 21 cases, 20 of which were identified in the literature, together with our patient. Read More

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Clinical profile of keratitis treated within 3 months of acute COVID-19 illness at a tertiary care eye centre.

Int Ophthalmol 2022 Apr 1. Epub 2022 Apr 1.

Ocular Pathology Laboratory, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To report the spectrum of keratitis treated within 3 months of acute COVID-19 infection.

Methods: Retrospective, descriptive case series study of 19 eyes of 16 patients who presented at tertiary eye care centre in Southern India.

Results: Median age of the patients was 43(IQR 35-55. Read More

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Short-Term Prognostic Factors in Hospitalized Herpes Zoster Patients and Its Associated Cerebro-Cardiovascular Events: A Nationwide Retrospective Cohort in Japan.

Front Med (Lausanne) 2022 4;9:843809. Epub 2022 Mar 4.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.

Background: Short-term mortality and incidence of cerebrovascular and cardiovascular events (C-CVE) during hospitalization of patients with severe herpes zoster (HZ) have not been sufficiently investigated. We aimed to investigate short-term prognosis and incidence of C-CVE associated with HZ in hospitalized patients.

Methods: This retrospective cohort study from April 2016 to March 2018 included HZ inpatient cases selected from the Diagnosis Procedure Combination database-a Japanese nationwide inpatient database. Read More

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Coin-shaped corneal endothelial scar in herpes zoster ophthalmicus: a case report.

J Med Case Rep 2022 Mar 17;16(1):107. Epub 2022 Mar 17.

Department of Ophthalmology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul, 06973, Republic of Korea.

Background: Herpes zoster ophthalmicus includes a wide spectrum of lesions at the ocular surface, including epithelial, stromal, endothelial keratitis, and uveitis. Thus far, the occurrence of corneal endothelial disorder in herpes zoster ophthalmicus and the causative virus have not been confirmed, and the differential diagnosis and establishment of therapeutic strategies are challenging. Corneal endothelial coin-shaped lesions are well known to occur in cytomegalovirus-related corneal endotheliitis but have not been reported in patients with herpes zoster ophthalmicus. Read More

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Herpes Zoster Opthalmicus-Related Ophthalmoplegia: Anatomical, Pathogenetic, and Therapeutic Perspectives.

J Craniofac Surg 2022 Mar 10. Epub 2022 Mar 10.

Department of Ophthalmology, General Hospital Zadar, Zadar, Croatia Department of Otorhinolaryngology and Maxillofacial Surgery, General Hospital Zadar, Zadar, Croatia Department of Ophthalmology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.

Objective: To investigate the anatomical, pathogenetic, and pharmacological characteristics of herpes zoster ophthalmicus (HZO)-related ophthalmoplegia.

Methods: Case report-based systematic review was performed.

Results: This study included 96 patients (54 [56. Read More

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Evidence in the prevention of the recurrence of herpes simplex and herpes zoster keratitis after eye surgery.

Arch Soc Esp Oftalmol (Engl Ed) 2022 Mar 19;97(3):149-160. Epub 2022 Feb 19.

Vissum Grupo Miranza, Alicante, Spain. Electronic address:

Objective: Herpetic keratitis, either due to herpes simplex keratitis (HSK) or herpes zoster ophthalmicus (HZO), can recur after eye surgery.º Prophylaxis is postulated as necessary to avoid it. The objective of this study was to review the scientific evidence on the preventive methods used in the perioperative period in patients previously affected by HSK/HZO. Read More

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A case of herpes zoster ophthalmicus after third dose of Comirnaty (BNT162b2 mRNA) vaccine.

Dermatol Ther 2022 May 4;35(5):e15411. Epub 2022 Mar 4.

Dermatology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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Herpes Zoster Ophthalmicus: A Devastating Disease Coming Back with Vengeance or Finding Its Nemesis?

J Ophthalmic Vis Res 2022 Jan-Mar;17(1):123-129. Epub 2022 Jan 21.

Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Herpes zoster ophthalmicus is a frequent, painful, and debilitating condition caused by the reactivation of the varicella-zoster virus alongside the ophthalmic branch of the trigeminal nerve. Twenty-five percent of adults will develop the disease during their lifetime with the risk increasing to one in two over the age of 50. Herpes zoster ophthalmicus presents with a plethora of ocular manifestations ranging from the characteristic rash in the distribution of the ophthalmic branch of the fifth cranial nerve to more severe keratouveitis, disciform keratitis, and even retinal necrosis. Read More

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January 2022

Safety of JAK inhibitor use in patients with rheumatoid arthritis who developed herpes zoster after receiving JAK inhibitors.

Clin Rheumatol 2022 Jun 14;41(6):1659-1663. Epub 2022 Feb 14.

Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Introduction: To determine the safety of Janus kinase inhibitor (JAKi) use following herpes zoster (HZ) reactivation in patients with rheumatoid arthritis (RA).

Methods: Medical records of all patients who received JAKi at a tertiary referral center between August 2015 and June 2021 were retrospectively reviewed. Data from patients who developed HZ reactivation were collected, and the HZ-related safety of those who continued JAKis after reactivation was evaluated. Read More

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Management of Cavernous Sinus Thrombosis Following Herpes Zoster Ophthalmicus.

Cureus 2022 Jan 8;14(1):e21036. Epub 2022 Jan 8.

Department of Neurology, University of Florida College of Medicine, Gainesville, USA.

Herpes zoster opthalmicus (HZO) is the reactivation of latent varicella zoster virus (VZV) within the ophthalmic branch of the trigeminal ganglion (V1). Common complications are postherpetic neuralgia and vasculopathy. Here, we report a rare case of a 47-year-old female presenting with HZO and aseptic cavernous sinus thrombosis (CST). Read More

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January 2022

Ocular adverse events associated with chimeric antigen receptor T-cell therapy: a case series and review.

Br J Ophthalmol 2022 Feb 10. Epub 2022 Feb 10.

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

Background/aims: Chimeric antigen receptor T-cell (CAR T) therapy has been shown to improve the remission rate and survival for patients with refractory haematological malignancies. The aim of this study is to describe ocular adverse effects associated with CAR T therapy in patients with haematological malignancies.

Methods: This is a retrospective, single-institution, case series. Read More

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February 2022

Neurotrophic Keratopathy After Herpes Zoster Ophthalmicus.

Cornea 2022 Feb 5. Epub 2022 Feb 5.

Department of Ophthalmology, University of Auckland, Auckland, New Zealand.

Purpose: The aim of this study was to describe risk factors for neurotrophic keratopathy (NK) after herpes zoster ophthalmicus (HZO).

Methods: This study was a retrospective review of all patients seen at the Auckland District Health Board with HZO from 2006 through 2016. Cox proportional hazards analysis was performed to examine time to development of neurotrophic keratitis. Read More

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February 2022

Initial outcomes of mitomycin intravascular chemoembolization (MICE) for corneal neovascularization.

Int Ophthalmol 2022 Jan 31. Epub 2022 Jan 31.

Coastal Eye Clinic, New Bern, NC, USA.

Purpose: To report on the preliminary outcomes of mitomycin C (MMC) intravascular chemoembolization (MICE) for corneal neovascularization (NV).

Methods: This is a retrospective case series of three consecutive eyes that underwent MICE for progressive corneal NV with sight threatening lipid keratopathy. A 1. Read More

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January 2022

Covid-19 vaccination and possible link to Herpes zoster.

Am J Ophthalmol Case Rep 2022 Mar 26;25:101359. Epub 2022 Jan 26.

NYU Langone Medical Center: NYU Langone Health, United States.

Purpose: To report 3 otherwise healthy patients with Herpes zoster reactivation shortly after administration of a mRNA vaccine against the novel COVID-19 virus.

Observations: Patient 1 is a 54 year old who presented with Herpes zoster meningitis complicated by enhancing nodular leptomeningeal lesions of the spinal cord. The subsequent two patients had Herpes zoster ophthalmicus of the cornea (Case 2) and eyelid (Case 3). Read More

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Zoster Eye Disease Study: Rationale and Design.

Cornea 2022 May;41(5):562-571

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD.

Purpose: The purpose of this study was to describe the rationale and design of the Zoster Eye Disease Study (ZEDS).

Methods: ZEDS is a National Eye Institute-supported randomized clinical trial designed to determine whether 1 year of suppressive valacyclovir in patients with herpes zoster ophthalmicus (HZO) reduces complications because there is currently no high-quality evidence to support its use. Eligible patients are 18 years and older, immunocompetent, have a history of a typical rash at disease onset, and have had a record of active epithelial or stromal keratitis or iritis within 1 year before enrollment. Read More

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Response to comment on: Central retinal vein occlusion secondary to varicella-zoster retinal vasculitis in an immunocompetent individual during the COVID-19 pandemic - A case report.

Indian J Ophthalmol 2022 02;70(2):705-706

Department of Ophthalmology, Kasturba Medical College- Manipal, Manipal Academy of Higher Education, Madhavnagar, Manipal, Udupi District, Karnataka, India.

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February 2022

Comment on: Central retinal vein occlusion secondary to varicella-zoster retinal vasculitis in an immunocompetent individual during the COVID-19 pandemic - A case report.

Indian J Ophthalmol 2022 02;70(2):704-705

Consultant Cataract, Pediatric Ophthalmology and Strabismus Services, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, India.

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February 2022