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    The risk of herpes zoster in patients with ankylosing spondylitis: Analysis of the Korean National Health Insurance Service - Sample cohort database.
    Mod Rheumatol 2017 May 26:1-6. Epub 2017 May 26.
    c Division of Rheumatology, Department of Internal Medicine , University of Ulsan College of Medicine, Asan Medical Center , Seoul , Republic of Korea.
    Objectives: The aims of our study were to determine whether the use of conventional disease-modifying antirheumatic drugs (cDMARDs) or tumor necrosis factor α (TNFα) inhibitors increase the risk of herpes zoster (HZ) in patients with ankylosing spondylitis (AS).

    Methods: We searched the South Korean National Health Insurance Service - National Sample Cohort Database for relevant patient records between 2002 and 2013. We evaluated the incidence of HZ by categorizing patients into in three treatment groups: disease-modifying antirheumatic drug (DMARD) nonusers, cDMARD users and TNFα inhibitor users. Read More

    The natural history of varicella zoster virus infection in Norway: Further insights on exogenous boosting and progressive immunity to herpes zoster.
    PLoS One 2017 18;12(5):e0176845. Epub 2017 May 18.
    Department of Economics and Management, University of Pisa, Pisa, Italy.
    We use age-structured models for VZV transmission and reactivation to reconstruct the natural history of VZV in Norway based on available pre-vaccination serological data, contact matrices, and herpes zoster incidence data. Depending on the hypotheses on contact and transmission patterns, the basic reproduction number of varicella in Norway ranges between 3.7 and 5. Read More

    Herpes zoster - typical and atypical presentations.
    Postgrad Med 2017 May 25. Epub 2017 May 25.
    b Department of Family Medicine and Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
    Varicella- zoster virus infection is an intriguing medical entity that involves many medical specialties including infectious diseases, immunology, dermatology, and neurology. It can affect patients from early childhood to old age. Its treatment requires expertise in pain management and psychological support. Read More

    Association of serum Ninjurin2 levels with neurologic damage and postherpetic neuralgia occurrence: an observational cohort study in Chinese herpeszoster patients.
    Oncotarget 2017 May 4. Epub 2017 May 4.
    Department of Pain Management, Qilu Hospital of Shandong University, Jinan, Shandong, China.
    Objectives: Postherpetic neuralgia(PHN) is the most common complication of herpeszoster (HZ) infection. The study aimed to explore whether serum Ninjurin2 (for nerve injury-induced protein 2, NINJ2), a novel neurologic damage related protein, is associated with nerve injury and the occurrence of PHN.

    Results: Seventy-four of the eighty patients completed the study. Read More

    A case of acyclovir neurotoxicity presenting with atypical cerebrospinal fluid findings.
    BMJ Case Rep 2017 May 22;2017. Epub 2017 May 22.
    Internal Medicine, Western Michigan University School of Medicine, Kalamazoo, Michigan, USA.
    An 82-year-old man with a history of end-stage renal disease presented with progressively worsening confusion and somnolence for the past 4-5 days. The patient was diagnosed with herpes zoster by his primary care physician 5 days ago and was started on a course of valacyclovir 1 g three times a day (dose not adjusted for renal impairment).A lumbar puncture was performed and cerebrospinal fluid (CSF) studies revealed 37 white blood cells (WBCs)/hpf (100% monocytes), protein 64 mg/dL and glucose 52 mg/dL. Read More

    Preventing herpes zoster through vaccination: New developments.
    Cleve Clin J Med 2017 May;84(5):359-366
    Director, Center for Value-Based Care Research, and Vice-Chair, Research, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
    Herpes zoster (HZ) affects 1 million Americans every year. The disease burden is higher in immunocompromised patients. The live-attenuated HZ vaccine is effective in preventing HZ and postherpetic neuralgia and has been recommended for immunocompetent adults age 60 and older. Read More

    Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events.
    Acta Neurol Belg 2017 May 20. Epub 2017 May 20.
    Department of Neurology, Medical School, UNIMES, Universidade Metropolitana de Santos, Avenida Conselheiro Nebias 536, Santos, SP, CEP 11045-002, Brazil.
    Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. Read More

    Advances in the Development of Janus Kinase Inhibitors in Inflammatory Bowel Disease: Future Prospects.
    Drugs 2017 May 18. Epub 2017 May 18.
    University Hospital of Saint-Etienne, Avenue Albert Raimond, 42277, Saint Priest en Jarez, France.
    Inflammatory bowel disease (IBD) is caused by a dysregulation of the immune system, inducing the production of proinflammatory cytokines and adhesion molecules. A better understanding of the mucosal immune response in IBD has led to the development of new drugs directed at inflammatory cytokines and leukocyte-trafficking molecules. Beyond tumor necrosis factor antagonists and anti-integrin molecules, which act by blocking the interaction between gut-specific lymphocytes and their receptor on vascular endothelium, the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway represents a new target in IBD. Read More

    The need for better preventative strategies for inflammatory bowel disease patients at risk of herpes zoster virus.
    Intern Med J 2017 May 17. Epub 2017 May 17.
    Department of Gastroenterology and Hepatology, St Vincent's Hospital Sydney, NSW, Australia.
    Background: Immunosuppressed IBD patients have an increased risk of HZV infection. The existing live-attenuated HZV vaccine is contraindicated in some of these patients and can only be used with caution in others.

    Aims: To describe characteristics of IBD patients suffering HZV to enable implementation of risk mitigation strategies for those at highest risk. Read More

    Sex differences underlying orofacial varicella zoster associated pain in rats.
    BMC Neurol 2017 May 17;17(1):95. Epub 2017 May 17.
    Department of Biomedical Sciences, Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX, 75246, USA.
    Background: Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (HZ) or "shingles". Often VZV infects neurons of the trigeminal ganglia to cause ocular problems, orofacial disease and occasionally a chronic pain condition termed post-herpetic neuralgia (PHN). Read More

    Duration of Antiviral Prophylaxis and Risk of Herpes Zoster among Patients Receiving Autologous Hematopoietic Stem Cell Transplants: A Retrospective, Observational Study.
    Adv Ther 2017 May 15. Epub 2017 May 15.
    Center for Observational and Real-World Evidence, Merck and Co., Inc., Kenilworth, NJ, USA.
    Introduction: There are no real-world data on antiviral prophylaxis (AP) duration and risk of herpes zoster (HZ) given AP duration in patients receiving autologous hematopoietic stem cell transplants (auto-HSCT). The objectives of this study are to describe the duration of AP and to compare incidence of HZ by AP duration in auto-HSCT patients.

    Methods: This is a retrospective, observational database (Marketscan(®)) study. Read More

    Metabolic Phenotypes of Response to Vaccination in Humans.
    Cell 2017 May 11;169(5):862-877.e17. Epub 2017 May 11.
    Emory Vaccine Center, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology, School of Medicine, Emory University, Atlanta, GA 30329, USA. Electronic address:
    Herpes zoster (shingles) causes significant morbidity in immune compromised hosts and older adults. Whereas a vaccine is available for prevention of shingles, its efficacy declines with age. To help to understand the mechanisms driving vaccinal responses, we constructed a multiscale, multifactorial response network (MMRN) of immunity in healthy young and older adults immunized with the live attenuated shingles vaccine Zostavax. Read More

    Acute retinal necrosis: presenting characteristics and clinical outcomes in a cohort of polymerase chain reaction-positive patients.
    Am J Ophthalmol 2017 May 10. Epub 2017 May 10.
    Johns Hopkins University School of Medicine, The Wilmer Eye Institute, 733 North Broadway, Baltimore, Maryland; Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 North Wolfe Street, Baltimore, Maryland.
    Purpose: To identify determinants of adverse outcomes in acute retinal necrosis (ARN), presenting characteristics and incidence rates of vision loss and ocular complications in a cohort of polymerase chain reaction (PCR)-positive eyes were analyzed.

    Design: Retrospective, observational cohort study.

    Methods: Forty-one eyes of 36 patients with clinically-diagnosed ARN, PCR-positive for herpes simplex virus or varicella zoster virus and evaluated between January 2002 and June 2013, were included. Read More

    Risk of Stroke/Transient Ischemic Attack or Myocardial Infarction with Herpes Zoster: A Systematic Review and Meta-Analysis.
    J Stroke Cerebrovasc Dis 2017 May 10. Epub 2017 May 10.
    Department of Public Health, Shantou University Medical College, Shantou, Guangdong, China. Electronic address:
    Background: Accumulating evidence indicates that herpes zoster (HZ) may increase the risk of stroke/transient ischemic attack (TIA) or myocardial infarction (MI), but the results are inconsistent. We aim to explore the relationship between HZ and risk of stroke/TIA or MI and between herpes zoster ophthalmicus (HZO) and stroke.

    Methods: We estimated the relative risk (RR) and 95% confidence intervals (CIs) with the meta-analysis. Read More

    Acute urinary retention and constipation precipitated by herpes zoster infection.
    BMJ Case Rep 2017 May 12;2017. Epub 2017 May 12.
    Department of Urology, Galway University Hospitals, Galway, Ireland.
    A 76-year-old man presented to the emergency department complaining of acute urinary retention (AUR) and severe constipation. His recent medical history included 4 days of treatment in the community for gluteal herpes zoster with famciclovir. A transurethral catheter was passed and the patient completed a full course of famciclovir with resolution of constipation. Read More

    Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review.
    J Ethnopharmacol 2017 May 8. Epub 2017 May 8.
    Pharmacy, School of Medicine, University of Tasmania, 7001 Hobart, Tasmania, Australia.
    Ethnopharmacological Relevance: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. Read More

    Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study.
    Open Forum Infect Dis 2017 22;4(2):ofx050. Epub 2017 Mar 22.
    University of Alabama at Birmingham.
    Background: Infection is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Our object was to better define the epidemiology and outcomes of infections after HCT.

    Methods: This was a prospective, multicenter cohort study of HCT recipients and conducted from 2006 to 2011. Read More

    Herpes virus seroepidemiology in the adult Swedish population.
    Immun Ageing 2017 10;14:10. Epub 2017 May 10.
    Department of Clinical Microbiology, Virology, Umeå University, Umeå, Sweden.
    Background: Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex type 1 (HSV1), Herpes simplex type 2 (HSV2), Cytomegalovirus (CMV), Varicella Zoster virus (VZV) and Human herpes virus type 6 (HHV6) in an adult Swedish population (35-95 years of age).

    Methods: Presence of antibodies against the respective viruses in serum from individuals in the Betula study was determined with an enzyme-linked immunosorbent assay (ELISA). Read More

    A case control study on family history as a risk factor for herpes zoster and associated outcomes, Beijing, China.
    BMC Infect Dis 2017 May 9;17(1):334. Epub 2017 May 9.
    Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Background: Hospital-based case control studies have found family history of herpes zoster (HZ) was associated with risk of HZ, but the role of family history is not fully examined for other HZ-associated outcomes such as recurrent HZ, occurrence of postherpetic neuralgia (PHN), and HZ with different pain severities.

    Methods: We conducted a population-based matched case control study. HZ cases that occurred during December 1, 2011 to November 30, 2012 were identified by face-to-face interview with all residents of eight selected communities/villages from three districts of Beijing, China. Read More

    Vaccine profile of herpes zoster (HZ/su) subunit vaccine.
    Expert Rev Vaccines 2017 May 19:1-10. Epub 2017 May 19.
    b Genocea Biosciences, Inc ., Cambridge , MA , USA.
    Introduction: Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-related or other causes of decreased T cell immunity. A live attenuated vaccine boosts this immunity and provides partial protection against HZ, but this decreases with age and declines over 8 years. Read More

    A Trivalent Subunit Antigen Glycoprotein Vaccine as Immunotherapy for Genital Herpes in the Guinea Pig Genital Infection Model.
    Hum Vaccin Immunother 2017 May 8. Epub 2017 May 8.
    a Infectious Disease Division, Department of Medicine , Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania , United States of America.
    An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease. Some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. A vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (VZV), a closely related member of the Herpesviridae family. Read More

    Herpes zoster vaccine: A health economic evaluation for Switzerland.
    Hum Vaccin Immunother 2017 May 8:1-10. Epub 2017 May 8.
    a University of Basel, Institute of Pharmaceutical Medicine (ECPM) , Basel , Switzerland.
    Herpes zoster (HZ) or "shingles" results from a reactivation of the varicella zoster virus (VZV) acquired during primary infection (chickenpox) and surviving in the dorsal root ganglia. In about 20% of cases, a complication occurs, known as post-herpetic neuralgia (PHN). A live attenuated vaccine against VZV is available for the prevention of HZ and subsequent PHN. Read More

    Herpes Zoster and Recurrent Herpes Zoster.
    Open Forum Infect Dis 2017 28;4(1):ofx007. Epub 2017 Jan 28.
    Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
    Background: The incidence of recurrent herpes zoster (HZ) and the relationship between initial and recurrent HZ are not clear.

    Methods: The Miyazaki Dermatologist Society has surveyed ~5000 patients with HZ annually since 1997. A questionnaire regarding HZ and its recurrence was completed by the dermatologists. Read More

    Cost-effectiveness of varicella vaccine against herpes zoster and post-herpetic neuralgia for elderly in Japan.
    Vaccine 2017 May 4;35(24):3264-3271. Epub 2017 May 4.
    Department of Health Care Policy and Health Economics, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennoudai, Tsukuba, Ibaraki 3058577, Japan.
    Background: The extended use of varicella vaccine in adults aged 50 and older against herpes zoster (HZ) was recently approved in Japan, which has raised the need to evaluate its value for money.

    Methods: We conducted a cost-effectiveness analysis with Markov modelling to evaluate the efficiency of varicella vaccine immunisation programme for the elderly in Japan. Four strategies with different ages to receive a shot of vaccine were set, namely: (1) 65-84, (2) 70-84, (3) 75-84 and (4) 80-84years old (y. Read More

    Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis.
    PLoS One 2017 4;12(5):e0177057. Epub 2017 May 4.
    Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
    Objective: We evaluated the efficacy and safety of tofacitinib in patients with rheumatoid arthritis (RA) in a real-world setting.

    Methods: Seventy consecutive patients, for whom tofacitinib was initiated between November 2013 and May 2016, were enrolled. All patients fulfilled the 2010 ACR/EULAR classification criteria for RA. Read More

    Surveillance of Vaccination Coverage among Adult Populations - United States, 2015.
    MMWR Surveill Summ 2017 May 5;66(11):1-28. Epub 2017 May 5.
    Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC.
    Problem/condition: Overall, the prevalence of illness attributable to vaccine-preventable diseases is greater among adults than among children. Adults are recommended to receive vaccinations based on their age, underlying medical conditions, lifestyle, prior vaccinations, and other considerations. Updated vaccination recommendations from CDC are published annually in the U. Read More

    Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China.
    AIDS Res Ther 2017 2;14:24. Epub 2017 May 2.
    Basic Medical College of Wuhan University, Wuhan, China.
    Background: CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. Read More

    [Efficacy and safety of CTD and PCD regimens in treatment of patients with newly diagnosed multiple myeloma].
    Zhonghua Xue Ye Xue Za Zhi 2017 Apr;38(4):279-284
    Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.
    Objective: To observe the efficacy and safety of CTD (cyclophosphamide, thalidomide, dexamethasone) and PCD (bortezomib, cyclophosphamide, dexamethasone) regimens in treatment of patients with newly diagnosed multiple myeloma (NDMM) . Methods: A retrospective analysis was carried out on 88 cases of NDMM patients admitted to our hospital from July 2013 to January 2016, including 49 cases in CTD group and 39 cases in PCD group. The outcomes of two different regimens were analyzed, including response, prognosis, and adverse events. Read More

    Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis.
    N Engl J Med 2017 05;376(18):1723-1736
    From the Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla (W.J.S.); Pfizer, Collegeville, PA (C.S., W.N., G.F., N.L., D.Y., D.W., H.Z.); Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York (B.E.S.); the Department of Gastroenterology, Academic Medical Center, Amsterdam (G.R.D.); the Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium (S.V.); Department of Internal Medicine I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany (S.S.); the Inflammatory Bowel Disease Center, Department of Gastroenterology, Humanitas Research Hospital, Rozzano, Milan (S.D.); Robarts Clinical Trials, Robarts Research Institute, Western University, London (B.G.F.), and McMaster University, Hamilton (W.R.) - both in Ontario, Canada; Pfizer, Groton, CT (A.M., P.H.); and the Networking Biomedical Research Center on Hepatic and Digestive Diseases (CIBERehd), August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Clínic de Barcelona, Barcelona (J.P.).
    Background: Tofacitinib, an oral, small-molecule Janus kinase inhibitor, was shown to have potential efficacy as induction therapy for ulcerative colitis in a phase 2 trial. We further evaluated the efficacy of tofacitinib as induction and maintenance therapy.

    Methods: We conducted three phase 3, randomized, double-blind, placebo-controlled trials of tofacitinib therapy in adults with ulcerative colitis. Read More

    Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation.
    Vox Sang 2017 May 2. Epub 2017 May 2.
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
    Background And Objectives: Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. Infections during lymphopenia after allogeneic HSCT are associated with high mortality and morbidity. Typical infectious agents are Epstein-Barr virus, cytomegalovirus, herpes simplex virus, varicella-zoster virus and fungi. Read More

    Herpes zoster risk after 21 specific cancers: population-based case-control study.
    Br J Cancer 2017 May 2. Epub 2017 May 2.
    Department of Non-Communicable Diseases Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
    Background: Some malignancies are known to be associated with increased risk of herpes zoster, but little is known about how associations between cancer and subsequent zoster risk vary by cancer site, by time since cancer diagnosis, and by age.

    Methods: An age-, sex-, calendar time-, and practice-matched case-control study, nested in the broadly UK representative Clinical Practice Research Datalink (CPRD) primary care database, was analysed using conditional logistic regression to estimate the association between 21 of the most common specific malignancies and subsequent zoster risk. We adjusted for comorbid conditions and other potential confounders, and investigated effect modification by age and time since malignancy diagnosis. Read More

    Altered axonal excitability properties in facial palsy.
    Muscle Nerve 2017 Apr 29. Epub 2017 Apr 29.
    Prince of Wales Clinical School, University of New South Wales, Randwick, New South Wales, 2031, Australia.
    Introduction: Axonal excitability measures give insight into the biophysical properties of peripheral nerve axons. In this study we applied these techniques to the study of facial palsy.

    Methods: Thirty patients with established facial palsy due to unresolved Bell's palsy or herpes zoster (>6 months duration), tumor invasion of the facial nerve, or traumatic facial nerve injury were assessed using facial nerve excitability techniques. Read More

    Improving adult immunization equity: Where do the published research literature and existing resources lead?
    Vaccine 2017 May 26;35(23):3020-3025. Epub 2017 Apr 26.
    Hofstra Northwell School of Medicine, United States.
    Evidence suggests that disparities in adult immunization (AI) rates are growing. Providers need adequate patient resources and information about successful interventions to help them engage in effective practices to reduce AI disparities. The primary purposes of this paper were to review and summarize the evidence base regarding interventions to reduce AI disparities and to scan for relevant resources that could support providers in their AI efforts to specifically target disparities. Read More

    Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.
    Antiviral Res 2017 Jul 25;143:262-268. Epub 2017 Apr 25.
    Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
    Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. In this work, we report the synthesis and antiviral evaluation of phosphonoamidate and diamidates prodrugs of C5-pyrimidine acyclic nucleosides derivatives functionalized with but-2-enyl- chain. In the phosphonoamidate series, the most active compound 15, showed sub-micromolar activity against varicella zoster virus (VZV) (EC50 = 0. Read More

    Epidemiological surveillance of herpes viral encephalitis in Cordoba, Colombia.
    Rev Salud Publica (Bogota) 2016 Aug;18(4):581-591
    University of São Paulo, Brazil.
    Objective To establish an epidemiological surveillance of viral herpes encephalitis in major hospitals of Monteria, Cordoba. Methods From September 2009 to December 2011, a descriptive study of cases of viral encephalitis was made in three hospitals in the city of Monteria. Cerebrospinal fluid (CSF) samples from 118 patients were included in the study. Read More

    Receipt of thyroid hormone deficiency treatment and risk of herpes zoster.
    Int J Infect Dis 2017 Apr 24;59:90-95. Epub 2017 Apr 24.
    Department of Research and Evaluation, Kaiser Permanente Research, 100 S. Los Robles Ave, 2nd Floor, Pasadena, CA 91101, USA. Electronic address:
    Objective: Thyroid hormone (TH) has been suggested to control herpes virus gene expression and replication in neurons via epigenetics through its nuclear receptors. It has previously been shown that patients with hypothyroidism are predisposed to herpes zoster (HZ), suggesting that the TH deficiency may be a risk factor for varicella zoster virus (VZV) reactivation. The aim of this study was to test the hypothesis that TH treatment will ameliorate the complication of HZ. Read More

    Disarming Cellular Alarm Systems-Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses.
    Front Immunol 2017 11;8:390. Epub 2017 Apr 11.
    Faculty of Medicine, The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
    The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling infected cells to evade immune recognition and thereby maintain infection. The herpesvirus family consists of nine viruses that are capable of infecting humans: herpes simplex virus 1 and 2 (HSV-1, HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), roseoloviruses (HHV-6A, HHV-6B, and HHV-7), and Kaposi's-sarcoma-associated herpesvirus (KSHV). Read More

    Study of clinical profile of herpes zoster in human immunodeficiency virus positive and negative patients at a rural-based tertiary care center, Gujarat.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):65-68
    Department of Dermatology, Shree Krishna Hospital, Karamsad, Gujarat, India.
    Background: Herpes zoster usually presents with typically grouped vesicles on erythematous base involving single dermatome with self-limiting nature in immunocompetent individuals while it may present in extensive form involving multiple dermatomes involvement or disseminated form in immunocompromised, especially in human immunodeficiency virus (HIV).

    Aims And Objectives: The aim of this study was to study the prevalence of HIV in patients of herpes zoster, to compare the clinical presentation of herpes zoster in HIV-infected and noninfected patient.

    Materials And Methods: The study was carried out in the Department of Dermatology in a Teaching Institute of Gujarat, from June 2008 to May 2014 after ethical clearance. Read More

    Managing herpes zoster in older adults: Prescribing considerations.
    Nurse Pract 2017 Jun;42(6):24-29
    Linda Beuscher is an assistant professor at Vanderbilt University School of Nursing, Nashville, Tenn. Geri Reeves is an assistant professor at Vanderbilt University School of Nursing, Nashville, Tenn. Debbie Harrell is a clinical pharmacist, geriatric service at Vanderbilt University Medical Center, Nashville, Tenn.
    NPs must be aware of special prescribing considerations for medication safety when managing the care of older adults with herpes zoster. Age-related physiologic changes of the body impact the pharmacokinetics and pharmacodynamics of antiviral and pain medications and can lead to potential adverse events. Read More

    Efficacy and safety of baricitinib in Japanese patients with active rheumatoid arthritis: A 52-week, randomized, single-blind, extension study.
    Mod Rheumatol 2017 Apr 25:1-10. Epub 2017 Apr 25.
    c Eli Lilly and Company , Indianapolis , IN , USA.
    Objectives: The objective of this study is to evaluate the efficacy and safety of long-term (64 weeks; 52-week extension of a 12-week study) baricitinib treatment in Japanese patients with active rheumatoid arthritis (RA) despite methotrexate therapy.

    Methods: Patients (N = 145) with active RA were randomized to placebo, 1mg, 2mg, 4mg, or 8mg baricitinib for the first 12 weeks. During the 52-week extension period, patients on 4mg or 8mg baricitinib remained on the same dose and all other patients were re-randomized to 4mg or 8mg baricitinib. Read More

    Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox.
    Sci Rep 2017 Apr 24;7(1):1077. Epub 2017 Apr 24.
    Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
    Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. Read More

    Viral aetiologies of acute encephalitis in a hospital-based South Asian population.
    BMC Infect Dis 2017 Apr 24;17(1):303. Epub 2017 Apr 24.
    Department of Clinical Medicine, Faculty of Medicine - University of Colombo, 25, Kynsey Road, Colombo, 00800, Sri Lanka.
    Background: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population.

    Methods: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Read More

    Herpes zoster keratitis development after acute retinal necrosis.
    Int Ophthalmol 2017 Apr 22. Epub 2017 Apr 22.
    Cleveland Clinic Foundation, Cole Eye Institute, 9500 Euclid Avenue Mail Code i13, Cleveland, OH, 44195, USA.
    Purpose: To report a case of herpes zoster keratitis in a patient undergoing treatment for herpetic acute retinal necrosis.

    Methods: Case report.

    Results: A 71 year old male presented with acute retinal necrosis of the left eye due to herpes zoster and was treated with intravitreal foscarnet and oral valcyclovir. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    Comparison of immunization rates of adults ages 65 years and older managed within two nurse practitioner-owned clinics with national immunization rates.
    J Am Assoc Nurse Pract 2017 Apr 21. Epub 2017 Apr 21.
    School of Nursing and Health Sciences, Simmons College, Boston, Massachusetts.
    Background And Purpose: Adults ages ≥65 years are at increased risk for infectious diseases. Ensuring these individuals are fully vaccinated is imperative. The purpose of this study was to assess the immunization rates of adults ages ≥65 years managed by nurse practitioners (NPs) and compare the results with national immunization rates and Healthy People 2020 goals. Read More

    A critical appraisal of 'Shingrix', a novel Herpes Zoster Subunit (HZ/Su or GSK1437173A) vaccine for Varicella Zoster Virus.
    Hum Vaccin Immunother 2017 Apr 20. Epub 2017 Apr 20.
    c University College London , London , United Kingdom.
    HZ/Su, branded as 'Shingrix', is one of the newest vaccines to be submitted for multi-national regulatory approval. It is targeted to prevent shingles, predominantly affecting the elderly, but a global concern with ageing populations and significant associated morbidity and mortality. A vaccine for shingles has been available for over a decade, however it is contraindicated in specific subgroups of people, and there are added concerns regarding long-term immunogenicity. Read More

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