Semin Arthritis Rheum 2022 Apr 28;55:152019. Epub 2022 Apr 28.
Division of Rheumatology Department of Internal Medicine, Seoul National University Bundang Hospital, 166 Gumiro Bundang-gu Seongnam-si Kyeongki-do, Seongnam, Korea; Division of Rheumatology Department of Internal Medicine, Seoul National University College of Medicine, Seongnam, Korea. Electronic address:
Background: To compare infectious risk between leflunomide versus TNF inhibitors (TNFi), and between tacrolimus versus TNFi among rheumatoid arthritis (RA) patients receiving methotrexate (MTX).
Methods: Using Korea National Health Insurance Service database, we conducted a cohort study on RA patients initiating TNFi, leflunomide, or tacrolimus. The primary outcome was any serious infections defined as a composite endpoint of serious bacterial, opportunistic, and herpes zoster infections. Read More