16,476 results match your criteria Herpes Zoster


Summary of the NACI Update on Herpes Zoster Vaccines.

Can Commun Dis Rep 2018 Sep 6;44(9):220-225. Epub 2018 Sep 6.

Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Background: Steep increases in herpes zoster (HZ) incidence, hospitalization due to HZ and the risk of post-herpetic neuralgia as a complication of HZ occur in people over 50 years of age. Two HZ vaccines are currently authorized for use in those 50 years of age and older in Canada: a live attenuated zoster vaccine (LZV) authorized in 2008; and a recombinant subunit vaccine (RZV) authorized in October 2017.

Objectives: To review current evidence and develop guidance on whether the previously authorized LZV (Zostavax) and/or the recently authorized RZV (Shingrix) vaccine should be offered to Canadians 50 years of age and older: 1) at a population-level, in publicly funded immunization programs; and 2) at an individual-level, to individuals wishing to prevent HZ, or by clinicians wishing to advise individual patients about preventing HZ. Read More

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http://dx.doi.org/10.14745/ccdr.v44i09a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449089PMC
September 2018

Does Herpes Zoster Increase the Risk of Stroke and Myocardial Infarction? A Comprehensive Review.

J Clin Med 2019 Apr 22;8(4). Epub 2019 Apr 22.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Herpes zoster (HZ) caused by varicella zoster virus (VZV) reactivation is characterized as a vesicular rash of unilateral distribution that can also cause multiple complications; such as post-herpetic neuralgia; ophthalmic zoster; and other neurological issues. VZV can also increase incident hemorrhagic or ischemic complications by causing inflammatory vasculopathy. Thus; emerging epidemiological and clinical data recognizes an association between HZ and subsequent acute strokes or myocardial infarction (MI). Read More

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http://dx.doi.org/10.3390/jcm8040547DOI Listing

Trends in varicella and herpes zoster epidemiology before and after the implementation of universal one-dose varicella vaccination over one decade in South Korea, 2003-2015.

Hum Vaccin Immunother 2019 Apr 22. Epub 2019 Apr 22.

b Vaccine Bio Research Institute, College of Medicine , The Catholic University of Korea , Seoul , Republic of Korea.

Background In South Korea, one-dose varicella vaccine was included in the National Immunization Program for children aged 12-15 months in 2005, and the vaccine coverage reached >95%. The impact of varicella vaccination on varicella and herpes zoster (HZ) was investigated, accounting for demographic changes over time. Methods We calculated the crude and age-sex standardized incidence rates (IRs) and age-specific IRs of varicella and HZ from 2003 to 2015, using the National Health Information Database including approximately 50 million Koreans. Read More

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http://dx.doi.org/10.1080/21645515.2019.1603985DOI Listing

Herpes Virus Infections Other than Cytomegalovirus in the Recipients of Hematopoietic Stem Cell Transplantation.

Infect Dis Clin North Am 2019 Jun;33(2):467-484

City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.1016/j.idc.2019.02.012DOI Listing

Severe Herpes Zoster Requiring Intravenous Antiviral Treatment in Allogeneic Hematopoietic-cell Transplantation Recipients on Standard Acyclovir Prophylaxis.

Biol Blood Marrow Transplant 2019 Apr 17. Epub 2019 Apr 17.

Brigham and Women's Hospital, Department of Infectious Diseases, Boston, Massachusetts; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts.

Allogeneic hematopoietic cell transplant (HCT) recipients are at increased risk for varicella zoster virus reactivation and associated complications. The incidence, timing, and risk factors for severe herpes zoster (HZ) are not well described in the era of acyclovir (ACV) prophylaxis. We performed a retrospective cohort study of all patients who underwent first allogeneic HCT from October 2006 to December 2015 at our institution. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.015DOI Listing
April 2019
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Understanding the immunology of Shingrix, a recombinant glycoprotein E adjuvanted herpes zoster vaccine.

Curr Opin Immunol 2019 Apr 16;59:42-48. Epub 2019 Apr 16.

Departments of Pedatrics and Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States. Electronic address:

Herpes zoster is common in older and immune suppressed persons due to diminished VZV-specific cellular immunity. A recombinant herpes zoster vaccine (RZV) consisting of a single VZV glycoprotein and an adjuvant system stimulates robust and persistent VZV-specific antibody and CD4+ T cell responses in these high-risk populations. VZV-specific immune responses induced by RZV, including the generation of polyfunctional T cells, are driven by the synergistic actions of the components of the vaccine adjuvant system. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09527915183017
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http://dx.doi.org/10.1016/j.coi.2019.02.009DOI Listing
April 2019
1 Read

Vaccination of Solid Organ Transplant Candidates and Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice.

Clin Transplant 2019 Apr 19:e13563. Epub 2019 Apr 19.

Transplant Infectious Diseases, University Health Network, Toronto, ON.

These updated guidelines of the AST IDCOP review vaccination of solid organ transplant candidates and recipients. General principles of vaccination as well as the use of specific vaccines in this population are discussed. Vaccination should be reviewed in the pre-transplant setting and appropriate vaccines updated. Read More

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http://dx.doi.org/10.1111/ctr.13563DOI Listing

Tofacitinib for the treatment of rheumatoid arthritis: an update.

Authors:
Kunihiro Yamaoka

Expert Rev Clin Immunol 2019 Apr 18. Epub 2019 Apr 18.

a Department of Rheumatology and Infectious Diseases , Kitasato University School of Medicine , 1-15-1 Kitasato, Minami-ku, Sagamihara , Kanagawa , 252-0374 Japan.

Introduction: Tofacitinib selectively inhibits the Janus kinases, intracellular tyrosine kinases that are activated by cytokines involved in the pathophysiology of rheumatoid arthritis. Areas covered: Clinical trials of tofacitinib have revealed an anti-rheumatic effect of monotherapy and combination therapy with methotrexate (MTX). Post-hoc analysis of those clinical trials and real-world experiences will be reviewed to explore tofacitinib's efficacy and safety. Read More

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https://www.tandfonline.com/doi/full/10.1080/1744666X.2019.1
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http://dx.doi.org/10.1080/1744666X.2019.1607298DOI Listing
April 2019
2 Reads

Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: Α prospective single- center study.

Transpl Infect Dis 2019 Apr 16:e13095. Epub 2019 Apr 16.

Pediatric Clinic, "P & A Kyriakou" Children's Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece.

Background: Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome.

Methods: In a prospective study from September 2011 to September 2015 blood, urine and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1111/tid.13095DOI Listing
April 2019
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Clinical Efficacy of Pretransplant Vaccination for Preventing Herpes Zoster After Living Donor Liver Transplantation in Recipients Age 50 Years and Older.

Ann Transplant 2019 Apr 17;24:208-213. Epub 2019 Apr 17.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

BACKGROUND There have been no reports concerning the efficacy of pretransplant herpes zoster (HZ) vaccination following living donor liver transplantation (LDLT). MATERIAL AND METHODS From January 2013 to May 2016, 24 patients age 50 years and older received vaccination of HZ prior to transplantation and underwent LDLT at a single institution. We compared this to the 1-year HZ incidence of unvaccinated recipients (N=180) who underwent LDLT in the same time period. Read More

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http://dx.doi.org/10.12659/AOT.914213DOI Listing

[Cutaneous Herpesvirus Infection].

Authors:
Daisuke Watanabe

Brain Nerve 2019 Apr;71(4):302-308

Dermatology, Aichi Medical University.

Among human herpes viruses, those known to cause neurological symptoms are the herpes simplex virus (HSV) types 1 and 2 and the varicella-zoster virus (VZV), which remain latent in the dorsal root ganglion. HSV causes herpes labialis, genital herpes, etc. VZV causes varicella during the primary infection, and shingles when reactivated. Read More

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https://webview.isho.jp/journal/detail/abs/10.11477/mf.14162
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http://dx.doi.org/10.11477/mf.1416201266DOI Listing
April 2019
2 Reads

Segmental zoster abdominal paresis mimicking an abdominal hernia: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(15):e15037

Department of Hepatobiliary and Abdominal Hernias Surgery, Weihai Central Hospital, Weihai, Shandong Province, People's Republic of China.

Rationale: Herpes zoster infection typically involves the posterior root ganglia and most of the symptoms are sensory. Motor involvement can occur in the same distribution but is relatively uncommon. Segmental zoster paresis is a rare motor complication of Herpes zoster, mimicking an abdominal hernia, but it needs no surgery different from the real abdominal wall hernia. Read More

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http://dx.doi.org/10.1097/MD.0000000000015037DOI Listing

Predictors of Perinatal HIV Transmission Among Women Without Prior Antiretroviral Therapy in a Resource-Limited Setting: The Breastfeeding, Antiretrovirals and Nutrition Study.

Pediatr Infect Dis J 2019 May;38(5):508-512

From the Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: To investigate potential risk factors for perinatal (intrauterine and intrapartum) mother-to-child transmission (MTCT) of HIV in women unexposed to antiretroviral therapy (ART) during pregnancy.

Methods: We compared factors according to perinatal MTCT outcome among 2275 ART-naive (until the onset of labor) HIV-infected women in the Breastfeeding, Antiretrovirals and Nutrition study (2004-2010) in Lilongwe, Malawi. Factors included HIV viral load during pregnancy, food security, demographic characteristics, hematologic and blood chemistry measures, medical history and physical factors. Read More

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http://dx.doi.org/10.1097/INF.0000000000002220DOI Listing
May 2019
1 Read

A systematic review and meta-analysis of infection risk with small molecule JAK inhibitors in rheumatoid arthritis.

Rheumatology (Oxford) 2019 Apr 14. Epub 2019 Apr 14.

Centre for Rheumatic Disease, Kings College London.

Objectives: To evaluate the risk of serious infection (SI) and herpes zoster (HZ) in rheumatoid arthritis patients receiving JAK inhibitors.

Methods: We conducted a systematic literature review and meta-analysis of phase II and III randomized controlled trials of tofacitinib (5 mg bid), baricitinib (4 mg od) and upadacitinib (15 mg od). Patient-exposure years were calculated. Read More

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http://dx.doi.org/10.1093/rheumatology/kez087DOI Listing
April 2019
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The comparative efficacy and safety of herpes zoster vaccines: A network meta-analysis.

Vaccine 2019 Apr 11. Epub 2019 Apr 11.

ICON plc, De Molen 84, Houten 3995 AX, the Netherlands.

Background: We estimated the relative efficacy and safety of vaccines for prevention of herpes zoster (HZ) using network meta-analysis (NMA) based on evidence from randomized controlled trials.

Methods: A systematic literature review evaluated two different HZ vaccines: adjuvanted recombinant zoster vaccine (RZV) and zoster vaccine live (ZVL), with different formulations assessed. Detailed feasibility assessment indicated that a NMA was feasible for efficacy (incidence of HZ and postherpetic neuralgia [PHN]) and safety (serious adverse events [SAE] and reactogenicity [injection-site reactions, systemic reaction]) outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193045
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http://dx.doi.org/10.1016/j.vaccine.2019.04.014DOI Listing
April 2019
2 Reads

Acute truncal ataxia in a healthy adult with varicella zoster virus cerebellitis: A case report and literature review.

J Neurol Sci 2019 May 2;400:186-187. Epub 2019 Apr 2.

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Acute cerebellitis is a well recognized complication of varicella zoster virus (VZV) infection in children. It has been described in adults in the setting of virus reactivation with a preceding herpes zoster rash, but it is exceedingly rare in adults who are not elderly or immunocompromised, particularly in the absence of a rash. To our knowledge, there has been only one reported case of acute cerebellitis in an immunocompetent adult less than age 65 with virological confirmation of acute VZV infection. Read More

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http://dx.doi.org/10.1016/j.jns.2019.04.001DOI Listing
May 2019
1 Read

Annular elastolytic giant cell granuloma following Herpes Zoster infection.

J Eur Acad Dermatol Venereol 2019 Apr 13. Epub 2019 Apr 13.

Institute of Dermatology, Catholic University - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

A 66-year-old psoriatic patient was examined for the occurrence of annular lesions with a dermatomeric distribution on the trunk since four weeks. The patient claimed that the lesions appeared at the site of a previous Herpes Zoster virus (HZV) infection, which had been treated with intravenous acyclovir three months earlier. At the time of the annular eruption, the patient was under treatment with apremilast (30 mg twice daily) for moderate-to-severe psoriasis, and systemic mycophenolate mofetil (1,250 gr daily), methylprednisolone (4 mg daily) and tacrolimus (1 mg daily) due to liver transplantation four years earlier for a cryptogenic liver cirrhosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.15627
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http://dx.doi.org/10.1111/jdv.15627DOI Listing
April 2019
7 Reads

Measurement of melatonin, indole-dioxygenase, IL-6, IL-18, ferritin, CRP, and total homocysteine levels during herpes zoster.

J Med Virol 2019 Apr 12. Epub 2019 Apr 12.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The risk of herpes zoster (HZ) increases with age and declining immune function. Increased oxidative stress and inflammatory conditions may cause a negative impact on the immune responses. The present study aimed to assess the levels of oxidative/inflammatory stress biomarkers in HZ patients compared with the controls. Read More

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http://dx.doi.org/10.1002/jmv.25484DOI Listing
April 2019
2.347 Impact Factor

Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe.

Pediatr Blood Cancer 2019 Apr 12:e27752. Epub 2019 Apr 12.

Department of Pediatric Hematology and Oncology, Justus Liebig University Giessen, Giessen, Germany.

Background: Epstein-Barr virus (EBV) is linked to a variety of malignancies; most endemic Burkitt lymphoma (BL) harbor EBV, whereas only a subset of the cases of sporadic BL is EBV positive.

Procedure: We retrospectively determined the herpesvirus seroprevalence at the time of diagnosis in pediatric non-Hodgkin lymphoma (NHL) patients enrolled in NHL-BFM (Berlin-Frankfurt-Muenster) studies. We accessed the seroepidemiological data from 1147 patients that became available during 1990-2007. Read More

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http://dx.doi.org/10.1002/pbc.27752DOI Listing
April 2019
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An ODE-based mixed modelling approach for B- and T-cell dynamics induced by Varicella-Zoster Virus vaccines in adults shows higher T-cell proliferation with Shingrix than with Varilrix.

Vaccine 2019 May 8;37(19):2537-2553. Epub 2019 Apr 8.

Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium; Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, Antwerp, Belgium; Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium.

Clinical trials covering the immunogenicity of a vaccine aim to study the longitudinal dynamics of certain immune cells after vaccination. The corresponding immunogenicity datasets are mainly analyzed by the use of statistical (mixed effects) models. This paper proposes the use of mathematical ordinary differential equation (ODE) models, combined with a mixed effects approach. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.075DOI Listing
May 2019
1 Read

Analysis of Vascular Event Risk After Herpes Zoster From 2007 to 2014 US Insurance Claims Data.

Mayo Clin Proc 2019 Apr 5. Epub 2019 Apr 5.

Department of Family Medicine and Community Health, University of Minnesota, Minneapolis.

Objective: To estimate the risk of transient ischemic attack (TIA), stroke, and myocardial infarction in periods covering 4 weeks before to 52 weeks after herpes zoster (HZ) diagnosis in US adults.

Patients And Methods: This retrospective study (GSK study identifier: HO-15-15771) with matched cohorts used the Truven Health MarketScan Commercial and Medicare claims data set linked with obesity and smoking status information. Patients 18 years and older at the date of HZ diagnosis and 1-year pre- and post-HZ diagnosis continuous insurance enrollment (from January 1, 2007, through December 31, 2014) were propensity score matched to controls in terms of demographic characteristics, risk factors for vascular events, other comorbid disorders, general health, obesity, and smoking status. Read More

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http://dx.doi.org/10.1016/j.mayocp.2018.12.025DOI Listing
April 2019
2 Reads

Comparison of Janus kinase inhibitors in the treatment of rheumatoid arthritis: a systemic literature review.

Immunotherapy 2019 Apr 8. Epub 2019 Apr 8.

University of Western Ontario, Schulich School of Medicine & Dentistry, Department of Medicine, London, ON, Canada.

Several Janus kinase (JAK) inhibitors, oral targeted disease-modifying drugs, will be approved for the treatment of rheumatoid arthritis (RA) and other diseases. This review compares and contrasts the efficacy of JAK inhibitors (tofacitinib, baricitinib, upadacitinib, filgotinib, peficitinib and decernotinib) in RA including: early RA methotrexate-naive patients, post methotrexate failure and post biologics. Trials in monotherapy, combination with disease modifying drugs such as methotrexate, and comparing with adalimumab in biologic-naive patients were studied. Read More

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http://dx.doi.org/10.2217/imt-2018-0178DOI Listing

Post-total knee arthroplasty herpes zoster activation.

BMJ Case Rep 2019 Apr 5;12(4). Epub 2019 Apr 5.

Department of Trauma and Emergency (Anesthesia), All India Institute of Medical Sciences Bhubaneswar, Orissa, India.

Herpes zoster is a clinical manifestation of reactivation of varicella-zoster virus (VZV) that lies dormant in the dorsal root ganglia after a past primary infection. It can be associated with severe pain, a crop of vesicles in typical dermatomal distribution but the neuralgic pain persists long, making the patient uncomfortable and often disturbing patient's sleep. There are cases reported after trauma or post surgeries that are mainly related to organ transplant or malignancy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228639DOI Listing
April 2019
2 Reads

High rate of recurrence of herpes zoster-related ocular disease after phacoemulsification cataract surgery.

J Cataract Refract Surg 2019 Apr 4. Epub 2019 Apr 4.

Greenlane Clinical Centre, Auckland District Health Board, New Zealand. Electronic address:

Purpose: To examine the outcomes of phacoemulsification cataract surgery in eyes with herpes zoster-related keratitis and/or uveitis and evaluate the risks for recurrent disease.

Setting: Public ophthalmology service, Auckland, New Zealand.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1016/j.jcrs.2019.01.003DOI Listing
April 2019
2 Reads

Safety and efficacy of tofacitinib for up to 9.5 years in the treatment of rheumatoid arthritis: final results of a global, open-label, long-term extension study.

Arthritis Res Ther 2019 Apr 5;21(1):89. Epub 2019 Apr 5.

Metroplex Clinical Research Center and University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Final data are presented for the ORAL Sequel long-term extension (LTE) study evaluating the safety and efficacy of tofacitinib 5 mg and 10 mg twice daily (BID) for up to 9.5 years in patients with rheumatoid arthritis (RA).

Methods: Eligible patients had previously completed a phase 1, 2, or 3 qualifying index study of tofacitinib and received open-label tofacitinib 5 mg or 10 mg BID. Read More

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http://dx.doi.org/10.1186/s13075-019-1866-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451219PMC

Interferon Alpha 2a and 2b in Ophthalmology: A Review.

J Interferon Cytokine Res 2019 Apr 5. Epub 2019 Apr 5.

1 Department and Clinic of Ophthalmology, University of Wrocław Medical College, Wrocław, Poland.

Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc.), hematological disorders (leukemia, multiple myeloma, T cell lymphoma, and essential thrombocythemia), and solid tumors (clear cell carcinoma in the metastatic stage, melanoma, hepatocellular carcinoma, and cervical neoplasia). Studies have proven the effectiveness of IFN-α in the treatment of ophthalmic disorders involving the anterior segment of the eye (conjunctival papilloma, squamous neoplasia, conjunctival mucosa-associated lymphoid tissue, Mooren's ulcer, and vernal keratoconjunctivitis) and the posterior segment of the eye (serpiginous choroidopathy, posterior uveitis, pseudophakic and diabetic cystoid macular edema, and proliferative diabetic retinopathy). Read More

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https://www.liebertpub.com/doi/10.1089/jir.2018.0125
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http://dx.doi.org/10.1089/jir.2018.0125DOI Listing
April 2019
4 Reads

Pericarditis caused by herpes zoster.

J Cardiol Cases 2019 Mar 23;19(3):77-80. Epub 2018 Dec 23.

Department of Cardiovascular Medicine, Tokyo Teishin Hospital, Tokyo, Japan.

A 53-year-old immunocompetent male visited our hospital complaining of chest pain which persisted for 6 h. After detailed examination, the patient was diagnosed with viral pericarditis and treated with aspirin. On day 3 after admission, rash with blisters appeared on the right side of chest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18785409183010
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http://dx.doi.org/10.1016/j.jccase.2018.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429528PMC
March 2019
5 Reads

Pulsed immune reconstitution therapy in multiple sclerosis.

Ther Adv Neurol Disord 2019 28;12:1756286419836913. Epub 2019 Mar 28.

Department of Neurology, Danish Multiple Sclerosis Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Whereas drugs used for maintenance/escalation therapy do not maintain their beneficial effect after cessation of therapy, some new highly effective therapies can show prolonged treatment effects after a short treatment course. Such therapies have been named pulsed immune reconstitution therapies or pulsed immunosuppressive therapies, and typical representatives are alemtuzumab and cladribine. Autologous haematopoietic stem cell transplantation could be considered as the strongest immune reconstitution therapy. Read More

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http://dx.doi.org/10.1177/1756286419836913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440030PMC
March 2019
5 Reads

Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.

BMC Ophthalmol 2019 Apr 3;19(1):87. Epub 2019 Apr 3.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist, Kaohsiung, 833, Taiwan.

Background: To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan.

Methods: A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Read More

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http://dx.doi.org/10.1186/s12886-019-1093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448235PMC
April 2019
2 Reads

Post-shingles granulomatous dermatosis related to anti-programmed cell death 1.

Immunotherapy 2019 May;11(7):591-598

Department of Haematology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

The most recent progress in the oncology field has led to a paradigm shift in the management of cancer with the tsunami of immune checkpoint inhibitors that are associated with a particular pattern of immunological adverse events. This is a case of a 54-year-old woman that demonstrated a granulomatous reaction in the same dermatomal distribution of a previously treated shingles infection during treatment with an anti-programmed death 1 agent (pembrolizumab) for a newly diagnosed stage IV Hodgkin lymphoma. The purpose of this case is to increase the awareness of oncologists dealing with a new pattern of side effects taking into account the patient's background and recent exposures to latent viruses such as herpes zoster to prevent unnecessary diagnostic and therapeutic measures. Read More

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https://www.futuremedicine.com/doi/10.2217/imt-2018-0169
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http://dx.doi.org/10.2217/imt-2018-0169DOI Listing
May 2019
1 Read
2.440 Impact Factor

[Efficacy of assisted treatment of thumb-tack acupuncture with surrounding needling method for herpes zoster of stagnated heat in liver meridian].

Zhongguo Zhen Jiu 2019 Feb;39(2):149-53

Department of Neurology, Lianyungang Affiliated Hospital of Nanjing University of TCM.

Objective: To compare the efficacy difference between thumb-tack acupuncture with surrounding needling method plus medication and medication alone for herpes zoster (HZ) of stagnated heat in liver meridian type.

Methods: According to random number table method, 60 patients with HZ of stagnated heat in liver meridian type were randomly divided into an observation group and a control group, 30 cases in each one. All the patients were treated with oral valaciclovir hydrochloride dispersible tablets (0. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2019.02.010DOI Listing
February 2019
2 Reads

Fifty Years in Search of Selective Antiviral Drugs.

Authors:
Erik De Clercq

J Med Chem 2019 Apr 12. Epub 2019 Apr 12.

Department of Microbiology and Immunology, Rega Institute for Medical Research , KU Leuven , Herestraat 49 , 3000 Leuven , Belgium.

Fifty years of research (1968-2018) toward the identification of selective antiviral drugs have been primarily focused on antiviral compounds active against DNA viruses (HSV, VZV, CMV, HBV) and retroviruses (HIV). For the treatment of HSV infections the aminoacyl esters of acyclovir were designed, and valacyclovir became the successor of acyclovir in the treatment of HSV and VZV infections. BVDU (brivudin) still stands out as the most potent among the marketed compounds for the treatment of VZV infections (i. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00175DOI Listing
April 2019
2 Reads

Case of herpes zoster complicated by diaphragmatic paralysis.

J Dermatol 2019 Apr 2. Epub 2019 Apr 2.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14878DOI Listing
April 2019
5 Reads

Multi-organ involvement secondary to varicella zoster virus, herpes simplex virus and cytomegalovirus in an immunocompromised patient.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Division of Pulmonaryand Critical Care Medicine, University of South Florida, Tampa, Florida, USA.

The use of immunosuppressing agents can act as a catalyst for viral reactivation, promoting systemic infection with organ involvement. Current literature remains sparse on this topic but does provide individual case reports involving single viruses. We present the case of an immunocompromised patient with skin lesions, pancreatitis, colitis and hepatitis. Read More

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http://dx.doi.org/10.1136/bcr-2018-228150DOI Listing
March 2019
3 Reads

Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil.

Braz J Infect Dis 2019 Mar 29. Epub 2019 Mar 29.

Section of Infectious Diseases, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre, Brazil. Electronic address:

Background: There is little information on herpes zoster from hospital registries in South America. The aim of this study was to describe the epidemiological and clinical aspects of herpes zoster (HZ) in hospitalized patients.'

Methods: We searched for hospital-based records during the period from March 2000 to January 2017 in a 700-bed tertiary-care hospital located in southern Brazil. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.03.001DOI Listing
March 2019
5 Reads

Safety profile of the adjuvanted recombinant zoster vaccine: Pooled analysis of two large randomised phase 3 trials.

Vaccine 2019 Apr 29;37(18):2482-2493. Epub 2019 Mar 29.

GSK, Wavre, Belgium. Electronic address:

Background: The ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229) phase 3 clinical trials showed that the adjuvanted recombinant zoster vaccine (RZV) was ≥90% efficacious in preventing herpes zoster in adults. Here we present a comprehensive overview of the safety data from these studies.

Methods: Adults aged ≥50 (ZOE-50) and ≥70 (ZOE-70) years were randomly vaccinated with RZV or placebo. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.03.043DOI Listing
April 2019
3 Reads

Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review.

Complement Ther Med 2019 Apr 22;43:81-84. Epub 2019 Jan 22.

Ortenau Klinikum Offenburg und Gengenbach, Ebertplatz 12, 77654, Offenburg, Germany. Electronic address:

Objectives: To assess the value of bee products with respect to antiviral efficacy against herpes viruses.

Design: A systematic review was done using the JUSTfind System of the Justus-Liebig-University Gießen and Scopus.

Results: Three trials on honey and 6 trials on propolis were conducted. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.01.014DOI Listing
April 2019
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Cost-Effectiveness of the Adjuvant Recombinant Zoster Vaccine in Japanese Adults Aged 65 Years and Older.

Dermatol Ther (Heidelb) 2019 Mar 30. Epub 2019 Mar 30.

Department of Dermatology, Aichi Medical University, Aichi, Japan.

Introduction: The incidence of herpes zoster (HZ) rises steeply after the age of 50 years and the number of HZ cases and complications such as postherpetic neuralgia (PHN) is predicted to increase because of the ageing population. The objective of this study was to estimate the cost-effectiveness of recombinant zoster vaccine (RZV) compared with no vaccine for the Japanese population aged ≥ 65 years.

Methods: A multi-cohort static Markov model with a cycle length of 1 year was used to follow a hypothetical cohort of 1 million people aged ≥ 65 years over their remaining lifetime. Read More

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http://dx.doi.org/10.1007/s13555-019-0291-4DOI Listing
March 2019
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Delayed Diagnosis of Herpes Zoster Infection due toLong-Term Pregabalin Treatment for Lumbar Spinal Canal Stenosis: A Case Report.

J Orthop Case Rep 2018 Nov-Dec;8(6):85-87

Department of Internal Medicine, Navitas Clinic Shinjuku, Tokyo, Japan.

Introduction: Lumbar spinal stenosis is a common disease among elderly adults, and pregabalin is increasingly used for pain relief in this disease. However, little is known about whether pregabalin may cause any undesirable outcomes when used conjointly with other medications in elderly people. We report a case of herpes zoster infection, the initial symptom of which was obscured due to the use of a combination of pregabalin, tramadol, and acetaminophen for lumbar spinal canal stenosis. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424327PMC
March 2019
2 Reads

Herpes zoster vaccination efficacy in the long-term care facility population: a qualitative systematic review.

Curr Med Res Opin 2019 Mar 27:1-12. Epub 2019 Mar 27.

e Baycrest Health Sciences , Toronto , Canada.

Background: The varicella zoster virus (VZV) can reactivate later in life as herpes zoster infection (HZI), a severe disease resulting in painful complications such as post-herpetic neuralgia (PHN). The herpes zoster (HZ) vaccine has been indicated for use among adults 50 years and older for prevention of HZI. Currently, no clinical practice guideline or funding exists specifically for HZ immunization in long-term care facilities (LTCF) for adults age >60 years. Read More

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https://www.tandfonline.com/doi/full/10.1080/03007995.2019.1
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http://dx.doi.org/10.1080/03007995.2019.1600482DOI Listing
March 2019
7 Reads

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia.

Front Neurosci 2019 8;13:170. Epub 2019 Mar 8.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.

Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, manifesting as a persistent, spontaneous, knife-like pain or paroxysmal burning that seriously affects a patient's quality of life. An effective treatment of PHN is lacking. This retrospective study examined the efficacy and safety of stellate ganglion (SG) pulsed radiofrequency (PRF) on facial and upper limb PHN. Read More

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http://dx.doi.org/10.3389/fnins.2019.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418026PMC
March 2019
2 Reads

An Association Between Herpes Zoster Vaccination and Stroke Reduction Among Elderly Individuals.

Mil Med 2019 03;184(Suppl 1):126-132

Defense Health Agency-Immunization Healthcare Branch Regional Office, Building 1-2532 Armistead St, Fort Bragg, NC.

Herpes zoster (HZ, shingles) affects individuals (60+ years) by reactivation of varicella virus from primary infection. Approximately one-third of the general population will develop HZ and are at increased risk of stroke. Our objective was describing possible associations between self-reported HZ vaccination and stroke with the Centers for Disease Control and Prevention's Behavioral Risk Factors Surveillance System, a cross-sectional nationwide telephone survey. Read More

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https://academic.oup.com/milmed/article/184/Supplement_1/126
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http://dx.doi.org/10.1093/milmed/usy343DOI Listing
March 2019
10 Reads

Risk of herpes zoster with IL-17 inhibitor therapy for psoriasis and other inflammatory conditions.

J Dermatolog Treat 2019 Mar 22:1-7. Epub 2019 Mar 22.

d Dermatology Research and Education Foundation , Irvine , CA , USA.

Background: Psoriasis is a chronic inflammatory skin disease that has been associated with a significantly higher risk of herpes zoster (HZ). Several newer biologics such as secukinumab, ixekizumab, and brodalumab inhibit IL-17 and have been highly effective for treatment of psoriasis. However, adverse events related to the immunosuppressive properties of these biologics have been observed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1597246DOI Listing
March 2019
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Efficacy and safety of tofacitinib for the treatment of rheumatoid arthritis in patients from the Asia-Pacific region: Post-hoc analyses of pooled clinical study data.

Int J Rheum Dis 2019 Mar 22. Epub 2019 Mar 22.

University of Occupational and Environmental Health Japan, Kitakyushu, Japan.

Aim: We report tofacitinib efficacy and safety in Asia-Pacific patients who participated in the rheumatoid arthritis (RA) clinical development program.

Method: This post-hoc analysis included pooled data from patients with RA in the Asia-Pacific region treated with tofacitinib with/without conventional synthetic disease-modifying antirheumatic drugs in Phase (P)1, 2, 3, and long-term extension (LTE) studies (one LTE ongoing; January 2016 data-cut). Efficacy was assessed over 24 months in patients who received tofacitinib 5 (N = 397) or 10 (N = 382) mg twice daily or placebo (N = 243) in three P2 and five P3 studies. Read More

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http://dx.doi.org/10.1111/1756-185X.13516DOI Listing
March 2019
3 Reads

Simultaneous parotitis and ipsilateral herpes zoster ophthalmicus: coincidence?

BMJ Case Rep 2019 Mar 20;12(3). Epub 2019 Mar 20.

Family Medicine, Ascension Providence Hospital, Novi, Michigan, USA.

A 43-year-old previously healthy man presented to the primary care clinic with concurrent ipsilateral viral parotitis and herpes zoster ophthalmicus. The patient experienced painful swelling below the right ear as well as painful vesicles on the right forehead, eyelid and cheek in the V1 dermatomal region. There were no lesions in the oral cavity or nose. Read More

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http://dx.doi.org/10.1136/bcr-2018-228897DOI Listing
March 2019
1 Read

Efficacy of amenamevir for the treatment of herpes zoster in an immunocompromised patient: Report of a case.

J Dermatol 2019 Mar 21. Epub 2019 Mar 21.

Department of Dermatology, Aichi Medical University, Nagakute, Japan.

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http://dx.doi.org/10.1111/1346-8138.14854DOI Listing
March 2019
5 Reads

Missed opportunities for earlier diagnosis of HIV in British Columbia, Canada: A retrospective cohort study.

PLoS One 2019 21;14(3):e0214012. Epub 2019 Mar 21.

British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.

Background: Late HIV diagnosis is associated with increased AIDS-related morbidity and mortality as well as an increased risk of HIV transmission. In this study, we quantified and characterized missed opportunities for earlier HIV diagnosis in British Columbia (BC), Canada.

Design: Retrospective cohort. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214012PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428302PMC
March 2019
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Human herpesvirus infections and dementia or mild cognitive impairment: a systematic review and meta-analysis.

Sci Rep 2019 Mar 18;9(1):4743. Epub 2019 Mar 18.

Faculty of Epidemiology & Population Health, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, United Kingdom.

Interest is growing in the role of infectious agents in the pathogenesis of dementia, but current evidence is limited. We conducted a systematic review and meta-analysis to investigate the effect of any of eight human herpesviruses on development of dementia or mild cognitive impairment (MCI). We searched the Cochrane Library, Embase, Global Health, Medline, PsycINFO, Scopus, Web of Science, clinical trials registers and grey literature sources from inception to December 2017 for observational studies with cohort, case control or self-controlled designs, or randomised controlled trials of interventions against herpesviruses. Read More

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http://dx.doi.org/10.1038/s41598-019-41218-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426940PMC
March 2019
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Case of herpes zoster with herpetic folliculitis complicated with meningitis: Immunohistochemistry.

J Dermatol 2019 Mar 19. Epub 2019 Mar 19.

Department of Dermatology, Aichi Medical University, Nagakute, Japan.

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http://dx.doi.org/10.1111/1346-8138.14851DOI Listing
March 2019
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Herpes zoster onset 9 years after first varicella zoster vaccination in a 11 year old child - a case report.

Curr Pediatr Rev 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, University General Hospital of Patras. Greece.

Background: Herpes zoster (HZ) tends to affect the elderly population and immunocompromised younger patients. However, HZ cases in healthy children have also been reported.

Objective: This paper is a reminder to physicians, that Herpes Zoster can still present in children, even in the era after the development of the varicella vaccine and its introduction in the national immunization programs globally. Read More

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http://dx.doi.org/10.2174/1573396315666190318163927DOI Listing
March 2019
1 Read