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    Orbital apex syndrome as a complication of herpes zoster ophthalmicus.
    BMJ Case Rep 2017 Feb 24;2017. Epub 2017 Feb 24.
    Centre for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, India.
    Orbital apex syndrome is a rare neuro-ophthalmic manifestation of herpes zoster virus infection. We report one such case with favourable outcome in an immunocompetent patient. A 60-year-old woman presented with rash in the dermatome of the left ophthalmic nerve (V1), followed by sudden loss of vision with complete left-sided external and internal ophthalmoplegia. Read More

    Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients.
    Medicine (Baltimore) 2017 Feb;96(8):e5997
    aDepartment of Pain, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province bCentral Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated Nanjing University of Chinese Medicine, Nanjing, China.
    Postherpetic neuralgia (PHN) is commonly defined as pain persisting for at least 3 months after acute herpes zoster (AHZ) rash presentation. About one-tenth of all acute herpes zoster patients develop PHN. Circulating microRNAs (miRNAs) are promising biomarkers for infectious diseases; however, there has been no relationship established between circulating miRNAs and PHN to date; the aim of the present investigation was to elucidate this relationship. Read More

    Incidence of varicella zoster virus infections of the central nervous system in the elderly: a large tertiary hospital-based series (2007-2014).
    J Neurovirol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Neurology, Hospital Universitario Donostia, 20014, San Sebastian, Spain.
    The aim of the study was to describe the clinical and epidemiological characteristics of the central nervous system (CNS) infection by varicella zoster virus (VZV) in patients older than 65 years in a tertiary community hospital. We retrospectively analysed the results of cerebrospinal fluid (CSF) testing in patients older than 65 years between 2007 and 2014 with clinically suspected VZV infection with CNS involvement. Patients whose CSF samples were positive for VZV DNA were included, as were those with negative results who simultaneously presented herpes zoster and CSF or magnetic resonance imaging findings suggestive of CNS infection, and in whom other possible aetiologies had been ruled out. Read More

    The role of age-sex interaction in the development of post-herpetic neuralgia.
    Hum Vaccin Immunother 2017 Feb;13(2):376-378
    a Department of Health Sciences , University of Genoa , Genoa , Italy.
    Post-herpetic neuralgia is the most frequent complication of herpes zoster and affects up to 30% of patients. Increased age is a well-recognized risk factor, while the role of gender is highly uncertain. Little research has been performed into a possible combined effect of age and sex in post-herpetic neuralgia. Read More

    Herpes zoster correlates with increased risk of Parkinson's disease in older people: A population-based cohort study in Taiwan.
    Medicine (Baltimore) 2017 Feb;96(7):e6075
    aCollege of Medicine bDepartment of Family Medicine cCollege of Chinese Medicine dManagement Office for Health Data, China Medical University Hospital eDepartment of Healthcare Administration, College of Health Science, Asia University, Taichung fCollege of Medicine, Tzu Chi University, Hualien gGraduate Institute of Integrated Medicine, China Medical University hDepartment of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan.
    Little is known on the relationship between herpes zoster and Parkinson's disease in older people. This study aimed to explore whether herpes zoster could be associated with Parkinson's disease in older people in Taiwan.We conducted a retrospective cohort study using the claim data of the Taiwan National Health Insurance Program. Read More

    Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children.
    Arch Virol 2017 Feb 15. Epub 2017 Feb 15.
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
    This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. Read More

    [Hypogeusia and High Signals in the Nuclei of the Solitary Tract on MRI due to Varicella-Zoster Virus Infection: A Case Report].
    Brain Nerve 2017 Feb;69(2):173-177
    Department of Neurology, Brain Attack Center Ota Memorial Hospital.
    A 63-year-old man noticed hypogeusia after presenting hiccups for several days. He was serologically diagnosed with varicella-zoster virus (VZV) infection, but had no skin lesions typical of herpes (zoster sine herpete). Hypogeusia was confirmed by electrogustometry and the filter-paper disk method, which showed damage in the areas innervated by the cord of tympanum, glossopharyngeal nerve, and greater petrosal nerve. Read More

    Acute HIV-1 infection presenting with fulminant encephalopathy.
    Int J STD AIDS 2017 Jan 1:956462417693734. Epub 2017 Jan 1.
    1 Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
    Human immunodeficiency virus (HIV)-1 directly affects the nervous system, causes distinct neurological symptoms, and indirectly results in opportunistic infections, which include herpes virus simplex (HSV)-1, HSV-2, varicella zoster virus, and cytomegalovirus encephalitis caused by immunodeficiency. Early HIV-1 invasion of the central nervous system is also possible, and acute encephalopathy is a potentially lethal complication. We encountered a case of fulminant encephalopathy as a primary presentation of acute HIV-1 infection, in which highly active antiretroviral treatment resulted in a full clinical recovery. Read More

    [The alpha-herpesviridae in dermatology : Varicella zoster virus. German version].
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien.
    The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal. Furthermore, certain associations between the occurrence of HZ and subsequent internal pathologies, as well as risk factors for HZ and new developments in vaccination against HZ will be addressed. Read More

    The alpha-herpesviridae in dermatology : Varicella zoster virus.
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.
    The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal. Furthermore, certain associations between the occurrence of HZ and subsequent internal pathologies, as well as risk factors for HZ and new developments in vaccination against HZ will be addressed. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Herpes Zoster Lesions on Reconstructed Breast Skin: Rare Objective Proof of Reinervation.
    Arch Plast Surg 2017 Jan 20;44(1):72-75. Epub 2017 Jan 20.
    Department of Hand-, Breast-, and Reconstructive Microsurgery, Marienhospital Stuttgart, Stuttgart, Germany.
    Blazed up Herpes zoster lesions have been described in very few patients after free and pedicled flap transfer for reconstructive purpose. Although sensory recovery after flap reconstructions has been studied extensively most studies addressed subjective perceptions of sensation. Objective investigations of spontaneous reinervation of free and pedicled flaps are rare. Read More

    Diagnosis and management of acute encephalitis.
    Handb Clin Neurol 2017 ;140:337-347
    Overlook Medical Center, Summit, NJ; Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:
    Encephalitis is typically viral (approximately half of diagnosed cases) or autoimmune (about a quarter) with the remainder remaining undiagnosable at this time. All require general supportive care but only a minority requires intensive care admission - in these intubation, to protect the airway or to treat status epilepticus with anesthetic drugs, may be needed. In some dysautonomia with wide blood pressure fluctuations is the principal concern. Read More

    Herpes zoster and the risk of ischemic and hemorrhagic stroke: A systematic review and meta-analysis.
    PLoS One 2017 8;12(2):e0171182. Epub 2017 Feb 8.
    Department of Neurology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, China.
    Background: Herpes zoster infection and stroke are highly prevalent in the general population; however, reports have presented inconsistent findings regarding the relationship between herpes zoster infection and stroke. In this meta-analysis, we aimed to clarify this association.

    Material And Methods: The PubMed and Embase databases were searched for studies published from their inception to January 2016. Read More

    Safety of Second-Dose Single-Antigen Varicella Vaccine.
    Pediatrics 2017 Feb 7. Epub 2017 Feb 7.
    Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases.
    Background And Objective: In 2006, routine 2-dose varicella vaccination for children was recommended to improve control of varicella. We assessed the safety of second-dose varicella vaccination.

    Methods: We identified second-dose single-antigen varicella vaccine reports in the Vaccine Adverse Event Reporting System during 2006 to 2014 among children aged 4 to 18 years. Read More

    Safety of live vaccinations on immunosuppressive therapy in patients with immune-mediated inflammatory diseases, solid organ transplantation or after bone-marrow transplantation - A systematic review of randomized trials, observational studies and case reports.
    Vaccine 2017 Mar 3;35(9):1216-1226. Epub 2017 Feb 3.
    Department of Public Health, Division of Infectious Diseases/Travel Clinic, Epidemiology, Biostatistics and Prevention Institute, Hirschengraben 84, 8001 Zurich, Switzerland. Electronic address:
    Background: Live vaccines are generally contraindicated on immunosuppressive therapy due to safety concerns. However, data are limited to corroborate this practice.

    Objectives: To estimate the safety of live vaccinations in patients with immune-mediated inflammatory diseases (IMID) or solid organ transplantation (SOT) on immunosuppressive treatment and in patients after bone-marrow transplantation (BMT). Read More

    Prevention of Post-herpetic Neuralgia from Dream to Reality: A Ten-step Model.
    Pain Physician 2017 Feb;20(2):E209-E220
    Departments of Anesthesiology and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Egypt.
    Herpes zoster (HZ) is a painful, blistering skin eruption in a dermatomal distribution caused by reactivation of a latent varicella zoster virus in the dorsal root ganglia (DRG). Post-herpetic neuralgia (PHN) is the most common complication of acute herpes zoster (AHZ).Severe prodrome, greater acute pain and dermatomal injury, and the density of the eruption are the risk factors and predictors for developing PHN. Read More

    Bizarre cell dysplasia of the cervix.
    J Obstet Gynaecol Res 2017 Feb;43(2):345-351
    Šikl's Department of Pathology, Medical Faculty Hospital, Charles University, Pilsen, Czech Republic.
    Aim: The aim of this study was the characterization of a new subtype of high-grade cervical squamous intraepithelial lesion (HSIL) with enlarged cells containing bizarre nuclei: so-called bizarre cell dysplasia (BCD).

    Methods: A total of 29 cervical cone biopsy samples of this type of dysplasia were studied. Multi-target polymerase chain reaction and in situ hybridization human papillomavirus (HPV) detection was performed in all cases. Read More

    Late-Onset of Acute Severe Ulcerative Colitis: Clinical Case.
    Dig Dis 2017 1;35(1-2):45-49. Epub 2017 Feb 1.
    National Medical University n.a.A.A.Bogomoletz, Kiev, Ukraine.
    Ulcerative colitis (UC) in adult age requires more careful examination because more often it turns out to be a complication related to the precancer condition. The onset of colitis in older age is predicted to follow a more aggressive clinical course and requires more frequent hospitalizations and steroids prescription in contrast to its onset in young patients. Even as this remains unclear, we present here a clinical case of late onset of acute severe UC to represent interesting clinical peculiarities and response to the therapy. Read More

    Safety of Tofacitinib in the Treatment of Rheumatoid Arthritis in Latin America Compared With the Rest of the World Population.
    J Clin Rheumatol 2017 Feb 1. Epub 2017 Feb 1.
    From the *Clínica Angloamericana, Lima, Peru; †Instituto Peruano del Hueso y la Articulación, Lima, Peru; ‡Hospital Nacional Alberto Sabogal, Bellavista, Callao, Peru; §Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina; ∥Organización Médica de Investigación, Buenos Aires, Argentina; ¶Section of Rheumatology, Department of Medicine, Hospital Dr I Pirovano, Ciudad Autónoma de Buenos Aires, Argentina; #Universidade Federal do Paraná, Curitiba, Brazil; **Centro de Investigación Clínica de Morelia, Morelia, México; ††Centro de Reumatología y Ortopedia, Barranquilla, Colombia; ‡‡Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia; §§Pfizer Inc., Lima, Peru; ∥∥Pfizer Inc., Buenos Aires, Argentina; ¶¶Pfizer Inc., Collegeville, PA, USA; ##Pfizer Inc., New York, NY, USA; and ***Pfizer Inc., Groton, CT, USA.
    Objective: Rheumatoid arthritis (RA) is a chronic, autoimmune disease characterized by joint destruction. Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. This post hoc analysis assessed the safety of tofacitinib in Latin American (LA) patients with RA versus the Rest of World (RoW) population. Read More

    Long-term safety of tofacitinib for the treatment of rheumatoid arthritis up to 8.5 years: integrated analysis of data from the global clinical trials.
    Ann Rheum Dis 2017 Jan 31. Epub 2017 Jan 31.
    University of Hamburg, Hamburg, Germany.
    Objectives: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We report an integrated safety summary of tofacitinib from two phase I, nine phase II, six phase III and two long-term extension studies in adult patients with active RA.

    Methods: Data were pooled for all tofacitinib-treated patients (data cut-off: 31 March 2015). Read More

    [Herpes zoster in elderly adults in a community hospital in Buenos Aires. June 2013-May 2014].
    Medicina (B Aires) 2017 ;77(1):24-30
    Sección Geriatría, Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
    Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus. Its main risk factor is increasing age and comorbidities. There are limited data on the characteristics of HZ in South America, especially in the elderly. Read More

    Cutaneous manifestations of systemic viral diseases in neonates: an update.
    Curr Opin Pediatr 2017 Jan 27. Epub 2017 Jan 27.
    aGeisel School of Medicine at Dartmouth, Hanover, NH bSection of Dermatology, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH cUniversity of Connecticut, Farmington, CT and Seacoast Dermatology, Portsmouth, NH, USA.
    Purpose Of Review: Dermatologic findings may be the first signs of a neonatal viral infection. This review provides an update of the diagnostic features and therapies for selected viral illnesses [herpes simplex virus (HSV), varicella zoster virus, enterovirus, and Zika virus] that present with cutaneous manifestations in the neonate.

    Recent Findings: HSV DNA polymerase chain reaction of plasma and cerebrospinal fluid, routinely used in the diagnosis of neonatal HSV, may have expanded utility in assessing prognosis and acyclovir therapeutic efficacy. Read More

    Other facial neuralgias.
    Cephalalgia 2017 Jan 1:333102417689995. Epub 2017 Jan 1.
    4 Department of Neurology, University of Würzburg, Germany.
    Premise In this article we review some lesser known cranial neuralgias that are distinct from trigeminal neuralgia, trigeminal autonomic cephalalgias, or trigeminal neuropathies. Included are occipital neuralgia, superior laryngeal neuralgia, auriculotemporal neuralgia, glossopharyngeal and nervus intermedius neuralgia, and pain from acute herpes zoster and postherpetic neuralgia of the trigeminal and intermedius nerves. Problem Facial neuralgias are rare and many physicians do not see such cases in their lifetime, so patients with a suspected diagnosis within this group should be referred to a specialized center where multidisciplinary team diagnosis may be available. Read More

    Antiviral prophylaxis for preventing herpes zoster in hematopoietic stem cell transplant recipients: A systematic review and meta-analysis.
    Antiviral Res 2017 Apr 26;140:106-115. Epub 2017 Jan 26.
    Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:
    The optimal duration of prophylaxis for the varicella-zoster virus following hematopoietic stem cell transplantation (HSCT) remains unclear. The purpose of this study was to systematically review the available literature to determine the optimal duration of antiviral prophylaxis for preventing herpes zoster (HZ) in allogeneic and autologous HSCT recipients. The MEDLINE and EMBASE databases were searched to identify relevant studies. Read More

    Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus.
    Arthritis Rheumatol 2017 Feb;69(2):376-386
    Regenxbio, Rockville, Maryland.
    Objective: To assess the efficacy and safety of anifrolumab, a type I interferon (IFN) receptor antagonist, in a phase IIb, randomized, double-blind, placebo-controlled study of adults with moderate-to-severe systemic lupus erythematosus (SLE).

    Methods: Patients (n = 305) were randomized to receive intravenous anifrolumab (300 mg or 1,000 mg) or placebo, in addition to standard therapy, every 4 weeks for 48 weeks. Randomization was stratified by SLE Disease Activity Index 2000 score (<10 or ≥10), oral corticosteroid dosage (<10 or ≥10 mg/day), and type I IFN gene signature test status (high or low) based on a 4-gene expression assay. Read More

    [Herpes zoster and post-herpetic neuralgia in the elderly: Particularities in prevention, diagnosis, and treatment].
    Gac Med Mex 2017 Jan-Feb;153(1):92-101
    Instituto Nacional de Geriatría, Ciudad de México, México.
    Herpes zoster (HZ) results from the reactivation of the varicella zoster virus latent in the sensory ganglia when cell-mediated immunity is altered. It is a frequent condition in older adults, leading to undesirable adverse outcomes. Aging is its main risk factor and the elderly may have different clinical presentations: zoster sine herpete, and a higher incidence of post-herpetic neuralgia (15%) and ophthalmic herpes (7%). Read More

    Retinal Microvasculopathy Is Common in HIV/AIDS Patients: A Cross-Sectional Study at the Cape Coast Teaching Hospital, Ghana.
    J Ophthalmol 2016 29;2016:8614095. Epub 2016 Dec 29.
    Department of Optometry, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
    Purpose. The purpose of this study was to evaluate the ocular disorders in HIV positive patients attending the Cape Coast Teaching Hospital, Ghana. Methods. Read More

    Psoas compartment block for treatment of motor weakness and pain following herpes zoster.
    Korean J Pain 2017 Jan 30;30(1):62-65. Epub 2016 Dec 30.
    School of Dentistry, Kyungpook National University, Daegu, Korea.
    Reactivation of the latent varicella zoster virus in the sensory ganglion causes herpes zoster (HZ). Its characteristic symptom is a painful rash in the involved dermatome. HZ-induced motor weakness is rare and is usually resolved within one year of the onset, but some patients permanently experience motor dysfunction. Read More

    Effects of applying nerve blocks to prevent postherpetic neuralgia in patients with acute herpes zoster: a systematic review and meta-analysis.
    Korean J Pain 2017 Jan 30;30(1):3-17. Epub 2016 Dec 30.
    Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background: Postherpetic neuralgia (PHN) is a common and painful complication of acute herpes zoster. In some cases, it is refractory to medical treatment. Preventing its occurrence is an important issue. Read More

    Peficitinib, a JAK inhibitor, in combination with limited conventional synthetic DMARDs in the treatment of moderate-to-severe rheumatoid arthritis.
    Arthritis Rheumatol 2017 Jan 24. Epub 2017 Jan 24.
    Centro de Investigación Clínica de Morelia SC, Morelia, Mexico.
    Objective: To evaluate the efficacy and safety of orally administered once-daily peficitinib in patients with moderate-to-severe rheumatoid arthritis (RA) in combination with limited conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).

    Methods: In this double-blind, randomized, phase IIb trial, patients with RA (N=289) were treated with peficitinib 25 mg, 50 mg, 100 mg, 150 mg, or matching placebo once daily for 12 weeks. Primary endpoint was the percentage of patients achieving an American College of Rheumatology (ACR) 20% response at Week 12. Read More

    The temporal impact of aging on the burden of herpes zoster.
    BMC Geriatr 2017 Jan 23;17(1):30. Epub 2017 Jan 23.
    GSK, Wavre, Belgium.
    Background: The risk of Herpes Zoster (HZ) increases with age and various studies have also demonstrated an increasing HZ incidence globally. Simultaneously, the global trend of an aging population has placed a greater burden on the healthcare system. This study aims to estimate the potential burden of HZ over time accounting for the increasing trends of both HZ incidence and global aging. Read More

    Pseudoherpetic transient acantholytic dermatosis (Grover disease): case series and review of the literature.
    J Cutan Pathol 2017 Jan 18. Epub 2017 Jan 18.
    Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
    A total of 3 cases of pseudoherpetic transient acantholytic dermatosis (Grover disease) are presented, followed by a brief review of prior reports. All 3 patients were above the age of 60 and presented with a pruritic eruption composed of papules with or without vesicles distributed on the trunk. For all 3 patients, the clinical differential diagnosis included drug eruption but did not include Grover disease; in 1 patient, the clinical impression included herpesvirus infection. Read More

    Association between work time loss and quality of life in patients with Herpes Zoster: a pooled analysis of the MASTER studies.
    Health Qual Life Outcomes 2017 Jan 18;15(1):11. Epub 2017 Jan 18.
    Center for Observational and Real-World Evidence, Merck & Co., Inc., 2000 Galloping Hill Rd, Kenilworth, NJ, 07033, USA.
    Background: Herpes zoster (HZ) has a significant negative effect on the productive work life of individuals, and has been shown to be responsible for cases of absenteeism, presenteeism and decreased work effectiveness. The aim of this study was to evaluate health utility scores and associated predictors in an actively employed population of Herpes Zoster (HZ) patients with and without work time loss (WTL).

    Methods: This was a pooled analysis of the prospective, observational MASTER cohort studies, conducted in 8 countries across North America, Latin America and Asia. Read More

    Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
    Ophthalmology 2017 Mar 13;124(3):382-392. Epub 2017 Jan 13.
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
    Purpose: To evaluate the available evidence in peer-reviewed publications about the diagnosis and treatment of acute retinal necrosis (ARN).

    Methods: Literature searches of the PubMed and Cochrane Library databases were last conducted on July 27, 2016. The searches identified 216 unique citations, and 49 articles of possible clinical relevance were reviewed in full text. Read More

    [The differential diagnosis of amyotrophic lateral sclerosis and subacute herpes virus myelitis].
    Zh Nevrol Psikhiatr Im S S Korsakova 2016 ;116(11):110-113
    Burdenko Institute Neurosurgery, Moscow, Russia.
    Differential diagnosis of incurable and potentially curable neurological diseases is an urgent problem of modern neurology. The authors present a case report of subacute herpes virus myelitis, a rare complication of herpes infection by Varicella-Zoster virus. The differential diagnosis with amyotrophic lateral sclerosis is described. Read More

    Association of cigarette smoking with a past history and incidence of herpes zoster in the general Japanese population: the SHEZ Study.
    Epidemiol Infect 2017 Jan 16:1-6. Epub 2017 Jan 16.
    Public Health,Department of Social Medicine,Osaka University Graduate School of Medicine,OsakaJapan.
    Few studies have examined the impact of cigarette smoking on the risk for herpes zoster. The Shozu Herpes Zoster (SHEZ) Study is a community-based prospective cohort study over 3 years in Japan aiming to clarify the incidence and predictive and immunological factors for herpes zoster. We investigated the associations of smoking status with past history and incidence of herpes zoster. Read More

    Clinical characteristics and outcomes of varicella zoster virus infection in children with hematologic malignancies in the acyclovir era.
    Blood Res 2016 Dec 23;51(4):249-255. Epub 2016 Dec 23.
    Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.; The Catholic Blood and Marrow Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea.
    Background: Although intravenous acyclovir therapy is recommended for varicella zoster virus (VZV) infection in immunocompromised children, the clinical characteristics and outcomes of VZV infection in the acyclovir era have rarely been reported.

    Methods: The medical records of children diagnosed with varicella or herpes zoster virus, who had underlying hematologic malignancies, were retrospectively reviewed, and the clinical characteristics and outcomes of VZV infection were evaluated.

    Results: Seventy-six episodes of VZV infection (herpes zoster in 57 and varicella in 19) were identified in 73 children. Read More

    Efficacy of gabapentin for prevention of postherpetic neuralgia: study protocol for a randomized controlled clinical trial.
    Trials 2017 Jan 14;18(1):24. Epub 2017 Jan 14.
    Primary Care Research Unit of Mallorca, Baleares Health Services (IB-Salut), 07005, Palma, Spain.
    Background: Postherpetic neuralgia (PHN) is a chronic neuropathic pain that results from alterations of the peripheral nervous system in areas affected by the herpes zoster virus. The symptoms include pain, paresthesia, dysesthesia, hyperalgesia, and allodynia. Despite the availability of pharmacological treatments to control these symptoms, no treatments are available to control the underlying pathophysiology responsible for this disabling condition. Read More

    Cost of shingles: population based burden of disease analysis of herpes zoster and postherpetic neuralgia.
    BMC Infect Dis 2017 Jan 13;17(1):69. Epub 2017 Jan 13.
    College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
    Background: Around 30% of the population will experience herpes zoster (HZ), 10% of whom develop postherpetic neuralgia (PHN). Together, these illnesses produce a significant economic burden to the healthcare system.

    Methods: Administrative healthcare data collected over the period of April 1(st) 1997 to March 31(st) 2014 were analyzed to determine the healthcare system burden of HZ using direct medical costs. Read More

    Gentiana scabra Bunge. Formula for Herpes Zoster: Biological Actions of Key Herbs and Systematic Review of Efficacy and Safety.
    Phytother Res 2017 Jan 12. Epub 2017 Jan 12.
    China-Australia International Research Centre for Chinese Medicine (CAIRCCM), School of Health and Biomedical Sciences, RMIT University, Bundoora Campus, Melbourne, VIC, 3083, Australia.
    This study reviewed the biological action of key herbs and evaluated systematically the efficacy and safety of oral Gentiana formula for herpes zoster (HZ). Experimental studies relevant to HZ were identified in PubMed. Randomized controlled trials using Gentiana formula for HZ were identified from nine English and Chinese databases. Read More

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