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    1 OF 304

    Lower vaccine uptake amongst older individuals living alone: A systematic review and meta-analysis of social determinants of vaccine uptake.
    Vaccine 2017 Mar 23. Epub 2017 Mar 23.
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. Electronic address:
    Introduction: Vaccination is a key intervention to reduce infectious disease mortality and morbidity amongst older individuals. Identifying social factors for vaccine uptake enables targeted interventions to reduce health inequalities.

    Objective: To systematically appraise and quantify social factors associated with vaccine uptake amongst individuals aged ≥60years from Europe. Read More

    Epidemiology of infectious encephalitis causes in 2016.
    Med Mal Infect 2017 Mar 21. Epub 2017 Mar 21.
    Direction des maladies infectieuses, santé publique France - "European Study Group for the Infections of the Brain (ESGIB)", 94410 Saint-Maurice, France.
    We performed a literature search in the Medline database, using the PubMed website. The incidence of presumably infectious encephalitis is estimated at 1.5-7 cases/100,000 inhabitants/year, excluding epidemics. Read More

    Herpes Zoster Vaccine Coverage in Older Adults in the U.S., 2007-2013.
    Am J Prev Med 2017 Jan 26;52(1):e17-e23. Epub 2016 Oct 26.
    Center for Observational and Real-World Evidence, Merck & Co., Inc., Kenilworth, New Jersey.
    Introduction: This study aimed to assess the coverage of herpes zoster (HZ) vaccine among a large cohort of insured individuals aged ≥50 years from 2007 to 2013, and to determine the factors associated with being vaccinated for adults aged ≥60 years.

    Methods: This was a retrospective, observational study using the MarketScan® database conducted in 2015. The study population was U. Read More

    Pulsed Radiofrequency to the Dorsal Root Ganglion in Acute Herpes Zoster and Postherpetic Neuralgia.
    Pain Physician 2017 Mar;20(3):E411-E418
    Department of Anesthesiology and Pain Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Background: Latent varicella zoster virus reactivates mainly in sensory ganglia such as the dorsal root ganglion (DRG) or trigeminal ganglion. The DRG contains many receptor channels and is an important region for pain signal transduction. Sustained abnormal electrical activity to the spinal cord via the DRG in acute herpes zoster can result in neuropathic conditions such as postherpetic neuralgia (PHN). Read More

    Acupuncture plus moxibustion for herpes zoster: A systematic review and meta-analysis of randomized controlled trials.
    Dermatol Ther 2017 Mar 24. Epub 2017 Mar 24.
    China-Australia International Research Centre for Chinese Medicine & School of Health and Biomedical Sciences, RMIT University, Bundoora Campus, Melbourne, VIC, 3083, Australia.
    Herpes zoster is an acute inflammatory condition which can have a significant impact on quality of life. Antiviral therapies are effective, but do not meet patients' expectations of symptomatic relief. Acupuncture and moxibustion have been used for herpes zoster; this systematic review evaluated their efficacy and safety. Read More

    Management of adult infectious encephalitis in metropolitan France.
    Med Mal Infect 2017 Mar 20. Epub 2017 Mar 20.
    Service de médecine interne, hôpital Beaujon, AP-HP, 100, boulevard du Général-Leclerc, 92110 Clichy, France; Inserm, IAME, UMR 1137, 75018 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France. Electronic address:
    Infectious encephalitis is a severe disease leading to a high mortality and morbidity. The most frequent causes include Herpes simplex virus, Varicella Zoster virus, Listeria monocytogenes, and Mycobacterium tuberculosis. Urgent treatment is required (anti-infective therapy and nonspecific supportive care). Read More

    Asthma Status is an Independent Risk Factor for Herpes Zoster in Children: A Population-Based Cohort Study.
    Ann Med 2017 Mar 23:1-24. Epub 2017 Mar 23.
    e College of Medicine, China Medical University , Taichung , Taiwan.
    The literature regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. From the National Health Insurance Research Database, a total of 600,891 children were enrolled in this study between 2000 and 2007. Read More

    Herpes simplex virus gE/gI and US9 promote both envelopment and sorting of virus particles in the cytoplasm of neurons, two processes that precede anterograde transport in axons.
    J Virol 2017 Mar 22. Epub 2017 Mar 22.
    Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239
    Herpes simplex virus (HSV) anterograde transport in neuronal axons is vital, allowing spread from latently-infected ganglia to epithelial tissues where viral progeny are produced in numbers allowing spread to other hosts. HSV membrane proteins gE/gI and US9 initiate the process of anterograde axonal transport ensuring that virus particles are transported from the cytoplasm into the most proximal segments of axons. These proteins do not appear to be important once HSV is inside axons. Read More

    Herpes Zoster at the Site of Mohs Micrographic Surgery in an Immunocompromised Individual.
    Dermatol Surg 2017 Mar 17. Epub 2017 Mar 17.
    University of Central Florida College of Medicine, Orlando, Florida Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts.

    Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus.
    J Neurovirol 2017 Mar 20. Epub 2017 Mar 20.
    Graduate Program in Microbiology, University of California-Riverside, Riverside, CA, USA.
    Varicella zoster virus (VZV) causes varicella during acute infection and establishes latency in the sensory ganglia. Reactivation of VZV results in herpes zoster, a debilitating and painful disease. It is believed that VZV reactivates due to a decline in cell-mediated immunity; however, the roles that CD4 versus CD8 T cells play in the prevention of herpes zoster remain poorly understood. Read More

    Herpes Zoster reactivation in patients with chronic hepatitis C under treatment with directly acting antiviral agents: A case series.
    Arab J Gastroenterol 2017 Mar 17. Epub 2017 Mar 17.
    Endemic Hepatogastroenterology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
    We report a series of cutaneous Herpes Zoster (HZ) reactivation cases in patients with hepatitis C virus (HCV) infection treated with directly acting antiviral (DAA) agents. Five cases were detected among 2133 treated patients with DAAs at one of the specialized viral hepatitis treatment centers in Egypt. A control group including 2300 age and sex matched HCV patients who were previously treated with pegylated interferon and ribavirin did not show any HZ reactivation reports while on treatment. Read More

    Oral Viral Infections: Diagnosis and Management.
    Dent Clin North Am 2017 Apr;61(2):351-363
    Department of Oral and Maxillofacial Surgery, Woodhull Medical Center, 760 Broadway, Room 2C-320, Brooklyn, NY 11206, USA.
    This article focuses on common viral infections in the oral cavity with associated systemic manifestations. Discussed are the clinical features, histopathology, diagnosis, treatment, and prevention of viral infections in oral cavity. This will be a useful aid for general practitioners and other dental personnel wanting to expand their pathologic knowledge. Read More

    Antiviral and Cytostatic Evaluation of 5-(1-Halo-2-sulfonylvinyl)- and 5-(2-Furyl)uracil Nucleosides.
    Arch Pharm (Weinheim) 2017 Mar 17. Epub 2017 Mar 17.
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA.
    Transition metal-catalyzed halosulfonylation of 5-ethynyl uracil nucleosides provided (E)-5-(1-chloro-2-tosylvinyl)uridines. Tetrabutylammonium fluoride-mediated direct CH arylation of 5-iodouracil nucleosides with furan or 2-heptylfuran gave 5-furyl-substituted nucleosides without the necessity of using the organometallic substrates. These two classes of 5-substituted uracil nucleosides as well their corresponding ester derivatives were tested against a broad range of DNA and RNA viruses and the human immunodeficiency virus (HIV). Read More

    [Generalized circumscribed scleroderma with blisters].
    Hautarzt 2017 Mar 16. Epub 2017 Mar 16.
    Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland.
    The patient suffered from a 20-year course of generalized circumscribed scleroderma and presented with blisters in circumscribed areas of the affected skin. The development of subepidermal blisters has been described in all clinical forms of circumscribed scleroderma. Aetiology and pathogenesis of blister formation have not yet been clarified. Read More

    Longterm Effectiveness of Herpes Zoster Vaccine among Patients with Autoimmune and Inflammatory Diseases.
    J Rheumatol 2017 Mar 15. Epub 2017 Mar 15.
    From the University of Alabama at Birmingham, Birmingham, Alabama; Oregon Health and Science University, Portland, Oregon, USA. H. Yun received research support from Amgen. Dr. Baddley received research support from BMS. Dr. Winthrop received research support from Pfizer. Dr. Saag received research support from Amgen, and consulting fees from Amgen and Astra Zeneca. Dr. Curtis received research support from Amgen, Pfizer, Crescendo, Corrona, and consulting fees from Amgen, Janssen, Pfizer, and Corrona. H. Yun, PhD, University of Alabama at Birmingham; F. Xie, MS, University of Alabama at Birmingham; J.W. Baddley, MD, MPH, University of Alabama at Birmingham; K. Winthrop, MD, MPH, Oregon Health and Science University; K.G. Saag, MD, MSc, University of Alabama at Birmingham; J.R. Curtis, MD, MS, MPH, University of Alabama at Birmingham. Address correspondence to Dr. J.R. Curtis, 510 20th St. South, Faculty Office Towers 802D, Birmingham, Alabama 35294, USA. E-mail: Accepted for publication January 31, 2017.
    Objective: The protection duration of herpes zoster (HZ) vaccination is unclear among patients with autoimmune (AI) diseases.

    Methods: Using 2006-2013 Medicare data, HZ vaccinated patients with AI were matched 1:2 to unvaccinated HZ. Incidence rates (IR) and adjusted risk ratios over time were calculated using Poisson regression. Read More

    Safety of synthetic and biological DMARDs: a systematic literature review informing the 2016 update of the EULAR recommendations for management of rheumatoid arthritis.
    Ann Rheum Dis 2017 Mar 15. Epub 2017 Mar 15.
    Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands.
    Objectives: To assess the safety of synthetic (s) and biological (b) disease-modifying antirheumatic drugs (DMARDs) for the management of rheumatoid arthritis (RA) to inform the European League Against Rheumatism recommendations for the management of RA.

    Methods: Systematic literature review (SLR) of observational studies comparing any DMARD with another intervention for the management of patients with RA. All safety outcomes were included. Read More

    Looking back to move forward: a twenty-year audit of herpes zoster in Asia-Pacific.
    BMC Infect Dis 2017 Mar 15;17(1):213. Epub 2017 Mar 15.
    Department of Family Medicine, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemun-gu, Seoul, 130-720, Korea.
    Background: Herpes zoster (HZ) is a prevalent viral disease that inflicts substantial morbidity and associated healthcare and socioeconomic burdens. Current treatments are not fully effective, especially among the most vulnerable patients. Although widely recommended, vaccination against HZ is not routine; barriers in Asia-Pacific include long-standing neglect of adult immunisation and sparse local data. Read More

    Localization of VZV in saliva of zoster patients.
    J Med Virol 2017 Mar 11. Epub 2017 Mar 11.
    NASA- Johnson Space Center, Houston TX, 77058.
    Varicella zoster virus (VZV) in saliva from 6 herpes zoster patients and 1 chickenpox patient was found to be exclusively associated with epithelial cells by confocal microscopy. VZV localization with antibody specific to the VZV glycoprotein E was detected primarily on the membrane but was also inside the cell. Epithelial cells with VZV were still present in saliva in 1 out of two tested zoster patients after 10 months of recovery. Read More

    Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).
    Med Chem 2017 03 7. Epub 2017 Mar 7.
    Department of Applied Chemistry and Pharmaceutics, Beijing Institute of Technology, Beijing 100081. China.
    Background: All of clinic drugs for herpesvirus infections exhibit high toxicity and suffer from significant drug-resistantance. There is a great need for the development of new, effective, and safe anti-herpesvirus agents with different mechanisms of action.

    Methods: A series of novel 5-(benzylthio)-1H-1,2,3- triazole-4-carboxamides were efficiently synthesized and EC50 values against human cytomegalovirus (HCMV), varicella-zoster virus (VZV) and herpes simplex virus (HSV) were evaluated in vitro. Read More

    Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
    Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.
    Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

    Establishment of Multiplex Solid-Phase Strip PCR Test for Detection of 24 Ocular Infectious Disease Pathogens.
    Invest Ophthalmol Vis Sci 2017 Mar;58(3):1553-1559
    Center for Stem Cell and Regenerative Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
    Purpose: To establish and evaluate a new multiplex solid-phase strip polymerase chain reaction (strip PCR) for concurrent detection of common ocular infectious disease pathogens.

    Methods: A new multiplex strip PCR was established to detect 24 common ocular infectious disease pathogens: herpes simplex virus (HSV) 1, HSV2, varicella-zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus (HHV) 6, HHV7, HHV8, human T-cell lymphotropic virus (HTLV)-1, adenovirus, Mycobacterium tuberculosis, Treponema pallidum, Propionibacterium acnes (P. acnes), bacterial 16S ribosomal RNA (rRNA), Candida species (Candida sp. Read More

    Retention of finger blood flow against postural change as an indicator of successful sympathetic block in the upper limb.
    J Pain Res 2017 28;10:475-479. Epub 2017 Feb 28.
    Department of Anesthesiology, Shimane University Faculty of Medicine, Izumo, Japan.
    Background: Sympathetic block in the upper limb has diagnostic, therapeutic and prognostic utility for disorders in the upper extremity that are associated with sympathetic disturbances. Increased skin temperature and decreased sweating are used to identify the adequacy of sympathetic block in the upper limb after stellate ganglion block (SGB). Baroreflexes elicited by postural change induce a reduction in peripheral blood flow by causing sympathetic vasoconstriction. Read More

    Herpes Zoster with Post Herpetic Neuralgia Involving the Right Maxillary Branch of Trigeminal Nerve: A Case Report and Review of Literature.
    J Clin Diagn Res 2017 Jan 1;11(1):ZD40-ZD42. Epub 2017 Jan 1.
    Postgraduate Student, Department of Oral Medicine, Ragas Dental College and Hospital , Chennai, Tamil Nadu, India .
    Herpes Zoster (HZ) is an acute, self-limiting, neuro cutaneous viral infection caused by the reactivation of the Varicella Zoster Virus (VZV) that remains latent in the dorsal root ganglion. About 50% of occurrence is seen in older age groups and immunocompromised patients. Less than 5% occur in children. Read More

    A retrospective study to describe the epidemiology and outcomes of opportunistic infections after abdominal organ transplantation.
    Transpl Infect Dis 2017 Mar 8. Epub 2017 Mar 8.
    Northwestern University Transplant Outcomes Research Collaborative, Chicago, IL, USA.
    Background: Most epidemiologic studies of opportunistic infections (OI) following abdominal organ transplant (AOT) are derived prior to the era of contemporary immunosuppression and prophylaxis. These studies suggest that most OI occur within the first 6 months post transplant.

    Method: In this single-center, retrospective cohort study, we describe the epidemiology of OI in 359 consecutive AOT recipients, in the era of contemporary prophylaxis practices and alemtuzumab induction in kidney and simultaneous pancreas-kidney transplant recipients. Read More

    Social media for arthritis-related comparative effectiveness and safety research and the impact of direct-to-consumer advertising.
    Arthritis Res Ther 2017 Mar 7;19(1):48. Epub 2017 Mar 7.
    Treato Ltd, Or Yehuda, Israel.
    Background: Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure.

    Methods: The Treato platform was used to analyze all publicly available social media data including Facebook, blogs, and discussion boards for posts mentioning inflammatory arthritis (e.g. Read More

    A meta-analysis of stroke risk following herpes zoster infection.
    BMC Infect Dis 2017 Mar 7;17(1):198. Epub 2017 Mar 7.
    University of East Anglia, Norwich, United Kingdom.
    Background: The incidence of herpes zoster (HZ) is increasing and poses a significant health concern to aging populations. Several studies suggest an increased risk of stroke following zoster infection, but the results are conflicting. We conducted a systematic review and meta-analysis to determine if stroke risk is increased following HZ infection. Read More

    Safety and immunogenicity of inactivated varicella-zoster virus vaccine in adults with hematologic malignancies receiving treatment with anti-CD20 monoclonal antibodies.
    Vaccine 2017 Mar 3;35(14):1764-1769. Epub 2017 Mar 3.
    Merck & Co., Inc., Kenilworth, NJ, USA. Electronic address:
    Background: Immunocompromised patients can experience significant morbidity and occasional mortality from complications associated with herpes zoster (HZ), but live attenuated HZ vaccine is contraindicated for these patients. Inactivated zoster vaccine (ZVIN) is in development for prevention of HZ in immunocompromised patients. However, there are limited data in the literature regarding the effect of anti-CD20 monoclonal antibodies on vaccine-related cell-mediated immune response. Read More

    Economic Burden of Herpes Zoster ("culebrilla") in Latin America.
    Int J Infect Dis 2017 Mar 4;58:22-26. Epub 2017 Mar 4.
    Merck Co. & Inc., Center for Observational and Real-World Evidence, Vaccines, Kenilworth, NJ, USA.
    Background: Herpes zoster (HZ) is characterized by debilitating pain and blistering dermatomal rash. The most common complication of HZ is postherpetic neuralgia (PHN), a persistent pain that can substantially affect patients' quality of life. HZ has significant impact on patients' lives with considerable implications for healthcare systems and society. Read More

    Decreased HHV-6 IgG in Alzheimer's Disease.
    Front Neurol 2017 20;8:40. Epub 2017 Feb 20.
    Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
    Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer's disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was significantly lower in AD subjects compared to ND controls, whereas there were no differences in HSV, VZV, or CMV antibody levels between the groups. Read More

    A rare case report of acyclovir-induced immune thrombocytopenia with tongue hematomas as the first sign, and a literature review.
    BMC Pharmacol Toxicol 2017 Mar 7;18(1):12. Epub 2017 Mar 7.
    Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, People's Republic of China.
    Background: Acyclovir has been widely used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus (VZV). The common adverse effects of this drug include nausea, diarrhea, headache, dizziness and mental changes. The immune thrombocytopenia induced by acyclovir is rare. Read More

    A rash and a rare cause of unilateral diaphragmatic paralysis.
    BMJ Case Rep 2017 Mar 1;2017. Epub 2017 Mar 1.
    University Hospitals of Leicester NHS Trust, Leicester, UK.
    A 61-year-old man who was an ex-heavy smoker presented to our ambulatory care centre with a 4-week history of dyspnoea on mild exertion. 2 weeks prior to his symptoms, he had developed right-sided cervical herpes zoster for which he was prescribed oral acyclovir by his general practitioner. On examination, a rash over the right C4-5 dermatomes was noted and dullness on percussion of the right mid and lower zones with markedly reduced air entry. Read More

    Risk Factors for Skin Infections in Mycosis Fungoides.
    Dermatology 2017 Mar 2. Epub 2017 Mar 2.
    Background: Mycosis fungoides (MF) is the most frequent type of primary cutaneous natural killer and T-cell lymphoma. MF-required immunosuppressive therapies and MF-related immunosuppressive characteristics render patients with MF more prone to infections.

    Aim: To describe the clinical features of cutaneous infections observed in MF patients. Read More

    Stroke Associated With Varicella Zoster Vasculopathy: A Clinicoradiological Profile of 3 Patients.
    Neurologist 2017 Mar;22(2):64-67
    Department of Neurology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
    Introduction: Varicella zoster (VZ) vasculopathy is a rare but well recognized cause of stroke. In the absence of zoster rash and infection in remote past, the disease can pose diagnostic challenge. We report 3 cases of anterior circulation stroke occurring in close temporal relation to VZ. Read More

    Herpes zoster ophthalmicus with retrobulbar neuritis.
    Nepal J Ophthalmol 2016 Jan;8(15):78-81
    Background: Retrobulbar neuritis in Herpes Zoster Ophthalmicus (HZO) has been reported very rarely.

    Objective: To report a very rare case of HZO with retrobulbar neuritis with detailed clinical features and treatment responses.

    Case: A fifty-eight- year old male presented with Herpes zoster-retrobulbarneuritis in the left eye. Read More

    Linear Multiepitope (Glyco)peptides for Type-Specific Serology of Herpes Simplex Virus (HSV) Infections.
    ACS Infect Dis 2017 Mar 6. Epub 2017 Mar 6.
    Department of Chemistry, Faculty of Science, University of Copenhagen , Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
    Detection of type-specific antibodies is an important and essential part of accurate diagnosis, even in silent carriers of herpes simplex virus (HSV)-1 (oral) and HSV-2 (genital) infections. Serologic assays that identify HSV-1 and HSV-2 type-specific antibodies have been commercially available for more than a decade but often face problems related to cross-reactivity and similar issues. Attempts to identify type-specific peptide epitopes for use in serology for both HSV-1 and HSV-2 have been limited. Read More

    Orbital apex syndrome as a complication of herpes zoster ophthalmicus.
    BMJ Case Rep 2017 Feb 24;2017. Epub 2017 Feb 24.
    Centre for Ocular Regeneration, L V Prasad Eye Institute, Hyderabad, India.
    Orbital apex syndrome is a rare neuro-ophthalmic manifestation of herpes zoster virus infection. We report one such case with favourable outcome in an immunocompetent patient. A 60-year-old woman presented with rash in the dermatome of the left ophthalmic nerve (V1), followed by sudden loss of vision with complete left-sided external and internal ophthalmoplegia. Read More

    Comparing serum microRNA levels of acute herpes zoster patients with those of postherpetic neuralgia patients.
    Medicine (Baltimore) 2017 Feb;96(8):e5997
    aDepartment of Pain, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province bCentral Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated Nanjing University of Chinese Medicine, Nanjing, China.
    Postherpetic neuralgia (PHN) is commonly defined as pain persisting for at least 3 months after acute herpes zoster (AHZ) rash presentation. About one-tenth of all acute herpes zoster patients develop PHN. Circulating microRNAs (miRNAs) are promising biomarkers for infectious diseases; however, there has been no relationship established between circulating miRNAs and PHN to date; the aim of the present investigation was to elucidate this relationship. Read More

    Incidence of varicella zoster virus infections of the central nervous system in the elderly: a large tertiary hospital-based series (2007-2014).
    J Neurovirol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Neurology, Hospital Universitario Donostia, 20014, San Sebastian, Spain.
    The aim of the study was to describe the clinical and epidemiological characteristics of the central nervous system (CNS) infection by varicella zoster virus (VZV) in patients older than 65 years in a tertiary community hospital. We retrospectively analysed the results of cerebrospinal fluid (CSF) testing in patients older than 65 years between 2007 and 2014 with clinically suspected VZV infection with CNS involvement. Patients whose CSF samples were positive for VZV DNA were included, as were those with negative results who simultaneously presented herpes zoster and CSF or magnetic resonance imaging findings suggestive of CNS infection, and in whom other possible aetiologies had been ruled out. Read More

    The role of age-sex interaction in the development of post-herpetic neuralgia.
    Hum Vaccin Immunother 2017 Feb;13(2):376-378
    a Department of Health Sciences , University of Genoa , Genoa , Italy.
    Post-herpetic neuralgia is the most frequent complication of herpes zoster and affects up to 30% of patients. Increased age is a well-recognized risk factor, while the role of gender is highly uncertain. Little research has been performed into a possible combined effect of age and sex in post-herpetic neuralgia. Read More

    Herpes zoster correlates with increased risk of Parkinson's disease in older people: A population-based cohort study in Taiwan.
    Medicine (Baltimore) 2017 Feb;96(7):e6075
    aCollege of Medicine bDepartment of Family Medicine cCollege of Chinese Medicine dManagement Office for Health Data, China Medical University Hospital eDepartment of Healthcare Administration, College of Health Science, Asia University, Taichung fCollege of Medicine, Tzu Chi University, Hualien gGraduate Institute of Integrated Medicine, China Medical University hDepartment of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung, Taiwan.
    Little is known on the relationship between herpes zoster and Parkinson's disease in older people. This study aimed to explore whether herpes zoster could be associated with Parkinson's disease in older people in Taiwan.We conducted a retrospective cohort study using the claim data of the Taiwan National Health Insurance Program. Read More

    Genotype analysis of ORF 62 identifies varicella-zoster virus infections caused by a vaccine strain in children.
    Arch Virol 2017 Feb 15. Epub 2017 Feb 15.
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.
    This study was performed to differentiate vaccine-type strains from wild-type strains and determine the genotype of varicella-zoster virus (VZV) in 51 Korean children. A sequencing analysis of ORF 62 identified two cases of herpes zoster caused by the vaccine-type virus, without a previous history of varicella, 22 months and 5 months after VZV vaccination. The wild-type strain was identified in the remaining children. Read More

    [Hypogeusia and High Signals in the Nuclei of the Solitary Tract on MRI due to Varicella-Zoster Virus Infection: A Case Report].
    Brain Nerve 2017 Feb;69(2):173-177
    Department of Neurology, Brain Attack Center Ota Memorial Hospital.
    A 63-year-old man noticed hypogeusia after presenting hiccups for several days. He was serologically diagnosed with varicella-zoster virus (VZV) infection, but had no skin lesions typical of herpes (zoster sine herpete). Hypogeusia was confirmed by electrogustometry and the filter-paper disk method, which showed damage in the areas innervated by the cord of tympanum, glossopharyngeal nerve, and greater petrosal nerve. Read More

    Acute HIV-1 infection presenting with fulminant encephalopathy.
    Int J STD AIDS 2017 Jan 1:956462417693734. Epub 2017 Jan 1.
    1 Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
    Human immunodeficiency virus (HIV)-1 directly affects the nervous system, causes distinct neurological symptoms, and indirectly results in opportunistic infections, which include herpes virus simplex (HSV)-1, HSV-2, varicella zoster virus, and cytomegalovirus encephalitis caused by immunodeficiency. Early HIV-1 invasion of the central nervous system is also possible, and acute encephalopathy is a potentially lethal complication. We encountered a case of fulminant encephalopathy as a primary presentation of acute HIV-1 infection, in which highly active antiretroviral treatment resulted in a full clinical recovery. Read More

    [The alpha-herpesviridae in dermatology : Varicella zoster virus. German version].
    Hautarzt 2017 Mar;68(3):187-191
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien.
    The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal. Furthermore, certain associations between the occurrence of HZ and subsequent internal pathologies, as well as risk factors for HZ and new developments in vaccination against HZ will be addressed. Read More

    The alpha-herpesviridae in dermatology : Varicella zoster virus.
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.
    The second part of this publication deals with varicella zoster virus (VZV) and presents an overview of new, rare, and atypical clinical manifestations, including photolocalized varicella, hemorrhagic bullae during varicella, the implication of VZV in immunoglobulin A vasculitis, VZV-related alopecia, ulcerative varicella skin lesions, childhood herpes zoster (HZ), prolonged prodromal pains, recurrent HZ, VZV implication in burning mouth syndrome, verruciform VZV lesions, the significance of satellite lesions during HZ, and late HZ complications, either neurological or internal. Furthermore, certain associations between the occurrence of HZ and subsequent internal pathologies, as well as risk factors for HZ and new developments in vaccination against HZ will be addressed. Read More

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