16,363 results match your criteria Herpes Zoster


Corrigendum: Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus.

Front Integr Neurosci 2018 31;12:66. Epub 2019 Jan 31.

Department of Ophthalmology and of Molecular Microbiology and Genetics, Eye and Ear Foundation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

[This corrects the article DOI: 10.3389/fnint.2018. Read More

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http://dx.doi.org/10.3389/fnint.2018.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366361PMC
January 2019

Association between statin use and herpes zoster: systematic review and meta-analysis.

BMJ Open 2019 Feb 13;9(2):e022897. Epub 2019 Feb 13.

Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: Statins are commonly prescribed worldwide. In addition to being potent lipid-lowering agents, statins have immunomodulating properties that may increase the risk of varicella zoster virus reactivation. This adverse effect may have substantial public health implications. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022897DOI Listing
February 2019

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

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http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

Herpes Zoster-induced Progressive Heart Block: A Case Report.

Cureus 2018 Dec 3;10(12):e3674. Epub 2018 Dec 3.

Cardiology, Aventura Hospital and Medical Center, Aventura, USA.

Varicella-zoster virus (VZV) can produce painful, cutaneous lesions in human beings. Reactivation of this neurotropic virus leads to herpes zoster or shingles: a painful, unilateral, vesicular eruption in a restricted dermatomal distribution. Rarely, reactivation of this virus can lead to cardiac complications, such as myocarditis and even conduction abnormalities. Read More

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http://dx.doi.org/10.7759/cureus.3674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367108PMC
December 2018

Infectious complications and NK cell depletion following daratumumab treatment of Multiple Myeloma.

PLoS One 2019 13;14(2):e0211927. Epub 2019 Feb 13.

Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Treatment with Daratumumab (Dara), a monoclonal anti-CD38 antibody of IgG1 subtype, is effective in patients with multiple myeloma (MM). However, Dara also impairs the cellular immunity, which in turn may lead to higher susceptibility to infections. The exact link between immune impairment and infectious complications is unclear. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211927PLOS
February 2019

Incidence and risk factors for herpes zoster after adult liver transplantation.

Ann Surg Treat Res 2019 Feb 30;96(2):95-99. Epub 2018 Jan 30.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus, which occurs frequently in liver transplant recipients with impaired cellular immunity. The purpose of this study was to evaluate the incidence and risk factors for HZ after adult liver transplantation (LT).

Methods: In our institution, 993 patients underwent adult LT from January 1997 to December 2013. Read More

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http://dx.doi.org/10.4174/astr.2019.96.2.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358591PMC
February 2019

Mortality risk after herpes zoster infection in end-stage renal disease patients.

Clin Kidney J 2019 Feb 17;12(1):101-105. Epub 2018 Jul 17.

Department of Medicine, Augusta University, Augusta, GA, USA.

Background: End-stage renal disease (ESRD) patients have increased risk of developing herpes zoster (zoster) compared with the general population, but mortality risk is unknown. We assessed the risk of mortality in hospitalized ESRD patients with a diagnosis of zoster from the inpatient hospital files (as opposed to outpatient records) of the United States Renal Data System.

Methods: This study analyzed incident ESRD patients from 2006 to 2009. Read More

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http://dx.doi.org/10.1093/ckj/sfy058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366125PMC
February 2019
1 Read

Herpes Zoster in Pregnancy.

J Midwifery Womens Health 2019 Feb 10. Epub 2019 Feb 10.

Vanderbilt University School of Nursing, Nashville, Tennessee.

Herpes zoster (shingles) is the reactivation of dormant varicella zoster virus in individuals who previously experienced varicella infection or vaccination. Herpes zoster can occur in pregnancy, although it is rare. This case report describes the clinical presentation and diagnosis of herpes zoster and reviews current recommendations for treatment. Read More

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http://dx.doi.org/10.1111/jmwh.12953DOI Listing
February 2019
1 Read

A pathway to developing and testing quality measures aimed at improving adult vaccination rates in the United States.

Vaccine 2019 Feb 6. Epub 2019 Feb 6.

Immunization Action Coalition, St. Paul, MN, United States.

Despite recommendations for vaccinating adults and widespread availability of immunization services (e.g., pharmacy venues, workplace wellness clinics), vaccination rates in the United States remain low. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.044DOI Listing
February 2019
1 Read

Calabria: a successful experience implementing Herpes Zoster vaccination strategies.

Authors:
Sandro Giuffrida

Aging Clin Exp Res 2019 Feb 8. Epub 2019 Feb 8.

Azienda Sanitaria Provinciale di Reggio Calabria, Reggio, Italy.

Recently, the National Immunization Plan (NIP) in Italy has highlighted the importance of immunization practices also for adults, including vaccinations against influenza, Pneumococcus (PNO) and HZ. In response to the NIP, the Calabria region decided to offer HZ vaccination to the two cohorts of 65- and 70-year-old subjects. We at the Reggio Calabria Local Health Services, concentrated our efforts on addressing all the above-mentioned shortcomings and, as a first measure, we addressed the convenience problem by scheduling the HZ vaccine administration during the same visit as the pneumococcal vaccination (PCV13 vaccine). Read More

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http://dx.doi.org/10.1007/s40520-019-01145-2DOI Listing
February 2019
1 Read

Comedones appearing after herpes zoster infection: Koebner phenomenon or Wolf's isotopic response?

Eur J Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1684/ejd.2019.3504DOI Listing
February 2019

Ultrasound-guided Cervical Nerve Root Block for the Treatment of Acute Cervical Herpes Zoster: A Randomized-controlled Clinical Study.

Pain Pract 2019 Feb 7. Epub 2019 Feb 7.

Department of Anesthesiology, Central Hospital of China Aerospace Corporation, (Aerospace Clinical Medical School of Peking University), No 15 Yuquan Street, Haidian District, Beijing, China, 100049.

Objectives: To evaluate the efficacy and safety of ultrasound-guided cervical nerve root block (CRB) on acute pain and its preventive effects on post-herpetic neuralgia (PHN) in patients with cervical herpes zoster (HZ).

Methods: 140 recruiters were randomized 1:1 to receive ultrasound-guided CRB with either mixed drug liquid (treatment group) or similar looking placebo (placebo group). All patients received a 7-day course of oral antivirals treatment, pregabalin, and analgesics as needed. Read More

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http://dx.doi.org/10.1111/papr.12770DOI Listing
February 2019
1 Read

Real-World Experience with Tofacitinib in IBD at a Tertiary Center.

Dig Dis Sci 2019 Feb 7. Epub 2019 Feb 7.

Inflammatory Bowel Disease Center, University of Chicago Medicine, 5841 S. Maryland Ave, MC 4076, Chicago, IL, 60637, USA.

Background And Aims: Many inflammatory bowel disease (IBD) patients do not respond to medical therapy. Tofacitinib is a first-in-class, partially selective inhibitor of Janus kinase, recently approved for treating patients with ulcerative colitis (UC). We describe our experience with the use of tofacitinib for treatment of patients with moderate-to-severe IBD. Read More

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http://link.springer.com/10.1007/s10620-019-05492-y
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http://dx.doi.org/10.1007/s10620-019-05492-yDOI Listing
February 2019
6 Reads

Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus.

Br J Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

Background/aim: To review the long-term outcomes of penetrating keratoplasty (PKP) for corneal complications of herpes zoster ophthalmicus (HZO).

Methods: We reviewed the medical records of 53 eyes of 53 patients who underwent PKP due to corneal complications of HZO at the Kellogg Eye Center.

Results: The mean age of patients at the time of PKP was 68. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3136
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http://dx.doi.org/10.1136/bjophthalmol-2018-313602DOI Listing
February 2019
3 Reads

Comparison of the whole genome sequence of an Oka varicella vaccine from China with other Oka vaccine strains reveals sites putatively critical for vaccine efficacy.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, People's Republic of China.

Varicella-Zoster Virus (VZV) infection results in varicella mostly in children. Reactivation of the virus causes Herpes Zoster (HZ) mostly in adults. A live attenuated vaccine (vOka-Biken hereafter) was originally derived from the parental strain pOka. Read More

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http://dx.doi.org/10.1128/JVI.02281-18DOI Listing
February 2019
1 Read

The impact of childhood varicella vaccination on the incidence of herpes zoster in the general population: modelling the effect of exogenous and endogenous varicella-zoster virus immunity boosting.

BMC Infect Dis 2019 Feb 6;19(1):126. Epub 2019 Feb 6.

Department of Experimental Virology, University Hospital Jena, Jena, Germany.

Background: A controversy exists about the potential effect of childhood varicella vaccination on Herpes Zoster (HZ) incidence. Mathematical models projected temporary HZ incidence increase after vaccine introduction that was not confirmed by real-world evidence. These models assume that absence of contacts with infected children would prevent exogenous boosting of Varicella-Zoster-Virus (VZV) immunity and they do not include an endogenous VZV immunity-boosting mechanism following asymptomatic VZV reactivation. Read More

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http://dx.doi.org/10.1186/s12879-019-3759-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366068PMC
February 2019
1 Read

Paediatric Active Enhanced Disease Surveillance (PAEDS) annual report 2016: Prospective hospital-based surveillance for serious paediatric conditions

Commun Dis Intell (2018) 2019 Feb 1;43. Epub 2019 Feb 1.

Director, National Centre for Immunisation Research and Surveillance, Kids Research Institute, The Children’s Hospital at Westmead, New South Wales

Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance. PAEDS enhances data available from other Australian surveillance systems by providing prospective, detailed clinical and laboratory information on children with selected conditions. Read More

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February 2019

Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.

J Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Centre for Individualized Infection Medicine, Hannover, Germany.

Background: The tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS infections would improve our understanding of pathophysiology and end-organ damage, and, furthermore, open doors to its evaluation as a source of diagnostic and/or prognostic biomarkers.

Methods: We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 220 cerebrospinal fluid samples from patients with bacterial and viral (herpes simplex, varicella zoster, enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (anti-NMDA-R encephalitis, multiple sclerosis), and noninflamed controls (Bell's palsy, normal pressure hydrocephalus, Tourette syndrome). Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz048DOI Listing
February 2019
7 Reads

Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.

Arch Soc Esp Oftalmol 2019 Feb 1. Epub 2019 Feb 1.

Departamento de Oftalmología, Hospital Ramón y Cajal, Madrid, España.

Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. This leads to epithelial defects, ulceration and, eventually, perforation. Both herpes simplex and varicella zoster keratitis are reported to be the main causes of NK. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.01.002DOI Listing
February 2019
1 Read

Pseudohernia preceding disseminated herpes zoster.

Lancet Infect Dis 2019 Feb 30;19(2):215. Epub 2019 Jan 30.

Department of Dermatology, Mitoyo General Hospital, Kanonji, Kagawa, Japan.

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http://dx.doi.org/10.1016/S1473-3099(18)30405-5DOI Listing
February 2019

Identification of the Epstein Barr Virus portal.

Virology 2019 Jan 10;529:152-159. Epub 2019 Jan 10.

Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA.

Little is known about Epstein Barr Virus (EBV) proteins that participate in viral DNA cleavage and packaging. Genes encoding potential terminase subunit and portal protein homologs include BGRF1/BDRF1, BALF3, BFRF1A and BBRF1 respectively. EBV mutants with deletions in one or more of these genes were impaired for DNA packaging (Pavlova et al. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.003DOI Listing
January 2019
1 Read

Immunogenicity and safety of the adjuvanted recombinant zoster vaccine in patients with solid tumors, vaccinated before or during chemotherapy: A randomized trial.

Cancer 2019 Feb 1. Epub 2019 Feb 1.

GSK, Wavre, Belgium.

Background: The adjuvanted recombinant zoster vaccine (RZV) has demonstrated >90% efficacy against herpes zoster in adults ≥50 years of age and 68% efficacy in autologous hematopoietic stem cell transplant recipients ≥18 years of age. We report the immunogenicity and safety of RZV administered to patients with solid tumors (STs) before or at the start of a chemotherapy cycle.

Method: In this phase 2/3 observer-blind, multicenter study (NCT01798056), patients with STs who were ≥18 years of age were randomized (1:1) to receive 2 doses of RZV or placebo 1-2 months apart and stratified (4:1) according to the timing of the first dose with respect to the start of a chemotherapy cycle (first vaccination 8-30 days before the start or at the start [±1 day] of a chemotherapy cycle). Read More

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http://doi.wiley.com/10.1002/cncr.31909
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http://dx.doi.org/10.1002/cncr.31909DOI Listing
February 2019
16 Reads

Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis.

Authors:
Marshall Devor

Pain Rep 2018 Nov 7;3(6):e702. Epub 2018 Nov 7.

Department of Cell and Developmental Biology, Institute of Life Sciences, and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.

Introduction: Pain in herpes zoster (HZ) and postherpetic neuralgia (PHN) is traditionally explained in terms of 2 processes: irritable nociceptors in the rash-inflamed skin and, later, deafferentation due to destruction of sensory neurons in one virally infected dorsal root ganglion.

Objectives And Methods: Consideration of the evidence supporting this explanation in light of contemporary understanding of the pain system finds it wanting. An alternative hypothesis is proposed as a replacement. Read More

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http://dx.doi.org/10.1097/PR9.0000000000000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344138PMC
November 2018
1 Read

Update upon the infection risk in patients receiving TNF alpha inhibitors.

Expert Opin Drug Saf 2019 Jan 31. Epub 2019 Jan 31.

a Clinical Immunology Unit, Department of Internal Medicine , University of Genoa and Ospedale Policlinico San Martino , Genoa , Italy.

Introduction: TNF-α inhibitors can be administered either as monotherapy or in combination with other anti-inflammatory drugs or DMARDs in the treatment of chronic immune-mediated diseases. Areas covered: Patients receiving TNF-α inhibitors are at high risk of infections. An update is made on the risk of infection in patients receiving TNF-α inhibitors and the strategies for mitigating against the development of these serious adverse events. Read More

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http://dx.doi.org/10.1080/14740338.2019.1577817DOI Listing
January 2019
1 Read

[Orbital apex syndrome secondary to nasal herpes zoster virus infection: one case report].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;54(1):50-51

Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital of Jilin University, Changchun 130041, China.

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2019.01.011DOI Listing
January 2019
1 Read

Postlicensure Safety Surveillance of Recombinant Zoster Vaccine (Shingrix) - United States, October 2017-June 2018.

MMWR Morb Mortal Wkly Rep 2019 Feb 1;68(4):91-94. Epub 2019 Feb 1.

Recombinant zoster vaccine (RZV; Shingrix), an adjuvanted glycoprotein vaccine, was licensed by the Food and Drug Administration (FDA) and recommended by the Advisory Committee on Immunization Practices for adults aged ≥50 years in October 2017 (1). The previously licensed live-attenuated zoster vaccine (ZVL; Zostavax) is recommended for adults aged ≥60 years. RZV is administered intramuscularly as a 2-dose series, with an interval of 2-6 months between doses. Read More

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http://dx.doi.org/10.15585/mmwr.mm6804a4DOI Listing
February 2019
1 Read

Ramsay Hunt syndrome with pontine lesion: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14260

Department of Neurological Function Examination.

Rationale: The coexistence of Ramsay Hunt syndrome (RHS) and varicella-zoster virus (VZV) encephalitis is rare. A patient who developed RHS after being infected with VZV, along with a pontine lesion, is reported in the present study.

Patient Concerns: A 41-year-old male patient presented with his mouth askew for 7 days, and dizziness, accompanied by hearing loss for 3 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000014260DOI Listing
February 2019
1 Read
5.723 Impact Factor

CLINICAL-PATHOGENETICAL ROLE OF TOLL-LIKE RECEPTOR 2 (RS 5743708) AND INTERLEUKIN-10 (RS 1800896) GENES POLYMORPHISM IN THE COURSE OF HERPES ZOSTER IN ADULTS.

Georgian Med News 2018 Dec(285):81-86

Zaporizhzhya State Medical University, Ukraine.

The study included 50 adult patients with shingles by which analyzed the clinical course of the disease depending on the gene polymorphism of interleukin-10 (rs 1800896) and toll-like receptor 2 (rs 5743708). According to the results of our study, it was established that genotype AA of gene Toll-like receptor 2 was associated with a high risk of Varicella-Zoster virus reactivation and manifestation of herpes zoster, moderate course. Analysis of the IL-10 gene polymorphism showed that genotype TT was associated with a risk of the development severe complicated course of shingles. Read More

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December 2018
2 Reads

Central nervous system varicella zoster vasculopathy in an immunocompromised patient.

IDCases 2019 29;15:e00483. Epub 2018 Dec 29.

Infectious Diseases Department, Centro Hospitalar Universitário São João, Oporto, Portugal.

Central nervous system (CNS) vasculopathy associated with Varicella Zoster Virus (VZV) infection, usually manifesting as stroke due to ischemic lesions by involvement of small arteries, is frequently misdiagnosed. Immunocompromised patients have a particularly higher risk of severe disease and also CNS involvement during or following VZV presentations. We report a case of an 84-year-old man, with myelodysplastic syndrome, who presented with herpes zoster ophthalmicus complicated with left periocular cellulitis and an abnormal neurological exam. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348231PMC
December 2018
1 Read

Herpes zoster incidence in Germany - an indirect validation study for self-reported disease data from pretest studies of the population-based German National Cohort.

BMC Infect Dis 2019 Jan 30;19(1):99. Epub 2019 Jan 30.

Institute for Medical Epidemiology, Biometry, and Informatics (IMEBI), Medical Faculty of the Martin Luther University Halle-Wittenberg, Magdeburger Str. 8, 06110, Halle (Saale), Germany.

Background: Until now, herpes zoster (HZ)-related disease burden in Germany has been estimated based on health insurance data and clinical findings. However, the validity of self-reported HZ is unclear. This study investigated the validity of self-reported herpes zoster (HZ) and its complication postherpetic neuralgia (PHN) using data from the pretest studies of the German National Cohort (GNC) in comparison with estimates based on health insurance data. Read More

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http://dx.doi.org/10.1186/s12879-019-3691-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354372PMC
January 2019

Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study.

Bone Marrow Transplant 2019 Jan 29. Epub 2019 Jan 29.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. Read More

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http://dx.doi.org/10.1038/s41409-019-0457-9DOI Listing
January 2019
2 Reads

Herpes zoster presenting as unilateral vasculitis.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, Oregon Health and Science University, Portland, Oregon.

Vasculitis can be a primary disorder or a cutaneous manifestation of a viral infection. The present case describes an atypical localized cutaneous varicella-zoster virus infection inducing a small vessel vasculitis in a patient with multisystem sarcoidosis. Additionally, we discuss the differential diagnoses and treatment options. Read More

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November 2018
1 Read

Safety of live attenuated varicella-zoster vaccine in patients with underlying illnesses compared with healthy adults: a prospective cohort study.

BMC Infect Dis 2019 Jan 28;19(1):95. Epub 2019 Jan 28.

Kanonji Institute, Research Foundation for Microbial Diseases of Osaka University, 4-1-70, Seto-Cho, Kanonji, Kagawa, 768-0065, Japan.

Background: In Japan, freeze-dried live attenuated varicella-zoster vaccine is available for adults aged ≥50 years to prevent herpes zoster. However, limited evidence has been accumulated regarding vaccine safety for patients with underlying illnesses, who have been considered as the high-risk group for herpes zoster.

Methods: A prospective cohort study of 1200 healthy adults and 300 patients with underlying illnesses such as malignancy, diabetes mellitus, autoimmune diseases, and renal diseases was conducted. Read More

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http://dx.doi.org/10.1186/s12879-019-3719-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350288PMC
January 2019
2 Reads

Knowledge, attitude, and practice regarding infection and vaccination in patients with rheumatic diseases in China.

Hum Vaccin Immunother 2019 Jan 28. Epub 2019 Jan 28.

a Department of Rheumatology , the Third Affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Objective Vaccines including pneumococcal and influenza vaccines are recommended in patients with immunosuppressive treatment. However, vaccine coverage remains extremely low. Our study was to investigate vaccination uptake, knowledge, attitude and practice (KAP) towards certain vaccinations among these patients, and to identify the factors influencing willingness to be vaccinated. Read More

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http://dx.doi.org/10.1080/21645515.2019.1568160DOI Listing
January 2019
2 Reads

Costs of herpes zoster complications in older adults: A cohort study of US claims database.

Vaccine 2019 Feb 23;37(9):1235-1244. Epub 2019 Jan 23.

University of Colorado Anschutz Medical Campus, Aurora, CO, United States. Electronic address:

Background/objectives: Herpes zoster (HZ) incidence increases with age, and the burden of HZ is expected to grow with aging of populations worldwide. We aim to determine the incremental healthcare resource utilization and associated costs of patients with common HZ-related complications other than postherpetic neuralgia (cutaneous, neurologic and ophthalmic) compared to uncomplicated HZ.

Methods: We conducted a retrospective cohort study of commercial health insurance claims covering about 40 million immunocompetent individuals aged ≥50 years at study entry from all over the US, from 2008 to 2013, with follow-up for one year after HZ onset. Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.079DOI Listing
February 2019
2 Reads

Vaccination among Medicare-fee-for service beneficiaries: Characteristics and predictors of vaccine receipt, 2014-2017.

Vaccine 2019 Feb 22;37(9):1194-1201. Epub 2019 Jan 22.

Center for Medicare, Centers for Medicare & Medicaid Services, Baltimore, MD, United States.

Background: Vaccination coverage rates for older adults are low. To better understand utilization of Medicare vaccination benefits we examined a retrospective cohort of more than 26 million Medicare fee-for-service beneficiaries age 65 years and older from 2014 to 2017.

Methods: Multivariate logistic regression was used to obtain marginal effects (ME) describing the association between patient-level characteristics and the likelihood of vaccination. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193004
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http://dx.doi.org/10.1016/j.vaccine.2019.01.010DOI Listing
February 2019
11 Reads

Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin.

BMC Infect Dis 2019 Jan 25;19(1):91. Epub 2019 Jan 25.

GEPAMOL, Centro de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia.

Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools.

Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Read More

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http://dx.doi.org/10.1186/s12879-018-3613-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347798PMC
January 2019
3 Reads

Update in Herpes Zoster Prevention and the Role of Dermatologists

J Drugs Dermatol 2019 Jan;18(1):18-22

A recombinant vaccine (HZ/su) was approved in 2017 to prevent herpes zoster (HZ) infection and associated sequelae with greater efficacy and safety than its live precursor. Though dermatologists regularly encounter patients with HZ infection, recommendation of vaccination by dermatologists and other physicians has been minimal in past years. Overall patient awareness and utilization of the HZ vaccines has subsequently been low. Read More

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January 2019
4 Reads

The risk of infections in multiple myeloma before and after the advent of novel agents: a 12-year survey.

Ann Hematol 2019 Mar 24;98(3):713-722. Epub 2019 Jan 24.

Klinik für Innere Medizin II, Abt. Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

Infections represent a major cause of morbidity and mortality in multiple myeloma and are linked to both therapy- and disease-related factors. Although it has been suggested that the rate of infections increased since the introduction of novel agents, controversies still exist. To better assess the risk factors associated with infections in the era of novel agents, we conducted a large retrospective analysis of 479 myeloma patients treated at Jena University Hospital over a period of 12 years. Read More

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http://dx.doi.org/10.1007/s00277-019-03621-1DOI Listing
March 2019
1 Read

Quadruplex real-time PCR for rapid detection of human alphaherpesviruses.

Med Microbiol Immunol 2019 Jan 24. Epub 2019 Jan 24.

Sektion Experimentelle Virologie, Institut für Medizinische Mikrobiologie, Universitätsklinikum Jena, Hans-Knöll-Strasse 2, 07745, Jena, Germany.

Infections with the herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) as well as with the varicella-zoster virus (VZV) may take a serious course. Thus, rapid and reliable detection of these alphaherpesviruses is urgently needed. For this, we established a qualitative quadruplex real-time polymerase chain reaction (PCR) covering HSV-1, HSV-2, VZV and endogenous human glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Read More

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http://dx.doi.org/10.1007/s00430-019-00580-2DOI Listing
January 2019
1 Read

Varicella zoster virus reactivation and the increased risk of cerebrovascular accidents: the unexpected role dermatologists can play.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Dermatology Department, Hospital de Santarem EPE, Santarem.

Varicella zoster virus (VZV) primary infection usually causes varicella and its reactivation may lead to different clinical manifestations depending on the site of viral reactivation and its subsequent tissue spread. There is a growing recognition of the association between VZV reactivation and ensuing cerebrovascular accidents (CVA). The virus can spread to cerebral arteries, causing a wide clinical spectrum related to VZV vasculopathy. Read More

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August 2018
1 Read

Immune responses to zoster vaccines.

Hum Vaccin Immunother 2019 Jan 24:1-6. Epub 2019 Jan 24.

a Departments of Pediatrics , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.

There are two licensed herpes zoster vaccines. One is a live vaccine (ZVL) based on an attenuated varicella-zoster virus (VZV). The other is a recombinant vaccine (RZV) based on the VZV glycoprotein E (gE) combined with AS01B, a multicomponent adjuvant system. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
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http://dx.doi.org/10.1080/21645515.2018.1560918DOI Listing
January 2019
3 Reads

Development of herpes zoster during infliximab treatment for pediatric generalized pustular psoriasis, a case report.

Dermatol Ther 2019 Jan 23:e12838. Epub 2019 Jan 23.

Shanghai Skin Disease Hospital, Shanghai, China.

We report a 12-year-old Chinese child with generalized pustular psoriasis who was responded well to infliximab, but an adverse effect of herpes zoster occurred after the first infusion soon. The anti-viral treatment was effective and no recurrence or flaring was observed after half-year of follow-up. This case reminds us to highlight the risk of viral infection during biologic treatment on patients with psoriasis or autoimmune disease. Read More

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http://dx.doi.org/10.1111/dth.12838DOI Listing
January 2019
8 Reads

Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials.

BMJ Open 2019 Jan 21;9(1):e023600. Epub 2019 Jan 21.

Nuffield Department of Primary Care Health Sciences, Centre for Evidence-Based Medicine, University of Oxford, Oxford, UK.

Objective: To assess the benefits and harms of pregabalin in the management of neuropathic pain.

Design: Rapid review and meta-analysis of phase III, randomised, placebo-controlled trials.

Participants: Adults aged 18 years and above with neuropathic pain defined according to the International Association for the Study of Pain criteria. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02360
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http://dx.doi.org/10.1136/bmjopen-2018-023600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347863PMC
January 2019
4 Reads

CD34-selected versus unmanipulated autologous haematopoietic stem cell transplantation in the treatment of severe systemic sclerosis: a post hoc analysis of a phase I/II clinical trial conducted in Japan.

Arthritis Res Ther 2019 Jan 22;21(1):30. Epub 2019 Jan 22.

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Background: The effectiveness of autologous haematopoietic stem cell transplantation (auto-HSCT) in treating severe systemic sclerosis (SSc) is established; however, the necessity of purified CD34+ cell grafts and the appropriate conditioning regimen remain unclear. This study aimed to compare the efficacy and safety of CD34-selected auto-HSCT with unmanipulated auto-HSCT to treat severe SSc.

Methods: This study was a post hoc analysis of a phase I/II clinical trial conducted in Japan. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-019-1823-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341635PMC
January 2019
5 Reads

Relevant infections in inflammatory bowel disease, their relationship with immunosuppressive therapy and their effects on disease mortality.

J Crohns Colitis 2019 Jan 18. Epub 2019 Jan 18.

Hospital Universitari Mútua Terrassa.

Introduction: There is controversy as to whether the risk of relevant infection in IBD is related to immunosuppressants or the disease itself.

Aims: To evaluate: 1) the life-long prevalence and types of relevant infections in patients with IBD related to immunosuppressive treatment, and 2) the relationship of both infection and patient comorbidity to mortality.

Methods: Observational multicentre retrospective study of IBD patients that presented a relevant infection. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz013DOI Listing
January 2019
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Characterization of Virus-specific Immune Response During Varicella Zoster Virus Encephalitis in a Young Adult.

Clin Infect Dis 2019 Jan 19. Epub 2019 Jan 19.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia.

An immunocompetent adult received corticosteroids for chest pain, which later was clinically found to be herpes zoster (HZ). She developed severe disease and rapid viral dissemination that elicited an exceptionally strong varicella zoster virus-specific B-cell and CD8 T-cell response. Clinicians should consider atypical HZ presentation prior to corticosteroid administration. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy984DOI Listing
January 2019
3 Reads

Disseminated herpes zoster following treatment with benralizumab.

Clin Respir J 2019 Jan 21. Epub 2019 Jan 21.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.

Background: Disseminated herpes zoster infection occurs mostly in immunocompromised hosts. There have been recent reports of disseminated zoster with chemotherapeutic regimens and newer monoclonal antibodies.

Case Report: The present case describes a 61-year-old patient presenting with disseminated herpes zoster after initiation of benralizumab, an anti-IL-5 monoclonal antibody for severe persistent asthma. Read More

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http://dx.doi.org/10.1111/crj.12998DOI Listing
January 2019
10 Reads
2.197 Impact Factor

Genital Herpes Zoster as Possible Indicator of HIV Infection.

Acta Dermatovenerol Croat 2018 Dec;26(4):337-338

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) (1). It is a frequent medical condition with an incidence rate of 2-3 cases per 1000 person/years in the general population and 7-10 cases per 1000 person/years after the age of 50 (1,2). Risk factors and triggers for reactivation of HZV have not yet been determined precisely, but are likely to include malignancies, immune deficiencies, solid organ and bone marrow transplant recipients, autoimmune diseases, psychological conditions, emotional stress, human immunodeficiency virus (HIV) infection, and other patients receiving immunosuppressive therapies (1,3). Read More

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December 2018
7 Reads