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    Efficacy of baricitinib in the treatment of rheumatoid arthritis.
    Expert Opin Pharmacother 2017 Jul 24. Epub 2017 Jul 24.
    a Département de Rhumatologie , FHU ACRONIM CHU Bordeaux , Hôpital Pellegrin, 33076 Bordeaux , France.
    Introduction Although the outcome for patients with rheumatoid arthritis (RA) has improved in the past decades, adequate disease control cannot be achieved in a substantial proportion of patients. New drugs with a novel mechanism of action, may represent a valuable addition to the current armamentarium. Areas covered This review focuses on the pharmacodynamics and pharmacokinetics of baricitinib. Read More

    Infectious diseases causing autonomic dysfunction.
    Clin Auton Res 2017 Jul 20. Epub 2017 Jul 20.
    Neurology Department, Raigmore Hospital, Inverness, UK.
    Objectives: To review infectious diseases that may cause autonomic dysfunction.

    Methods: Review of published papers indexed in medline/embase.

    Results: Autonomic dysfunction has been reported in retrovirus (human immunodeficiency virus (HIV), human T-lymphotropic virus), herpes viruses, flavivirus, enterovirus 71 and lyssavirus infections. Read More

    Outpatient dermatology consultation impacts the diagnosis and management of pediatric oncology patients: A retrospective study.
    J Am Acad Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Dermatology Program, Boston Children's Hospital, Boston, Massachusetts; Department of Dermatology, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Background: The impact of dermatology consultation on the care of children with oncologic conditions is unknown.

    Objective: To review outpatient dermatology visits and the resulting impact on diagnosis and management of pediatric oncology patients.

    Method: Retrospective review of pediatric oncology patients with outpatient dermatology visits at a tertiary care center from 2008 to 2015. Read More

    Local Brain Activity Differences Between Herpes Zoster and Postherpetic Neuralgia Patients: A Resting-State Functional MRI Study.
    Pain Physician 2017 Jul;20(5):E687-E699
    Department of Anesthesiology, Zunyi Medical College, Zunyi, Guizhou, China.
    Background: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), both of which are painful diseases. PHN patients suffer chronic pain and emotional disorders. Previous studies showed that the PHN brain displayed abnormal activity and structural change, but the difference in brain activity between HZ and PHN is still not known. Read More

    Efficacy of Short-Term Spinal Cord Stimulation in Acute/Subacute Zoster-Related Pain: A Retrospective Study.
    Pain Physician 2017 Jul;20(5):E633-E645
    The First Affiliated Hospital of China Medical University, China.
    Background: Postherpetic neuralgia (PHN) is a refractory condition that impairs the patient's quality of life (QoL), it develops secondary to herpes zoster infection. Therefore, it's important to prevent the transition of acute/subacute zoster-related pain to PHN. Despite of numerous studies, the optimal intervention that reduces PHN incidence is still unknown. Read More

    Subcutaneous Injection of Triamcinolone and Lidocaine to Prevent Postherpetic Neuralgia.
    Pain Physician 2017 Jul;20(5):397-403
    Department of Pain Management, Xuanwu Hospital of Capital Medical University, Bejing, China.
    Background: Herpes zoster (HZ) is associated with inflammation of the peripheral nerves, which is considered to be an important cause of postherpetic neuralgia (PHN). Interventions aimed at reducing this inflammation could prevent PHN. One option is the epidural administration of corticosteroid and local anesthetic. Read More

    Recurrent Body Rash Warranted Second Desensitization With Acyclovir in a Myeloma Patient: A Case Report.
    J Clin Med Res 2017 Aug 1;9(8):725-728. Epub 2017 Jul 1.
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada.
    A 75-year-old woman developed a moderately severe rash about a week and a half after the start of bortezomib (Btb)-based chemotherapy for IgG lambda multiple myeloma; at the time, she was also receiving acyclovir as antiviral prophylaxis in addition to herpes zoster (HZ) vaccination. HZ reactivation rate is high in Btb recipients; therefore, the timing of antiviral prevention is critical in relation to Btb. Attempts were made to identify the offending agent based on the timing of drugs administered and the appearance of skin lesions in relation to other drugs. Read More

    Significant Associations of Neurological Complications of Herpes Zoster With Stroke in Rheumatoid Arthritis Patients.
    J Am Heart Assoc 2017 Jul 19;6(7). Epub 2017 Jul 19.
    Department of Internal Medicine and Medical Education, Taichung Veterans General Hospital, Taichung, Taiwan
    Background: Accumulating evidence suggests an increased risk of stroke after herpes zoster (HZ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. Read More

    A Case of Shingles Following Auricular Acupuncture.
    J Am Board Fam Med 2017 Jul-Aug;30(4):552-555
    From the Naval Hospital Bremerton, Bremerton, WA.
    This is a case report of an occurrence of shingles (herpes zoster [HZ]) following auricular acupuncture. The patient developed acute reactivation HZ in the V1 distribution of the right trigeminal nerve involving the forehead, scalp, and medial upper eyelid 13 days after being treated with auricular acupuncture for chronic low-back pain. The lesions were initially painless, but they clustered and became painful within 2 days. Read More

    Clinical Herpes Zoster in Antarctica as a Model for Spaceflight.
    Aerosp Med Hum Perform 2017 Aug;88(8):784-788
    Introduction: Antarctica is a useful analog for spaceflight, as both environments are remote, isolated, and with limited resources. While previous studies have demonstrated increased asymptomatic viral shedding in both the Antarctic and spaceflight environments, clinical manifestations of reactivated viral disease have been less frequently identified. We sought to identify the incidence of clinical herpes zoster from viral reactivation in the Antarctic winter-over population. Read More

    Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo-controlled phase 3 trial.
    J Dermatol 2017 Jul 17. Epub 2017 Jul 17.
    Probity Medical Research and K. Papp Clinical Research Inc., Waterloo, Ontario, Canada.
    Tofacitinib is an oral Janus kinase inhibitor. These post-hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52-week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b. Read More

    Postherpetic Neuralgia: Practical Experiences Return to Traditional Chinese Medicine.
    J Acupunct Meridian Stud 2017 Jun 28;10(3):157-164. Epub 2017 Feb 28.
    University of Newcastle, Faculty of Health, Newcastle, NSW, Australia.
    Post-herpetic neuralgia (PHN) is a complication of herpes zoster that can cause different types of pain in the affected area. It often occurs mainly in severe cases of herpes zoster. The problem is defined as a persisting pain for 90-120 days after relieving of acute phase of herpes lesions. Read More

    Herpes zoster in psoriasis patients treated with tofacitinib.
    J Am Acad Dermatol 2017 Aug;77(2):302-309
    Pfizer Inc, New York, New York.
    Background: Tofacitinib is an oral Janus kinase (JAK) inhibitor. Immunomodulatory therapies can increase the risk for herpes zoster (HZ) in patients with psoriasis.

    Objective: To evaluate the relationship between tofacitinib use and HZ risk. Read More

    Assessment of the potential public health impact of Herpes Zoster vaccination in Germany.
    Hum Vaccin Immunother 2017 Jul 14. Epub 2017 Jul 14.
    c GSK , Prinzregentenplatz 9, D-81675 München , Germany.
    The aim of this study was to compare the public health impact of introducing two Herpes Zoster (HZ) vaccines, Zoster Vaccine Live (ZVL) versus a non-live adjuvanted subunit candidate vaccine (HZ/su), in the German population aged 50+ years split into three age cohorts, i.e. 50-59, 60-69 and 70+ years, respectively. Read More

    Mimicking rashes: Use of moulage technique in undergraduate assessment at the aga khan university, Karachi.
    Educ Health (Abingdon) 2017 Jan-Apr;30(1):60-63
    Department of Family Medicine, The Aga Khan University, Karachi, Pakistan.
    Background: The use of simulated patients in student assessment is supported by the Best Evidence Medical Education and U.S. Agency for Healthcare Research and Quality, and it provides a safe and effective alternative to real patients in many situations. Read More

    Facial palsy and atrial fibrillation: a special case of Ramsay Hunt syndrome.
    BMJ Case Rep 2017 Jul 13;2017. Epub 2017 Jul 13.
    Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, Florida, USA.
    Ramsay Hunt syndrome (herpes zoster oticus) is a rare complication of latent Varicella Zoster virus infection. It can be complicated by permanent hearing loss, loss of taste and postherpetic neuralgia. Although Ramsay Hunt syndrome most prominently involves the facial nerve, a number of other cranial nerves can be involved such as the vestibulocochlear, glossopharyngeal and the vagus nerve. Read More

    Increased risk of herpes zoster in patients with coeliac disease - nationwide cohort study.
    Scand J Public Health 2017 Jul 1:1403494817714713. Epub 2017 Jul 1.
    6 Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Norway.
    Background And Aims: Clinical experience suggests that patients with coeliac disease (CD) are more prone to develop herpes zoster (HZ), but robust studies are lacking.

    Methods: We identified 29,064 patients with CD 1969-2008 using biopsy report data from Sweden's 28 pathology departments. CD was equalled to villous atrophy (Marsh histopathology grade III). Read More

    Pregabalin reduces cisplatin-induced mechanical allodynia in rats.
    J Pharmacol Sci 2017 Jun 20. Epub 2017 Jun 20.
    Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan. Electronic address:
    Although cisplatin (CDDP) is a key drug in cancer chemotherapy, CDDP-induced peripheral neuropathy is a dose-limiting factor. We previously reported that CDDP-induced peripheral neuropathy, which progressed from allodynia to hypoalgesia, was ameliorated by the administration of CDDP to rats at a specific time. However, mechanical allodynia cannot be prevented therapeutically. Read More

    Bilateral herpes zoster in a patient with end-stage kidney disease.
    Int Med Case Rep J 2017 19;10:209-212. Epub 2017 Jun 19.
    Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Shimotsuke-Shi, Tochigi, Japan.
    Herpes zoster (HZ) is caused by the reactivation of a latent varicella-zoster virus (VZV) infection within the cranial or dorsal root ganglia. The cutaneous lesions of HZ are typically limited to a single dermatome, while non-contiguous HZ involving two or more dermatomes is a very rare clinical entity. In this report, we describe a case of HZ involving the left and right side of the abdomen corresponding to the T11 dermatome in a 63-year-old man on chronic peritoneal dialysis. Read More

    A cross-sectional study of the knowledge, attitude, and practice of patients aged 50 years or above towards herpes zoster in an out-patient setting.
    Hong Kong Med J 2017 Jul 7. Epub 2017 Jul 7.
    Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
    Introduction: There has been limited research on the knowledge of and attitudes about herpes zoster in the Hong Kong population. This study aimed to investigate the knowledge, attitude, and practice of patients aged 50 years or above towards herpes zoster and its vaccination.

    Methods: This was a cross-sectional study in the format of a structured questionnaire interview carried out in Sai Ying Pun Jockey Club General Outpatient Clinic in Hong Kong. Read More

    Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
    J Med Chem 2017 Jul 6. Epub 2017 Jul 6.
    Medicinal Chemistry, Rega Institute for Medical Research, KU Leuven , Herestraat 49, 3000 Leuven, Belgium.
    Acyclic nucleosides containing a 3-fluoro-2-(phosphonomethoxy)propyl (FPMP) side chain are known to be moderately potent antihuman immunodeficiency virus (HIV) agents, while being completely devoid of antiviral activity against a wide range of DNA viruses. The derivatization of the phosphonic acid functionality of FPMPs with a diamyl aspartate phenoxyamidate group led to a novel generation of compounds that not only demonstrate drastically improved antiretroviral potency but also are characterized by an expanded spectrum of activity that also covers hepatitis B and herpes viruses. The best compound, the (S)-FPMPA amidate prodrug, exerts anti-HIV-1 activity in TZM-bl and peripheral blood mononuclear cells at low nanomolar concentrations and displays excellent potency against hepatitis B virus (HBV) and varicella-zoster virus (VZV). Read More

    Amenamevir, a novel helicase-primase inhibitor, for treatment of herpes zoster: A randomized, double-blind, valaciclovir-controlled phase 3 study.
    J Dermatol 2017 Jul 5. Epub 2017 Jul 5.
    Maruho Co., Ltd, Kyoto, Japan.
    Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent other than nucleoside compounds, such as aciclovir, valaciclovir and famciclovir. This study is the first randomized, double-blind, valaciclovir-controlled phase 3 study to evaluate the efficacy and safety of amenamevir in Japanese patients with herpes zoster when treated within 72 h after onset of rash. A total of 751 patients were randomly assigned to receive either amenamevir 400 mg or 200 mg p. Read More

    Incidence of herpes zoster amongst adults varies by severity of immunosuppression.
    J Infect 2017 Jul 1. Epub 2017 Jul 1.
    Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. Electronic address:
    Objectives: We examined the incidence of herpes zoster in immunocompromised adults (≥18 years) with different severities of immunosuppression and assessed the prevalence of complications and of various kinds of healthcare resource utilisation.

    Methods: German claims data from more than ten million adults were used to calculate annual incidence rates of herpes zoster for the years 2006-2012 and to analyse the prevalence of complications, physician visits, hospitalisations, and antiviral and analgesic treatments using a cohort design. The analyses were stratified by age, sex, and severity of immunosuppression, defined by immunocompromising conditions and drug therapies. Read More

    Effect of Zhuang medicine medicated thread moxibustion on protomics in serum of postherpetic neuralgia patient with Herpes zoster.
    Pak J Pharm Sci 2017 May;30(3(Special)):1063-1067
    Guangxi University of Traditional Chinese Medicine, Nanning Guangxi, China.
    The aim of this study was to observe the effect of Zhuang medicine medicated thread moxibustion on protomics in serum of postherpetic neuralgia patient with herpes zoster and discuss the action mechanism of Zhuang medicine medicated thread moxibustion in treating postherpetic neuralgia (PHN). Patients were divided into three groups in clinic, namely the pre-treatment group (n=20), post-treatment group (n=20) and healthy group (n=20), patients meeting corresponding conditions were recruited in the voluntary principle to accept PHN pain evaluation and protomics tests respectively. Compared with the pre-treatment group, visual analogue scale (VAS) in post-treatment group obviously reduced, protomics indexes like MFG-ES, Lymphotoxin beta/TNFSF3, IL-19, Neuritin, NCAM-1/CD56 and PECAM-1/CD31 obviously changed. Read More

    Human varicella zoster virus is not present in the semen of a man affected by chickenpox during the in vitro fertilisation of his wife.
    Andrologia 2017 Jul 3. Epub 2017 Jul 3.
    Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
    Human varicella zoster virus (VZV) is a member of the herpes virus family and affects humans only. Information about the presence of the virus in the semen samples of men affected by chickenpox is rather limited in the literature. Here, we reported a husband was affected by VZV during in vitro fertilisation treatment of his wife treated in our centre. Read More

    Oral shedding of human herpesviruses in renal transplant recipients.
    Clin Oral Investig 2017 Jul 1. Epub 2017 Jul 1.
    Division of Pathology, Department of Stomatology, University of São Paulo School of Dentistry, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo, SP, Brazil.
    Objective: To describe the shedding profile of human herpesviruses in the saliva of renal transplant recipients.

    Methods: This is a prospective case-control study of 50 renal transplant recipients and control group of 50 individuals (non-transplanted and immunocompetent). Mouthwash samples were collected via oral rinse and then submitted to screening for the presence of eight types of herpesviruses by using multiplex PCR. Read More

    Risk Factors for Secondary Glaucoma in Herpetic Anterior Uveitis.
    Am J Ophthalmol 2017 Jun 27. Epub 2017 Jun 27.
    University Medical Center Groningen, University of Groningen, Department of Ophthalmology, P. O. Box 30001, 9700 RB Groningen, the Netherlands; W.J. Kolff Institute, Graduate School of Medical Sciences, University of Groningen, the Netherlands.
    Purpose: To determine the incidence of elevated intraocular pressure (IOP) and secondary glaucoma in herpetic anterior uveitis (AU), due to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of glaucoma.

    Design: Retrospective, observational cohort study.

    Methods: Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included. Read More

    Herpes Zoster Involving the Second Division of the Trigeminal Nerve: Case Report and Literature Review.
    J Endod 2017 Jun 26. Epub 2017 Jun 26.
    Department of Endodontics, The Dental College of Georgia, Augusta University, Augusta, Georgia. Electronic address:
    Herpes zoster along the maxillary division of the trigeminal nerve is a rare condition that is caused by reactivation of the varicella zoster virus that resides within the trigeminal ganglion after the primary infection of chickenpox. The disease may be manifested as a toothache during its prodromal stage. The active stage of the disease is characterized by the appearance of a vesicular rash. Read More

    The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review.
    J Endod 2017 Jun 26. Epub 2017 Jun 26.
    Department of Clinic of Oral Surgery, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
    Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies.

    Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus. Read More

    Medical and surgical management of Pasteurella canis infectious keratitis.
    IDCases 2017 29;9:42-44. Epub 2017 May 29.
    Ohio State University Havener Eye Institute Department of Ophthalmology and Visual Science, USA.
    Introduction: We describe a case of refractory Pasteurella Canis keratitis that initially failed antimicrobial treatment but was successfully treated with a conjunctival flap followed by a penetrating keratoplasty.

    Case Discussion: A 70-year-old male had persistent corneal edema related to previous herpes zoster keratouveitis with visual acuity of 20/400. An endothelial keratoplasty was performed with improvement in vision to 20/25. Read More

    Severe atypical herpes zoster as an initial symptom of fatal myelodysplastic syndrome with refractory anemia and blast excess (RAEB II).
    Clin Cosmet Investig Dermatol 2017 18;10:195-198. Epub 2017 May 18.
    Department of Dermatology and Dermatologic Surgery, Medical Institute of Ministry of Interior (MVR), Sofia, Bulgaria.
    Herpes zoster is a common disease caused due to varicella zoster virus (VZV) infection with increasing incidence by age. If the patient has a severe, extended, or treatment-recalcitrant course of herpes zoster, this must be a red flag to search for underlying pathologies. Here, we report about a 64-year-old male patient with diabetes, who came to our emergency department because of general malaise, fever, chills, and a pronounced nuchal and facial swelling on the left side. Read More

    Latent virus reactivation in astronauts on the international space station.
    NPJ Microgravity 2017 12;3:11. Epub 2017 Apr 12.
    NASA Johnson Space Center, Mail code SK, 2101 NASA Parkway, Houston, TX 77058 USA.
    Reactivation of latent herpes viruses was measured in 23 astronauts (18 male and 5 female) before, during, and after long-duration (up to 180 days) spaceflight onboard the international space station . Twenty age-matched and sex-matched healthy ground-based subjects were included as a control group. Blood, urine, and saliva samples were collected before, during, and after spaceflight. Read More

    Varicella vaccination - the global experience.
    Expert Rev Vaccines 2017 Jul 13:1-11. Epub 2017 Jul 13.
    f Global Medical Affairs Rota & MMRV, GSK , Wavre , Belgium.
    Introduction: Varicella, although a frequently benign childhood disease, nevertheless represents a considerable health burden. WHO recommends including varicella vaccines in universal routine vaccination programs, and maintaining coverage >80%. Many countries have successfully introduced varicella vaccination and have benefited from lower disease burden, but many others have not adopted the vaccine. Read More

    Long-term risk of infection in patients with Crohn's disease on anti-TNF treatment: A prospective single center cohort study in China.
    J Dig Dis 2017 Jun 23. Epub 2017 Jun 23.
    Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China.
    Background: Anti-TNF agents have demonstrated to greatly improve management strategies for inflammatory bowel disease (IBD). Clinical trials and registry studies in Western countries have shown that infections and malignancy are the most concerned complications of anti-TNF treatment. However, data derived from clinical practice in China are limited. Read More

    Varicella-zoster meningovasculitis in a multiple sclerosis patient treated with natalizumab.
    Mult Scler 2017 Jun 1:1352458517711569. Epub 2017 Jun 1.
    Servei de Neurologia-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Barcelona, Spain.
    Background: Natalizumab is associated with the occasional occurrence of progressive multifocal leukoencephalopathy (PML). While natalizumab-associated PML is well described in multiple sclerosis (MS) patients, herpes and other infections have rarely been reported.

    Objective: To report a case of varicella-zoster (VZV) meningovasculitis in a MS patient treated with natalizumab. Read More

    Trends in Diagnoses Among Hospitalizations of HIV-Infected Children and Adolescents in the US: 2003-2012.
    Pediatr Infect Dis J 2017 Jun 20. Epub 2017 Jun 20.
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
    Objective: Using data from 2003-2012, we updated a previous analysis of trends in hospitalizations of HIV-infected children and adolescents in the US.

    Methods: We used data from the Kids´ Inpatient Database of the Healthcare Cost and Utilization Project to derive nationally representative estimates of the number of hospitalizations and the rates per 1000 hospitalizations of select discharge diagnoses and procedures in 2003, 2006, 2009, and 2012 among HIV-infected and HIV-uninfected children and adolescents ≤18 years, excluding hospitalizations for conditions related to pregnancy/delivery and neonatal diagnoses. We also examined trends in the prevalence of select discharge diagnoses and procedures using multivariable logistic regression models. Read More

    Role of JNK pathway in varicella-zoster virus lytic infection and reactivation.
    J Virol 2017 Jun 21. Epub 2017 Jun 21.
    Division of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
    Mechanisms of neuronal infection by varicella-zoster virus (VZV) have been challenging to study due to the relatively strict human tropism of the virus and the paucity of tractable experimental models. Cellular mitogen activated protein kinases (MAPKs) have been shown to play a role in VZV infection of non-neuronal cells, with distinct consequences on infectivity in differing cell types. Here, we utilize several human neuronal culture systems to investigate the role of one such MAPK, the c-Jun N-terminal kinase (JNK), in VZV lytic infection and reactivation. Read More

    Trends in Nationwide Herpes Zoster Emergency Department Utilization From 2006 to 2013.
    JAMA Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Harvard Medical School, Boston, Massachusetts4Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.
    Importance: The effect of vaccination on emergency department (ED) utilization for herpes zoster (HZ) has not been examined to date.

    Objective: To determine trends in US ED utilization and costs associated with HZ.

    Design, Setting, And Participants: The Nationwide Emergency Department Sample data set was examined for temporal trends in the number of visits and costs for treatment of HZ in EDs in the United States from January 1, 2006, through December 31, 2013. Read More

    The spectrum of aseptic central nervous system infections in southern Germany - demographic, clinical and laboratory findings.
    Eur J Neurol 2017 Aug 21;24(8):1062-1070. Epub 2017 Jun 21.
    Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
    Background And Purpose: Aseptic infections of the central nervous system (CNS) are frequently observed in Germany. However, no study has systematically addressed the spectrum of aseptic CNS infections in Germany.

    Methods: Data on 191 adult patients diagnosed from January 2007 to December 2014 with aseptic meningitis or encephalitis/meningoencephalitis at our hospital were collected by chart review and analyzed for demographic, clinical and laboratory findings. Read More

    Cutaneous varicella zoster virus infection following zoster vaccination: report of post-vaccination herpes zoster skin infection and literature review of zoster vaccination efficacy and guidelines.
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, University of California San Diego, La Jolla, California.
    BackgroundHerpes zoster vaccine is currently recommended in the United States for immune competent individuals ≥60 years. The efficacy of the herpes zoster vaccine decreases with age and with time following vaccination.PurposeAn elderly man with herpes zoster following vaccination is described. Read More

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