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    Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine.
    Ann Pharmacother 2018 Feb 1:1060028018758431. Epub 2018 Feb 1.
    3 Saint Joseph Hospital, Denver, CO, USA.
    Objectives: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles.

    Data Sources: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. Read More

    [Varicella and herpes zoster: challenges for public health].
    Salud Publica Mex 2017 Nov-Dec;59(6):650-656
    MSD México. Ciudad de México, México.
    Objective: To evaluate the epidemiological behavior of varicella and herpes zoster (HZ) to determine the need of health policies to diminish prevalence and avoid complications.

    Materials And Methods: To assess frequency, we analyzed data from the National Information System for Epidemiological Surveillance (SUIVE) from 2000 to 2013; to assess the discharge data of varicella and HZ, we evaluated information from the National System of health information (Sinais).

    Results: The average annual cases of chickenpox were 296 733, 57% mostly children under 9 years, most of them from March to May. Read More

    Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
    Drugs Today (Barc) 2017 Nov;53(11):573-584
    Department of Virology, University of Toyama, Toyoma, Japan.
    Valacyclovir and famciclovir enabled successful systemic therapy for treating herpes simplex virus (HSV) and varicella zoster virus (VZV) infection by their phosphorylation with viral thymidine kinase. Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands. The HPIs amenamevir and pritelivir have a novel mechanism of action, once-daily administration with nonrenal excretory characteristics, and clinical efficacy for genital herpes. Read More

    Efficacy and safety of combination therapy with prednisolone and oral tacrolimus for progressive interstitial pneumonia with systemic sclerosis: a retrospective study.
    Mod Rheumatol 2018 Feb 14:1-19. Epub 2018 Feb 14.
    a Department of Internal Medicine (IV) , Osaka Medical College , Takatsuki , Osaka , Japan.
    Objectives: We retrospectively investigated efficacy and safety of combination therapy with prednisolone (PSL) and tacrolimus (TAC) for progressive interstitial pneumonitis with systemic sclerosis (SSc-PIP).

    Methods: We studied 11 patients with SSc-PIP who received combination therapy with PSL (0.5 mg/kg/day) and TAC (3 mg/day). Read More

    Detection of HPV16 in Esophageal Cancer in a High-Incidence Region of Malawi.
    Int J Mol Sci 2018 Feb 12;19(2). Epub 2018 Feb 12.
    Department of Gynecology, Jena University Hospital-Friedrich-Schiller-University, 07747 Jena, Germany.
    This study was designed to explore the role of human papillomavirus (HPV) in esophageal squamous cell carcinoma (ESCC). Fifty-five patients receiving diagnostic upper gastrointestinal endoscopy at Zomba Central Hospital or Queen Elizabeth Hospital in Blantyre (Malawi) in 2010, were included in our study. Formalin-fixed paraffin-embedded biopsies were collected for histopathological diagnosis. Read More

    Cytoskeletons in the Closet-Subversion in Alphaherpesvirus Infections.
    Viruses 2018 Feb 13;10(2). Epub 2018 Feb 13.
    Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
    Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Read More

    Well-Appearing Newborn With a Vesiculobullous Rash at Birth.
    Pediatrics 2018 Feb 6. Epub 2018 Feb 6.
    Pediatric Hospital Medicine, and.
    A term, appropriate-for-gestational-age, male infant born via normal spontaneous vaginal delivery presented at birth with a full-body erythematous, vesiculobullous rash. He was well-appearing with normal vital signs and hypoglycemia that quickly resolved. His father had a history of herpes labialis. Read More

    Mucosal healing and the risk of serious infections in patients with celiac disease.
    United European Gastroenterol J 2018 Feb 24;6(1):55-62. Epub 2017 Apr 24.
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
    Background: Patients with celiac disease (CD) are at increased risk of certain infections, but it is unknown if mucosal healing influences this risk.

    Methods: We collected data on 29,096 individuals with CD (equal to villous atrophy) through Sweden's 28 pathology departments undergoing biopsy 1969-2008. Through the Swedish Patient Register we obtained information on any infection and specifically sepsis, streptococcal infection, influenza,, herpes zoster and pneumococcal infection up until December 2009. Read More

    [Trigeminal Herpes Zoster Presenting with High-intensity Signals for the Spinal Trigeminal Nucleus and Tract on Diffusion-weighted Image: A Case Report of Stroke Mimic].
    Brain Nerve 2018 Feb;70(2):161-164
    Department of Neurology, Brain Attack Center, Ota Memorial Hospital.
    A 50-year-old woman was admitted to our hospital with dysesthesia on the right upper portion of her face and a headache. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed high-intensity signals in the dorsolateral portion of the medulla oblongata. She was diagnosed with lateral medullary infarction and was intravenously treated with sodium ozagrel. Read More

    Herpes Zoster and Postherpetic Neuralgia: Prevention and Management.
    Am Fam Physician 2017 Nov;96(10):656-663
    Nellis Family Medicine Residency, Mike O'Callaghan Federal Medical Center, Nellis Air Force Base, NV, USA.
    Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Read More

    Incidence and costs of herpes zoster and postherpetic neuralgia in German adults aged ≥50 years: A prospective study.
    J Infect 2018 Feb 8. Epub 2018 Feb 8.
    GSK, Avenue Fleming 20, 1300 Wavre, Belgium. Electronic address:
    Objectives: Herpes zoster (HZ) mainly affects elderly people and immunocompromised individuals. HZ is usually characterized by a unilateral painful skin rash. Its most common complication, postherpetic neuralgia (PHN), may cause chronic debilitating pain. Read More

    Multi-viral canaliculitis: case report and review of literature.
    Int Ophthalmol 2018 Feb 9. Epub 2018 Feb 9.
    Jhaveri Microbiology Laboratory, L. V. Prasad Eye Institute, Hyderabad, 34, India.
    Aim: To report an atypical case of multiple viruses causing canaliculitis.

    Methods: Case report of a young female presenting with atypical course of refractory unilateral canaliculitis with complete mid-bicanalicular obstructions. Canalicular scrapings were subjected to immunofluorescence techniques and polymerase chain reactions to identify the viruses. Read More

    Safety of live-attenuated measles-mumps-rubella and herpes zoster vaccination in multiple myeloma patients on maintenance lenalidomide or bortezomib after autologous hematopoietic cell transplantation.
    Bone Marrow Transplant 2018 Feb 9. Epub 2018 Feb 9.
    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
    Attenuated live virus vaccinations are generally recommended 24 months following hematopoietic cell transplantation (HCT) in patients not receiving immunosuppressive therapy. To date, there are no data regarding the safety of live-attenuated herpes zoster or measles-mumps-rubella (MMR) vaccinations in multiple myeloma patients on maintenance lenalidomide or bortezomib following autologous HCT. One hundred thirty-seven multiple myeloma patients on maintenance lenalidomide or bortezomib post-auto-HCT who received either MMR or herpes zoster vaccine were analyzed and any adverse events documented in the medical record in the 42 days following vaccination were recorded. Read More

    Herpes zoster chronification to postherpetic neuralgia induces brain activity and grey matter volume change.
    Am J Transl Res 2018 15;10(1):184-199. Epub 2018 Jan 15.
    Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical UniversityZunyi, Guizhou, China.
    Objective: Herpes zoster (HZ) can develop into postherpetic neuralgia (PHN), which is a chronic neuropathic pain (NP). Whether the chronification from HZ to PHN induced brain functional or structural change is unknown and no study compared the changes of the same brains of patients who transited from HZ to PHN. We minimized individual differences and observed whether the chronification of HZ to PHN induces functional and pain duration dependent grey matter volume (GMV) change in HZ-PHN patients. Read More

    Localized Trichiasis Causing Focal Full-Thickness Corneal Edema, Endothelial Cell Loss, and Corneal Scarring Requiring Penetrating Keratoplasty.
    Middle East Afr J Ophthalmol 2017 Oct-Dec;24(4):216-218
    Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.
    The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Read More

    Safety, and Humoral and Cell-mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis.
    J Rheumatol 2018 Feb 1. Epub 2018 Feb 1.
    From the Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. J.H. Koh, MD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.H. Kim, MD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.K. Kwok, MD, PhD; Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, and Rheumatism Research Center, College of Medicine, The Catholic University of Korea; J.H. Ju, MD, PhD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.H. Park, MD, PhD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, and Rheumatism Research Center, College of Medicine, The Catholic University of Korea; J. Lee, MS, Rheumatism Research Center, College of Medicine, The Catholic University of Korea. Address correspondence to Prof. S.H. Park, 222 Banpo-daero, Seocho-gu, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea 06545. E-mail: Accepted for publication November 8, 2017.
    Objective: To examine humoral and cellular immune responses induced by a live attenuated herpes zoster (HZ) vaccine in patients with rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients.

    Methods: This was an observational study of a live attenuated HZ vaccine in 41 patients with RA receiving conventional disease-modifying antirheumatic drugs (cDMARD) and/or low-dose glucocorticoids (GC) and in 28 patients with OA. Blood samples were obtained before and at 12 weeks after HZ vaccination. Read More

    Guillain-Barré syndrome following varicella-zoster virus infection.
    Eur J Clin Microbiol Infect Dis 2018 Mar 6;37(3):511-518. Epub 2018 Feb 6.
    Departments of Neurology and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    We describe the frequency, clinical features, and electrophysiological and immunological phenotypes of Guillain-Barré Syndrome (GBS) patients treated at a single institution in Bangladesh who had preceding chicken pox (primary Varicella-zoster virus [VZV] infection) within 4 weeks of GBS onset. A literature review of GBS cases preceding VZV infection is also provided. Diagnosis of GBS was based on the National Institute of Neurological Disorders and Stroke criteria for GBS. Read More

    Infectious meningitis and encephalitis in adults in Denmark: A prospective nationwide observational cohort study (DASGIB).
    Clin Microbiol Infect 2018 Jan 30. Epub 2018 Jan 30.
    Department of Infectious Diseases, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark.
    Objectives: To monitor epidemiological trends of infectious meningitis (bacterial and viral) and encephalitis in Denmark.

    Methods: Nation-wide prospective observational study of all cases with proven community-acquired infectious meningitis and encephalitis in adults treated in all departments of infectious diseases in Denmark from 1of January 2015 to 30of June 2016. We included data on symptoms, aetiology, treatment and outcome assessed by the Glasgow Outcome Scale (GOS) 30-days after discharge. Read More

    Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine.
    J Infect Dis 2018 Feb 2. Epub 2018 Feb 2.
    Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora.
    We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Read More

    SUNCT like syndrome preceding acute ophthalmic- distribution zoster: A case report and review of the literature.
    Clin Neurol Neurosurg 2018 Jan 31;166:107-109. Epub 2018 Jan 31.
    Johannes- Wesling- Klinikum Minden, Dept. of Neurology, Ruhr-University Bochum, Hans-Nolte Str. 1, 32429 Minden, DE, Germany.
    Background: SUNCT like syndrome has been observed as a post zoster condition, as a syndrome associated with overt ophthalmic zoster after appearance of herpetic lesions and in varicella zoster virus meningoencephalitis without rash. However, SUNCT like syndrome fully consistent and congruent with the criteria of the ICHD immediately before onset of an ophthalmic-distribution zoster has not been reported.

    Case Presentation: We report 73-year-old patient with a SUNCT like syndrome as the first presentation of an acute ophthalmic-distribution zoster. Read More

    Paraspinal muscle involvement in herpes zoster-induced abdominal wall pseudohernia revealed by electrophysiological and radiological studies.
    J Neurol Sci 2018 Feb 19;385:89-91. Epub 2017 Dec 19.
    Department of Neurology, Tokyo Teishin Hospital, Tokyo, Japan.
    Segmental zoster paresis is an uncommon complication of herpes zoster, and abdominal wall pseudohernia is rare. Previous reports have emphasized the involvement of anterior rami of spinal nerves, while the involvement of posterior rami has been less frequently reported. We aimed to elucidate the involvement of posterior rami of spinal nerves in abdominal wall pseudohernia. Read More

    Herpes zoster at the vaccination site in immunized healthy children.
    Pediatr Dermatol 2018 Feb 6. Epub 2018 Feb 6.
    Dermatology Program, Boston Children's Hospital, Boston, MA, USA.
    In this case series, we report seven immunized healthy children without underlying immunodeficiency who presented with herpes zoster that correlated with varicella-zoster vaccination site. The morphology of the lesions included erythematous papules, pseudovesicles, and plaques, with associated pain in two and pruritus in three patients; systemic symptoms ranged from none to low-grade fevers, upper respiratory symptoms, and joint pain. These cases highlight the clinical, diagnostic, and therapeutic implications of herpes zoster in vaccinated children. Read More

    Aetiological study of viruses causing acute encephalitis syndrome in North West India.
    Indian J Med Microbiol 2017 Oct-Dec;35(4):529-534
    Department of Microbiology and Immunology, Advanced Basic Sciences and Clinical Research Laboratory, ICMR Grade 1/ DHR State, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.
    Context: Acute encephalitis syndrome (AES) is a serious public health problem, caused mainly by viruses. However, the profile of viruses causing AES in Rajasthan is not well characterised.

    Aims: The present study was undertaken to identify the viruses causing AES and develop diagnostic algorithm so as to help in improved diagnosis, treatment, prevention and control. Read More

    Active Herpes Zoster Infection Involving Lumbosacral Dermatome, an Unusual Site of Manifestation and Incidental Finding in Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan.
    World J Nucl Med 2018 Jan-Mar;17(1):52-55
    Department of Nuclear Medicine, PGIMER, Chandigarh, India.
    Herpes zoster virus reactivation in the lumbosacral dermatomal distribution is an unusual site of manifestation and atypical in presentation than its usual sites in thoracolumbar (D3-L2) and facial (V1) dermatomes. Here, we are reporting a patient of marginal zone lymphoma who on fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography scan performed for chemotherapy response evaluation showed hypermetabolic cutaneous and subcutaneous lesions in the right vulva and posteromedial aspect of the right thigh along with ipsilateral pelvic lymph nodes involvement as an incidental finding. Subsequently, FDG active lesions were considered to be as herpes zoster virus reactivation rather than the recurrence of lymphoma and treated with antiviral drug. Read More

    The Prevalence and Risk for Herpes Zoster Infection in Adult Patients With Diabetes Mellitus in the Canadian Primary Care Sentinel Surveillance Network.
    Can J Diabetes 2017 Nov 20. Epub 2017 Nov 20.
    Department of Family Medicine, Centre for Studies in Primary Care, Queen's University, Kingston, Ontario, Canada.
    Objectives: Herpes zoster (HZ) is a common infection in Canada that can result in serious and long-term complications. People with diabetes may be at an increased risk for HZ. The objectives of this study were to develop and validate a case definition of HZ diagnosis based on electronic medical records; determine a prevalence estimate for HZ in adult patients in the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) and assess the association between HZ and diabetes. Read More

    Age-dependent trigeminal and female-specific lumbosacral increase in herpes zoster distribution in the elderly.
    J Dermatol Sci 2018 Jan 31. Epub 2018 Jan 31.
    Department of Virology, University of Toyama, Toyama, 930-0194, Japan.
    Background: Varicella-zoster virus causes herpes zoster (HZ) along specific dermatomes, but the effects of age and sex on HZ distribution are unclear.

    Objective: We investigated the age- and sex-dependent distribution characteristics of HZ.

    Methods: Patients with HZ were monitored by members of the Miyazaki Dermatologist Society. Read More

    Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study.
    Clin Ophthalmol 2018 11;12:113-118. Epub 2018 Jan 11.
    Vasculitis Clinic, Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.
    Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly and can cause irreversible blindness and aortitis. Varicella zoster (VZ), which is potentially preventable by vaccination, has been proposed as a possible immune trigger for GCA, but this is controversial. The incidence of GCA varies widely by country. Read More

    Vaccines for the elderly: current use and future challenges.
    Immun Ageing 2018 22;15. Epub 2018 Jan 22.
    Universität Innsbruck, Institute for Biomedical Aging Research, Rennweg 10, 6020 Innsbruck, Austria.
    Age-related changes of the immune system contribute to increased incidence and severity of infections in the elderly. Vaccination is the most effective measure to prevent infections and vaccination recommendations in most countries include specific guidelines for the elderly. Vaccination against influenza andis usually recommended for persons with underlying diseases and for the elderly with heterogeneous age limits between ≥ 50 years and ≥ 65 years. Read More

    Effectiveness of continuous epidural analgesia on acute herpes zoster and postherpetic neuralgia: A retrospective study.
    Medicine (Baltimore) 2018 Feb;97(5):e9837
    Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
    Despite early treatment of herpes zoster (HZ), postherpetic neuralgia (PHN) can persist. This study was designed to compare the therapeutic and pain relief effects of continuous epidural analgesia (CEA) on the chronic phase as well as the acute phase of HZ with standard medical treatment.Medical records of 227 patients with moderate to severe zoster-associated pain that had not responded to standard medications were retrospectively reviewed. Read More

    A case study of Ramsay Hunt Syndrome in conjunction with cranial polyneuritis.
    Medicine (Baltimore) 2017 Nov;96(47):e8833
    Department of Neurology, Dongzhimen Hospital, The First Affiliated Hospital of Beijing University of Chinese Medicine, Beijing, China.
    Rationale: Ramsay Hunt syndrome in conjunction with cranial polyneuritis is not extensively documented, and is very easily misdiagnosed.

    Patient Concerns: A case of a 53-year-old male with Ramsay Hunt syndrome in conjunction with cranial polyneuritis is presented with early symptoms of vertigo, cephalalgia, and facial palsy, followed by zoster oticus 10 days later.

    Diagnoses: Diagnosis was challenging as this condition presents with multiple neuropathies, and attempting to diagnose based on clinical symptoms was often misleading. Read More

    Incidence of diseases primarily affecting the skin by age group: population-based epidemiologic study in Olmsted County, Minnesota, and comparison with age-specific incidence rates worldwide.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    Understanding the effects of age on the epidemiology of diseases primarily affecting the skin is important to the practice of dermatology, both for proper allocation of resources and for optimal patient-centered care. To fully appreciate the effect that age may have on the population-based calculations of incidence of diseases primarily affecting the skin in Olmsted County, Minnesota, and worldwide, we performed a review of all relevant Rochester Epidemiology Project-published data and compared them to similar reports in the worldwide English literature. Using the Rochester Epidemiology Project, population-based epidemiologic studies have been performed to estimate the incidence of specific skin diseases over the past 50 years. Read More

    Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation.
    J Infect Chemother 2018 Jan 16. Epub 2018 Jan 16.
    Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
    Disseminated fusariosis (DF) is a rare life threatening fungal infection in immunocompromised hosts. We herein report a case of a fatal DF mimicking varicella zoster virus (VZV) infection that was emerged from a localized genital infection during cord blood transplantation (CBT) in a patient with severe aplastic anemia (SAA). The patient developed an ulcer following small painful vesicles mimics herpes simplex virus infection (HSV) on the glans penis before CBT, but a Fusarium species was identified. Read More

    Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR.
    Invest Ophthalmol Vis Sci 2018 Jan;59(1):582-589
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States.
    Purpose: Infectious uveitis is a serious sight-threatening infection commonly caused by herpesviruses and Toxoplasma gondii. Etiologic diagnosis based on the clinical evaluation is often challenging. We developed and validated a multiplex real-time PCR assay coupled with high-resolution melting (HRM) for rapid detection and identification of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), and T. Read More

    Recommendations of the Advisory Committee on Immunization Practices for Use of Herpes Zoster Vaccines.
    MMWR Morb Mortal Wkly Rep 2018 Jan 26;67(3):103-108. Epub 2018 Jan 26.
    On October 20, 2017, Zoster Vaccine Recombinant, Adjuvanted (Shingrix, GlaxoSmithKline, [GSK] Research Triangle Park, North Carolina), a 2-dose, subunit vaccine containing recombinant glycoprotein E in combination with a novel adjuvant (AS01), was approved by the Food and Drug Administration for the prevention of herpes zoster in adults aged ≥50 years. The vaccine consists of 2 doses (0.5 mL each), administered intramuscularly, 2-6 months apart (1). Read More

    Unusual case of hemidiaphragmatic paralysis secondary to cervical herpes zoster.
    BMJ Case Rep 2018 Jan 23;2018. Epub 2018 Jan 23.
    Department of Respiratory Medicine, University Hospitals of North Midlands NHS Trust, Stoke on Trent, UK.
    Hemidiaphragmatic paralysis is usually caused by surgery, malignancy or trauma and rarely by viral infections. Herpes zoster (shingles) results in varied neurological complications, but peripheral motor involvement or diaphragmatic paralysis is rare. We report the case of an 87-year-old male who presented with worsening breathlessness soon after an episode of shingles, affecting his right neck and upper chest. Read More

    Modeling the impact of combined vaccination programs against varicella and herpes zoster in Norway.
    Vaccine 2018 Feb 20;36(8):1116-1125. Epub 2018 Jan 20.
    Department of Economics and Management, University of Pisa, Pisa, Italy. Electronic address:
    Background: Adoption of varicella immunization in Europe is limited due to a predicted increase in the incidence of herpes zoster (HZ) resulting from a removal of exogenous boosting by varicella vaccination. Most available assessments of immunization strategies only considered universal varicella vaccination (alone or in combination with HZ by the live vaccine). The development of a new subunit recombinant zoster vaccine may provide new perspectives of HZ control. Read More

    Lichen planus and lichenoid drug eruption after vaccination.
    Cutis 2017 Dec;100(6):E6-E20
    Harvard School of Public Health, Boston, Massachusetts, USA; and National Skin Centre, Singapore.
    Lichen planus (LP) and lichenoid drug eruptions (LDEs) uncommonly occur after vaccination, especially for hepatitis B and influenza. The key initiating event that leads to the development of postimmunization LP or LDE is not well understood. There have been prior reports of an association between several vaccines and LP. Read More

    Postherpetic Neuralgia and Trigeminal Neuralgia.
    Pain Res Treat 2017 5;2017:1681765. Epub 2017 Dec 5.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust management of pain during the early stage of acute herpes zoster. If it does occur, PHN may persist for months or even years after resolution of the HZ mucocutaneous eruptions, and treatment is often only partially effective. Read More

    Light-emitting diodes in dermatology: A systematic review of randomized controlled trials.
    Lasers Surg Med 2018 Jan 22. Epub 2018 Jan 22.
    Department of Dermatology, Downstate Medical Center, State University of New York, Brooklyn, New York.
    Objective: In dermatology, patient and physician adoption of light-emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic uses of LEDs in dermatology based on published efficacy and safety data.

    Methods: A systematic review of the published literature on the use of LED treatments for skin conditions was performed on September 13th 2017. Read More

    [Effect of joss stick moxibustion combined with pricking and cupping for acute herpes zoster and its mechanism of analgesia].
    Zhongguo Zhen Jiu 2017 Dec;37(12):1289-93
    Acupuncture and Moxibustion Department, the Second People's Hospital Affiliated to Fujian University of CM, Fuzhou 350003.
    Objective: To observe the effects of conventional western medication and joss stick moxibustion combined with pricking and cupping for herpes zoster in acute stage, and to explore its analgesic mechanism.

    Methods: Seventy patients with acute herpes zoster were randomized into an observation group (33 cases after 2 dropping) and a control group (34 cases after 1 dropping). Patients in the observation group were treated with joss stick moxibustion combined with pricking and cupping at localpoints for 7 times, once every other day. Read More

    MRI findings of postherpetic abdominal wall pseudohernia: A case report.
    Clin Imaging 2018 Jan 9;50:109-112. Epub 2018 Jan 9.
    Radiology Department, Clínica Dávila, Santiago, Chile.
    Herpes zoster is caused by the reactivation of latent varicella-zoster virus from dorsal root ganglia. Although infrequent, simultaneous damage to the anterior horn cells or anterior nerve roots at the same level may result in motor neuropathy. When motor involvement is localized in the abdominal wall, a pseudohernia may be the clinical presentation. Read More

    Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
    J Neuroinflammation 2018 Jan 17;15(1):20. Epub 2018 Jan 17.
    TWINCORE Centre for Experimental and Clinical Infection Research GmbH, Feodor-Lynen-Str. 7, 30625, Hannover, Germany.
    Background: Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. Read More

    Postherpetic abdominal pseudohernia: A diagnostic pitfall.
    J Gen Fam Med 2018 Jan 11;19(1):36-37. Epub 2017 Dec 11.
    Department of General Internal MedicineIizuka HospitalFukuokaJapan.
    The accurate diagnosis of postherpetic abdominal pseudohernia, the rare complication of herpes zoster, is essential to avoid unnecessary imaging studies or surgery. Close observation and waiting for complete recovery are warranted considering the disease's self-resolving nature and favorable prognosis. Read More

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