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    1 OF 317

    Adjuvant strategies to improve vaccination of the elderly population.
    Curr Opin Pharmacol 2018 Apr 17;41:34-41. Epub 2018 Apr 17.
    Institute for Biomedical Aging Research, Universität Innsbruck, Innsbruck, Austria. Electronic address:
    Immunosenescence contributes to increased incidence and severity of many infections in old age and is responsible for impaired immunogenicity and efficacy of vaccines. Adjuvants are one strategy to enhance immunogenicity of vaccines. The oil-in-water emulsions MF59TM and AS03, as well as a virosomal vaccine have been licensed in seasonal or pandemic influenza vaccines and are/were used successfully in the elderly. Read More

    [Extra-facial Lever granuloma on a herpes zoster scar: Wolf's isotopic response].
    Ann Dermatol Venereol 2018 Apr 16. Epub 2018 Apr 16.
    Service de dermatologie, CHR Metz-Thionville, 1, allée du Château, 57245 Ars-Laquenexy, France.
    Background: Granuloma faciale (GF), or facial granuloma of Lever, is an uncommon dermatosis occurring classically on the face. We report a case of a GF on zoster scars located on the trunk, which is a highly particular isotopic response.

    Patients And Methods: A 60-year-old man with a sole history of left lumbar zoster presented with a skin lesion present for two months. Read More

    Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis.
    Inflamm Bowel Dis 2018 Apr 13. Epub 2018 Apr 13.
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
    Background: Little is known about the prevalence and pathogenicity of human herpes viruses except for cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of human herpes viruses on colonic mucosa in patients with IBD and assess the long-term outcomes in these patients.

    Methods: We examined the colonic mucosal specimens from 66 patients with ulcerative colitis (UC), 54 patients with Crohn's disease (CD), and 29 healthy patients to identify the 6 most common types of human herpes virus, using multiplex polymerase chain reaction (PCR) technique. Read More

    The Skin and the Eye - Herpes Zoster Ophthalmicus in a Healthy 18-month-old Toddler.
    Folia Med (Plovdiv) 2018 Mar;60(1):170-174
    Department of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria.
    Herpes zoster, caused by reactivation of varicella-zoster virus, is uncommon in infancy. Even more uncommon is herpes zoster ophthalmicus, defined as herpes zoster of the ophthalmic branch of the fifth cranial nerve. Among healthy children, primary varicella-zoster virus infection during gestation as a result of maternal varicella or the first year of life is the major risk factor for development of herpes zoster in a relatively young age. Read More

    Longitudinal analysis of varicella-zoster virus-specific antibodies in systemic lupus erythematosus: No association with subclinical viral reactivations or lupus disease activity.
    Lupus 2018 Jan 1:961203318770535. Epub 2018 Jan 1.
    1 Department of Rheumatology and Clinical Immunology, 10173 University Medical Centre Groningen , University of Groningen, The Netherlands.
    Systemic lupus erythematosus (SLE) patients are at high risk of herpes zoster. Previously, we found increased immunoglobulin (Ig)G levels against varicella-zoster virus (VZV) in SLE patients compared to controls, while antibody levels against diphtheria and cellular immunity to VZV were decreased. We aimed to test our hypothesis that increased VZV-IgG levels in SLE result from subclinical VZV reactivations, caused by stress because of lupus disease activity or immunosuppressive drug use. Read More

    No increased risk of herpes zoster in TNF inhibitor and non-TNF inhibitor users with rheumatoid arthritis: epidemiological study using the Japanese health insurance database.
    Int J Rheum Dis 2018 Apr 17. Epub 2018 Apr 17.
    Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
    Objective: It is controversial whether the use of biological disease-modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non-TNFI users with rheumatoid arthritis (RA) over 3 years in Japan.

    Method: Using the Japanese health insurance database, we assigned patients with at least one RA diagnostic code and one prescription for any DMARDs (RA cases) recorded between January 2005 and December 2013 to the RA group. Read More

    Zika Virus IgG in Infants with Microcephaly, Guinea-Bissau, 2016.
    Emerg Infect Dis 2018 May;24(5):948-950
    We analyzed blood samples from infants born with microcephaly and their mothers in Guinea-Bissau in 2016 for pathogens associated with birth defects. No Zika virus RNA was detected, but Zika virus IgG was highly prevalent. We recommend implementing pathogen screening of infants with congenital defects in Guinea-Bissau. Read More

    Low Rates of Vaccination for Herpes Zoster in Older People Living with HIV.
    AIDS Res Hum Retroviruses 2018 Apr 17. Epub 2018 Apr 17.
    University of Colorado, Aurora, Colorado, United States ;
    Background: Herpes zoster (HZ) occurs at a higher age-specific rate in people living with HIV (PLWH) than in the general population. We implemented a quality improvement study to assess herpes zoster vaccine (HZV) usage among PLWH, assess HZV usage after additional reminders/prompts, and identify barriers to HZV among older PLWH.

    Methods: HZV rates in PLWH were determined in six institutions with varying payment structures. Read More

    Real World Evidence for Regulatory Decisions: Concomitant Administration of Zoster Vaccine Live and Pneumococcal Polysaccharide Vaccine.
    Am J Epidemiol 2018 Apr 11. Epub 2018 Apr 11.
    Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California.
    The US Food and Drug Administration is charged with expanding the use of real world evidence (RWE) for regulatory decisions. As a test case for RWE to support regulatory decisions, we present the scenario of concomitant vaccination with zoster vaccine live (ZVL) and 23-valent pneumococcal polysaccharide vaccine (PPSV23). The prescribing information states that these vaccines should not be given concurrently, based on a small trial using varicella zoster virus antibody levels as a correlate of ZVL efficacy, even though ZVL protects against herpes zoster via cell-mediated immunity. Read More

    Varicella Zoster Virus Reactivation in Adult Survivors of Hematopoietic Cell Transplantation: How Do We Best Protect Our Patients?
    Biol Blood Marrow Transplant 2018 Apr 10. Epub 2018 Apr 10.
    Department of Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
    Reactivation of varicella zoster virus (VZV) remains a significant public health burden for long-term survivors of hematopoietic cell transplantation. Delayed immune reconstitution after transplantation due to immunosuppression, posttransplant therapies, poor engraftment, and graft-versus-host disease leave a large number of patients at risk for herpes zoster (shingles) and its highly morbid complications. Although prophylaxis with acyclovir or valacyclovir has reduced the incidence of VZV reactivation as long as prophylaxis is continued, the incidence of disease in the late posttransplant period or after stopping prophylaxis is greater in the HCT population than the general public. Read More

    Safety and Efficacy of Different Systemic Treatment Modalities for Acute Pain of Herpes Zoster: A Pilot Study.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):101-104
    Department of Dermatology, AVBRH, JNMC, DMIMS, Wardha (Meghe), Maharashtra, India.
    Background: Herpes zoster is a viral infection of skin caused by Varicella Zoster virus. The most important symptom for which the patient seeks medical advice is pain, which is perceived before the development of rash and lasts even after its resolution. The pain during the first 30 days after onset of herpes zoster is known as acute herpetic neuralgia. Read More

    Clinico-epidemiological study of morphea from a tertiary care hospital.
    Curr Rheumatol Rev 2018 Apr 9. Epub 2018 Apr 9.
    Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University (AMU), Aligarh. India.
    Introduction: Morphea is an uncommon disease that presents with skin induration and sclerosis. The disease is common in Caucasians and there are few studies describing the clinico-epidemiological profile of these patients from the Indian subcontinent.

    Methods: This prospective study was conducted during a three year period from June 2014 to May 2017. Read More

    Herpes Zoster Ophthalmicus With Orbital Findings Preceding Skin Rash.
    Ophthal Plast Reconstr Surg 2018 Apr 3. Epub 2018 Apr 3.
    Southside Eye Care, Chesapeake, Virginia.
    The authors describe 2 patients who presented with orbital findings and later developed vesicular lesions that were positive for varicella zoster virus and consistent with Herpes Zoster ophthalmicus. One case is the first to involve dacryoadenitis and orbital myositis preceding disseminated Herpes Zoster. In the other case, a patient developed zoster orbital syndrome leading to elevated intraocular pressure, loss of vision, and afferent pupillary defect. Read More

    Granulysin as a novel factor for the prognosis of the clinical course of chickenpox.
    Epidemiol Infect 2018 Apr 10:1-4. Epub 2018 Apr 10.
    Burch University Sarajevo,Bosnia-Herzegovina.
    Granulysin is a recently discovered cytolytic protein of natural killer (NK) cells and cytotoxic T lymphocytes. Studies of healthy and immunocompromised patients with primary or recurrent varicella-zoster infections demonstrate the importance of virus-specific cellular immunity in controlling viral replication, but also some studies presented granulysin as a molecule that can play a role in chickenpox immunopathogenesis. This study investigated possible correlation between serum granulysin levels and clinical course of chickenpox. Read More

    Treatment of herpes zoster ophthalmicus: a systematic review and Canadian cost-comparison.
    Can J Ophthalmol 2018 Apr 10;53(2):117-123. Epub 2017 Oct 10.
    Schulich School of Medicine & Dentistry, Western University, London, Ont; Ivey Eye Institute, St. Joseph's Health Care London, London, Ont.. Electronic address:
    Objective: A systematic review and cost comparison were conducted to determine the optimal treatment of active herpes zoster ophthalmicus (HZO) in immunocompetent adults.

    Design: A literature search of MEDLINE, EMBASE, CINAHL, Cochrane Library, BIOSIS Previews and Web of Science,, International Clinical Trials Registry Platform, Networked Digital Library of Theses and Dissertations, and Canadian Health Research Collection was performed. Read More

    Classic paper: Are the chickenpox virus and the zoster virus identical?: HELMUT RUSKA.
    Rev Med Virol 2018 Apr 6:e1975. Epub 2018 Apr 6.
    Institute of Virology, University of Ulm Medical School, Ulm, Germany.
    As early as 1943, the German physician Helmut Ruska visualized the virus of varicella and zoster (at that time, he was not completely certain whether the virus was the same) by the newly developed electron microscope; he is regarded as the discoverer of this virus. Here, we present a translation of his classical paper into the English language. In our introduction and commentary to his paper, we discuss the significance of Helmut Ruska's work for the development of virology, his distinction between the varicella, zoster, and herpes virus group on one hand and poxviruses on the other, as well as the development of imaging techniques which have refined or substituted for electron microscopy of viruses and virus-infected cells. Read More

    Secular Trends in Infection-Related Mortality after Kidney Transplantation.
    Clin J Am Soc Nephrol 2018 Apr 5. Epub 2018 Apr 5.
    Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; and
    Background And Objectives: Infections are the most common noncardiovascular causes of death after kidney transplantation. We analyzed the current infection-related mortality among kidney transplant recipients in a nationwide cohort in Finland.

    Design, Setting, Participants, & Measurements: Altogether, 3249 adult recipients of a first kidney transplant from 1990 to 2012 were included. Read More

    The Risk of Herpes Zoster in Patients with Non-small Cell Lung Cancer according to Chemotherapy Regimens: Tyrosine Kinase Inhibitors versus Cytotoxic Chemotherapy.
    Cancer Res Treat 2018 Apr 5. Epub 2018 Apr 5.
    Department of Dermatology, Seoul National University Hospital, Seoul, Korea.
    Purpose: Despite the successful use of tyrosine kinase inhibitors (TKIs) in cancer patients, their effect on herpes zoster development has not been studied. The aim of this study was to evaluate and compare the effects of epidermal growth factor receptor (EGFR) TKI and cytotoxic chemotherapy on the risk of herpes zoster development in non-small cell lung cancer (NSCLC) patients.

    Materials And Methods: We conducted a medical review of all eligible NSCLC patients in Seoul National University hospital between 2002 and 2015. Read More

    Maritime varicella illness and death reporting, U.S., 2010-2015.
    Travel Med Infect Dis 2018 Apr 2. Epub 2018 Apr 2.
    DGMQ, CDC, 1600 Clifton Road NE, Atlanta, GA 30329-4018, United States. Electronic address:
    Background: Ships destined for, or departing from, U.S. ports of entry must report certain signs and symptoms of potentially communicable diseases of public health interest among travelers to the Division of Global Migration and Quarantine (DGMQ) at the Centers for Disease Control and Prevention. Read More

    Biological treatment for psoriasis and the risk of herpes zoster: Results from the Psoriasis Longitudinal Assessment and Registry (PSOLAR).
    J Dermatolog Treat 2018 Apr 5:1-20. Epub 2018 Apr 5.
    h Siaal Research Center for Family Medicine and Primary Care , Faculty of Health Sciences; Ben-Gurion University of the Negev , Beer Sheva , Israel.
    Purpose: To describe the risk of herpes zoster (HZ) in patients with psoriasis and its relation to non-biologic systemic therapies or biologic treatment.

    Materials And Methods: Psoriasis Longitudinal Assessment and Registry (PSOLAR) is an international, prospective, registry that follows adult patients with psoriasis eligible to receive non-biologic systemic therapies or biologic therapies. Mutually exclusive therapy cohorts were defined. Read More

    The public health value of vaccination for seniors in Europe.
    Vaccine 2018 Mar 31. Epub 2018 Mar 31.
    Spanish Society of Geriatrics and Gerontology President, Committee Member Vaccines of SEGG, Malaga, Spain. Electronic address:
    Longer life expectancy and decreasing fertility rates mean that the proportion of older people is continually increasing worldwide, and particularly in Europe. Ageing is associated with an increase in the risk and severity of infectious diseases. These diseases are also more difficult to diagnose and manage in seniors who often have at least one comorbid condition (60% of seniors have two or more conditions). Read More

    [Rapidly deteriorated lobar intracerebral hemorrhages: possible association of varicella zoster virus-vasculopathy].
    Rinsho Shinkeigaku 2018 Mar 31. Epub 2018 Mar 31.
    Department of Neurology, Brain Attack Center, Ota Memorial Hospital.
    A 75-year-old man having dementia and lifestyle related diseases developed a lobar intracerebral hemorrhage (LICH) in the left parietal and a small cerebellar infarction in the left occipital lobe. Many micro bleeds (MB) due to cerebral amyloid angiopathy (CAA) in the subcortical areas and multiple vascular stenosis were also found by MRI and MRA. He developed herpes zoster in his buttocks on day 6 of hospitalization and complicated with varicella zoster virus (VZV) meningitis with positive for VZV-DNA in the cerebrospinal fluid. Read More

    Herpes zoster-induced acute urinary retention: Two cases and literature review.
    Niger J Clin Pract 2018 Apr;21(4):534-537
    Department of Urology, Jinling Hospital, Nanjing, China.
    We report two uncommon cases of acute urinary retention in Chinese patients caused by reactivation of sacral herpes zoster and requiring bladder drainage. Indwelling urinary catheterization, antiviral medication (ganciclovir), and physiotherapy with infrared light (830 nm) led to successful recovery of the micturition reflex in both cases. Read More

    Usefulness of Inflammatory Markers for the Prediction of Postherpetic Neuralgia in Patients with Acute Herpes Zoster.
    Ann Dermatol 2018 Apr 21;30(2):158-163. Epub 2018 Feb 21.
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.
    Background: Increasing evidence suggests a pivotal role for neuronal inflammation in response to replicating varicella zoster virus in the development of postherpetic neuralgia (PHN).

    Objective: In this study, we investigated the value of serum levels of various inflammatory markers in acute herpes zoster (HZ) as predictors for the development of PHN.

    Methods: A total of 116 patients with acute HZ were enrolled in this study. Read More

    Viral load and antibody boosting following herpes zoster diagnosis.
    J Clin Virol 2018 Mar 21;103:12-15. Epub 2018 Mar 21.
    Division of Infection & Immunity, University College London, London, UK.
    Background: Acute varicella zoster virus (VZV) replication in shingles is accompanied by VZV antibody boosting. It is unclear whether persisting virus shedding affects antibody levels.

    Objectives: To investigate the relationship between VZV viral load and antibody titres in shingles patients during six months following diagnosis and assess whether VZV antibody titre could discriminate patients with recent shingles from healthy population controls. Read More

    Risk of Anterior Segment Complications Associated With the Live Herpes Zoster Vaccine: Evidence From a Health-Claim Database.
    Cornea 2018 Mar 28. Epub 2018 Mar 28.
    Department of Ophthalmology and Visual Sciences, The University of British Columbia, Vancouver, Canada.
    Purpose: To determine the risk of developing anterior segment complications after receiving the live herpes zoster virus vaccine.

    Methods: This retrospective cohort study included a random sample of 9 million patients registered in a health-claim database in the United States between 2006 and 2016. Herpes zoster-related anterior segment diseases were identified by International Classification of Diseases ninth or tenth edition codes (an event). Read More

    Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome.
    Front Immunol 2018 23;9:237. Epub 2018 Feb 23.
    Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
    The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. Read More

    Corneal Innervation and Sensation: The Eye and Beyond.
    Yale J Biol Med 2018 Mar 28;91(1):13-21. Epub 2018 Mar 28.
    Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT.
    The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors - all of which combined help to maintain the structural and functional integrity of the surface of the eye. Consequently, damage to corneal nerves as a result of disease, surgery, or trauma can lead to diminished corneal sensitivity, epithelial defects, and possible blindness. Read More

    Herpes Zoster in Persons Living with HIV-1 Infection: Viremia and Immunological Defects Are Strong Risk Factors in the Era of Combination Antiretroviral Therapy.
    Front Public Health 2018 12;6:70. Epub 2018 Mar 12.
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
    In a cohort of 4,225 persons living with human immunodeficiency virus type 1 (HIV-1) infection (PLWH) enrolled at a southeastern US clinic, the overall rate of incident herpes zoster (HZ) was 101 per 10,000 person-years (PY) between January 1999 and 2017, which nearly quadruples the rate reported for the general US population. In the same cohort, the median age of HZ diagnosis was 39.5 years [interquartile range (IQR) 31. Read More

    Safety and Immunogenicity of Zoster Vaccine Live in HIV-Infected Adults with CD4+ Cell Counts Above 200 Cells/mL Virologically Suppressed on Antiretroviral Therapy.
    Clin Infect Dis 2018 Mar 26. Epub 2018 Mar 26.
    Division of Infectious Diseases, Emory University, Atlanta, GA.
    Background: Herpes zoster (HZ) risk is increased in HIV-infected persons. Live attenuated zoster vaccine (ZV) reduces HZ incidence and severity in older adults; ZV safety and immunogenicity data in HIV-infected adults are limited.

    Methods: We conducted a randomized, double-blind, placebo-controlled trial in HIV-infected adults virologically suppressed on antiretroviral therapy (ART). Read More

    Post-licensure safety surveillance of zoster vaccine live (Zostavax®) in the United States, Vaccine Adverse Event Reporting System (VAERS), 2006-2015.
    Hum Vaccin Immunother 2018 Mar 26:1-23. Epub 2018 Mar 26.
    a Immunization Safety Office, Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases , Centers for Disease Control and Prevention , United States.
    Background: Herpes zoster (HZ), or shingles, is caused by reactivation of varicella-zoster virus in latently infected individuals. Live-attenuated HZ vaccine (zoster vaccine live, ZVL) is approved in the United States for persons aged ≥50 years and recommended by the CDC for persons ≥60 years.

    Methods: We analyzed U. Read More

    Evaluating Physician Attitudes and Practices Regarding Herpes Zoster Vaccination.
    Cornea 2018 Mar 23. Epub 2018 Mar 23.
    Department of Ophthalmology, New York University School of Medicine, New York, New York.
    Purpose: To investigate the knowledge, attitudes, and practice patterns of primary care physicians regarding administration of the herpes zoster (HZ) vaccine at NYU Langone Health (NYULH).

    Methods: A cross-sectional online survey was distributed from January to March 2017 to all physicians in the Division of General Internal Medicine and Clinical Innovation at NYULH across 5 different practice settings.

    Results: The response rate was 26% (138 of 530). Read More

    Herpes zoster, active component, U.S. Armed Forces, 2000-2016.
    MSMR 2018 Mar;25(3):19-27
    During 2000-2016, a total of 52,895 active component service members received incident diagnoses of herpes zoster (HZ), for an overall unadjusted incidence rate of 2.5 cases per 1,000 person-years (p-yrs). Compared to their respective counterparts, overall incidence rates of HZ were highest among females, those aged 50 years or older, and Air Force members. Read More

    Orbital Apex Syndrome Secondary to Herpes Zoster Ophthalmicus.
    Turk J Ophthalmol 2018 Feb 23;48(1):42-46. Epub 2018 Feb 23.
    Dokuz Eylul University Faculty of Medicine, Department of Radiology, İzmir, Turkey.
    Orbital apex syndrome is a rare complication of herpes zoster ophthalmicus. A patient being followed in our clinic for herpes zoster ophthalmicus developed orbital apex syndrome in the second week of treatment. Clinical diagnosis was supported by magnetic resonance imaging. Read More

    Herpes zoster ophthalmicus evolving into headache characterised as hemicrania continua.
    BMJ Case Rep 2018 Mar 23;2018. Epub 2018 Mar 23.
    Department of Neurolgy, Smt BK Shah Medical Institute and Research Centre, Vadodara, India.
    Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster infection. However, a few patients may develop different types of pain after herpetic lesions. We are reporting two patients who developed postherpetic hemicrania continua (HC). Read More

    Small Vessel Vasculitis in Herpes Zoster-Discussion of Current Aspects of Varicella Zoster Virus Vasculopathy.
    Am J Dermatopathol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Dermatology, Saarland University Medical Center, Homburg/Saar, Germany.
    Varicella zoster virus (VZV) vasculopathy was initially described as herpes zoster ophthalmicus with contralateral hemiplegia in 1896. VZV is able to infect endothelial cells directly, leading to a thickened intima and vascular remodeling due to inflammation. Therefore, a spectrum of vasculopathies is induced, ranging from a discrete capillaritis-to-granulomatous vasculitis and obliterative angiitis. Read More

    [Encephalitis as a complication of Herpes Zoster ophtalmicus].
    J Fr Ophtalmol 2018 Mar 19;41(3):e95-e97. Epub 2018 Mar 19.
    Service de réanimation médicale, hôpital militaire d'instruction, Mohammed-V-de-Rabat, Maroc; Faculté de médecine et de pharmacie de Rabat, université Mohammed-V-Souissi, avenue Mohammed-Belarabi-Elalaoui, BP6203 Rabat-Instituts, Rabat, Maroc.

    Cutaneous infections in the mature patient.
    Clin Dermatol 2018 Mar - Apr;36(2):188-196. Epub 2017 Oct 3.
    Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    Dermatologists must be familiar with the peculiarities of the micro-organisms that may affect the elderly, in order to optimize the diagnosis and treatment of infections, which may affect their skin, especially because the world population is rapidly aging. It is estimated that there will be 434 million individuals over 80 years of age in 2050. Since the elderly population is rapidly increasing and their infections are usually more severe and different from those observed in younger adults, it leads to a statistical increase of the rates regarding hospitalization and mortality caused by infectious diseases among people over 85 years. Read More

    Rapid Viral Diagnosis of Orthopoxviruses by Electron Microscopy: Optional or a Must?
    Viruses 2018 03 22;10(4). Epub 2018 Mar 22.
    (ret) University of Newcastle upon Tyne, Burnfoot, Stocksfield, Northumberland, NE43 7TN, UK.
    Diagnostic electron microscopy (DEM) was an essential component of viral diagnosis until the development of highly sensitive nucleic acid amplification techniques (NAT). The simple negative staining technique of DEM was applied widely to smallpox diagnosis until the world-wide eradication of the human-specific pathogen in 1980. Since then, the threat of smallpox re-emerging through laboratory escape, molecular manipulation, synthetic biology or bioterrorism has not totally disappeared and would be a major problem in an unvaccinated population. Read More

    Management of herpes zoster (shingles) during pregnancy.
    J Obstet Gynaecol 2018 Mar 22:1-8. Epub 2018 Mar 22.
    a Medical College of Georgia , Augusta University , Augusta , GA , USA.
    An infection with the varicella-zoster virus (VZV) causes both varicella and herpes zoster (HZ). Although rare, the development of HZ does occur during pregnancy. Maternal HZ does not result in increased foetal mortality, and the passage of VZV to the foetus rarely occurs. Read More

    Detection of the incidence of infections and acute biochemical changes in Diffuses Large B-Cell Lymphoma patients treated with Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) with and without Rituximab.
    Curr Drug Saf 2018 03 20. Epub 2018 Mar 20.
    National Institute of Blood Diseases and Bone marrow Transplantation Karachi, Pakistan
    Aim And Objectives: Acute biochemical changes, hepatotoxicity, nephrotoxicity and frequency of infections are common in diffuse large B-cell Lymphoma patients undergoing Cyclophosphamide, hydroxyrubicin, Oncovin (Vincristine) Prednisolone (CHOP) and Rituximab plus CHOP chemo cycles. Eventually, it leads to prolong hospital stay and suspending the next chemotherapy cycles. Changes in biochemical profile and immunosuppressant effects correlated with dose intensity ratio, the findings of this study will be helpful in choices for the physician to discontinue therapy or delaying treatment. Read More

    Age-associated differences in infection of human skin in the SCID mouse model of varicella-zoster virus pathogenesis.
    J Virol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Pediatrics; Stanford University School of Medicine, Stanford, CA.
    Varicella-zoster virus (VZV) is the skin-tropic human alphaherpesvirus responsible for both varicella and herpes zoster. Varicella and herpes zoster skin lesions have similar morphology but herpes zoster occurs disproportionally in older individuals and is often associated with a more extensive local rash and severe zoster-related neuralgia. We hypothesized that skin aging could also influence the outcome of the anterograde axonal transport of VZV to skin. Read More

    [The efficacy of ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment for aged lower back post-herpetic neuralgia].
    Zhonghua Yi Xue Za Zhi 2018 Mar;98(10):733-737
    Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
    To evaluate the efficacy of ultrasound-guided spinal nerve posterior ramus pulsed radiofrequency treatment of lower back post-herpetic neuralgia. One hundred and twenty-eight cases of lower back or anterior abdominal wall acute post-herpetic neuralgia patients were enrolled. They were randomly divided into two groups. Read More

    [Topical ozone therapy: An innovative solution to patients with herpes zoster].
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Feb;43(2):168-172
    Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
    Objective: To observe the clinical efficacy and safety of topical ozone therapy for patients with herpes zoster by reflectance confocal microscopy (RCM).
 Methods: A total of 60 patients with herpes zoster were divided into a control group and an ozone treatment group (n=30). In the control group, patients took oral valacyclovir tablets or granules (0. Read More

    Effectiveness of herpes zoster vaccination in an older United Kingdom population.
    Vaccine 2018 04 17;36(17):2371-2377. Epub 2018 Mar 17.
    Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
    Background: Vaccination against herpes zoster was introduced in the United Kingdom in 2013 for individuals aged 70 years, with a phased catch-up campaign for 71-79 year olds. Vaccine introduction has resulted in a marked fall in incident herpes zoster and in post-herpetic neuralgia (PHN), but formal evaluation of vaccine effectiveness is needed.

    Methods: In a population-based cohort study of older individuals born between 1933 and 1946, we used linked UK anonymised primary care health records for the first three years of the vaccination programme (01/09/2013-31/08/2016) and multivariable Poisson regression to obtain incidence rates and vaccine effectiveness (VE) against zoster and PHN. Read More

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