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    Receipt of other routinely recommended vaccines relative to receipt of seasonal influenza vaccines: Trends from medicare administrative data, 2013-2015.
    Vaccine 2018 Jun 13. Epub 2018 Jun 13.
    Center for Medicare, Centers for Medicare & Medicaid Services, Baltimore, MD, United States.
    Annual influenza vaccination campaigns emphasize the importance of getting vaccinated against influenza. These campaigns offer potential opportunities to raise awareness of all vaccines. We explored the peak timing of the receipt of influenza and other routinely recommended vaccinations. Read More

    Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial.
    Lancet 2018 Jun 12. Epub 2018 Jun 12.
    AbbVie Inc, North Chicago, IL, USA.
    Background: Phase 2 studies with upadacitinib, a selective Janus kinase 1 (JAK1) inhibitor, have shown safety and efficacy in the treatment of patients with active rheumatoid arthritis. We did this study to further assess the safety and efficacy of upadacitinib in patients with an inadequate response to biologic disease-modifying anti-rheumatic drugs (bDMARDs).

    Methods: We did this double-blind, randomised controlled phase 3 trial at 153 sites in 26 countries. Read More

    Safety and efficacy of upadacitinib in patients with rheumatoid arthritis and inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (SELECT-NEXT): a randomised, double-blind, placebo-controlled phase 3 trial.
    Lancet 2018 Jun 12. Epub 2018 Jun 12.
    AbbVie Inc, North Chicago, IL, USA.
    Background: Upadacitinib is a selective inhibitor of Janus kinase 1 and was efficacious in phase 2 studies in patients with moderate-to-severe rheumatoid arthritis. We aimed to assess the efficacy of upadacitinib in patients with inadequate response to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).

    Methods: This study is a double-blind, placebo-controlled trial at 150 sites in 35 countries. Read More

    Improving herpes zoster vaccine rates: The impact of a targeted educational program.
    J Am Assoc Nurse Pract 2018 Jun 4. Epub 2018 Jun 4.
    South Nassau Communities Hospital, Oceanside, New York.
    Background And Purpose: Despite demonstrated efficacy, the utilization of herpes zoster vaccine (HZV), recommended by the Centers for Disease Control (CDC) for all immunocompetent adults aged above 60 years, is low (31%). The aim of this study was to identify nurse practitioner (NP) barriers to HZV administration and then to use these results to develop and evaluate the outcomes of an educational program.

    Methods: This study used a two-phase design. Read More

    Immunogenicity and safety of the adjuvanted recombinant zoster vaccine co-administered with the 23-valent pneumococcal polysaccharide vaccine in adults ≥50 years of age: A randomized trial.
    Vaccine 2018 Jun 11. Epub 2018 Jun 11.
    GSK, Wavre, Belgium. Electronic address:
    Background: This study evaluated immunogenicity and safety of the adjuvanted recombinant zoster vaccine (RZV) when the first dose was co-administered with the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in adults aged ≥50 years.

    Methods: In this open label, multi-center study (NCT02045836), participants were randomized 1:1 to receive either the first dose of RZV and PPSV23, co-administered at Day 0 and the second dose of RZV at Month 2 (Co-Ad group), or PPSV23 at Day 0, the first dose of RZV at Month 2 and second dose of RZV at Month 4 (Control group). Co-primary objectives were the RZV vaccine response rate (VRR) in the Co-Ad group and the non-inferiority of the antibody responses to RZV and PPSV23 in the Co-Ad group compared to the Control group. Read More

    Analytical validation of viral CNS Flow Chip kit for detection of acute meningitis and encephalitis.
    J Virol Methods 2018 Jun 11. Epub 2018 Jun 11.
    Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria de Granada, Avda. Fuerzas Armadas, 2, Granada, 18014, Spain.
    A new molecular assay (Viral CNS Flow Chip kit, Master Diagnóstica, Spain) has been developed for the detection of eight viruses causing acute meningitis and encephalitis, i.e. herpes simplex viruses 1-2, varicella zoster virus, human enterovirus, human parechovirus, Toscana virus, human cytomegalovirus and Epstein Barr virus. Read More

    Statins increase the risk of herpes zoster: A propensity score-matched analysis.
    PLoS One 2018 14;13(6):e0198263. Epub 2018 Jun 14.
    Departments of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    Objectives: Statins, which are lipid-lowering agents, have anti-inflammatory and immunomodulatory properties that may affect the occurrence of various infectious diseases. We assessed whether statins increase the risk of herpes zoster (HZ) with propensity score-matching.

    Methods: The study was based on the National Health Insurance database and its subset database of the "medical check-up" population of South Korea. Read More

    Varicella-zoster virus and urologic practice: a case-based review.
    Can J Urol 2018 Jun;25(3):9301-9306
    Department of Urology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA.
    Introduction: Each year, varicella-zoster virus (VZV) affects nearly one million people in the United States, often in the form of herpes zoster, or shingles. The urologic system is a rare but often debilitating target. This paper reviews the epidemiology, symptomatology, diagnosis, and management of VZV as it relates to urologic practice. Read More

    Vaccine Development for Varicella-Zoster Virus.
    Adv Exp Med Biol 2018 ;1045:123-142
    Division of Clinical Virology, Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
    Varicella-zoster virus (VZV) is the first and only human herpesvirus for which a licensed live attenuated vaccine, vOka, has been developed. vOka has highly safe and effective profiles; however, worldwide herd immunity against VZV has not yet been established and it is far from eradication. Despite the successful reduction in the burden of VZV-related illness by the introduction of the vaccine, some concerns about vOka critically prevent worldwide acceptance and establishment of herd immunity, and difficulties in addressing these criticisms often relate to its ill-defined mechanism of attenuation. Read More

    Antiviral Drugs Against Alphaherpesvirus.
    Adv Exp Med Biol 2018 ;1045:103-122
    Department of Virology, University of Toyama, Toyama, Japan.
    The discovery of acyclovir and penciclovir has led to the development of a successful systemic therapy for treating herpes simplex virus infection and varicella-zoster virus infection, and the orally available prodrugs, valacyclovir and famciclovir, have improved antiviral treatment compliance. Acyclovir and penciclovir are phosphorylated by viral thymidine kinase and are incorporated into the DNA chain by viral DNA polymerase, resulting in chain termination. Helicase-primase plays an initial step in DNA synthesis to separate the double strand into two single strands (replication fork) and is a new target of antiviral therapy. Read More

    Neurological Disorders Associated with Human Alphaherpesviruses.
    Adv Exp Med Biol 2018 ;1045:85-102
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic fatal encephalitis worldwide, and central nervous system (CNS) involvement is observed in approximately one-third of neonatal HSV infections . In recent years, single-gene inborn errors of innate immunity have been shown to be associated with susceptibility to HSV encephalitis . Temporal lobe abnormalities revealed by magnetic resonance imaging-the most sensitive imaging method for HSV encephalitis-are considered strong evidence for the disease. Read More

    Herpes zoster with cutaneous dissemination: a rare presentation of an uncommon pathology in children.
    BMJ Case Rep 2018 Jun 12;2018. Epub 2018 Jun 12.
    Department of Pediatrics, Hospital de Braga, Braga, Portugal.
    Herpes zoster, caused by varicella zoster virus (VZV) reactivation, affects mainly the adult population, although it can occur in children. This happens when primary infection (varicella) has occurred at a very young age or in immunocompromised patients. Complications are rare in healthy individuals. Read More

    Discoid lupus erythematosus following herpes zoster.
    Cutis 2018 May;101(5):370-372
    Division of Dermatology, Cooper Medical School, Rowan University, Camden, New Jersey, USA.
    The isomorphic response is the appearance of new lesions from a preexisting skin condition at a site of trauma. Discoid lupus erythematosus (DLE) may develop on traumatized skin and also may arise at sites of a prior cutaneous eruption. We report the case of a 20-year-old woman with a history of systemic lupus erythematosus (SLE) and DLE who developed a painful, multidermatomal, vesicular rash on the left breast and back consistent with herpes zoster (HZ) during treatment with systemic immunosuppression. Read More

    Lupus and vaccinations.
    Curr Opin Rheumatol 2018 Jun 9. Epub 2018 Jun 9.
    Department of Internal Medicine 2, French National Reference Center for Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome, Institut E3M, Groupement Hospitalier Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris (AP-HP).
    Purpose Of Review: To review the latest data in the field of vaccinations in systemic lupus erythematosus (SLE), focusing on pneumococcal, seasonal influenza, herpes zoster and human papillomavirus infections.

    Recent Findings: Less than 40% of patients responded adequately to the 23-valent pneumococcal polysaccharide (PPS23) vaccine. A randomized controlled trial showed that sequential administration of the pneumococcal conjugate vaccine followed by the PPS23 vaccine was well tolerated but was not superior to the PPS23 vaccine alone in terms of immunogenicity. Read More

    Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link.
    J Alzheimers Dis 2018 Jun 4. Epub 2018 Jun 4.
    Division of Infection and Pathway Medicine, University of Edinburgh, Little France, Edinburgh, UK.
    Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potential treatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al. Read More

    Acyclovir-induced thrombocytopaenia in a patient with SLE.
    BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.
    Rheumatology, Nicosia General Hospital, Nicosia, Cyprus.
    Acyclovir has been used in the treatment of herpes simplex and varicella zoster viral infections for over 30 years. The side effects of oral treatment at standard doses are rare and include headache, diarrhoea, dizziness and malaise. We report a patient with a new diagnosis of systemic lupus erythematosus (SLE) who developed thrombocytopaenia within days on a therapeutic dose with acyclovir. Read More

    Burden of herpes zoster in 16 selected immunocompromised populations in England: a cohort study in the Clinical Practice Research Datalink 2000-2012.
    BMJ Open 2018 Jun 7;8(6):e020528. Epub 2018 Jun 7.
    GSK, Rockville, Maryland, USA.
    Objectives: Herpes zoster (HZ) is caused by reactivation of varicella-zoster virus which remains latent in individuals after a varicella infection. It is expected that HZ will be more frequent in immunocompromised (IC) individuals than in immunocompetent (IC-free). This study assessed the incidence rate (IR) of HZ in individuals with a wide set of IC conditions and in IC-free individuals. Read More

    Herpes zoster subunit vaccine for the prevention of herpes zoster.
    Am J Health Syst Pharm 2018 Jun;75(12):861-869
    Department of Pharmacy Practice and Administration, Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY.
    Purpose: Published literature on the efficacy and safety of the herpes zoster (HZ) subunit vaccine (HZ/su vaccine) in reducing the risks of HZ and postherpetic neuralgia (PHN) in adults 50 years of age and older, as well as the vaccine's properties and efficacy relative to live attenuated vaccine, is reviewed.

    Summary: HZ/su vaccine (Shingrix, GlaxoSmithKline) is a recently Food and Drug Administration (FDA)-approved vaccine indicated for the prevention of HZ in adults 50 years of age and older. Based on several Phase III trials, the Advisory Committee on Immunization Practices has preferentially recommended HZ/su vaccine over a live attenuated vaccine previously approved by FDA. Read More

    Valacyclovir-induced Neurotoxicity in a Patient with a Preserved Renal Function.
    Intern Med 2018 Jun 6. Epub 2018 Jun 6.
    Department of General Internal Medicine, Matsushita Memorial Hospital, Japan.
    Valacyclovir, a prodrug of acyclovir, is the first-line treatment for herpes zoster, but the renal function must be monitored, because acyclovir is metabolized by the kidneys. We herein report a case of valacyclovir-induced neurotoxicity with no preceding renal impairment. An 88-year-old man was admitted because of an impaired consciousness after the administration of valacyclovir at 3,000 mg daily for herpes zoster on the chest. Read More

    Quantifying the incidence and burden of herpes zoster in New Zealand general practice: a retrospective cohort study using a natural language processing software inference algorithm.
    BMJ Open 2018 May 31;8(5):e021241. Epub 2018 May 31.
    Department of Primary Health Care and General Practice, University of Otago, Wellington, New Zealand.
    Objective: To investigate the incidence of primary care presentations for herpes zoster (zoster) in a representative New Zealand population and to evaluate the utilisation of primary healthcare services following zoster diagnosis.

    Design: A cross-sectional retrospective cohort study used a natural language processing software inference algorithm to identify general practice consultations for zoster by interrogating 22 million electronic medical record (EMR) transactions routinely recorded from January 2005 to December 2015. Data linking enabled analysis of the demographics of each case. Read More

    Increased Risk of Herpes Zoster Infection in Patients with Inflammatory Bowel Diseases in Korea.
    Clin Gastroenterol Hepatol 2018 May 29. Epub 2018 May 29.
    Departments of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:
    Background & Aims: Few data are available on risk of herpes zoster (HZ) infection in Asian patients with inflammatory bowel diseases (IBD). We investigated whether patients with IBD in Korea have an increased risk of HZ and sought to identify risk factors for infection.

    Methods: We performed a nationwide population-based study and a hospital-based, nested case-control study. Read More

    Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial.
    Lancet 2018 May 24;391(10135):2116-2127. Epub 2018 May 24.
    Stanford University School of Medicine, Stanford, CA, USA.
    Background: Recipients of autologous haemopoietic stem-cell transplants (auto-HSCT) have an increased risk of herpes zoster and herpes zoster-related complications. The aim of this study was to establish the efficacy and safety of an inactivated varicella zoster vaccine for the prevention of herpes zoster after auto-HSCT.

    Methods: In this randomised, double-blind, placebo-controlled phase 3 trial, participants were recruited from 135 medical centres (ie, stem-cell transplant centres and hospitals) in North America, South America, Europe, and Asia. Read More

    Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population.
    SSM Popul Health 2018 Apr 17;4:301-306. Epub 2018 Mar 17.
    Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil.
    Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and complex diseases. However, the role of BGA as a proxy for non-genetic health determinants has been little investigated. Read More

    A Systematic Review of Zosteriform Rash in Breast Cancer Patients: An Objective Proof of Flap Reinnervation and a Management Algorithm.
    Ann Plast Surg 2018 May 30. Epub 2018 May 30.
    Department of Obstetrics and Gynecology, Lebanese American University Medical Center, Beirut, Lebanon.
    Background: Zosteriform rash in cancer patients provides objective clues to the process of reinnervation of the reconstructed breast. This rash should also raise suspicion for metastasis, which can be confused with herpes zoster.

    Objectives: The aims of this study were to explain the reconstruction flap sensory reinnervation mechanism based on the clinical findings and provide a diagnostic and management algorithm of zosteriform rash in breast cancer patients. Read More

    Herpes Zoster Infection in Patients With Ulcerative Colitis Receiving Tofacitinib.
    Inflamm Bowel Dis 2018 May 30. Epub 2018 May 30.
    Pfizer Inc., Collegeville, Pennsylvania.
    Background: Tofacitinib is an oral, small molecule Janus kinase inhibitor that is being investigated for ulcerative colitis (UC). Tofacitinib is approved for rheumatoid arthritis and psoriatic arthritis, where it has been shown to increase herpes zoster (HZ) risk. We evaluated HZ risk among UC patients using tofacitinib. Read More

    Live zoster vaccination in an immunocompromised patient leading to death secondary to disseminated varicella zoster virus infection.
    Vaccine 2018 Jun 25;36(27):3890-3893. Epub 2018 May 25.
    Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia.
    In 2016, the live attenuated zoster vaccine (Zostavax, Merck and Co, USA) was introduced into the Australian National Immunisation Program for people aged 70 years who are not significantly immunocompromised. We report the administration of Zostavax in an immunocompromised patient with chronic lymphocytic leukaemia and no evidence of primary varicella zoster virus (VZV) infection. The patient presented with a bilateral vesicular facial rash 22 days after receiving Zostavax and was initially managed as an outpatient with oral acyclovir. Read More

    Increased Risk of Atrial Fibrillation in the Early Period after Herpes Zoster Infection: a Nationwide Population-based Case-control Study.
    J Korean Med Sci 2018 May 2;33(22):e160. Epub 2018 May 2.
    Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
    Background: Herpes zoster (HZ) is a chronic inflammatory disease that could result in autonomic dysfunction, often leading to atrial fibrillation (AF).

    Methods: From the Korean National Health Insurance Service database of 738,559 subjects, patients newly diagnosed with HZ (n = 30,685) between 2004 and 2011, with no history of HZ or AF were identified. For the non-HZ control group, 122,740 age- and sex-matched subjects were selected. Read More

    Varicella zoster virus infections in neurological patients: a clinical study.
    BMC Infect Dis 2018 May 25;18(1):238. Epub 2018 May 25.
    Department of Neurology, Hannover Medical School, Carl-Neuberg-Str-1, 30625, Hannover, Germany.
    Background: Varicella zoster virus (VZV) reactivation is a common infectious disease in neurology and VZV the second most frequent virus detected in encephalitis. This study investigated characteristics of clinical and laboratory features in patients with VZV infection.

    Methods: Two hundred eighty two patients with VZV reactivation that were hospitalized in the department of neurology in the time from 2005 to 2013 were retrospectively evaluated. Read More

    Sponsorship Bias in Base-Case Values and Uncertainty Bounds of Health Economic Evaluations? A Systematic Review of Herpes Zoster Vaccination.
    Med Decis Making 2018 May 1:272989X18776636. Epub 2018 May 1.
    Centre for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Wilrijk, Antwerp, Belgium (JB, FV, PB).
    Background: New health technologies are more likely adopted when they have lower incremental cost-effectiveness ratios (ICERs) and/or when their ICER is presented with more certainty. Industry-funded (IF) health economic evaluations use often more favorable base-case values, leading to more favorable conclusions.

    Purpose: To study whether IF health economic evaluations of varicella-zoster virus vaccination in the elderly use more favorable base-case values and account for less uncertainty than non-industry-funded (NIF) evaluations. Read More

    Varicella zoster virus as a possible trigger for the development of pityriasis lichenoides et varioliformis acuta: retrospective analysis of our institutional cases.
    Clin Exp Dermatol 2018 May 23. Epub 2018 May 23.
    Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.
    Although numerous infective agents, including varicella zoster virus (VZV), have been described in association with pityriasis lichenoides et varioliformis acuta (PLEVA) and pityriasis lichenoides chronica (PLC), none has been identified consistently in these lesions. We sought to immunohistochemically identify VZV glycoprotein (g)E antigens in the vascular endothelium in PLEVA and PLC lesions, based on our previous observation that gE was detected in the vascular endothelium and eccrine unit up until 2 months and 2.5, respectively, years after herpes zoster (HZ) infection. Read More

    Herpes zoster ophthalmicus: acute keratitis.
    Curr Opin Ophthalmol 2018 Jul;29(4):328-333
    University of California, Davis, UC Davis Eye Center Sacramento, California, USA.
    Purpose Of Review: Herpes zoster is a common condition, and involvement of the trigeminal nerve results in herpes zoster ophthalmicus (HZO). Acute keratitis is one of the most common of these ocular complications associated with HZO. The findings associated with and the management of acute zoster keratitis will be reviewed. Read More

    Herpes Zoster in Patients Receiving JAK Inhibitors For Ulcerative Colitis: Mechanism, Epidemiology, Management, and Prevention.
    Inflamm Bowel Dis 2018 May 17. Epub 2018 May 17.
    Henry D Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
    Increased risk of herpes zoster (HZ) has been observed in patients with immune-mediated diseases, including rheumatoid arthritis (RA), psoriasis (PsO), and inflammatory bowel disease; this risk can be further increased by the use of immunosuppressive therapy. One advancing modality of therapy for these diseases is Janus kinase (JAK) inhibition. Tofacitinib is an oral JAK inhibitor for the treatment of RA and psoriatic arthritis, which is currently under investigation for the treatment of ulcerative colitis (UC) and was previously investigated for psoriasis. Read More

    Skin lesions over the pocket area that may mimic cardiac implantable electronic device infection: A case series.
    Pacing Clin Electrophysiol 2018 May 21. Epub 2018 May 21.
    Arrhythmia Device and Electrophysiology Laboratory, University Hospital of Ioannina, Ioannina, Greece.
    Background: The early and correct diagnosis of cardiac implantable electronic device (CIED) infections is critical given that early aggressive treatment with complete removal of the system along with antimicrobial therapy dramatically improves outcomes. Pocket infection manifested by local signs of inflammation is the most common form of CIED infections. Conditions mimicking pocket infection have been described in the literature. Read More

    A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis.
    Case Rep Pediatr 2018 26;2018:6931206. Epub 2018 Mar 26.
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
    Some epidemiological studies have implied a pathogenetic association between varicella zoster virus (VZV) and multiple sclerosis (MS); this, however, remains controversial. The present report describes a case involving an immunocompetent 10-year-old girl who developed relapsing-remitting MS following the prolonged reactivation of VZV inside the first branch of the trigeminal nerve, exhibiting herpes zoster ophthalmicus with severe optic neuritis. Symptoms related to herpes zoster ophthalmicus and MS appeared consecutively in the 10-week period after the appearance of vesicles. Read More

    Clinico-Pathological Study of 4 Cases of Pseudoherpetic Grover Disease: The Same as Vesicular Grover Disease.
    Am J Dermatopathol 2018 Jun;40(6):445-448
    Departments of Dermatology, and.
    Introduction: Grover disease (GD) was described with 4 histopathological patterns, but later wide histopathological studies found additional ones including vesicular GD. From 2014, 2 new patterns, GD with epidermolytic hyperkeratosis and pseudoherpetic GD, have been proposed.

    Objectives: The authors present 4 cases of pseudoherpetic GD and review the 6 previously published cases to better characterize this variant clinically and histopathologically. Read More

    [A case report: Ramsay Hunt syndrome with throat as starting place merger ipsilateral cranial nerver involvement].
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 May;31(10):807-809
    The clinical data of a case of Ramsay Hunt syndrome concurrent with ipsilateral Ⅴ, Ⅶ, Ⅷ, Ⅸ, Ⅹ, Ⅺ cranial nerves paralysis with throat as starting place was retrospectively analyzed, and the relevant literatures were also reviewed. The case is rare, so the relevant clinical reports are less. It is important to take the objective data as well as subjective symptoms of the patients into consideration to make a definite diagnosis, so that we can treat it as soon as possible to achieve better curative effect. Read More

    Cross-sectional study on hospitalizations related to herpes zoster in an Italian region, 2008-2016.
    Aging Clin Exp Res 2018 May 15. Epub 2018 May 15.
    Department of Cardiac, Thoracic and Vascular Sciences, Hygiene and Public Health Unit, University of Padua, Via Loredan, 18, 35121, Padua, Italy.
    Introduction: To assess the burden of herpes zoster (HZ) by analyzing HZ-related hospital admissions.

    Methods: We conducted a population-based descriptive cross-sectional study on all hospitalizations for HZ among the resident population admitted to all public and accredited private hospitals in the Veneto Region (north-east Italy) during the years 2008-2016. HZ hospitalizations were identified from the International Classification of Diseases codes in the hospital discharge records. Read More

    A rapid magnetic particle-based enzyme immunoassay for human cytomegalovirus glycoprotein B quantification.
    J Pharm Biomed Anal 2018 Jul 17;156:372-378. Epub 2018 Apr 17.
    Analytical Spectroscopy and Sensors Group (GEAS), Institute of Environmental Sciences (IUCA), University of Zaragoza, c/Pedro Cerbuna 12, 50009, Zaragoza, Spain.
    Human cytomegalovirus (HCMV) is a herpes virus that can cause severe infections. Still, the available methods for its diagnostic have the main disadvantage of requiring long time to be performed. In this work, a simple magnetic particle-based enzyme immunoassay (mpEIA) for the quantification of glycoprotein B of Human cytomegalovirus (gB-HCMV) in urine samples is proposed. Read More

    High resolution vessel wall MRI and vasculopathy related to herpes zoster ophthalmicus.
    Clin Imaging 2018 May 3;50:336-339. Epub 2018 May 3.
    Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
    Varicella zoster virus is a common viral infection with over 50% of patients over the age of 80 years infected with the virus. Following reactivation, some patients succumb to complications of VZV reactivation with neurologic and optic pathway pathology such as VZV vasculopathy resulting in transient ischemic attacks, strokes, aneurysms, as well as optic neuritis. We show that high resolution vessel wall magnetic resonance imaging can aid in the diagnosis of this condition with circumferential wall thickening and enhancement of the infected vessels. Read More

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