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    In vivo confocal microscopy detects bilateral changes of corneal immune cells and nerves in unilateral herpes zoster ophthalmicus.
    Ocul Surf 2017 Sep 15. Epub 2017 Sep 15.
    Ocular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA; Boston Image Reading Center, Tufts University School of Medicine, Boston, MA, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. Electronic address:
    Purpose: To analyze bilateral corneal immune cell and nerve alterations in patients with unilateral herpes zoster ophthalmicus (HZO) by laser in vivo confocal microscopy (IVCM) and their correlation with corneal sensation and clinical findings.

    Materials And Methods: This is a prospective, cross-sectional, controlled single-center study. Twenty-four eyes of 24 HZO patients and their contralateral clinically unaffected eyes and normal controls (n = 24) were included. Read More

    [Scleritis and episcleritis].
    J Fr Ophtalmol 2017 Sep 12. Epub 2017 Sep 12.
    Service d'ophtalmologie, Nouvel hôpital civil, université de Strasbourg, hôpitaux universitaires, BP 426, 67091 Strasbourg, France.
    Episcleritis is generally a benign disease with a self-limited course, while scleritis is a severe ocular condition due to a risk of impaired vision in one-fifth of patients and its association with systemic diseases in one third of them. Infectious scleritis, representing 8 % of the etiologies, is mainly of herpetic origin (varicella zoster and herpes simplex viruses). A systemic autoimmune disease is observed in roughly 30 % of scleritis patients: inflammatory rheumatisms (15 %), firstly rheumatoid polyarthritis, systemic vasculitides (8 %), mainly granulomatosis with polyangiitis (Wegener's) and polychondritis, and less often inflammatory bowel disease and systemic lupus erythematosus. Read More

    [Efficiency of immunosuppressive therapy in virus-negative and virus-positive patients with morphologically verified lymphocytic myocarditis].
    Ter Arkh 2017 ;89(8):57-67
    I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.
    Aim: To evaluate the efficiency of immunosuppressive therapy (IST) in virus-negative (V-) and virus-positive (V+) patients with lymphocytic myocarditis (LM).

    Subjects And Methods: 60 patients (45 males) (mean age 46.7±11. Read More

    Development and evaluation of multiplex real-time PCR for diagnosis of HSV-1, VZV, CMV, and Toxoplasma gondii in patients with infectious uveitis.
    Diagn Microbiol Infect Dis 2017 Aug 9. Epub 2017 Aug 9.
    Department of Virology, Postgraduate Institute of Medical Education & Research, Chandigarh, India. 160 012. Electronic address:
    Infectious uveitis is a vision threatening inflammatory ocular disease wherein early diagnosis may prevent the loss of vision. The purpose of this study was to develop a multiplex real-time PCR for the diagnosis of Herpes simplex virus-1, Varicella zoster virus, cytomegalovirus and Toxoplasma gondii in patients with suspected infectious uveitis. A total of 126 intraocular samples (aqueous and vitreous humor) were collected and subjected to multiplex real-time PCR. Read More

    Update From the Advisory Committee on Immunization Practices.
    J Pediatric Infect Dis Soc 2017 Sep;6(3):215-218
    Texas A&M College of Medicine, Bryan.
    The Advisory Committee on Immunization Practices (ACIP), a group of medical and public health experts, meets 3 times per year to develop recommendations for vaccine use in the United States. The group has 15 voting members, and each member's term is 4 years. ACIP members and Centers for Disease Control and Prevention (CDC) staff discuss the epidemiology of vaccine-preventable diseases and vaccine research, effectiveness, safety data, and clinical trial results. Read More

    PCR detection of human herpesviruses in colonic mucosa of individuals with inflammatory bowel disease: Comparison with individuals with immunocompetency and HIV infection.
    PLoS One 2017 13;12(9):e0184699. Epub 2017 Sep 13.
    AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
    Background: Detection of human herpesviruses (HHVs) other than cytomegalovirus (CMV) in colonic mucosa of individuals with inflammatory bowel disease (IBD) remains unknown. This study identified eight HHVs in the colonic mucosa of individuals with IBD and compared the results with immunocompetent and human immunodeficiency virus (HIV)-infected individuals.

    Methods: A total of 89 individuals who had colorectal ulcer on colonoscopy were enrolled: 26 with immunocompetency (n = 26), 41 with IBD, and 22 with HIV infection. Read More

    Response to combination of mycophenolate mofetil, cyclosporin A and corticosteroid treatment in lupus nephritis patients with persistent proteinuria.
    Int J Rheum Dis 2017 Sep 13. Epub 2017 Sep 13.
    Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
    Objective: To study the response of lupus nephritis (LN) patients with persistent proteinuria (≥ 1 g/day after ≥ 6 months corticosteroid and single immunosuppressant treatment, or ≥ 3 g/day after ≥ 3 months of corticosteroid and single immunosuppressant treatment) to corticosteroid combined with two immunosuppressants, and to evaluate associated factors of response within 1 year.

    Method: A retrospective study of proteinuria and renal function observed in LN patients with persistent proteinuria after adding a second immunosuppressant at 3, 6, 9 and 12 months.

    Result: Twenty-one LN patients (100. Read More

    Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis.
    J Neurovirol 2017 Sep 11. Epub 2017 Sep 11.
    Division of Clinical Neuroscience, Section of Clinical Neurology, University of Nottingham, Nottingham University Hospital NHS Trust, Queen's Medical Centre, C Floor S Block, Nottingham, NG7 2UH, UK.
    Varicella zoster virus (VZV) infection has been implicated in multiple sclerosis (MS), but direct causal involvement has been disputed. Nevertheless, knowledge of VZV exposure is important, given the risk of serious complications of first exposure while undergoing immunosuppressive treatment, in particular with fingolimod. We distributed questionnaires to MS clinic patients, requesting information about history of chickenpox, sibling/household/occupational exposure, history of zoster (shingles), and disease-modifying treatment. Read More

    Prevaccination epidemiology of herpes zoster in Denmark: Quantification of occurrence and risk factors.
    Vaccine 2017 Sep 2. Epub 2017 Sep 2.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Background: Herpes zoster (HZ) is a vaccine-preventable disease caused by reactivation of the varicella-zoster virus. Unfortunately, formulation of recommendations on routine immunization is hampered by a lack of data on disease burden, since most countries do not record cases of HZ in the general population. We developed and validated an algorithm to identify HZ based on routinely collected registry data and used it to quantify HZ occurrence and risk factors in Denmark prior to marketing of the HZ vaccine. Read More

    [Diagnostics and management of herpes zoster ophthalmicus].
    Ophthalmologe 2017 Sep 4. Epub 2017 Sep 4.
    Universitäts-Augenklinik, Uveitis Zentrum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Deutschland.
    Herpes zoster (HZ, shingles) represents the secondary manifestation of an infection with varicellazoster virus (VZV). A reactivation of dormant VZV in the ophthalmic branch of the fifth cranial nerve leads to ophthalmic HZ (HZO). The predominantly older and immune compromised patients often present with eye involvement (approximately 50%) as well as characteristic skin changes. Read More

    Why aren't we prescribing more valaciclovir for Herpes infections of the eye? Is it time for a change of practice in New Zealand?
    Clin Exp Ophthalmol 2017 Sep 1. Epub 2017 Sep 1.
    Nelson Hospital, New Zealand.
    Based on the Herpetic Eye Disease Study,(1) aciclovir has been used in the prevention of recurrent Herpes Simplex Virus (HSV) keratitis for nearly 20 years.(2) At that time aciclovir (Zovirax) and topical trifluridine (Viroptic) were the medications available for use. Based on clinical evidence, oral aciclovir is also used in the treatment of Herpes Zoster Ophthalmicus. Read More

    Seroprevalence of cytomegalovirus in donors & opportunistic viral infections in liver transplant recipients.
    Indian J Med Res 2017 Apr;145(4):558-562
    Institute of Liver Disease and Transplantation, Gleneagles Global Health City, Chennai, India.
    Background & Objectives: Opportunistic virus infections are common in liver transplant (LT) recipients. There is a risk of developing infection with cytomegalovirus (CMV) and herpes-related viruses such as herpes simplex virus-1 and 2 (HSV-1 & 2), Epstein-Barr virus (EBV) and Varicella Zoster virus (VZV), reactivation of infection and recurrent infection. This study was conducted to determine CMV seropositivity in donors and its influence on LT recipients and seropositivity of CMV, HSV-1 and 2, EB viral capsid antigen (EBVCA) and VZV in LT recipients and their reactivation. Read More

    Vaccines for Older Adults.
    Consult Pharm 2017 Sep;32(9):6-13
    Several vaccine-preventable diseases-influenza, pneumonia, herpes zoster, and pertussis-threaten the health of older adults in the United States. Both the costs associated with treating these diseases and the potential to increase morbidity and mortality are high for this patient population. Pharmacists and other health care professionals play a significant role in ensuring the elderly patient receives the recommended vaccines at the recommended intervals. Read More

    PCR-based approach for qualitative molecular analysis of six neurotropic pathogens.
    Acta Virol 2017 ;61(3):273-279
    In the last few years, polymerase chain reaction analysis is frequently required to improve the detection of pathogen infections in central nervous system as a potential cause of neurological disorders and neuropsychiatric symptoms. The goal of this paper is to set up a fast, cheap and reliable molecular approach for qualitative detection of six neurotropic pathogens. A method based on PCR has been designed and implemented to guarantee the qualitative DNA detection of herpes simplex virus types 1 and 2 (HSVI/II), Epstein-Barr virus (EBV), cytomegalovirus (CMV), varicella-zoster virus (VZV), rubella virus (RUBV) and Toxoplasma gondii in the cerebrospinal fluid, where otherwise they are barely detectable. Read More

    Herpes Zoster as a Risk Factor for Incident Giant Cell Arteritis.
    Arthritis Rheumatol 2017 Aug 29. Epub 2017 Aug 29.
    Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
    Objectives: Histopathological studies have implicated herpes zoster (HZ) as a causative organism of giant cell arteritis (GCA). We assessed the epidemiologic association of HZ events with incident GCA.

    Methods: We performed a retrospective cohort study utilizing two, large, independent US administrative datasets (Medicare 5% and Truven MarketScan) with eligible subjects having 12 months of continuous coverage, >50 years old, and without history of GCA or polymyalgia rheumatica. Read More

    Herpes Zoster and Tofacitinib: Clinical Outcomes and the Risk of Concomitant Therapy.
    Arthritis Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Pfizer Inc., Collegeville, Pennsylvania.
    Objective: Patients with rheumatoid arthritis (RA) are at increased risk of herpes zoster (HZ), and the risk appears to be increased in patients treated with tofacitinib. The aim of this study was to evaluate whether concomitant treatment with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or glucocorticoids (GCs) contributes to the increased risk of HZ in RA patients treated with tofacitinib.

    Methods: HZ cases were identified from the databases of 2 phase I, 9 phase II, 6 phase III, and 2 long-term extension studies of tofacitinib in RA patients. Read More

    The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.
    Arthritis Rheumatol 2017 Aug 28. Epub 2017 Aug 28.
    Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
    Objective: Patients with rheumatoid arthritis (RA) are at increased risk of herpes zoster, and vaccination is recommended for patients ages 50 years and older, prior to starting treatment with biologic agents or tofacitinib. Tofacitinib is an oral JAK inhibitor for the treatment of RA. We evaluated its effect on the immune response and safety of live zoster vaccine (LZV). Read More

    Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents.
    J Infect Dis 2017 Jul;216(2):191-197
    Department of Pathology and Molecular Medicine.
    Background: Elderly long-term care residents often exhibit a myriad of risk factors for immune dysfunction, including chronic inflammation and multiple comorbid conditions, which undoubtedly contribute to their enhanced susceptibility to infection. Hence, understanding the factors required for optimal vaccine responsiveness is critical.

    Methods: We examined 187 elderly nursing home residents (aged 80-102 years) and 50 community-dwelling seniors (aged 60-75 years) immunized with the live-attenuated varicella-zoster virus (VZV) vaccine. Read More

    Keratitis in association with herpes zoster and varicella vaccines.
    Drugs Today (Barc) 2017 Jul;53(7):393-397
    Department of Ophthalmology, Mason Eye Institute, University of Missouri School of Medicine, Columbia, Missouri, USA.
    The objective of this review was to collect reports of keratitis in association with herpes zoster virus (HZV) or varicella zoster virus (VZV) vaccines. HZV vaccination is intended for at-risk adult populations and VZV vaccination is intended for all pediatric patients. We reviewed the literature and reports of keratitis in association with herpes zoster or varicella vaccine from the National Registry of Drug-Induced Ocular Side Effects and the World Health Organization. Read More

    Hospitalizations realted to herpes zoster infection in the Canary Islands, Spain (2005-2014).
    BMC Infect Dis 2017 Aug 24;17(1):586. Epub 2017 Aug 24.
    Area of Preventive Medicine & Public Health, Rey Juan Carlos University, Avda. Atenas s/n, 28922, Madrid, Spain.
    Background: Herpes zoster is an important problem of public health especially among the elderly in Spain.

    Methods: A population-based retrospective epidemiological study to estimate the burden of herpes zoster requiring hospitalization in the Canary Islands, Spain was conducted by using data from the national surveillance system for hospital data, Conjunto Mínimo Básico de Datos. Records of all patients admitted to hospital with a diagnosis of herpes zoster in any position and cases of primary diagnosis (ICD-9-MC codes 053. Read More

    Low Varicella Zoster Virus Seroprevalence Among Young Children in the Democratic Republic of the Congo.
    Pediatr Infect Dis J 2017 Aug 19. Epub 2017 Aug 19.
    1 Department of Epidemiology, University of California, Los Angeles, Los Angeles, CA; 2 Department of Microbiology, Kinshasa School of Medicine, Kinshasa, DRC; 3 Bill and Melinda Gates Foundation, Seattle, WA 4 McKing Consulting, Expanded Programme on Immunization, Kinshasa, DRC; 5 OpGen, Inc. Gaithersburg, MD; 6 Department of Social and Behavioral Health, School of Rural Public Health, Texas A & M University, College Station, TX; 7 Programme on Immunization, Kinshasa, DRC;8 Kinshasa School of Public Health, Kinshasa, DRC; 9National Institute for Biomedical (INRB), Kinshasa, DRC.
    Background: Varicella zoster virus (VZV) causes both varicella (chickenpox) and herpes zoster (shingles) and is associated with significant global morbidity. Most epidemiological data on VZV come from high-come countries and to date there are limited data on the burden of VZV in Africa.

    Methods: We assessed the seroprevalence of VZV antibodies among children in the Democratic Republic of Congo in collaboration with the 2013-2014 Demographic and Health Survey (DHS). Read More

    Herpesviruses excretion in saliva of pediatric transplant recipients.
    Transpl Infect Dis 2017 Aug 21. Epub 2017 Aug 21.
    University Pediatric Hospital "Centro Habana", Havana, Cuba.
    Background: Saliva samples could be used for follow-up of herpesviruses infection in the pediatric transplant recipients.

    Objective: With the aim of determining the frequency of herpesviral infections in saliva samples after transplantation, and the association with viremia and complications, a pilot longitudinal follow-up of pediatric Cuban transplanted recipients (kidney and liver) was performed.

    Methods: Quantitative real-time polymerase chain reaction of cytomegalovirus (CMV), Epstein-Barr virus, herpes simplex virus, human herpesevirus-6 (HHV6), varicella zoster virus, and human herpesvirus-8 were serially assayed in saliva and serum samples from 27 transplanted patients, during 32 weeks after the graft. Read More

    Juvenile systemic sclerosis: experience from a tertiary care center from India.
    Rheumatol Int 2017 Aug 22. Epub 2017 Aug 22.
    Division of Pediatric Rheumatology, Department of Pediatrics, All India Institute of Medical Sciences, AIIMS, New Delhi, India.
    Juvenile systemic sclerosis (JSSc) is a rare disorder with paucity of information on its treatment and longterm  outcome. Herein, we are sharing our experience with this rare entity. Case records of children, diagnosed to have systemic sclerosis attending Pediatric Rheumatology Clinic at All India Institute of Medical Sciences, New Delhi from January 1998 to June 2016 were reviewed. Read More

    Immunogenicity and safety of zoster vaccine live administered with quadrivalent influenza virus vaccine.
    Vaccine 2017 Aug 19. Epub 2017 Aug 19.
    Merck & Co., Inc., Kenilworth, NJ, USA.
    Objectives: Randomized, blinded, placebo-controlled trial to evaluate the safety and immunogenicity of ZOSTAVAX™ (ZV) administered concomitantly with quadrivalent inactivated influenza vaccine (IIV4) in adults≥50years of age (NCT02519855).

    Methods: Overall, 440 participants were randomized into the Concomitant Group (CG) and 442 into the Sequential Group (SG). The CG received ZV and IIV4 at separate injection sites on Day 1 and matching placebo at Week 4. Read More

    Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study.
    PLoS One 2017 22;12(8):e0179447. Epub 2017 Aug 22.
    Department of Health Policy and Management, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States.
    Objectives: The risk of herpes zoster (HZ) between patients with psoriasis receiving and not receiving systemic therapy has received increasing attention. This study investigated the association of psoriasis with the risk of HZ.

    Methods: We conducted a population-based retrospective cohort study by using the Taiwan National Health Insurance Research Database. Read More

    Comparison of efficacy of continuous epidural block and pulsed radiofrequency to the dorsal root ganglion for management of pain persisting beyond the acute phase of herpes zoster.
    PLoS One 2017 21;12(8):e0183559. Epub 2017 Aug 21.
    Department of Anesthesiology and Pain Medicine, School of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
    Background: There is little evidence regarding the effectiveness of intervention methods in the treatment of zoster-related pain (ZAP) after the acute phase of zoster. Generally, if ZAP remains after more than 180 days from its onset, the likelihood of pain reduction is very low; this condition is considered as a "well established" post-herpetic neuralgia (PHN). Although the clinical efficacy of intrathecal steroid injection and spinal cord stimulation (SCS) for ZAP management has been reported, these interventions are not widely used due to inherent disadvantages. Read More

    Infectious complications in multiple myeloma receiving autologous stem cell transplantation in the past 10 years.
    Int J Hematol 2017 Aug 20. Epub 2017 Aug 20.
    Division of Hematology/Medical Oncology, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehag-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
    Infection is one of the main causes of early-treatment mortality in multiple myeloma (MM) patients during autologous stem cell transplantation (autoSCT). In the present study, we sought to determine the incidence of, and risk factors for, infection during hospital stays after autoSCT. We retrospectively evaluated 324 autoSCT events that occurred in 285 MM patients between 2006 and 2015, and reviewed the clinical characteristics of patients and history of infections. Read More

    Complex Regional Pain Syndrome following an Episode of Herpes Zoster: A Case Report.
    J Orthop Case Rep 2017 Mar-Apr;7(2):25-28
    Louisiana State University School of Medicine, New Orleans, Louisiana, USA.
    Introduction: Complex regional pain syndrome (CRPS) is characterized by searing pain, hyperalgesia, edema, allodynia, and skin changes. CRPS may be difficult to diagnose and to treat given poorly understood mechanisms as well as its presentation of symptoms that may mimic common conditions such as joint stiffness in this condition as well as rheumatoid arthritis.

    Case Report: A 71-year-old female presented to our clinic post shingles of the right upper extremity. Read More

    Periocular manifestations of trigeminal trophic syndrome: A case series and literature review.
    Orbit 2017 Aug 16:1-4. Epub 2017 Aug 16.
    a Bristol Eye Hospital , Bristol , England, UK.
    Trigeminal trophic syndrome (TTS) is a condition whereby persistent facial ulceration presents consequent to central or peripheral insult to the trigeminal nerve. Lesions are created by repetitive self-inflicted manipulation and trauma of dysaesthetic skin within the trigeminal dermatome. We discuss four cases with aetiologies varied from presumed microvascular compromise to resection of cerebral meningioma, cerebrovascular accident, and herpes zoster ophthalmicus. Read More

    Temporal Association of Herpes Zoster Eruption Post-Aminolevulinic Acid Hydrochloride Photodynamic Therapy for Actinic Keratoses.
    J Drugs Dermatol 2017 Aug;16(8):817-818

    Herpes zoster is a common and painful disease caused by the reactivation of the varicella-zoster virus with a higher incidence and severity associated with increasing age as well as compromised immune status. Acute inciting events for this eruption are not always known, but can include illness, stress, and mechanical injury. Photodynamic therapy (PDT) is a widely used treatment modality for precancerous skin lesions that has not been previously associated with provoking a herpes zoster outbreak. Read More


    Herpes zoster in breast cancer: a case report.
    J Biomed Res 2017 Jul;31(4):370-372
    Department of Surgery, AJA University of Medical Sciences, Tehran, Iran.
    There is little information on herpes zoster infection in breast cancer patients as a complication during adjuvant chemotherapy. We report a case of herpes zoster in a 65-year-old woman presented with low grade fever and vital signs together with skin symptoms such as severe edema, irritation and itching in the left breast where there was wound drainage. PCR test revealed varicella zoster virus. Read More

    Focusing on the implementation of 21st century vaccines for adults.
    Vaccine 2017 Aug 11. Epub 2017 Aug 11.
    Department of Health Sciences, University of Florence, Viale GB Morgagni, 48, 50134 Florence, Italy. Electronic address:
    Adult immunization is a priority for public health, particularly in countries where an aging population has become increasingly more numerous. Protection against diseases which typically affect adults (like flu, pneumococcal diseases and Herpes zoster), the shift of age of infections which originally affected children (like measles), the decreasing protection with time for infections which need periodical booster doses of vaccines (Tdap), the availability of vaccines which can also impact on adult health (HPV) are only some examples of the importance of implementing targeted vaccination strategies. The possibility to reach high coverage with immunizations that can guarantee a fundamental improvement of health for adults and the elderly can only be achieved through a coordinated effort where all stakeholders, under the coordination of public health, contribute to issue recommendations; create a functioning database for vaccine coverage registration; promote formative courses for healthcare workers and continuous information for the public; increase vaccines uptake among healthcare workers, who need to give the first testimony on the relevance of immunization. Read More

    Safety of herpes zoster vaccination among inflammatory bowel disease patients being treated with anti-TNF medications.
    Aliment Pharmacol Ther 2017 Oct 14;46(7):668-672. Epub 2017 Aug 14.
    Section of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    Background: The risk of herpes zoster (HZ) is elevated in inflammatory bowel disease (IBD) patients treated with anti-TNF medications. While it is optimal to give herpes zoster vaccine prior to initiation of therapy clinical circumstances may not always allow this.

    Aim: To determine the safety of giving herpes zoster vaccine while patients are on anti-TNF therapy. Read More

    Clinical, epidemiological and etiological studies of adult aseptic meningitis: Report of 11 cases with varicella zoster virus meningitis.
    Rinsho Shinkeigaku 2017 Aug 11. Epub 2017 Aug 11.
    Department of Neurology, Brain Attack Center, Ota Memorial Hospital.
    We treated 11 cases (52.7 ± 14.9 years, all male) with varicella zoster virus (VZV) meningitis and 437 cases with adult aseptic meningitis from 2004 to 2016. Read More

    A Comparative Study of CSF Viral RNA Loads between HIV Positive Patients with Neurological Manifestations and Neurologically Asymptomatic HIV Patients.
    J Assoc Physicians India 2017 Aug;65(8):14-17
    Assistant Professor, Microbiology, JNUIMSRC, Jaipur, Rajasthan.
    Introduction: There are conflicting reports in literature about correlation of CSF viral RNA levels with neurological manifestations in HIV positive patients. Many studies in animals and human subjects have shown that CSF HIV-1 RNA can be useful as a specific marker of HIV induced neuropathology. To the contrary there are studies which show that neurological disease states can occur in absence of significant increase of CSF HIV RNA. Read More

    Shoulder pain due to cervical radiculopathy: an underestimated long-term complication of herpes zoster virus reactivation?
    Int Orthop 2017 Aug 10. Epub 2017 Aug 10.
    Department of Orthopaedics and Traumatology, Shoulder and Elbow Unit, Sapienza, University of Rome, Rome, Italy.
    Purpose: To evaluate if herpes zoster virus (HZV) reactivation may be considered in the aetiology of cervical radiculopathy.

    Methods: The study group was composed of 110 patients (52 M-58F;mean age ± SD:46.5 ± 6. Read More

    Wolf's post-herpetic isotopic response to tocilizumab for rheumatoid arthritis.
    Australas J Dermatol 2017 Aug 9. Epub 2017 Aug 9.
    Department of Dermatology, Tri-Service General Hospital, National Defence Medical Centre, Taipei, Taiwan.
    Immediate and delayed hypersensitivity reactions may occur after the first or many exposures to tocilizumab, and they have varying presentations. Here, we describe a Wolf's isotopic response that manifested in a patient as erythema on the same site of a previous healed herpes zoster infection. This phenomenon has rarely been reported in the literature. Read More

    Increased risk of a herpes zoster attack in patients receiving androgen deprivation therapy for prostate cancer.
    Andrologia 2017 Aug 8. Epub 2017 Aug 8.
    Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
    This study aimed to examine the association of herpes zoster (HZ) with androgen deprivation therapy (ADT) use among patients with prostate cancer (PC), using a population-based data set. The study sample for this study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We selected 877 patients with PC who had received ADT as the study group, while 849 patients with PC who had not received ADT served as the comparison group. Read More

    Rapid Evolving Unilateral Indurated Oozing Facial Plaques in a Patient with Head-and-Neck Cancer: Peripheral T-Cell Lymphoma Not Otherwise Specified (NOS).
    Open Access Maced J Med Sci 2017 Jul 19;5(4):476-479. Epub 2017 Jul 19.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Background: The sudden development of facial plaques and nodules may be an alarming clinical sign for underlying malignancies. Nevertheless, a broad range of inflammatory and infectious diseases must be considered as well in the differential diagnosis.

    Case Report: We report on a 53-year-old male patient with a left-sided cheek infiltration with oozing but no lymphadenopathy. Read More

    Herpes zoster prevention: A difficult problem to solve.
    Vaccine 2017 Aug 4. Epub 2017 Aug 4.
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
    The clinical relevance of herpes zoster (HZ) and its increased incidence in recent years has prompted a search for more effective measures of prevention and therapy. A number of vaccines has been developed. For two of them, the live attenuated HZ vaccine (LAHZV) and the adjuvanted recombinant subunit HZ vaccine (SUHZV), data regarding immunogenicity, efficacy, safety and reactogenicity have been collected. Read More

    Comparing optical coherence tomography findings in different aetiologies of infectious necrotising retinitis.
    Br J Ophthalmol 2017 Aug 1. Epub 2017 Aug 1.
    Department of Clinical Sciences and Community Health, University of Milan, Ophthalmological Unit, IRCCS-Cà Granda Foundation - Ospedale Maggiore Policlinico, Milan, Italy.
    Aims: To compare optical coherence tomography (OCT) features of active necrotising infectious retinitis (NIR) due to toxoplasmosis or herpesviruses and to determine distinctive OCT signs for these two causes of infectious retinitis.

    Methods: OCT scans from eyes with active NIR due to varicella zoster virus (VZV), herpes simplex virus (HSV), cytomegalovirus (CMV), and toxoplasmosis (TOXO) were reviewed. All images were evaluated for the presence of previously described OCT findings in TOXO-NIR and compared with the viral group. Read More

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