49,219 results match your criteria Herpes Simplex


Large, stable, contemporary interspecies recombination events in circulating human herpes simplex viruses.

J Infect Dis 2019 Apr 23. Epub 2019 Apr 23.

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

The ubiquitous human pathogens, HSV-1 and HSV-2, are distinct viral species that diverged about six million years ago. At least four small, ancient HSV-1 x HSV-2 interspecies recombination events have affected the HSV-2 genome, with recombinants and non-recombinants at each locus circulating today. However, it is unknown if interspecies recombination can affect other loci and if new recombinants continue to be generated. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jid/advance-article/doi/10.1093/inf
Publisher Site
http://dx.doi.org/10.1093/infdis/jiz199DOI Listing
April 2019
1 Read

Oncolytic Herpes Simplex Virus and PI3K Inhibitor BKM120 Synergize to Promote Killing of Prostate Cancer Stem-like Cells.

Mol Ther Oncolytics 2019 Jun 29;13:58-66. Epub 2019 Mar 29.

Brain Tumor Research Center, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Novel therapies to override chemo-radiation resistance in prostate cancer (PCa) are needed. Prostate cancer sphere-forming cells (PCSCs) (also termed prostate cancer stem-like cells) likely participate in tumor progression and recurrence, and they are important therapeutic targets. We established PCSC-enriched spheres by culturing human (DU145) and murine (TRAMP-C2) PCa cells in growth factor-defined serum-free medium, and we characterized stem-like properties of clonogenicity and tumorigenicity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S23727705193004
Publisher Site
http://dx.doi.org/10.1016/j.omto.2019.03.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468160PMC
June 2019
4 Reads

Treatment of Viral Infections During Pregnancy.

Clin Perinatol 2019 Jun 28;46(2):235-256. Epub 2019 Mar 28.

Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center Magee-Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA. Electronic address:

Viral infections are common complications of pregnancy. Although some infections have maternal sequelae, many viral infections can be perinatally transmitted to cause congenital or chronic infection in fetuses or infants. Treatments of such infections are geared toward reducing maternal symptoms and complications and toward preventing maternal-to-child transmission of viruses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clp.2019.02.009DOI Listing

Herpes Simplex Virus Proctitis Masquerading as Rectal Cancer.

Diseases 2019 Apr 21;7(2). Epub 2019 Apr 21.

Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

Herpes simplex virus (HSV) is the leading cause of proctitis in HIV-infected individuals. However, no cases of rectal masses secondary to HSV infection have been reported to date. Herein, we present the case of a 45-year-old man with HIV infection who developed rectal pain and bleeding, along with dysuria and voiding difficulty. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/diseases7020036DOI Listing

Development of lacrimal gland inflammation in the mouse model of herpes stromal keratitis.

Exp Eye Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA; Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:

Herpes stromal keratitis (HSK) is a chronic immunoinflammatory condition which develops in response to recurrent herpes simplex virus-1 (HSV-1) infection of the cornea. Patients with HSK often demonstrate the concurrence of corneal desiccation and the loss of blink reflex. However, the relationship between severity of HSK, level of basal tears and inflammation of the lacrimal gland is mostly unexplored. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835193013
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.04.022DOI Listing
April 2019
1 Read
2.709 Impact Factor

Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics.

PLoS One 2019 22;14(4):e0215487. Epub 2019 Apr 22.

Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar.

Objectives: To investigate the epidemiology of herpes simplex virus type 1 (HSV-1) in Latin America and the Caribbean.

Methods: Systematic review and meta-analytics guided by the Cochrane Collaboration Handbook and reported following the PRISMA guidelines.

Results: Thirty-three relevant reports were identified including 35 overall (and 95 stratified) seroprevalence measures, and five and nine proportions of virus isolation in genital ulcer disease (GUD) and in genital herpes, respectively. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215487PLOS

Factors associated with serious bacterial infections in infants ≤60 days with hypothermia in the emergency department.

Am J Emerg Med 2019 Apr 11. Epub 2019 Apr 11.

Division of Infectious Disease, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America.

Background: We sought to investigate risk factors for serious bacterial infection (SBI: bacterial meningitis, bacteremia, and urinary tract infection [UTI]) among infants ≤60 days of age presenting to the emergency department (ED) with hypothermia (temperature < 36 °C).

Methods: We performed a single center study over a 12-year period including all patients ≤60 days old with hypothermia, excluding patients who did not receive a blood culture and patients who received antibiotics prior to culture acquisition. The primary outcome was SBI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2019.04.015DOI Listing

Herpes Virus Infections Other than Cytomegalovirus in the Recipients of Hematopoietic Stem Cell Transplantation.

Infect Dis Clin North Am 2019 Jun;33(2):467-484

City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idc.2019.02.012DOI Listing

Longitudinal magnetic resonance imaging changes in Japanese encephalitis.

Brain Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, Asahi General Hospital, Chiba, Japan.

Background: Japanese encephalitis is a flavivirus that can cause pandemic encephalitis, and is prevalent in Southeast Asia and Australia. Brain images of patients with Japanese encephalitis are characterized by thalamic lesions, distinct from those seen in viral encephalopathies caused by the herpes simplex virus and West Nile virus.

Aim: Herein, we describe for the first time a time-dependent magnetic resonance imaging pattern in Japanese encephalitis in a 10-month-old Japanese boy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03877604183056
Publisher Site
http://dx.doi.org/10.1016/j.braindev.2019.04.005DOI Listing
April 2019
1 Read

Discovery of small molecule inhibitors targeting the E3 ubiquitin ligase activity of the HSV-1 ICP0 protein using an high throughput screening assay.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

University of Kansas Medical Center, Department of Microbiology, Molecular Genetics, Immunology, 3901 Rainbow Blvd, Building Hixon, room 3009, Kansas City, KS, 66160

Herpes simplex virus-1 (HSV-1) has infected more than 80% of the population. Reactivation of the virus causes diseases ranging in severity from benign cold sores to fatal encephalitis. Current treatments involve viral DNA replication inhibitors but emergence of drug resistant mutants is observed frequently, highlighting the need for novel anti-viral therapies. Read More

View Article

Download full-text PDF

Source
http://jvi.asm.org/lookup/doi/10.1128/JVI.00619-19
Publisher Site
http://dx.doi.org/10.1128/JVI.00619-19DOI Listing
April 2019
3 Reads

Sequential infection of herpes simplex virus, candida, and cytomegalovirus in esophagus.

Gastrointest Endosc 2019 Apr 14. Epub 2019 Apr 14.

Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, 1-1-1 Abuno, Takatsuki-city, Osaka 569-1045 Japan.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00165107193159
Publisher Site
http://dx.doi.org/10.1016/j.gie.2019.04.210DOI Listing
April 2019
1 Read

Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: Α prospective single- center study.

Transpl Infect Dis 2019 Apr 16:e13095. Epub 2019 Apr 16.

Pediatric Clinic, "P & A Kyriakou" Children's Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece.

Background: Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome.

Methods: In a prospective study from September 2011 to September 2015 blood, urine and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real-time polymerase chain reaction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tid.13095DOI Listing
April 2019
1 Read

The role of Langerhans cells in pathologies of the skin.

Immunol Cell Biol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, Dunedin School of Medicine, University of Otago, P O Box 56, Dunedin, New Zealand.

Langerhans cells (LCs) are epidermal immune cells of myeloid origin. Although these cells were primarily thought to play a defensive role in the skin, evidence now indicates a diverse range of LC-mediated effects including relay of viral antigens in herpes simplex infection, recruitment of eosinophils in atopic dermatitis, and promotion of a Th17 response in Candida infection. LCs may have a protective or suppressive function in pathologies of the skin, with differing functions being driven by the skin milieu. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imcb.12253DOI Listing
April 2019
1 Read

ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.

Nat Microbiol 2019 Apr 15. Epub 2019 Apr 15.

International Institute of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, China.

Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I) exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted by viruses. How the antiviral efficacy of IFN-I can be improved remains to be explored. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-019-0428-3DOI Listing
April 2019
1 Read

[Cutaneous Herpesvirus Infection].

Authors:
Daisuke Watanabe

Brain Nerve 2019 Apr;71(4):302-308

Dermatology, Aichi Medical University.

Among human herpes viruses, those known to cause neurological symptoms are the herpes simplex virus (HSV) types 1 and 2 and the varicella-zoster virus (VZV), which remain latent in the dorsal root ganglion. HSV causes herpes labialis, genital herpes, etc. VZV causes varicella during the primary infection, and shingles when reactivated. Read More

View Article

Download full-text PDF

Source
https://webview.isho.jp/journal/detail/abs/10.11477/mf.14162
Publisher Site
http://dx.doi.org/10.11477/mf.1416201266DOI Listing
April 2019
2 Reads

Efficacy of acyclovir for herpes simplex encephalitis: A protocol for a systematic review of randomized controlled trial.

Authors:
Wei Wang Meng Ji

Medicine (Baltimore) 2019 Apr;98(15):e15254

Background: Clinical researches indicate that acyclovir can be used to herpes simplex encephalitis (HSE). However, no systematic review has explored its efficacy for the treatment of HSE. Therefore, this study systematically will investigate the efficacy and safety of acyclovir for patients with HSE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015254DOI Listing
April 2019
1 Read

Recurrent Aphthous Stomatitis Caused by Cytomegalovirus, Herpes Simplex Virus, and Candida Species in a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2019 Apr 26;51(3):993-997. Epub 2019 Jan 26.

Department of Urology, Kyoto University Hospital, Kyoto, Japan.

Recipients of organ transplants are immunosuppressed and at high risk of oral infection. Oral diseases are often neglected compared with infections of other organs that typically confer higher morbidity. However, severe local symptoms hinder oral intake, decrease quality of life, and are sometimes lethal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.01.058DOI Listing
April 2019
1 Read

Marine Fungi from the Sponge : Biodiversity, Chemodiversity, and Biotechnological Potential.

Mar Drugs 2019 Apr 11;17(4). Epub 2019 Apr 11.

Mycotheca Universitatis Taurinensis, Department of Life Sciences and Systems Biology, University of Turin, Viale Mattioli 25, 10125 Turin, Italy.

The emergence of antibiotic resistance and viruses with high epidemic potential made unexplored marine environments an appealing target source for new metabolites. Marine fungi represent one of the most suitable sources for the discovery of new compounds. Thus, the aim of this work was (i) to isolate and identify fungi associated with the Atlantic sponge ; (ii) to study the fungal metabolites by applying the OSMAC approach (one strain; many compounds); (iii) to test fungal compounds for their antimicrobial activities. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/1660-3397/17/4/220
Publisher Site
http://dx.doi.org/10.3390/md17040220DOI Listing
April 2019
3 Reads

Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe.

Pediatr Blood Cancer 2019 Apr 12:e27752. Epub 2019 Apr 12.

Department of Pediatric Hematology and Oncology, Justus Liebig University Giessen, Giessen, Germany.

Background: Epstein-Barr virus (EBV) is linked to a variety of malignancies; most endemic Burkitt lymphoma (BL) harbor EBV, whereas only a subset of the cases of sporadic BL is EBV positive.

Procedure: We retrospectively determined the herpesvirus seroprevalence at the time of diagnosis in pediatric non-Hodgkin lymphoma (NHL) patients enrolled in NHL-BFM (Berlin-Frankfurt-Muenster) studies. We accessed the seroepidemiological data from 1147 patients that became available during 1990-2007. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pbc.27752DOI Listing
April 2019
1 Read

Transcriptome analysis of rare minnow (Gobiocypris rarus) infected by the grass carp reovirus.

Fish Shellfish Immunol 2019 Apr 8;89:337-344. Epub 2019 Apr 8.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. Electronic address:

Grass carp shares the largest portion of the aquaculture production in China, but hemorrhagic disease caused by grass carp reovirus (GCRV) often results in tremendous loss of fingerlings and yearlings, causing significant economic damages. However, it is difficult to study antiviral mechanisms in grass carp in vivo due to its large size and long reproductive cycle. Therefore, a small cyprinid species named rare minnow with high sensitivity to GCRV, is regarded as a useful model to study the mechanisms of this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.fsi.2019.04.013DOI Listing
April 2019
1 Read

Separate Gene Transfers into Pre- and Postsynaptic Neocortical Neurons Connected by mGluR5-Containing Synapses.

J Mol Neurosci 2019 Apr 10. Epub 2019 Apr 10.

Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, USA.

mGluR5-containing synapses have essential roles in synaptic plasticity, circuit physiology, and learning, and dysfunction at these synapses is implicated in specific neurological disorders. As mGluR5-containing synapses are embedded in large and complex distributed circuits containing many neuron and synapse types, it is challenging to elucidate the roles of these synapses and to develop treatments for the associated disorders. Thus, it would be advantageous to deliver different genes into pre- and postsynaptic neurons connected by a mGluR5-containing synapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-019-01317-9DOI Listing

Antagonizing the glucocorticoid receptor impairs explant-induced reactivation in mice latently infected with herpes simplex virus 1.

J Virol 2019 Apr 10. Epub 2019 Apr 10.

Oklahoma State University, Center for Veterinary Health Sciences, Department of Veterinary Pathobiology, Stillwater, OK 74078

Herpes simplex virus 1 (HSV-1) establishes life-long latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from latency and recurrent disease, the mechanism of action is not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00418-19DOI Listing
April 2019
1 Read

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.

Sci Transl Med 2019 Apr;11(487)

Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.

Neonatal herpes simplex virus (nHSV) infections cause devastating morbidity and mortality in infants. Most nHSV cases are associated with primary maternal infection, consistent with the hypothesis that maternal immunity is protective. In humans, we found HSV-specific neutralizing antibodies in newborns of immune mothers, indicating that placentally transferred HSV-specific antibody is protective. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.aau6039DOI Listing
April 2019
1 Read

[Customised infectiology - Immunogenetics].

Rev Med Suisse 2019 Apr;15(646):766-770

Service des maladies infectieuses, CHUV, 1011 Lausanne.

Recent discoveries in innate immunity together with improvements in the analysis of the human genome have led to the identification of factors that make certain individuals more susceptible to infections than other. We know understand why herpes simplex virus I, a virus with a minor burden in most individuals, is responsible for devastating encephalitis in children unable to detect primo-infection of neural cells. A growing number of patients are treated with immunosuppressive drugs in the field of oncology, organ transplantation and immunology. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

Short-term results of acellular porcine corneal stroma keratoplasty for herpes simplex keratitis.

Xenotransplantation 2019 Apr 10:e12509. Epub 2019 Apr 10.

China Regenerative Medicine International Limited, Wanchai, Hong Kong.

Background: Corneal transplantation is a common surgical intervention for restoring vision loss due to corneal damages. However, for cultural reasons, there is a huge shortage of donor corneas in China. Acellular porcine corneal stromas (APCSs) can be used as corneal substitutes in lamellar keratoplasty for corneal ulcers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/xen.12509DOI Listing
April 2019
1 Read

Deep targeted sequencing reveals the diversity of TRB-CDR3 repertoire in patients with preeclampsia.

Hum Immunol 2019 Apr 6. Epub 2019 Apr 6.

Department of Genetics, National Research Institute for Family Planning, Beijing, 100081, China; Graduate School of Peking Union Medical College, Beijing, 100730, China. Electronic address:

Preeclampsia (PE) is one of the major causes of maternal and perinatal mortality worldwide. This study aimed to determine the immunological characteristics of PE patients and normal pregnancy at the T cell receptor beta-chain (TRB) level by using high-throughput sequencing. High-throughput sequencing was performed to analyze the expression of TRB-CDR3 in circulating T cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humimm.2019.04.003DOI Listing
April 2019
1 Read

Comparative Transcriptomics Reveals the Role of the Toll-Like Receptor Signaling Pathway in Fluoride-Induced Cardiotoxicity.

J Agric Food Chem 2019 Apr 22. Epub 2019 Apr 22.

School of Public Health , Shanxi Medical University , Taiyuan , Shanxi 030001 , China.

Many studies have shown that fluorosis due to long-term fluoride intake has damaging effects on the heart. However, the mechanisms underlying cardiac fluorosis have not been illuminated in detail. We performed high-throughput transcriptome sequencing (RNA-Seq) on rat cardiac tissue to explore the molecular effects of NaF exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jafc.9b00312DOI Listing
April 2019
4 Reads

A series of in vitro and human studies of a novel lip cream formulation for protecting against environmental triggers of recurrent herpes labialis.

Clin Cosmet Investig Dermatol 2019 22;12:193-208. Epub 2019 Mar 22.

AVR Consulting, Ltd., Cheshire, UK.

Purpose: These studies describe the testing of a novel, daily-use lip cream designed for individuals with lips prone to recurrent herpes labialis (RHL) that protects against environmental triggers.

Subjects And Methods: In vitro occlusive and in vitro and in vivo photoprotection analyses, a characterization of normal vs dry lips, and a randomized, evaluator-blinded, clinical trial that assessed the lip cream in healthy subjects with dry lips were conducted. In the clinical trial, subjects applied the lip cream or were untreated and evaluated using transepidermal water loss (TEWL), corneometry, visual assessments of lip dryness, expert photographic evaluations, and subject-rated outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CCID.S179430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432897PMC
March 2019
1 Read

Hyperammonemia in a case of herpes simplex and anti-N-methyl-d-aspartate receptor encephalitis.

Brain Dev 2019 Apr 5. Epub 2019 Apr 5.

Department of Pediatrics, Seoul National University College of Medicine, Seoul National University Children's Hospital, Seoul, Republic of Korea. Electronic address:

Herpes simplex encephalitis (HSE) is a widely accepted risk factor for anti N-methyl-d-aspartate receptor (NMDAR) encephalitis. Association of inherited metabolic disease has never been reported in a patient with HSE and anti-NMDAR encephalitis. Herein, we report a case of pediatric HSE complicated by development of anti-NMDAR encephalitis; this patient showed subsequent recurrent, unexplained episodes of encephalopathy associated with hyperammonemia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.braindev.2019.03.013DOI Listing
April 2019
2 Reads

A step beyond the hygiene hypothesis-immune-mediated classes determined in a population-based study.

BMC Med 2019 Apr 9;17(1):75. Epub 2019 Apr 9.

Department of Psychiatry, Center for Research in Psychiatric Epidemiology and Psychopathology, Lausanne University Hospital, Prilly, Switzerland.

Background: Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12916-019-1311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454751PMC
April 2019
1 Read
7.249 Impact Factor

Conditional ablation of reactive astrocytes to dissect their roles in spinal cord injury and repair.

Brain Behav Immun 2019 Apr 5. Epub 2019 Apr 5.

Institute of Neuroscience, Key Laboratory of Molecular Neurobiology of Ministry of Education and the Collaborative Innovation Center for Brain Science, Second Military Medical University, Shanghai, China. Electronic address:

Astrocytes become reactive in response to spinal cord injury (SCI) and ultimately form a histologically apparent glial scar at the lesion site. It is controversial whether astrocytic scar is detrimental or beneficial to the axonal regeneration and SCI repair. Therefore, much effort has focused on understanding the functions of reactive astrocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbi.2019.04.016DOI Listing
April 2019
1 Read

[Clinical diagnosis and treatment of herpes simplex virus infection on oral mucosa in children].

Authors:
J Zou

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Apr;54(4):286-288

Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.04.016DOI Listing

Risk of severe herpes simplex virus infection in systemic lupus erythematosus: analysis of epidemiology and risk factors analysis in Taiwan.

Ann Rheum Dis 2019 Apr 6. Epub 2019 Apr 6.

Division of Allergy, Immunology, and Rheumatology, Department of Internal Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan

Objective: Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and keratitis. However, few attempts to analyse the associated incidence and risk factors have been made.

Methods: We enrolled patients with SLE recorded between 1997 and 2012 and compared the incidence rate (IR) of severe HSV infection, including meningoencephalitis, septicaemia, ocular and visceral involvement, and other specific complications demanding hospitalisation, with that of a non-SLE cohort. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214844DOI Listing
April 2019
2 Reads

HSV-2-encoded miRNA-H4 Regulates Cell Cycle Progression and Act-D-induced Apoptosis in HeLa Cells by Targeting CDKL2 and CDKN2A.

Virol Sin 2019 Apr 5. Epub 2019 Apr 5.

Guangzhou School of Clinical Medicine, Southern Medical University, Guangzhou, 510010, China.

MicroRNAs (miRNAs) encoded by latency-associated transcript are associated with both latent and acute stages of herpes simplex virus 2 (HSV-2) infection. In this study, miRNA-H4-5p and miRNA-H4-3p were ectopically expressed in HeLa cells to explore potential cellular targets of viral miRNAs and demonstrate their potential biological functions. The results showed that miRNA-H4-5p could reverse apoptosis induced by actinomycin D (Act-D) and promote cell cycle progression, but miRNA-H4-3p had no such obvious functions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12250-019-00101-8DOI Listing
April 2019
3 Reads

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

MiR-155-5p modulates HSV-1 replication via the epigenetic regulation of SRSF2 gene expression.

Epigenetics 2019 Apr 5:1-10. Epub 2019 Apr 5.

b Key Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital , First Affiliated Hospital of Shenzhen University , Shenzhen , P.R. China.

A previous study reported that miR-155-5p knockout mice were more resistant to herpes simplex virus type I (HSV-1) infection. However, the exact underlying molecular mechanism remains to be elucidated. Here, we demonstrated that HSV-1 infection upregulates miR-155-5p expression. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/15592294.2019.1
Publisher Site
http://dx.doi.org/10.1080/15592294.2019.1600388DOI Listing
April 2019
3 Reads

An Intra-Vaginal Zinc Oxide Tetrapod Nanoparticles (ZOTEN) and Genital Herpesvirus Cocktail Can Provide a Novel Platform for Live Virus Vaccine.

Front Immunol 2019 20;10:500. Epub 2019 Mar 20.

Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, IL, United States.

Herpes simplex virus type-2 (HSV-2) is a common cause of genital infections throughout the world. Currently no prophylactic vaccine or therapeutic cure exists against the virus that establishes a latent infection for the life of the host. Intravaginal microbivac is a developing out-of-the-box strategy that combines instant microbicidal effects with future vaccine-like benefits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435576PMC
March 2019
2 Reads

Correlation between herpes simplex virus neutralizing antibody titers determined by ELVIS cell and traditional plaque reduction assays.

PLoS One 2019 4;14(4):e0214467. Epub 2019 Apr 4.

Department of Medicine, Division of Infectious Diseases, Saint Louis University School of Medicine, St. Louis, Missouri, United States of America.

Preventive viral vaccine efficacy trials require large-scale sample analysis to quantitate immune responses and their correlation with infection outcomes. Traditional plaque reduction assays measure a functionally important form of humoral immunity, neutralizing antibody titer. These assays, however, are time-consuming and laborious. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214467PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448825PMC

PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.

J Biol Chem 2019 Apr 3. Epub 2019 Apr 3.

Laboratory of Molecular Immunobiology, Nara Institute of Science and Technology, Japan.

The innate immune system plays an essential role in initial recognition of pathogen infection by producing inflammatory cytokines and type I interferons. cGAS is a cytoplasmic sensor for DNA derived from DNA viruses. cGAS binding with DNA induces the production of cGAMP, a second messenger that associates with STING in endoplasmic reticulum (ER). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.RA118.005731DOI Listing
April 2019
4 Reads

Epidemiology and clinical features of viral anterior uveitis in southern Taiwan-diagnosis with polymerase chain reaction.

BMC Ophthalmol 2019 Apr 3;19(1):87. Epub 2019 Apr 3.

Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist, Kaohsiung, 833, Taiwan.

Background: To report the epidemiology and clinical features of viral anterior uveitis in patients in southern Taiwan.

Methods: A retrospective, case series study. HLA-B27 negative anterior uveitis patients with increased intraocular pressure or corneal edema seen at Kaohsiung Chang Gung Memorial Hospital from January 1, 2007 to January 31, 2018 had their aqueous sent for polymerase chain reaction analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-019-1093-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448235PMC
April 2019
2 Reads

Severe Facial Herpes Vegetans and Viremia in -Deficient Common Variable Immunodeficiency.

Front Pediatr 2019 19;7:61. Epub 2019 Mar 19.

Division of Allergy and Immunology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, United States.

With the accessibility of next-generation sequencing modalities, an increasing number of primary immunodeficiency disorders (PIDDs) such as common variable immunodeficiency (CVID) have gained improved understanding of molecular pathogenesis and disease phenotype with the identification of a genetic etiology. We report a patient with early-onset CVID due to an autosomal dominant loss-of-function mutation in who developed a severe herpes vegetans cutaneous infection as well as concurrent herpes simplex virus viremia. The case highlights features of CVID, unique aspects of NF-κB2 deficiency including susceptibility to herpesvirus infections, the detection of neutralizing anticytokine antibodies, and the complexity of medical management of patients with a PIDD that can be aided by a known genetic diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fped.2019.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433840PMC
March 2019
2 Reads

The Role of T Cells in Herpes Stromal Keratitis.

Front Immunol 2019 19;10:512. Epub 2019 Mar 19.

Biomedical and Diagnostic Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN, United States.

The blinding inflammatory lesion stromal keratitis (SK), which occurs in some patients in response to ocular herpes simplex virus (HSV) infection, represents mainly an immune cell mediated inflammatory response to the virus infection. The principal orchestrators of the immunopathological lesions are T cells although additional events participate that include the extent of recruitment of non-lymphoid cells, the extent of neoangiogenesis, and the extent of damage to nerve function. This review focuses on evidence that the balance of the functional subsets of T cells has a major impact on lesion severity and duration. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00512
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433787PMC
March 2019
6 Reads

Sexually Transmitted Diseases in the Emergency Department.

Emerg Med Clin North Am 2019 May;37(2):165-192

Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address:

Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.emc.2019.01.001DOI Listing
May 2019
1 Read

Analysis of herpes simplex type 1 gB, gD, and gH/gL on production of infectious HIV-1: HSV-1 gD restricts HIV-1 by exclusion of HIV-1 Env from maturing viral particles.

Retrovirology 2019 Apr 2;16(1). Epub 2019 Apr 2.

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 2000 Hixon Hall, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.

Background: We previously showed that the gM of HSV-1 could restrict the release of infectious HIV-1 from cells. In this study, we analyzed if the four HSV-1 glycoproteins (gD, gB, and gH/gL), which are the minimum glycoproteins required for HSV-1 entry, restricted the release of infectious HIV-1.

Results: Of these four glycoproteins, gD and gH/gL restricted the production of infectious HIV-1 from cells transfected with an infectious molecular clone of HIV-1 (strain NL4-3) while gB had no significant effect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12977-019-0470-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444546PMC
April 2019
1 Read

Clinical evaluation and cost analysis of a Trioplex real-time PCR assay for the detection and differentiation of herpes simplex virus 1 and 2 in cutaneous and mucocutaneous lesions.

J Med Microbiol 2019 Apr 2. Epub 2019 Apr 2.

1 City of Milwaukee Health Department Laboratory, Milwaukee, Wisconsin, USA.

Purpose: Herpes simplex virus (HSV) is a common lifelong sexually transmitted infection. HSV-1 typically manifests as oral cold sores, while HSV-2 is more traditionally associated with sexual transmission and infection. We have developed a real-time PCR (Trioplex) for the simultaneous detection of HSV-1 and -2 and the bacterial phage internal control (IC) MS2. Read More

View Article

Download full-text PDF

Source
https://www.microbiologyresearch.org/content/journal/jmm/10.
Publisher Site
http://dx.doi.org/10.1099/jmm.0.000971DOI Listing
April 2019
7 Reads

Pathology Clinic: Herpes Simplex Infection of the Pinna.

Ear Nose Throat J 2019 Mar 28;98(3):134-135. Epub 2019 Jan 28.

2 ENT Department, Salford Royal NHS Foundation Trust, Salford, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0145561318824510DOI Listing

A nasal hypertrophic lesion as a presentation of herpes simplex virus.

IDCases 2019 9;15:e00512. Epub 2019 Mar 9.

Department of Internal Medicine, Section of Infectious Diseases, Lincoln Medical Center, NY, USA.

Herpes simplex virus type 1 and type 2 (HSV-1 & HSV-2) are one of the leading causes of ulcer and blister lesions worldwide. These infections are latent with recurrences but many people may have a seropositive antibody yet remain asymptomatic. Although HSV presenting with hypertrophic lesions have been reported in the literature at urogenital, lung, and conjunctival sites, we describe a case of a mass lesion in the nasal cavity of a 46 year-old female with a history of human immunodeficiency virus (HIV). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22142509193001
Publisher Site
http://dx.doi.org/10.1016/j.idcr.2019.e00512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423995PMC
March 2019
5 Reads

Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues.

Adv Sci (Weinh) 2019 Mar 28;6(6):1802095. Epub 2019 Jan 28.

Department of Chemistry and iNano Interdisciplinary Nanoscience Centre Aarhus University Aarhus C 8000 Denmark.

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/advs.201802095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425433PMC