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    Plant-derived transcription factors for orthologous regulation of gene expression in the yeast Saccharomyces cerevisiae.
    ACS Synth Biol 2017 May 22. Epub 2017 May 22.
    Control of gene expression by transcription factors (TFs) is central in many synthetic biology projects where tailored expression of one or multiple genes is often needed. As TFs from evolutionary distant organisms are unlikely to affect gene expression in a host of choice, they represent excellent candidates for establishing orthogonal control systems. To establish orthogonal regulators for use in yeast (Saccharomyces cerevisiae), we chose TFs from the plant Arabidopsis thaliana. Read More

    Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events.
    Acta Neurol Belg 2017 May 20. Epub 2017 May 20.
    Department of Neurology, Medical School, UNIMES, Universidade Metropolitana de Santos, Avenida Conselheiro Nebias 536, Santos, SP, CEP 11045-002, Brazil.
    Fingolimod was the first oral medication approved for management of multiple sclerosis and is currently used by tens of thousands patients worldwide. Fingolimod acts via the sphingosine 1-phosphate (S1P) receptor, maintaining peripheral lymphocytes entrapped in the lymph nodes. In consequence, there is a reduction in the infiltration of aggressive lymphocytes into the central nervous system. Read More

    Herpesvirus Capsid Assembly and DNA Packaging.
    Adv Anat Embryol Cell Biol 2017 ;223:119-142
    Department of Biological Sciences, Duquesne University, Pittsburgh, PA, 15282, USA.
    Herpes simplex virus type I (HSV-1) is the causative agent of several pathologies ranging in severity from the common cold sore to life-threatening encephalitic infection. During productive lytic infection, over 80 viral proteins are expressed in a highly regulated manner, resulting in the replication of viral genomes and assembly of progeny virions. The virion of all herpesviruses consists of an external membrane envelope, a proteinaceous layer called the tegument, and an icosahedral capsid containing the double-stranded linear DNA genome. Read More

    Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.
    Adv Anat Embryol Cell Biol 2017 ;223:49-75
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, 02115, USA.
    Innate immune responses play a major role in the control of herpes simplex virus (HSV) infections, and a multiplicity of mechanisms have emerged as a result of human evolution to sense and respond to HSV infections. HSV in turn has evolved a number of ways to evade immune detection and to blunt human innate immune responses. In this review, we summarize the major host innate immune mechanisms and the HSV evasion mechanisms that have evolved. Read More

    Herpes simplex virus Membrane Fusion.
    Adv Anat Embryol Cell Biol 2017 ;223:29-47
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164, USA.
    Herpes simplex virus mediates multiple distinct fusion events during infection. HSV entry is initiated by fusion of the viral envelope with either the limiting membrane of a host cell endocytic compartment or the plasma membrane. In the infected cell during viral assembly, immature, enveloped HSV particles in the perinuclear space fuse with the outer nuclear membrane in a process termed de-envelopment. Read More


    Construction of Various γ34.5 Deleted Fluorescent-Expressing Oncolytic herpes Simplex type 1 (oHSV) for Generation and Isolation of HSV-Based Vectors
    Iran Biomed J 2017 07;21(4):206-217
    Department of Virology, Pasteur Institute of Iran, Tehran, Iran.
    Background: Oncolytic herpes simplex virus (oHSV)-based vectors lacking γ34.5 gene, are considered as ideal templates to construct efficient vectors for (targeted) cancer gene therapy. Herein, we reported the construction of three single/dually-flourescence labeled and γ34. Read More

    [Update on congenital and neonatal herpes infections: infection due to cytomegalovirus and herpes simplex].
    Rev Neurol 2017 May;64(s03):S29-S33
    Hospital Universitario La Paz, Madrid, Espana.
    Newborn infants are a population which is especially susceptible to viral infections that frequently affect the central nervous system. Herpes infections can be transmitted to the foetus and to the newborn infant, and give rise to severe clinical conditions with long-term sensory and cognitive deficits. Two thirds of newborn infants with encephalitis due to herpes simplex virus and half of the children with symptomatic congenital infection by cytomegalovirus develop sequelae, which results in high community health costs in the long term. Read More

    Herpes simplex virus glycoprotein D targets a specific dendritic cell subset and improves the performance of vaccines to human papillomavirus-associated tumors.
    Mol Cancer Ther 2017 May 18. Epub 2017 May 18.
    Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo
    Cervical cancer is a major public health problem and one of the leading causes of cancer deaths in women. Virtually all cases of cervical cancer, as well as a growing share of anal and head/neck tumors, are associated with human papillomavirus (HPV) infection. Despite the effectiveness, the available prophylactic vaccines do not benefit women with cervical lesions or cancer. Read More

    Low-molecular weight mannogalactofucans prevent herpes simplex virus type 1 infection via activation of Toll-like receptor 2.
    Int J Biol Macromol 2017 May 15;103:286-293. Epub 2017 May 15.
    Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi-do 14662, Korea. Electronic address:
    Low-molecular-weight mannogalactofucans (LMMGFs, <4000g/mol) were prepared by the enzymatic degradation of Undaria pinnatifida sporophyll galactofucan (MF) and evaluated or their antiviral activities and underlying action mechanisms against herpes simplex virus type 1 (HSV-1). The 50% inhibitory concentrations (IC50) of LMMGFs and MF were 2.64 and 2. Read More

    AmpliVue Is a Practical and Timely Test for the Detection of HSV From Keratitis Specimens.
    Eye Contact Lens 2017 May 16. Epub 2017 May 16.
    University of Pittsburgh Medical Center (UPMC), The Charles T. Campbell Ophthalmic Microbiology Laboratory, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
    Objective: The laboratory diagnostic detection of herpes simplex virus (HSV) from eye samples must be practical, timely, and definitive for appropriate therapy. Although polymerase chain reaction (PCR) and/or cell culture can be definitive, HSV results can be delayed. Enzyme Linked Virus Inducible System (ELVIS) is a test that can provide results within 24 to 48 hr. Read More

    Racial/Ethnic Disparities at the End of an HIV Epidemic: Persons Who Inject Drugs in New York City, 2011-2015.
    Am J Public Health 2017 May 18:e1-e7. Epub 2017 May 18.
    Don C. Des Jarlais, Kamyar Arasteh, Courtney McKnight, Jonathan Feelemyer, and David Perlman are with Icahn School of Medicine at Mount Sinai, New York, NY. Susan Tross and Aimee Campbell are with Department of Psychiatry, Columbia University, New York. Samuel Friedman is with National Research and Development Institutes, New York.
    Objectives: To examine whether racial/ethnic disparities persist at the "end of the HIV epidemic" (prevalence of untreated HIV infection < 5%; HIV incidence < 0.5 per 100 person-years) among persons who inject drugs (PWID) in New York City.

    Methods: We recruited 2404 PWID entering New York City substance use treatment in 2001 to 2005 and 2011 to 2015. Read More

    [How I treat… a neonatal Herpes simplex virus infection].
    Rev Med Liege 2017 May;72(5):223-226
    Département de Pédiatrie, Secteur de Pneumologie Pédiatrique,CHC Espérance, Montegnée, Belgique.
    Neonatal herpes simplex virus infection is rare but important to recognize because of the major risk of sequelae or death. The diagnosis is mainly based on specific clinical and biological analyses. Aciclovir is the treatment of choice, duration of administration depending on the severity of the disease. Read More

    Burden of herpes simplex virus encephalitis in the United States.
    J Neurol 2017 May 17. Epub 2017 May 17.
    Department of Neurology, Henry Ford Hospital, 2799 W Grand Blvd, Detroit, MI, 48202, USA.
    Herpes simplex virus encephalitis (HSVE) is a disease of public health concern, but its burden on the healthcare of United States has not been adequately assessed recently. We aimed to define the incidence, complications and outcomes of HSVE in the recent decade by analyzing data from a nationally representative database. Healthcare Cost and Utilization Project databases were utilized to identify patients with primary discharge diagnosis of HSVE. Read More

    Epidemiology of herpes simplex virus type 1 and 2 in Italy: a seroprevalence study from 2000 to 2014.
    J Prev Med Hyg 2017 Mar;58(1):E27-E33
    Department of Molecular and Developmental Medicine, University of Siena, Italy.
    Herpes simplex viruses (HSV) are among the most widespread causative agents of human viral infections. HSV-2 is one of the commonest causes of genital disease, while HSV-1 is associated primarily with orolabial ulceration; however, recent changes in HSV epidemiology showed an increase in genital and neonatal herpes particularly caused by HSV-1. The main purpose of this study was to assess the seroprevalence of HSV-1 and HSV-2 in a random population in Siena (central Italy) in 2000, 2005 and 2013-2014 and in Bari (southern Italy) in 2005. Read More

    Cell cycle-dependent expression of AAV2 Rep in HSV-1 co-infections gives rise to a mosaic of cells replicating either AAV2 or HSV-1.
    J Virol 2017 May 17. Epub 2017 May 17.
    Institute of Virology, University of Zurich, Zurich, Switzerland
    Adeno-associated virus 2 (AAV2) depends for productive replication on the simultaneous presence of a helper virus such as herpes simplex virus type 1 (HSV-1). At the same time, AAV2 efficiently blocks the replication of HSV-1, which would eventually limit its own replication by diminishing the helper virus reservoir. This discrepancy begs the question how AAV2 and HSV-1 can co-exist in a cell population. Read More

    Sexual network drivers of HIV and herpes simplex virus type 2 (HSV-2) transmission: a comparative mathematical modeling analysis.
    AIDS 2017 May 16. Epub 2017 May 16.
    aDivision of Bioinformatics, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, 001-0020, Japan bInfectious Disease Epidemiology Group, Weill Cornell Medicine - Qatar, Cornell University, Qatar Foundation - Education City, Doha, Qatar cDepartment of Healthcare Policy and Research, Weill Cornell Medicine, Cornell University, New York, New York, USA dJST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan eCollege of Public Health, Hamad bin Khalifa University, Doha, Qatar.
    Objectives: HIV and herpes simplex virus type 2 (HSV-2) infections are sexually transmitted and propagate in sexual networks. Using mathematical modeling, we aimed to quantify effects of key network statistics on infection transmission, and extent to which HSV-2 prevalence can be a proxy of HIV prevalence.

    Design/methods: An individual-based simulation model was constructed to describe sex partnering and infection transmission, and was parameterized with representative natural history, transmission, and sexual behavior data. Read More

    Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation.
    Indian J Ophthalmol 2017 Apr;65(4):276-281
    Ocular Microbiology Services, L. V. Prasad Eye Institute, Bhubaneswar, Orissa; Jhaveri Microbiology Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
    Background: Microsporidial stromal keratitis poses several diagnostic challenges. Patients may present with corneal ulceration, marked stromal thinning, or even as a quite corneal scar. The presentation of microsporidial stromal keratitis commonly mimics viral keratitis. Read More

    Herpes Simplex 1 and Periopathogen Role in Peri-implantitis.
    J Contemp Dent Pract 2017 May 1;18(5):399-404. Epub 2017 May 1.
    Department of Periodontics, Thai Moogambigai Dental College, Chennai, Tamil Nadu, India, e-mail:
    Introduction: The objectives of this study were to compare the qualitative and quantitative profiles of herpes simplex virus type I (HSV-1) in implant surfaces between participants with peri-implantitis (PI) and Healthy peri-implant tissues and to quantitatively assess the relation between HSV-1 and periopathogens inside the microbiological profile associated with PI.

    Materials And Methods: A total of 40 patients with PI and 40 with healthy peri-implant tissues (HI) were recruited. Plaque samples from peri-implant sulcus and internal implant connections were analyzed using quantitative real-time polymerase chain reaction to detect and quantify HSV-1 and periodonto-pathogens. Read More

    Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype.
    MBio 2017 May 16;8(3). Epub 2017 May 16.
    Department of Microbiology-Immunology, Feinberg School of Medicine of Northwestern University, Chicago, Illinois, USA
    Glycoprotein B (gB) is the conserved herpesvirus fusion protein, and it is required for the entry of herpesviruses. The structure of the postfusion conformation of gB has been solved for several herpesviruses; however, the gB prefusion crystal structure and the details of how the protein refolds from a prefusion to a postfusion form to mediate fusion have not been determined. Using structure-based mutagenesis, we previously reported that three mutations (I671A, H681A, and F683A) in the C-terminal arm of the gB ectodomain greatly reduced cell-cell fusion. Read More

    Migrating microbes: what pathogens can tell us about population movements and human evolution.
    Ann Hum Biol 2017 May 16:1-11. Epub 2017 May 16.
    d Department of Anthropology & Geography, Human Origins and Palaeoenvironmental Research Group (HOPE) , Oxford Brookes University , Oxford , UK.
    Background: The biology of human migration can be observed from the co-evolutionary relationship with infectious diseases. While many pathogens are brief, unpleasant visitors to human bodies, others have the ability to become life-long human passengers. The story of a pathogen's genetic code may, therefore, provide insight into the history of its human host. Read More

    Clinical Markers and Outcomes of Neonates With Herpes Simplex Virus Deoxyribonucleic Acid Persistence in Cerebrospinal Fluid in Disseminated and Central Nervous System Infection.
    J Pediatric Infect Dis Soc 2017 May 16. Epub 2017 May 16.
    Department of Pediatrics and.
    We compared the clinical course of neonates with persistence of herpes simplex virus (HSV) deoxyribonucleic acid (DNA) in the cerebrospinal fluid (CSF) after 21 days of treatment with high-dose acyclovir to that of neonates with clearance of the CSF after 21 days of therapy. Neonates with persistence of HSV DNA had a more severe clinical course with worse neurodevelopmental outcomes. Read More

    Disseminated Neonatal Herpes Simplex Virus Type 1 After a Water Birth.
    J Pediatric Infect Dis Soc 2017 May 16. Epub 2017 May 16.
    University of Ottawa, Department of Pediatrics, Division of Neonatology.
    Neonatal herpes simplex virus (NHSV) infections are associated with significant morbidity and mortality. Numerous factors influence the transmission of HSV infection to newborns; however, immersion in water during labor has received very little attention as a possible risk factor despite the increasing popularity of water births. We report a case of disseminated NHSV type 1 infection, possibly acquired during a water birth. Read More

    Surgical excision for recurrent herpes simplex virus 2 (HSV-2) anogenital infection in a patient with human immunodeficiency virus (HIV).
    Infection 2017 May 15. Epub 2017 May 15.
    Division of Infectious Diseases, Vanderbilt University Medical Center, A2200 MCN 1161 21st Avenue South Nashville, Nashville, TN, 37232-2605, USA.
    Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. Read More

    Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy.
    Oncoimmunology 2017 7;6(4):e1264563. Epub 2016 Dec 7.
    Department of Surgery, Duke University Medical Center, Durham, NC, USA.
    Purpose: Although local oncolytic viral therapy (OVT) may enhance tumor lysis, antigen release, and adaptive immune responses, systemic antitumor responses post-therapy are limited. Adoptive immunotherapy with autologous dendritic cells (DC) and cytokine-induced killer cells (DC-CIK) synergizes with systemic therapies. We hypothesized that OVT with Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor (HSV-GM-CSF) would induce adaptive T cell responses that could be expanded systemically with sequential DC-CIK therapy. Read More

    The Herpesvirus Nuclear Egress Complex Component, UL31, Can Be Recruited to Sites of DNA Damage Through Poly-ADP Ribose Binding.
    Sci Rep 2017 May 15;7(1):1882. Epub 2017 May 15.
    Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada.
    The herpes simplex virus (HSV) UL31 gene encodes a conserved member of the herpesvirus nuclear egress complex that not only functions in the egress of DNA containing capsids from the nucleus, but is also required for optimal replication of viral DNA and its packaging into capsids. Here we report that the UL31 protein from HSV-2 can be recruited to sites of DNA damage by sequences found in its N-terminus. The N-terminus of UL31 contains sequences resembling a poly (ADP-ribose) (PAR) binding motif suggesting that PAR interactions might mediate UL31 recruitment to damaged DNA. Read More

    Extended Clinical Spectrum of Anti-N-Methyl-d-Aspartate Receptor Encephalitis in Children: A Case Series.
    Pediatr Neurol 2017 Apr 5. Epub 2017 Apr 5.
    Saul R. Korey Department of Neurology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
    Objective: There is a wide spectrum of clinical manifestations in children with anti-N-methyl-d-aspartate (NMDA) receptor antibody encephalitis from two different health care settings.

    Methods: We describe our experience with 13 patients (median age, 7 years; range, 5 months to 19 years) presenting to tertiary referral centers in India and the United States.

    Results: Initial manifestations were neurological (seizures or movement disorders) in eight patients, and psychiatric (e. Read More

    Novel Insights in Fetal Cardiomyopathy due to in utero Herpes Simplex Virus Infection.
    Fetal Diagn Ther 2017 May 16. Epub 2017 May 16.
    Department of Obstetrics, Charité Universitätsmedizin Berlin, Berlin, Germany.
    This is a case report of fatal cardiomyopathy in a fetus following maternal intrauterine infection with herpes simplex virus (HSV), despite the mother having no symptoms of an infection. The fetus showed signs of a disseminated infection affecting the heart, brain, lungs, liver, adrenal glands, and skin. HSV cardiomyopathy, characterized by vast necrosis, extensive calcifications, and inflammatory infiltration, was found to be the cause of intrauterine fetal death. Read More

    A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target.
    Transl Oncol 2017 May 12;10(4):476-484. Epub 2017 May 12.
    Division of Oncology, Hematology and Infectious Diseases, Department of Internal Medicine, Fukuoka University, ​7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.
    Background: We constructed a genetically modified adenovirus vector incorporating an IgG Fc-binding motif from staphylococcal protein A, Z33 (Adv-FZ33). Adv-FZ33 allows an antibody to redirect the vector to a target molecule on the cell surface. We attempted to search for target antigen candidates and antibodies that allowed highly selective gene transduction into malignant tumors. Read More

    The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
    Nucleic Acids Res 2017 May 13. Epub 2017 May 13.
    Manchester Institute of Biotechnology, School of Chemistry, Faculty of Science and Engineering, The University of Manchester, Manchester M1 7DN, UK.
    The transcription factor ICP4 from herpes simplex virus has a central role in regulating the gene expression cascade which controls viral infection. Here we present the crystal structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its own promoter, revealing a novel homo-dimeric fold. We also studied the complex in solution by small angle X-Ray scattering, nuclear magnetic resonance and surface-plasmon resonance which indicated that, in addition to the globular domain, a flanking intrinsically disordered region also recognizes DNA. Read More

    Acute retinal necrosis: presenting characteristics and clinical outcomes in a cohort of polymerase chain reaction-positive patients.
    Am J Ophthalmol 2017 May 10. Epub 2017 May 10.
    Johns Hopkins University School of Medicine, The Wilmer Eye Institute, 733 North Broadway, Baltimore, Maryland; Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 North Wolfe Street, Baltimore, Maryland.
    Purpose: To identify determinants of adverse outcomes in acute retinal necrosis (ARN), presenting characteristics and incidence rates of vision loss and ocular complications in a cohort of polymerase chain reaction (PCR)-positive eyes were analyzed.

    Design: Retrospective, observational cohort study.

    Methods: Forty-one eyes of 36 patients with clinically-diagnosed ARN, PCR-positive for herpes simplex virus or varicella zoster virus and evaluated between January 2002 and June 2013, were included. Read More

    Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129.
    Mol Neurodegener 2017 May 12;12(1):38. Epub 2017 May 12.
    State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.
    Background: Herpes simplex virus type 1 strain 129 (H129) has represented a promising anterograde neuronal circuit tracing tool, which complements the existing retrograde tracers. However, the current H129 derived tracers are multisynaptic, neither bright enough to label the details of neurons nor capable of determining direct projection targets as monosynaptic tracer.

    Methods: Based on the bacterial artificial chromosome of H129, we have generated a serial of recombinant viruses for neuronal circuit tracing. Read More

    Identification of factors associated with treatment refractoriness of oral lesions in pemphigus vulgaris.
    Br J Dermatol 2017 May 12. Epub 2017 May 12.
    Department of Virology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Oral mucosal lesions of pemphigus vulgaris (PV) are known to show more treatment refractoriness than skin lesions.

    Objectives: To identify the role of different clinical and laboratory parameters in the treatment refractoriness in the oral lesions of PV.

    Methods: This prospective study recruited 50 adult patients of PV having oral lesions. Read More

    Fundamentals of Clinical Pharmacology With Application for Pregnant Women.
    J Midwifery Womens Health 2017 May 12. Epub 2017 May 12.
    Medication use is common in pregnancy, yet for most medications the optimal formulation and dosage have not been described specifically for pregnant women. Often, adverse effects are only discovered anecdotally or after extensive off-label use occurs. Since pharmacologic research that includes pregnant women is sparse and animal studies are often not applicable to the human fetus, providers must use knowledge of drug behavior and normal physiologic changes of pregnancy to personalize treatment for pregnant women. Read More

    Intratumoral Injection of HSV1716, an Oncolytic Herpes Virus, Is Safe and Shows Evidence of Immune Response and Viral Replication in Young Cancer Patients.
    Clin Cancer Res 2017 May 11. Epub 2017 May 11.
    Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.
    Purpose: HSV1716 is an oncolytic herpes simplex virus-1 (HSV-1) studied in adults via injection into the brain and superficial tumors. To determine the safety of administering HSV1716 to pediatric patients with cancer, we conducted a phase I trial of image-guided injection in young patients with relapsed or refractory extracranial cancers.Experimental Design: We delivered a single dose of 10(5) to 10(7) infectious units of HSV1716 via computed tomography-guided intratumoral injection and measured tumor responses by imaging. Read More

    Long-term outcomes of the Boston type I keratoprosthesis in eyes with previous herpes simplex virus keratitis.
    Br J Ophthalmol 2017 May 11. Epub 2017 May 11.
    Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
    Purpose: To report the long-term outcomes of the Boston type I keratoprosthesis (Kpro) in eyes with prior herpes simplex virus (HSV) keratitis.

    Methods: Retrospective review of all Kpro procedures performed by a single surgeon from 1 May 2004 to 1 January 2015.

    Results: 13 of 173 Kpro procedures were performed in 11 eyes with prior HSV keratitis. Read More

    Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review.
    J Ethnopharmacol 2017 May 8. Epub 2017 May 8.
    Pharmacy, School of Medicine, University of Tasmania, 7001 Hobart, Tasmania, Australia.
    Ethnopharmacological Relevance: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. Read More

    Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study.
    Open Forum Infect Dis 2017 22;4(2):ofx050. Epub 2017 Mar 22.
    University of Alabama at Birmingham.
    Background: Infection is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Our object was to better define the epidemiology and outcomes of infections after HCT.

    Methods: This was a prospective, multicenter cohort study of HCT recipients and conducted from 2006 to 2011. Read More

    Understanding the Role of Chemokines and Cytokines in Experimental Models of Herpes Simplex Keratitis.
    J Immunol Res 2017 9;2017:7261980. Epub 2017 Apr 9.
    Department of Ophthalmology, Saint Louis University, Saint Louis, MO, USA.
    Herpes simplex keratitis is a disease of the cornea caused by HSV-1. It is a leading cause of corneal blindness in the world. Underlying molecular mechanism is still unknown, but experimental models have helped give a better understanding of the underlying molecular pathology. Read More

    Herpes virus seroepidemiology in the adult Swedish population.
    Immun Ageing 2017 10;14:10. Epub 2017 May 10.
    Department of Clinical Microbiology, Virology, Umeå University, Umeå, Sweden.
    Background: Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex type 1 (HSV1), Herpes simplex type 2 (HSV2), Cytomegalovirus (CMV), Varicella Zoster virus (VZV) and Human herpes virus type 6 (HHV6) in an adult Swedish population (35-95 years of age).

    Methods: Presence of antibodies against the respective viruses in serum from individuals in the Betula study was determined with an enzyme-linked immunosorbent assay (ELISA). Read More

    Dok-1 and Dok-2 are required to maintain herpes simplex virus 1-specific CD8(+) T cells in a murine model of ocular infection.
    J Virol 2017 May 10. Epub 2017 May 10.
    INRS-Institut Armand-Frappier, Laval, Québec, CANADA
    Dok-1 and Dok-2 negatively regulate responses downstream of several immune receptors in lymphoid and myeloid cells. Recent evidence showed that Dok proteins are essential in the formation of memory CD8(+) T cells to an exogenous epitope expressed by vaccinia virus; however, the importance of Dok-1 and Dok-2 in the control of viral infection is unknown. Herein, we investigated the role of Dok proteins in modulating the immune response against herpes simplex virus 1 (HSV-1) in a mouse model of ocular infection. Read More

    The C-terminus of the herpes simplex virus pUL25 protein is required for release of viral genomes from capsids bound to nuclear pores.
    J Virol 2017 May 10. Epub 2017 May 10.
    Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA., USA.
    The herpes simplex virus (HSV) capsid is released into the cytoplasm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along microtubules targets it to the nuclear envelope. Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid protein pUL25 and the capsid-tethered tegument protein pUL36. Temperature-sensitive mutants in both pUL25 and pUL36 dock at the NPC but fail to release DNA. Read More

    Roles of M1 and M2 macrophages in herpes simplex virus-1 infectivity.
    J Virol 2017 May 10. Epub 2017 May 10.
    Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC - SSB3, 8700 Beverly Blvd., Los Angeles, CA
    Macrophages are the predominant infiltrate in the corneas of mice that have been ocularly infected withHSV-1. However, very little is known concerning the relative roles of M1 (classically activated or polarized) and M2 (alternatively activated or polarized) macrophages in ocular HSV-1 infection. To better understand these relationships, we assessed the impact of directed M1 or M2 activation of RAW264. Read More

    Patterns of prevalent HPV and STI co-infections and associated factors among HIV-negative young Western Cape, South African women: the EVRI trial.
    Sex Transm Infect 2017 May 10. Epub 2017 May 10.
    Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida, USA.
    Objective: To estimate the prevalence and describe the patterns of concurrent human papillomavirus (HPV) and STIs and associated factors among HIV-negative young Western Cape, South African women participating in the Efficacy of HPV Vaccine to Reduce HIV Infection (EVRI) trial.

    Methods: HIV-negative women aged 16-24 years old were enrolled in the EVRI trial (NCT01489527) and randomised to receive the licensed four-valent HPV vaccine or placebo. At study entry, participants were clinically evaluated for five STIs: herpes simplex virus type 2 (HSV-2), chlamydia, gonorrhoea, syphilis and disease-causing HPV genotypes (6/11/16/18/31/33/35/39/45/51/52/56/58/59/68). Read More

    Bilateral Herpetic Keratitis After Bilateral Intravitreal Bevacizumab for Exudative Macular Degeneration.
    Cornea 2017 May 9. Epub 2017 May 9.
    *Retina Consultants of Houston, Houston, TX; and†Blanton Eye Institute, Houston Methodist Hospital & Weill Cornell Medical College, Houston, TX.
    Purpose: To report a case of bilateral herpetic epithelial keratitis after bilateral intravitreal bevacizumab injections for the treatment of exudative age-related macular degeneration.

    Methods: A 66-year-old man with diabetes and an extensive history of bilateral anti-vascular endothelial growth factor treatments for exudative age-related macular degeneration received an intravitreal bevacizumab injection in the right eye and triple therapy (bevacizumab, photodynamic therapy, and triamcinolone acetonide) in the left eye. After 4 days, he presented with pain, photophobia, tearing, and decreased vision in both eyes. Read More

    Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections.
    Food Chem Toxicol 2017 May 6. Epub 2017 May 6.
    Department of Virology, Medical University of Lublin, Poland.
    The dichloromethane extract from fruits of Angelica archangelica L. was separated by the modern high-performance countercurrent chromatography (HPCCC). The extract and five pure compounds: xanthotoxin, bergapten, imperatorin, phellopterin and isoimperatorin, and the mixture of imperatorin and phellopterin, have been studied as the potential antiviral agents against Herpes simplex virus type l and Coxsackievirus B3. Read More

    Human Cytomegalovirus-Induced Degradation of CYTIP Modulates Dendritic Cell Adhesion and Migration.
    Front Immunol 2017 21;8:461. Epub 2017 Apr 21.
    Department of Immunomodulation, University Hospital Erlangen, Erlangen, Germany.
    As potent antigen-presenting cells, dendritic cells (DCs) are essential for the initiation of effective antiviral immune responses. Viruses and especially herpesviruses, which are able to establish lifelong persistence, exploit several immune evasion mechanisms targeting DC biology. Our group has previously shown that the α-herpesvirus herpes simplex virus type 1 inhibits mature DC (mDC) migration by inducing adhesion via degrading the cellular protein CYTIP (cytohesin-1 interacting protein), an important negative regulator of β2-integrin activity. Read More

    A Trivalent Subunit Antigen Glycoprotein Vaccine as Immunotherapy for Genital Herpes in the Guinea Pig Genital Infection Model.
    Hum Vaccin Immunother 2017 May 8. Epub 2017 May 8.
    a Infectious Disease Division, Department of Medicine , Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania , United States of America.
    An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease. Some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. A vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (VZV), a closely related member of the Herpesviridae family. Read More

    UNUSUAL MANIFESTATION OF NEUROBORELIOSIS (CASE REPORT).
    Georgian Med News 2017 Mar(264):72-75
    Tbilisi State Medical University, Neurological Department of the First University Clinic, Georgia.
    The paper reported the verified case of neuroboreliosis with unusual clinical presentation of Parkinsonism. Study aimed at establishing the significance of a precise differential diagnosis with substantial analysis of the symptoms of several diseases to avoid the false diagnosis and to conduct the opportune and adequate therapeutic management. We described the case of the diagnosed neuroboreliosis with clinical expression of Multiple Sclerosis (MS) and Parkinsonism. Read More

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