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    Flow Virometry: A powerful tool to functionally characterize viruses.
    J Virol 2017 Nov 22. Epub 2017 Nov 22.
    Department of Pathology and Cell biology, University of Montreal, C.P. 6128, Succursale Centre-Ville, Montreal, Québec, Canada H3C 3J7
    For several decades, flow cytometry has been a common approach to analyze cells and sort them to near purity. It enables one to probe inner cellular molecules, surface receptors or infected cells. However, the analysis of smaller entities such as viruses and exocytic vesicles has been more difficult but is becoming mainstream. Read More

    Herpes simplex type 1 pneumonitis and acute respiratory distress syndrome in a patient with chronic lymphatic leukemia: a case report.
    J Med Case Rep 2017 Nov 23;11(1):329. Epub 2017 Nov 23.
    Interdisciplinary Intensive Care Unit, SRO AG Spital Langenthal, St. Urbanstrasse 67, 4901, Langenthal, Switzerland.
    Background: Pulmonary pathogenicity of herpes simplex virus type 1 in patients in intensive care without classic immunosuppression as well as the necessity of antiviral treatment in the case of herpes simplex virus detection in respiratory specimens in these patients is controversial. We present a case of acute respiratory distress syndrome in a patient with stable chronic lymphatic leukemia not requiring treatment, in whom we diagnosed herpes simplex virus type 1 bronchopneumonitis based on herpes simplex virus type 1 detection in bronchoalveolar lavage fluid and clinical response to antiviral treatment.

    Case Presentation: A 72-year-old white man presented with symptoms of lower respiratory tract infection. Read More

    Recurrent aphthous stomatitis in 18-year-old adolescents - Prevalence and associated factors: a population-based study.
    An Bras Dermatol 2017 Sep-Oct;92(5):626-629
    Post-Graduation Program in Health and Behavior, Universidade Católica de Pelotas (UCPEL)- Pelotas (RS), Brazil.
    Background: Recurrent aphthous stomatitis is a painful disorder of unknown etiology. It is among the most common oral mucosal lesions with high prevalence among young adults.

    Objectives: To conduct a population-based study with 18-year-old army recruiters to assess its prevalence and associated factors in male adolescents. Read More

    Promoting Simultaneous Onset of Viral Gene Expression Among Cells Infected with Herpes Simplex Virus-1.
    Front Microbiol 2017 1;8:2152. Epub 2017 Nov 1.
    Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Synchronous viral infection facilitates the study of viral gene expression, viral host interactions, and viral replication processes. However, the protocols for achieving synchronous infections were hardly ever tested in proper temporal resolution at the single-cell level. We set up a fluorescence-based, time lapse microscopy assay to study sources of variability in the timing of gene expression during herpes simplex virus-1 (HSV-1) infection. Read More

    A Therapeutic Antiviral Antibody Inhibits the Anterograde Directed Neuron-to-Cell Spread of Herpes Simplex Virus and Protects against Ocular Disease.
    Front Microbiol 2017 31;8:2115. Epub 2017 Oct 31.
    Institute of Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
    Herpes simplex virus (HSV) is a leading cause of blindness and viral encephalitis in the developed world. Upon reactivation from sensory neurons, HSV returns via axonal transport to peripheral tissues where it causes, e.g. Read More

    Pharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection.
    Front Microbiol 2017 31;8:2108. Epub 2017 Oct 31.
    Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago, Chile.
    Heme oxygenase-1 (HO-1) is an inducible enzyme that is expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), as well as cytokines, among others. Its activity can be positively modulated by cobalt protoporphyrin (CoPP) and negatively by tin protoporphirin (SnPP). Once induced, HO-1 degrades iron-containing heme into ferrous iron (Fe(2+)), carbon monoxide (CO) and biliverdin. Read More

    Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane.
    Sci Rep 2017 Nov 21;7(1):15931. Epub 2017 Nov 21.
    Department of Vaccine and Drug Development, Graduate School of Health Sciences, Kobe University, Kobe, 650-0047, Japan.
    Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). Read More

    Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study.
    BMJ 2017 Nov 21;359:j5018. Epub 2017 Nov 21.
    National Institute of Population Medical Genetics (INAGEMP), Porto Alegre, Brazil.
    Objective To describe the prevalence and clinical spectrum of microcephaly in South America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline for future surveillance as the Zika epidemic spreads and as other infectious causes may emerge in future.Design Prevalence and case-control study.Data sources ECLAMC (Latin American Collaborative Study of Congenital Malformations) database derived from 107 hospitals in 10 South American countries, 2005 to 2014. Read More

    Herpes Simplex Virus and Human Papillomavirus Coinfections in Hyperimmunoglobulin E Syndrome Presenting as a Conjunctival Mass Lesion.
    Case Rep Med 2017 12;2017:1650841. Epub 2017 Oct 12.
    Legal Medicine Organization, Rasht, Guilan, Iran.
    Hyperimmunoglobulin E syndrome (HIES) or Job's syndrome is a rare immunodeficiency disease with less than 200 cases reported worldwide, among which few cases are reported with lesions due to herpes simplex virus (HSV) or human papillomavirus (HPV). This case study presents a rare case of HIES with coinfection of HSV and HPV. A 12-year-old boy, previously diagnosed with HIES, presented with a large conjunctival mass lesion. Read More

    RNase 7 strongly promotes TLR9-mediated DNA sensing by human plasmacytoid dendritic cells.
    J Invest Dermatol 2017 Nov 17. Epub 2017 Nov 17.
    Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Germany.
    Plasmacytoid dendritic cells (pDCs) were described to accumulate in the skin of patients with psoriasis and to be recruited into the dermis upon allergen challenge in atopic dermatitis. Importantly, activation of pDCs in the skin has been identified as important initiator of psoriasis development. RNase 7 is one of the major antimicrobial peptides (AMP) secreted by keratinocytes and is expressed in significantly higher amounts in lesional skin of patients with atopic dermatitis or psoriasis than in healthy individuals. Read More

    Association between false-positive TORCH and antiphospholipid antibodies in healthy pregnant women.
    Lupus 2017 Jan 1:961203317741564. Epub 2017 Jan 1.
    1 Department of Obstetrics, Gynaecology and Pediatrics, Catholic University of Sacred Heart, Rome, Italy.
    The present study investigated: (a) the presence of antiphospholipid antibodies and (b) the obstetric outcome in healthy pregnant women showing false-positive TORCH-Toxoplasmosis, Other: syphilis, varicella-zoster, Rubella, Cytomegalovirus (CMV), and Herpes infections-results. Data from 23 singleton healthy pregnancies with false-positive TORCH results were collected. Each woman was systematically screened for TORCH IgG and IgM during the pre-conception assessment and/or at the beginning of pregnancy. Read More

    MicroRNA-373 facilitates HSV-1 replication through suppression of type I IFN response by targeting IRF1.
    Biomed Pharmacother 2017 Nov 15;97:1409-1416. Epub 2017 Nov 15.
    Department of Pediatric Dentistry, The Affiliated Stomatology Hospital of Chongqing Medical University, Chongqing 400015, China; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 400015, China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400015, China. Electronic address:
    Herpes simplex virus type 1 (HSV-1) had led to kinds of clinical disorders and became an important cause of morbidity and mortality worldwide, such as herpetic gingivostomatitis in children. Previous studies reported that HSV-1 infection is common and has evolved a variety of mechanisms to evade the immune system, such as dysregulation of miRNAs. However, reports concerning the role of miRNA in HSV-1infection are limited. Read More

    A concise synthesis of rhamnan oligosaccharides with alternating α-(1→2)/(1→3)-linkages and repeating α-(1→3)-linkages by iterative α-glycosylation using disaccharide building blocks.
    Carbohydr Res 2017 Nov 14;455:23-31. Epub 2017 Nov 14.
    Department of Applied Bioorganic Chemistry, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan; Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1193, Japan.
    A concise synthetic route to rhamnan oligosaccharides with alternating α-(1→2)/(1→3)-linkages and repeating α-(1→3)-linkages is reported. This synthesis was achieved by iterative α-glycosylation using disaccharide building blocks and through orthogonal coupling between thioglycosides of L-rhamnose. To investigate the detailed structure-activity relationship of rhamnan sulfate from Monostroma nitidum against herpes simplex virus type 2, the synthesized oligosaccharides, bearing different orthogonal protecting groups (i. Read More

    How Does Imaging of Congenital Zika Compare with Imaging of Other TORCH Infections?
    Radiology 2017 Dec;285(3):744-761
    From the Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (D.L.); Departments of Obstetrics and Gynecology (J.C.J.) and Radiology (M.C.), University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium; Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium (M.C.); and Department of Radiology, Boston Medical Center, Boston University, Boston, Mass (I.C.).
    The acronym TORCH is used to refer to congenital infections, such as toxoplasmosis, other infections (such as syphillis, varicella-zoster, and parvovirus B19), cytomegalovirus, and herpes simplex virus. The classic findings in patients with TORCH infections include rash in the mother during pregnancy and ocular findings in the newborn. Zika virus has emerged as an important worldwide congenital infection. Read More

    A new promising candidate to overcome drug resistant herpes simplex virus infections.
    Antiviral Res 2017 Nov 15. Epub 2017 Nov 15.
    Department of Immune Modulation, University Hospital Erlangen, Erlangen, Germany. Electronic address:
    Infections with Herpes simplex viruses (HSV) belong to the most common human diseases worldwide, resulting in symptoms ranging from painful, but commonly self-limiting lesions of the orofacial or genital tract to severe infections of the eye or life-threatening generalized infections. Frequent HSV-reactivations at the eye may lead to the development of herpetic stromal keratitis, which is one of the major causes of infectious blindness in developed countries. The vast majority of life-threatening generalized infections occur in immunocompromised individuals, such as transplant recipients or patients suffering from advanced human immunodeficiency virus (HIV) infection with concurrent HSV-reactivation. Read More

    Patients with atopic dermatitis and history of eczema herpeticum elicit HSV-specific type 2 immune responses.
    J Allergy Clin Immunol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research, Hannover Medical School, Hannover, Germany.
    An increased type 2 and in parallel decreased type 1 T cell immune response to herpes simplex virus 1 may lead to the clinical phenotype of eczema herpeticum. Read More

    [Genital herpes and pregnancy: Epidemiology, clinical manifestations, prevention and screening. Guidelines for clinical practice from the French College of Gynecologists and Obstetrician (CNGOF)].
    Gynecol Obstet Fertil Senol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Gynaecology and Obstetrics, hôpital Louis-Mourier, hôpitaux universitaires Paris Nord, 147, rue des Renouillets, 92700 Colombes, France. Electronic address:
    Objectives: To analyze the consequences of genital herpes infections in pregnant women.

    Methods: The PubMed database and the recommendations from the French and foreign obstetrical societies or colleges have been consulted.

    Results: The symptomatology of herpes genital rash is often atypical (NP2) and not different during pregnancy (Professional consensus). Read More

    Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity.
    Brain Behav Immun 2017 Nov 13. Epub 2017 Nov 13.
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:
    Cognitive impulsivity is a heritable trait believed to represent the behavior that defines the volition to initiate alcohol drinking. We have previously shown that a neuronal Toll-like receptor 4 (TLR4) signal located in the central amygdala (CeA) and ventral tegmental area (VTA) controls the initiation of binge drinking in alcohol-preferring P rats, and TLR4 expression is upregulated by alcohol-induced corticotropin-releasing factor (CRF) at these sites. However, the function of the TLR4 signal in the nucleus accumbens shell (NAc-shell), a site implicated in the control of reward, drug-seeking behavior and impulsivity and the contribution of other signal-associated genes, are still poorly understood. Read More

    Bladder Herpes Infection in a Patient with Low-Grade Non-Muscle-Invasive Bladder Cancer.
    Urology 2017 Nov 13. Epub 2017 Nov 13.
    PhD. Urology Department. Hospital Universitario del Henares.
    Bladder herpes is a very uncommon event related to herpes simplex virus infection. We report a 69-year-old man with 4-year history of bladder cancer who presented with presented with dysuria and urinary frequency. Cystoscopy showed erythematous lesion of the bladder mucosa that was biopsied and revealed multi-lobed nuclei with eosinophilic intranuclear inclusions, and presence of intracytoplasmic vacuoles that were suggestive of bladder involvement by herpes simplex virus (HSV). Read More

    The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection.
    Viruses 2017 Nov 16;9(11). Epub 2017 Nov 16.
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
    Herpes simplex virus 1 (HSV-1) has extensive interactions with the host DNA damage response (DDR) machinery that can be either detrimental or beneficial to the virus. Proteins in the homologous recombination pathway are known to be required for efficient replication of the viral genome, while different members of the classical non-homologous end-joining (c-NHEJ) pathway have opposing effects on HSV-1 infection. Here, we have investigated the role of the recently-discovered c-NHEJ component, PAXX (Paralogue of XRCC4 and XLF), which we found to be excluded from the nucleus during HSV-1 infection. Read More

    Effective priming of HSV-specific CD8(+) T cells in vivo does not require infected dendritic cells.
    J Virol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
    Resolution of virus infections depends on the priming of virus-specific CD8(+) T cells by dendritic cells (DC). While this process requires MHC class I-restricted antigen presentation by DC, the relative contribution to CD8(+) T cell priming by infected DC is less clear. We have addressed this question in the context of a peripheral infection with herpes simplex virus type 1 (HSV). Read More

    Cerebral toxoplasmosis in an MS patient receiving Fingolimod.
    Mult Scler Relat Disord 2017 Nov 12;18:106-108. Epub 2017 May 12.
    Fundación Valle del Lili, Cali, Colombia; Universidad ICESI, Cali, Colombia. Electronic address:
    Multiple Sclerosis (MS) is an autoimmune disease in which lymphocytes target putative myelin antigens in the CNS, causing inflammation and neurodegeneration. Fingolimod (FTY720) is an immunosuppressive drug used as a second line therapy for relapsing forms of MS due to its safety profile and good response to treatment. Despite its safety, there are still concerns about the possibility of Fingolimod being linked to the development of opportunistic infections like disseminated varicella zoster infections and herpes simplex encephalitis. Read More

    Hiv Prevalence and Associated Risk Factors Among Men Who Have Sex With Men in Dar Es Salaam, Tanzania.
    J Acquir Immune Defic Syndr 2017 Nov 13. Epub 2017 Nov 13.
    *Department of Epidemiology and Biostatistics, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. †Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Norway ‡Department of Behavioural Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
    Introduction: Limited studies and differential risk behaviours among men who have sex with men(MSM) in Africa calls for population specific studies. We present results from the largest integrated bio-behavioural survey among MSM in Africa to inform programming.

    Methods: This was a cross-sectional study utilizing respondent driven sampling to recruit MSM aged 18 and above. Read More

    Herpes simplex virus-1 entrapped in Candida albicans biofilm displays decreased sensitivity to antivirals and UVA1 laser treatment.
    Ann Clin Microbiol Antimicrob 2017 Nov 14;16(1):72. Epub 2017 Nov 14.
    Department of Diagnostic, Clinic and Public Health Medicine, University of Modena and Reggio Emilia, Via del Pozzo 87, 41125, Modena, Italy.
    Background: Recently, we published data suggesting a mutualistic relationship between HSV-1 and Candida. albicans; in particular: (a) HSV-1 infected macrophages are inhibited in their anti-Candida effector function and (b) Candida biofilm protects HSV-1 from inactivation. The present in vitro study is aimed at testing the effects of Candida biofilm on HSV-1 sensitivity to pharmacological and physical stress, such as antiviral drugs (acyclovir and foscarnet) and laser UVA1 irradiation. Read More

    Neutropenic fever during peripheral blood progenitor cell mobilization is associated with decreased CD34+ cell collection and increased apheresis collection days.
    J Clin Apher 2017 Nov 14. Epub 2017 Nov 14.
    Blood & Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
    Background: Peripheral blood progenitor cell (PBPC) mobilization with chemotherapy in addition to Granulocyte-Colony Stimulating Factor (G-CSF) improves cell collection compared to G-CSF alone; however, it is associated with increased risk of neutropenic fever (NF).

    Methods: We analyzed risk factors for post-priming NF and NF association with autologous stem cell transplant outcomes. Between 1998 and 2008, 593 adult patients with lymphoma underwent PBPC mobilization with etoposide and G-CSF. Read More

    Non-contact lens related Acanthamoeba keratitis.
    Indian J Ophthalmol 2017 Nov;65(11):1079-1086
    Jhaveri Microbiology Centre, L. V. Prasad Eye Institute, Hyderabad, Telangana, India.
    The purpose of the study is to describe epidemiology, clinical features, diagnosis, and treatment of Acanthamoeba keratitis (AK) with special focus on the disease in nonusers of contact lenses (CLs). This study was a perspective based on authors' experience and review of published literature. AK accounts for 2% of microbiology-proven cases of keratitis. Read More

    Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review.
    Int Immunopharmacol 2017 Nov 10;54:131-138. Epub 2017 Nov 10.
    Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising treatment for PV. In this study, a systematic review was conducted to conclude on how and which PV patients could benefit from rituximab infusion. Read More

    Gene therapy with HSV encoding p55TNFR gene for HIV neuropathic pain: an evidence-based mini-review.
    Transl Perioper Pain Med 2017 ;2(4):24-32
    Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, Florida 33136.
    While effective antiretroviral treatment makes human immunodeficiency virus (HIV)-related death decreased dramatically, neuropathic pain becomes one of the most common complications in patients with HIV/acquired immunodeficiency syndrome (AIDS). The exact mechanisms of HIV-related neuropathic pain are not well understood yet, and no effective therapy is for HIV-pain. Evidence has shown that proinflammatory factors (e. Read More

    Dendritic cells in the cornea during Herpes simplex viral infection and inflammation.
    Surv Ophthalmol 2017 Nov 9. Epub 2017 Nov 9.
    Sydney Medical School, The University of Sydney, Sydney, Australia; Centre for Virus Research, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
    Herpes simplex keratitis is commonly caused by Herpes simplex Virus Type 1 (HSV-1), which primarily infects eyelids, corneas or conjunctiva. HSV-1- through sophisticated interactions with dendritic cells (DCs), a type of antigen-presenting cell)-initiates pro-inflammatory responses in the cornea. Corneas were once thought to be an immune privileged region; however, with the recent discovery of DCs that reside in the cornea, this long held conjecture has been overturned. Read More

    Impaired glutamatergic projection from the motor cortex to the subthalamic nucleus in 6-hydroxydopamine-lesioned hemi-parkinsonian rats.
    Exp Neurol 2017 Nov 8;300:135-148. Epub 2017 Nov 8.
    Department of Neurobiology, Capital Medical University, Beijing 100069, China; Key Laboratory for the Neurodegenerative Disorders of the Chinese Ministry of Education, Beijing 100069, China; Beijing Institute for Brain Disorders, Beijing 100069, China. Electronic address:
    The glutamatergic projection from the motor cortex to the subthalamic nucleus (STN) constitutes the cortico-basal ganglia circuit and plays a critical role in the control of movement. Emerging evidence shows that the cortico-STN pathway is susceptible to dopamine depletion. Specifically in Parkinson's disease (PD), abnormal electrophysiological activities were observed in the motor cortex and STN, while the STN serves as a key target of deep brain stimulation for PD therapy. Read More

    UPLC-PDA-ESI-qTOF-MS profiling and potent anti-HSV-II activity of Eucalyptus sideroxylon leaves.
    J Chromatogr B Analyt Technol Biomed Life Sci 2017 Nov 2;1068-1069:335-342. Epub 2017 Nov 2.
    Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Ainy, Cairo, 11562, Egypt. Electronic address:
    Eucalyptus is one of the most important and highly exploited genus in family Myrtaceae. An UPLC/PDA/ESI-qTOF-MS method was adopted to identify Eucalyptus sideroxylon Cunn. ex Woolls leaves phytoconstituents. Read More

    The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis.
    Sci Rep 2017 Nov 8;7(1):15103. Epub 2017 Nov 8.
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia (PA), USA.
    The trafficking behavior of the lipid raft-dwelling US9 protein from Herpes Simplex Virus strikingly overlaps with that of the amyloid precursor protein (APP). Both US9 and APP processing machinery rely on their ability to shuttle between endosomes and plasma membranes, as well as on their lateral accumulation in lipid rafts. Therefore, repurposing US9 to track/modify these molecular events represents a valid approach to investigate pathological states including Alzheimer's disease and HIV-associated neurocognitive disorders where APP misprocessing to amyloid beta formation has been observed. Read More

    Acta Clin Croat 2016 12;55(4):667-70
    Multifocal serpiginoid choroiditis is an infectious variety of serpiginous choroiditis. The disease is characterized by infectious etiology and overlapping clinical features in an intermediary form of acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis. In a 33-year-old patient, bilateral multiple placoid partially confluent chorioretinal lesions were diagnosed after a febrile flu-like episode. Read More

    Seropositivity to herpes simplex virus type 2, but not type 1 is associated with cervical cancer: NHANES (1999-2014).
    BMC Cancer 2017 Nov 7;17(1):726. Epub 2017 Nov 7.
    Laboratory of immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
    Background: Herpes simplex virus types 1 and 2 (HSV1 and HSV2) are infectious agents, and their association with cancer occurrence in human is a controversial topic for decades. We addressed this subject using all available continuous National Health and Nutrition Examination Survey (NHANES) cross-sectional data from 1999 to 2014.

    Methods: Eight data cycles (1999-2000, 2001-2002, 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, and 2013-2014) were employed, and a sample of 8184 female participants was used in this study according to the availability of cancer history and HSV serostatus. Read More

    CD335 (NKp46)(+) T-Cell Recruitment to the Bovine Upper Respiratory Tract during a Primary Bovine Herpesvirus-1 Infection.
    Front Immunol 2017 23;8:1393. Epub 2017 Oct 23.
    Vaccinology and Immunotherapeutics Program, School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada.
    Bovine natural killer (NK) cells were originally defined by the NK activation receptor CD335 [natural killer cell p46-related protein (NKp46)], but following the discovery of NKp46 expression on human T-cells, the definition of conventional bovine NK cells was modified to CD335(+)CD3(-) cells. Recently, a bovine T-cell population co-expressing CD335 was identified and these non-conventional T-cells were shown to produce interferon (IFN)-γ and share functional properties with both conventional NK cells and T-cells. It is not known, however, if CD335(+) bovine T-cells are recruited to mucosal surfaces and what chemokines play a role in recruiting this unique T-cell subpopulation. Read More

    Dynamic Proteomics of Herpes Simplex Virus Infection.
    MBio 2017 Nov 7;8(6). Epub 2017 Nov 7.
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
    The cellular response to viral infection is usually studied at the level of cell populations. Currently, it remains an open question whether and to what extent cell-to-cell variability impacts the course of infection. Here we address this by dynamic proteomics-imaging and tracking 400 yellow fluorescent protein (YFP)-tagged host proteins in individual cells infected by herpes simplex virus 1. Read More

    Lack of TNF-α signaling through p55 makes the mice more susceptible to acute infection but does not alter state of latency and reactivation of HSV-1.
    Virus Res 2017 Nov 4;244:1-5. Epub 2017 Nov 4.
    Institute of Science, Nirma University, Ahmedabad, Gujarat, India; Medical Virology Section, Laboratory of Clinical Investigation, NIAID, NIH, Bethesda, MD, USA. Electronic address:
    TNF-α has been shown to play an important role in pathogenesis and latency of HSV-1 infections. TNF-α signals through TNFR1 (p55) and TNFR2 (p75), and signaling through p55 generally results in gene activation leading to induction of inflammatory responses. Here, we studied the role of TNF-α signaling in latent virus reactivation in p55-knock out (KO) mouse model of ocular HSV-1 infection. Read More

    Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.
    Antiviral Res 2017 Nov 4;149:1-6. Epub 2017 Nov 4.
    The University of Alabama at Birmingham, School of Medicine, Birmingham, AL, USA.
    Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV type 1 or 2, including acyclovir-resistant strains, were treated 72 h after infection for 7 days with pritelivir or acyclovir. Both drugs were administered orally twice daily either alone or in combination. Read More

    Detection of cytomegalovirus, herpes virus simplex, and parvovirus b19 in spontaneous abortion placentas.
    J Matern Fetal Neonatal Med 2017 Nov 7:1-8. Epub 2017 Nov 7.
    a Departament of Pediatrics, Faculty of Medicine , Federal University of Minas Gerais , Belo Horizonte , Brasil.
    Objective: This study aims to investigate the presence of Cytomegalovirus (CMV), herpes virus simplex (HSV), and parvovirus B19 (PVB19) in the placental tissue of patients who underwent abortions without an otherwise-defined aetiology.

    Study Design: This cross-sectional study was conducted in a high-risk obstetric maternity facility at a University Hospital in Belo Horizonte, Brazil, from January 2013 to December 2015. We included placenta samples obtained from spontaneous abortions of unknown aetiology. Read More

    School Support as Structural HIV Prevention for Adolescent Orphans in Western Kenya.
    J Adolesc Health 2017 Oct 26. Epub 2017 Oct 26.
    The Pacific Institute for Research and Evaluation, Chapel Hill, North Carolina.
    Purpose: Using a clustered randomized controlled trial design, we evaluated whether support to keep Kenyan orphaned adolescents in school reduces the risk of HIV infection.

    Methods: Participants included 835 orphaned boys and girls in grades 7 and 8 (mean age at the baseline = 15 years) in western Kenya. Primary schools (N = 26) were randomized to the study condition. Read More

    Expression and characterization of the soluble form of recombinant mature HSV-2 glycoprotein G for use in anti-HSV-2 IgG serodiagnostic immunoassay.
    J Virol Methods 2017 Oct 28. Epub 2017 Oct 28.
    Theranos, Inc.,1701 Page Mill Road, Palo Alto, CA, 94304, USA. Electronic address:
    Herpes simplex virus type-2 (HSV-2) specific glycoprotein G (gG-2) is widely used as the antigen of choice for serodiagnosis of HSV-2. In order to develop an ELISA for serodetection of HSV-2 IgG in patient sera, the soluble form of the mature gG-2 antigen (mgG-2), gG283-649, was expressed using a baculovirus expression system. gG283-649 contains the complete extracellular domain of mgG-2 including the C-terminal region, which despite homology to gG-1, does not cross-react with HSV-1 antibodies present in HSV-1 positive patient sera. Read More

    Houttuynoid M, an Anti-HSV Active Houttuynoid from Houttuynia cordata Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core.
    J Nat Prod 2017 Nov 3;80(11):3010-3013. Epub 2017 Nov 3.
    Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University , Guangzhou 510632, People's Republic of China.
    Houttuynoid M (1), a new houttuynoid, and the related known compound houttuynoid A (2) were isolated from Houttuynia cordata. Their structures were defined using NMR data analysis, HR-MS(n) experiment, and chemical derivatization. Houttuynoid M is the first example of a houttuynoid with a bis-houttuynin chain tethered to a flavonoid core. Read More

    Low intrathecal antibody production despite high seroprevalence of Epstein-Barr virus in multiple sclerosis: a review of the literature.
    J Neurol 2017 Nov 2. Epub 2017 Nov 2.
    Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
    Background: Patients with multiple sclerosis (MS) frequently have an intrathecal production of antibodies to different common viruses, which can be detected by elevated antiviral antibody indices (AIs). There is a strong and consistent association of MS and Epstein-Barr virus (EBV) infection.

    Objective: To systematically compare the frequencies of intrathecal antibody production to EBV, measles virus, rubella virus, varicella zoster virus (VZV) and herpes simplex virus (HSV) in patients with MS. Read More

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