50,621 results match your criteria Herpes Simplex


Herpetic Keratouveitis following Intravitreal Ranibizumab Injection in a Case with Diabetic Macular Edema.

Ocul Immunol Inflamm 2020 Jul 13:1-3. Epub 2020 Jul 13.

Department of Ophthalmology, Dokuz Eylul University School of Medicine , Izmir, Turkey.

Purpose: The purpose of this study is to report a case of herpetic keratouveitis that developed soon after intravitreal ranibizumab injection.

Case Report: A 54-year-old man with bilateral proliferative diabetic retinopathy and severe macular edema received intravitreal ranibizumab injections in both eyes within 3 days interval. One week after the injection, patient presented with acute vision loss in his right eye. Read More

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http://dx.doi.org/10.1080/09273948.2020.1767793DOI Listing

Design and Rationale for First-In-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors.

Hum Gene Ther 2020 Jul 12. Epub 2020 Jul 12.

The University of Alabama at Birmingham Department of Pediatrics, 135137, Birmingham, Alabama, United States;

Brain tumors represent the most common pediatric solid neoplasms and leading cause of childhood cancer-related morbidity and mortality. While most adult brain tumors are supratentorial and arise in the cerebrum, the majority of pediatric brain tumors are infratentorial and arise in the posterior fossa, specifically the cerebellum. Outcomes from malignant cerebellar tumors are unacceptable despite aggressive treatments (surgery, radiation, and/or chemotherapy) that are harmful to the developing brain. Read More

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http://dx.doi.org/10.1089/hum.2020.101DOI Listing

Mapping of the excitatory, inhibitory, and modulatory afferent projections to the anatomically defined active expiratory oscillator in adult male rats.

J Comp Neurol 2020 Jul 12. Epub 2020 Jul 12.

Department of Physiology Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

The lateral parafacial region (pF ; which encompasses the parafacial respiratory group, pFRG) is a conditional oscillator that drives active expiration during periods of high respiratory demand, and increases ventilation through the recruitment of expiratory muscles. The pF activity is highly modulated, and systematic analysis of its afferent projections is required to understand its connectivity and modulatory control. We combined a viral retrograde tracing approach to map direct brainstem projections to the putative location of pF , with RNAScope and immunofluorescence to identify the neurochemical phenotype of the projecting neurons. Read More

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http://dx.doi.org/10.1002/cne.24984DOI Listing

Indian National Association for the Study of the Liver Consensus Statement on Acute Liver Failure (Part 1): Epidemiology, Pathogenesis, Presentation and Prognosis.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):339-376. Epub 2020 Apr 28.

Institute of Liver & Digestive Diseases and Head of Hepatology & Liver Transplant (Medicine), BLK Super Speciality Hospital, Delhi, India.

Acute liver failure (ALF) is an infrequent, unpredictable, potentially fatal complication of acute liver injury (ALI) consequent to varied etiologies. Etiologies of ALF as reported in the literature have regional differences, which affects the clinical presentation and natural course. In this part of the consensus article designed to reflect the clinical practices in India, disease burden, epidemiology, clinical presentation, monitoring, and prognostication have been discussed. Read More

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http://dx.doi.org/10.1016/j.jceh.2020.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335721PMC

A 72-Year-Old Woman With Respiratory Failure and Bilateral Ground-Glass Opacities.

Chest 2020 Jul 2;158(1):e41-e45. Epub 2020 Jul 2.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.

A 72-year-old woman with diabetes mellitus was admitted to our hospital because of dyspnea on exertion. Sputum cytologic evaluation revealed intranuclear inclusion bodies in the cells; we therefore considered viral pneumonia and performed a bronchoscopy. The bronchial washing fluid was positive for immunoperoxidase staining of herpes simplex virus type 1 (HSV1) and HSV1 polymerase chain reaction. Read More

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http://dx.doi.org/10.1016/j.chest.2019.11.054DOI Listing

Synthesis of antiviral perfluoroalkyl derivatives of teicoplanin and vancomycin.

ChemMedChem 2020 Jul 11. Epub 2020 Jul 11.

Debreceni Egyetem, Pharmaceutical Chemistry, HUNGARY.

The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Here, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides, to produce selective antiviral agents without membrane-disrupting activity. Read More

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http://dx.doi.org/10.1002/cmdc.202000260DOI Listing

Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES).

Biomed J 2020 May 29. Epub 2020 May 29.

Primary Immunodeficiency Care and Research (PICAR) Institute, Chang Gung Memorial Hospital, at Linkou, Taoyuan, Taiwan; Department of Pediatrics, New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital, at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Defective human TLR3 signaling causes recurrent and refractory herpes simplex encephalitis/encephalopathy. Children with febrile infection-related epilepsy syndrome with refractory seizures may have defective TLR responses.

Methods: Children with febrile infection-related epilepsy syndrome were enrolled in this study to evaluate TLR1-9 responses (IL-6, IL-8, IL-12p40, INF-α, INF-γ, and TNF-α) in their peripheral blood mononuclear cells (PBMCs) and monocyte-derived dendritic cells (MDDCs), compared to those with febrile seizures and non-refractory epilepsy with/without underlying encephalitis/encephalopathy. Read More

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http://dx.doi.org/10.1016/j.bj.2020.05.007DOI Listing

Novel transcription regulatory sequences and factors of the immune evasion protein ICP47 (US12) of herpes simplex viruses.

Virol J 2020 Jul 10;17(1):101. Epub 2020 Jul 10.

Laboratory of Oncology, School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, 434023, Hubei, China.

Background: Herpes simplex virus (HSV) can cause encephalitis. Its infected cell polypeptide 47 (ICP47), encoded by immediate-early gene US12, promotes immune escape. ICP47 was modified in the clinically approved oncolytic HSV (oHSV) T-Vec. Read More

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http://dx.doi.org/10.1186/s12985-020-01365-3DOI Listing

Epidemiological Impact of Novel Preventive and Therapeutic HSV-2 Vaccination in the United States: Mathematical Modeling Analyses.

Vaccines (Basel) 2020 Jul 8;8(3). Epub 2020 Jul 8.

Infectious Diseases Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, Doha 24144, Qatar.

This study aims to inform herpes simplex virus type 2 (HSV-2) vaccine development, licensure, and implementation by delineating the population-level impact of vaccination. Mathematical models were constructed to describe the transmission dynamics in presence of prophylactic or therapeutic vaccines assuming 50% efficacy, with application to the United States. Catch-up prophylactic vaccination will reduce, by 2050, annual number of new infections by 58%, incidence rate by 60%, seroprevalence by 21%, and avert yearly as much as 350,000 infections. Read More

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http://dx.doi.org/10.3390/vaccines8030366DOI Listing

Severe oral stomatitis due to reactivation of herpes simplex virus type 1 in a methotrexate-treated patient with dermatomyositis.

Immunol Med 2020 Jul 10:1-5. Epub 2020 Jul 10.

Department of Rheumatology, Kawasaki Medical School, Kurashiki, Japan.

We herein report a case of a 79-year-old Japanese woman who developed severe oral stomatitis during methotrexate (MTX) treatment for dermatomyositis. She had been treated with MTX (12 mg/week) and prednisolone (5 mg/day) for dermatomyositis for 4 years. She developed painful stomatitis, fever, and pancytopenia. Read More

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http://dx.doi.org/10.1080/25785826.2020.1787585DOI Listing

Seropositivity for pathogens associated with chronic infections is a risk factor for all-cause mortality in the elderly: findings from the Memory and Morbidity in Augsburg Elderly (MEMO) Study.

Geroscience 2020 Jul 9. Epub 2020 Jul 9.

Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.

Immunostimulation by chronic infection has been linked to an increased risk for different non-communicable diseases, which in turn are leading causes of death in high- and middle-income countries. Thus, we investigated if a positive serostatus for pathogens responsible for common chronic infections is individually or synergistically related to reduced overall survival in community dwelling elderly. We used data of 365 individuals from the German MEMO (Memory and Morbidity in Augsburg Elderly) cohort study with a median age of 73 years at baseline and a median follow-up of 14 years. Read More

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http://dx.doi.org/10.1007/s11357-020-00216-xDOI Listing

Development of vaccines against the sexually transmitted infections gonorrhoea, syphilis, Chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus.

Ther Adv Vaccines Immunother 2020 27;8:2515135520923887. Epub 2020 Jun 27.

FEO - Faculty Education Office (Medicine), Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London, SW7 2AZ, UK.

The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. The current status of vaccine development for these infections will be explored in this review. The general principles for success include the need for prevention of latency, persistence and repeat infections. Read More

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http://dx.doi.org/10.1177/2515135520923887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325543PMC

Meta-analytic approach for transcriptome profiling of herpes simplex virus type 1.

Sci Data 2020 Jul 9;7(1):223. Epub 2020 Jul 9.

Department of Medical Biology, Faculty of Medicine, University of Szeged, Somogyi B. u. 4., 6720, Szeged, Hungary.

In this meta-analysis, we re-analysed and compared herpes simplex virus type 1 transcriptomic data generated by eight studies using various short- and long-read sequencing techniques and different library preparation methods. We identified a large number of novel mRNAs, non-coding RNAs and transcript isoforms, and validated many previously published transcripts. Here, we present the most complete HSV-1 transcriptome to date. Read More

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http://dx.doi.org/10.1038/s41597-020-0558-8DOI Listing

Hsv-1 Endocytic Entry into a Human Oligodendrocytic Cell Line is Mediated by Clathrin and Dynamin but Not Caveolin.

Viruses 2020 Jul 7;12(7). Epub 2020 Jul 7.

Departamento de Biología Molecular, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.

Endocytosis is a pathway used by viruses to enter cells that can be classified based on the proteins involved, such as dynamin, clathrin or caveolin. Although the entry of herpes simplex type 1 (HSV-1) by endocytosis has been documented in different cell types, its dependence on clathrin has not been described whereas its dependence on dynamin has been shown according to the cell line used. The present work shows how clathrin-mediated endocytosis (CME) is one way that HSV-1 infects the human oligodendroglial (HOG) cell line. Read More

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http://dx.doi.org/10.3390/v12070734DOI Listing

Painful proctitis with the mixed infection due to Herpes Simplex Virus type 1, type 2 and Chlamydia trachomatis.

Int J Infect Dis 2020 Jul 6. Epub 2020 Jul 6.

Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.ijid.2020.07.002DOI Listing

A case of herpes simplex 2 encephalitis with an unusual radiographic manifestation.

IDCases 2020 22;21:e00884. Epub 2020 Jun 22.

Department of Medicine, St. Elizabeth's Medical Center, Boston, MA, USA.

Herpes Simplex Virus (HSV) continues to be an important pathogen inflicting encephalitis in adults and children globally that entails high morbidity and mortality. Prompt diagnosis and treatment are the keys to minimize potential sequelae of the disease. Although HSV encephalitis-1(HSVE-1) is well recognized for its radiographic manifestation of temporal lobe involvement owing to its pathogenesis, radiographic features of HSVE-2 are less uniform. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334455PMC

Longitudinal transcriptomic characterization of viral genes in HSV-1 infected tree shrew trigeminal ganglia.

Virol J 2020 Jul 8;17(1):95. Epub 2020 Jul 8.

Key Laboratory of Animal Models and Human Disease Mechanism of the Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, 650223, Yunnan, China.

Background: Following acute infection, Herpes Simplex virus-1 (HSV-1) establishes lifelong latency and recurrent reactivation in the sensory neurons of trigeminal ganglia (TG). Infected tree shrew differs from mouse and show characteristics similar to human infection. A detailed transcriptomic analysis of the tree shrew model could provide mechanistic insights into HSV-1 infection in humans. Read More

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http://dx.doi.org/10.1186/s12985-020-01344-8DOI Listing

Frontline Science: AMPK regulates metabolic reprogramming necessary for interferon production in human plasmacytoid dendritic cells.

J Leukoc Biol 2020 Jul 8. Epub 2020 Jul 8.

Department of Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Plasmacytoid dendritic cells (pDCs) play a crucial role in innate viral immunity as the most potent producers of type I interferons (IFN) in the human body. However, the metabolic regulation of IFN production in such vast quantity remains poorly understood. In this study, AMP-activated protein kinase (AMPK) is strongly implicated as a driver of metabolic reprogramming that the authors and others have observed in pDCs after activation via TLR7/9. Read More

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http://dx.doi.org/10.1002/JLB.3HI0220-130DOI Listing

as an emerging opportunistic pathogen: First case of superinfection in herpetic keratitis.

Am J Ophthalmol Case Rep 2020 Sep 25;19:100791. Epub 2020 Jun 25.

Department of Microbiology and Immunology, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium.

Purpose: Only recently was described as a new genus in the family of fungi containing two species, and . Until now, keratitis was associated with contact lens wear and ocular trauma. We present the first case of keratomycosis presenting as a superinfection in herpetic keratitis. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327197PMC
September 2020

Palate herpes simplex virus infection.

Pan Afr Med J 2020 15;35:123. Epub 2020 Apr 15.

Private Dental Practice, Cagliari, Italy.

Psoriasis only affecting the genital area occurs in 2-5% of subjects with psoriasis. This condition is a frequent reason for consultation with a specialist in men's genital mucosa, since it accounts for 24% of the reasons for consultation. The gland of circumcised subjects is usually finely squamous and non-squamous in non-circumcised subjects, based on preputial moisture. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.123.18748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320786PMC

Pathophysiology of paraneoplastic and autoimmune encephalitis: genes, infections, and checkpoint inhibitors.

Ther Adv Neurol Disord 2020 24;13:1756286420932797. Epub 2020 Jun 24.

Centre de Référence National pour les Syndromes Neurologiques Paranéoplasiques, Hôpital Neurologique, 59 Boulevard Pinel, Bron Cedex, 69677, France.

Paraneoplastic neurological syndromes (PNSs) are rare complications of systemic cancers that can affect all parts of the central and/or peripheral nervous system. A body of experimental and clinical data has demonstrated that the pathogenesis of PNSs is immune-mediated. Nevertheless, the mechanisms leading to immune tolerance breakdown in these conditions remain to be elucidated. Read More

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http://dx.doi.org/10.1177/1756286420932797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318829PMC

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.

Nat Commun 2020 Jul 7;11(1):3382. Epub 2020 Jul 7.

Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.

The Stimulator of Interferon Genes (STING) pathway initiates potent immune responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C-terminal tail (CTT) of STING is phosphorylated, leading to induction of type I interferons (IFNs). Additionally, evolutionary conserved responses such as autophagy also occur downstream of STING, but their relative importance during in vivo infections remains unclear. Read More

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http://dx.doi.org/10.1038/s41467-020-17156-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341812PMC

[Clinical featuers of adult patients with post-viral-encephalitis autoimmune encephalitis].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1933-1936

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To explore the clinical features of post-viral-encephalitis autoimmune encephalitis (PVEAE). Ten cases of PVEAE, who were hospitalized in the Neurology Department of Peking Union Medical College Hospital (PUMCH) between November 2014 and October 2019, were retrospectively reviewed. Clinical manifestation, immunology, neuroradiology, treatment and outcomes were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200115-00095DOI Listing

Effect of antiviral therapy on the outcome of mechanically ventilated patients with herpes simplex virus type 1 in bronchoalveolar lavage fluid: a retrospective cohort study.

Chest 2020 Jul 3. Epub 2020 Jul 3.

Institute for Infectious Diseases and Infection Control, Jena University Hospital, Jena, Germany. Electronic address:

Background: Herpes simplex virus type 1 (HSV-1) is frequently detected in the bronchoalveolar lavage fluid (BAL) of mechanically ventilated patients.

Research Question: The aim of the study was to investigate whether antiviral therapy is associated with improved overall survival within 30 days.

Study Design: Retrospective cohort study in 4 intensive care units (ICUs) between 01/2011 and 12/2017. Read More

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http://dx.doi.org/10.1016/j.chest.2020.06.056DOI Listing

Utility of Neonatal Ophthalmologic Examination for Detection of Infectious Etiologies for Symmetric Intrauterine Growth Restriction.

J Pediatr 2020 Jul 3. Epub 2020 Jul 3.

Wills Eye Hospital, Philadelphia, PA; Cooper University Hospital, Camden, NJ.

Objective: To determine the utility of ophthalmologic examination as part of evaluation for infection in infants with intrauterine growth restriction (IUGR).

Study Design: This is a single-institution retrospective chart review of neonates diagnosed with symmetric IUGR or small for gestational age (SGA) who underwent complete ophthalmologic consultation to assess for intraocular findings suggestive of congenital infection. Data collected included other factors that may cause IUGR, findings of the general and ophthalmologic examination, and results of investigation for intrauterine infection. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.07.003DOI Listing

Antiviral activity of algae biosynthesized silver and gold nanoparticles against Herps Simplex (HSV-1) virus in vitro using cell-line culture technique.

Int J Environ Health Res 2020 Jul 6:1-12. Epub 2020 Jul 6.

Department of Botany and Microbiology, Faculty of Science, Menoufia University , Menoufia, Egypt.

As therapeutic antiviral agents, biological nanoparticles can fight the drug-resistant types of viruses helping the antiviral drug development. In this study, two blue-green algal strains; sp. and were used, mediated by green AgO|AgO-NPs and Au-NPs, respectively. Read More

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http://dx.doi.org/10.1080/09603123.2020.1789946DOI Listing

Structural, physical characteristics and biological activities assessment of scleroglucan from a local strain Athelia rolfsii TEMG.

Int J Biol Macromol 2020 Jul 2. Epub 2020 Jul 2.

Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Div., National Research Centre, Dokki, Cairo, Egypt. Electronic address:

Athelia rolfsii TEMG (MH 236106) an exopolysaccharide (EPS) producing fungal strain was isolated and identified. Extraction, purification, characterization, antimicrobial, antioxidant, antiviral and antitumor activities of the polysaccharide were investigated. It characterized as a homopolysaccharide of glucose with a molecular weight of 345. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.272DOI Listing

The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.

RNA Biol 2020 Jul 13:1-15. Epub 2020 Jul 13.

Institute of Molecular Biology and Biotechnology (IMBB), the University of Lahore (UOL) , Lahore, Pakistan.

Circular RNAs (circRNAs) are ubiquitously expressed, covalently closed rings, produced by pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity endows 3'-5'-linked circRNAs with stability and resistance to exonucleolytic degradation which raises the question whether circRNAs may be relevant as potential therapeutic targets or agents. High stability in biological systems is the most remarkable property and a major criterion for why circRNAs could be exploited for a range of RNA-centred medical applications. Read More

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http://dx.doi.org/10.1080/15476286.2020.1790198DOI Listing
July 2020
4.974 Impact Factor

Dermatological Toxicities of Bruton's Tyrosine Kinase Inhibitors.

Am J Clin Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Haematology Department, Institut Universitaire du Cancer Toulouse Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France.

The development of Bruton's tyrosine kinase (BTK) inhibitors represents a major breakthrough in the treatment of chronic lymphocytic leukemia and other B cell malignancies. The first-generation inhibitor ibrutinib works by covalent irreversible binding to BTK, a non-receptor tyrosine kinase of the TEC (transient erythroblastopenia of childhood) family that plays a critical role in the B-cell receptor signaling pathway. It also induces an 'off-target' inhibition of a range of other kinases including (but not limited to) epidermal growth factor receptor (EGFR), SRC, and other kinases of the TEC family (interleukin-2-inducible T-cell kinase [ITK], Tec, BMX). Read More

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http://dx.doi.org/10.1007/s40257-020-00535-xDOI Listing

Third time's a charm: diagnosis of herpes simplex encephalitis after two negative polymerase chain reaction results.

Heliyon 2020 Jun 23;6(6):e04247. Epub 2020 Jun 23.

Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Introduction: Polymerase chain reaction (PCR) testing of cerebrospinal fluid (CSF) is a sensitive and specific method in diagnosing herpes simplex virus (HSV) encephalitis. However there are increasing reports of false negative HSV PCR.

Case Description: We present a patient in the 9 decade of life with abnormal behavior and focal seizures with MRI showing a right temporal T2 hyperintense non-enhancing lesion with electrographic evidence of right lateralized periodic discharges. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322049PMC

Cytotoxicity study of the interleukin-12-expressing recombinant Newcastle disease virus strain, rAF-IL12, towards CT26 colon cancer cells in vitro and in vivo.

Cancer Cell Int 2020 29;20:278. Epub 2020 Jun 29.

Institute of Bioscience, Universiti Putra Malaysia, Serdang, Selangor Darul Ehsan 43400 Malaysia.

Background: Oncolytic viruses have emerged as an alternative therapeutic modality for cancer as they can replicate specifically in tumour cells and induce toxic effects leading to apoptosis. Despite the great potentials and promising results shown in multiple studies, it appears that their efficacy is still moderate and deemed as not sufficient in clinical studies. In addressing this issue, genetic/molecular engineering approach has paved its way to improve the therapeutic efficacy as observed in the case of herpes simplex virus (HSV) expressing granulocyte-macrophage colony-stimulating factor (GM-CSF). Read More

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http://dx.doi.org/10.1186/s12935-020-01372-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325054PMC

New Mechanism of Acyclovir Resistance of Herpes Simplex Virus 1, Which Has an Amber UAG Codon Between the First and Second AUG Initiation Codons.

Jpn J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Department of Virology 1, National Institute of Infectious Diseases, Japan.

The morphological changes in structure of HSV-1 viral thymidine kinase (vTK) polypeptide usually leads to conferring acyclovir (ACV)-resistance. HSV-1 I4-2, in which an amber UAG stop codon is present at the 8th position between the 1st initiation AUG codon (1st position) and the 2nd initiation AUG codon (46th position) of HSV-1 vTK gene, showed sensitivity to acyclovir (ACV), whereas HSV-1 KG111, in which an amber codon was artificially inserted at the 44th position, showed resistance to ACV at 39˚C. The mechanism for the difference in the sensitivity profiles was elucidated. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.313DOI Listing

Phospho-regulation of a conserved herpesvirus tegument protein by a virally-encoded protein kinase in viral pathogenicity and potential linkage between its evolution and viral phylogeny.

J Virol 2020 Jul 1. Epub 2020 Jul 1.

Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan

Us3 proteins of herpes simplex virus 1 (HSV-1) and HSV-2 are multi-functional serine-threonine protein kinases. Here, we identified an HSV-2 tegument protein UL7 as a novel physiological substrate of HSV-2 Us3. Mutations in HSV-2 UL7, which precluded Us3 phosphorylation of the viral protein, significantly reduced mortality, viral replication in the vagina, and development of vaginal disease in mice following vaginal infection. Read More

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http://dx.doi.org/10.1128/JVI.01055-20DOI Listing

Reprogramming of the Antibacterial Drug Vancomycin Results in Potent Antiviral Agents Devoid of Antibacterial Activity.

Pharmaceuticals (Basel) 2020 Jun 29;13(7). Epub 2020 Jun 29.

Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary.

Influenza A and B viruses are a global threat to human health and increasing resistance to the existing antiviral drugs necessitates new concepts to expand the therapeutic options. Glycopeptide derivatives have emerged as a promising new class of antiviral agents. To avoid potential antibiotic resistance, these antiviral glycopeptides are preferably devoid of antibiotic activity. Read More

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http://dx.doi.org/10.3390/ph13070139DOI Listing

Multiple Herpes Simplex Virus-1 (HSV-1) Reactivations Induce Protein Oxidative Damage in Mouse Brain: Novel Mechanisms for Alzheimer's Disease Progression.

Microorganisms 2020 Jun 29;8(7). Epub 2020 Jun 29.

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00185 Rome, Italy.

Compelling evidence supports the role of oxidative stress in Alzheimer's disease (AD) pathophysiology. Interestingly, Herpes simplex virus-1 (HSV-1), a neurotropic virus that establishes a lifelong latent infection in the trigeminal ganglion followed by periodic reactivations, has been reportedly linked both to AD and to oxidative stress conditions. Herein, we analyzed, through biochemical and redox proteomic approaches, the mouse model of recurrent HSV-1 infection we previously set up, to investigate whether multiple virus reactivations induced oxidative stress in the mouse brain and affected protein function and related intracellular pathways. Read More

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http://dx.doi.org/10.3390/microorganisms8070972DOI Listing

Resolution of Recurrent Oro-facial Herpes Simplex Using a Topical Botanical Gel: A Case Report.

Yale J Biol Med 2020 06 29;93(2):277-281. Epub 2020 Jun 29.

Southwest College of Naturopathic Medicine, The Ric Scalzo Institute for Botanical Research, Tempe, AZ.

Oral herpes labialis, more commonly known as cold sores, are a common encountered viral infection involving herpes simplex virus-1 (HSV-1). Although relatively benign, these lesions can be both unsightly and clinically difficult to manage. Prescription standards of care and over-the-counter agents, such as docosonal, have often shown only limited efficacy in both decreasing lesional pain and reducing duration of lesional symptomology and are not without potential side effects. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309665PMC

A Case of Rhupus with Rowell Syndrome.

Open Access Rheumatol 2020 9;12:91-96. Epub 2020 Jun 9.

Division of Rheumatology, Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Jeddah, Saudi Arabia.

We report a case of 30-year-old female who presented initially with hair loss, photosensitive malar rash, morning stiffness and synovitis. She was diagnosed with Rhupus syndrome based on clinical and laboratory findings. Few months after starting hydroxychloroquine, esomeprazole and azathioprine, and failing methotrexate (because of erosive pill-induced esophagitis), she presented with generalized maculopapular dusky reddish rash in her body, back and extremities. Read More

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http://dx.doi.org/10.2147/OARRR.S255790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293421PMC

Intratonsillar Detection of 27 Distinct Viruses: A Cross-Sectional Study.

J Med Virol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.

Background: Palatine tonsils have been observed to harbor several distinct respiratory and herpes viruses in separate studies. In this study the presence of these viruses in palatine tonsils was comprehensively studied in both children and adults.

Methods: A cross-sectional analysis of 181 patients (median age 22 years, range 2. Read More

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http://dx.doi.org/10.1002/jmv.26245DOI Listing

High-efficiency nonhomologous insertion of a foreign gene into the herpes simplex virus genome.

J Gen Virol 2020 Jun 30. Epub 2020 Jun 30.

Yunnan Key Laboratory of Vaccine Research and Development of Severe Infectious Disease, Kunming, 650118, Yunnan, PR China.

Efficient, accurate and convenient foreign-gene insertion strategies are crucial for the high-throughput and rapid construction of large DNA viral vectors, but relatively inefficient and labour-intensive methods have limited the application of recombinant viruses. In this study, we applied the nonhomologous insertion (NHI) strategy, which is based on the nonhomologous end joining (NHEJ) repair pathway. Compared to the currently used homologous recombination (HR) strategy, we obtained a higher efficiency of foreign-gene insertion into the herpes simplex virus (HSV) genome that reached 45 % after optimization. Read More

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http://dx.doi.org/10.1099/jgv.0.001451DOI Listing

Central nervous system infections in a tropical area: Influence of emerging and rare infections.

Eur J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Centre Hospitalier Universitaire de la Guadeloupe, Service de Neurologie, Pointe-à-Pitre, Abymes, French West Indies, France.

Background And Purpose: The frequency of infectious encephalitis and the distribution of causative pathogens in the tropical areas are poorly known and may be influenced by emerging and rare infections. The aim was to characterize a large series of acute infectious encephalitis and myelitis in immunocompetent patients from the Caribbean island of Guadeloupe identifying clinical, biological and radiological features according to pathogens.

Methods: Using a hospital database, we retrospectively collected detailed information on a comprehensive series of immunocompetent patients with acute infectious myelitis and encephalitis over the 2012-2018 period. Read More

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http://dx.doi.org/10.1111/ene.14422DOI Listing

Prevalence of toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH) infections among women attending the antenatal care clinic, maternity hospital in Abha, Southwestern Saudi Arabia.

Saudi Med J 2020 Jul;41(7):757-762

Department of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. E-mail.

Objectives: To investigate the presence of toxoplasmosis, rubella, cytomegalovirus, and herpes (TORCH) infections in women attending at the antenatal care clinic in Abha, Kingdom of Saudi Arabia (KSA). Methods: A total of 190 blood samples were collected from Abha maternity hospital in Aseer region, KSA, from February 2018 to May 2019 and screened with the TORCH panel (toxoplasmagondii [IgG/IgM], cytomegalovirus [CMV] [IgG/IgM], rubella [IgG/IgM], and herpes simplex type 1 and 2 [IgG/IgM]).

Results: The mean age was 31. Read More

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http://dx.doi.org/10.15537/smj.2020.7.25121DOI Listing
July 2020
0.554 Impact Factor

In Vitro and In Vivo Activity, Tolerability and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus-2 Genital Infection.

Antimicrob Agents Chemother 2020 Jun 29. Epub 2020 Jun 29.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612

Herpes simplex virus type 2 (HSV-2) causes recurrent lesions in the ano-genital area that may be transmitted through sexual encounters. Nucleoside analogs such as acyclovir (ACV) are currently prescribed clinically to curb this infection. But in some cases, reduced efficacy has been observed due to the emergence of resistance against these drugs. Read More

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http://dx.doi.org/10.1128/AAC.00245-20DOI Listing
June 2020
4.476 Impact Factor

L.: A Phytochemical and Pharmacological Overview.

Molecules 2020 Jun 24;25(12). Epub 2020 Jun 24.

Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia.

is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. Read More

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http://dx.doi.org/10.3390/molecules25122898DOI Listing

Mouse Footpad Inoculation Model to Study Viral-Induced Neuroinflammatory Responses.

J Vis Exp 2020 Jun 14(160). Epub 2020 Jun 14.

Department of Molecular Biology, Princeton University.

This protocol describes a footpad inoculation model used to study the initiation and development of neuroinflammatory responses during alphaherpesvirus infection in mice. As alphaherpesviruses are main invaders of the peripheral nervous system (PNS), this model is suitable to characterize the kinetics of viral replication, its spread from the PNS to CNS, and associated neuroinflammatory responses. The footpad inoculation model allows virus particles to spread from a primary infection site in the footpad epidermis to sensory and sympathetic nerve fibers that innervate the epidermis, sweat glands, and dermis. Read More

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http://dx.doi.org/10.3791/61121DOI Listing

Intraventricular hemorrhage as clinical presentation of herpes simplex virus encephalitis. A case report and review of the literature.

Int J Neurosci 2020 Jul 7:1-6. Epub 2020 Jul 7.

Stroke Unit, Cova da Beira University Hospital, Covilhã, Portugal.

Objective: Herpes simplex virus encephalitis (HSVE) represents the most common cause of sporadic encephalitis in humans. The development of intracerebral hematomas is rare and late during the course of HSVE. To report a case of a patient with HSVE who initially presented a diffuse intracranial hemorrhage with predominant intraventricular bleeding. Read More

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http://dx.doi.org/10.1080/00207454.2020.1787409DOI Listing

Sofosbuvir Thio-analogues: Synthesis and Antiviral Evaluation of the First Novel Pyridine- and Pyrimidine-Based Thioglycoside Phosphoramidates.

ACS Omega 2020 Jun 9;5(24):14645-14655. Epub 2020 Jun 9.

Chemistry Department, Faculty of Science, Helwan University, Helwan, Cairo 11795, Egypt.

The synthesis and antiviral screening of the first reported series of pyridine- and pyrimidine-based thioglycoside phosphoramidates are herein reported. They were prepared through two synthetic steps: The first step is via coupling of mercapto-derivatized heterocyclic bases with the appropriate α-bromo per-acetylated sugars. The second one is the hydrolysis of the acetate esters under basic conditions that were consequently conjugated with the phosphoramidating reagent to afford the desired thioglycoside protides. Read More

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http://dx.doi.org/10.1021/acsomega.0c01364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315579PMC

Antiviral activity of berberine.

Arch Virol 2020 Jun 28. Epub 2020 Jun 28.

Molecular Virology Research Unit, Institute of Experimental Biology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.

Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and antiviral activity. BBR targets different steps in the viral life cycle and is thus a good candidate for use in novel antiviral drugs and therapies. Read More

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http://dx.doi.org/10.1007/s00705-020-04706-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320912PMC

The association between exposure to herpes simplex virus type 1 (HSV-1) and cognitive functioning in schizophrenia: A meta-analysis.

Psychiatry Res 2020 Jun 21;291:113157. Epub 2020 Jun 21.

Johns Hopkins School of Medicine, 600 North Wolfe St., Baltimore, MD 21287.

Cognitive deficits are characteristic of schizophrenia but their etiology is not understood. Previous studies show an association between viral exposures and cognitive impairment. This meta-analysis was undertaken to determine the relationship of herpes simplex virus type 1 (HSV-1) exposure and cognitive functioning in schizophrenia. Read More

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http://dx.doi.org/10.1016/j.psychres.2020.113157DOI Listing