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    Structure of the herpes simplex virus portal-vertex.
    PLoS Biol 2018 Jun 20;16(6):e2006191. Epub 2018 Jun 20.
    Medical Research Council, University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
    Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus. Herpes virions contain a large icosahedral capsid that has a portal at a unique 5-fold vertex, similar to that seen in the tailed bacteriophages. The portal is a molecular motor through which the viral genome enters the capsid during virion morphogenesis. Read More

    Hepatitis caused by herpes group viruses: A review.
    J Dig Dis 2018 Jun 20. Epub 2018 Jun 20.
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA.
    Herpes virus hepatitis varies in presentation, ranging from asymptomatic to acute liver failure, in both immunocompetent and immunocompromised individuals. Hepatitis caused by herpes viridae family is uncommon and usually results in mild diseases. It is also often self-limited, although in certain populations especially immunosuppressive patients it can cause severe infections, leading to acute to fulminant hepatic failure. Read More

    HIV incidence is rapidly increasing with age among young men who have sex with men in China: a multicentre cross-sectional survey.
    HIV Med 2018 Jun 19. Epub 2018 Jun 19.
    Department of Laboratory Medicine, Key Laboratory of AIDS Immunology of National Health and Family Planning Commission, The First Affiliated Hospital, China Medical University, Shenyang, China.
    Objectives: The HIV epidemic is worsening among men who have sex with men (MSM) in China, especially among those who are younger than 25 years old [younger MSM (YMSM)]. The aim of the study was to compare the prevalences of HIV incidence and recent HIV infection as well as factors associated with recent HIV infection in YMSM and older MSM (OMSM).

    Methods: A multicentre cross-sectional survey was conducted among 4496 MSM recruited from seven Chinese cities. Read More

    Design, formulation, and evaluation of a herbal gel contains melissa, sumac, licorice, rosemary, and geranium for treatment of recurrent labial herpes infections.
    Dent Res J (Isfahan) 2018 May-Jun;15(3):191-200
    Department of Pharmaceutics, Novel Drug Delivery Systems Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: The herpes simplex virus is a human pathogen which can cause skin or mucous membrane infections. Melissa, sumac, licorice, rosemary, and geranium have antimicrobial, antiviral, anti-inflammatory, and local analgesic effect. Shortening recovery period of recurrent herpes labialis and control of viral protein formation are the other effects of these herbs. Read More

    Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor.
    Front Pharmacol 2018 5;9:592. Epub 2018 Jun 5.
    Division of Internal Medicine, Laboratory of Neuroimmunology, Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
    We recently identified the balance between the level of G protein coupled receptor kinase 2 (GRK2) and Epac1 in nociceptors as a key factor in the transition from acute to chronic pain that occurs in mice 'primed' by an inflammatory stimulus. Here, we examined the contribution of GRK2 and Epac-signaling to growth factor-induced hyperalgesic priming. Mice were primed by intraplantar injection with glial cell-derived neurotrophic factor (GDNF). Read More

    Surveillance of microcephaly and selected brain anomalies in Argentina: Relationship with Zika virus and other congenital infections.
    Birth Defects Res 2018 Jun 19. Epub 2018 Jun 19.
    National Network of Congenital Abnormalities Argentina (RENAC) under the National Center of Medical Genetics (CENAGEM), Buenos Aires City, Argentina.
    Background: Zika virus (ZIKV) vertical transmission may lead to microcephaly and other congenital anomalies. In March and April 2016, the first outbreak of ZIKV occurred in Argentina. The objective was to describe the surveillance of newborns with microcephaly and other selected brain anomalies in Argentina, and evaluation different etiologies. Read More

    Genome-Wide Surveillance of Genital Herpes Simplex Virus Type 1 From Multiple Anatomic Sites Over Time.
    J Infect Dis 2018 Jun 18. Epub 2018 Jun 18.
    Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park.
    Here we present genomic and in vitro analyses of temporally separated episodes of herpes simplex virus type 1 (HSV-1) shedding by an HSV-1-seropositive and human immunodeficiency virus (HIV)/HSV-2-seronegative individual who has frequent recurrences of genital HSV-1. Using oligonucleotide enrichment, we compared viral genomes from uncultured swab specimens collected on different days and from distinct genital sites. We found that viral genomes from 7 swab specimens and 3 cultured specimens collected over a 4-month period from the same individual were 98. Read More

    Epidemiology and Clinical Outcomes of Viral Central Nervous System Infections.
    Int J Infect Dis 2018 Jun 15. Epub 2018 Jun 15.
    Department of Medicine, Division of Infectious Diseases, Hamad Medical Corporation, Doha, Qatar; Weill Cornell Medical College, New York, NY, USA; Doha, Qatar.
    Background: Central nervous system (CNS) viral infections are an important cause of morbidity and mortality. No data are available regarding their epidemiology in Qatar.

    Design: We retrospectively evaluated all cerebrospinal fluid findings from January 2011-March 2015 at Hamad Medical Corporation. Read More

    Dermatological Manifestations of HIV/AIDS Individuals in Shiraz, South of Iran.
    J Glob Infect Dis 2018 Apr-Jun;10(2):80-83
    Department of Dermatology, Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Introduction: HIV infection remains as a major challenge facing medical sciences in the world today. Mucocutaneous manifestation was first observed in patients with HIV/AIDS in the early 1980s. The aim of this study was to identify various skin manifestations based on making careful clinical observations and performing the necessary tests. Read More

    Antifungal drug ciclopirox olamine reduces HSV-1 replication and disease in mice.
    Antiviral Res 2018 Jun 14. Epub 2018 Jun 14.
    Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, 1100 S. Grand Blvd., St. Louis, Missouri, 63104, USA. Electronic address:
    Herpes simplex virus (HSV)-1 and HSV-2 cause painful blisters and shallow ulcers in exposed skin and mucosae during primary or recurrent infection. In addition, recurrent and potentially blinding HSV-1 infections of the eye afflict nearly half a million persons in the U.S. Read More

    Interferon epsilon in the reproductive tract of healthy and genital herpes simplex virus-infected pregnant women: Results of a pilot study.
    Am J Reprod Immunol 2018 Jun 14:e12995. Epub 2018 Jun 14.
    Department of Epidemiology and Biostatistics, Texas A&M University, College Station, TX, USA.
    Problem: Recently characterized interferon epsilon (IFNe) protects against sexually transmitted infections, including genital herpes simplex virus (HSV), in animal models. There are no reports of IFNe in genital tract secretions of pregnant women, and data on IFNe in non-pregnant women are limited. This pilot study is the first to measure concentrations of IFNe in vaginal and cervical secretions during pregnancy and compare values between healthy and genital HSV-infected women. Read More

    Infection-triggered autoimmunity: The case of herpes simplex virus type 1 and anti-NMDAR antibodies.
    Neurol Neuroimmunol Neuroinflamm 2018 Jul 11;5(4):e471. Epub 2018 Jun 11.
    Neuroimmunology Group (R.C.D.), Kids Neuroscience Centre, Kids Research at the Children's Hospital at Westmead, University of Sydney, Australia; and the Paediatric Neurology and Neurophysiology Unit (M.N.), Department of Women's and Children's Health, University Hospital of Padua, Italy.

    Analytical validation of viral CNS Flow Chip kit for detection of acute meningitis and encephalitis.
    J Virol Methods 2018 Jun 11. Epub 2018 Jun 11.
    Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria de Granada, Avda. Fuerzas Armadas, 2, Granada, 18014, Spain.
    A new molecular assay (Viral CNS Flow Chip kit, Master Diagnóstica, Spain) has been developed for the detection of eight viruses causing acute meningitis and encephalitis, i.e. herpes simplex viruses 1-2, varicella zoster virus, human enterovirus, human parechovirus, Toscana virus, human cytomegalovirus and Epstein Barr virus. Read More

    A case report: asymptomatic esophageal eosinophilia after herpes simplex esophagitis. Controversies in the therapeutic approach.
    Rev Esp Enferm Dig 2018 Jun 14;110. Epub 2018 Jun 14.
    OSI Goierri-altoUrola.
    The coexistence of eosinophilic esophagitis and herpes simplex virus in patients has been published in numerous case reports in the last few years. Both entities can be diagnosed simultaneously or one prior to the other, raising a possible causal relationship. Esophageal eosinophilia is a histological finding, and its underlying cause should be investigated. Read More

    Fulminant Herpes Simplex Virus Type I Encephalitis Despite Maximal Medical Therapy.
    Cureus 2018 Apr 12;10(4):e2467. Epub 2018 Apr 12.
    Neurology, Cleveland Clinic Ohio.
    Herpes simplex-1 virus encephalitis (HSE) is the most commonly recognized cause of sporadic encephalitis in the United States. Historically HSE has been considered extremely detrimental given the associated relentless neurological deterioration secondary to cerebral edema and status epilepticus. With recent advances in antiviral therapeutics in past decades, the majority of complications can be managed effectively although the associated morbidity and mortality still remains high. Read More

    UBXN3B positively regulates STING-mediated antiviral immune responses.
    Nat Commun 2018 Jun 13;9(1):2329. Epub 2018 Jun 13.
    Department of Microbiology and Immunology, New York Medical College, 15 Dana Road, Valhalla, NY, 10595, USA.
    The ubiquitin regulatory X domain-containing proteins (UBXNs) are likely involved in diverse biological processes. Their physiological functions, however, remain largely unknown. Here we present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. Read More

    Regulation of Herpes Simplex Virus 2 Protein Kinase UL13 by Phosphorylation and Its Role in Viral Pathogenesis.
    J Virol 2018 Jun 13. Epub 2018 Jun 13.
    Division of Molecular Virology, Department of Microbiology and Immunology, the Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    UL13 proteins are serine/threonine protein kinases encoded by herpes simplex virus HSV-1 and HSV-2. Although the downstream effects of the HSV protein kinases, mostly those of HSV-1 UL13, have been reported, there is a lack of information on how these viral protein kinases are regulated in HSV-infected cells. In this study, we used a large-scale phosphoproteomic analysis of HSV-2-infected cells to identify a physiological phosphorylation site in HSV-2 UL13 (i. Read More

    Human Asymptomatic Epitope Peptide/CXCL10-Based Prime/Pull Vaccine Induces Herpes Simplex Virus-Specific Gamma Interferon-Positive CD107 CD8 T Cells That Infiltrate the Cornea and Trigeminal Ganglia of Humanized HLA Transgenic Rabbits and Protect against Ocular Herpes Challenge.
    J Virol 2018 Jun 13. Epub 2018 Jun 13.
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, School of Medicine, University of California Irvine, Irvine, California, USA
    Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that infects the cornea causing potentially blinding herpetic disease. A clinical herpes vaccine is still lacking. In the present study, a novel prime/pull vaccine was tested in Human Leukocyte Antigen- (HLA-) transgenic rabbit model of ocular herpes (HLA Tg rabbit). Read More

    Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture.
    mSphere 2018 Jun 13;3(3). Epub 2018 Jun 13.
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
    Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We report the development and validation of a DNA oligonucleotide hybridization panel to recover nearly complete HSV genomes at abundances up to 50,000-fold lower than previously reported. Read More

    Antiviral Drugs Against Alphaherpesvirus.
    Adv Exp Med Biol 2018 ;1045:103-122
    Department of Virology, University of Toyama, Toyama, Japan.
    The discovery of acyclovir and penciclovir has led to the development of a successful systemic therapy for treating herpes simplex virus infection and varicella-zoster virus infection, and the orally available prodrugs, valacyclovir and famciclovir, have improved antiviral treatment compliance. Acyclovir and penciclovir are phosphorylated by viral thymidine kinase and are incorporated into the DNA chain by viral DNA polymerase, resulting in chain termination. Helicase-primase plays an initial step in DNA synthesis to separate the double strand into two single strands (replication fork) and is a new target of antiviral therapy. Read More

    Neurological Disorders Associated with Human Alphaherpesviruses.
    Adv Exp Med Biol 2018 ;1045:85-102
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic fatal encephalitis worldwide, and central nervous system (CNS) involvement is observed in approximately one-third of neonatal HSV infections . In recent years, single-gene inborn errors of innate immunity have been shown to be associated with susceptibility to HSV encephalitis . Temporal lobe abnormalities revealed by magnetic resonance imaging-the most sensitive imaging method for HSV encephalitis-are considered strong evidence for the disease. Read More

    Oncolytic Virotherapy by HSV.
    Adv Exp Med Biol 2018 ;1045:63-84
    Department of Virology, Graduate School of Medicine, Nagoya University, Nagoya, Japan.
    Oncolytic virotherapy is a kind of antitumor therapy using viruses with natural or engineered tumor-selective replication to intentionally infect and kill tumor cells. An early clinical trial has been performed in the 1950s using wild-type and non-engineered in vitro-passaged virus strains and vaccine strains (first generation oncolytic viruses). Because of the advances in biotechnology and virology, the field of virotherapy has rapidly evolved over the past two decades and innovative recombinant selectivity-enhanced viruses (second generation oncolytic viruses). Read More

    Us3 Protein Kinase Encoded by HSV: The Precise Function and Mechanism on Viral Life Cycle.
    Adv Exp Med Biol 2018 ;1045:45-62
    Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
    All members of the Alphaherpesvirinae subfamily encode a serine/threonine kinase, designated Us3, which is not conserved in the other subfamilies. Us3 is a significant virulence factor for herpes simplex virus type 1 (HSV-1), which is one of the best-characterized members of the Alphaherpesvirinae family. Accumulating evidence indicates that HSV-1 Us3 is a multifunctional protein that plays various roles in the viral life cycle by phosphorylating a number of viral and cellular substrates. Read More

    Virus Assembly and Egress of HSV.
    Adv Exp Med Biol 2018 ;1045:23-44
    Department of Pathology, University of Cambridge, Cambridge, UK.
    The assembly and egress of herpes simplex virus (HSV) is a complicated multistage process that involves several different cellular compartments and the activity of many viral and cellular proteins. The process begins in the nucleus, with capsid assembly followed by genome packaging into the preformed capsids. The DNA-filled capsids (nucleocapsids) then exit the nucleus by a process of envelopment at the inner nuclear membrane followed by fusion with the outer nuclear membrane. Read More

    The Role of HSV Glycoproteins in Mediating Cell Entry.
    Adv Exp Med Biol 2018 ;1045:3-21
    Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan.
    The successful entry of herpes simplex virus (HSV) into a cell is a complex process requiring the interaction of several surface viral glycoproteins with host cell receptors. These viral glycoproteins are currently thought to work sequentially to trigger fusogenic activity, but the process is complicated by the fact that each glycoprotein is known to interact with a range of target cell surface receptor molecules. The glycoproteins concerned are gB, gD, and gH/gL, with at least four host cell receptor molecules known to bind to gB and gD alone. Read More

    Multivalent Flexible Nanogels Exhibit Broad-Spectrum Antiviral Activity by Blocking Virus Entry.
    ACS Nano 2018 Jun 19. Epub 2018 Jun 19.
    Institut für Virologie, Robert von Ostertag-Haus, Zentrum für Infektionsmedizin , Freie Universität Berlin , Robert-von-Ostertag-Str. 7-13 , 14163 Berlin , Germany.
    The entry process of viruses into host cells is complex and involves stable but transient multivalent interactions with different cell surface receptors. The initial contact of several viruses begins with attachment to heparan sulfate (HS) proteoglycans on the cell surface, which results in a cascade of events that end up with virus entry. The development of antiviral agents based on multivalent interactions to shield virus particles and block initial interactions with cellular receptors has attracted attention in antiviral research. Read More

    Non-Small-Cell Lung Cancer: Feasibility of Intratumoral Radiofrequency Hyperthermia-enhanced Herpes Simplex Virus Thymidine Kinase Gene Therapy.
    Radiology 2018 Jun 12:172148. Epub 2018 Jun 12.
    From the Image-Guided Bio-Molecular Interventions Research and Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, 850 Republican St, S470, Seattle, WA 98109 (J.J., Q.W., F.Z., F.X., Y.J., J.S., J.G., M.C., Q.L., D.S., X.Y.); Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Department of Radiology, Zhejiang University Lishui Hospital, Lishui, Zhejiang, China (J.J., Q.W., J.H., J.S., M.C., Q.L.); and Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (Y.J., X.Y.).
    Purpose To validate the feasibility and efficacy of intratumoral radiofrequency hyperthermia (RFH)-enhanced herpes simplex virus (HSV) thymidine kinase (TK) and ganciclovir (GCV) (hereafter, HSV-TK/GCV) gene therapy for non-small-cell lung cancer (NSCLC). Materials and Methods This study was performed from November 11, 2015, to April 14, 2017, and included (a) in vitro experiments with human NSCLC cells to establish the proof of principle, (b) in vivo experiments using mice with subcutaneous NSCLC to further demonstrate the principle, and (c) in vivo experiments using rats with orthotopic NSCLC to validate the technical feasibility. Cells, nude mice, and nude rats were randomly divided into four groups (six animals per group): (a) combination therapy (HSV-TK/GCV combined with RFH), (b) RFH, (c) HSV-TK/GCV, and (d) phosphate-buffered saline. Read More

    prediction of cellular gene targets of herpesvirus encoded microRNAs.
    Data Brief 2018 Aug 19;19:249-255. Epub 2018 May 19.
    Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago IL 60612 USA.
    Herpesviruses have evolved to encode multiple microRNAs [viral miRNAs (v-miRs)], a unique feature of this family of double stranded DNA (dsDNA) viruses. However, functional role of these v-miRs in host-pathogen interaction remains poorly studied. In this data, we examined the impact of oral disease associated v-miRs . Read More

    A case with angiographic demonstration of isolated anterior spinal artery occlusion.
    Ideggyogy Sz 2018 Mar;71(3-04):137-139
    Bakirkoy Training and Research Hospital for Psychiatry and Neurological Disorders, Istanbul, Turkey.
    Anterior spinal artery syndrome (ASAS) is a rare syndrome which occurs due to thrombosis of anterior spinal artery (ASA) which supplies anterior two thirds of the spinal cord. A 27-year-old female patient was admitted to emergency clinic with sudden onset neck pain, sensory loss and weakness in proximal upper extremities which occurred at rest. Thrombophilia assessment tests were negative. Read More

    Herpes Viruses and Senile Dementia: First Population Evidence for a Causal Link.
    J Alzheimers Dis 2018 Jun 4. Epub 2018 Jun 4.
    Division of Infection and Pathway Medicine, University of Edinburgh, Little France, Edinburgh, UK.
    Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potential treatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al. Read More

    Features and outcomes of immunoglobulin therapy in patients with Good syndrome at Thailand's largest tertiary referral hospital.
    Asian Pac J Allergy Immunol 2018 Jun 11. Epub 2018 Jun 11.
    Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Good syndrome (GS) is an adult-onset immunodeficiency characterized by coexisting thymoma and hypogammaglobulinemia. Clinical course after treatment with intravenous immunoglobulin (IVIg) has rarely been reported.

    Objective: To investigate and report the clinical course and outcomes of GS patients after treatment with IVIg at Thailand's largest national tertiary referral hospital METHODS: This retrospective chart review included patients diagnosed with GS and treated with IVIg during the 1 January 2005 to 31 December 2015 study period. Read More

    Resolution of Herpes Simplex in the Nose Wing Region using Photodynamic Therapy and Photobiomodulation.
    Photodiagnosis Photodyn Ther 2018 Jun 7. Epub 2018 Jun 7.
    (b)Postgraduate Program in Dentistry, CEUMA University, Rua Josué Montello, 1, Jardim Renascença II, 65075-120, São Luís, MA, Brazil. Electronic address:

    Acyclovir-induced thrombocytopaenia in a patient with SLE.
    BMJ Case Rep 2018 Jun 8;2018. Epub 2018 Jun 8.
    Rheumatology, Nicosia General Hospital, Nicosia, Cyprus.
    Acyclovir has been used in the treatment of herpes simplex and varicella zoster viral infections for over 30 years. The side effects of oral treatment at standard doses are rare and include headache, diarrhoea, dizziness and malaise. We report a patient with a new diagnosis of systemic lupus erythematosus (SLE) who developed thrombocytopaenia within days on a therapeutic dose with acyclovir. Read More

    The study of leukocyte phagocytic activity in the presence of herpetic infection and stroke.
    Wiad Lek 2018 ;71(1 pt 2):155-159
    Bogomolets National Medical University, Kyiv, Ukraine.
    Objective: Inrtoduction: Post-stroke complications are one of the urgent and insufficiently resolved problems. According to different literature data 23% to 65% of patients suffer from the post-stroke development of an infectious process. Herpes simplex virus type 1 and 2 can also be etiological factors of stroke development, however their reactivation is seldom mentioned in clinical observations. Read More

    Lipschütz ulcer and group A streptococcal tonsillitis.
    BMJ Case Rep 2018 Jun 6;2018. Epub 2018 Jun 6.
    Pediatric Department, Hospital Vila Franca de Xira, Vila Franca de Xira, Portugal.
    Lipschütz ulcers (LU) are non-sexually related genital ulcers, rarely reported. We describe a healthy 11-year-old girl, who presented with fever and a painful vulvar ulcer associated with erythematous tonsillitis. Throat swab test for Group A Streptococcus (GAS) was positive. Read More

    The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins.
    Mol Immunol 2018 Jun 4;101:55-64. Epub 2018 Jun 4.
    Department of Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands. Electronic address:
    Herpesviruses encode numerous immune evasion molecules that interfere with the immune system, particularly with certain stages in the MHC class I antigen presentation pathway. In this pathway, the transporter associated with antigen processing (TAP) is a frequent target of viral immune evasion strategies. This ER-resident transporter is composed of the proteins TAP1 and TAP2, and plays a crucial role in the loading of viral peptides onto MHC class I molecules. Read More

    Peripheral Facial Palsy in Emergency Department.
    Iran J Otorhinolaryngol 2018 May;30(98):145-152
    Department of Otorhinolaryngology, Centro Hospitalar Vila Nova de Gaia, Espinho, Portugal.
    Introduction: Peripheral facial palsy (PFP) is commonly diagnosed in every emergency department. Despite being a benign condition in most cases, PFP causes loss in quality of life mostly due to facial dysmorphia. The etiology of PFP remains unknown in most cases, while medical opinion on epidemiology, risk factors and optimal treatment is not consensual. Read More

    Knock-down of the HSV-1 Latency-Associated Transcript Reduces Reactivation from Latency.
    J Virol 2018 Jun 6. Epub 2018 Jun 6.
    Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA
    During Herpes Simplex Virus (HSV) latency, most viral genes are silenced with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long non-coding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT blocked apoptosis and promoted efficient establishment of latency suggested that its effects on reactivation were secondary to establishment. Read More

    Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates.
    J Clin Microbiol 2018 Jun 6. Epub 2018 Jun 6.
    Children's Hospital Colorado, Department of Pathology and Laboratory Medicine. 13123 E 16 Ave, Aurora, Colorado 80045, USA.
    The American Academy of Pediatrics currently recommends herpes simplex virus (HSV) culture over PCR for testing of swabs of the conjunctivae, mouth, nasopharynx, and rectum (surface swabs) in neonates. To compare the performance and time to results of HSV PCR with HSV culture in surface swabs from neonates. Banked multisource surface samples that had previously been cultured for HSV from infants less than or equal to 30 days old collected from January 2017 to December 2017 were identified and tested retrospectively by HSV PCR. Read More

    Hemidesmus indicus (L.) R. Br. extract inhibits the early step of herpes simplex type 1 and type 2 replication.
    New Microbiol 2018 Jun 6;41(2). Epub 2018 Jun 6.
    Department of Life Quality Sciences, University of Bologna, Corso Augusto 237, 47921 Rimini, Italy.
    Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) cause several clinically relevant syndromes in both adults and neonates. Despite the availability of efficient anti-HSV agents, the search for new therapeutic approaches is highly encouraged due to the increasing drug resistance of virus strains. Medicinal plants represent a source of potential bioactive compounds. Read More

    Vertikale Übertragung des Herpes-simplex-Virus: eine Aktualisierung.
    J Dtsch Dermatol Ges 2018 Jun;16(6):685-693
    Department of Dermatology, Faculty of Medicine University of Debrecen, Ungarn.
    Infektionen mit den Herpes-simplex-Viren (HSV)-1 und -2 haben weltweit eine hohe Prävalenz. Eine HSV-Infektion während der Schwangerschaft kann eine neonatale Herpes-Infektion verursachen, die durch eine lebenslange Infektion mit Latenz- und Reaktivierungsperioden gekennzeichnet ist. Ein Säugling kann sich in utero (5 %), peripartal (85 %) oder postnatal (10 %) mit dem HS-Virus infizieren. Read More

    A Case Report of a Child with Bell's Palsy.
    Cureus 2018 Apr 2;10(4):e2408. Epub 2018 Apr 2.
    Medical Doctor, Bharati Vidyapeeth Deemed University Medical College and Hospital , Sangli, India, Mumbai, IND.
    Bell's palsy is a neuropathy involving the seventh cranial nerve, also known as the facial nerve. It is usually caused by traumatic, infective, inflammatory or compressive conditions on the nerve. Many cases are also with no identifiable etiologies and are classified as idiopathic. Read More

    Stability and anti-tumor effect of oncolytic herpes simplex virus type 2.
    Oncotarget 2018 May 15;9(37):24672-24683. Epub 2018 May 15.
    National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei Provincial Cooperative Innovation Center of Industrial Fermentation, Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430068, Hubei, China.
    Oncolytic virotherapy is a new therapeutic strategy based on the inherent cytotoxicity of viruses and their ability to replicate and spread in tumors in a selective manner. We constructed a new type of oncolytic herpes simplex virus type 2 (oHSV-2, named OH2) to treat human cancers, but a systematic evaluation of the stability and oncolytic ability of this virus is lacking. In this study, we evaluated its physical stability, gene modification stability and biological characteristics stability, including its anti-tumor activity in an animal model. Read More

    RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses.
    Front Immunol 2018 22;9:1083. Epub 2018 May 22.
    State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
    The RING-domain E3 ligases (RING E3s), a group of E3 ligases containing one or two RING finger domains, are involved in various cellular processes such as cell proliferation, immune regulation, apoptosis, among others. In the host, a substantial number of the RING E3s have been implicated to inhibit viral replication through regulating immune responses, including activation and inhibition of retinoic acid-inducible gene I-like receptors, toll-like receptors, and DNA receptor signaling pathways, modulation of cell-surface expression of major histocompatibility complex, and co-stimulatory molecules. During the course of evolution and adaptation, viruses encode RING E3s to antagonize host immune defense, such as the infected cell protein 0 of herpes simplex virus type 1, the non-structural protein 1 of rotavirus, and the K3 and K5 of Kaposi's sarcoma-associated herpesvirus. Read More

    Decompressive craniectomy as salvage treatment in herpes simplex encephalitis: two case reports.
    Int J Infect Dis 2018 Jun 2. Epub 2018 Jun 2.
    University Hospital for Infectious Diseases "Dr Fran Mihaljevic", Department for Intensive Care Medicine and Neuroinfectology, Zagreb, Croatia; School of Medicine University of Zagreb, Zagreb, Croatia.
    Herpes simplex encephalitis is a rare disease with significant morbidity and mortality, although targeted therapy is widely available. We present two cases of herpes simplex encephalitis in previously healthy, young adults treated with acyclovir who developed severe brain edema. Decompressive craniectomy prevented imminent brain herniation and fatal outcome in both our patients. Read More

    Loss of ATP2A2 Allows Herpes Simplex Virus 1 Infection of a Human Epidermis Model by Disrupting Innate Immunity and Barrier Function.
    J Invest Dermatol 2018 Jun 2. Epub 2018 Jun 2.
    Department of Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan; Department of Dermatology, Fukuoka University Hospital, Fukuoka, Japan.
    Destruction of epidermal barrier function associated with atopic dermatitis or Darier's disease often causes severe secondary skin infections. Patients with skin barrier disorders often repeatedly acquire Kaposi varicelliform eruption, which is caused by herpes simplex virus, but the underlying mechanisms and effective preventive methods have yet to be found. Viral infection through an impaired epidermal barrier can be prevented by enhancing innate immunity and/or inhibiting viral entry. Read More

    p53 and the Viral Connection: Back into the Future .
    Cancers (Basel) 2018 Jun 4;10(6). Epub 2018 Jun 4.
    Department of Molecular Cell Biology, Weizmann Institute of Science, 76100 Rehovot, Israel.
    The discovery of the tumor suppressor p53, through its interactions with proteins of tumor-promoting viruses, paved the way to the understanding of p53 roles in tumor virology. Over the years, accumulating data suggest that WTp53 is involved in the viral life cycle of non-tumor-promoting viruses as well. These include the influenza virus, smallpox and vaccinia viruses, the Zika virus, West Nile virus, Japanese encephalitis virus, Human Immunodeficiency Virus Type 1, Human herpes simplex virus-1, and more. Read More

    [Pemphigus and herpes: Multicentre survey and literature review].
    Ann Dermatol Venereol 2018 Jun 1. Epub 2018 Jun 1.
    Service de dermatologie, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris (AP-HP), 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France; Centre de référence des maladies bulleuses auto-immunes MALIBUL, 76000 Rouen France. Electronic address:
    Background: Although herpes superinfection is a well-known complication of pemphigus, it has not been widely investigated.

    Aim: To investigate the frequency and features of herpes infection in patients with ongoing pemphigus.

    Patients And Methods: We carried out a multicenter retrospective study between 2008 and 2016 in patients with newly diagnosed pemphigus presenting active herpes infection. Read More

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