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    1 OF 937

    Transfer of Anti-Rotavirus Antibodies during Pregnancy and in Milk Following Maternal Vaccination with a Herpes Simplex Virus Type-1 Amplicon Vector.
    Int J Mol Sci 2017 Feb 16;18(2). Epub 2017 Feb 16.
    Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
    Rotaviruses (RVs) are important enteric pathogens of newborn humans and animals, causing diarrhea and in rare cases death, especially in very young individuals. Rotavirus vaccines presently used are modified live vaccines that lack complete biological safety. Previous work from our laboratory suggested that vaccines based on in situ produced, non-infectious rotavirus-like particles (RVLPs) are efficient while being entirely safe. Read More

    The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 Feb 16. Epub 2017 Feb 16.
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD).

    Objective: We sought to determine the inpatient burden and comorbidities of PAIBD.

    Methods: We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations. Read More

    False responses of Renilla luciferase reporter control to nuclear receptor TR4.
    Mol Cell Biochem 2017 Feb 16. Epub 2017 Feb 16.
    Departments of Medicine, University of California, Los Angeles, CA, USA.
    Renilla luciferase reporter is a widely used internal control in dual luciferase reporter assay system, where its transcription is driven by a constitutively active promoter. However, the authenticity of the Renilla luciferase response in some experimental settings has recently been questioned. Testicular receptor 4 (TR4, also known as NR2C2) belongs to the subfamily 2 of nuclear receptors. Read More

    Tuberculosis of Glans Penis- A Rare Presentation.
    J Clin Diagn Res 2016 Dec 1;10(12):PD05-PD06. Epub 2016 Dec 1.
    Professor, Department of Surgery, Madurai Medical College , Madurai, Tamil Nadu, India .
    Tuberculosis (TB) of penis is a very rare entity, even in developing countries. It may present as primary or secondary to Pulmonary TB (PTB). Penile TB mimics carcinoma penis, granulomatous penile ulcer, genital herpes simplex, granuloma inguinale and HIV infection. Read More

    Seroprevalence of Common Viral Diseases: A Hospital Based Study from Amritsar, India.
    J Clin Diagn Res 2016 Dec 1;10(12):DC15-DC19. Epub 2016 Dec 1.
    Research Assistant, Department of Viral Research and Diagnostic Laboratory, Government Medical College , Amritsar, Punjab, India .
    Introduction: There is a paucity of published data on epidemiology of the viral infections in Punjab, India. The Viral Research and Diagnostic Laboratory (VRDL) located at Government Medical College (GMC), Amritsar conducts the initial diagnosis of common viruses circulating in the region.

    Aim: To report the seroprevalence of various viral diseases in Amritsar and neighboring districts of Punjab along with the demographic and geographical data of the patients. Read More

    In vitro anti-herpes simplex virus-2 activity of Salvia desoleana Atzei & V. Picci essential oil.
    PLoS One 2017 16;12(2):e0172322. Epub 2017 Feb 16.
    Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Torino, Italy.
    Salvia desoleana Atzei & V. Picci is an indigenous species in Sardinia island used in folk medicine to treat menstrual, digestive and central nervous system diseases. Nowadays, it is widely cultivated for the pleasant smell of its essential oil (EO), whose antimicrobial and antifungal activities have already been screened. Read More

    IL-4 mediated by HSV vector suppresses morphine withdrawal response through decreasing TNFα, NR2B and pC/EBPβ in the periaqueductal gray in rats.
    Gene Ther 2017 Feb 16. Epub 2017 Feb 16.
    Department of Anesthesiology, University of Miami Miller School of Medicine, Miami, FL, USA.
    Chronic opiates induce the development of physical dependence. Opioid physical dependence characterized by withdrawal symptoms, may have very long-lasting effects on the motivation for reward, including the incubation of cue-induced drug-seeking behavior. Elucidation of the mechanisms involved in physical dependence is crucial to developing more effective treatment strategies for opioid dependence. Read More

    The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation.
    Neuropsychopharmacology 2017 Feb 16. Epub 2017 Feb 16.
    The Hospital for Sick Children, Department of Neuroscience and Mental Health, Toronto, ON, Canada.
    The formation of long-lasting memories requires coordinated changes in gene expression and protein synthesis (Davis and Squire, 1984; Duvarci et al, 2008; Hernandez and Abel, 2008). Although many studies implicate DNA modifications (DNA methylation, histone modifications) in memory formation, the contributions of RNA modifications remain largely unexplored. Here, we investigated the role of mRNA methylation in hippocampal-dependent memory formation in mice. Read More

    HIV and STI s among men who have sex with men in Dodoma municipality, Tanzania: a cross-sectional study.
    Sex Transm Infect 2017 Feb 15. Epub 2017 Feb 15.
    Department of Behavioural Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
    Objectives: To determine the seroprevalence of HIV, STI and related risks among men who have sex with men (MSM) in Dodoma municipality, Tanzania.

    Methods: A cross-sectional study using respondent-driven sampling was employed to recruit study participants aged 18 years and above. Data on sociodemographics, HIV/STI knowledge and sexual practices were collected. Read More

    Investigations in GABAA receptor antibody-associated encephalitis.
    Neurology 2017 Feb 15. Epub 2017 Feb 15.
    From the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (M.S., M.P.-P., T.A., M.R.R., F.G., J.D.), University of Barcelona, Spain; University of Lausanne (UNIL) (M.S.), Switzerland; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (M.P.-P., T.A., M.R.R., J.D., F.G.), Madrid, Spain; Neurology Service (T.A., J.D.), Hospital Sant Joan de Déu, Barcelona, Spain; Neurology Division, Hospital das Clínicas (M.M.S.), São Paulo University, Brazil; Hospital de Base (F.J.C.), Brasília, Brazil; Service of Neurology (M.I.B.A.) and Service of Immunology (M.R.J.B.), University Hospital of Son Espases, Mallorca, Spain; Department of Neurology (L.B., M.G.), Children's Hospital, Boston, MA; Pediatric Neurology Section (A.F.), Vall d'Hebron University Hospital, Barcelona, Spain; Hospital Nacional Edgardo Rebagliati Martins (R.L.C.O.), Lima, Peru; Department of Neurology (M.R.R., J.D.), University of Pennsylvania, Philadelphia; Service of Neurology (F.G., J.D.), Hospital Clínic; and Catalan Institution for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
    Objective: To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA receptor (GABAAR) encephalitis.

    Methods: Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABAAR were determined using reported techniques. Read More

    Acute HIV-1 infection presenting with fulminant encephalopathy.
    Int J STD AIDS 2017 Jan 1:956462417693734. Epub 2017 Jan 1.
    1 Department of Internal Medicine, Soonchunhyang University Hospital, Seoul, Korea.
    Human immunodeficiency virus (HIV)-1 directly affects the nervous system, causes distinct neurological symptoms, and indirectly results in opportunistic infections, which include herpes virus simplex (HSV)-1, HSV-2, varicella zoster virus, and cytomegalovirus encephalitis caused by immunodeficiency. Early HIV-1 invasion of the central nervous system is also possible, and acute encephalopathy is a potentially lethal complication. We encountered a case of fulminant encephalopathy as a primary presentation of acute HIV-1 infection, in which highly active antiretroviral treatment resulted in a full clinical recovery. Read More

    Distinct effects of the cervico-vaginal microbiota and herpes simplex type 2 infection on female genital tract immunology.
    J Infect Dis 2017 Feb 13. Epub 2017 Feb 13.
    Departments of Medicine (BS, TJY, SH, KS, RK) and Immunology (BS, TJY, RK), University of Toronto, Toronto, Ontario, Canada.

    Cultured corneas show dendritic spread and restrict herpes simplex virus infection that is not observed with cultured corneal cells.
    Sci Rep 2017 Feb 15;7:42559. Epub 2017 Feb 15.
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, IL 60612, USA.
    Herpes simplex virus-1 (HSV-1) causes life-long morbidities in humans. While fever blisters are more common, occasionally the cornea is infected resulting in vision loss. A very intriguing aspect of HSV-1 corneal infection is that the virus spread is normally restricted to only a small fraction of cells on the corneal surface that connect with each other in a dendritic fashion. Read More

    [The alpha-herpesviridae in dermatology : Herpes simplex virus types I and II. German version].
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgien.
    This review on herpes simplex virus type I and type II (HSV-I, HSV-II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV-I infection; HSV-related folliculitis; verrucous HSV-I and HSV-II lesions; the role of recurrent HSV-I infection in burning mouth syndrome; HSV-I and HSV-II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV-I or HSV-II are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. Read More

    The alpha-herpesviridae in dermatology : Herpes simplex virus types I and II.
    Hautarzt 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, CHU of Sart Tilman, University of Liège, 4000, Liège, Belgium.
    This review on herpes simplex virus type I and type II (HSV‑I, HSV‑II) summarizes recent developments in clinical manifestations and treatment interventions for primary and recurrent orolabial and genital herpes, as well as those regarding vaccination issues. Among the clinical presentations, the relationship between pyogenic granuloma and chronic HSV‑I infection; HSV-related folliculitis; verrucous HSV‑I and HSV‑II lesions; the role of recurrent HSV‑I infection in burning mouth syndrome; HSV‑I and HSV‑II infection of the periareolar area; zosteriform HSV; the "knife-cut sign"; and the preferential colonization and infection of preexisting dermatoses by HSV‑I or HSV‑II are discussed. The usual antiviral treatment regimens for primary and recurrent orolabial and genital herpes are compared to short-term and one-day treatment options. Read More

    Anti-HSV-2 activity of Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids.
    BMC Complement Altern Med 2017 Feb 14;17(1):110. Epub 2017 Feb 14.
    Reproductive Cell Biology Laboratory, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, 110 067, India.
    Background: Development of new and effective therapeutics for sexually transmitted herpes simplex virus-2 (HSV-2) infection is important from public health perspective. With an aim to identify natural products from medicinal plants, in the present study, the potential of Terminalia chebula Retz was investigated for its activity against HSV-2.

    Methods: Fruits of Terminalia chebula Retz were used to prepare 50% ethanolic extract. Read More

    Common Skin Conditions in Children: Skin Infections.
    FP Essent 2017 Feb;453:26-32
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin infections account for a significant subset of dermatologic conditions of childhood. Common cutaneous viral infections in children include warts, molluscum contagiosum, hand-foot-and-mouth disease, and herpes simplex. Although viral infections are self-limited and often only mildly symptomatic, they can cause anxiety, embarrassment, and health care use. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Infectivity inhibition by overlapping synthetic peptides derived from the gH/gL heterodimer of herpes simplex virus type 1.
    J Pept Sci 2017 Feb 14. Epub 2017 Feb 14.
    Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138, Naples, Italy.
    Herpes simplex virus (HSV) is a human pathogen that infects epithelial cells. The cutaneous lesions, caused by the virus, spread to the nervous system creating several complications. Fusion of host membranes with the viral envelope is mandatory and mediated by a group of glycoproteins conserved in all Herpesviridae subfamilies, such as the glycoproteins B (gB), H (gH), L (gL) and D (gD). Read More

    Herpes Simplex Virus in the Neonate.
    Pediatr Ann 2017 Feb;46(2):e42-e46
    Neonatal herpes simplex virus (HSV) disease is a serious, life-threatening condition that should be considered in neonates with fever, vesicular rash, culture negative sepsis, and/or seizure activity. Because signs and symptoms of neonatal HSV may closely resemble those of bacterial sepsis, a thorough history and appropriate testing are imperative to accurately confirm the diagnosis. Failure to treat vesicular lesions from HSV in the neonate leads to an approximate 75% chance of progression to disseminated disease and/or meningoencephalitis. Read More

    Spectrum of Magnetic Resonance Imaging Features in Unilateral Optic Tract Dysfunction.
    J Neuroophthalmol 2017 Mar;37(1):17-23
    Departments of Ophthalmology and Visual Sciences (KMK, JDT), Radiology (Neuroradiology) (FFRR, AS) and Neurology (JDT), Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.
    Background: Optic tract dysfunction may be the predominant or only clinical manifestation of an intracranial disorder including mass legion, ischemic infarct, inflammatory disease, and trauma. Documentation of the neuroimaging features of these lesions is limited to reports mostly published before the availability of MRI. This study was undertaken to document the spectrum of MRI features in patients presenting with optic tract dysfunction. Read More

    Delayed Temporal Lobe Hemorrhage After Initiation of Acyclovir in an Immunocompetent Patient with Herpes Simplex Virus-2 Encephalitis: A Case Report.
    Cureus 2017 Jan 15;9(1):e980. Epub 2017 Jan 15.
    Neurosurgery, Medstar Georgetown University Hospital.
    Herpes simplex virus (HSV) is the most common cause of non-epidemic, sporadic, acute focal encephalitis in the United States. Inflammation of the vasculature makes them friable and susceptible to hemorrhage. Massive hemorrhage, though rare, can present in a delayed fashion after initiation of acyclovir and often requires surgical intervention. Read More

    Diagnosis and management of acute encephalitis.
    Handb Clin Neurol 2017 ;140:337-347
    Overlook Medical Center, Summit, NJ; Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:
    Encephalitis is typically viral (approximately half of diagnosed cases) or autoimmune (about a quarter) with the remainder remaining undiagnosable at this time. All require general supportive care but only a minority requires intensive care admission - in these intubation, to protect the airway or to treat status epilepticus with anesthetic drugs, may be needed. In some dysautonomia with wide blood pressure fluctuations is the principal concern. Read More

    Prevalence of Concomitant Acute Bacterial Meningitis in Neonates with Febrile Urinary Tract Infection: A Retrospective Cross-Sectional Study.
    J Pediatr 2017 Feb 6. Epub 2017 Feb 6.
    Section of Pediatric Emergency Medicine, Section of Pediatric Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, TX.
    Objective: To describe the frequency of concomitant acute bacterial meningitis (ABM) in neonates with febrile urinary tract infection (UTI).

    Study Design: This was a retrospective cross-sectional study from 2005 to 2013 of infants ≤30 days old evaluated in the emergency department of a quaternary care children's hospital with fever and laboratory-confirmed UTI. Definite ABM was defined as cerebrospinal fluid (CSF) culture with growth of pathogenic bacteria and probable ABM if pleocytosis with ≥ 20 white blood cell was present in an antibiotic-pretreated patient. Read More

    Recurrent herpes labialis and HSV-1 herpes genitalis: which is the link?
    G Ital Dermatol Venereol 2017 Feb 8. Epub 2017 Feb 8.
    DISSAL, Department of Dermatology, IRCSS AOU "San Martino-IST", University of Genoa, Genoa, Italy.
    Background: Recently, Herpes simplex virus (HSV)-1 seroprevalence declined among adolescents, rendering young people lacking HSV-1 antibodies more susceptible to genital HSV-1 acquisition, if sexually exposed. The aim of the present study was to identify the possible risk factors for the development of HSV-1 related herpes genitalis (HG).

    Methods: From January 2012 to December 2015, patients with HG attending three Sexually Transmitted Infections Units in Northern Italy were recruited. Read More

    Seroprevalence and Co-Infection of Human Immunodeficiency Virus (HIV) and Herpes Simplex Virus (HSV) Among Pregnant Women in Lokoja, North-Central Nigeria.
    Iran Red Crescent Med J 2016 Oct 10;18(10):e25284. Epub 2016 Aug 10.
    Infectious Diseases and Environmental Health Research Group, Faculty of Life Sciences, Department of Microbiology, University of Ilorin, Ilorin, Nigeria.
    Background: Herpes simplex virus 1 (HSV-1) is normally associated with orofacial (orolabial) infections and encephalitis, whereas HSV-2 usually causes genital infections and can be transmitted from infected mothers to neonates. The evidence suggesting that HSV is facilitating the spread of the global human immunodeficiency virus (HIV) epidemic and the risk posed by these synergies to neonates in developing countries informed this study.

    Objectives: To determine the seroprevalence and co-infection of HIV and HSV, as well as their associated risk factors, in Lokoja, Nigeria. Read More

    Impaired STING pathway in the human osteosarcoma U2OS cells contributes to the growth of ICP0-null mutant herpes simplex virus.
    J Virol 2017 Feb 8. Epub 2017 Feb 8.
    University of Kansas Medical Center, Department of Microbiology, Molecular Genetics, Immunology, 3901 Rainbow Blvd, Building Hixon, room 3009, Kansas City, KS, 66160
    Human herpes simplex virus-1 (HSV-1) is a wide spread pathogen with 80% of the population being latently infected. To successfully evade the host the virus has evolved strategies to counteract antiviral responses, including the gene silencing and innate immunity machineries. The immediately early protein of the virus, Infected Cell Protein 0 (ICP0) plays central role in these processes. Read More

    Time-resolved global and chromatin proteomics during herpes simplex virus (HSV-1) infection.
    Mol Cell Proteomics 2017 Feb 8. Epub 2017 Feb 8.
    Children's Hospital of Philadelphia, United States;
    Herpes simplex virus (HSV-1) lytic infection results in global changes to the host cell proteome and the proteins associated with host chromatin. We present a system level characterization of proteome dynamics during infection by performing a multi-dimensional analysis during HSV-1 lytic infection of human foreskin fibroblast (HFF) cells. Our study includes identification and quantification of the host and viral proteomes, phosphoproteomes, chromatin bound proteomes and post-translational modifications (PTMs) on cellular histones during infection. Read More

    Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons.
    Pathogens 2017 Feb 7;6(1). Epub 2017 Feb 7.
    Department of Population Health Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA.
    Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathetic and sensory neurons. However, adult sensory neurons are no longer dependent on NGF for survival, some populations cease expression of NGF receptors postnatally, and the viruses preferentially establish latency in different populations of sensory neurons responsive to other neurotrophic factors (NTFs). Read More

    Graphene-Based "Hot Plate" for the Capture and Destruction of the Herpes Simplex Virus Type 1.
    Bioconjug Chem 2017 Feb 16. Epub 2017 Feb 16.
    The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University , Ramat Gan 5290002, Israel.
    The study of graphene-based antivirals is still at a nascent stage and the photothermal antiviral properties of graphene have yet to be studied. Here, we design and synthesize sulfonated magnetic nanoparticles functionalized with reduced graphene oxide (SMRGO) to capture and photothermally destroy herpes simplex virus type 1 (HSV-1). Graphene sheets were uniformly anchored with spherical magnetic nanoparticles (MNPs) of varying size between ∼5 and 25 nm. Read More

    Manufacturing of recombinant adeno-associated viruses using mammalian expression platforms.
    Biotechnol J 2017 Feb 8. Epub 2017 Feb 8.
    Département de génie chimique, Université Laval, Québec, QC, Canada.
    Manufacturing practices for recombinant adeno-associated viruses (AAV) have improved in the last decade through the development of new platforms in conjunction with better production and purification methods. In this review, we discuss the advantages and limitations of the most popular systems and methods employed with mammalian cell platforms. Methods and systems such as transient transfection, packaging and producer cells and adenovirus and herpes simplex virus are described. Read More

    Herpes simplex keratitis: challenges in diagnosis and clinical management.
    Clin Ophthalmol 2017 19;11:185-191. Epub 2017 Jan 19.
    Department of Ophthalmology, Saint Louis University.
    Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea, where it restimulates an inflammatory response. Read More

    Oncolytic Herpes Simplex Virus Vectors Fully Retargeted to Tumor-Associated Antigens.
    Curr Cancer Drug Targets 2017 Feb 5. Epub 2017 Feb 5.
    Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo,. Japan.
    Oncolytic virotherapy is a novel therapeutic modality for malignant diseases that exploits selective viral replication in cancer cells. Herpes simplex virus (HSV) is a promising agent for oncolytic virotherapy due to its broad cell tropism and the identification of mutations that favor its replication in tumor over normal cells. However, these attenuating mutations also tend to limit the potency of current oncolytic HSV vectors that have entered clinical studies. Read More

    A particular case of cytomegalovirus infection in infancy.
    Rom J Morphol Embryol 2016 ;57(4):1371-1374
    Department of Pediatrics, "Louis Turcanu" Emergency Hospital for Children, Timisoara, Romania;
    The clinical spectrum of perinatal infection varies from asymptomatic infection or mild disease to severe systemic involvement. The aim of this paper is to present a severe intrauterine infection, which led to difficulties in diagnosis and unfavorable evolution.

    Case Presentation: M. Read More

    Participation of 3-O-sulfated heparan sulfates in the protection of macrophages by herpes simplex virus-1 glycoprotein D and cyclophilin B against apoptosis.
    FEBS Open Bio 2017 Feb 24;7(2):133-148. Epub 2016 Dec 24.
    Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) UMR 8576 CNRS University of Lille France.
    Heparan sulfates (HS) are involved in numerous biological processes, which rely on their ability to interact with a large panel of proteins. Although the reaction of 3-O-sulfation can be catalysed by the largest family of HS sulfotransferases, very few mechanisms have been associated with this modification and to date, only glycoprotein D (gD) of herpes simplex virus-1 (HSV-1 gD) and cyclophilin B (CyPB) have been well-described as ligands for 3-O-sulfated HS. Here, we hypothesized that both ligands could induce the same responses via a mechanism dependent on 3-O-sulfated HS. Read More

    Positive correlation of anti-herpes simplex type I virus antibody levels with pemphigus vulgaris disease status and activity in a large patient cohort.
    Eur J Dermatol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Dermatology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Clinical and Translational Research Center, Rm. 6078, 875 Ellicott Street, Buffalo, NY 14203, USA.
    It is well accepted that pemphigus vulgaris (PV) is genetically linked to specific HLA class II subtypes. Environmental factors, including the role of herpes simplex virus (HSV1) in disease manifestation, have also been implicated, but in a limited number of patients and with inconsistent results. To clarify an association between HSV1 and PV in a large data set, including a stratification by dynamic and static clinical parameters, including disease activity, therapy status, HLA association, and gender. Read More

    Alliacane sesquiterpenoids from submerged cultures of the basidiomycete Inonotus sp. BCC 22670.
    Phytochemistry 2017 Feb 4. Epub 2017 Feb 4.
    National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
    Nine alliacane sesquiterpenoids, inonoalliacanes A-I, were isolated from culture broth of the basidiomycete Inonotus sp. BCC 22670. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Read More

    DNA Vaccine Encoding HPV16 Oncogenes E6 and E7 Induces Potent Cell-mediated and Humoral Immunity Which Protects in Tumor Challenge and Drives E7-expressing Skin Graft Rejection.
    J Immunother 2017 Feb/Mar;40(2):62-70
    *Admedus Vaccines Pty Ltd †Diamantina Institute, University of Queensland, Brisbane, Qld, Australia.
    We have previously shown that a novel DNA vaccine technology of codon optimization and the addition of ubiquitin sequences enhanced immunogenicity of a herpes simplex virus 2 polynucleotide vaccine in mice, and induced cell-mediated immunity when administered in humans at relatively low doses of naked DNA. We here show that a new polynucleotide vaccine using the same technology and encoding a fusion protein of the E6 and E7 oncogenes of high-risk human papillomavirus type 16 (HPV16) is immunogenic in mice. This vaccine induces long-lasting humoral and cell-mediated immunity and protects mice from establishment of HPV16-E7-expressing tumors. Read More

    Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma.
    Drug Deliv 2017 Nov;24(1):289-299
    a Gallipoli Medical Research Institute, Greenslopes Private Hospital , Brisbane , QLD , Australia.
    Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available for advanced HCC press for novel and effective treatment modalities. Gene therapy represents one of the most promising therapeutic options. Read More

    Multiplex PCR for the Detection of 10 Viruses Causing Encephalitis/Encephalopathy and its Application to Clinical Samples Collected from Japanese Children with Suspected Viral.
    Clin Lab 2017 Jan;63(1):91-100
    Background: Acute encephalitis is a serious neurological condition having a high mortality rate and affecting both children and adults. This study aimed to develop a multiplex PCR method for the simultaneous screening of clinical samples for the presence of the 10 viruses presently considered as the major viral causes of acute encephalitis/ encephalopathy in Asia.

    Methods: Using previously published primers that have been widely used to screen for herpes virus-6, influenza A virus, human parechovirus, herpes simplex viruses 1 and 2, Japanese encephalitis virus, group A rotavirus, enterovirus, adenovirus, and dengue virus in clinical samples, a single-tube multiplex PCR assay was developed and was tested for its sensitivity and specificity. Read More

    A systematic review of the relationship between dystemprament (sue Mizaj) and treatments and management of diseases (Ilaj and Eslah-e-Mizaj).
    Electron Physician 2016 Dec 25;8(12):3378-3384. Epub 2016 Dec 25.
    Research Assistant, Molecular and Cellular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
    Background: Temperament refers to four different humors differentiating in individuals and, as a result, proposes specific therapy for diseases as well as special types of management (avoidance).

    Objective: The aim of this study was to overview the relationship between dystemprament and treatment and management of diseases.

    Methods: A computerized search of published articles was performed using PubMed, Scopus, Web of Science, and Medline databases as well as local sources from 1965 to 2016. Read More

    Antiviral Treatments.
    Clin Chest Med 2017 Mar 13;38(1):139-153. Epub 2016 Dec 13.
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue Suite 900, Chicago, IL 60611, USA. Electronic address:
    Most viral respiratory tract infections are caused by classic respiratory viruses, including influenza, respiratory syncytial virus, human metapneumovirus, parainfluenza, rhinovirus, and adenovirus, whereas other viruses, such as herpes simplex, cytomegalovirus, and measles virus, can opportunistically affect the respiratory tract. The M2 inhibitors, amantadine and rimantadine, were historically effective for the prevention and treatment of influenza A but all circulating strains are currently resistant to these drugs. Neuraminidase inhibitors are the sole approved class of antivirals to treat influenza. Read More

    Corticosteroid-responsive focal granulomatous herpes simplex type-1 encephalitis in adults.
    Pract Neurol 2017 Feb 2. Epub 2017 Feb 2.
    Wessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
    We describe corticosteroid-responsive focal granulomatous encephalitis as a manifestation of herpes simplex virus (HSV) type 1 disease in the brain: something easily missed and easily treated. Two adult cases presented with cognitive symptoms progressing over weeks, despite aciclovir treatment. Brain imaging showed temporal lobe abnormalities, with gadolinium enhancement but no abnormal diffusion restriction. Read More

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