49,023 results match your criteria Herpes Simplex


The Herpes simplex's reactivation after surgical treatment of Trigeminal Neuralgia. A retrospective cohort study.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Human Neurosciences Department, Neurosurgery Division "Sapienza" University, AOU Policlinico Umberto I, Rome, Italy.

Background: The Herpes Simplex Virus (HSV) reactivation after surgical procedure for trigeminal neuralgia (TN) has been known and recognized since a long time. To date, only few studies, focused on this complication and at present its real incidence remains unknown. The aim of the present paper is to investigate the real incidence of postoperative Herpes Labialis in a cohort of patients treated alternatively with PBC or MVD to outline potentially significant differences among different treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2019.01.226DOI Listing
February 2019

Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Department of Respiratory Medicine, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital of Shenzhen University, Guangdong, Shenzhen, China.

Pulmonary fibrosis is a lethal inflammatory disease. In this study, we aimed to explore the potential-related circular RNAs (circRNAs) and genes that are associated with pulmonary fibrosis. Pulmonary fibrosis rat models were constructed and the fibrosis deposition was detected using hematoxylin and eosin and Masson staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28380DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019

Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen.

Nat Commun 2019 Feb 14;10(1):754. Epub 2019 Feb 14.

Department of Microbiology, New York University School of Medicine, New York, NY, 10016, USA.

Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are sequenced directly, without the recoding and amplification biases inherent to other sequencing methodologies. Here we use direct RNA-seq to profile the herpes simplex virus type 1 (HSV-1) transcriptome during productive infection of primary cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-08734-9DOI Listing
February 2019

The psychopathology of NMDAR-antibody encephalitis in adults: a systematic review and phenotypic analysis of individual patient data.

Lancet Psychiatry 2019 Feb 11. Epub 2019 Feb 11.

Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom; Department of Neurology, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address:

Background: Early immunotherapy administration improves outcomes in patients with N-methyl-D-aspartate receptor (NMDAR)-antibody encephalitis. As most patients with NMDAR-antibody encephalitis present to psychiatrists, the psychopathology of NMDAR-antibody encephalitis needs to be clearly defined to encourage accurate clinical identification and prompt treatment.

Methods: For this systematic review, we searched PubMed for all studies published in English between Jan 1, 2005, and Oct 7, 2017, to identify individually reported adult patients (≥18 years) who satisfied consensus criteria for definite NMDAR-antibody encephalitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2215-0366(19)30001-XDOI Listing
February 2019

Urea dilution of serum for reproducible anti-HSV1 IgG avidity index.

BMC Infect Dis 2019 Feb 14;19(1):164. Epub 2019 Feb 14.

Department of Clinical Microbiology, Virology, Umeå University, SE-901 85, Umeå, Sweden.

Background: Herpes simplex virus type 1 (HSV1), establishes life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe a protocol to generate a reliable and discriminative avidity index (AI) for anti-HSV1 IgG content in human sera.

Methods: Human serum from two distinct cohorts; one a biobank collection (Betula) (n = 28), and one from a clinical diagnostics laboratory at Northern Sweden University Hospital (NUS) (n = 18), were assessed for presence of IgG antibodies against HSV1 by a commercially available ELISA-kit. Read More

View Article

Download full-text PDF

Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3769-xDOI Listing
February 2019
2 Reads

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

Macrodendrite in a Patient With Herpes Simplex Virus Keratitis.

JAMA Ophthalmol 2019 Feb 14;137(2):e183979. Epub 2019 Feb 14.

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2018.3979DOI Listing
February 2019

Acute Hand Infections.

Am Fam Physician 2019 Feb;99(4):228-236

U.S. Marine Corps School of Infantry-East, Camp Geiger, NC, USA.

Acute hand infections are often caused by puncture wounds and are generally classified into superficial or deep infections. Superficial infections occur in the skin and subcutaneous tissues, whereas deep infections can involve the tendon sheaths, adjacent anatomic compartments, deep fascial planes, bursae, joint spaces, and bones. Superficial hand infections are more common than deep infections and are typically managed with elevation, warm soaks, splinting in the position of function, analgesics, and empiric antibiotics when indicated. Read More

View Article

Download full-text PDF

Source
February 2019

The US11 gene of Herpes Simplex Virus 1 promotes neuroinvasion and periocular replication following corneal infection.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Microbiology and Immunology, The Geisel School of Medicine at Dartmouth, Lebanon, NH.

Herpes simplex virus type 1 (HSV-1) cycles between phases of latency in sensory neurons and replication in mucosal sites. HSV-1 encodes two key proteins that antagonize the shutdown of host translation; US11 through preventing PKR activation, and ICP34.5 through mediating eIF2α dephosphorylation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02246-18DOI Listing
February 2019

Comparison of HSV-1 strains circulating in Finland demonstrates the uncoupling of whole-genome relatedness and phenotypic outcomes of viral infection.

J Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biochemistry and Molecular Biology, Center for Infectious Disease Dynamics, and the Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA

A majority of adults in Finland are seropositive carriers of herpes simplex viruses (HSV). Infection occurs at epithelial or mucosal surfaces, after which virions enter innervating nerve endings, eventually establishing lifelong infection in neurons of the sensory or autonomic nervous system. Recent data have highlighted the genetic diversity of HSV-1 strains, and demonstrated apparent geographic patterns in strain similarity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01824-18DOI Listing
February 2019

Infectious complications and NK cell depletion following daratumumab treatment of Multiple Myeloma.

PLoS One 2019 13;14(2):e0211927. Epub 2019 Feb 13.

Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Treatment with Daratumumab (Dara), a monoclonal anti-CD38 antibody of IgG1 subtype, is effective in patients with multiple myeloma (MM). However, Dara also impairs the cellular immunity, which in turn may lead to higher susceptibility to infections. The exact link between immune impairment and infectious complications is unclear. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211927PLOS
February 2019

Interaction between nectin-1 and the human natural killer cell receptor CD96.

PLoS One 2019 13;14(2):e0212443. Epub 2019 Feb 13.

Department of Biological Sciences, Rowan University, Glassboro, New Jersey, United States of America.

Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating and inhibitory signals acquired at the immunological synapse with potential target cells. NK cells express paired receptors from the immunoglobulin family which share common ligands from the nectin family of adhesion molecules. The activating receptor CD226 (DNAM-1) binds to nectin-2 and CD155, which are also recognized by the inhibitory receptor TIGIT. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212443PLOS
February 2019

The recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis.

J Neurovirol 2019 Feb 13. Epub 2019 Feb 13.

Research Center in Infectious Diseases, CHU of Quebec and Laval University, 2705 Boul. Laurier, Quebec City, QC, G1V 4G2, Canada.

The cerebral immune response induced by herpes simplex virus (HSV) encephalitis (HSE) was evaluated in susceptible BALB/c and resistant C57BL/6 mice. BALB/c and C57BL/6 (named C57BL/6-high) mice were respectively infected intranasally with 1 × 10 and 5 × 10 plaque-forming units (PFUs) of HSV-1. C57BL/6 mice (named C57BL/6-low) infected with a low inoculum (1 × 10 PFUs) of HSV-1 were tested in parallel. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13365-019-00730-5DOI Listing
February 2019

Immune characteristics correlating with HSV-1 immune control and effect of squaric acid dibutyl ester on immune characteristics of subjects with frequent herpes labialis episodes.

Immun Inflamm Dis 2019 Feb 12. Epub 2019 Feb 12.

Minneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota.

Introduction: Differences in immune characteristics, including immune gene expression by peripheral blood mononuclear cells (PBMCs), correlating with herpes labialis and good or poor immune control of herpes simplex virus type 1 (HSV-1), and how these characteristics change after dosing with squaric acid dibutyl ester (SADBE), were investigated.

Methods: PBMCs were collected from persons positive for IgG against HSV-1 and having frequent, infrequent, or no herpes labialis outbreaks. The PBMCs were tested for proliferation against HSV-1 and a fungal antigen (Candida) and immune gene expression in the presence of HSV-1 and Candida. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/iid3.241DOI Listing
February 2019

HSV Hepatitis in Pregnancy: A Review of the Literature.

Obstet Gynecol Surv 2019 Feb;74(2):93-98

Staff Physician, University of Arkansas for Medical Sciences, Little Rock, AR.

Importance: Herpes simplex virus (HSV) hepatitis is a rare condition with a high mortality rate. Immunocompromised individuals, including pregnant women, are the most susceptible. When primary infection occurs during pregnancy, risk for disseminated HSV is greatly increased. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/OGX.0000000000000642DOI Listing
February 2019

Fatal Septic Shock Associated with Herpes Simplex Virus Hepatitis: A Case Report.

Eur J Case Rep Intern Med 2018 27;5(12):000982. Epub 2018 Dec 27.

Intensive Care Unit, Iris South Hospitals, Brussels, Belgium.

Herpes simplex viruses are endemic worldwide, with an estimated seroprevalence of approximately 70% in developed countries. However, it is less well known that they are one of the viral causes of fulminant hepatitis (<2%) and constitute <1% of all causes of acute liver failure. We describe the case of an 89-year-old man who developed sepsis caused by a urinary tract infection due to drug-sensitive . Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12890/2018_000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346974PMC
December 2018

Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model.

Oncogene 2019 Feb 12. Epub 2019 Feb 12.

Department of Experimental Medicine, University of Genoa, Genoa, Italy.

Oncolytic herpes simplex viruses are proving to be effective in clinical trials against a number of cancers. Here, R-115, an oncolytic herpes simplex virus retargeted to human erbB-2, fully virulent in its target cells, and armed with murine interleukin-12 was evaluated in a murine model of glioblastoma. We show that a single R-115 injection in established tumors resulted, in about 30% of animals, in the complete eradication of the tumor, otherwise invariably lethal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-019-0737-2DOI Listing
February 2019

Pre-surgical neoadjuvant oncolytic virotherapy confers protection against rechallenge in a murine model of breast cancer.

Sci Rep 2019 Feb 12;9(1):1865. Epub 2019 Feb 12.

CRCHUM - "Centre de recherche du Centre Hospitalier de l'Université de Montréal" and "Institut du cancer de Montréal", Montreal, H2X 0A9, Canada.

The use of oncolytic viruses (OVs) for cancer treatment is emerging as a successful strategy that combines the direct, targeted killing of the cancer with the induction of a long-lasting anti-tumor immune response. Using multiple aggressive murine models of triple-negative breast cancer, we have recently demonstrated that the early administration of oncolytic Maraba virus (MRB) prior to surgical resection of the primary tumor is sufficient to minimize the metastatic burden, protect against tumor rechallenge, cure a fraction of the mice and sensitize refractory tumors to immune checkpoint blockade without the need for further treatment. Here, we apply our surgical model to other OVs: Vesicular stomatitis virus (VSV), Adenovirus (Ad), Reovirus (Reo) and Herpes simplex virus (HSV) and show that all of the tested OVs could positively change the outcome of the treated animals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-38385-7DOI Listing
February 2019

Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.

MBio 2019 Feb 12;10(1). Epub 2019 Feb 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

Herpes simplex virus 1 (HSV-1) switches between two infection programs, productive ("lytic") and latent infection. Some HSV-1 microRNAs (miRNAs) have been hypothesized to help control this switch, and yet little is known about regulation of their expression. Using Northern blot analyses, we found that, despite inherent differences in biogenesis efficiency among six HSV-1 miRNAs, all six exhibited high pre-miRNA/miRNA ratios during lytic infection of different cell lines and, when detectable, in acutely infected mouse trigeminal ganglia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.02856-18DOI Listing
February 2019

Tenofovir gel for prevention of herpes simplex virus type-2 acquisition: findings from the VOICE Trial.

J Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

Magee-Womens Research Institute, Pittsburgh, PA.

Background: Genital infection with herpes simplex virus type-2 (HSV-2) is common, and increases risk of HIV transmission and acquisition. Pericoital use of tenofovir (TFV) gel provided protection from HSV-2 acquisition in the CAPRISA 004 Study.

Methods: We measured estimate of effect of vaginal TFV 1% gel in preventing HSV-2 acquisition among women in VOICE, randomized, double-blind, placebo-controlled trial assessing daily use of oral and vaginal TFV for HIV-1 pre-exposure prophylaxis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiz045DOI Listing
February 2019
1 Read

Coroner's report on the death of a baby from complications of herpes simplex virus type 1 infection.

J Paediatr Child Health 2019 Feb;55(2):239

Department of General Medicine, Women's and Children's Hospital, Adelaide, South Australia, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jpc.14350DOI Listing
February 2019

The Decline of PUVA Therapy in Vietnam: Effective Treatment of Narrow Band UVB in Vietnamese Vitiligo Patients.

Open Access Maced J Med Sci 2019 Jan 28;7(2):256-258. Epub 2019 Jan 28.

University of Rome G. Marconi, Rome, Italy.

Aim: To examine the efficacy and safety of Narrowband ultraviolet B (NB-UVB) in Vietnamese vitiligo patients.

Methods: We recruited thirty-one patients (14 males, 17 females), aged from 7 to 67 years, with both segmental vitiligo (SV) and non-segmental vitiligo (NSV), treated three times weekly with NB-UVB. The starting dose for adults from 15 years old and children less than 15 years old was 200 mJ/cm and 150 mJ/cm, respectively, with 50 mJ/cm and 20 mJ/cm dose increments at each subsequent visit, respectively, until mild erythema lasting less than 24 hrs reported by patient, given for a period of 6 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3889/oamjms.2019.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364711PMC
January 2019

Synthetic lethality of cytolytic HSV-1 in cancer cells with ATRX and PML deficiency.

J Cell Sci 2019 Feb 11. Epub 2019 Feb 11.

Cancer Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW 2145 Australia

Cancers that utilize the Alternative Lengthening of Telomeres (ALT) mechanism for telomere maintenance are often difficult to treat and have a poor prognosis. They are also commonly deficient for expression of ATRX protein, a repressor of ALT activity, and a component of PML nuclear bodies (PML NBs) which are required for intrinsic immunity to various viruses. Here we asked whether ATRX-deficiency creates a vulnerability in ALT cancer cells that could be exploited for therapeutic purposes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.222349DOI Listing
February 2019
5.432 Impact Factor

[Etiologic surveillance and analysis of acute meningitis and encephalitis syndrome in Jinan city in 2013-2016].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Feb;53(2):174-178

Division of Expanded Immunization Program, Shandong Center for Disease Control and Prevention; Academy of Preventive Medicine, Shandong University; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Jinan 250014, China.

To characterize the etiology and epidemiological characteristics of the acute meningitis and encephalitis syndrome (AMES) in Jinan city in 2013-2016. The epidemiological data, clinical diagnosis, serum and cerebrospinal fluid (CSF) specimens were collected from 3 577 AMES cases in 6 sentinel hospitals in Jinan city in 2013-2016. Samples of all cases were made sero-diagnosis for Immunoglobulin (Ig) M antibody to Japanese encephalitis virus (JEV) and negative cases of JEV for enterovirus (EV), mumps virus (MuV) and herpes simplex virus (HSV) by enzyme-linked immunosorbent assay (ELISA). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.02.010DOI Listing
February 2019
1 Read

Emergency Evaluation and Management of Encephalitis and Myelitis in Adults.

Semin Neurol 2019 Feb 11;39(1):82-101. Epub 2019 Feb 11.

Division of Neuroimmunology and Neuroinfectious Diseases, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Infection of the central nervous system is often a life-threatening emergency. In many cases, the clinician faces an unknown pathogen and must rely upon clinical acumen and a thorough, systematic diagnostic investigation to establish a diagnosis and initiate appropriate treatment. Because patients typically present with a syndrome, such as temporal lobe encephalitis, rather than a known pathogen (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1676845DOI Listing
February 2019
1 Read

[A prognostic value of level of antiviral antibodies in the development of recurrence of bladder cancer].

Urologiia 2018 Dec(6):86-94

Department of Urology and Surgical Andrology of RMANPO, Moscow, Russia.

Introduction: Serological diagnosis of virus-associated tumors attracts the attention of many specialists. The changes in the level of antiviral antibodies in tumors of different localizations are proved. In some cases, the authors suggest using these data either for screening of tumors or for controlling the cure. Read More

View Article

Download full-text PDF

Source
December 2018
1 Read

Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives.

Bioorg Med Chem 2019 Feb 2. Epub 2019 Feb 2.

School of Pharmacy & Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK. Electronic address:

A series of tricyclic penciclovir (PCV) and hydroxybutylguanine (HBG) derivatives have been prepared with enhanced lipophilicity following an efficient synthetic route. All the novel tricyclic derivatives were evaluated for inhibitory activity against herpes simplex virus 1 and 2 (HSV-1, HSV-2) and thymidine kinase deficient (ACV resistant) HSV-1. The tricyclic HBG derivatives were devoid of inhibitory activity however several of the tricyclic PCV derivatives showed promising antiviral activity, in particular 9g (R = 4-MeO-CH) displayed good inhibitory activity (HSV-1 EC 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2019.02.005DOI Listing
February 2019
1 Read

Age-disparate partnerships and HSV-2 among adolescent girls and young women in South Africa: implications for HIV infection risk.

Sex Transm Infect 2019 Feb 8. Epub 2019 Feb 8.

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

Objective: There is an urgent need to understand high HIV-infection rates among young women in sub-Saharan Africa. While age-disparate partnerships have been characterised with high-risk sexual behaviours, the mechanisms through which these partnerships may increase HIV-risk are not fully understood. This study assessed the association between age-disparate partnerships and herpes simplex virus type-2 (HSV-2) infection, a factor known to increase HIV-infection risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/sextrans-2018-053577DOI Listing
February 2019
1 Read

Regulatory mechanisms of the mucin-like region on herpes simplex virus during cellular attachment.

ACS Chem Biol 2019 Feb 8. Epub 2019 Feb 8.

Mucin-like regions, characterized by a local high density of O-linked glycosylation, are found on the viral envelope glycoproteins of many viruses. Herpes simplex virus type 1 (HSV-1), for example, exhibits a mucin-like region on its glycoprotein gC, a viral protein involved in initial recruitment of the virus to the cell surface via interaction with sulfated glycosaminoglycans. So far, this mucin-like region has been proposed to play a key role in modulating the interactions with cellular glycosaminoglycans, and in particular to promote release of HSV-1 virions from infected cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acschembio.9b00064DOI Listing
February 2019
1 Read

A Unique and Rare Case of Extramammary Paget Disease With Concomitant Herpes Simplex.

Am J Dermatopathol 2019 Jan 29. Epub 2019 Jan 29.

Department of Dermatology, National Skin Centre, Singapore.

We describe a rare and unique case of extramammary Paget disease in the genitals with concomitant histological features of herpes virus infection. This is a very rare and interesting association that has only been reported in 1 article in the literature so far. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DAD.0000000000001359DOI Listing
January 2019
2 Reads

Infectious herpes simplex virus in the brainstem is correlated with reactivation in the trigeminal ganglia.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

Cincinnati Children's Hospital Medical Center, Division of Infectious Diseases, 3333 Burnet Avenue, Cincinnati, OH 45229.

Herpes simplex virus (HSV) establishes latency in neurons of the peripheral and central nervous systems (CNS). Evidence is mounting that HSV latency and reactivation in the nervous system has the potential to promote neurodegenerative processes. Understanding how this occurs is an important human health goal. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02209-18DOI Listing
February 2019
1 Read

Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background And Aims: Herpes simplex esophagitis (HSE) is the second most common cause of infectious esophagitis and occurs in both immunocompetent and immunocompromised patients. The aim of this study was to reappraise the clinical course of HSE in different patient populations based on degree of immunocompetence and the presence or absence of underlying esophageal disease.

Methods: Patients with histopathologically confirmed HSE identified from the Mayo Clinic pathology database from 2006 to 2016 were included in this study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10620-019-05493-x
Publisher Site
http://dx.doi.org/10.1007/s10620-019-05493-xDOI Listing
February 2019
3 Reads

Glioblastoma Mimicking Viral Encephalitis Responds to Acyclovir: A Case Series and Literature Review.

Front Oncol 2019 22;9. Epub 2019 Jan 22.

Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience Institute, Seattle, WA, United States.

Viral encephalitis and glioblastoma are both relatively rare conditions with poor prognoses. While the clinical and radiographic presentations of these diseases are often distinctly different, viral encephalitis can sometimes masquerade as glioblastoma. Rarely, glioblastoma can also be misdiagnosed as viral encephalitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350341PMC
January 2019
1 Read

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.

Front Immunol 2019 22;10. Epub 2019 Jan 22.

Institute of Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany.

Robust anti-tumor immunity requires innate as well as adaptive immune responses. We have shown that plasmacytoid dendritic cells develop killer cell-like activity in melanoma cell cocultures after exposure to the infectious but replication-deficient herpes simplex virus 1 (HSV-1) 106S. To combine this innate effect with an enhanced adaptive immune response, the gene encoding human MelanA/MART-1 was inserted into HSV-1 106S via homologous recombination to increase direct expression of this tumor antigen. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00002
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349778PMC
January 2019
3 Reads

Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.

J Infect Dis 2019 Feb 5. Epub 2019 Feb 5.

Centre for Individualized Infection Medicine, Hannover, Germany.

Background: The tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS infections would improve our understanding of pathophysiology and end-organ damage, and, furthermore, open doors to its evaluation as a source of diagnostic and/or prognostic biomarkers.

Methods: We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 220 cerebrospinal fluid samples from patients with bacterial and viral (herpes simplex, varicella zoster, enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (anti-NMDA-R encephalitis, multiple sclerosis), and noninflamed controls (Bell's palsy, normal pressure hydrocephalus, Tourette syndrome). Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/jid/advance-article/doi/10.1093/inf
Publisher Site
http://dx.doi.org/10.1093/infdis/jiz048DOI Listing
February 2019
7 Reads

[Ocular lesions in HIV-infected patients of the ophthalmic hospitals].

Vestn Oftalmol 2018 ;134(6):25-32

Perm State Medical University named after E.A. Wagner, 26 Petropavlovskaya St., Perm, Russian Federation, 614000; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 91 Pervomaiskaya St., Yekaterinburg, Russian Federation, 620041.

Purpose: To analyze ophthalmic pathologies in HIV-infected patients of the ophthalmic hospitals of Perm city.

Material And Methods: Medical records of 75 HIV patients registered in Perm Regional Centre for Prevention and Control of AIDS and Infectious Diseases who had received treatment in ophthalmic in-patient clinics of Perm in 2005-2015 years were analyzed retrospectively. Patient examination included traditional ophthalmological methods, as well as immunological (determination of CD4 cells and viral load), serological (detection of antibodies to herpes simplex virus, cytomegalovirus, chlamydia, toxoplasma), general clinical methods, and consultations by allied specialists. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17116/oftalma201813406125DOI Listing
January 2018
3 Reads

Identification of Putative UL54 (ICP27) Transcription Regulatory Sequences Binding to Oct-1, v-Myb, Pax-6 and Hairy in Herpes Simplex Viruses.

J Cancer 2019 1;10(2):430-440. Epub 2019 Jan 1.

The First School of Clinical Medicine, Department of Medicine, Yangtze University, Jingzhou, Hubei 434023, China.

An oncolytic herpes simplex virus (oHSV) has proven amenable in oncolytic virotherapy and was approved to treat melanoma. The immediate-early (IE) protein ICP27 encoded by gene UL54 is essential for HSV infection. Post-transcriptional modification of UL54 would increase tumor targeting of oHSVs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/jca.29787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360293PMC
January 2019
2 Reads

The Cyclin-Dependent Kinase 5 Inhibitor Peptide Inhibits Herpes Simplex Virus Type 1 Replication.

Sci Rep 2019 Feb 4;9(1):1260. Epub 2019 Feb 4.

Institute of Virology, University of Zurich, Zurich, Switzerland.

In order to evaluate the influence of CDK5 inhibitory peptide (CIP) on Human alphaherpesvirus 1 (HSV-1) replication, we constructed two recombinant adeno-associated-virus 2 (rAAV2) vectors encoding CIP fused with cyan-fluorescent-protein (CFP), with or without nuclear localization signal. A third vector encoding non-fused CIP and CFP was also constructed. HeLa and HEK 293T cells were infected with the rAAV-CIP vectors at multiplicity of infection (MOI) of 5000, in the absence or presence of a recombinant HSV-1 that encodes a yellow-fluorescent-protein (rHSV48Y; MOI = 1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37989-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362106PMC
February 2019

Herpes simplex virus type 1 epidemiology in the Middle East and North Africa: systematic review, meta-analyses, and meta-regressions.

Sci Rep 2019 Feb 4;9(1):1136. Epub 2019 Feb 4.

Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation - Education City, Doha, Qatar.

This study aimed at characterizing herpes simplex virus type 1 (HSV-1) epidemiology in the Middle East and North Africa (MENA). HSV-1 records were systematically reviewed. Findings were reported following the PRISMA guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37833-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362060PMC
February 2019

Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.

Arch Soc Esp Oftalmol 2019 Feb 1. Epub 2019 Feb 1.

Departamento de Oftalmología, Hospital Ramón y Cajal, Madrid, España.

Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. This leads to epithelial defects, ulceration and, eventually, perforation. Both herpes simplex and varicella zoster keratitis are reported to be the main causes of NK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2019.01.002DOI Listing
February 2019
1 Read

Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication.

Cells 2019 Feb 3;8(2). Epub 2019 Feb 3.

The Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.

The primary envelopment/de-envelopment of Herpes viruses during nuclear exit is poorly understood. In Herpes simplex virus type-1 (HSV-1), proteins pUL31 and pUL34 are critical, while pUS3 and some others contribute; however, efficient membrane fusion may require additional host proteins. We postulated that vesicle fusion proteins present in the nuclear envelope might facilitate primary envelopment and/or de-envelopment fusion with the outer nuclear membrane. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8020120DOI Listing
February 2019

Identification of the Epstein Barr Virus portal.

Virology 2019 Jan 10;529:152-159. Epub 2019 Jan 10.

Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA.

Little is known about Epstein Barr Virus (EBV) proteins that participate in viral DNA cleavage and packaging. Genes encoding potential terminase subunit and portal protein homologs include BGRF1/BDRF1, BALF3, BFRF1A and BBRF1 respectively. EBV mutants with deletions in one or more of these genes were impaired for DNA packaging (Pavlova et al. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2019.01.003DOI Listing
January 2019
1 Read

Delivery of different genes into presynaptic and postsynaptic neocortical neurons connected by a BDNF-TrkB synapse.

Brain Res 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans LA 70112, USA; Department of Phamracology, Louisiana State University Health Sciences Center, New Orleans LA 70112, USA. Electronic address:

Brain-Derived Neurotrophic Factor (BDNF) signaling through TrkB receptors has important roles in synapse formation, synaptic plasticity, learning, and specific diseases. However, it is challenging to relate BDNF-TrkB synapses to circuit physiology or learning, as BDNF-TrkB synapses are embedded in complex circuits that contain numerous neuron and synapse types. Thus, analyzing the physiology of neurons connected by BDNF-TrkB synapses would be advanced by a technology to deliver different genes into presynaptic and postsynaptic neurons, connected by a BDNF-TrkB synapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brainres.2019.01.038DOI Listing
January 2019
1 Read

Prevalence, Change Over Time, and Comparison With U.S. Estimates of Selected Infectious Diseases in Los Angeles County: Findings From the National Health and Nutrition Examination Survey, 1999-2006 and 2007-2014.

Natl Health Stat Report 2018 Oct(119):1-17

Objective-This report compares prevalence of and change over time for five infectious disease outcomes for the Los Angeles County (LAC) and the U.S. populations. Read More

View Article

Download full-text PDF

Source
October 2018
2 Reads

Construction of Oncolytic Herpes Simplex Virus with Therapeutic Genes of Interest.

Methods Mol Biol 2019 ;1937:177-188

Department of Neurosurgery, Brain Tumor Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Herpes simplex virus (HSV) is one of the most extensively studied oncolytic virus platforms. The recent FDA approval of talimogene laherparepvec (T-VEC) has been accelerating translational research of oncolytic HSV (oHSV) as a promising therapeutic for refractory cancers such as glioblastoma, the deadliest primary malignancy in the brain. The large genome size of HSV readily allows arming of oHSV by incorporating therapeutic transgenes within the virus, as exemplified by T-VEC carrying GM-CSF, thereby enhancing the anticancer activity of oHSV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9065-8_10DOI Listing
January 2019

Basic Concepts in Viral Vector-Mediated Gene Therapy.

Methods Mol Biol 2019 ;1937:3-26

Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, MI, USA.

Today any researcher with the desire can easily purchase a viral vector. However, despite the availability of viral vectors themselves, the requisite knowledge that is absolutely essential to conducting a gene therapy experiment remains somewhat obscure and esoteric. To utilize viral vectors to their full potential, a large number of decisions must be made, in some instances prior to even obtaining the vector itself. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-9065-8_1DOI Listing
January 2019