Search our Database of Scientific Publications and Authors

I’m looking for a

    48097 results match your criteria Herpes Simplex

    1 OF 962

    Cytoplasmic Translocation of Nucleolar Protein NOP53 Promotes Viral Replication by Suppressing Host Defense.
    Viruses 2018 Apr 20;10(4). Epub 2018 Apr 20.
    Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
    NOP53 is a tumor suppressor protein located in the nucleolus and is translocated to the cytoplasm during infection by vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1), as shown in our previous study. Cytoplasmic NOP53 interacts with the retinoic acid-inducible gene I (RIG-I) to remove its K63-linked ubiquitination, leading to attenuation of type I interferon IFN-β. In the present study, we found no obvious translocation of NOP53 in infection by a mutant virus lacking ICP4 (HSV-1/d120, replication inadequate). Read More

    Bilateral herpes simplex keratitis reactivation after lacrimal gland botulinum toxin injection.
    Indian J Ophthalmol 2018 May;66(5):697-699
    Cornea Services, LJ Eye Institute, Ambala, Haryana, India.
    Botulinum toxin A (BTA) injections into lacrimal gland are being used for refractory epiphora due to intractable lacrimal disorders with success rates reported from 18% to 86%. Most common side effects are transient ptosis and diplopia. We report a case of a 59-year-old female injected with 2. Read More

    Rapid multiplex nucleic acid amplification test developed using paper chromatography chip and azobenzene-modified oligonucleotides.
    J Biosci Bioeng 2018 Apr 16. Epub 2018 Apr 16.
    Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8530, Japan.
    Although nucleic acid amplification test (NAT) is widely used for pathogen detection, rapid NAT systems that do not require special and expensive instruments must be developed in order to enable point of care (POC)-NATs, which contribute to early initiation of treatment. As a POC-NAT system, Kaneka DNA chromatography chip (KDCC), developed using DNA tag-bound primer through modified substance, was shown to be suitable for POC testing, due to the rapid detection time, simple procedures, and low manufacturing costs. However, owing to some modifications in primer, the detection performance and amplification speed were shown to be reduced when using KDCC, counteracting the increased speed of detection. Read More

    Concepts in Light Microscopy of Viruses.
    Viruses 2018 Apr 18;10(4). Epub 2018 Apr 18.
    Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
    Viruses threaten humans, livestock, and plants, and are difficult to combat. Imaging of viruses by light microscopy is key to uncover the nature of known and emerging viruses in the quest for finding new ways to treat viral disease and deepening the understanding of virus–host interactions. Here, we provide an overview of recent technology for imaging cells and viruses by light microscopy, in particular fluorescence microscopy in static and live-cell modes. Read More

    Comparative Analysis of Mutants Derived from Multiple Strains of HSV-2 and HSV-1 Reveals Species-Specific Requirements for the UL16 Protein.
    J Virol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada K7L 3N6.
    Orthologs of the herpes simplex virus (HSV) gene are conserved throughout the Because of this conservation, one might expect that these proteins perform similar functions for all herpesviruses. Previous studies on a null mutant derived from HSV-2 strain 186 revealed a roughly 100-fold replication defect and a critical role for UL16 in the nuclear egress of capsids. These findings were in stark contrast to what has been observed with mutants of HSV-1 and pseudorabies virus where roughly 10-fold replication deficiencies were reported that were accompanied by defects in the secondary envelopment of cytoplasmic capsids. Read More

    BHV-1 U49.5 interacts with gM and VP22 to ensure virus cell-to-cell spread and virion incorporation: A novel role for VP22 in gM independent U49.5 virion incorporation.
    J Virol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803.
    Alphaherpesvirus envelope glycoprotein N (gN) and gM form a covalently linked complex. Bovine herpesvirus type 1 (BHV-1) U49.5 (a gN homolog) contains two predicted cysteine residues C42 and C78. Read More

    Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis.
    Inflamm Bowel Dis 2018 Apr 13. Epub 2018 Apr 13.
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
    Background: Little is known about the prevalence and pathogenicity of human herpes viruses except for cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of human herpes viruses on colonic mucosa in patients with IBD and assess the long-term outcomes in these patients.

    Methods: We examined the colonic mucosal specimens from 66 patients with ulcerative colitis (UC), 54 patients with Crohn's disease (CD), and 29 healthy patients to identify the 6 most common types of human herpes virus, using multiplex polymerase chain reaction (PCR) technique. Read More

    Seroprevalence of herpes simplex virus types 1 and 2 among pregnant women and sexually active, non-pregnant women in the United States.
    Clin Infect Dis 2018 Apr 16. Epub 2018 Apr 16.
    Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
    Background: Neonatal herpes is a rare, devastating consequence of herpes simplex virus type 1 (HSV-1) or 2 (HSV-2) infection during pregnancy. The risk of neonatal infection is higher among pregnant women seronegative for HSV-1 or HSV-2 who acquire their first HSV infection near delivery.

    Methods: We estimated HSV-1 and HSV-2 seroprevalence among pregnant women aged 20-39 years in 1999-2014, assessed HSV seroprevalence changes between 1999-2006 and 2007-2014, and compared HSV seroprevalence between pregnant women and sexually active, non-pregnant women aged 20-39 years in 2007-2014 using National Health and Nutrition Examination Survey data. Read More

    Questioning the Extreme Neurovirulence of Monkey B Virus .
    Adv Virol 2018 13;2018:5248420. Epub 2018 Feb 13.
    Department of Anthropology and Center for Studies in Ecology and Demography, University of Washington, Seattle, WA 98195, USA.
    Monkey B virus ( 1; BV) occurs naturally in macaques of the genus which includes rhesus and long-tailed (cynomolgus) monkeys that are widely used in biomedical research. BV is closely related to the human herpes simplex viruses (HSV), and BV infections in its natural macaque host are quite similar to HSV infections in humans. Zoonotic BV is extremely rare, having been diagnosed in only a handful of North American facilities with the last documented case occurring in 1998. Read More

    Zika Virus IgG in Infants with Microcephaly, Guinea-Bissau, 2016.
    Emerg Infect Dis 2018 May;24(5):948-950
    We analyzed blood samples from infants born with microcephaly and their mothers in Guinea-Bissau in 2016 for pathogens associated with birth defects. No Zika virus RNA was detected, but Zika virus IgG was highly prevalent. We recommend implementing pathogen screening of infants with congenital defects in Guinea-Bissau. Read More

    A Glimpse into Uveitis in the Aging Eye: Pathophysiology, Clinical Presentation and Treatment Considerations.
    Drugs Aging 2018 Apr 16. Epub 2018 Apr 16.
    University of Miami Miller School of Medicine, Miami, FL, USA.
    Uveitis describes a group of inflammatory conditions of the eye that have various underlying causes and clinical presentations. Susceptibilities to uveitis in the elderly may be attributed to age-related risk factors such as immunosenescence, increased immunological inflammatory mediators, and autoimmunity. Overall, anterior uveitis is more common than posterior and panuveitis in the general population and also in the elderly. Read More

    Importin-β and exportin-5 are indicators of acute viral infection: Correlation of their detection with commercially available detection kits.
    Ann Diagn Pathol 2018 Jan 10;34:36-41. Epub 2018 Jan 10.
    Evandro Chagas National Institute of Infectious Diseases, and Laboratory of Interdisciplinary Medical Research (LIPMED), IOC, Rio de Janeiro, Brazil.
    This work focused on immunohistochemistry markers of acute viral infections. Viral infected cells were detected by in situ based methods (reovirus, rabies virus) or cytologic changes (human papillomavirus, molloscum contagiosum virus, herpes simplex virus). Two proteins involved in nuclear trafficking, importin-β and exportin-5, were detected in the infected cells for each virus and not in the control tissues. Read More

    Sexually Transmitted Bedfellows: Exquisite Association between HIV and HSV2 in 21 Communities in Southern Africa in the HPTN 071 (PopART) Study.
    J Infect Dis 2018 Apr 6. Epub 2018 Apr 6.
    MRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, United Kingdom.
    Background: HIV and Herpes simplex virus type-2 (HSV2) are strongly associated, although mechanisms are not fully understood. An HIV prevention trial allowed re-examination of this association at individual and community levels.

    Methods: HPTN 071 (PopART) evaluates a combination prevention intervention in 21 urban communities in Zambia and South Africa. Read More

    A Novel Oncolytic Herpes Capable of Cell-Specific Transcriptional Targeting of CD133± Cancer Cells Induces Significant Tumor Regression.
    Stem Cells 2018 Apr 15. Epub 2018 Apr 15.
    Midwest Biomedical Research Foundation, Kansas City Veterans Affairs Medical Center, Kansas City, MO, USA.
    The topic of cancer stem cells is of significant importance due to its implications in our understanding of the tumor biology, as well as the development of novel cancer therapeutics. However, the question of whether targeting cancer stem cells can hamper the growth of tumors remains mainly unanswered due to the lack of specific agents for this purpose. In order to address this issue, we have developed the first mutated version of herpes simplex virus-1 (HSV-1) that is transcriptionally targeted against CD133+ cells. Read More

    Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responses.
    Vaccine 2018 Apr 11. Epub 2018 Apr 11.
    Department of Pathobiological Sciences and Division of Biotechnology and Molecular Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address:
    Herpes simplex virus is a common causative agent of oral and genital diseases. Novel vaccines and therapeutics are needed to combat herpes infections especially after the failure of subunit vaccines in human clinical trials. We have shown that the live-attenuated HSV-1 VC2 vaccine strain is unable to establish latency in vaccinated animals and produces a robust immune response capable of completely protecting mice against lethal vaginal HSV-1 or HSV-2 infections. Read More

    Cerebrospinal Fluid Concentrations of Biogenic Amines: Potential Biomarkers for Diagnosis of Bacterial and Viral Meningitis.
    Pathogens 2018 Apr 13;7(2). Epub 2018 Apr 13.
    Department of Microbiology, University of Karachi, Karachi 75270, Pakistan.
    Catecholamine and serotonin are biogenic amines (BAs) that serve as neurotransmitters and play an important role in the regulation of cardinal functions that are mainly altered during central nervous system (CNS) infections. A total 92 samples of cerebrospinal fluid (CSF) were classified into 4 groups based on their etiology. In these samples, BAs/neurotransmitters i. Read More

    CHAPTER 2 The epidemiology of human papillomavirus infection and its association with cervical cancer.
    Int J Gynaecol Obstet 2006 Nov;94 Suppl 1:S8-S21
    Cervical cancer has been recognized as a rare outcome of a common, sexually transmitted infection whose etiologic association is restricted to a few human papillomavirus (HPV) types. With optimal testing systems HPV DNA can be identified in nearly all specimens of invasive cervical cancer, and it is claimed that infection of the cervix with HPV is a necessary cause of cervical cancer. The evidence is consistent worldwide for squamous cell carcinomas (SCC), adenocarcinomas, and the vast majority (>95%) of the immediate cervical cancer precursors, namely high-grade squamous intraepithelial lesions (HSILs)-also known as cervical intraepithelial neoplasia 3 (CIN 3) or carcinoma in situ. Read More

    Neuronal subtype determines HSV-1 Latency-Associated-Transcript (LAT) promoter activity during latency.
    J Virol 2018 Apr 11. Epub 2018 Apr 11.
    Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
    Herpes simplex virus (HSV) latency in neurons remains poorly understood, and the heterogeneity of the sensory nervous system complicates mechanistic studies. In this study, we used primary culture of adult trigeminal ganglion (TG) mouse neurons in microfluidic devices, and an model, to examine the subtypes of sensory neurons involved in HSV latency. HSV-infected neurofilament heavy-positive neurons (NefH) were more likely to express Latency-Associated Transcripts (LATs) relative to infected neurofilament heavy-negative neurons (NefH). Read More

    Cholangiocarcinoma: molecular imaging-guided radiofrequency hyperthermia-enhanced intratumoral herpes simplex virus thymidine kinase gene therapy.
    Am J Cancer Res 2018 1;8(3):502-513. Epub 2018 Mar 1.
    Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of MedicineHangzhou, Zhejiang, China.
    We investigated the feasibility of using radiofrequency hyperthermia (RFH) to enhance green fluorescent protein (GFP)/herpes simplex virus thymidine kinase (HSV-TK)/ganciclovir (GCV) gene therapy of cholangiocarcinoma. Cholangiocarcinoma cells and mice with cholangiocarcinoma were treated by (i) GFP/HSV-TK/plasmid combined with RFH at 42°C, followed by ganciclovir administration; (ii) HSV-TK alone; (iii) RFH alone; and (iv) saline. The therapeutic effects among different treatments were evaluated by bioluminescent optical imaging and ultrasound imaging. Read More

    From HSV infection to erythema multiforme through autoimmune crossreactivity.
    Autoimmun Rev 2018 Apr 7. Epub 2018 Apr 7.
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania 'Luigi Vanvitelli', Via de Crecchio 6, 80138 Naples, Italy. Electronic address:
    Scientific and clinical data indicate that human herpes simplex virus 1 (HSV1) and, at a lesser extent, human herpes simplex virus 2 (HSV2) are factor(s) implicated in the development of erythema multiforme (EM). With a focus on oral EM, the present structured review of proteomic and epitope databases searched for the molecular basis that might link HSV1 and HSV2 infections to EM. It was found that a high number of peptides are shared between the two HSVs and human proteins related to the oral mucosa. Read More

    Herpesvirus Infection in Infants with Gastroschisis.
    Epidemiology 2018 Apr 6. Epub 2018 Apr 6.
    Background: Gastroschisis is a congenital malformation that has been shown to be more common in younger mothers and appears to be increasing in prevalence in the United States and elsewhere. Epidemiologic data suggest a potential role of infection and recent studies report an association between maternal antibodies to human herpesviruses (HHV) and development of gastroschisis.

    Methods: In this study we examined newborn bloodspots from 50 children with gastroschisis and 50 healthy controls using a highly sensitive digital droplet polymerase chain reaction assay covering eight human herpesviruses (Herpes Simplex Virus 1/2, Epstein-Barr virus (HHV-4), cytomegalovirus (HHV-5), HHV-6A/B, HHV-7, and HHV-8), to examine the presence of herpesvirus DNA at birth, which would suggest in utero infection. Read More

    Compound heterozygous mutations in desmoplakin associated with skin fragility, follicular hyperkeratosis, alopecia, and nail dystrophy.
    Pediatr Dermatol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, School of Medicine, Indiana University, Indianapolis, IN, USA.
    Desmoplakin mutations are associated with a wide variety of phenotypes affecting the skin, nails, hair, and heart. A 21-month-old boy was born with multiple erosions resembling epidermolysis bullosa, complete alopecia, nail dystrophy, palmoplantar keratoderma, and areas of follicular hyperkeratosis. He was found to have two heterozygous mutations in the desmoplakin gene: c. Read More

    Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner.
    Nat Microbiol 2018 Apr 9. Epub 2018 Apr 9.
    Howard Hughes Medical Institute, New Haven, CT, USA.
    Antibiotics are widely used to treat infections in humans. However, the impact of antibiotic use on host cells is understudied. Here we identify an antiviral effect of commonly used aminoglycoside antibiotics. Read More

    Behçet's disease: New insights into pathophysiology, clinical features and treatment options.
    Autoimmun Rev 2018 Apr 6. Epub 2018 Apr 6.
    Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100 Rome, Italy. Electronic address:
    Behçet's disease (BD) is a rare systemic vasculitis characterized by oral aphthous ulcers, genital ulcers, ocular lesions and other systemic manifestations. BD occurs most frequently in Eurasian populations along the ancient trading route known as the "Silk Road" which extends from eastern Asia to the Mediterranean basin. The causes of BD are unknown: it is believed to be due to an autoimmune process triggered by an infectious or environmental agent in a genetically predisposed individual. Read More

    Anti-NMDA receptor encephalitis and nonencephalitic HSV-1 infection.
    Neurol Neuroimmunol Neuroinflamm 2018 Jul 5;5(4):e458. Epub 2018 Apr 5.
    Division of Neurology (A.S., J.G., K.R., D.R.L., J.A.P.), Department of Pediatrics, Children's Hospital of Philadelphia, PA; Clinical and Experimental Neuroimmunology Program (T.A.), August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Hospital Clínic, University of Barcelona; Pediatric Neuroimmunology Unit (T.A.), Department of Neurology, Sant Joan de Deu Childrens Hospital, University of Barcelona, Spain; and Department of Neurology (D.R.L., J.A.P.), Perelman School of Medicine, University of Pennsylvania, PA.
    Objective: To determine whether there is an association between nonencephalitic herpes simplex virus 1 (HSV-1) infection and anti-NMDA receptor encephalitis (anti-NMDARE).

    Methods: Antibody testing was performed using samples from 2 cohorts in a case-control observational study. The cohort "Philadelphia" included 16 serum samples of pediatric anti-NMDARE cases and 42 age-matched controls with other neuroinflammatory disorders studied at the Children's Hospital of Philadelphia and University of Pennsylvania. Read More

    Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome associated with cefotaxime and clindamycin use in a 6 year-old boy: a case report.
    Pan Afr Med J 2017 9;28:218. Epub 2017 Nov 9.
    Healthy Sciences University, Umraniye Training and Research Hospital, Department of Pediatrics, Istanbul, Turkey.
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially life-threatening idiosyncratic drug reaction. It presents with extensive rash, fever, lymphadenopathy, hematologic abnormalities (eosinophilia and/or atypical lymphocytosis) and internal organ involvement. It has been described in association with more than 50 drugs. Read More

    Acute encephalitis - diagnosis and management.
    Clin Med (Lond) 2018 Mar;18(2):155-159
    The Walton Centre NHS Foundation Trust, Liverpool, UK.
    Encephalitis, inflammation of the brain, is most commonly caused by a viral infection (especially herpes simplex virus [HSV] type 1 in the UK) although autoimmune causes, such as N-methyl D-aspartate receptor (NMDAR) antibody encephalitis, are increasingly recognised. Most patients present with a change in consciousness level and may have fever, seizures, movement disorder or focal neurological deficits. Diagnosis hinges crucially on lumbar puncture and cerebrospinal fluid (CSF) examination, but imaging and electroencephalography (EEG) may also be helpful. Read More

    Review of mathematical models of HSV-2 vaccination: Implications for vaccine development.
    Vaccine 2018 Apr 3. Epub 2018 Apr 3.
    Department of Infectious Diseases Epidemiology, Imperial College London, UK.
    Development of a vaccine against herpes simplex virus type 2 (HSV-2), a life-long sexually-transmitted infection (STI), would be a major step forward in improving global sexual and reproductive health. In this review, we identified published literature of dynamic mathematical models assessing the impact of either prophylactic or therapeutic HSV-2 vaccination at the population level. We compared each study's model structure and assumptions as well as predicted vaccination impact. Read More

    Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II.
    Invest Ophthalmol Vis Sci 2018 Mar;59(3):1512-1522
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
    Purpose: To explore the impact of ocular surface insults on the immunomodulatory capacity and phenotype of corneal epithelial cells (CECs) with a focus on epithelial-mesenchymal transition (EMT).

    Methods: Corneas were harvested from mice 6 days following scratch injury, ragweed pollen-induced allergy, or herpes simplex virus type 1 (HSV-1) infection and compared to healthy tissue controls. Corneas were enzymatically digested and CECs phenotypically characterized using flow cytometry. Read More

    Effects of cationic liposomes with stearylamine against virus infection.
    Int J Pharm 2018 Apr 3;543(1-2):311-317. Epub 2018 Apr 3.
    Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Gifu, Japan. Electronic address:
    In this study, we demonstrated that cationic liposomes with incorporated stearylamine (SA) inhibit viral infectivity without preloaded active pharmaceutical ingredients. Specifically, we correlated physiochemical properties of liposomes, such as zeta potentials and particle sizes, with virus infectivity using the BacMam™ reagent, which is based on recombinant baculovirus (BV). Compared with neutral or negatively-charged liposomes, SA liposomes suppressed BV infectivity in several mammalian cell lines, including A549 cells. Read More

    HSV infection is associated with gestational hypertension: results from the US National inpatient sample.
    J Investig Med 2018 Apr 4. Epub 2018 Apr 4.
    Department of Endocrinology, NO.117 Center Military Hospital, Hangzhou, China.
    The purpose of this study was to determine if there is an association between maternal herpes simplex virus (HSV) infection and pre-eclampsia/eclampsia or gestational hypertension. The US Nationwide Inpatient Sample database was searched for women aged 15-44 years who delivered in a hospital between 2005 and 2014. The patients were categorized into those with and without HSV and pre-eclampsia/eclampsia and gestational hypertension were compared between the groups. Read More

    Secular Trends in Infection-Related Mortality after Kidney Transplantation.
    Clin J Am Soc Nephrol 2018 Apr 5. Epub 2018 Apr 5.
    Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland; and
    Background And Objectives: Infections are the most common noncardiovascular causes of death after kidney transplantation. We analyzed the current infection-related mortality among kidney transplant recipients in a nationwide cohort in Finland.

    Design, Setting, Participants, & Measurements: Altogether, 3249 adult recipients of a first kidney transplant from 1990 to 2012 were included. Read More

    Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes.
    Science 2018 04 5;360(6384). Epub 2018 Apr 5.
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
    Herpes simplex viruses (HSVs) rely on capsid-associated tegument complex (CATC) for long-range axonal transport of their genome-containing capsids between sites of infection and neuronal cell bodies. Here we report cryo-electron microscopy structures of the HSV-1 capsid with CATC up to 3.5-angstrom resolution and atomic models of multiple conformers of capsid proteins VP5, VP19c, VP23, and VP26 and tegument proteins pUL17, pUL25, and pUL36. Read More

    Cryo-EM structure of a herpesvirus capsid at 3.1 Å.
    Science 2018 04;360(6384)
    National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
    Structurally and genetically, human herpesviruses are among the largest and most complex of viruses. Using cryo-electron microscopy (cryo-EM) with an optimized image reconstruction strategy, we report the herpes simplex virus type 2 (HSV-2) capsid structure at 3.1 angstroms, which is built up of about 3000 proteins organized into three types of hexons (central, peripentonal, and edge), pentons, and triplexes. Read More

    Increasing antigen presentation on HSV-1-infected cells increases lesion size but does not alter neural infection or latency.
    J Gen Virol 2018 Apr 5. Epub 2018 Apr 5.
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
    CD8 T cells have a role in the control of acute herpes simplex virus (HSV) infection and may also be important in the maintenance of latency. In this study we have explored the consequences of boosting the efficacy of CD8 T cells against HSV by increasing the amount of an MHC I-presented epitope on the surface of infected cells. To do this we used HSVs engineered to express an extra copy of the immunodominant CD8 T cell epitope in C57Bl/6 mice, namely gB498 (SSIEFARL). Read More

    Prevalence of Sexually Transmitted Diseases in Asymptomatic Renal Transplant Recipients.
    Exp Clin Transplant 2018 Apr 4. Epub 2018 Apr 4.
    From the Department of Urology, Altinbas University, Istanbul, Turkey.
    Objectives: Sexually transmitted diseases, which may be asymptomatic, have the potential to cause serious health problems in renal transplant recipients. The aim of this study was to determine the prevalence of sexually transmitted diseases in sexually active asymptomatic renal transplant patients by using real-time multiplex polymerase chain reaction assays.

    Materials And Methods: This prospective controlled study was conducted between November 2016 and January 2017 in our hospital. Read More

    Functional relevance of the transmembrane domain and cytoplasmic tail of the pseudorabies virus glycoprotein H for membrane fusion.
    J Virol 2018 Apr 4. Epub 2018 Apr 4.
    Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany
    Herpesvirus membrane fusion depends on the core fusion machinery comprising glycoproteins (g)B and gH/gL. Although gB structurally resembles autonomous class III fusion proteins, it strictly depends on gH/gL to drive membrane fusion. Whether the gH/gL complex needs to be membrane-anchored to fulfill its function and which role the gH cytoplasmic (CD) and transmembrane domains (TMD) play in fusion is unclear. Read More

    Non-mumps Viral Parotitis During the 2014-2015 Influenza Season in the United States.
    Clin Infect Dis 2018 Mar 30. Epub 2018 Mar 30.
    Bureau of Communicable Diseases, Wisconsin Division of Public Health, Madison.
    Background: During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence.

    Methods: NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result. Read More

    Trends in the relative prevalence of genital ulcer disease pathogens and association with HIV infection in Johannesburg, South Africa, 2007-2015.
    PLoS One 2018 4;13(4):e0194125. Epub 2018 Apr 4.
    Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
    Background: In South Africa, treatment of genital ulcer disease (GUD) occurs in the context of syndromic management. GUD aetiological studies have been conducted in Johannesburg since 2007. We report on GUD pathogen prevalence, sero-prevalence of STI co-infections and aetiological trends among GUD patients presenting to a community-based primary healthcare facility in Johannesburg over a 9-year period. Read More

    Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer's Disease.
    Front Neurol 2018 19;9:145. Epub 2018 Mar 19.
    LSU Neuroscience Center, Louisiana State University Health Sciences Center New Orleans, New Orleans, LA, United States.
    The first indication of a potential mechanistic link between the pathobiology of the human gastrointestinal (GI)-tract microbiome and its contribution to the pathogenetic mechanisms of sporadic Alzheimer's disease (AD) came a scant 4 years ago (1). Ongoing research continues to strengthen the hypothesis that neurotoxic microbial-derived components of the GI tract microbiome can cross aging GI tract and blood-brain barriers and contribute to progressive proinflammatory neurodegeneration, as exemplified by the AD-process. Of central interest in these recent investigations are the pathological roles played by human GI tract resident Gram-negative anaerobic bacteria and neurotropic viruses-two prominent divisions of GI tract microbiome-derived microbiota-which harbor considerable pathogenic potential. Read More

    Imaging, Tracking and Computational Analyses of Virus Entry and Egress with the Cytoskeleton.
    Viruses 2018 03 31;10(4). Epub 2018 Mar 31.
    Department of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
    Viruses have a dual nature: particles are “passive substances” lacking chemical energy transformation, whereas infected cells are “active substances” turning-over energy. How passive viral substances convert to active substances, comprising viral replication and assembly compartments has been of intense interest to virologists, cell and molecular biologists and immunologists. Infection starts with virus entry into a susceptible cell and delivers the viral genome to the replication site. Read More

    Multiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growth.
    Proc Natl Acad Sci U S A 2018 Apr 2;115(16):E3808-E3816. Epub 2018 Apr 2.
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE-751 23 Uppsala, Sweden;
    The zinc finger CCCH-type containing 11A () gene encodes a well-conserved zinc finger protein that may function in mRNA export as it has been shown to associate with the transcription export (TREX) complex in proteomic screens. Here, we report that ZC3H11A is a stress-induced nuclear protein with RNA-binding capacity that localizes to nuclear splicing speckles. During an adenovirus infection, the ZC3H11A protein and splicing factor SRSF2 relocalize to nuclear regions where viral DNA replication and transcription take place. Read More

    STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice.
    PLoS Pathog 2018 Apr 2;14(4):e1006976. Epub 2018 Apr 2.
    Department of Biomedicine, Aarhus University, Denmark.
    In recent years, there has been an increasing interest in immunomodulatory therapy as a means to treat various conditions, including infectious diseases. For instance, Toll-like receptor (TLR) agonists have been evaluated for treatment of genital herpes. However, although the TLR7 agonist imiquimod was shown to have antiviral activity in individual patients, no significant effects were observed in clinical trials, and the compound also exhibited significant side effects, including local inflammation. Read More

    Understanding Primate Herpesviruses.
    J Emerg Dis Virol 2017 Mar 31;3(1). Epub 2017 Jan 31.
    Department of Anthropology and Center for Studies in Demography and Ecology, University of Washington, Washington, USA.
    Viruses related to the herpes simplex viruses of humans are present in all nonhuman primate (NHP) species tested and cross species transmission has been documented. The herpesvirus present in macaques, Herpes B virus (BV) rarely causes disease in its natural macaque host. However, when transmitted to a nonnative host, BV has occasionally caused severe and even fatal disease if not treated immediately. Read More

    Genomic, Recombinational and Phylogenetic Characterization of Global Feline Herpesvirus 1 Isolates.
    Virology 2018 May 30;518:385-397. Epub 2018 Mar 30.
    McPherson Eye Research Institute, University of Wisconsin-Madison, Wisconsin, USA; Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Wisconsin, USA; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Wisconsin, USA. Electronic address:
    Feline herpes virus type 1 (FHV-1) is widely considered to be the leading cause of ocular disease in cats and has been implicated in upper respiratory tract infections. Little, however is known about interstrain phylogenetic relationships, and details of the genomic structure. For the present study, twenty-six FHV-1 isolates from different cats in animal shelters were collected from eight separate locations in the USA, and the genomes sequenced. Read More

    Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2.
    Virology 2018 May 28;518:349-357. Epub 2018 Mar 28.
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, USA 77555; Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, USA 77555; Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas, USA 77555. Electronic address:
    Genital herpes infection in guinea pigs closely models human infection but tools for immune characterization are limited. Immunity to HSV infection at the vaginal epithelial surface was characterized in guinea pigs using PCR-based array analysis of vaginal swab samples. IFNγ was one of the most significantly upregulated genes throughout the infection and over 40% of genes with significantly altered expression were linked to IFNγ based on INTERFEROME analysis. Read More

    Study on antiviral activities, drug-likeness and molecular docking of bioactive compounds of Punica granatum L. to Herpes simplex virus - 2 (HSV-2).
    Microb Pathog 2018 Mar 28;118:301-309. Epub 2018 Mar 28.
    Centre for Drug Design, Discovery and Development (C4D), SRM University, Delhi - NCR, Sonepat 131029, Haryana, India. Electronic address:
    Herpes simplex virus - 2 (HSV-2) causes lifelong persisting infection in the immunocompromised host and intermittent in healthy individuals with high morbidity in neonatals and also increase the transmission of HIV. Acyclovir is widely used drug to treat HSV-2 infection but it unable to control viral latency and recurrent infection and prolonged usage lead to drug resistance. Plant-based bioactive compounds are the lead structural bio-molecules play an inevitable role as a potential antiviral agent with reduced toxicity. Read More

    1 OF 962