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    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 Apr 21:1-9. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    A critical appraisal of 'Shingrix', a novel Herpes Zoster Subunit (HZ/Su or GSK1437173A) vaccine for Varicella Zoster Virus.
    Hum Vaccin Immunother 2017 Apr 20. Epub 2017 Apr 20.
    c University College London , London , United Kingdom.
    HZ/Su, branded as 'Shingrix', is one of the newest vaccines to be submitted for multi-national regulatory approval. It is targeted to prevent shingles, predominantly affecting the elderly, but a global concern with ageing populations and significant associated morbidity and mortality. A vaccine for shingles has been available for over a decade, however it is contraindicated in specific subgroups of people, and there are added concerns regarding long-term immunogenicity. Read More

    Pitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial.
    Lancet HIV 2017 Apr 13. Epub 2017 Apr 13.
    AIDS Research Consortium of Atlanta, Atlanta, GA, USA.
    Background: People living with HIV-1 infection are at greater risk for cardiovascular disease than seronegative adults. Treatment of dyslipidaemia with statins has been challenging in people with HIV because of an increased potential for drug interactions due to competing cytochrome P450 metabolism between statins and commonly used antiretroviral agents. Neither pitavastatin nor pravastatin depend on cytochrome P450 for primary metabolism. Read More

    New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1.
    Bioorg Med Chem Lett 2017 Apr 1. Epub 2017 Apr 1.
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russian Federation.
    Using the enzymatic transglycosylation reaction β-d-ribo- and 2'-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have been synthesized. 2-Amino-5,6-difluoro-benzimidazole riboside proved to exhibit a selective antiviral activity (selectivity index >32) against a wild strain of the herpes simplex virus type 1, as well as towards virus strains that are resistant to acyclovir, cidofovir, and foscarnet. We believe that this compound might be used for treatment of herpes infections in those cases, when acyclovir is not efficient. Read More

    An overview application of silver nanoparticles in inhibition of herpes simplex virus.
    Artif Cells Nanomed Biotechnol 2017 Apr 12:1-5. Epub 2017 Apr 12.
    k Biotechnology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
    Nanoscale particles and molecules are a potential different for the treatment of disease because they have distinctive biologic property based on their structure and size, which is different from traditional small-molecule drugs. The antimicrobial mechanisms of silver nanoparticles include the formation of free radicals damaging the bacterial membranes, interactions with DNA, adhesion to cell surface altering the membrane properties, and enzyme damage. In this review, we focus on applications of silver nanoparticles in inhibition of herpes simplex virus. Read More

    Enhanced acyclovir delivery using w/o type microemulsion: preclinical assessment of antiviral activity using murine model of zosteriform cutaneous HSV-1 infection.
    Artif Cells Nanomed Biotechnol 2017 Apr 12:1-9. Epub 2017 Apr 12.
    a Division of Pharmaceutics, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University , Chandigarh , India.
    The present study was aimed to develop and evaluate a microemulsion-based dermal drug delivery of an antiviral agent, acyclovir. A water-in-oil microemulsion was prepared using isopropyl myristate, Tween 20, Span 20, water and dimethylsulphoxide. It was characterized for drug content, stability, globule size, pH, viscosity and ex vivo permeation through mice skin. Read More

    Primary effusion lymphoma: current concepts and management.
    Curr Opin Pulm Med 2017 Apr 8. Epub 2017 Apr 8.
    aDepartment of Internal Medicine bDivision of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
    Purpose Of Review: To summarize the current epidemiology, management, and outcomes of primary effusion lymphoma (PEL) and highlight possible future research efforts.

    Recent Findings: Cyclophosphamide, doxorubicin, vincristine, prednisone-based chemotherapy regimens alone or in combination with immunomodulatory agents (e.g. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Apr 11:1-9. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    HHV8/KSHV-Positive Lymphoproliferative Disorders and the Spectrum of Plasmablastic and Plasma Cell Neoplasms: 2015 SH/EAHP Workshop Report-Part 3.
    Am J Clin Pathol 2017 Feb;147(2):171-187
    University of Leeds, Leeds, UK.
    Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review immunodeficiency-related lymphoproliferative disorders with plasmablastic and plasma cell differentiation.

    Methods: The workshop panel reviewed human herpes virus 8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV)-associated lesions and other lesions exhibiting plasma cell differentiation, including plasmablastic proliferations with features of myeloma/plasmacytoma, plasmablastic neoplasms presenting in extranodal sites and effusion-based lymphomas, and rendered a consensus diagnosis.

    Results: The spectrum of HHV8/KSHV-associated proliferations ranged from multicentric Castleman disease (MCD) to MCD with plasmablastic aggregates to HHV8+ diffuse large B-cell lymphoma and germinotrophic lymphoproliferative disorder. Read More

    Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.
    Biochem Pharmacol 2017 Apr 6. Epub 2017 Apr 6.
    Department of Chemistry, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland; School of Pharmacy, Analytical and Biological Chemistry Research Facility, Synthesis and Solid State Pharmaceutical Centre, University College Cork, Ireland.
    α-Carboxy nucleoside phosphonates (α-CNPs) are modified nucleotides that represent a novel class of nucleotide-competing reverse transcriptase (RT) inhibitors (NcRTIs). They were designed to act directly against HIV-1 RT without the need for prior activation (phosphorylation). In this respect, they differ from the nucleoside or nucleotide RTIs [N(t)RTIs] that require conversion to their triphosphate forms before being inhibitory to HIV-1 RT. Read More

    Severe hepatocytotoxicity linked to denosumab.
    Eur Rev Med Pharmacol Sci 2017 Mar;21(1 Suppl):78-85
    Department of Internal Medicine C, Kaplan Medical Center, Rehovot, Israel, Affiliated to The Hebrew University, Hadassah, Jerusalem, Israel.
    Objective: Denosumab (Prolia, Amgen, Thousand Oaks, CA, USA) is a fully human antibody to the receptor activator of nuclear factor-KB ligand (RANKL). We present a case of submassive hepatic necrosis with evidence implicating cytokine induction resulting from an immune reaction to denosumab.

    Case Report: A 72-year-old lady presented with elevated liver enzymes. Read More

    Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection.
    J Zhejiang Univ Sci B 2017 Apr.;18(4):277-288
    State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
    Herpes simplex virus type 1 (HSV-1), a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Read More

    Evidence for a Mesothelial Origin of Body Cavity Effusion Lymphomas.
    J Natl Cancer Inst 2017 Sep;109(9)
    Affiliations of authors: Laboratory of Cellular Oncology (DS-M, HQ, HO, GT), HIV and AIDS Malignancy Branch (TSU, MNP, KMW, KA, VW, RY), Women's Malignancies Branch (CMA), Laboratory of Pathology (MR), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD; Viral Oncology Section, AIDS and Cancer Virus Program, Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD (VAM, DW).
    Background: Primary effusion lymphoma (PEL) is a Kaposi's sarcoma herpes virus (KSHV)-induced lymphoma that typically arises in body cavities of HIV-infected patients. PEL cells are often co-infected with Epstein-Barr virus (EBV). "PEL-like" lymphoma is a KSHV-unrelated lymphoma that arises in body cavities of HIV-negative patients. Read More

    Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia.
    Leuk Lymphoma 2017 Apr 3:1-12. Epub 2017 Apr 3.
    a Department of Pediatrics , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
    The human herpes virus, Epstein-Barr virus (EBV), is a known oncogenic virus and plays important roles in life-threatening T/NK-cell lymphoproliferative disorders (T/NK-cell LPD) such as hypersensitivity to mosquito bite (HMB), chronic active EBV infection (CAEBV), and NK/T-cell lymphoma/leukemia. During the clinical courses of HMB and CAEBV, patients frequently develop malignant lymphomas and the diseases passively progress sequentially. In the present study, gene expression of CD16((-))CD56((+))-, EBV((+)) HMB, CAEBV, NK-lymphoma, and NK-leukemia cell lines, which were established from patients, was analyzed using oligonucleotide microarrays and compared to that of CD56(bright)CD16(dim/-) NK cells from healthy donors. Read More

    The impact of an immunization check-up at a pharmacist-provided employee health screening.
    J Am Pharm Assoc (2003) 2017 Mar 31. Epub 2017 Mar 31.
    Objectives: To determine which types of vaccine recommendations were accepted and acted upon by patients after an immunization check-up at a pharmacist-provided employee health screening, and to evaluate if there was a difference between influenza and non-influenza vaccines.

    Design: Retrospective, observational.

    Setting: Supermarket chain. Read More

    Valacyclovir as Initial Treatment for Acute Retinal Necrosis: A Pharmacokinetic Modeling and Simulation Study.
    Curr Eye Res 2017 Mar 30:1-4. Epub 2017 Mar 30.
    a Center for Translational Medicine, School of Pharmacy , University of Maryland , Baltimore , Maryland , USA.
    Purpose: Acute retinal necrosis (ARN) is a feared complication of infectious retinitis most commonly caused by varicella zoster virus (VZV). We performed a pharmacokinetic modeling and simulation study by integrating the existing understanding of physiology with previously published data to evaluate the vitreal penetration of oral valacyclovir for the treatment of ARN, under various dosing scenarios.

    Method: We compared different oral valacyclovir dosing regimens with intravenous acyclovir. Read More

    Sexually transmitted infections: old foes on the rise.
    Microb Cell 2016 Sep 5;3(9):361-362. Epub 2016 Sep 5.
    Institute of Molecular Biosciences, NAWI Graz, University of Graz, Humboldtstr. 50, 8010 Graz, Austria. ; BioTechMed-Graz, Humboldtstr. 50, 8010 Graz, Austria.
    Sexually transmitted infections (STIs) are commonly spread via sexual contact. It is estimated that one million STIs are acquired every day worldwide. Besides their impact on sexual, reproductive and neonatal health, they can cause disastrous and life-threatening complications if left untreated. Read More

    Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells.
    J Virol 2017 Mar 29. Epub 2017 Mar 29.
    Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
    Upon herpes simplex virus 1 (HSV-1) infection, the CD98 heavy chain (CD98hc) is redistributed around the nuclear membrane (NM), where it promotes viral de-envelopment during the nuclear egress of nucleocapsids. In this study, we attempted to identify the factor(s) involved in CD98hc accumulation and demonstrated the following: (i) the null mutation of HSV-1 UL34 caused specific dispersion throughout the cytoplasm of CD98hc and the HSV-1 de-envelopment regulators, glycoproteins B and H (gB and gH); (ii) as observed with CD98hc, gB, and gH, wild-type HSV-1 infection caused redistribution of the endoplasmic reticulum (ER) markers calnexin and ERp57 around the NM; whereas the UL34-null mutation caused cytoplasmic dispersion of these markers; (iii) the ER markers colocalized efficiently with CD98hc, gB, and gH in the presence and absence of UL34 in HSV-1-infected cells; (iv) at the ultrastructural level, wild-type HSV-1 infection caused ER compression around the NM, whereas the UL34 null mutation caused cytoplasmic dispersion of the ER; and (v) the UL34 null mutation significantly decreased the colocalization efficiency of lamin protein markers of the NM with CD98hc and gB. Collectively, these results indicate that HSV-1 infection causes redistribution of the ER around the NM, with resulting accumulation of ER-associated CD98hc, gB, and gH around the NM; and that UL34 is required for ER redistribution as well as for efficient recruitment to the NM of the ER-associated de-envelopment factors. Read More

    Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children.
    PLoS One 2017 28;12(3):e0174089. Epub 2017 Mar 28.
    Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
    Background: The dissociation between specific IgE and skin prick test reactivity to aeroallergens, a common finding in populations living in low and middle-income countries, has important implications for the diagnosis and treatment of allergic diseases. Few studies have investigated the determinants of this dissociation. In the present study, we explored potential factors explaining this dissociation in children living in an urban area of Northeast Brazil, focusing in particular on factors associated with poor hygiene. Read More

    Herpes simplex virus-1 and cytomegalovirus DNAs detection in the inner ear of implanted patients with non-congenital infection.
    Acta Otolaryngol 2017 Mar 23:1-6. Epub 2017 Mar 23.
    a Department of Head and Neck Surgery, Institute of Otorhinolaryngology , Catholic University of Sacred Heart , Rome , Italy.
    Conclusions: The detection of cytomegalovirus (CMV) and herpes simplex virus-1 (HSV-1) genome in perilymph of patients with negative serology or clinical history for congenital infections supports the hypothesis that Herpesviridae, even after acquired postnatal infections, could remain in latent phase in the spiral ganglion and damage the cochlea by a possible subsequent reactivation. Further studies are needed to identify the markers of such reactivation.

    Objective: To identify the presence of certain viral species in the endolabyrinthic fluid of deaf patients with non-congenital infection. Read More

    Asthma Status is an Independent Risk Factor for Herpes Zoster in Children: A Population-Based Cohort Study.
    Ann Med 2017 Mar 23:1-24. Epub 2017 Mar 23.
    e College of Medicine, China Medical University , Taichung , Taiwan.
    The literature regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. From the National Health Insurance Research Database, a total of 600,891 children were enrolled in this study between 2000 and 2007. Read More

    Peptides Derived from Glycoproteins H and B of Herpes Simplex Virus Type 1 and Herpes Simplex Virus Type 2 Are Capable of Blocking Herpetic Infection in vitro.
    Intervirology 2017 Mar 23;59(5-6):235-242. Epub 2017 Mar 23.
    Laboratorio de Virología, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico City, Mexico.
    Aims: The aim of this study was to design peptides derived from glycoproteins H (gH) and B (gB) of herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) with the potential to block herpetic infection and to evaluate their ability to inhibit HSV-1 and HSV-2 infection in vitro.

    Methods: A library of continuous 15-25 residue stretches (CRSs) located at the surface of gH and gB from HSV-1 and HSV-2 was created. These CRSs were analyzed, and only those that were highly flexible and rich in charged residues were selected for the design of the antiviral peptides (AVPs). Read More

    HSV-1 interaction to 3-O-sulfated heparan sulfate in mouse-derived DRG explant and profiles of inflammatory markers during virus infection.
    J Neurovirol 2017 Mar 21. Epub 2017 Mar 21.
    Department of Anatomy, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, 60515, USA.
    The molecular mechanism of herpes simplex virus (HSV) entry and the associated inflammatory response in the nervous system remain poorly understood. Using mouse-derived ex vivo dorsal root ganglia (DRG) explant model and single cell neurons (SCNs), in this study, we provided a visual evidence for the expression of heparan sulfate (HS) and 3-O-sulfated heparan sulfate (3-OS HS) followed by their interactions with HSV-1 glycoprotein B (gB) and glycoprotein D (gD) during cell entry. Upon heparanase treatment of DRG-derived SCN, a significant inhibition of HSV-1 entry was observed suggesting the involvement of HS role during viral entry. Read More

    Comparison of different methods for extraction of Cinnamomi ramulus: yield, chemical composition and in vitro antiviral activities.
    Nat Prod Res 2017 Mar 21:1-5. Epub 2017 Mar 21.
    a Experiment Center for Teaching and Learning , Shanghai University of Traditional Chinese Medicine , Shanghai , China.
    Hydrodistillation (HD), supercritical fluid extraction (SFE) and reflux extraction (RE) were applied to obtain Cinnamomi ramulus extracts. The yields, chemical compositions and antiviral activities of the extracts were investigated. Extracts were analysed using gas chromatography-mass spectrometry and the antiviral activities were evaluated using cytopathic effect inhibition assay. Read More

    Mediastinal syndrome from plasmablastic lymphoma in human immunodeficiency virus and human herpes virus 8 negative patient with polycythemia vera: a case report.
    J Med Case Rep 2017 Mar 21;11(1):75. Epub 2017 Mar 21.
    Department of Surgical, Oncological and Stomatological Disciplines, University of Palermo, Via Del Vespro 129, 90127, Palermo, Italy.
    Background: Plasmoblastic lymphoma is a rare and aggressive subtype of diffuse large B cell lymphoma, which occurs usually in the jaw of immunocompromised subjects.

    Case Presentation: We describe the occurrence of plasmoblastic lymphoma in the mediastinum and chest wall skin of an human immunodeficiency virus-negative 63-year-old Caucasian man who had had polycytemia vera 7 years before. At admission, the patient showed a superior vena cava syndrome, with persistent dyspnoea, cough, and distension of the jugular veins. Read More

    Safety of synthetic and biological DMARDs: a systematic literature review informing the 2016 update of the EULAR recommendations for management of rheumatoid arthritis.
    Ann Rheum Dis 2017 Mar 15. Epub 2017 Mar 15.
    Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology Center, Amsterdam, The Netherlands.
    Objectives: To assess the safety of synthetic (s) and biological (b) disease-modifying antirheumatic drugs (DMARDs) for the management of rheumatoid arthritis (RA) to inform the European League Against Rheumatism recommendations for the management of RA.

    Methods: Systematic literature review (SLR) of observational studies comparing any DMARD with another intervention for the management of patients with RA. All safety outcomes were included. Read More

    Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).
    Med Chem 2017 03 7. Epub 2017 Mar 7.
    Department of Applied Chemistry and Pharmaceutics, Beijing Institute of Technology, Beijing 100081. China.
    Background: All of clinic drugs for herpesvirus infections exhibit high toxicity and suffer from significant drug-resistantance. There is a great need for the development of new, effective, and safe anti-herpesvirus agents with different mechanisms of action.

    Methods: A series of novel 5-(benzylthio)-1H-1,2,3- triazole-4-carboxamides were efficiently synthesized and EC50 values against human cytomegalovirus (HCMV), varicella-zoster virus (VZV) and herpes simplex virus (HSV) were evaluated in vitro. Read More

    Antiviral activity of cationic amphiphilic drugs.
    Expert Rev Anti Infect Ther 2017 May 20;15(5):483-492. Epub 2017 Mar 20.
    a Department of Molecular Medicine , University of Padova , Padova , Italy.
    Introduction: Emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. Areas covered: A recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. A number of FDA-approved drugs used to treat several human diseases are cationic amphiphilic drugs (CADs) that have the ability to accumulate inside cells affecting several structures/functions hijacked by viruses during infection. Read More

    Quantitative analysis of rutin, quercetin, naringenin, and gallic acid by validated RP- and NP-HPTLC methods for quality control of anti-HBV active extract of Guiera senegalensis.
    Pharm Biol 2017 Dec;55(1):1317-1323
    a Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
    Context: Guiera senegalensis J.F. Gmel (Combretaceae) is a folk medicinal plant used in various metabolic and infectious diseases. Read More

    Decreased HHV-6 IgG in Alzheimer's Disease.
    Front Neurol 2017 20;8:40. Epub 2017 Feb 20.
    Department of Medical Sciences, Uppsala University , Uppsala , Sweden.
    Human herpesviruses have previously been implicated in the pathogenesis of Alzheimer's disease (AD) but whether they are causal, facilitating, or confounding factors is yet to be established. A total of 50 AD subjects and 52 non-demented (ND) controls were analyzed in a multiplex assay for IgG reactivity toward herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and human herpesvirus 6 (HHV-6). The HHV-6 IgG reactivity was significantly lower in AD subjects compared to ND controls, whereas there were no differences in HSV, VZV, or CMV antibody levels between the groups. Read More

    Peritonsillar abscess: clinical aspects of microbiology, risk factors, and the association with parapharyngeal abscess.
    Dan Med J 2017 Mar;64(3)
    PTA is a collection of pus located between the tonsillar capsule and the pharyngeal constrictor muscle. It is considered a complication of acute tonsillitis and is the most prevalent deep neck infection (approximately 2000 cases annually in Denmark) and cause of acute admission to Danish ENT departments. Teenagers and young adults are most commonly affected and males may predominate over females. Read More

    Infections in severe alcoholic hepatitis.
    Ann Gastroenterol 2017 27;30(2):152-160. Epub 2016 Oct 27.
    Department of Gastroenterology and Hepato-Pancreatology, C.U.B. Erasme, Université Libre de Bruxelles (Christophe Moreno, Thierry Gustot); Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles (Christophe Moreno, Thierry Gustot), Brussels, Belgium; Inserm Unité 1149, Centre de Recherche sur l'Inflammation (CRI), Paris, France (Thierry Gustot).
    Severe alcoholic hepatitis (sAH), defined by a modified discriminant function ≥32, is the most severe form of alcohol-induced liver disease and is associated with a 1-month mortality rate of around 30%. Corticosteroid treatment remains the only therapeutic option that improves short-term survival. Infectious complications, occurring in approximately 50% of patients, are the main causes of death, even in patients who benefit from corticosteroids. Read More

    Human herpes virus-6 encephalitis causing severe anterograde amnesia associated with rituximab, azathioprine and prednisolone combination therapy for dermatomyositis.
    J Neurovirol 2017 Feb 21. Epub 2017 Feb 21.
    Department of Neurosciences, North Bristol NHS Trust, Southmead Hospital, Bristol, UK.
    Human herpes virus-6 (HHV-6) reactivation is a well-recognised complication following haematological stem cell transplantation, but it is novel in the context of combination immunomodulatory therapy for autoimmune disease. We report a case of severe anterograde amnesia caused by HHV-6 encephalitis in a young female patient on rituximab, azathioprine and prednisolone for dermatomyositis (DM). The use of targeted biologic treatments for systemic autoimmune connective tissue diseases (CTDs) is increasing, particularly when refractory to conventional management. Read More

    Dendritic cells, macrophages, NK and CD8(+) T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B.
    Virol J 2017 Feb 21;14(1):37. Epub 2017 Feb 21.
    Imunologia de Doenças Virais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Fiocruz, Avenida Augusto de Lima 1715, Belo Horizonte, 30190-002, MG, Brazil.
    Background: Herpes simplex virus type 1 (HSV-1) cause not only mild symptoms but also blindness and encephalitis. It was previously shown that the immune response against HSV-1 occurs mainly in the trigeminal ganglia (TG) and that Toll-like receptors 2 and 9 (TLR2/9) are important in mediating this response. It was also demonstrated that iNOS (nitric oxide synthase) and interleukin 1 beta (IL-1β) play an essential role in the defense against HSV-1 infection. Read More

    The role of age-sex interaction in the development of post-herpetic neuralgia.
    Hum Vaccin Immunother 2017 Feb;13(2):376-378
    a Department of Health Sciences , University of Genoa , Genoa , Italy.
    Post-herpetic neuralgia is the most frequent complication of herpes zoster and affects up to 30% of patients. Increased age is a well-recognized risk factor, while the role of gender is highly uncertain. Little research has been performed into a possible combined effect of age and sex in post-herpetic neuralgia. Read More

    Seroprevalence of Common Viral Diseases: A Hospital Based Study from Amritsar, India.
    J Clin Diagn Res 2016 Dec 1;10(12):DC15-DC19. Epub 2016 Dec 1.
    Research Assistant, Department of Viral Research and Diagnostic Laboratory, Government Medical College , Amritsar, Punjab, India .
    Introduction: There is a paucity of published data on epidemiology of the viral infections in Punjab, India. The Viral Research and Diagnostic Laboratory (VRDL) located at Government Medical College (GMC), Amritsar conducts the initial diagnosis of common viruses circulating in the region.

    Aim: To report the seroprevalence of various viral diseases in Amritsar and neighboring districts of Punjab along with the demographic and geographical data of the patients. Read More

    HIV and STI s among men who have sex with men in Dodoma municipality, Tanzania: a cross-sectional study.
    Sex Transm Infect 2017 Feb 15. Epub 2017 Feb 15.
    Department of Behavioural Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
    Objectives: To determine the seroprevalence of HIV, STI and related risks among men who have sex with men (MSM) in Dodoma municipality, Tanzania.

    Methods: A cross-sectional study using respondent-driven sampling was employed to recruit study participants aged 18 years and above. Data on sociodemographics, HIV/STI knowledge and sexual practices were collected. Read More

    Investigations in GABAA receptor antibody-associated encephalitis.
    Neurology 2017 Mar 15;88(11):1012-1020. Epub 2017 Feb 15.
    From the Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) (M.S., M.P.-P., T.A., M.R.R., F.G., J.D.), University of Barcelona, Spain; University of Lausanne (UNIL) (M.S.), Switzerland; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) (M.P.-P., T.A., M.R.R., J.D., F.G.), Madrid, Spain; Neurology Service (T.A., J.D.), Hospital Sant Joan de Déu, Barcelona, Spain; Neurology Division, Hospital das Clínicas (M.M.S.), São Paulo University, Brazil; Hospital de Base (F.J.C.), Brasília, Brazil; Service of Neurology (M.I.B.A.) and Service of Immunology (M.R.J.B.), University Hospital of Son Espases, Mallorca, Spain; Department of Neurology (L.B., M.G.), Children's Hospital, Boston, MA; Pediatric Neurology Section (A.F.), Vall d'Hebron University Hospital, Barcelona, Spain; Hospital Nacional Edgardo Rebagliati Martins (R.L.C.O.), Lima, Peru; Department of Neurology (M.R.R., J.D.), University of Pennsylvania, Philadelphia; Service of Neurology (F.G., J.D.), Hospital Clínic; and Catalan Institution for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
    Objective: To report the clinical features, comorbidities, receptor subunit targets, and outcome in patients with anti-GABAA receptor (GABAAR) encephalitis.

    Methods: Clinical study of 26 patients, including 17 new (April 2013-January 2016) and 9 previously reported patients. Antibodies to α1, β3, and γ2 subunits of the GABAAR were determined using reported techniques. Read More

    Ethnic variation in medical and lifestyle risk factors for B cell non-Hodgkin lymphoma: A case-control study among Israelis and Palestinians.
    PLoS One 2017 14;12(2):e0171709. Epub 2017 Feb 14.
    School of Public Health, Hadassah-Hebrew University Medical Organization, Jerusalem, Israel.
    Background: Risk factors for B-cell non-Hodgkin lymphoma (B-NHL) have not been assessed among Palestinian Arabs (PA) and Israeli Jews (IJ).

    Methods: In a case-control study we investigated self-reported medical and lifestyle exposures, reporting odds ratios (ORs) and 95% confidence intervals [CIs], by ethnicity, for overall B-NHL and subtypes.

    Results: We recruited 823 cases and 808 healthy controls. Read More

    Infectivity inhibition by overlapping synthetic peptides derived from the gH/gL heterodimer of herpes simplex virus type 1.
    J Pept Sci 2017 Apr 14;23(4):311-319. Epub 2017 Feb 14.
    Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Via De Crecchio 7, 80138, Naples, Italy.
    Herpes simplex virus (HSV) is a human pathogen that infects epithelial cells. The cutaneous lesions, caused by the virus, spread to the nervous system creating several complications. Fusion of host membranes with the viral envelope is mandatory and mediated by a group of glycoproteins conserved in all Herpesviridae subfamilies, such as the glycoproteins B (gB), H (gH), L (gL) and D (gD). Read More

    Participation of 3-O-sulfated heparan sulfates in the protection of macrophages by herpes simplex virus-1 glycoprotein D and cyclophilin B against apoptosis.
    FEBS Open Bio 2017 Feb 24;7(2):133-148. Epub 2016 Dec 24.
    Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) UMR 8576 CNRS University of Lille France.
    Heparan sulfates (HS) are involved in numerous biological processes, which rely on their ability to interact with a large panel of proteins. Although the reaction of 3-O-sulfation can be catalysed by the largest family of HS sulfotransferases, very few mechanisms have been associated with this modification and to date, only glycoprotein D (gD) of herpes simplex virus-1 (HSV-1 gD) and cyclophilin B (CyPB) have been well-described as ligands for 3-O-sulfated HS. Here, we hypothesized that both ligands could induce the same responses via a mechanism dependent on 3-O-sulfated HS. Read More

    Alliacane sesquiterpenoids from submerged cultures of the basidiomycete Inonotus sp. BCC 22670.
    Phytochemistry 2017 Apr 5;136:175-181. Epub 2017 Feb 5.
    National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
    Nine alliacane sesquiterpenoids, inonoalliacanes A-I, were isolated from culture broth of the basidiomycete Inonotus sp. BCC 22670. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Read More

    Seek and destroy: targeted adeno-associated viruses for gene delivery to hepatocellular carcinoma.
    Drug Deliv 2017 Nov;24(1):289-299
    a Gallipoli Medical Research Institute, Greenslopes Private Hospital , Brisbane , QLD , Australia.
    Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer with high incidence globally. Increasing mortality and morbidity rates combined with limited treatment options available for advanced HCC press for novel and effective treatment modalities. Gene therapy represents one of the most promising therapeutic options. Read More

    Herpesvirus DNA polymerases: Structures, functions and inhibitors.
    Virus Res 2017 Jan 30. Epub 2017 Jan 30.
    Research Center in Infectious Diseases, CHU de Québec and Laval University, Quebec City, Quebec, Canada. Electronic address:
    Human herpesviruses are large double-stranded DNA viruses belonging to the Herpesviridae family. These viruses have the ability to establish lifelong latency into the host and to periodically reactivate. Primary infections and reactivations of herpesviruses cause a large spectrum of diseases and may lead to severe complications in immunocompromised patients. Read More

    Age-related EBV positive clonal B-cell Lymphoid proliferation (EBV+-DLBCL).
    J Clin Exp Dent 2017 Jan 1;9(1):e163-e166. Epub 2017 Jan 1.
    Associate Prof Oral Medicine, MD, DDS, PhD, Medical School of Athens, NKUA.
    The Ebstein Barr virus(EBV), herpes virus 5 has been associated with lymphoproliferative disordrers. Age-related EBV+ B-LPD is defined as an EBV+ clonal B-cell lymphoid proliferation or EBV+-DLBCL developing in patients over the age of 40 years in the absence of any known immunodeficiency and without an underlying T-cell lymphoma1. We present a case of EBV+ clonal B-cell lymphoid proliferation. Read More

    [Herpes zoster in elderly adults in a community hospital in Buenos Aires. June 2013-May 2014].
    Medicina (B Aires) 2017 ;77(1):24-30
    Sección Geriatría, Servicio de Clínica Médica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
    Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus. Its main risk factor is increasing age and comorbidities. There are limited data on the characteristics of HZ in South America, especially in the elderly. Read More

    Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.
    Acta Dermatovenerol Croat 2016 Dec;24(4):312-313
    Efstathia Pasmatzi, MD, Department of Dermatology, School of Medicine, University of Patras, 26504 Rio-Patras, Greece;
    Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks. Read More

    Vesicular Contact Reaction May Progress into Erythema Multiforme.
    Acta Dermatovenerol Croat 2016 Dec;24(4):307-309
    Prof. Magdalena Czarnecka-Operacz, MD, PhD, Department of Dermatology, 49 Przybyszewski Str., 60-355 Poznań, Poland.
    Dear Editor, Erythema multiforme is considered an acute skin condition, characterized by a self-limiting and sometimes recurrent course. It is regarded as a type IV hypersensitivity reaction associated with certain infections, medications, and other various triggers. Allergic contact dermatitis is in turn a delayed type of induced allergy as a result of cutaneous contact with a specific allergen to which the patient develops specific sensitivity. Read More

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