Search our Database of Scientific Publications and Authors

I’m looking for a

    6292 results match your criteria Herpes B

    1 OF 126

    Persistence of immune response to an adjuvanted varicella-zoster virus subunit vaccine for up to year nine in older adults.
    Hum Vaccin Immunother 2018 Feb 20. Epub 2018 Feb 20.
    b GSK , Wavre , Belgium.
    Background: In adults aged ≥60 years, two doses of the herpes zoster subunit vaccine (HZ/su; 50µg varicella-zoster virus glycoprotein E [gE] and AS01Adjuvant System) elicited humoral and cell-mediated immune responses persisting for at least six years. We assessed immunogenicity nine years post-initial vaccination.

    Methods: This open extension study (NCT02735915) followed 70 participants who received two HZ/su doses in the initial trial (NCT00434577). Read More

    Sexually transmitted infections and immune activation among HIV-infected but virally suppressed youth on antiretroviral therapy.
    J Clin Virol 2018 Feb 7;102:7-11. Epub 2018 Feb 7.
    Duke University, School of Medicine, Department of Pediatrics, 133 MSRB I, DUMC Box 2644, Durham, NC, 27710, United States.
    Background: Human immunodeficiency virus (HIV) infection is associated with chronic immune activation, and concurrent sexually transmitted infections (STIs) may increase immune activation.

    Objectives: Because HIV-infected youth are at high risk of STIs and little is known about the impact of STIs on immune activation in HIV-infected youth, we conducted an exploratory study examining the association between STIs and systemic inflammation and immune activation among HIV-infected adolescents.

    Study Design: Forty-nine behaviorally infected U. Read More

    American tegumentary leishmaniasis: diagnostic and treatment challenges in a clinical case.
    Rev Inst Med Trop Sao Paulo 2018 15;60:e3. Epub 2018 Feb 15.
    Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Maringá, Paraná, Brazil.
    This clinical case presents a patient with a raised and ulcerative lesion with erythematous edges in the mouth, on the lower lip that was unsuccessfully treated as herpes labialis. Clinical data and laboratory tests (Montenegro skin test, indirect immunofluorescence, direct parasite search and polymerase chain reaction) led to the diagnosis of American tegumentary leishmaniasis caused by Leishmania (Viannia) sp. Treatment with pentavalent antimonial (Glucantime®) for 120 days was not effective and administration of amphotericin B for 30 days resulted in wound healing. Read More

    In vitro anti-influenza virus effect of total flavonoid from Trollius ledebouri Reichb.
    J Int Med Res 2018 Jan 1:300060517750284. Epub 2018 Jan 1.
    4 Department of Genomics Research, R&D Solutions, Elsevier Inc., Rockville, MD, USA.
    Objective To investigate the in vitro antivirus effect of total flavonoid from Trollius ledebouri Reichb (TFTLR). Methods Madin-Darby canine kidney (MDCK) and Human epithelial type 2 (HEp-2) cell lines were used to test the antivirus effect of TFTLR on nine virus subtypes: four H1N1, one H3N2, and four other subtypes prevalent in North China. Tamiflu, Ribavirin and Lianhua Qingwen were used as active comparators. Read More

    Laser Adjuvant-Assisted Peptide Vaccine Promotes Skin Mobilization of Dendritic Cells and Enhances Protective CD8Tand TCell Responses Against Herpes Infection and Disease.
    J Virol 2018 Feb 7. Epub 2018 Feb 7.
    Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA 92697
    There is an urgent need for chemical-free and biological-free safe adjuvants to enhance the immunogenicity of vaccines against the widespread viral pathogens, such as herpes simplex viruses type 2 (HSV-2), that infect a large proportion of the world human population. In the present study, we investigated the safety, immunogenicity and protective efficacy of a laser adjuvant peptide vaccine (LAP vaccine) in the B6 mouse model of genital herpes. This LAP vaccine, and its laser-free peptide vaccine analog (LFP vaccine), contain the immunodominant HSV-2 glycoprotein B CD8T cell epitope (HSV-gB) covalently linked with the promiscuous glycoprotein D CD4T helper cell epitope (HSV-gD). Read More

    Design of miRNA sponges for MDV-1 as a therapeutic strategy against lymphomas.
    Oncotarget 2018 Jan 17;9(3):3842-3852. Epub 2017 Dec 17.
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China.
    Lymphomas are solid-type tumors containing lymphoid cells. Some of latent herpesvirus infections established in B and/or T-lymphocytes could result in the formation of lymphomas. Marek's disease virus serotype 1 (MDV-1) is an avian herpes virus causing to lymphoproliferative tumors in birds, known as Marek's disease (MD). Read More

    Talimogene Laherparepvec: First in Class Oncolytic Virotherapy.
    Hum Vaccin Immunother 2018 Feb 8. Epub 2018 Feb 8.
    b School of Medicine, University of Alabama at Birmingham ,2145 Bonner Way, Bimingham , AL , United States , 35243.
    Oncolytic viruses represent a novel drug class in which native or modified viruses mediate tumor regression through selective replication within and lysis of tumor cells as well as induction of systemic antitumor immunity capable of eradicating tumor at distant, uninjected sites. Talimogene laherparepvec (TVEC) is a type I herpes simplex virus genetically modified to preferentially replicate in tumor cells, enhance antigen loading of MHC class I molecules and express granulocyte-macrophage colony-stimulating factor to increase tumor-antigen presentation by dendritic cells. It is presently the only oncolytic virus approved by the FDA with an indication for advanced melanoma based upon improved durable response rate in a randomized, phase III trial. Read More

    Guillain-Barré syndrome following varicella-zoster virus infection.
    Eur J Clin Microbiol Infect Dis 2018 Mar 6;37(3):511-518. Epub 2018 Feb 6.
    Departments of Neurology and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    We describe the frequency, clinical features, and electrophysiological and immunological phenotypes of Guillain-Barré Syndrome (GBS) patients treated at a single institution in Bangladesh who had preceding chicken pox (primary Varicella-zoster virus [VZV] infection) within 4 weeks of GBS onset. A literature review of GBS cases preceding VZV infection is also provided. Diagnosis of GBS was based on the National Institute of Neurological Disorders and Stroke criteria for GBS. Read More

    Anti-infective potential of catechins and their derivatives against viral hepatitis.
    Clin Exp Vaccine Res 2018 Jan 29;7(1):37-42. Epub 2018 Jan 29.
    Department of Global Medical Science, Health & Wellness College, Sungshin University, Seoul, Korea.
    Polyphenols including catechins from green tea () have been reported to have anti-infective activities against a broad spectrum of viruses and other pathogens. During the last two decades, antiviral activities of catechins with different modes of action have been demonstrated on diverse families of viruses, such as human immunodeficiency virus, Herpes simplex virus, influenza virus, hepatitis B and C virus. In this study, we focused on the antiviral properties of catechins and their derivatives against viral hepatitis which have become a key public health issue due to their serious impact on human health with liver diseases. Read More

    The effects of rhEPO intervention for perinatal intrauterine herpes virus infection on preventing brain injury in preterm infants.
    Exp Ther Med 2018 Jan 31;15(1):271-275. Epub 2017 Oct 31.
    Department VI of Obstetrics, The Central Hospital of Tai'an, Tai'an, Shandong 271000, P.R. China.
    The ability of recombinant human erythropoietin (rhEPO) to protect preterm infants against perinatal intrauterine herpes virus infection-induced brain injury was studied. In total, 120 women infected with perinatal intrauterine herpes virus were randomized into four groups: A, B, C and D, and were given 1,500 IU (mother, pre-partum), 3,000 IU (mother, pre-partum), 250 IU/kg (infant, post-natal), and no rhEPO, respectively. Hemoglobin (Hb), reticulocyte (Ret), hematocrit (Hct), neuron specific enolase (NSE), myelin basic protein (MBP), and S100 protein B (S100B) levels were measured immediately (T) and at 1 week (T), 2 weeks (T), and 4 weeks (T) post-delivery. Read More

    Effectiveness of continuous epidural analgesia on acute herpes zoster and postherpetic neuralgia: A retrospective study.
    Medicine (Baltimore) 2018 Feb;97(5):e9837
    Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Seoul, Republic of Korea.
    Despite early treatment of herpes zoster (HZ), postherpetic neuralgia (PHN) can persist. This study was designed to compare the therapeutic and pain relief effects of continuous epidural analgesia (CEA) on the chronic phase as well as the acute phase of HZ with standard medical treatment.Medical records of 227 patients with moderate to severe zoster-associated pain that had not responded to standard medications were retrospectively reviewed. Read More

    Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation.
    J Infect Chemother 2018 Jan 16. Epub 2018 Jan 16.
    Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
    Disseminated fusariosis (DF) is a rare life threatening fungal infection in immunocompromised hosts. We herein report a case of a fatal DF mimicking varicella zoster virus (VZV) infection that was emerged from a localized genital infection during cord blood transplantation (CBT) in a patient with severe aplastic anemia (SAA). The patient developed an ulcer following small painful vesicles mimics herpes simplex virus infection (HSV) on the glans penis before CBT, but a Fusarium species was identified. Read More

    ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum.
    J Allergy Clin Immunol 2018 Jan 22. Epub 2018 Jan 22.
    Department of Pediatrics, National Jewish Health, Denver, CO; University of Colorado School of Medicine, Aurora, CO. Electronic address:
    Background: Atopic dermatitis (AD) is a common inflammatory skin disease. A subset of AD is susceptible to disseminated herpes simplex virus (HSV) infection, a complication termed as eczema herpeticum(ADEH+). The immune mechanisms causing ADEH+ remain elusive. Read More

    Lichen planus and lichenoid drug eruption after vaccination.
    Cutis 2017 Dec;100(6):E6-E20
    Harvard School of Public Health, Boston, Massachusetts, USA; and National Skin Centre, Singapore.
    Lichen planus (LP) and lichenoid drug eruptions (LDEs) uncommonly occur after vaccination, especially for hepatitis B and influenza. The key initiating event that leads to the development of postimmunization LP or LDE is not well understood. There have been prior reports of an association between several vaccines and LP. Read More

    Light-emitting diodes in dermatology: A systematic review of randomized controlled trials.
    Lasers Surg Med 2018 Jan 22. Epub 2018 Jan 22.
    Department of Dermatology, Downstate Medical Center, State University of New York, Brooklyn, New York.
    Objective: In dermatology, patient and physician adoption of light-emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic uses of LEDs in dermatology based on published efficacy and safety data.

    Methods: A systematic review of the published literature on the use of LED treatments for skin conditions was performed on September 13th 2017. Read More

    Prediction of conserved sites and domains in glycoproteins B, C and D of herpes viruses.
    Microb Pathog 2018 Jan 17;116:91-99. Epub 2018 Jan 17.
    Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, 54000, Pakistan. Electronic address:
    Glycoprotein B (gB), C (gC) and D (gD) of herpes simplex virus are implicated in virus adsorption and penetration. The gB, gC and gD are glycoproteins for different processes of virus binding and attachment to the host cells. Moreover, their expression is necessary and sufficient to induce cell fusion in the absence of other glycoproteins. Read More

    Role of B and T Lymphocyte Attenuator in Renal Transplant Recipients with Biopsy-Proven Acute Rejection.
    Med Sci Monit 2018 Jan 20;24:387-396. Epub 2018 Jan 20.
    Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China (mainland).
    BACKGROUND Acute rejection is a common predisposing cause of allograft dysfunction in kidney transplantation. Recently, the B and T lymphocyte attenuator (BTLA)/herpes virus entry mediator (HVEM)/lymphotoxin (LIGHT)/CD160 pathway was found to be potentially involved in the regulation of T cell activation. This could mean that this pathway is involved in graft rejection in kidney transplantation; the present study aimed to explore this possibility. Read More

    Semantic language deficit developing following herpes simplex encephalitis: reorganization "cannibalising" language centers?
    Neurocase 2018 Jan 19:1-4. Epub 2018 Jan 19.
    a Neuropsychiatry Unit , Royal Melbourne Hospital , Melbourne , Australia.
    Herpes simplex virus encephalitis (HSVE) commonly presents with severe amnesia due to virus-mediated destruction of key regions in the temporal lobes, although language and executive impairment has been described. Little is known however of the long-term cognitive changes in these patients, including changes that may happen with cortical reorganization. We describe a patient with HSVE who presented with a highly unusual late-onset language syndrome, which may reflect distal cortical changes after her original injury. Read More

    Macacine Herpesvirus 1 Antibody Prevalence and DNA Shedding among Invasive Rhesus Macaques, Silver Springs State Park, Florida, USA.
    Emerg Infect Dis 2018 Feb;24(2):345-351
    We compiled records on macacine herpesvirus 1 (McHV-1) seroprevalence and, during 2015-2016, collected saliva and fecal samples from the free-ranging rhesus macaques of Silver Springs State Park, a popular public park in central Florida, USA, to determine viral DNA shedding and perform sequencing. Phylogenetic analysis of the US5 and US5-US6 intragenic sequence from free-ranging and laboratory McHV-1 variants did not reveal genomic differences. In animals captured during 2000-2012, average annual seroprevalence was 25% ± 9 (mean ± SD). Read More

    Clinical Characteristics of Herpes Simplex Virus Associated Anterior Uveitis.
    Ocul Immunol Inflamm 2018 Jan 18:1-5. Epub 2018 Jan 18.
    d Department of Ophthalmology , University Medical Center , Utrecht , The Netherlands.
    Purpose: The aim of this study is to describe the clinical characteristics of molecularly proven Herpes simplex virus (HSV) anterior uveitis.

    Methods: The literature on HSV anterior uveitis whereby the diagnosis was confirmed by polymerase chain reaction (PCR) and or Goldmann-Witmer coefficient in aqueous humor was reviewed. Three studies from Europe and one from Japan could be included. Read More

    Screening of north-east Mexico medicinal plants with activities against herpes simplex virus and human cancer cell line.
    Nat Prod Res 2018 Jan 15:1-4. Epub 2018 Jan 15.
    b Facultad de Medicina, Departamento de Inmunología , Universidad Autónoma Nuevo León , San Nicolas de los Garza , México.
    The plants examined in this study have previous biological activity reports indicating the possibility of found activity against herpes and cancer cell. The aim of this contribution was to carry out a screening of Juglans mollis (Juglandaceae), Persea americana (Lauraceae), Hamelia patens (Rubiaceae), Salvia texana (Lamiaceae), Salvia ballotaeflora (Lamiaceae), Ceanothus coeruleus (Rhamnaceae), Chrysactinia mexicana (Asteraceae) y Clematis drummondii (Ranunculaceae), against HeLa cells, VHS-1 and VHS-2. The method MTT was used to determine the 50% cytotoxic concentration (CC), in Vero and HeLa cell lines. Read More

    [Dose-response relationship of ropivacaine for epidural block in early herpes zoster guided by CT].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3783-3786
    Department of Pain Management, the First Hospital of Jiaxing, Jiaxing 314000, China.
    To determine the dose-response relationship of ropivacaine for epidural block in early herpes zoster by CT guided.From January 2015 to February 2017, according to the principle of completely random digital table, 80 patients with early herpes zoster who were prepared for epidural block were divided into 4 groups(each group 20 patients): in group A the concentration of ropivacaine was 0.08%, in group B was 0. Read More

    Outcome of polymerase chain reaction (PCR) analysis in 100 suspected cases of infectious uveitis.
    J Ophthalmic Inflamm Infect 2018 Jan 10;8(1). Epub 2018 Jan 10.
    Uveitis and Ocular Pathology Department, Medical and Vision Research Foundations, Sankara Nethralaya, College road, Chennai, Tamil Nadu, India.
    Background: Polymerase chain reaction (PCR) analysis is an important tool in the diagnosis of infectious uveitis. A retrospective, interventional study of PCR analysis of ocular fluid in suspected infectious uveitis cases between January 2014 to July 2016 was done. Nested, real-time and broad range PCR was performed for detection of the genome of Mycobacterium tuberculosis, herpes virus family, Chikungunya virus, Toxoplasma gondii, fungus, eubacterium and propionibacterium acne. Read More

    European perspective on the management of rheumatoid arthritis: clinical utility of tofacitinib.
    Ther Clin Risk Manag 2018 21;14:15-29. Epub 2017 Dec 21.
    Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
    Xeljanz(tofacitinib) is an oral small-molecule inhibitor that reversibly inhibits Janus-activated kinase (JAK)-dependent cytokine signaling, thus reducing inflammation. As a result of these mechanisms, effects on the immune system such as a moderate decrease in the total lymphocyte count, a dose-dependent decrease in natural killer (NK) cell count, and an increase in B-cell count have been observed. Therefore, tofacitinib provides an innovative approach to modulating the immune and inflammatory responses in patients with rheumatoid arthritis (RA), which is especially important in individuals who do not respond to tumor necrosis factor inhibitors or show a loss of response over time. Read More

    The potential of currently unavailable herpes virus vaccines.
    Expert Rev Vaccines 2018 Mar 9;17(3):239-248. Epub 2018 Feb 9.
    b Galenbio Ltd , Mosonmagyaróvár , Hungary.
    Introduction: Despite overwhelming experimental work, there are no licensed vaccines against the most frequent Alphaherpesviruses, namely herpes simplex virus 1 and 2 (HSV1 and 2) nor against the Epstein-Barr virus (EBV), a member of the subfamily Gammaherpesvirus. Areas covered: Since the DNAs of both HSVs reside in the regional sensory ganglia in a latent state (i.e. Read More

    Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.
    Nat Microbiol 2018 Feb 1;3(2):172-180. Epub 2018 Jan 1.
    Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
    Epstein-Barr virus (EBV) is an oncogenic virus that infects more than 90% of the world's population. EBV predominantly infects human B cells and epithelial cells, which is initiated by fusion of the viral envelope with a host cellular membrane. The mechanism of EBV entry into B cells has been well characterized. Read More

    Association between virus exposure and depression in US adults.
    Psychiatry Res 2018 Mar 20;261:73-79. Epub 2017 Dec 20.
    Department of Psychology, Brigham Young University, Provo, UT, United States; The Neuroscience Center, Brigham Young University, Provo, UT, United States.
    Mood disorders are common mental illnesses. Among the factors associated with major depression are exposures to infectious diseases including hepatitis C, influenza, varicella-zoster, and herpes viruses. In this study, we sought to evaluate further associations between viral exposure and depression. Read More

    Risk assessment of colonization of legionella spp. in dental unit waterlines.
    Oral Implantol (Rome) 2017 Jul-Sep;10(3):283-288. Epub 2017 Nov 30.
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
    The aerosol produced during the use of dental instruments can spread pathogens potentially harmful to health. Most of the pathogens found in hydraulic system are Gram-negative aerobic heterotrophic environmental bacterial species exhibiting very low pathogenicity, although they may be of concern in the treatment of vulnerable patients, such as immunocompromised, medically compromised individuals and dental team. Dental team can be exposed to pathogenic microorganisms including cytomegalovirus, hepatitis B virus, hepatitis C virus, herpes simplex virus and Legionella spp. Read More

    Negative IgG Varicella Zoster Virus Antibody Status: Immune Responses Pre and Post Re-immunization.
    Infect Dis Ther 2017 Dec 22. Epub 2017 Dec 22.
    Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
    Introduction: Varicella zoster virus (VZV) causes chicken pox and herpes zoster and is a self-limiting disease in healthy children. Vaccination is recommended for children, adolescents, and adults. This study discusses a healthy pediatric patient with negative immunoglobulin (Ig) G VZV antibody (Ab) status after two doses of varicella vaccine and then subsequently re-immunized. Read More

    Pathogenesis of Non-Zika Congenital Viral Infections.
    J Infect Dis 2017 Dec;216(suppl_10):S912-S918
    Division of Pediatric Infectious Diseases, University of Alabama at Birmingham.
    A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 from South and Central America and the Caribbean. Although the full spectrum of ZIKV infection of the newborn has yet to be determined, other maternal viral infections resulting in transmission to the fetus provide instructive lessons that can be applied to the prospective evaluation of individuals with ZIKV infection. This review focuses on those other congenital infections, including rubella, congenital cytomegalovirus, human immunodeficiency virus, hepatitis B virus, and neonatal herpes simplex virus, from which lessons for the evaluation of ZIKV in the newborn can be applied. Read More

    Serological Evidence of Borrelia Burgdorferi Infection in Mexican Patients with Facial Palsy.
    Rev Invest Clin 2017 Nov-Dec;69(6):344-348
    Unidad de Investigación Médica de Enfermedades Infecciosas y Parasitarias (UIMEIP), Hospital de Pediatría, Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
    Background: Facial palsy is the most frequent manifestation of neuroborreliosis in the United States, Europe, and Asia, whereas in Mexico, its frequency is unknown.

    Objective: We aimed to determine the frequency of Borrelia spp. infection in patients with acute facial palsy in Mexico. Read More

    Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity.
    NPJ Vaccines 2017 8;2:25. Epub 2017 Sep 8.
    GSK Vaccines, Rixensart, Belgium.
    Combining immunostimulants in adjuvants can improve the quality of the immune response to vaccines. Here, we report a unique mechanism of molecular and cellular synergy between a TLR4 ligand, 3--desacyl-4'-monophosphoryl lipid A (MPL), and a saponin, QS-21, the constituents of the Adjuvant System AS01. AS01 is part of the malaria and herpes zoster vaccine candidates that have demonstrated efficacy in phase III studies. Read More

    Letter to the editor regarding "The role of age-sex interaction in the development of post-herpetic neuralgia".
    Hum Vaccin Immunother 2017 Dec 15:1-3. Epub 2017 Dec 15.
    b Universidad Católica de Valencia San Vicente Mártir , Valencia , Spain.
    The objective of the study was to evaluate the role of age and sex and their combined effect in the development of post-herpetic neuralgia (PHN) in a large population-based study, in order to confirm the results published previously by Amicizia et al. Data were extracted from population and healthcare databases from the Valencia Region (2009-2014). Logistic regressions were implemented to estimate the effect of increasing age on the probability of developing PHN stratified by sex. Read More

    Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China.
    Acta Derm Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
    DRESS is one of the most severe drug reactions. The aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of DRESS. A total of 52 patients with DRESS, who were inpatients at a medical referral centre in Shanghai, China, from January 2011 to December 2016, were analysed retrospectively. Read More

    Fetal Anemia Causing Hydrops Fetalis From an Alpha-Globin Variant: Homozygous Hemoglobin Constant Spring.
    J Pediatr Hematol Oncol 2017 Dec 12. Epub 2017 Dec 12.
    Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Muang, Khon Kaen, Thailand.
    Background: Fetal anemia is often assumed to be due to red cell alloimmunization and Parvovirus infection, and can lead to hydrops fetalis and death in utero. Other causes, such as mutations of hemoglobin alpha, are less commonly considered.

    Methods: We report 7 cases with fetal anemia causing hydrops fetalis. Read More

    Herpes Simplex Virus 1 DNA Polymerase RNase H Activity Acts in a 3'-to-5' Direction and Is Dependent on the 3'-to-5' Exonuclease Active Site.
    J Virol 2018 Mar 12;92(5). Epub 2018 Feb 12.
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    The catalytic subunit (Pol) of herpes simplex virus 1 (HSV-1) DNA polymerase has been extensively studied both as a model for other family B DNA polymerases and for its differences from these enzymes as an antiviral target. Among the activities of HSV-1 Pol is an intrinsic RNase H activity that cleaves RNA from RNA-DNA hybrids. There has long been a controversy regarding whether this activity is due to the 3'-to-5' exonuclease of Pol or whether it is a separate activity, possibly acting on 5' RNA termini. Read More

    Relationship between patient copayments in Medicare Part D and vaccination claim status for herpes zoster and tetanus-diphtheria-acellular pertussis.
    Curr Med Res Opin 2018 Jan 10:1-9. Epub 2018 Jan 10.
    a GSK, US Health Outcomes & Epidemiology - Vaccines , Philadelphia , PA , USA.
    Objective: To assess the relationship between copay amount and vaccination claim submission status for tetanus-diphtheria-acellular pertussis (Tdap) and herpes zoster (GSK study identifier: HO-14-14319).

    Methods: Retrospective analyses were performed using vaccination administrative claims data in patients aged ≥65 years with ≥1 claim for Tdap or zoster vaccines between 2012 and 2014. To avoid confounding by other financial responsibility, analyses were conducted among patients in the copayment phase of insurance. Read More

    [Kaposi's sarcoma of the penis in a HIV-seronegative patient].
    Pan Afr Med J 2017 21;28:61. Epub 2017 Sep 21.
    Université Mohammed 5, Faculté de Médecine et de Pharmacie de Rabat, Hopital Ibn Sina, Service d'Urologie B, Maroc.
    Sarcomas of the penis account for less than 5% of all tumors of the penis. They are dominated by Kaposi's sarcoma that mainly affects HIV-positive patients. However, recent studies have shown a relationship between Kaposi's sarcoma and HHV-8 infection (Human herpes virus-8), which explains why this sarcoma occurs in non-immunocompromised and HIV-seronegative patients. Read More

    One or two doses of live varicella virus-containing vaccines: Efficacy, persistence of immune responses, and safety six years after administration in healthy children during their second year of life.
    Vaccine 2018 Jan 7;36(3):381-387. Epub 2017 Dec 7.
    Vaccine Discovery and Development, GSK, Philadelphia, United States. Electronic address:
    Background: This phase III B follow-up of an initial multicenter study (NCT00226499) will evaluate the ten-year efficacy of two doses of the combined measles-mumps-rubella-varicella vaccine (MMRV) and one dose of the live attenuated varicella vaccine (V) versus a measles-mumps-rubella control group (MMR) for the prevention of clinical varicella disease. Here we present efficacy results for six years post-vaccination.

    Methods: In phase A of the study, healthy children aged 12-22 months from ten European countries were randomized (3:3:1) and received either two doses of MMRV, or one dose of combined MMR and one dose of monovalent varicella vaccine (MMR+V), or two doses of the MMR vaccine (control), 42 days apart. Read More

    [Acyclovir-resistant perineal HSV infection revealing chronic lymphoid leukaemia].
    Ann Dermatol Venereol 2017 Dec 5. Epub 2017 Dec 5.
    Dermatologie, université Paul-Sabatier, Hopital Larrey, CHU de Toulouse, 24 chemin de Pouvourville, 31300 Toulouse, France.
    Background: Chronic HSV infection is a cause of chronic perineal ulcerations. We report a case of a chronic and refractory HSV infection revealing chronic lymphoid leukaemia.

    Patients And Methods: An 85-year-old woman with an 8-month history of chronic perineal ulcerations was referred to our dermatology department. Read More

    Diagnostic Challenges in Nocardia Keratitis.
    Eye Contact Lens 2017 Dec 5. Epub 2017 Dec 5.
    Department of Ophthalmology, Visual Optics and Visual Rehabilitation (J.B., S.N.D., and C.K.), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerpen, Belgium; and Department of Ophthalmology (J.B., S.N.D., and C.K.), Antwerp University Hospital, Edegem, Belgium.
    Objective: To present a case of diagnostic confusion in Nocardia keratitis in a contact lens wearer and to illustrate the characteristic clinical findings of this rare entity.

    Methods: Case report of Nocardia keratitis that was mistaken for acanthamoeba, herpetic, and fungal keratitis in three tertiary corneal referral centers before the correct diagnosis of Nocardia infection was made.

    Results: A 29-year-old contact lens wearer was referred to our hospital for a contact lens-associated bacterial keratitis, not improving under standard bacterial treatment. Read More

    Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models.
    Oncol Rep 2018 Feb 5;39(2):721-730. Epub 2017 Dec 5.
    Genomic and Health/EDST-PRASE Laboratory, Faculty of Sciences, R. Hariri Campus, Lebanese University, Hadath 1003, Lebanon.
    Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant effusions in body cavities. PEL cells do not harbor conventional genetic cancer mutations; however, their oncogenesis is mainly attributed to HHV-8 latent genes. Treatment strategies are inefficient resulting in poor prognosis of PEL patients, stressing the need for new effective therapy. Read More

    Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells.
    PLoS Pathog 2017 Dec 4;13(12):e1006732. Epub 2017 Dec 4.
    Molecular Virology and Microbiology Graduate Program, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
    Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+ T cells (gB-CD8s) recognize a single epitope on glycoprotein B (gB498-505), while the remainder (non-gB-CD8s) recognize, in varying proportions, 19 subdominant epitopes on 12 viral proteins. The gB-CD8s remain functional in TG throughout latency, while non-gB-CD8s exhibit varying degrees of functional compromise. Read More

    Increased herpes zoster risk associated with poor HLA-A immediate early 62 protein (IE62) affinity.
    Immunogenetics 2017 Dec 1. Epub 2017 Dec 1.
    Antwerp Unit for Data Analysis and Computation in Immunology and Sequencing (AUDACIS), University of Antwerp, 2020, Antwerp, Belgium.
    Around 30% of individuals will develop herpes zoster (HZ), caused by the varicella zoster virus (VZV), during their life. While several risk factors for HZ, such as immunosuppressive therapy, are well known, the genetic and molecular components that determine the risk of otherwise healthy individuals to develop HZ are still poorly understood. We created a computational model for the Human Leukocyte Antigen (HLA-A, -B, and -C) presentation capacity of peptides derived from the VZV Immediate Early 62 (IE62) protein. Read More

    The Viral Hypothesis of Mesial Temporal Lobe Epilepsy - Is Human Herpes Virus-6 the Missing Link? A systematic review and meta-analysis.
    Seizure 2018 Jan 24;54:33-40. Epub 2017 Nov 24.
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, Sweden.
    Purpose: Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder. Although likely multifactorial, the mechanisms underlying the etiology and pathogenesis of the disease remains unknown in majority of patients. Viruses, particularly Human Herpes Virus 6A and B (HHV-6), two neurotropic herpes viruses, have been implicated in MTLE due to their ubiquitous nature and ability to establish lifelong latency with risk of reactivation. Read More

    The Interplay between Natural Killer Cells and Human Herpesvirus-6.
    Viruses 2017 Dec 1;9(12). Epub 2017 Dec 1.
    Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557, USA.
    Human Herpesvirus 6 (HHV-6) is a set of two closely related herpes viruses known as HHV-6A and HHV-6B. Both are lymphotropic viruses that establish latency in the host. The ability to evade the immune responses of effector cells is likely a major factor contributing to the development of a persistent HHV-6A/B (collectively termed HHV-6) infection. Read More

    An analysis of factors associated with influenza, pneumoccocal, Tdap, and herpes zoster vaccine uptake in the US adult population and corresponding inter-state variability.
    Hum Vaccin Immunother 2018 Feb 15;14(2):430-441. Epub 2017 Dec 15.
    d Department of Health Outcomes , GSK , Philadelphia , PA , USA.
    Despite longstanding recommendations for routine vaccination against influenza; pneumococcal; tetanus, diphtheria, acellular pertussis (Tdap); and herpes zoster (HZ) among the United States general adult population, vaccine uptake remains low. Understanding factors that influence adult vaccination and coverage variability beyond the national level are important steps toward developing targeted strategies for increasing vaccination coverage. A retrospective analysis was conducted using data from the Behavioral Risk Factor Surveillance System (2011-2014). Read More

    Ultrasound indications for maternal STORCH testing in pregnancy.
    Swiss Med Wkly 2017 Nov 29;147:w14534. Epub 2017 Nov 29.
    Department of Obstetrics, University Hospital Basel, Switzerland.
    Aims Of The Study: Fetal abnormalities found on ultrasonography lead to a variety of diagnostic procedures, including a panel of serologies to detect possible maternal STORCH infections encompassing syphilis, Toxoplasma gondii, rubella, cytomegalovirus, herpes simplex, and others (human immunodeficiency virus, hepatitis B and C, parvovirus B19, enterovirus, varicella zoster, and Leptospira interrogans). The value of indiscriminate testing for infections upon the detection of fetal ultrasound abnormalities has been questioned. The aim of this study was to review the ultrasonographic abnormalities leading to maternal STORCH panels at the obstetrics department of a university hospital. Read More

    Isosteric ribavirin analogues: Synthesis and antiviral activities.
    Bioorg Med Chem Lett 2018 01 15;28(1):11-14. Epub 2017 Nov 15.
    Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454 Moscow, Russia.
    The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism. Read More

    1 OF 126