3,334 results match your criteria Hepatorenal Syndrome


Predictive Value of Hepatorenal Status in Contrast-Induced Nephropathy Among Patients Receiving Coronary Angiography and/or Intervention: A Systematic Review and Meta-Analysis.

Angiology 2018 Dec 9:3319718816206. Epub 2018 Dec 9.

1 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background:: Low serum albumin, high blood urea nitrogen (BUN), and uric acid are regarded closely related to the incidence of contrast-induced nephropathy (CIN), whereas it remains unclear whether they can function as predictors of CIN onset. The objective of this systematic review and meta-analysis was to explore the association between abovementioned indicators and CIN incidence rate in patients receiving coronary angiography (CAG) and/or intervention.

Methods:: Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and ScienceDirect from their inception to July 13, 2018. Read More

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December 2018

Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone.

J Inflamm Res 2018 8;11:421-429. Epub 2018 Nov 8.

Department of Tropical, Faculty of Medicine, Tanta University, Tanta, Egypt,

Methotrexate (MTX) is a drug used in treatment of various malignancies. Unfortunately, it leads to life-threatening complications including hepatorenal toxicity. Previous studies revealed the protective effects of metformin (MET) on hepatorenal toxicity in other models in addition to its anticancer effects. Read More

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November 2018
1 Read

FGF21 underlies a hormetic response to metabolic stress in methylmalonic acidemia.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.

Methylmalonic acidemia (MMA), an organic acidemia characterized by metabolic instability and multiorgan complications, is most frequently caused by mutations in methylmalonyl-CoA mutase (MUT). To define the metabolic adaptations in MMA in acute and chronic settings, we studied a mouse model generated by transgenic expression of Mut in the muscle. Mut-/-;TgINS-MCK-Mut mice accurately replicate the hepatorenal mitochondriopathy and growth failure seen in severely affected patients and were used to characterize the response to fasting. Read More

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December 2018
2 Reads

[Preliminary report on prospective, multicenter, open research of selective surgery after expandable stent combined with neoadjuvant chemotherapy in the treatment of obstructive left hemicolon cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1233-1239

Department of General Surgery, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China.

Objective: To evaluate the safety and feasibility of neoadjuvant chemotherapy prior elective surgery following self-expanding metallic stents (SEMS) for complete obstructive left hemicolon cancer.

Methods: This prospective, multicenter, open-labelled trial was approved by the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University(2016-ke-161-1) and registered in Clinicaltrials.gov (NCT02972541). Read More

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November 2018

Production Inhibition and Excretion Promotion of Urate by Fucoidan from in Adenine-Induced Hyperuricemic Mice.

Mar Drugs 2018 Nov 27;16(12). Epub 2018 Nov 27.

College of Food Science & Technology, Guangdong Ocean University, Zhanjiang 524088, China.

This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of the drugs. Serum uric acid, urea nitrogen, hepatorenal functions, activities of hepatic adenosine deaminase (ADA), xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and NF-κB p65 were assessed. Read More

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November 2018
3 Reads

Terlipressin for the treatment of hepatorenal syndrome: An overview of current evidence.

Curr Med Res Opin 2018 Nov 25:1-22. Epub 2018 Nov 25.

a Department of Gastroenterology , General Hospital of Shenyang Military Area , Shenyang , China.

Hepatorenal syndrome (HRS) is a serious complication of liver cirrhosis, which is of pre-renal origin due to central volume depletion together with cardiac dysfunction and characterized by oliguria with severe urinary sodium retention and elevated serum creatinine levels. HRS is divided into HRS I, which is rapidly progressive and mostly seen in patients with decompensated liver cirrhosis, and HRS II, which progresses more slowly and is always accompanied by gross ascites. Liver transplantation is the best choice of treatment for HRS but rarely available. Read More

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November 2018
3 Reads

Place of death and factors associated with hospital death in patients who have died from liver disease in England: a national population-based study.

Lancet Gastroenterol Hepatol 2019 Jan 22;4(1):52-62. Epub 2018 Nov 22.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, King's College London, London, UK.

Background: Liver disease is a major cause of mortality, with high numbers of hospital deaths, and disproportionately affects people younger than 65 years. This study aims to examine the place of death and factors associated with hospital death for people who died from liver disease.

Method: We did a national population-based, observational study using the National Death Registration Database from the Office for National Statistics, 2001-14. Read More

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January 2019
8 Reads

Diagnosis and treatment of alcohol use disorder in patients with end-stage alcoholic liver disease.

Hepatology 2018 Nov 24. Epub 2018 Nov 24.

"G. Fontana" Centre for the Study and Multidisciplinary Treatment of Alcohol Addiction, Department of Medical and Surgical Sciences, University of Bologna, Italy.

Almost 14-30% of the world's population is affected by alcohol use disorder (AUD), and excessive alcohol consumption represents the most common cause of liver disease in the western world. The clinical picture of alcoholic end-stage liver disease is rendered extremely complex as manifestations such as alcohol withdrawal syndrome, craving and physical dependence, as well as extrahepatic alcohol-related diseases merge with the complications of advanced cirrhosis. This makes AUD recognition and assessment difficult and its management arduous as many drugs commonly employed to treat complications such as alcohol withdrawal syndrome are often contraindicated by the presence of hepatic encephalopathy or hepatorenal syndrome. Read More

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November 2018
6 Reads

Effect of different doses of ulinastatin on cellular immunity and hepatorenal functions in patients undergoing laparoscopic colorectalcarcinoma surgery.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2311-2314

First Affiliated Hospital of Jiamusi University, Jiamusi, China.

The effect of different doses of ulinastatin on cellular immunity and hepatorenal functions in patients undergoing laparoscopic colorectal-carcinoma surgery was observed and analyzed. The 200 patients with laparoscopic colorectal-carcinoma surgery in our hospital were selected as research subjects and divided into 4 groups containing equal patients, namely, saline group, 0.5 x 104U/kg ulinastatin group, 1 x 104U/kg ulinastatin group, and 1. Read More

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September 2018
1 Read

Population pharmacokinetics of oxcarbazepine active metabolite in Chinese paediatric epilepsy patients and its application in individualised dosage regimens.

Eur J Clin Pharmacol 2018 Nov 19. Epub 2018 Nov 19.

Department of Pharmacy, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Purpose: Oxcarbazepine (OXC) is an antiepileptic drug metabolised to active 10-monohydroxy derivative (MHD) following oral administration. There are no MHD population pharmacokinetic (PPK) models that describe the influence of genetic factors on MHD pharmacokinetics (PK). We developed a PPK model of MHD to investigate gene polymorphism of enzymes associated with MHD PK in Chinese paediatric epilepsy patients and evaluated its utility for dose individualisation. Read More

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November 2018

Protective effect of root against mercuric chloride-induced hepatorenal toxicity in rats.

Avicenna J Phytomed 2018 Nov-Dec;8(6):488-497

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The present study was designed to investigate the protective effects of hydroalcoholic extract of against HgCl hepatorenal toxicity in rats.

Materials And Methods: Animals were randomly divided into five groups (n= 6 in each group) and received HgCl and plant's extract, intraperitoneally. Group1 received saline (1 mL/kg/day), group 2 received extract (200 mg/kg/day), group 3 was treated with HgCl (5 mg/kg/day,) and groups 4 and 5 received the extract (100 and 200 mg/kg/day, respectively), 1 hr before HgCl administration. Read More

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November 2018
8 Reads

Acute Alcoholic Hepatitis.

Authors:
Gene Y Im

Clin Liver Dis 2019 Feb 26;23(1):81-98. Epub 2018 Oct 26.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Recanati-Miller Transplantation Institute, One Gustave Levy Place, Box 1104, New York, NY 10029, USA. Electronic address:

Alcoholic hepatitis is a unique type of alcohol-associated liver disease characterized by acute liver inflammation caused by prolonged heavy alcohol use. Treatment is mostly supportive. The short-term prognosis of acute alcoholic hepatitis depends on liver recovery, and ranges widely from rapid improvement to grim multiorgan failure despite treatment. Read More

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February 2019
5 Reads

Clinical pharmacokinetics of drugs in cardiopulmonary associated cachexia without hepatorenal pathology: a systematic review.

Drug Metab Rev 2018 Nov 18:1-11. Epub 2018 Nov 18.

b Department of Pharmacy , COMSATS Institute of Information Technology (CIIT) , Khyber Pakhtun Khwa , Abbottabad , Pakistan.

Cachexia not only has a dramatically harmful impact on a patient's life, but also a poor response to therapeutic agents. The purpose of the present review is to provide updated information concerning the pharmacokinetic aspects of drugs used to treat cardiopulmonary cachexia in patients with no signs of hepatic or renal pathology. A systematic search of PubMed, the Cochrane Central Register of Control Trials, Science Direct, and Clinical Trials Registry (ClinicalTrials. Read More

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November 2018
6 Reads

Albumin: The Cons.

Authors:
Alastair O'Brien

Liver Transpl 2018 Nov 17. Epub 2018 Nov 17.

Institute of Liver Disease and Digestive Health, University College London, UK.

Intravenous albumin infusions have long been considered an important option in the treatment of patients with cirrhosis and ascites . Many studies have shown that 20% Human Albumin Solution (HAS) improves circulatory function and it is therefore recommended in international guidelines worldwide for use in hepatorenal syndrome (HRS), spontaneous bacterial peritonitis (SBP), as well as in preventing post paracentesis circulatory dysfunction following large volume paracentesis (LVP) . Albumin has also been reported to have beneficial immunomodulatory and endothelial effects and therefore may have a particular beneficial role in sepsis . Read More

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November 2018
4 Reads

Establishment and evaluation of a model for predicting 3-month mortality in Chinese patients with hepatic encephalopathy.

Metab Brain Dis 2018 Nov 15. Epub 2018 Nov 15.

Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, 252004, China.

Hepatic encephalopathy (HE) is a serious complication of liver disease. To establish a model for predicting 3-month mortality in patients with HE in China. This retrospective study included 609 patients with HE admitted to the Peoples' Hospital, Liaocheng City, China (August 2006 to January 2016). Read More

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November 2018
7 Reads

Loss of paraspinal muscle mass is a gender-specific consequence of cirrhosis that predicts complications and death.

Aliment Pharmacol Ther 2018 Dec 11;48(11-12):1271-1281. Epub 2018 Nov 11.

Section Hepatology, Department of Gastroenterology and Rheumatology, University Hospital Leipzig, Leipzig, Germany.

Background: Loss of skeletal muscle mass is a recognised complication with a prognostic impact in patients with cirrhosis.

Aim: To explore in a retrospective analysis which muscle compartment most reliably predicts the occurrence of cirrhosis-associated complications and if there are gender-related differences.

Methods: 795 patients with cirrhosis listed for liver transplantation between 2001 and 2014 met the inclusion and exclusion criteria including an abdominal CT scan (±200). Read More

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December 2018
2 Reads

Predictors of incisional hernia in adult liver transplant recipients.

Hernia 2018 Nov 8. Epub 2018 Nov 8.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Purpose: Incisional hernia is a complication following abdominal operation. Patients undergoing liver transplantation have a high risk of developing incisional hernia because of immunosuppression. The purpose of this study was to evaluate incisional hernia after liver transplantation and to identify risk factors for hernia formation in those patients. Read More

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November 2018
4 Reads

Bile Cast Nephropathy: A Pathologic Finding with Manifold Causes Displayed in an Adult with Alcoholic Steatohepatitis and in a Child with Wilson's Disease.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):207-215. Epub 2018 Sep 27.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Bile cast nephropathy (BCN) is seen in patients who have acute kidney injury and severe hyperbilirubinemia due to a wide range of hepatobiliary system diseases. Findings seen by renal biopsy include acute tubular injury with necrotic and sloughed epithelial cells, yellow-green pigment within tubular epithelial cells, and pigmented granular casts. Hall's special stain for bile turns these casts green. Read More

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September 2018
6 Reads

[Severe reversible penile ischaemia after terlipressin treatment of hepatorenal syndrome].

Ugeskr Laeger 2018 Oct;180(43)

This case report presents a 70-year-old man with alcoholic liver cirrhosis, who was hospitalised due to pulmonary oedema, and who developed acute renal injury. Though the criteria were not fulfilled, hepatorenal syndrome was suspected and treated with terlipressin, after which the patient developed severe penile ischaemia. Hepatorenal syndrome is one of many potential causes of acute kidney injury in patients with acute or chronic liver disease. Read More

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October 2018
1 Read

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I.

Adv Mater 2018 Oct 25:e1805308. Epub 2018 Oct 25.

Simmons Comprehensive Cancer Center, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

mRNA-mediated protein replacement represents a promising concept for the treatment of liver disorders. Children born with fumarylacetoacetate hydrolase (FAH) mutations suffer from Hepatorenal Tyrosinemia Type 1 (HT-1) resulting in renal dysfunction, liver failure, neurological impairments, and cancer. Protein replacement therapy using FAH mRNA offers tremendous potential to cure HT-1, but is currently hindered by the development of effective mRNA carriers that can function in diseased livers. Read More

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October 2018
5 Reads

Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements.

Sci Rep 2018 Oct 24;8(1):15691. Epub 2018 Oct 24.

Endocrine Unit, "Aretaieion" Hospital, National and Kapodistrian University of Athens, Faculty of Medicine, Athens, Greece.

Children born with IUGR develop features of the metabolic syndrome and exhibit deranged markers of hepatorenal physiology. Metabolic and hepatorenal biochemistry and the rs9939609 FTO polymorphism were investigated in prepubertal children born with IUGR. Ninety-eight prepubertal children (46 IUGR and 52 AGA), subdivided in <5 years and >5 years old groups were included. Read More

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October 2018
5 Reads

Cholangitis Lenta Causing Bile Cast Nephropathy: A Unique Model of Hepatorenal Failure in Sepsis.

Fetal Pediatr Pathol 2018 Oct 23:1-9. Epub 2018 Oct 23.

a Mount Sinai Medical Center, Arkadi M. Rywlin M.D. , Department of Pathology and Laboratory Medicine , Miami Beach , FL , USA.

Introduction: Inadequate perfusion and abnormal cellular metabolism are among the mechanisms of organ dysfunction in sepsis. Concomitant hepatorenal failure during the late phase of sepsis is poorly understood.

Case Report: The autopsy of a child who developed sepsis-induced hepatorenal failure revealed bile cast nephropathy, hepatic centrilobular necrosis and cholangitis lenta, a type of sepsis-induced cholestasis, with no biliary obstruction, fibrosis or cirrhosis. Read More

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October 2018
4 Reads

Management of Infectious Complications Associated with Acute-on-Chronic Liver Failure.

Visc Med 2018 Aug 27;34(4):261-268. Epub 2018 Jul 27.

Section Hepatology, Department of Gastroenterology and Rheumatology, University Hospital Leipzig, Leipzig, Germany.

Introduction: Acute-on-chronic liver failure (ACLF) is associated with a high susceptibility to infections leading to complications and poor prognosis. The sensitized immune system overwhelmingly responds to invading bacteria leading to organ damage. After resolution of infection or prolonged disease duration, the phagocytic system becomes irresponsive with a reduced bacterial clearance capacity promoting secondary infection. Read More

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August 2018
4 Reads

Renal Failure in Patients with Liver Cirrhosis: Novel Classifications, Biomarkers, Treatment.

Visc Med 2018 Aug 14;34(4):246-252. Epub 2018 Aug 14.

Department of Internal Medicine II, University of Saarland, Homburg/Saar, Germany.

Renal failure is a severe complication in patients with liver cirrhosis. It is associated with increased mortality and morbidity. Diagnosis is a challenge because it is mainly based on serum creatinine, which does not seem to be an ideal measure of renal function in cirrhosis. Read More

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August 2018
12 Reads

Author Correction: Hepatorenal syndrome.

Nat Rev Dis Primers 2018 Oct 15;4(1):33. Epub 2018 Oct 15.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

The original version of this article omitted an initial from the name of contributing author Patrick S. Kamath, who was listed as Patrick Kamath. The article has now been corrected. Read More

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October 2018
1 Read

On-Treatment Improvement of MELD Score Reduces Death and Hepatic Events in Patients With Hepatitis B-Related Cirrhosis.

Am J Gastroenterol 2018 Nov 12;113(11):1629-1638. Epub 2018 Oct 12.

Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China.

Objectives: Antiviral treatment modifies the natural history of chronic hepatitis B (CHB)-related cirrhosis as reflected by improving Model for End-Stage Liver Disease (MELD) score over time. We evaluated the impact of on-treatment change of MELD score on clinical outcomes in patients with CHB-related cirrhosis.

Methods: Cirrhotic CHB patients who received entecavir and/or tenofovir disoproxil fumarate for at least 6 months in Hong Kong between 2005 and 2016 were identified. Read More

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November 2018
1 Read
10.760 Impact Factor

Effect of Ocimum basilicum leaves extract on acetaminophen-induced nephrotoxicity in BALB/c mice.

J Complement Integr Med 2018 Oct 12. Epub 2018 Oct 12.

Department of Biological Sciences, Faculty of Science, Beirut Arab University, Debbieh, Lebanon.

Background Acetaminophen (APAP) is one of the most widely used drugs to treat pain. Its overdose is lethal causing liver and kidney failure. Nephrotoxicity and hepatotoxicity are mostly due to the overproduction of reactive oxygen species. Read More

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October 2018
8 Reads

Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy.

Exp Mol Pathol 2018 Dec 9;105(3):293-310. Epub 2018 Oct 9.

Department of Histology and Cell Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Objectives: The repression of renal Farnesoid X Receptor (FXR) had been shown to result from lack of bile acid production from cirrhotic liver. We hypothesized that silymarin and rosuvastatin (Rvs) could have a hepatorenal therapeutic effects in hepatic nephropathy through induction of FXR.

Methods: Forty two male Wistar rats were used; naïve (n = 12); six of them were sacrificed after 4 weeks and six continued till the end of the experiment. Read More

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December 2018
7 Reads

Portal vein thrombosis prevalence and associated mortality in cirrhosis in a nationally representative inpatient cohort.

J Gastroenterol Hepatol 2018 Oct 11. Epub 2018 Oct 11.

Division of Gastroenterology and Hepatology, New York Presbyterian Hospital/Weill Cornell Medical College, New York, New York, USA.

Background And Aim: Portal vein thrombosis (PVT) is increasingly common in cirrhotics, but its impact on mortality and outcomes is unclear. Studies evaluating PVT have been limited by small sample size. This study analyzes the trend of the prevalence of PVT and its associated mortality in hospitalized decompensated cirrhotics. Read More

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October 2018
3 Reads

[Comparison of a commercially available, formula-based nutritional therapy enriched with oats fiber with a non-formula isocaloric therapy to treat non-alcoholic fatty liver disease (NAFLD) - a randomized, controlled intervention trial].

Z Gastroenterol 2018 Oct 10;56(10):1247-1256. Epub 2018 Oct 10.

Institut für Ernährungsmedizin, Universität Hohenheim, Stuttgart, Germany.

Non-alcoholic fatty liver disease (NAFLD) is mainly treated with caloric restriction and consecutive weight reduction. Protein, in exchange for starch and sugar as well as monounsaturated and long chain omega-3-fatty acids and prebiotic β-glucan, are thought to be supportive.In a randomized controlled intervention study, two different dietary concepts were tested regarding effects on intrahepatic lipid content as well as on biochemical parameters in patients with a body-mass-index (BMI) > 30 kg/m and signs of fatty liver disease. Read More

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October 2018

Acute Kidney Injury Due to Inferior Vena Cava Stenosis After Liver Transplantation: A Case Report About the Importance of Hepatic Vein Doppler Ultrasound and Clinical Assessment.

Can J Kidney Health Dis 2018 3;5:2054358118801012. Epub 2018 Oct 3.

Department of Anesthesiology and Intensive care, Centre Hospitalier de l'Université de Montréal, QC, Canada.

Rationale: Acute kidney injury (AKI) is a frequent complication after liver transplantation. In some patients, prompt intervention targeted at a specific etiology is of paramount importance.

Presenting Concerns Of The Patients: A 25 years old man with advanced liver cirrhosis caused by sclerosing cholangitis and autoimmune hepatitis underwent orthotopic liver transplantation. Read More

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October 2018
12 Reads

Intravascular leiomyoma with intracardiac extension associated with hepatorenal polycystic disease.

Anatol J Cardiol 2018 Oct;20(4):246-248

Department of Cardiology, Heart Institute, "Iuliu Hatieganu" University of Medicine and Pharmacy; Cluj-Napoca- Romania.

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October 2018
2 Reads

Uncommon manifestation of leptospirosis: a diagnostic challenge.

BMJ Case Rep 2018 Oct 7;2018. Epub 2018 Oct 7.

Professor, Department of Medicine, All India Institute of Medical Sciences, New Delhi.

Leptospirosis is a zoonotic disease commonly affecting the tropical countries. It may have protean clinical manifestations including hepatorenal dysfunction, myocarditis, pulmonary haemorrhage, meningitis, optic neuritis and rhabdomyolysis. Neurological manifestation of leptospirosis without the classical hepatorenal dysfunction is a rare entity. Read More

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October 2018
2 Reads

Hepatorenal protective effects of taurine and N-acetylcysteine against fipronil-induced injuries: The antioxidant status and apoptotic markers expression in rats.

Sci Total Environ 2019 Feb 25;650(Pt 2):2063-2073. Epub 2018 Sep 25.

Department of Zoology, Science College, King Saud University, Riyadh 11451, Saudi Arabia.

Fipronil (FPN), a commonly used phenylpyrazole pesticide can induce oxidative tissue damage following hazard usage. Due to the extensive household and commercial usage of FPN, its toxic effects on mammals received considerable attention. Finding the proper antioxidant that can overcome FPN-induced damage is essential. Read More

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February 2019
3 Reads
4.100 Impact Factor

Evaluation of Two Training Methods for Teaching the Abdominal Focused Assessment with Sonography for Trauma Technique (A-FAST) to First- and Second-Year Veterinary Students.

J Vet Med Educ 2018 Oct 4:1-16. Epub 2018 Oct 4.

Ultrasound techniques, including focused assessment with sonography for trauma (FAST) examinations, are commonly used in veterinary practice, making inclusion of ultrasound in veterinary curricula increasingly important. The best approach for teaching ultrasound techniques in veterinary medicine has not been evaluated. This study compared the results of two training techniques, live-animal training and online video instruction, on students' performance during abdominal FAST (A-FAST) examinations. Read More

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October 2018
1 Read

Rifaximin has the potential to prevent complications of cirrhosis.

Therap Adv Gastroenterol 2018 28;11:1756284818800307. Epub 2018 Sep 28.

Virginia Commonwealth University, Richmond, VA, USA.

Background: Cirrhosis-related complications are associated with poor prognosis. With our analyses, we examined the potential benefit of rifaximin in reducing the risk of developing cirrhosis-related complications.

Methods: Adults with cirrhosis and hepatic encephalopathy (HE) in remission were randomly assigned to receive rifaximin 550 mg twice daily or placebo for 6 months with concomitant lactulose permitted. Read More

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September 2018
9 Reads

Hepatorenal protection during renal ischemia by quercetin and remote ischemic perconditioning.

J Surg Res 2018 Nov 22;231:224-233. Epub 2018 Jun 22.

Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.

Background: Pathogenesis of renal ischemia/reperfusion injury (IRI) involves oxidative stress response in the kidney and remote organs. Both quercetin and remote ischemic perconditioning (RIPerC) can protect partially against IRI. This study determined whether combined quercetin and RIPerC could provide an augmented hepatorenal protection against renal IRI. Read More

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November 2018
1 Read

Noradrenaline for reverting hepatorenal syndrome: a prospective, observational, single-center study.

Clin Exp Gastroenterol 2018 18;11:317-324. Epub 2018 Sep 18.

Department of Internal Medicine, Lady Hardinge Medical College, New Delhi, India,

Objective: To evaluate the effectiveness of noradrenaline for the treatment of hepatorenal syndrome (HRS).

Background: HRS represents the development of renal failure in cirrhotic patients. The standard treatment for HRS is terlipressin, which, as opposed to noradrenaline, is more expensive and less accessible in most tertiary care centers. Read More

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September 2018
2 Reads

Clinical characteristics of patients with liver cirrhosis and spontaneous portosystemic shunts detected by ultrasound in a tertiary care and transplantation centre.

Scand J Gastroenterol 2018 Sep 29;53(9):1107-1113. Epub 2018 Sep 29.

a Department of Gastroenterology, Hepatology and Endocrinology , Hannover Medical School , Hannover , Germany.

Objectives: The clinical relevance of spontaneous portosystemic shunts detected by ultrasound is insufficiently investigated. The aim of this retrospective study was to assess the frequency and clinical relevance of spontaneous portosystemic shunts in patients with liver cirrhosis.

Methods: We evaluated portosystemic shunts, liver cirrhosis and spleen size by ultrasound in 982 patients with liver cirrhosis and correlated these with laboratory results, clinical data and the incidence of clinical endpoint deaths, liver transplantation and the development of HCC during the follow-up period (mean 1. Read More

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September 2018
7 Reads

Renal complications of liver diseases.

Expert Rev Gastroenterol Hepatol 2018 Oct 1. Epub 2018 Oct 1.

a Service de Néphrologie, Hémodialyse , Aphérèses et Transplantation rénale, Grenoble-Alpes , France.

Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are the major causes of chronic liver disease. HBV and HCV affect nearly 7% of the world's population. Extra-hepatic complications and particularly renal failure have different mechanisms and manifestations. Read More

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October 2018
5 Reads

Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice.

Oxid Med Cell Longev 2018 5;2018:1630751. Epub 2018 Sep 5.

Research Unit of Macromolecular Biochemistry and Genetic, Faculty of Sciences of Gafsa, 2112 Gafsa, Tunisia.

This study was designed to assess the protective effects of methanol extract (LEM) on liver and kidney injuries induced by cisplatin. The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated. Results revealed that LEM exhibited a significant antioxidant activity on DPPH radical and HO scavenging assays. Read More

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November 2018
13 Reads

Pediatric hepatocellular carcinoma.

World J Gastroenterol 2018 Sep;24(35):3980-3999

Department of Pediatrics, King George Medical University, Uttar Pradesh 226003, India.

Pediatric hepatocellular carcinoma (HCC) is the second common malignant liver tumor in children after hepatoblastoma. It differs from the adult HCC in the etiological predisposition, biological behavior and lower frequency of cirrhosis. Perinatally acquired hepatitis-B virus, hepatorenal tyrosinemia, progressive familial intrahepatic cholestasis, glycogen storage disease, Alagille's syndrome and congenital portosystemic shunts are important predisposing factors. Read More

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September 2018
11 Reads

Promising utilization areas of therapeutic plasmapheresis in cardiovascular surgery practice.

Transfus Apher Sci 2018 Dec 18;57(6):762-767. Epub 2018 Sep 18.

Department of Cardiovascular Surgery, Heart Center, Cebeci Hospitals, Ankara University School of Medicine, Ankara, Turkey.

Objective: Apheresis is performed for treatment of numerous diseases by removing auto-antibodies, antigen-antibody complexes, allo-antibodies, paraproteins, non-Ig proteins, toxins, exogenous poisons. In current study, we present our experience of using therapeutic plasma exchange (TPE) in patients with different types of clinical scenarios.

Methods: Between January 2013 and May 2016, we retrospectively presented the results of 64 patients in whom postoperative TPE was performed in ICU setting after cardiac surgery. Read More

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December 2018
8 Reads

Safety and Efficacy of Rifaximin in Prophylaxis of Spontaneous Bacterial Peritonitis: Is this time to abandon fluoroquinolones for prevention of spontaneous bacterial peritonitis? : A Systematic Review.

Curr Drug Targets 2018 Sep 24. Epub 2018 Sep 24.

Department of Tropical Medicine & Infectious Diseases, Faculty of Medicine, Tanta University, Tanta. Egypt.

Aim: The role of rifaximin in the prevention of spontaneous bacterial peritonitis(SBP) is not well studied. The aim of this meta-analysis was to evaluate the role of rifaximin in the prevention of SBP.

Methods: A computerized literature search for relevant clinical trials was conducted during August 2017. Read More

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September 2018
1 Read
3.020 Impact Factor

A splice site variant in INPP5E causes diffuse cystic renal dysplasia and hepatic fibrosis in dogs.

PLoS One 2018 20;13(9):e0204073. Epub 2018 Sep 20.

Pathology Research Unit, Finnish Food Safety Authority, Evira, Helsinki, Finland.

Ciliopathies presenting as inherited hepatorenal fibrocystic disorders are rare in humans and in dogs. We describe here a novel lethal ciliopathy in Norwich Terrier puppies that was diagnosed at necropsy and characterized as diffuse cystic renal disease and hepatic fibrosis. The histopathological findings were typical for cystic renal dysplasia in which the cysts were located in the straight portion of the proximal tubule, and thin descending and ascending limbs of Henle's loop. Read More

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September 2018
1 Read

Long-term administration of human albumin improves survival in patients with cirrhosis and refractory ascites.

Liver Int 2018 Sep 19. Epub 2018 Sep 19.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine-DIMED, University of Padova, Padova, Italy.

Background & Aims: In patients with cirrhosis, the clinical benefit of the treatment with human albumin for ascites is debated, and no data are available regarding refractory ascites. In this study, in patients with cirrhosis and refractory ascites, we assessed the effect of long-term albumin administration on emergent hospitalization and mortality.

Methods: Seventy patients with cirrhosis and refractory ascites, followed at the Unit of Internal Medicine and Hepatology, University and General Hospital of Padova, Italy, were included into the study. Read More

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September 2018
6 Reads

Noradrenaline for Hepatorenal Syndrome in Patients With Acute on Chronic Liver Failure: Hope Remains!

Authors:
Sandeep Satsangi

Hepatology 2018 Dec;68(6):2443-2444

Global Integrated Liver Care, BGS Gleneagles Global Hospital, Bangalore, India.

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December 2018
4 Reads
11.050 Impact Factor

A systematic review and meta-analysis of treatment for hepatorenal syndrome with traditional Chinese medicine.

Transl Gastroenterol Hepatol 2018 22;3:57. Epub 2018 Aug 22.

Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang 110016, China.

Background: Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage liver diseases. It has been reported that traditional Chinese medicine (TCM) may improve liver function, delay disease progression, alleviate symptoms, and improve quality of life in HRS patients. The study aims to systematically review the efficacy of TCM for the treatment of HRS. Read More

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August 2018
5 Reads

Hepatorenal Syndrome or Hepatocardiorenal Syndrome: Revisiting Basic Concepts in View of Emerging Data.

Cardiorenal Med 2018 Sep 17;9(1):1-7. Epub 2018 Sep 17.

Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.

Background: Accumulating evidence on the pathophysiology of hepatorenal syndrome has challenged the conventional model of liver-kidney connection. While liver cirrhosis is traditionally considered the origin of a cascade of pathophysiologic mechanisms directly affecting other organs such as the kidney, emerging data point to the heart as the potential mediator of the untoward renal effects.

Summary: Herein, we briefly review the often-overlooked contribution of the heart to circulatory dysfunction in hepatorenal syndrome and put forward evidence arguing for the involvement of systemic inflammation and endothelial dysfunction in this setting. Read More

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September 2018
15 Reads

Copeptin as a novel marker predicting prognosis of liver cirrhosis and its major complications.

Hepat Med 2018 4;10:87-93. Epub 2018 Sep 4.

Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Tanta University, Tanta, Egypt,

Objectives: The aim of the work was to assess the level of copeptin as a surrogate marker predicting the severity of liver diseases and its major complications.

Patients And Methods: This was a cross-sectional study that included 40 patients and 10 controls and was performed in Tanta University Hospital between June 2016 and November 2016. The studied cases were divided into five groups: group I (10 patients): compensated cirrhosis; group II (10 patients): cirrhosis with gastrointestinal hemorrhage due to portal hypertension; group III (10 patients): cirrhosis with hepatorenal syndrome; group IV (10 patients): cirrhosis with liver cell failure; and group V (10 controls): normal healthy individuals. Read More

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September 2018
2 Reads