2,970 results match your criteria Hepatology Research[Journal]


Prediction of risk of falls based on handgrip strength in chronic liver disease patients living independently.

Hepatol Res 2019 Feb 16. Epub 2019 Feb 16.

Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.

Background/aim: Falling is known to be associated with cognitive function. We evaluated the relationship between muscle function and falls in patients with chronic liver disease (CLD).

Materials/methods: We enrolled 100 sequential CLD patients without dementia who were admitted to our institution for scheduled treatment from July 2017 to May 2018 [71. Read More

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http://dx.doi.org/10.1111/hepr.13322DOI Listing
February 2019
1 Read

Clinical and pathological features of sarcopenia-related indices in patients with nonalcoholic fatty liver disease.

Hepatol Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto.

Background: Sarcopenia is diagnosed with the skeletal muscle index (SMI) or the sarcopenia index (SI). We previously reported that the ratio of skeletal muscle mass to body fat mass (SF ratio) was a novel index of sarcopenia in patients with nonalcoholic fatty liver disease (NAFLD). The aim of this retrospective study was to evaluate sarcopenia with these indices in patients with NAFLD. Read More

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http://dx.doi.org/10.1111/hepr.13321DOI Listing
February 2019

Risk-benefit point of the model for end-stage liver disease score in patients waiting for deceased-donor liver transplantation: a single-center experience.

Hepatol Res 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Aim: To clarify the risk-benefit point of the model for end-stage liver disease (MELD) score in patients waiting for deceased-donor liver transplantation (DDLT).

Patients And Methods: The present study retrospectively investigated 213 patients registered on the waiting list at Kyoto University between 2005 and 2016. Patients were stratified by MELD score (6-9/10-14/15-20/21-30/31-40) and classified into two groups: the DDLT group (30 patients) and the waiting group (183 patients). Read More

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http://dx.doi.org/10.1111/hepr.13320DOI Listing
January 2019

CD4 T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T cell receptor repertoires.

Hepatol Res 2019 Jan 28. Epub 2019 Jan 28.

Division of Advanced Genome Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Aim: Primary biliary cholangitis (PBC) is an autoimmune liver disease with unknown pathogenesis. In PBC, activation of T cell receptor (TCR) signaling is associated with inflammatory cytokine production via N-Ras upregulation. Although CD4 T cell TCR repertoire may be associated with PBC pathogenesis, it has not been evaluated. Read More

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http://dx.doi.org/10.1111/hepr.13318DOI Listing
January 2019
1 Read

Comparison of liver stiffness assessment by transient elastography and shear wave elastography using six ultrasound devices.

Hepatol Res 2019 Jan 24. Epub 2019 Jan 24.

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, Japan, 663-8501.

Aim: Transient elastography (TE) is the gold standard for measurement of liver stiffness. The usefulness of shear wave elastographies (SWE) is well-accepted. However, the measurement values cannot be equivalently compared because cut off values for the diagnosis of liver fibrosis are different among those devices. Read More

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http://doi.wiley.com/10.1111/hepr.13319
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http://dx.doi.org/10.1111/hepr.13319DOI Listing
January 2019
5 Reads

Vitamin A-coupled liposomal Rho-kinase inhibitor ameliorates liver fibrosis without systemic adverse effects.

Hepatol Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Aim: Rho-kinase (ROCK) inhibitor could ameliorate liver fibrosis by suppressing hepatic stellate cell (HSC) activation. However, because systemic administration of ROCK inhibitor causes serious adverse effects, we developed a drug delivery system selectively delivering ROCK inhibitor to HSCs. Here, we examined whether our developed vitamin A (VA)-coupled liposomal ROCK inhibitor reduced liver fibrosis in rats without causing systemic adverse effects. Read More

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http://dx.doi.org/10.1111/hepr.13317DOI Listing
January 2019

Protective effects of gastrin-releasing peptide receptor antagonist RC-3095 in an animal model of hepatic ischemia/reperfusion injury.

Hepatol Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aim: We aimed to evaluate effects of RC-3095 on mice with hepatic ischemia followed by reperfusion (I/R) injury and further explore the possible underlying mechanism.

Methods: Mice were subjected to partial hepatic ischemia for 60 min followed by different durations of reperfusion. Levels of gastrin-releasing peptide (GRP) and GRP receptor (GRPR) in the blood and liver were detected by enzyme-linked immunosorbent assay (ELISA) or western blotting (WB) after 3, 6, 12, or 24 h of reperfusion. Read More

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http://dx.doi.org/10.1111/hepr.13315DOI Listing
January 2019
1 Read

Outbreak of hepatitis A linked to European outbreaks among men who have sex with men in Osaka, Japan, from March to July 2018.

Hepatol Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka City, Osaka, 540-0006, Japan.

Aim: Ongoing hepatitis A outbreaks among men who have sex with men (MSM) have been reported worldwide, mainly in Europe, since 2016. In Japan, there has been an increase in the number of notified hepatitis A cases since January 2018, most of which were suspected to have been transmitted via homosexual contact. In this paper, we describe the current outbreak situation of hepatitis A among MSM. Read More

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http://dx.doi.org/10.1111/hepr.13314DOI Listing
January 2019
1 Read

Full-genome characterization of the RIVM-HAV16-090-like hepatitis A virus strains recovered from Japanese men who have sex with men, with sporadic acute hepatitis A.

Hepatol Res 2019 Jan 15. Epub 2019 Jan 15.

Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.

Aim: The major transmission mode of hepatitis A virus (HAV) in Japan is the fecal-oral route by contaminated foods. In contrast, HAV infection is well documented as a sexually transmitted disease in Europe and North America. The present study was undertaken to determine the full-genome sequence of HAV and trace the transmission route of HAV in Japanese men who have sex with men (MSM). Read More

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http://dx.doi.org/10.1111/hepr.13313DOI Listing
January 2019
2 Reads

Utility of ultrasound-guided liver tumor biopsy for next-generation sequencing-based clinical sequencing.

Hepatol Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Aim: Recent advances in next-generation sequencing (NGS) technologies allow for evaluation of genetic alterations in various cancer-related genes in daily clinical practice. Archival formalin-fixed paraffin-embedded (FFPE) tumor tissue is often used for NGS-based clinical sequencing assays; however, the success rate of NGS assays using archival FFPE tumor tissue is reported to be lower than that using fresh tumor tissue. We aimed to evaluate the feasibility and safety of ultrasound (US)-guided liver tumor biopsy for NGS-based multiplex gene assays. Read More

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http://dx.doi.org/10.1111/hepr.13312DOI Listing
January 2019
1 Read

Influence of renal dysfunction on dose reduction and virologic efficacy of regimens combining ribavirin and all-oral direct acting antivirals in patients with chronic hepatitis C virus infection.

Hepatol Res 2019 Jan 10. Epub 2019 Jan 10.

Department of Nursing, Ogaki Women's College, Ogaki, Japan.

Aim: Several interferon (IFN)-free, all-oral regimens with direct acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection also include ribavirin (RBV). We investigated the influence of renal dysfunction on virologic efficacy and adverse effects in 189 patients with HCV genotype 2 infection who received combination RBV-DAA regimens.

Methods: The incidence of RBV-induced anemia, RBV dose reduction, and virologic efficacy were compared according to baseline renal function as defined by the estimated glomerular filtration rate (eGFR). Read More

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http://dx.doi.org/10.1111/hepr.13311DOI Listing
January 2019
1 Read

Risk factors for loss of skeletal muscle mass in patients with cirrhosis.

Hepatol Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Aim: The present study aimed to assess the correlation between loss of skeletal muscle mass (LSMM) and the clinical characteristics of patients with liver cirrhosis.

Methods: This multicenter, prospective study was undertaken at five locations in Japan and involved a 12-month observation period. After baseline assessment, the change in the skeletal muscle index per year (ΔSMI/y) was evaluated in the enrolled patients; LSMM was defined as ΔSMI/y < 0. Read More

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http://dx.doi.org/10.1111/hepr.13308DOI Listing
January 2019
1 Read

Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma.

Hepatol Res 2019 Jan 8. Epub 2019 Jan 8.

Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Aim: Phospholipase C-γ1 (PLCG1) was previously found to be involved in a variety of oncogenic behaviors such as cell motility, cell proliferation, cell migration, and invasion. However, its function in hepatocellular carcinoma (HCC) was unknown. Here, we explored the expression pattern and function of PLCG1 in HCC progression. Read More

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http://doi.wiley.com/10.1111/hepr.13309
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http://dx.doi.org/10.1111/hepr.13309DOI Listing
January 2019
4 Reads

Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response.

Hepatol Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita.

Aim: In patients with chronic hepatitis C, hepatocellular carcinoma (HCC) occurs at a certain frequency, even if a sustained virologic response (SVR) is achieved by antiviral treatment. Old age, liver fibrosis, and high post-treatment α-fetoprotein (AFP) level are typical risk factors of post-SVR HCC. We examined whether the frequencies and factors of HCC in patients with an SVR achieved from interferon treatment changed. Read More

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http://doi.wiley.com/10.1111/hepr.13310
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http://dx.doi.org/10.1111/hepr.13310DOI Listing
January 2019
2 Reads

Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents.

Hepatol Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Aim: Although the efficacy of hepatitis C virus (HCV) treatment is improved dramatically by direct-acting antiviral agents (DAAs), the assessment of hepatocellular carcinoma (HCC) remains important. Interferon lambda 3 (IFN-λ3) is associated with liver fibrosis and inflammation in chronic hepatitis C (CHC) patients, but its impact on carcinogenesis remains controversial and little is known about its effects after viral clearance. To determine the contribution of IFN-λ3 to hepatocarcinogenesis after HCV clearance, we analyzed IFNL3 genotypes and serial serum IFN-λ3 levels in CHC patients who achieved sustained virologic responses (SVR). Read More

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http://dx.doi.org/10.1111/hepr.13307DOI Listing
January 2019

Efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation in patients with recurrent hepatocellular carcinoma and thrombocytopenia.

Hepatol Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan.

Aims: Thrombocytopenia is often associated with chronic liver disease. Lusutrombopag is a small molecule thrombopoietin receptor agonist designed to temporarily increase the platelet count in patients with chronic liver disease for whom elective invasive procedures are planned. In the present study, the efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma were examined. Read More

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http://dx.doi.org/10.1111/hepr.13305DOI Listing
January 2019

Portal hypertension in hepatitis B-related cirrhosis: Diagnostic accuracy of liver and spleen stiffness by 2-D shear-wave elastography.

Hepatol Res 2018 Dec 29. Epub 2018 Dec 29.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

Aim: To assess the diagnostic accuracy of liver and spleen stiffness measured by 2-D shear-wave elastography (SWE) in evaluation of clinically significant and severe portal hypertension (CSPH and SPH, respectively).

Methods: Clinical data of 155 hepatitis B-related cirrhosis patients and their liver and spleen stiffness (L-SWE and S-SWE, respectively) were collected. The diagnostic performances of L-SWE, S-SWE, the liver stiffness-spleen diameter to platelet ratio score (LSPS) and portal hypertension risk score were evaluated. Read More

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http://dx.doi.org/10.1111/hepr.13306DOI Listing
December 2018
2 Reads

Rifaximin-altered gut microbiota components associated with liver/neuropsychological functions in patients with hepatic encephalopathy: An exploratory data analysis of phase II/III clinical trials.

Hepatol Res 2018 Dec 27. Epub 2018 Dec 27.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.

Aims: Rifaximin (RFX), a non-systemic antibiotic, improves liver/neuropsychological functions in patients with hepatic encephalopathy (HE). We aimed to investigate the clinical profiles associated with gut bacterial loads using exploratory data analysis and the effects of RFX on the gut microbiota of patients with HE.

Methods: We analyzed the data from 17 patients with HE who underwent fecal microbiota examination in phase II/III trials in Japan. Read More

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http://doi.wiley.com/10.1111/hepr.13300
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http://dx.doi.org/10.1111/hepr.13300DOI Listing
December 2018
2 Reads

Impact of sodium glucose cotransporter 2 inhibitor on histological features and glucose metabolism of non-alcoholic fatty liver disease complicated by diabetes mellitus.

Hepatol Res 2018 Dec 21. Epub 2018 Dec 21.

Department of Hepatology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan.

Aim: The aim of this study was to investigate the therapeutic potential of sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective therapeutic option for non-alcoholic fatty liver disease (NAFLD).

Methods: In this prospective study, nine patients with NAFLD complicated by type 2 diabetes mellitus (DM), were introduced to the regimen of canagliflozin 100 mg once daily for 24 weeks and were evaluated by liver histology at pretreatment and at 24 weeks after the start of treatment. The primary outcome was histological improvement, defined as a decrease in NAFLD activity score of one point or more without worsening in fibrosis stage. Read More

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http://doi.wiley.com/10.1111/hepr.13304
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http://dx.doi.org/10.1111/hepr.13304DOI Listing
December 2018
16 Reads

Acute liver failure due to severe Herpes simplex viral hepatitis in an elderly woman: A case of initial infection.

Hepatol Res 2018 Dec 21. Epub 2018 Dec 21.

Department of Gastroenterology, Saiseikai Kanazawa Hospital, Kanazawa.

The high mortality rate due to severe Herpes simplex viral (HSV) hepatitis is associated with the difficulty of its diagnosis. We describe the extremely rapid disease course of a patient who died of severe HSV hepatitis. A 73-year-old woman was admitted for a bronchial asthma attack. Read More

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http://doi.wiley.com/10.1111/hepr.13301
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http://dx.doi.org/10.1111/hepr.13301DOI Listing
December 2018
19 Reads
2.218 Impact Factor

Rescue therapy for chronic hepatitis C virus infection after repeated treatment failures: Impact on disease progression and risk of hepatocellular carcinoma.

Hepatol Res 2018 Dec 20. Epub 2018 Dec 20.

Department of Tropical Medicine, Tanta University, Tanta, Egypt.

Aim: Retreatment after previous failure of direct-acting antivirals for hepatitis C virus (HCV) infection is a challenging decision. The importance of achieving viral eradication on modification of disease progression and outcome, including the risk of hepatocellular carcinoma (HCC), remains a critical issue to be evaluated.

Methods: One hundred patients with repeated failure of sofosbuvir and ribavirin or triple therapy with sofosbuvir, ribavirin, and daclatasvir were divided into a study group (n = 50) given rescue therapy (sofosbuvir, daclatasvir, simeprevir, and ribavirin) or a control group (n = 50) matched for age, sex, and pretreatment variables (Child-Turcotte-Pugh score and Fibrosis-4 score). Read More

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http://dx.doi.org/10.1111/hepr.13303DOI Listing
December 2018
2.218 Impact Factor

Ischemic complications after percutaneous radiofrequency ablation of liver tumors: Liver volume loss and recovery.

Hepatol Res 2018 Dec 20. Epub 2018 Dec 20.

Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Aim: The liver regrows after acute liver injury and liver resection. However, it is not clear whether the liver regenerates in advanced cirrhosis. This study aimed to evaluate the clinical course of, and liver volume change after, ischemic liver complications caused by radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1111/hepr.13302DOI Listing
December 2018
1 Read

Analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan.

Hepatol Res 2019 Jan;49(1):105-110

Department of Gastroenterology and Hepatology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Aim: In order to know the present status of drug-induced liver injury (DILI) in Japan, we present the data of prospectively collected DILI cases between 2010 and 2018 from 27 hospitals.

Methods: Drug-induced liver injury cases diagnosed by DILI experts from 27 hospitals all over Japan have been prospectively collected since 2010. Alanine aminotransferase level ≥150 U/L and/or alkaline phosphatase ≥2× upper limit of normal were inclusion criteria. Read More

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http://doi.wiley.com/10.1111/hepr.13288
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http://dx.doi.org/10.1111/hepr.13288DOI Listing
January 2019
8 Reads
2.218 Impact Factor

Inhibition of glycogen synthase kinase 3β protects liver against ischemia/reperfusion injury by activating 5' adenosine monophosphate-activated protein kinase-mediated autophagy.

Hepatol Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Aim: Autophagy has been found to play an important role in hepatic ischemia/reperfusion (I/R) injury. Our previous study has also clarified that rictor deficiency aggravated hepatic I/R injury by suppressing autophagy. Here, we explore whether autophagy participates in glycogen synthase kinase 3β (GSK3β)-mediated cytoprotection in liver I/R. Read More

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http://dx.doi.org/10.1111/hepr.13287DOI Listing
November 2018
7 Reads

Presence of varices in patients after hepatitis C virus eradication predicts deterioration in the FIB-4 index.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Aims: The liver function of patients with hepatitis C virus (HCV) infection who obtained sustained virologic response (SVR) has been known to improve after HCV eradication. However, a predictor of liver function after SVR has not been definitively identified. The aim of this retrospective study was to identify a predictor of deteriorated liver function and Fibrosis-4 (FIB-4) index after SVR was achieved by direct-acting antiviral (DAA) treatment. Read More

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http://dx.doi.org/10.1111/hepr.13296DOI Listing
December 2018
2 Reads

Liver resection versus transcatheter arterial chemoembolization for the treatment of patients with hepatocellular carcinoma and hepatic vein or inferior vena cava tumor thrombus: A propensity score matching analysis.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China.

Aim: Because of the rarity of hepatic vein tumor thrombus (HVTT) in patients with hepatocellular carcinoma (HCC), little is known about HVTT. Thus, the survival benefit of liver resection (LR) versus transcatheter arterial chemoembolization (TACE) for HCC patients with HVTT or inferior vena cava tumor thrombus (IVCTT) remains controversial. We aimed to explore the survival benefits of LR versus TACE for the treatment of these patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.13297
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http://dx.doi.org/10.1111/hepr.13297DOI Listing
December 2018
8 Reads
2.218 Impact Factor

Primary liver carcinoma with sarcomatous changes: Analysis of 10 cases.

Hepatol Res 2018 Dec 7. Epub 2018 Dec 7.

Department of Hepatology, Toranomon Hospital, Tokyo.

Primary liver carcinoma with sarcomatous change is a rare malignancy associated with high aggressiveness and poor prognosis. However, the characteristics of these types of tumors are still unknown. The aim of this study was to assess the imaging features, prognostic significance, and clinicopathological characteristics of patients with these tumors. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.13295
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http://dx.doi.org/10.1111/hepr.13295DOI Listing
December 2018
7 Reads

Long-term antitumor effect of lenvatinib on unresectable hepatocellular carcinoma with portal vein invasion.

Hepatol Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka.

Lenvatinib is a novel multikinase inhibitor that has recently shown antitumor activity against hepatocellular carcinoma (HCC) in a phase III trial. We report the case of a woman in whom lenvatinib showed long-term antitumor activity, and in whom computed tomography (CT) scans revealed a series of suggestive radiological changes on the intratumor vascularity. A 68-year-old woman with hepatitis C virus-related liver disease presented with multiple HCCs. Read More

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http://dx.doi.org/10.1111/hepr.13294DOI Listing
November 2018
4 Reads

Liver resection for recurrent hepatocellular carcinoma after radiofrequency ablation therapy.

Hepatol Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Digestive Surgery, Nihon University School of Medicine, Tokyo.

Aim: Although radiofrequency ablation (RFA) is an effective local treatment of hepatocellular carcinoma (HCC), local recurrence is relatively frequent. We aimed to elucidate the validity of salvage liver resection for recurrent HCC after RFA.

Methods: Patients who underwent liver resection for recurrent HCC after RFA (LR after RFA) and those who underwent second liver resection for recurrent HCC (second LR) were included. Read More

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http://doi.wiley.com/10.1111/hepr.13293
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http://dx.doi.org/10.1111/hepr.13293DOI Listing
November 2018
1 Read

Efficacy and safety of ombitasvir/paritaprevir/ritonavir and ribavirin for chronic hepatitis patients infected with genotype 2a in Japan.

Hepatol Res 2018 Nov 28. Epub 2018 Nov 28.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo.

Aim: The aim of this study was to evaluate the efficacy and safety of community-based ombitasvir/paritaprevir/ritonavir plus ribavirin therapy for non-cirrhotic patients with hepatitis C virus (HCV) genotype 2a infection in a real-world setting.

Methods: Patients with HCV genotype 2a infection were enrolled in this study and received the therapy for 16 weeks at 11 specialized centers in Japan between October 2016 and July 2017. Among the 98 patients participating in the study, four patients were excluded because of the presence of cirrhosis and/or genotype 2b infection. Read More

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http://dx.doi.org/10.1111/hepr.13292DOI Listing
November 2018
9 Reads

Changes in serum levels of leucine-rich α2-glycoprotein predict prognosis in primary biliary cholangitis.

Hepatol Res 2018 Nov 24. Epub 2018 Nov 24.

Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Aims: A non-invasive biomarker for patients with primary biliary cholangitis (PBC) is needed. The association between leucine-rich α2 glycoprotein (LRG) and PBC has not been investigated. We aimed to assess the predictive value of LRG for the development of cirrhosis-related conditions in PBC. Read More

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http://doi.wiley.com/10.1111/hepr.13291
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http://dx.doi.org/10.1111/hepr.13291DOI Listing
November 2018
9 Reads

Efficiency of acoustic radiation force impulse imaging for the staging of graft fibrosis after liver transplantation.

Hepatol Res 2018 Nov 24. Epub 2018 Nov 24.

Department of Surgery, Graduate School of Medicine Kyoto University, Kyoto, Japan.

Aim: Liver biopsy is the gold standard for assessing liver fibrosis (LF) after liver transplantation (LT), but its invasiveness limits its utility. This study aimed to evaluate the usefulness of liver stiffness measurement (LSM) using acoustic radiation force impulse (ARFI) imaging to assess LF after LT.

Methods: Between September 2013 and January 2017, 278 patients who underwent liver biopsy after LT in Kyoto University Hospital (Kyoto, Japan) were prospectively enrolled. Read More

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http://dx.doi.org/10.1111/hepr.13289DOI Listing
November 2018
8 Reads

Non-invasive liver fibrosis assessment correlates with collagen and elastic fiber quantity in patients with hepatitis C virus infection.

Hepatol Res 2019 Jan 26;49(1):33-41. Epub 2018 Dec 26.

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.

Aim: Elastic fiber deposition is a cause of irreversibility of liver fibrosis. However, to date, its relevance to clinical features has not yet been clarified. This study aimed to clarify the correlation between non-invasive markers of fibrosis and fiber quantity, including elastic fiber, obtained from computational analysis. Read More

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http://doi.wiley.com/10.1111/hepr.13286
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http://dx.doi.org/10.1111/hepr.13286DOI Listing
January 2019
3 Reads

Serosal invasion is a strong prognostic factor for hepatocellular carcinoma after hepatectomy.

Hepatol Res 2018 Nov 7. Epub 2018 Nov 7.

Department of Surgery, Ehime University Hospital, Toon, Japan.

Aim: The clinical impact of serosal invasion by hepatocellular carcinoma (HCC) remains unclear. This study aimed to clarify the significance of serosal invasion as a prognostic factor for patients who underwent hepatectomy for HCC.

Methods: This retrospective study investigated patients who underwent hepatectomy for HCC between October 2003 and September 2016 in Ehime University Hospital (Toon, Japan). Read More

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http://doi.wiley.com/10.1111/hepr.13285
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http://dx.doi.org/10.1111/hepr.13285DOI Listing
November 2018
8 Reads

Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes.

Hepatol Res 2018 Oct 31. Epub 2018 Oct 31.

Institute of Biochemistry and Molecular Biology, Medical School of Ningbo University, Ningbo, China.

Aim: To measure the expression profile of circular RNA (circRNA) in hepatic tissues in a liver fibrosis model and to explore their function using molecular biology and bioinformatic techniques.

Methods: The classic CCl mouse liver fibrosis model was established alongside a normal control group. The circRNA expression profile of hepatic tissue from the two groups was compared using a high-throughput circRNA microarray. Read More

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http://dx.doi.org/10.1111/hepr.13284DOI Listing
October 2018
1 Read

Hepatitis C virus infection could affect the pathogenesis of ischemic heart diseases in northern Japan.

Hepatol Res 2018 Oct 30. Epub 2018 Oct 30.

Department of Hepatology, Sendai Kousei Hospital, Sendai, Japan.

Aims: Previously, our group reported that lymphotropic hepatitis C virus (HCV) could induce various kinds of immune dysfunctions. The immune dysfunctions could cause vascular disease by inducing cryoglobulinemia. It has been reported that ischemic heart diseases might be caused by HCV. Read More

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http://dx.doi.org/10.1111/hepr.13283DOI Listing
October 2018
3 Reads

Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non-alcoholic fatty liver disease.

Hepatol Res 2018 Oct 27. Epub 2018 Oct 27.

Liver Center, Saga University Hospital, Saga, Japan.

Aim: The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis-4 (FIB-4) index in a large general population cohort that underwent a health checkup.

Methods: A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non-alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB-4 index ≥1. Read More

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http://doi.wiley.com/10.1111/hepr.13282
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http://dx.doi.org/10.1111/hepr.13282DOI Listing
October 2018
3 Reads

Combining probiotics and an angiotensin-II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non-alcoholic steatohepatitis.

Hepatol Res 2018 Oct 26. Epub 2018 Oct 26.

Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan.

Aim: Intestinal endotoxin is important for the progression of non-alcoholic steatohepatitis (NASH). Circulating endotoxin levels are elevated in most animal models of diet-induced non-alcoholic fatty liver disease (NAFLD) and NASH. Furthermore, plasma endotoxin levels are significantly higher in NAFLD patients, which is associated with small intestinal bacterial overgrowth and increased intestinal permeability. Read More

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http://doi.wiley.com/10.1111/hepr.13281
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October 2018
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Relationship between various hepatic function scores and the formation of esophageal varices in patients with HIV/hepatitis C virus co-infection due to contaminated blood products for hemophilia.

Hepatol Res 2019 Feb 5;49(2):147-152. Epub 2018 Dec 5.

Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Aim: It is reportedly difficult to accurately assess the liver reserve capacity of patients with HIV/hepatitis C virus (HCV) co-infection through contaminated blood products by the Child-Pugh (CP) classification. Therefore, we investigated a clinically applicable scoring system in determining the risk of esophageal varices in HIV/HCV co-infected patients, known as latent portal hypertension leading to esophageal varices.

Methods: Forty-three patients with HIV/HCV co-infection underwent clinical examinations, including endoscopy and assessment of hepatic reserve, in our department between 2009 and 2017. Read More

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http://doi.wiley.com/10.1111/hepr.13279
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http://dx.doi.org/10.1111/hepr.13279DOI Listing
February 2019
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Proposed model for the prediction of intrahepatic covalently closed circular DNA level in patients with chronic hepatitis B.

Hepatol Res 2018 Oct 25. Epub 2018 Oct 25.

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

Aim: We sought to create a prediction model for intrahepatic covalently closed circular DNA (IH-cccDNA) level in chronic hepatitis B (CHB) patients and to validate the model's predictive accuracy.

Methods: Patients who did not receive previous nucleoside analogue (NA) therapy were assigned to the training cohort (n = 57), and those who received previous NA therapy were assigned to the validation cohort (n = 69). Factors linked to IH-cccDNA levels in the training cohort were analyzed and a formula to predict IH-cccDNA levels was constructed. Read More

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http://doi.wiley.com/10.1111/hepr.13280
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October 2018
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Hepatitis B virus (HBV)-infected patients with low hepatitis B surface antigen and high hepatitis B core-related antigen titers have a high risk of HBV-related hepatocellular carcinoma.

Hepatol Res 2019 Jan 27;49(1):51-63. Epub 2018 Dec 27.

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Chuo, Japan.

Aim: Although the viral markers hepatitis B surface antigen (HBsAg) and hepatitis B core-related antigen (HbcrAg) could reflect intrahepatic hepatitis B virus (HBV) replication activity and constitute important biomarkers for hepatocellular carcinoma (HCC), the value of using these two markers in combination for assessing HCC risk has not been clarified in detail.

Methods: Four hundred and forty-nine consecutive patients with chronic HBV infection were included in the study and the association of HBsAg and HBcrAg with HCC risk was investigated cross-sectionally, as well as longitudinally.

Results: When the high value cut-offs of HBsAg and HBcrAg were defined as 3. Read More

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http://doi.wiley.com/10.1111/hepr.13277
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January 2019
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Improved survival following splenectomy combined with curative treatments for hepatocellular carcinoma in Child B patients: A propensity score matching study.

Hepatol Res 2019 Feb 4;49(2):177-188. Epub 2019 Jan 4.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Aims: To explore the benefits of curative treatments (liver resection or local ablation) combined with splenectomy for patients with hepatocellular carcinoma (HCC) and Child grade B liver function.

Methods: We reviewed 245 patients with Child grade B liver function who underwent treatment with curative intent for HCC. Among these patients, 116 patients underwent curative treatment combined with splenectomy (the splenectomy group); the other 129 patients only underwent curative treatment (the non-splenectomy group). Read More

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http://doi.wiley.com/10.1111/hepr.13276
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February 2019
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Stevia prevents experimental cirrhosis by reducing hepatic myofibroblasts and modulating molecular profibrotic pathways.

Hepatol Res 2019 Feb 19;49(2):212-223. Epub 2018 Nov 19.

Laboratory of Experimental Hepatology, Department of Pharmacology, Cinvestav-IPN, Mexico City, Mexico.

Aim: The aims of the present study were to investigate the capacity of stevia leaves to prevent experimental cirrhosis induced by chronic administration of carbon tetrachloride (CCl ) in rats and to explore the action mechanism involved.

Methods: Liver cirrhosis was established by CCl treatment (400 mg/kg i.p. Read More

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February 2019
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Predictors of hepatocellular carcinoma occurrence after direct-acting antiviral therapy in patients with hepatitis C virus infection.

Hepatol Res 2019 Feb 20;49(2):136-146. Epub 2018 Nov 20.

Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Japan.

Aim: The predictors for the development of hepatocellular carcinoma (HCC) after direct-acting antiviral (DAA) treatment were investigated.

Methods: A total of 1174 patients with chronic hepatitis C virus infection were treated with DAA therapy (sofosbuvir and ledipasvir [n = 615], sofosbuvir and ribavirin [n = 380], and daclatasvir and asunaprevir [n = 179]) and achieved sustained virologic response (SVR). The HCC development rate and the factors that might contribute to the development of HCC after the end of DAA treatment were analyzed. Read More

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February 2019

Recent advances in medical management of hepatocellular carcinoma.

Authors:
Kenji Ikeda

Hepatol Res 2019 Jan 1;49(1):14-32. Epub 2018 Dec 1.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Transcatheter arterial therapies for hepatocellular carcinoma (HCC) have developed during the last decade. A fine powder formulation of cisplatin and the new platinum agent miriplatin became standard medicines in addition to anthracyclines in transcatheter arterial chemoembolization (TACE) in Japan. Recent prospective and retrospective studies supported the usefulness of platinum agents as a chemotherapeutic at the time of varied TACE therapy. Read More

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http://doi.wiley.com/10.1111/hepr.13259
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January 2019
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Efficacy of direct-acting antiviral treatment in patients with compensated liver cirrhosis: A multicenter study.

Hepatol Res 2019 Feb 13;49(2):125-135. Epub 2018 Nov 13.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Nippon Medical School, Tokyo, Japan.

Aim: Although the development of new direct-acting antivirals (DAAs) for the treatment of chronic hepatitis C virus (HCV) infection has markedly advanced, the effects of cirrhosis on DAA treatment remain unclear. We aimed to clarify the impact of cirrhosis on DAA treatment of patients infected with HCV.

Methods: This large-scale, multicenter, retrospective study consisted of 2130 HCV genotype 1b-infected patients who were treated with one of the following DAA combination therapies: asunaprevir/daclatasvir (ASV/DCV), ledipasvir/sofosbuvir (LDV/SOF), or paritaprevir/ombitasvir/ritonavir (PTV/OBV/r). Read More

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February 2019
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No-touch ablation in hepatocellular carcinoma has the potential to prevent intrasubsegmental recurrence to the same degree as surgical resection.

Hepatol Res 2019 Feb 6;49(2):164-176. Epub 2018 Nov 6.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Aim: The aim of this study was to clarify the utility of a no-touch pincer ablation procedure that uses bipolar electrodes to prevent intrasubsegmental tumor recurrence after radiofrequency ablation (RFA) for patients with hepatocellular carcinoma (HCC) compared to surgical resection.

Methods: We evaluated 175 consecutive patients with HCC (single nodule, tumor diameter ≤ 30 mm) who underwent surgical resection (146 received partial resection) and 313 patients who received RFA; 277 patients received touch ablation using a monopolar or bipolar RFA device, and 36 received no-touch ablation using a bipolar RFA device. Pretreatment arterial and portal phase dynamic computed tomography (CT) or magnetic resonance imaging (MRI) images were classified into four enhancement patterns: Type 1 and Type 2 are homogeneous enhancement patterns without or with increased arterial blood flow, respectively; Type 3 is a heterogeneous enhancement pattern with a septum-like structure; and Type 4 is an irregularly shaped ring structure enhancement pattern. Read More

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http://dx.doi.org/10.1111/hepr.13254DOI Listing
February 2019
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High recovery rate of consciousness by high-volume filtrate hemodiafiltration for fulminant hepatitis.

Hepatol Res 2019 Feb 9;49(2):224-231. Epub 2018 Nov 9.

Department of Emergency and Critical Care Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Aim: An artificial liver support (ALS) system sustaining patients with acute liver failure (ALF) in good condition until recovery of the native liver or performance of liver transplantation (LT), is essential for the improvement of the poor prognosis of ALF despite the lack of survival benefit. We aimed to investigate the efficacy of various ALS systems for fulminant hepatitis (FH) carried out in our liver unit so far, focusing on the restoration of consciousness from hepatic encephalopathy.

Methods: One hundred and ten consecutive adult Japanese patients with FH admitted to Chiba University Hospital (Chiba, Japan) between 1988 and 2016 who received ALS were analyzed. Read More

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February 2019
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Dysbalanced sex hormone status is an independent predictor of decompensation and mortality in patients with liver cirrhosis.

Hepatol Res 2019 Feb 31;49(2):201-211. Epub 2018 Oct 31.

Vienna Hepatic Hemodynamic Laboratory, Divison of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Aims: Endocrinological abnormalities, including low testosterone levels, are prevalent in cirrhosis. We assessed sexual hormone status in regard to hemodynamic abnormalities and its impact on hepatic decompensation and survival.

Methods: Males with cirrhosis were prospectively included in this study since 2010. Read More

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http://dx.doi.org/10.1111/hepr.13253DOI Listing
February 2019
2 Reads