2,997 results match your criteria Hepatology Research[Journal]


High Serum Interleukin-34 Level is a Predictor of Poor Prognosis in Patients with Non-viral Hepatocellular Carcinoma.

Hepatol Res 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastroenterology, Kurume University School of Medicine, Kurume, Japan.

Aims: We aimed to investigate the impact of interleukin (IL)-34 and YKL-40, regulators of hepatic fibrosis and tumor growth, on the prognosis of patients with non-viral hepatocellular carcinoma (HCC).

Methods: We enrolled 159 non-viral HCC patients (age, 70.8 ± 8. Read More

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http://dx.doi.org/10.1111/hepr.13350DOI Listing

Preformed donor-specific antibodies are associated with 90-day mortality in living-donor liver transplantation.

Hepatol Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Hepato-Biliary-Pancreatic and Breast Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, 791-0295, Japan.

Aim: The impact of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) on living donor liver transplantation (LDLT) is unclear. The aim of this study was to investigate the association between DSAs and short-term outcomes in LDLT recipients, and to clarify the clinical impact of DSAs.

Method: Anti-HLA antibodies were screened in pre-operative serum samples taken from 40 liver transplant recipients at Ehime University between August 2001 and July 2015. Read More

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http://dx.doi.org/10.1111/hepr.13352DOI Listing
April 2019
1 Read

Blocking development of liver fibrosis augments hepatic progenitor cell-derived liver regeneration in a mouse chronic liver injury model.

Hepatol Res 2019 Apr 16. Epub 2019 Apr 16.

Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan, 634-8522.

Background: The roles of hepatic progenitor cells (HPCs) in regeneration of a diseased liver are unclear. Hepatic stellate cells (HSC) contribute to liver fibrosis but are also a component of the HPC niche. HPCs expand along with HSC activation and liver fibrosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.13351
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http://dx.doi.org/10.1111/hepr.13351DOI Listing
April 2019
1 Read

Assessment of 10-year changes in liver stiffness using vibration-controlled transient elastography in nonalcoholic fatty liver disease.

Hepatol Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology and Hepatology, Yokohama City University Hospital, 3-9 Fukuura, Kanazawaku, Yokohama, 236-0033, Japan.

Background And Aim: Although a liver biopsy is golden standard for the diagnosis and staging of Nonalcoholic fatty liver disease (NAFLD), repeated assessment of patients' liver tissue conditions are impractical. We assessed the 10-year changes in liver stiffness measurements (LSM) utilizing vibration-controlled transient elastography (VCTE) in NAFLD patients.

Methods: From January 2006 to September 2007, LSM was performed for 97 biopsy-proven NAFLD patients. Read More

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http://dx.doi.org/10.1111/hepr.13349DOI Listing
April 2019
2 Reads

Branched-chain amino acids are associated with the heterogeneity of the area of lipid droplets in hepatocytes of patients with nonalcoholic fatty liver disease.

Hepatol Res 2019 Apr 10. Epub 2019 Apr 10.

Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aobaku, Sendai, 980-8574, Japan.

Aim: Macrovesicular steatosis around the central vein (zone 3) is one of the pathological features of non-alcoholic fatty liver disease, or steatohepatitis (NAFLD/NASH). The aim of this study is to elucidate precisely the association between the area of lipid droplets (LDs) and the plasma metabolic parameters in patients with NAFLD/NASH.

Methods: Eighty patients with NAFLD/NASH diagnosed by needle biopsy were enrolled. Read More

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http://dx.doi.org/10.1111/hepr.13346DOI Listing
April 2019
1 Read

Prognostic Impact of Transcatheter Arterial Chemoembolization (TACE) Combined with Radiofrequency Ablation in Patients with Unresectable Hepatocellular Carcinoma: A Comparison to TACE Alone using Decision-tree Analysis after Propensity Score Matching.

Hepatol Res 2019 Apr 10. Epub 2019 Apr 10.

Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan.

Aims: Prognosis of hepatocellular carcinoma (HCC) patients treated with transcatheter arterial chemoembolization (TACE) is still poor. We aimed to evaluate the impact of TACE combined with radiofrequency ablation (TACE+RFA) on the prognosis of HCC patients using decision-tree analysis after propensity score matching.

Methods: This was a retrospective study. Read More

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http://dx.doi.org/10.1111/hepr.13348DOI Listing

Emerging novel treatments for autoimmune liver diseases.

Authors:
Atsushi Tanaka

Hepatol Res 2019 Apr 10. Epub 2019 Apr 10.

School of Medicine, Teikyo University, Tokyo, Japan.

The etiology of autoimmune liver diseases, such as autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), still remains largely unknown and no therapeutic agents that are able to "cure" the disease have been developed. While corticosteroids for AIH and ursodeoxycholic acid (UDCA) for PBC have been shown to significantly improve liver transplantation (LT)-free survival and are recommended as first-line drugs, treatment strategies for patients who exhibit incomplete response to these drugs have not yet been fully established. No drug is significantly associated with long LT-free survival in PSC patients. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hepr.13347
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http://dx.doi.org/10.1111/hepr.13347DOI Listing
April 2019
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Deteriorated Outcome of Recent Patients with Acute Liver Failure and Late-Onset Hepatic Failure Caused by Infection with Hepatitis A Virus: A Subanalysis of Patients Seen Between 1998 and 2015 and Enrolled in Nationwide Surveys in Japan.

Hepatol Res 2019 Apr 7. Epub 2019 Apr 7.

Department of Gastroenterology & Hepatology, Saitama Medical University.

Aim: A nationwide survey of acute liver failure (ALF) and late-onset hepatic failure (LOHF) has revealed that the outcomes of recent patients whose diseases were caused by infection with hepatitis A virus (HAV) have worsened, compared with those of previously reported patients. Here, the factors associated with this deterioration were evaluated.

Methods: A total of 83 patients with HAV infection seen between 1998 and 2015 were enrolled. Read More

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http://dx.doi.org/10.1111/hepr.13345DOI Listing
April 2019
1 Read

Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics.

Hepatol Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Public Health, Jichi Medical University, Tochigi, Japan.

Aim: Idiopathic portal hypertension (IPH), extrahepatic portal obstruction (EHO), and Budd Chiari syndrome (BCS) are characterized by aberrant portal hemodynamics of unknown etiology. The aim of this study was to explore trends in the descriptive epidemiology of these diseases through periodical nationwide surveys.

Methods: Nationwide epidemiologic surveys were conducted in 1999, 2005, and 2015 using the same protocol. Read More

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http://dx.doi.org/10.1111/hepr.13343DOI Listing
April 2019
3 Reads

Long noncoding RNA miR143HG, low expression in hepatocellular carcinoma, predicts a good prognosis and inhibits tumor multiplication and metastasis by suppressing MAPK and Wnt signaling pathways.

Hepatol Res 2019 Apr 4. Epub 2019 Apr 4.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Background: The expression of miR143HG was significantly downregulated in hepatocellular carcinoma (HCC) tissues by bioinformatics analysis.

Materials And Methods: Fifty patients with HCC were divided into two groups based on the median miR143HG expression levels. The correlation between miR143HG expression and prognosis, and the correlations between miR143HG expression and the patients' clinicopathological characteristics were evaluated based on the two groups. Read More

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http://dx.doi.org/10.1111/hepr.13344DOI Listing
April 2019
2 Reads

An increase trend in the prevalence and male-to-female ratio of primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis in Japan.

Hepatol Res 2019 Apr 1. Epub 2019 Apr 1.

Faculty of Medical Technology, Teikyo University, Tokyo, Japan.

Background And Aim: Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) impose a significant burden on public health, and it is important to estimate prevalence of AILD. We conducted a nationwide, hospital-based, epidemiological survey of AIH, PBC, and PSC, and compared the results with those from previous surveys.

Method: We randomly selected healthcare facilities used in the survey from a list of all facilities in Japan. Read More

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http://dx.doi.org/10.1111/hepr.13342DOI Listing
April 2019
1 Read

A Case of Genotype-3b HCV in which Whole-genome was Successfully Analyzed Using Third-Generation Nanopore Sequencing.

Hepatol Res 2019 Mar 28. Epub 2019 Mar 28.

Department of Gastroenterology & Hepatology, Faculty of Medicine, Saitama Medical University, Iruma-Gun, Saitama, 350-0495, Japan.

A 42-year-old Chinese man with chronic HCV infection visited our hospital for antiviral therapy. The subgenotype could not be determined using the HCV GENOTYPE Primer Kit (Institute of Immunology Co., Ltd. Read More

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http://dx.doi.org/10.1111/hepr.13339DOI Listing

Circulating microRNA-1246 as a possible biomarker for early tumor recurrence of hepatocellular carcinoma.

Hepatol Res 2019 Mar 28. Epub 2019 Mar 28.

Gastroenterology and Hepatology, Hokkaido University Hospital, Sapporo, Japan.

Aims: Early tumor recurrence (ETR) after hepatic resection is a crucial predictor of poor prognosis in patients with hepatocellular carcinoma (HCC). The aim of this study was to identify clinically significant serum miRNAs involved in the ETR of HCC.

Methods: We compared expression profiles of circulating miRNAs from serum samples between 5 HCC patients with ETR (recurrence within 12 months after hepatectomy) and 5 HCC patients without recurrence using microarray analysis of miRNA. Read More

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http://dx.doi.org/10.1111/hepr.13338DOI Listing

Effect of Tolvaptan on the Prognosis in Patients with Hepatic Ascites.

Hepatol Res 2019 Mar 27. Epub 2019 Mar 27.

Digestive and Lifestyle Diseases, Department of Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Aim: Despite accumulating evidence concerning the efficacy of tolvaptan in the treatment of body fluid retention or hyponatremia, the effect of tolvaptan on the prognosis of patients with hepatic ascites has not been fully investigated.

Methods: A total of 628 patients with hepatic ascites who were treated with diuretics (furosemide, spironolactone, or tolvaptan) between 2007 and 2017 were enrolled and divided into two groups: one in which patients received tolvaptan (original tolvaptan group, n=278) and the other in which they did not (original control group, n=350). The cumulative survival rates between the groups were compared and the factors associated with survival in patients with hepatic ascites were identified using a Cox regression analysis. Read More

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http://dx.doi.org/10.1111/hepr.13337DOI Listing
March 2019
1 Read

Intra-procedural CT/MR-CEUS Fusion Imaging Improved Thermal Ablation Effect of Hepatocellular Carcinoma: Compared with Conventional Ultrasound.

Hepatol Res 2019 Mar 25. Epub 2019 Mar 25.

Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, Guangdong Province, PR China.

Aim: To retrospectively compare treatment effect of intra-procedural CT/MR-CEUS fusion imaging (FI) with that of conventional ultrasound (US) in the guidance and assessment of thermal ablation of hepatocellular carcinoma (HCC).

Methods: The FI group (112 patients with 129 HCC) was treated between April 2010 and December 2012, whereas the US group (83 patients with 90 HCC) was treated between January 2008 and March 2010. CT/MR-CEUS FI or US was used to guide puncture, provide immediate assessment and guide supplementary ablation, respectively. Read More

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http://dx.doi.org/10.1111/hepr.13336DOI Listing
March 2019
1 Read

Outcomes of conventional transarterial chemoembolization for hepatocellular carcinoma ≥10 cm.

Hepatol Res 2019 Mar 25. Epub 2019 Mar 25.

Internal Medicine, Fukui-ken Saiseikai Hospital, 7-1, Funabashi, Wadanaka-cho, Fukui, 918-8503, Japan.

Aim: To retrospectively evaluate the outcomes of conventional transarterial chemoembolization (cTACE) for hepatocellular carcinoma (HCC) ≥10 cm.

Methods: Twenty-five patients with naïve HCCs ≥10 cm (mean maximum tumor diameter, 130 ± 27.6 mm; single [n = 12], 2-9 [n = 6], and ≥10 [n = 7]) without extrahepatic spread treated with cTACE were eligible. Read More

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http://dx.doi.org/10.1111/hepr.13335DOI Listing
March 2019
1 Read

A Lille Model for Predicting the Response of Severe Alcoholic Hepatitis to Corticosteroid Treatment in Japanese Patients.

Hepatol Res 2019 Mar 22. Epub 2019 Mar 22.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, 020-8505, Japan.

Aim: Corticosteroids are the most widely used agents for the treatment of severe alcoholic hepatitis (SAH). The therapeutic effectiveness of corticosteroids is assessed by the Lille model, which has been validated well in Western countries; however, its usefulness has not yet been confirmed independently in Japanese patients. The present study aimed to determine whether the Lille model could predict the prognosis of SAH in Japanese patients. Read More

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http://dx.doi.org/10.1111/hepr.13334DOI Listing
March 2019
1 Read

Albumin-bilirubin score indicates liver fibrosis staging and prognosis in chronic hepatitis C patients.

Hepatol Res 2019 Mar 20. Epub 2019 Mar 20.

Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa, 761-0793, Japan.

Aim: Albumin-bilirubin (ALBI) grade was investigated to predict prognosis of patients with cirrhosis. It was defined using ALBI score calculated based on serum total bilirubin and albumin, which represent liver functions. The diagnostic accuracy for liver fibrosis staging in patients with chronic hepatitis using ALBI score has not been investigated well. Read More

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http://dx.doi.org/10.1111/hepr.13333DOI Listing
March 2019
2 Reads

Skeletal muscle volume loss during transarterial chemoembolization predicts poor prognosis in patients with hepatocellular carcinoma.

Hepatol Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Gastroenterology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Aim: Sarcopenia has a negative impact on the prognosis of patients with hepatocellular carcinoma (HCC). We investigated the significance of skeletal muscle volume and its changes in HCC patients receiving transarterial chemoembolization (TACE).

Methods: We retrospectively analyzed 179 HCC patients receiving TACE from 2006 to 2017. Read More

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http://dx.doi.org/10.1111/hepr.13331DOI Listing

Liver fibrosis markers as assessed by ultrasound elastography and serum samples: A large comparative study in hepatitis virus B and C liver diseases.

Hepatol Res 2019 Mar 18. Epub 2019 Mar 18.

Division of Hepatobiliary and Pancreatic disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Purposes: We aimed to compare the well-established liver fibrosis (LF) markers in Japanese patients with chronic hepatitis B (CHB, n=331) and chronic hepatitis C (CHC, n=886) and to discuss possible causes of differences in results between CHB patients and CHC patients.

Methods: Virtual touch quantification (VTQ) in acoustic radiation force impulse, Fib-4 index, aspartate aminotransferase to platelet ratio index (APRI) and hyaluronic acid (HA) were compared between the two cohorts. As an additional investigation, total collagen proportional area (TCPA, %) was tested using liver pathological samples (n=83). Read More

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http://dx.doi.org/10.1111/hepr.13332DOI Listing
March 2019
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Secondary sclerosing cholangitis with hemobilia induced by pembrolizumab: Case report and review of published work.

Hepatol Res 2019 Mar 12. Epub 2019 Mar 12.

Third Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

A 66-year-old man was admitted to our department due to cholestatic liver injury. He had received five cycles of pembrolizumab for small-cell lung cancer. Imaging showed the possibility of sclerosing cholangitis (SC) with hemobilia. Read More

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http://doi.wiley.com/10.1111/hepr.13329
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http://dx.doi.org/10.1111/hepr.13329DOI Listing
March 2019
9 Reads

Inhibition of microRNA-124a attenuates non-alcoholic fatty liver disease through upregulation of adipose triglyceride lipase and the effect of liraglutide intervention.

Hepatol Res 2019 Mar 12. Epub 2019 Mar 12.

NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin, China.

Aim: Glucagon-like peptide-1 receptor agonists (GLP-1Ras) have been reported to prevent non-alcoholic fatty liver disease (NAFLD), but the potential mechanisms are still debated. MicroRNAs (miRNAs) play a prominent role in the field of metabolic disorders, including NAFLD. Our study was designed to further evaluate the effect of GLP-1Ra liraglutide on NAFLD in terms of miRNAs. Read More

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http://dx.doi.org/10.1111/hepr.13330DOI Listing
March 2019
1 Read
2.218 Impact Factor

Albumin-Indocyanine Green Evaluation (ALICE) grade combined with portal hypertension to predict post-hepatectomy liver failure.

Hepatol Res 2019 Mar 8. Epub 2019 Mar 8.

Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Aim: The aim of this study was to evaluate the role of liver function factors in predicting a postoperative large-volume ascites (LA) and post-hepatectomy liver failure (PHLF).

Methods: We included 1025 consecutive patients undergoing hepatectomy for hepatocellular carcinoma between 2002 and 2014. Univariate and multivariate analyses were carried out to evaluate the role of each factor of liver function in predicting LA and PHLF. Read More

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http://dx.doi.org/10.1111/hepr.13327DOI Listing
March 2019
1 Read

Glecaprevir and pibrentasvir for Japanese patients with chronic hepatitis C genotype 1 or 2 infection: Results from a multicenter, real-world cohort study.

Hepatol Res 2019 Mar 8. Epub 2019 Mar 8.

Kyushu General Internal Medicine Center, Haradoi Hospital, Fukuoka, Japan.

Aim: Glecaprevir (GLE) and pibrentasvir (PIB) are new direct-acting antiviral agents (DAAs) with pangenotypic inhibitors that respectively target the hepatitis C virus (HCV) NS3/4 protease and NS5A. The aim of this study was to evaluate the effectiveness and safety of combining GLE and PIB for patients with HCV genotype (GT) 1 or 2 infection in the clinical setting, including patients DAA-experienced or on hemodialysis.

Methods: This multicenter, real-world, retrospective, cohort study consisted of 314 Japanese patients who were treated with GLE (300 mg) and PIB (120 mg) for a fixed 8- or 12-week duration. Read More

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http://dx.doi.org/10.1111/hepr.13328DOI Listing
March 2019
2 Reads

Host genetic factors and clinical parameters influencing the occult hepatitis C virus infection in patients on chronic hemodialysis: Is it still a controversial infection?

Hepatol Res 2019 Mar 1. Epub 2019 Mar 1.

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.

Aim: The presence of occult hepatitis C virus (HCV) infection (OCI) is still controversial, however, this infection cannot be ignored. Therefore, the current study aimed at assessing the OCI frequency in patients on chronic hemodialysis (CHD) and also evaluating the association between OCI incidence with clinical parameters and interferon lambda 3/4 (IFNL3/4) gene polymorphisms.

Methods: A total of 515 patients on CHD and HCV negative markers were selected. Read More

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http://dx.doi.org/10.1111/hepr.13325DOI Listing

Hepatic gene expression in mouse models of non-alcoholic fatty liver disease after acute exercise.

Hepatol Res 2019 Feb 27. Epub 2019 Feb 27.

Hepatology, Department for BioMedical Research, University of Bern, Bern, Switzerland.

Aim: Non-alcoholic fatty liver disease (NAFLD) patients benefit from physical exercise. This study aimed to investigate the effect of acute exercise on hepatic gene expression in different mouse models of NAFLD.

Methods: C57BL/6J mice were fed with a control (CD) or a high fat (HFD) diet. Read More

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http://dx.doi.org/10.1111/hepr.13323DOI Listing
February 2019
2 Reads

Correlation between hepatic oxidative damage and clinical severity and mitochondrial gene sequencing results in biliary atresia.

Hepatol Res 2019 Feb 27. Epub 2019 Feb 27.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.

Aim: To assess the level of hepatic oxidative damage and its correlation with clinical severity in biliary atresia (BA), and to understand BA mitochondrial gene sequencing.

Methods: Forty-eight BA patients and 28 control subjects (20 hepatoblastoma and 8 cholestasis patients) were enrolled. Hepatic oxidative damage was assessed by the expression of oxidation and antioxidant genes, and the correlation between oxidative damage and BA incidence, liver inflammation, and fibrosis was evaluated. Read More

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http://dx.doi.org/10.1111/hepr.13324DOI Listing
February 2019
3 Reads

Prediction of risk of falls based on handgrip strength in chronic liver disease patients living independently.

Hepatol Res 2019 Feb 16. Epub 2019 Feb 16.

Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.

Aim: Falling is known to be associated with cognitive function. We evaluated the relationship between muscle function and falls in patients with chronic liver disease (CLD).

Methods: We enrolled 100 sequential CLD patients without dementia who were admitted to our institution for scheduled treatment from July 2017 to May 2018 (age 71. Read More

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http://dx.doi.org/10.1111/hepr.13322DOI Listing
February 2019
1 Read

Clinical and pathological features of sarcopenia-related indices in patients with non-alcoholic fatty liver disease.

Hepatol Res 2019 Feb 4. Epub 2019 Feb 4.

Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto.

Background: Sarcopenia is diagnosed with the skeletal muscle index (SMI) or the sarcopenia index (SI). We previously reported that the ratio of skeletal muscle mass to body fat mass (SF ratio) was a novel index of sarcopenia in patients with non-alcoholic fatty liver disease (NAFLD). The aim of this retrospective study was to evaluate sarcopenia with these indices in patients with NAFLD. Read More

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http://dx.doi.org/10.1111/hepr.13321DOI Listing
February 2019
3 Reads

Risk-benefit point of the Model for End-stage Liver Disease score in patients waiting for deceased-donor liver transplantation: A single-center experience.

Hepatol Res 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Aim: To clarify the risk-benefit point of the Model for End-stage Liver Disease (MELD) score in patients waiting for deceased-donor liver transplantation (DDLT).

Methods: The present study retrospectively investigated 213 patients registered on the waiting list at Kyoto University (Kyoto, Japan) between 2005 and 2016. Patients were stratified by MELD score (6-9/10-14/15-20/21-30/31-40) and classified into two groups: the DDLT group (30 patients) and the waiting group (183 patients). Read More

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http://dx.doi.org/10.1111/hepr.13320DOI Listing
January 2019

CD4 T cells from patients with primary biliary cholangitis show T cell activation and differentially expressed T-cell receptor repertoires.

Hepatol Res 2019 Jan 28. Epub 2019 Jan 28.

Division of Advanced Genome Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Aim: Primary biliary cholangitis (PBC) is an autoimmune liver disease with unknown pathogenesis. In PBC, activation of T-cell receptor (TCR) signaling is associated with inflammatory cytokine production through N-Ras upregulation. Although the CD4 T cell TCR repertoire could be associated with PBC pathogenesis, it has not been evaluated. Read More

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http://dx.doi.org/10.1111/hepr.13318DOI Listing
January 2019
2 Reads

Comparison of liver stiffness assessment by transient elastography and shear wave elastography using six ultrasound devices.

Hepatol Res 2019 Jan 24. Epub 2019 Jan 24.

Division of Hepatobiliary and Pancreatic Disease, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.

Aim: Transient elastography (TE) is the gold standard for measurement of liver stiffness. The usefulness of shear wave elastographies (SWE) is well accepted. However, the measurement values cannot be equivalently compared because cut-off values for the diagnosis of liver fibrosis are different among those devices. Read More

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http://doi.wiley.com/10.1111/hepr.13319
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http://dx.doi.org/10.1111/hepr.13319DOI Listing
January 2019
8 Reads

Vitamin A-coupled liposomal Rho-kinase inhibitor ameliorates liver fibrosis without systemic adverse effects.

Hepatol Res 2019 Jan 23. Epub 2019 Jan 23.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Aim: Rho-kinase (ROCK) inhibitor could ameliorate liver fibrosis by suppressing hepatic stellate cell (HSC) activation. However, because systemic administration of ROCK inhibitor causes serious adverse effects, we developed a drug delivery system selectively delivering ROCK inhibitor to HSCs. Here, we examined whether our developed vitamin A (VA)-coupled liposomal ROCK inhibitor reduced liver fibrosis in rats without causing systemic adverse effects. Read More

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http://dx.doi.org/10.1111/hepr.13317DOI Listing
January 2019

Protective effects of gastrin-releasing peptide receptor antagonist RC-3095 in an animal model of hepatic ischemia/reperfusion injury.

Hepatol Res 2019 Mar 7;49(3):247-255. Epub 2019 Feb 7.

Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Aim: We aimed to evaluate effects of RC-3095 on mice with hepatic ischemia followed by reperfusion (I/R) injury and further explore the possible underlying mechanism.

Methods: Mice were subjected to partial hepatic ischemia for 60 min followed by different durations of reperfusion. Levels of gastrin-releasing peptide (GRP) and GRP receptor (GRPR) in the blood and liver were detected by enzyme-linked immunosorbent assay (ELISA) or western blotting (WB) after 3, 6, 12, or 24 h of reperfusion. Read More

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http://dx.doi.org/10.1111/hepr.13315DOI Listing
March 2019
2 Reads

Outbreak of hepatitis A linked to European outbreaks among men who have sex with men in Osaka, Japan, from March to July 2018.

Hepatol Res 2019 Jan 17. Epub 2019 Jan 17.

Department of Gastroenterology and Hepatology, National Hospital Organization Osaka National Hospital, Osaka, Japan.

Aim: Ongoing hepatitis A outbreaks among men who have sex with men (MSM) have been reported worldwide, mainly in Europe, since 2016. In Japan, there has been an increase in the number of notified hepatitis A cases since January 2018, most of which were suspected to have been transmitted through homosexual contact. In this paper, we describe the current outbreak situation of hepatitis A among MSM. Read More

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http://dx.doi.org/10.1111/hepr.13314DOI Listing
January 2019
4 Reads

Full-genome characterization of the RIVM-HAV16-090-like hepatitis A virus strains recovered from Japanese men who have sex with men, with sporadic acute hepatitis A.

Hepatol Res 2019 Jan 15. Epub 2019 Jan 15.

Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.

Aim: The major transmission mode of hepatitis A virus (HAV) in Japan is the fecal-oral route by contaminated foods. In contrast, HAV infection is well documented as a sexually transmitted disease in Europe and North America. The present study was undertaken to determine the full-genome sequence of HAV and trace the transmission route of HAV in Japanese men who have sex with men (MSM). Read More

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http://dx.doi.org/10.1111/hepr.13313DOI Listing
January 2019
4 Reads

Utility of ultrasound-guided liver tumor biopsy for next-generation sequencing-based clinical sequencing.

Hepatol Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Aim: Recent advances in next-generation sequencing (NGS) technologies allow for evaluation of genetic alterations in various cancer-related genes in daily clinical practice. Archival formalin-fixed paraffin-embedded (FFPE) tumor tissue is often used for NGS-based clinical sequencing assays; however, the success rate of NGS assays using archival FFPE tumor tissue is reported to be lower than that using fresh tumor tissue. We aimed to evaluate the feasibility and safety of ultrasound (US)-guided liver tumor biopsy for NGS-based multiplex gene assays. Read More

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http://dx.doi.org/10.1111/hepr.13312DOI Listing
January 2019
3 Reads

Influence of renal dysfunction on dose reduction and virologic efficacy of regimens combining ribavirin and all-oral direct acting antivirals in patients with chronic hepatitis C virus infection.

Hepatol Res 2019 Jan 10. Epub 2019 Jan 10.

Department of Nursing, Ogaki Women's College, Ogaki, Japan.

Aim: Several interferon (IFN)-free, all-oral regimens with direct acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection also include ribavirin (RBV). We investigated the influence of renal dysfunction on virologic efficacy and adverse effects in 189 patients with HCV genotype 2 infection who received combination RBV-DAA regimens.

Methods: The incidence of RBV-induced anemia, RBV dose reduction, and virologic efficacy were compared according to baseline renal function as defined by the estimated glomerular filtration rate (eGFR). Read More

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http://dx.doi.org/10.1111/hepr.13311DOI Listing
January 2019
4 Reads

Risk factors for loss of skeletal muscle mass in patients with cirrhosis.

Hepatol Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Aim: The present study aimed to assess the correlation between loss of skeletal muscle mass (LSMM) and the clinical characteristics of patients with liver cirrhosis.

Methods: This multicenter, prospective study was undertaken at five locations in Japan and involved a 12-month observation period. After baseline assessment, the change in the skeletal muscle index per year (ΔSMI/y) was evaluated in the enrolled patients; LSMM was defined as ΔSMI/y < 0. Read More

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http://dx.doi.org/10.1111/hepr.13308DOI Listing
January 2019
3 Reads

Oncogenic role of phospholipase C-γ1 in progression of hepatocellular carcinoma.

Hepatol Res 2019 Jan 8. Epub 2019 Jan 8.

Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Aim: Phospholipase C-γ1 (PLCG1) was previously found to be involved in a variety of oncogenic behaviors such as cell motility, cell proliferation, cell migration, and invasion. However, its function in hepatocellular carcinoma (HCC) was unknown. Here, we explored the expression pattern and function of PLCG1 in HCC progression. Read More

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http://doi.wiley.com/10.1111/hepr.13309
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http://dx.doi.org/10.1111/hepr.13309DOI Listing
January 2019
13 Reads

Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response.

Hepatol Res 2019 Jan 8. Epub 2019 Jan 8.

Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita.

Aim: In patients with chronic hepatitis C, hepatocellular carcinoma (HCC) occurs at a certain frequency, even if a sustained virologic response (SVR) is achieved by antiviral treatment. Old age, liver fibrosis, and high post-treatment α-fetoprotein (AFP) level are typical risk factors of post-SVR HCC. We examined whether the frequencies and factors of HCC in patients with an SVR achieved from interferon treatment changed. Read More

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http://doi.wiley.com/10.1111/hepr.13310
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http://dx.doi.org/10.1111/hepr.13310DOI Listing
January 2019
11 Reads

Association of serum interferon-λ3 levels with hepatocarcinogenesis in chronic hepatitis C patients treated with direct-acting antiviral agents.

Hepatol Res 2019 Jan 9. Epub 2019 Jan 9.

Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.

Aim: Although the efficacy of hepatitis C virus (HCV) treatment is improved dramatically by direct-acting antiviral agents (DAAs), the assessment of hepatocellular carcinoma (HCC) remains important. Interferon lambda 3 (IFN-λ3) is associated with liver fibrosis and inflammation in chronic hepatitis C (CHC) patients, but its impact on carcinogenesis remains controversial and little is known about its effects after viral clearance. To determine the contribution of IFN-λ3 to hepatocarcinogenesis after HCV clearance, we analyzed IFNL3 genotypes and serial serum IFN-λ3 levels in CHC patients who achieved sustained virologic responses (SVR). Read More

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http://dx.doi.org/10.1111/hepr.13307DOI Listing
January 2019
5 Reads

Efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation in patients with recurrent hepatocellular carcinoma and thrombocytopenia.

Hepatol Res 2019 Jan 2. Epub 2019 Jan 2.

Department of Gastroenterology and Hepatology, Saiseikai Niigata Daini Hospital, Niigata, Japan.

Aims: Thrombocytopenia is often associated with chronic liver disease. Lusutrombopag is a small molecule thrombopoietin receptor agonist designed to temporarily increase the platelet count in patients with chronic liver disease for whom elective invasive procedures are planned. In the present study, the efficacy and safety of repeated use of lusutrombopag prior to radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma were examined. Read More

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http://dx.doi.org/10.1111/hepr.13305DOI Listing
January 2019
1 Read

Portal hypertension in hepatitis B-related cirrhosis: Diagnostic accuracy of liver and spleen stiffness by 2-D shear-wave elastography.

Hepatol Res 2018 Dec 29. Epub 2018 Dec 29.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

Aim: To assess the diagnostic accuracy of liver and spleen stiffness measured by 2-D shear-wave elastography (SWE) in evaluation of clinically significant and severe portal hypertension (CSPH and SPH, respectively).

Methods: Clinical data of 155 hepatitis B-related cirrhosis patients and their liver and spleen stiffness (L-SWE and S-SWE, respectively) were collected. The diagnostic performances of L-SWE, S-SWE, the liver stiffness-spleen diameter to platelet ratio score (LSPS) and portal hypertension risk score were evaluated. Read More

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http://dx.doi.org/10.1111/hepr.13306DOI Listing
December 2018
5 Reads

Rifaximin-altered gut microbiota components associated with liver/neuropsychological functions in patients with hepatic encephalopathy: An exploratory data analysis of phase II/III clinical trials.

Hepatol Res 2019 Apr 1;49(4):404-418. Epub 2019 Feb 1.

Division of Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.

Aims: Rifaximin (RFX), a non-systemic antibiotic, improves liver/neuropsychological functions in patients with hepatic encephalopathy (HE). We aimed to investigate the clinical profiles associated with gut bacterial loads using exploratory data analysis and the effects of RFX on the gut microbiota of patients with HE.

Methods: We analyzed the data from 17 patients with HE who underwent fecal microbiota examination in phase II/III trials in Japan. Read More

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http://doi.wiley.com/10.1111/hepr.13300
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http://dx.doi.org/10.1111/hepr.13300DOI Listing
April 2019
4 Reads

Impact of sodium glucose cotransporter 2 inhibitor on histological features and glucose metabolism of non-alcoholic fatty liver disease complicated by diabetes mellitus.

Hepatol Res 2018 Dec 21. Epub 2018 Dec 21.

Department of Hepatology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo, Japan.

Aim: The aim of this study was to investigate the therapeutic potential of sodium glucose cotransporter 2 inhibitor (SGLT2I) as an effective therapeutic option for non-alcoholic fatty liver disease (NAFLD).

Methods: In this prospective study, nine patients with NAFLD complicated by type 2 diabetes mellitus (DM), were introduced to the regimen of canagliflozin 100 mg once daily for 24 weeks and were evaluated by liver histology at pretreatment and at 24 weeks after the start of treatment. The primary outcome was histological improvement, defined as a decrease in NAFLD activity score of one point or more without worsening in fibrosis stage. Read More

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http://doi.wiley.com/10.1111/hepr.13304
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http://dx.doi.org/10.1111/hepr.13304DOI Listing
December 2018
31 Reads

Acute liver failure due to severe Herpes simplex viral hepatitis in an elderly woman: A case of initial infection.

Hepatol Res 2018 Dec 21. Epub 2018 Dec 21.

Department of Gastroenterology, Saiseikai Kanazawa Hospital, Kanazawa.

The high mortality rate due to severe Herpes simplex viral (HSV) hepatitis is associated with the difficulty of its diagnosis. We describe the extremely rapid disease course of a patient who died of severe HSV hepatitis. A 73-year-old woman was admitted for a bronchial asthma attack. Read More

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http://doi.wiley.com/10.1111/hepr.13301
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http://dx.doi.org/10.1111/hepr.13301DOI Listing
December 2018
29 Reads
2.218 Impact Factor

Rescue therapy for chronic hepatitis C virus infection after repeated treatment failures: Impact on disease progression and risk of hepatocellular carcinoma.

Hepatol Res 2019 Apr 28;49(4):377-384. Epub 2019 Jan 28.

Department of Tropical Medicine, Tanta University, Tanta, Egypt.

Aim: Retreatment after previous failure of direct-acting antivirals for hepatitis C virus (HCV) infection is a challenging decision. The importance of achieving viral eradication on modification of disease progression and outcome, including the risk of hepatocellular carcinoma (HCC), remains a critical issue to be evaluated.

Methods: One hundred patients with repeated failure of sofosbuvir and ribavirin or triple therapy with sofosbuvir, ribavirin, and daclatasvir were divided into a study group (n = 50) given rescue therapy (sofosbuvir, daclatasvir, simeprevir, and ribavirin) or a control group (n = 50) matched for age, sex, and pretreatment variables (Child-Turcotte-Pugh score and Fibrosis-4 score). Read More

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http://dx.doi.org/10.1111/hepr.13303DOI Listing
April 2019
2 Reads
2.218 Impact Factor

Ischemic complications after percutaneous radiofrequency ablation of liver tumors: Liver volume loss and recovery.

Hepatol Res 2019 Apr 6;49(4):453-461. Epub 2019 Feb 6.

Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Aim: The liver regrows after acute liver injury and liver resection. However, it is not clear whether the liver regenerates in advanced cirrhosis. This study aimed to evaluate the clinical course of, and liver volume change after, ischemic liver complications caused by radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1111/hepr.13302DOI Listing
April 2019
2 Reads

Analysis of 307 cases with drug-induced liver injury between 2010 and 2018 in Japan.

Hepatol Res 2019 Jan;49(1):105-110

Department of Gastroenterology and Hepatology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.

Aim: In order to know the present status of drug-induced liver injury (DILI) in Japan, we present the data of prospectively collected DILI cases between 2010 and 2018 from 27 hospitals.

Methods: Drug-induced liver injury cases diagnosed by DILI experts from 27 hospitals all over Japan have been prospectively collected since 2010. Alanine aminotransferase level ≥150 U/L and/or alkaline phosphatase ≥2× upper limit of normal were inclusion criteria. Read More

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http://doi.wiley.com/10.1111/hepr.13288
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http://dx.doi.org/10.1111/hepr.13288DOI Listing
January 2019
16 Reads
2.218 Impact Factor