16,072 results match your criteria Hepatocellular Carcinoma Imaging


Contrast-Enhanced Ultrasound Algorithms (CEUS-LIRADS/ESCULAP) for the Noninvasive Diagnosis of Hepatocellular Carcinoma - A Prospective Multicenter DEGUM Study.

Ultraschall Med 2020 Jul 14. Epub 2020 Jul 14.

Department of Internal Medicine 1, University Hospital Erlangen, Germany.

Background:  This prospective multicenter study funded by the DEGUM assesses the diagnostic accuracy of standardized contrast-enhanced ultrasound (CEUS) for the noninvasive diagnosis of hepatocellular carcinoma (HCC) in high-risk patients.

Methods:  Patients at high risk for HCC with a histologically proven focal liver lesion on B-mode ultrasound were recruited prospectively in a multicenter approach. Clinical and imaging data were entered via online entry forms. Read More

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http://dx.doi.org/10.1055/a-1198-4874DOI Listing

Hepatocellular carcinoma with ring calcification mimicking hydatid disease: a case report.

Surg Case Rep 2020 Jul 13;6(1):171. Epub 2020 Jul 13.

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1Kawada-cho, Shinjuku-ku, Tokyo, Japan.

Background: Ring calcification in hepatocellular carcinoma is extremely rare. Untreated hepatocellular carcinoma occasionally includes calcified lesions. Here, we report a case of ring-calcified hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1186/s40792-020-00927-5DOI Listing

Manual versus automated image fusion of real-time ultrasonography and MR/CT images for radiofrequency ablation of hepatic tumors: Results of a randomized prospective trial.

Ultrasonography 2020 May 21. Epub 2020 May 21.

Department of Radiology, Eunpyeong St.Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea.

Purpose: To compare the technical parameters of imaging fusion and clinical outcomes of manual and automatic image fusion techniques of ultrasonography and MRI/CT for radiofrequency ablation (RFA) of hepatic tumors.

Methods: Seventy consecutive patients (M:F=47:23, 67.1±10. Read More

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http://dx.doi.org/10.14366/usg.20052DOI Listing

[Quantitative evaluation of early stage blood flow change status after radiofrequency ablation based on multi-slice spiral CT whole-liver perfusion imaging on small hepatocellular carcinoma].

Zhonghua Gan Zang Bing Za Zhi 2020 Jun;28(6):488-493

Department of Interventional Radiology, General Hospital of Ningxia Medical University, Yinchuan 750001, China.

To investigate the blood flow change status in early stage tumor-related areas of hepatocellular carcinoma and its clinical significance after radiofrequency ablation using multi-slice spiral CT whole-liver perfusion imaging technology. 21 cases of primary liver cancer that underwent CT-guided radiofrequency ablation were included. CT perfusion scans were divided into four groups according to the time points of CT scans (before surgery, immediately after surgery and 1 and 3 month after surgery), and then blood perfusion parameters of the corresponding areas of the tumor were measured. Read More

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http://dx.doi.org/10.3760/cma.j.cn501113-20200317-00120DOI Listing

Comparison of radiofrequency and microwave ablation and identification of risk factors for primary treatment failure and local progression.

Clin Imaging 2020 Jun 20;67:146-151. Epub 2020 Jun 20.

Department of Radiology, UT Southwestern Medical Center, United States of America; Department of Radiology, Massachusetts General Hospital, United States of America.

Purpose: To compare percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for treatment of Hepatocellular carcinoma (HCC) and to identify risk factors for treatment failure and local progression.

Methods: 145 unique HCC [87 (60%) RFA, 58 (40%) MWA] were retrospectively reviewed from a single tertiary medical center. Adverse events were classified as severe, moderate, or mild according to the Society of Interventional Radiology Adverse Event Classification system. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.014DOI Listing

Predictors, Presentation, and Treatment Outcomes of Recurrent Hepatocellular Carcinoma After Liver Transplantation: A Large Single Center Experience.

J Clin Exp Hepatol 2020 Jul-Aug;10(4):304-315. Epub 2019 Nov 22.

Department of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA.

Background: Liver transplantation (LT) is an accepted therapeutic option for hepatocellular carcinoma (HCC) in patients with cirrhosis. Despite careful candidate selection, HCC recurrence occurs. We aimed to describe the predictors of recurrence, clinical presentation, and predictors of survival after HCC recurrence post-LT. Read More

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http://dx.doi.org/10.1016/j.jceh.2019.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335705PMC
November 2019

Surveillance and Monitoring of Hepatocellular Carcinoma During the COVID-19 Pandemic.

Clin Gastroenterol Hepatol 2020 Jul 8. Epub 2020 Jul 8.

Division of Digestive and Liver Disease, UT Southwestern Medical Center.

The Coronavirus disease 2019 (COVID-19) pandemic is expected to have a long-lasting impact on the approach to care for patients at risk for and with hepatocellular carcinoma (HCC) due to the risks from potential exposure and resource reallocation. The goal of this document is to provide recommendations on HCC surveillance and monitoring, including strategies to limit unnecessary exposure while continuing to provide high-quality care for patients. Publications and guidelines pertaining to the management of HCC during COVID-19 were reviewed for recommendations related to surveillance and monitoring practices, and any available guidance was referenced to support the authors' recommendations when applicable. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.06.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342037PMC

Total skeletal, psoas and rectus abdominis muscle mass as prognostic factors for patients with advanced hepatocellular carcinoma.

J Formos Med Assoc 2020 Jul 7. Epub 2020 Jul 7.

Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Purpose: We investigated whether low skeletal muscle mass (LSMM) defined according to different muscle groups on computed tomography (CT) scans are predictive factors of survival for advanced hepatocellular carcinoma (HCC).

Methods: In this retrospective study, we analyzed patients who received sorafenib therapy for advanced HCC in a prospective patient cohort between 2007 and 2012. The total skeletal muscle (TSM), paraspinal muscle (PS), psoas muscle (PM), rectus abdominis (RA), and abdominal wall (AW) muscle areas were evaluated using a single CT slice at the third lumbar vertebra before treatment. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.07.005DOI Listing

Large surgically resected leiomyosarcoma of the liver: a case report.

Surg Case Rep 2020 Jul 9;6(1):168. Epub 2020 Jul 9.

Department of Surgery, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, 1-9-6 Senda-machi, Naka-ku, Hiroshima 730-8619, Japan.

Background: Primary hepatic leiomyosarcoma (PHL) is an extremely rare type of tumor. We herein report a case of a large surgically resected leiomyosarcoma of the liver.

Case Presentation: A 69-year-old man with a feeling of epigastric compression was referred for examination of an abdominal mass. Read More

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http://dx.doi.org/10.1186/s40792-020-00934-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347740PMC

How to Best Detect Portal Vein Tumor Thrombosis in Patients with Hepatocellular Carcinoma Meeting the Milan Criteria: Gadoxetic Acid-Enhanced MRI versus Contrast-Enhanced CT.

Liver Cancer 2020 Jun 28;9(3):293-307. Epub 2020 Jan 28.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Introduction: The detection of portal vein tumor thrombosis (PVTT) in patients with hepatocellular carcinoma (HCC) meeting the Milan criteria is of critical importance as PVTT is known to be a contraindication to transplantation and an indicator of a dismal prognosis.

Objective: To determine which modality may best detect PVTT, we compared the diagnostic performance of gadoxetic acid-enhanced MRI (GA-MRI) and contrast-enhanced CT (CECT) in HCC patients meeting the Milan criteria.

Methods: We retrospectively enrolled 310 patients with HCCs meeting the Milan criteria who underwent both GA-MRI and CECT between June 2007 and May 2017. Read More

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http://dx.doi.org/10.1159/000505191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325130PMC

Pretreatment Heterogeneous Enhancement Pattern of Hepatocellular Carcinoma May Be a Useful New Predictor of Early Response to Lenvatinib and Overall Prognosis.

Liver Cancer 2020 Jun 4;9(3):275-292. Epub 2020 Feb 4.

Department of Hepatology, Toranomon Hospital, Tokyo, Japan.

Objective: The aim of this study was to evaluate the performance of pretreatment computed tomography (CT) enhancement of hepatocellular carcinoma (HCC) as a potential predictor of response to lenvatinib and its relevance to survival outcomes.

Methods: We evaluated 51 consecutive patients who received lenvatinib treatment for unresectable HCC. On imaging analysis, pretreatment arterial/portal phase dynamic CT images were classified as follows: type 2, homogeneous enhancement pattern with increased arterial blood flow; type 3, heterogeneous enhancement pattern with a septum-like structure; and type 4, heterogeneous enhancement pattern with irregularly shaped ring structures. Read More

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http://dx.doi.org/10.1159/000505190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325131PMC

Direct-Acting Antiviral Agents Reduce the Risk of Malignant Transformation of Hepatobiliary Phase-Hypointense Nodule without Arterial Phase Hyperenhancement to Hepatocellular Carcinoma on Gd-EOB-DPTA-Enhanced Imaging in the Hepatitis C Virus-Infected Liver.

Liver Cancer 2020 Jun 7;9(3):261-274. Epub 2020 Jan 7.

Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.

Background And Aims: Hepatobiliary phase-hypointense nodules without arterial phase hyperenhancement (HHNs without APHE) on gadolinium-ethoxybenzyl-diethylenetriamine-enhanced magnetic resonance imaging (Gd-EOB-DTPA-enhanced MRI) are considered to be dysplastic nodules or early hepatocellular carcinoma (HCC) and have high risk of undergoing malignant transformation and progression to hypervascular HCC. The aim of this study was to evaluate the clinical outcome of HHNs without APHE diagnosed by Gd-EOB-DTPA-enhanced MRI before the eradication of HCV by direct-acting antiviral agents (DAAs).

Methods: We retrospectively investigated 221 consecutive patients with HCV infection who were treated with DAAs. Read More

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http://dx.doi.org/10.1159/000504889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325122PMC

Contrast-Enhanced Ultrasound Liver Imaging Reporting and Data System in Diagnosing Hepatocellular Carcinoma: Diagnostic Performance and Interobserver Agreement.

Ultraschall Med 2020 Jul 8. Epub 2020 Jul 8.

Department of Ultrasound, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Objectives:  To determine the diagnostic performance and inter-reader agreement of the contrast-enhanced ultrasound liver imaging reporting and data system (CEUS-LI-RADS) for diagnosing hepatocellular carcinoma (HCC) in high-risk patients.

Methods:  In this prospective study, CEUS-LI-RADS categories (LR-5 for predicting HCC) were assigned by six blinded readers and compared to the definitive HCC diagnosis in patients with liver cirrhosis per the 2017 China Liver Cancer Guidelines (CLCG). CEUS features were recorded in 96 patients with 96 histology-proven lesions. Read More

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http://dx.doi.org/10.1055/a-1168-6321DOI Listing

Iterative reconstruction algorithm improves the image quality without affecting quantitative measurements of computed tomography perfusion in the upper abdomen.

Eur J Radiol Open 2020 3;7:100243. Epub 2020 Jul 3.

Department of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Objective: To investigate differences between reconstruction algorithms in quantitative perfusion values and time-attenuation curves in computed tomography perfusion (CTP) examinations of the upper abdomen.

Methods: Twenty-six CTP examinations were reconstructed with filtered back projection and an iterative reconstruction algorithm, advanced modeled iterative reconstruction (ADMIRE), with different levels of noise-reduction strength. Using the maximum-slope model, quantitative measurements were obtained: blood flow (mL/min/100 mL), blood volume (mL/100 mL), time to peak (s), arterial liver perfusion (mL/100 mL/min), portal venous liver perfusion (mL/100 mL/min), hepatic perfusion index (%), temporal maximum intensity projection (Hounsfield units (HU)) and temporal average HU. Read More

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http://dx.doi.org/10.1016/j.ejro.2020.100243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334814PMC

Risk of Liver Cirrhosis and Hepatocellular Carcinoma after Fontan Operation: A Need for Surveillance.

Cancers (Basel) 2020 Jul 6;12(7). Epub 2020 Jul 6.

Division of Pediatric Cardiology, Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.

Liver cirrhosis and hepatocellular carcinoma (HCC) are serious late complications that can occur after the Fontan procedure. This study aimed to investigate the cumulative incidence of cirrhosis and HCC and to identify specific features distinguishing HCC from benign arterial-phase hyperenhancing (APHE) nodules that developed after the Fontan operation. We retrospectively enrolled 313 post-Fontan patients who had been followed for more than 5 years and had undergone ultrasound or computed tomography (CT) of the liver between January 2000 and August 2018. Read More

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http://dx.doi.org/10.3390/cancers12071805DOI Listing

CT and MRI Liver Imaging Reporting and Data System Version 2018 for Hepatocellular Carcinoma: A Systematic Review With Meta-Analysis.

J Am Coll Radiol 2020 Jul 5. Epub 2020 Jul 5.

Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The aim of this study was to determine the diagnostic performance of the LR-5 category for hepatocellular carcinoma (HCC) and the pooled proportion of HCC in each Liver Imaging Reporting and Data System (LI-RADS™) category with CT and MRI, using LI-RADS version 2018.

Methods: The MEDLINE, Embase, and Scopus databases were searched from inception to December 7, 2019, for studies reporting the diagnostic accuracy of LI-RADS version 2018 for HCC. Risk for bias and concerns regarding applicability were assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Read More

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http://dx.doi.org/10.1016/j.jacr.2020.06.005DOI Listing

Consensus recommendations of three-dimensional visualization for diagnosis and management of liver diseases.

Hepatol Int 2020 Jul 7. Epub 2020 Jul 7.

CHESS Center, Institute of Portal Hypertension, The First Hospital of Lanzhou University, Lanzhou, China.

Three-dimensional (3D) visualization involves feature extraction and 3D reconstruction of CT images using a computer processing technology. It is a tool for displaying, describing, and interpreting 3D anatomy and morphological features of organs, thus providing intuitive, stereoscopic, and accurate methods for clinical decision-making. It has played an increasingly significant role in the diagnosis and management of liver diseases. Read More

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http://dx.doi.org/10.1007/s12072-020-10052-yDOI Listing

Magnetic Resonance Diffusion Kurtosis Imaging versus Diffusion-Weighted Imaging in Evaluating the Pathological Grade of Hepatocellular Carcinoma.

Cancer Manag Res 2020 29;12:5147-5158. Epub 2020 Jun 29.

Cheeloo College of Medicine, Shandong University, Jinan 250021, People's Republic of China.

Purpose: To investigate the diagnostic efficacy of diffusion kurtosis imaging (DKI) and conventional diffusion-weighted imaging (DWI) for pathological grading.

Methods: From December 2015 to January 2017, consecutive patients suspected of having hepatocellular carcinoma (HCC) without prior treatment were prospectively enrolled in this study. MRI examinations were performed before surgical treatment. Read More

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http://dx.doi.org/10.2147/CMAR.S254371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334009PMC

Histone-fold centromere protein W (CENP-W) is associated with the biological behavior of hepatocellular carcinoma cells.

Bioengineered 2020 Dec;11(1):729-742

Molecular Imaging Center, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University , Zhuhai, China.

Centromere protein W (CENP-W), identified as a centromeric component, plays an important role in the cell life cycle. However, how expression affects biological processes in liver cancer cells remains unknown. In this article, we found that was overexpressed in liver cancer tissues. Read More

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http://dx.doi.org/10.1080/21655979.2020.1787776DOI Listing
December 2020

Molecular MRI of the Immuno-Metabolic Interplay in a Rabbit Liver Tumor Model: A Biomarker for Resistance Mechanisms in Tumor-targeted Therapy?

Radiology 2020 Jul 7:200373. Epub 2020 Jul 7.

From the Department of Radiology and Biomedical Imaging (L.J.S., L.A.D., I.T.S., J.J.W., J.S., M.D.L., L.A., A.B., J.D., F.H., D.C., J.C.), Department of Internal Medicine, Section of Rheumatology (R.R.M., L.L., R.J.B.), Department of Immunobiology (N.J.), and Department of Pathology (V.P., X.Z.), Yale University School of Medicine, 300 Cedar St, New Haven, CT 06520; Institute of Radiology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität, and Berlin Institute of Health, Berlin, Germany (L.J.S., L.A.D., I.T.S., L.A.); Visage Imaging, San Diego, Calif (M.D.L.); Department of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, Conn (J.D.); and Department of Radiology, Hadassah Hebrew University Medical Center, Jerusalem, Israel (S.N.G.).

Background The immuno-metabolic interplay has gained interest for determining and targeting immunosuppressive tumor micro-environments that remain a barrier to current immuno-oncologic therapies in hepatocellular carcinoma. Purpose To develop molecular MRI tools to reveal resistance mechanisms to immuno-oncologic therapies caused by the immuno-metabolic interplay in a translational liver cancer model. Materials and Methods A total of 21 VX2 liver tumor-bearing New Zealand white rabbits were used between October 2018 and February 2020. Read More

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http://dx.doi.org/10.1148/radiol.2020200373DOI Listing

Post-Treatment M2BPGi Level and the Rate of Autotaxin Reduction are Predictive of Hepatocellular Carcinoma Development after Antiviral Therapy in Patients with Chronic Hepatitis C.

Int J Mol Sci 2020 Jun 25;21(12). Epub 2020 Jun 25.

Department of Central Clinical Laboratory, Osaka City University Hospital, 1-5-7, Asahi-machi, Abeno-ku, Osaka-shi, Osaka 545-8586, Japan.

Patients with chronic hepatitis C virus (HCV) develop hepatocellular carcinoma (HCC) regardless of achieving a sustained viral response (SVR). Because advanced liver fibrosis is a powerful risk factor for HCC, we analyzed the association between autotaxin (ATX), a liver fibrosis marker, and post-SVR HCC development within 3 years after antiviral treatment. We included 670 patients with HCV who received direct-acting antivirals, achieved SVR and were followed up for at least 6 months (270 of them were followed up for 3 years or more). Read More

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http://dx.doi.org/10.3390/ijms21124517DOI Listing

Au speckled SPION@SiO2 nanoparticles decorated with thiocarbohydrates for ASGPR1 targeting towards HCC dual mode imaging potential application.

Chemistry 2020 Jul 6. Epub 2020 Jul 6.

Consiglio Nazionale delle Ricerche, IPCF, Bari, ITALY.

Efforts are made to perform an early and accurate detection of hepatocellular carcinoma (HCC) by simultaneous exploiting multiple clinically non-invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging.  Superparamagnetic nanoparticles (SPIONs) and Au nanoparticles (NPs) possess well-established contrasting features in magnetic resonance imaging (MRI) and X-Ray Computed Tomography (CT), respectively. Read More

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http://dx.doi.org/10.1002/chem.202002142DOI Listing
July 2020
5.731 Impact Factor

Anticancer effect of caudatin in diethylnitrosamine‑induced hepatocarcinogenesis in rats.

Mol Med Rep 2020 Aug 7;22(2):697-706. Epub 2020 May 7.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, P.R. China.

An overwhelming endoplasmic reticulum stress (ERS) and the following unfolded protein response (UPR) can induce hepatic inflammation, fibrosis and hepatocellular carcinoma (HCC). Caudatin, one of the species of C‑21 steroidal glycosides mainly isolated from the roots of Cynanchum bungei Decne, exhibits potent anticancer activities in vivo. However, the effect of caudatin on HCC remains unclear. Read More

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http://dx.doi.org/10.3892/mmr.2020.11135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339819PMC

Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.

Front Endocrinol (Lausanne) 2020 18;11:340. Epub 2020 Jun 18.

Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University Graz, Graz, Austria.

Non-alcoholic fatty liver disease (NAFLD) contributes essentially to the burden of obesity and can start in childhood. NAFLD can progress to cirrhosis and hepatocellular carcinoma. The early phase of NAFLD is crucial because during this time the disease is fully reversible. Read More

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http://dx.doi.org/10.3389/fendo.2020.00340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314945PMC

US LI-RADS visualization score: diagnostic outcome of ultrasound-guided focal hepatic lesion biopsy in patients at risk for hepatocellular carcinoma.

Ultrasonography 2020 May 9. Epub 2020 May 9.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: This study investigated the diagnostic outcome of ultrasound (US)-guided focal hepatic lesion biopsy in patients at risk for hepatocellular carcinoma (HCC) and evaluated the US visualization score as a risk factor for non-diagnostic results.

Methods: We retrospectively evaluated 208 focal hepatic lesions in 208 patients who underwent US-guided biopsy in 2016. Using the US Liver Imaging Reporting and Data System version 2017, each exam was assigned a US visualization score (A, B, or C). Read More

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http://dx.doi.org/10.14366/usg.19066DOI Listing

Preoperative Pathological Grading of Hepatocellular Carcinoma Using Ultrasomics of Contrast-Enhanced Ultrasound.

Acad Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Medical Ultrasonics, Ultrasomics Artificial Intelligence X-Lab, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address:

Rationale And Objectives: To develop an ultrasomics model for preoperative pathological grading of hepatocellular carcinoma (HCC) using contrast-enhanced ultrasound (CEUS).

Material And Methods: A total of 235 HCCs were retrospectively enrolled, including 65 high-grade and 170 low-grade HCCs. Representative images of four-phase CEUS were selected from the baseline sonography, arterial, portal venous, and delayed phase images. Read More

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http://dx.doi.org/10.1016/j.acra.2020.05.033DOI Listing
July 2020
2.077 Impact Factor

Radioembolization-induced Tumor Calcifications as a Surrogate Marker of Tumor Response in Patients With Hepatocellular Carcinoma.

Anticancer Res 2020 Jul;40(7):4191-4198

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background/aim: Tumoral calcification after chemotherapy or radiation therapy has been reported in various cancer patients, but not after radioembolization. The purpose of this study was to evaluate the prognostic value of radioembolization-induced tumor calcification of hepatocellular carcinoma (HCC) treated by radioembolization.

Patients And Methods: This retrospective study comprised patients with single nodular HCC who underwent yttrium-90 radioembolization between November 2015 and April 2019. Read More

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http://dx.doi.org/10.21873/anticanres.14419DOI Listing

Pathological Validity of Using Near-infrared Fluorescence Imaging for Securing Surgical Margins During Liver Resection.

Anticancer Res 2020 Jul;40(7):3873-3882

Department of General and Gastroenterological Surgery, Showa University School of Medicine, Tokyo, Japan.

Background/aim: This study investigated the use of near-infrared fluorescent imaging for securing safe margins during liver resection.

Patients And Methods: This study included 125 patients who underwent liver tumor resection in 2014-2018. Indocyanine green testing was performed 2-14 days before surgery. Read More

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http://dx.doi.org/10.21873/anticanres.14377DOI Listing

Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes.

Diabet Med 2020 Jul 3. Epub 2020 Jul 3.

Institute of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.

Non-alcoholic fatty liver disease (NAFLD) exists as a spectrum of disease ranging from excessive accumulation of fat within the liver (simple steatosis), inflammation (non-alcoholic steatohepatitis) through to fibrosis, cirrhosis and end-stage liver disease. There is also an increased risk of hepatocellular carcinoma. The principal risk factor for NAFLD is overweight or obesity, along with type 2 diabetes, and NAFLD itself is also a risk factor for incident type 2 diabetes. Read More

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http://dx.doi.org/10.1111/dme.14356DOI Listing

Deep learning LI-RADS grading system based on contrast enhanced multiphase MRI for differentiation between LR-3 and LR-4/LR-5 liver tumors.

Ann Transl Med 2020 Jun;8(11):701

Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, USA.

Background: To develop a deep learning (DL) method based on multiphase, contrast-enhanced (CE) magnetic resonance imaging (MRI) to distinguish Liver Imaging Reporting and Data System (LI-RADS) grade 3 (LR-3) liver tumors from combined higher-grades 4 and 5 (LR-4/LR-5) tumors for hepatocellular carcinoma (HCC) diagnosis.

Methods: A total of 89 untreated LI-RADS-graded liver tumors (35 LR-3, 14 LR-4, and 40 LR-5) were identified based on the radiology MRI interpretation reports. Multiphase 3D T1-weighted gradient echo imaging was acquired at six time points: pre-contrast, four phases immediately post-contrast, and one hepatobiliary phase after intravenous injection of gadoxetate disodium. Read More

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http://dx.doi.org/10.21037/atm.2019.12.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327307PMC

Clinical characteristics of four cancer patients with SARS-CoV-2 infection in Wuhan, China.

Infect Dis Poverty 2020 Jul 2;9(1):82. Epub 2020 Jul 2.

Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Donghu road 169, Wuhan, 430071, China.

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the outbreak of pneumonia in Wuhan. The virus is highly infectious. Patients with cancer might be susceptible to the viral infection because of the immunosuppressive state cause by therapies on tumors. Read More

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http://dx.doi.org/10.1186/s40249-020-00707-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330531PMC

The hepatic lipidome: From basic science to clinical translation.

Adv Drug Deliv Rev 2020 Jun 30. Epub 2020 Jun 30.

Translational Liver Research, Department of Medical Cell BioPhysics, Faculty of Science and Technology, Technical Medical Center, University of Twente, Enschede 7500 AE, the Netherlands. Electronic address:

The liver is the key organ involved in lipid metabolism and transport. Excessive lipid accumulation due to dysregulated lipid metabolism predisposes the liver to steatosis, cirrhosis, and hepatocellular carcinoma. Lipids are generally compartmentalized in specialized organelles called lipid droplets that enable cells to store and release lipids in a regulated manner. Read More

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http://dx.doi.org/10.1016/j.addr.2020.06.027DOI Listing

Efficiency of regional functional liver volume assessment using Gd-EOB-DTPA-enhanced magnetic resonance imaging for hepatocellular carcinoma with portal vein tumor thrombus.

Surg Today 2020 Jul 1. Epub 2020 Jul 1.

Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: We investigated whether functional future remnant liver volume (fFRLV), assessed using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI), could evaluate regional liver function in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT) and help establish the indication for hepatectomy.

Methods: The subjects of this study were 12 patients with PVTT [PVTT(+) group] and 58 patients without PVTT [PVTT(-) group], from among 191 patients who underwent hepatectomy of more than one segment for HCC. We calculated the liver-to-muscle ratio (LMR) in the remnant liver, using EOB-MRI and fFRLV. Read More

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http://dx.doi.org/10.1007/s00595-020-02062-yDOI Listing

Synchronous tumours detected during cancer patient staging: prevalence and patterns of occurrence in multidetector computed tomography.

Pol J Radiol 2020 26;85:e261-e270. Epub 2020 May 26.

Radiology Department, National Cancer Institute Pascale Foundation, Naples, Italy.

Purpose: The incidental detection of one or more additional primary tumours during computed tomography (CT) staging of a patient with known malignancy is rare but possible. This occurrence should be considered by the radiologist when a new lesion is detected, especially if the lesion location is atypical for metastases. The purpose of this report was to document the usefulness of total body CT scan to detect synchronous primary malignancies in cancer patients undergoing a staging workup. Read More

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http://dx.doi.org/10.5114/pjr.2020.95781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315052PMC

Follow-up schedule for initial recurrent hepatocellular carcinoma after ablation based on risk classification.

Cancer Imaging 2020 Jul 1;20(1):42. Epub 2020 Jul 1.

Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.

Background: To date, no standard follow-up guidelines exist regarding patients receiving ablation for initial recurrent hepatocellular carcinoma (HCC). We aimed to explore whether intensive follow-up could benefit these patients.

Methods: We reviewed the clinical data of patients who received complete ablation for initial HCC recurrence after curative treatments in our institution from January 2005 to June 2017. Read More

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http://dx.doi.org/10.1186/s40644-020-00319-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329485PMC

Impact of breath-hold level on positional error aligned by stent/Lipiodol in Hepatobiliary radiotherapy with breath-hold respiratory control.

BMC Cancer 2020 Jul 1;20(1):613. Epub 2020 Jul 1.

Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, National Taiwan University College of Medicine, No. 7, Chung-Shan South Rd, Taipei, 10002, Taiwan.

Background: Respiratory motion management with breath hold for patients with hepatobiliary cancers remain a challenge in the precise positioning for radiotherapy. We compared different image-guided alignment markers for estimating positional errors, and investigated the factors associated with positional errors under breath-hold control.

Methods: Spirometric motion management system (SDX) for breath holds was used in 44 patients with hepatobiliary tumor. Read More

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http://dx.doi.org/10.1186/s12885-020-07082-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328270PMC

Role of MRI in Evaluation of Spectrum of Liver Lesions in Cirrhotic Patients.

J Assoc Physicians India 2020 Apr;68(4):32-38

Speciality Medical Officer, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra.

MRI provides better intrinsic soft-tissue contrast with more enhanced depiction of even subtly different tissue properties making lesion evaluation easy. Faster sequences which capture arterial sequences better, lack of ionizing radiation and simultaneous evaluation of background liver parenchyma and the liver lesions are additional advantages of using MRI as the imaging technique of choice. Comprehensive liver imaging using MRI now includes T1, T2-weighted imaging and in- and opposed-phase, in addition to dynamic post-contrast imaging with proper breath holding techniques. Read More

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Diagnostic accuracy of ultrasonography in adults with obstructive jaundice.

J Ultrason 2020 15;20(81):e100-e105. Epub 2020 Jun 15.

Department of Radiology, Union Diagnostics and Clinic Services Plc , Yaba, Lagos , Nigeria.

To determine the sensitivity and specificity of ultrasound for detecting the causes of obstructive jaundice. Eighty adult patients with clinical and biochemical features of obstructive jaundice were enrolled in this study. The causes, degrees and levels of ductal obstruction were evaluated sonographically via the transabdominal route. Read More

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http://dx.doi.org/10.15557/JoU.2020.0016DOI Listing

KIAA1522 Promotes the Progression of Hepatocellular Carcinoma via the Activation of the Wnt/β-Catenin Signaling Pathway.

Onco Targets Ther 2020 16;13:5657-5668. Epub 2020 Jun 16.

Department of Oncology, Lianyungang No 1 People's Hospital, Lianyungang, People's Republic of China.

Purpose: was previously identified to play a crucial role in cancer development and progression. However, its functions and underlying mechanisms in hepatocellular carcinoma (HCC) remain elusive.

Materials And Methods: To elucidate the role of in HCC, its expression was assessed using The Cancer Genome Atlas and GEPIA databases. Read More

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http://dx.doi.org/10.2147/OTT.S251157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305824PMC

The Radiosensitizing Effect of Magnolol on Tumor Growth of Hepatocellular Carcinoma.

In Vivo 2020 Jul-Aug;34(4):1789-1796

Department of Emergency Medicine, Cathay General Hospital, Taipei, Taiwan, R.O.C.

Background/aim: Radiation (RT) induced ERK/NF-κB in hepatocellular carcinoma (HCC) has been reported in our previous works; it weakens the toxicity of RT or triggers a radioresistance effect. Thus, combining RT with a suitable NF-κB inhibitor may sensitize HCC to RT. Magnolol, a bioactive compound, was known to have anti-inflammatory and anti-tumor functions. Read More

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http://dx.doi.org/10.21873/invivo.11973DOI Listing

Texture analysis of MR images to identify the differentiated degree in hepatocellular carcinoma: a retrospective study.

BMC Cancer 2020 Jun 30;20(1):611. Epub 2020 Jun 30.

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou city, Jiangsu province, 215000, P.R. China.

Background: To explore the clinical value of texture analysis of MR images (multiphase Gd-EOB-DTPA-enhanced MRI and T2 weighted imaging (T2WI) to identify the differentiated degree of hepatocellular carcinoma (HCC).

Method: One hundred four participants were enrolled in this retrospective study. Each participant performed preoperative Gd-EOB-DTPA-enhanced MR scanning. Read More

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http://dx.doi.org/10.1186/s12885-020-07094-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325565PMC

Proton versus photon radiotherapy for primary hepatocellular carcinoma: a propensity-matched analysis.

Radiat Oncol 2020 Jun 30;15(1):159. Epub 2020 Jun 30.

Department of Radiation Oncology, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Background: Proton radiotherapy has a dosimetric advantage over photon radiotherapy. Many retrospective studies have shown promising results with proton radiotherapy in treating hepatocellular carcinoma (HCC). However, clinical evidence demonstrating the benefit of protons over photons is still limited. Read More

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http://dx.doi.org/10.1186/s13014-020-01605-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325065PMC

Pediatric Hepatoblastoma, Hepatocellular Carcinoma, and Other Hepatic Neoplasms: Consensus Imaging Recommendations from American College of Radiology Pediatric Liver Reporting and Data System (LI-RADS) Working Group.

Radiology 2020 Jun 30:200751. Epub 2020 Jun 30.

From the Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Tex (G.R.S.); Department of Radiology, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pa (J.H.S.); Department of Radiology, Emory University and Children's Healthcare of Atlanta, Atlanta, Ga (A.A.); Department of Diagnostic Imaging, The Hospital for Sick Children and Department of Medical Imaging, University of Toronto, Toronto, Canada (G.B.C.); Department of Radiology, Montefiore Medical Center, Bronx, NY (V.C.); Department of Radiology, Duke University Medical Center, Durham, NC (J.T.D.); Department of Radiology, Mallinckrodt Institute of Radiology, St. Louis Children's Hospital, Washington University School of Medicine, St Louis, Mo (G.K.); Department of Radiology, Nationwide Children's Hospital, Columbus, Ohio (R.K.); Stanford University School of Medicine, Lucile Packard Children's Hospital, Stanford, Calif (M.P.L.); Department of Radiology, Texas Children's Hospital, Houston, Tex (P.M.M.); Nemours Children's Hospital, Nemours Children's Health System, University of Central Florida College of Medicine, Orlando, Fla (D.J.P.); Liver Imaging Group, Department of Radiology, University of California San Diego, San Diego, Calif (C.B.S.); Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio (A.J.T.); and Department of Radiology, University of Cincinnati College of Medicine, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229 (A.J.T.).

Appropriate imaging is imperative in evaluating children with a primary hepatic malignancy such as hepatoblastoma or hepatocellular carcinoma. For use in the adult patient population, the American College of Radiology created the Liver Imaging Reporting and Data System (LI-RADS) to provide consistent terminology and to improve imaging interpretation. At present, no similar consensus exists to guide imaging and interpretation of pediatric patients at risk for developing a liver neoplasm or how best to evaluate a pediatric patient with a known liver neoplasm. Read More

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http://dx.doi.org/10.1148/radiol.2020200751DOI Listing

Biocompatible melanin based theranostic agent for in vivo detection and ablation of orthotopic micro-hepatocellular carcinoma.

Biomater Sci 2020 Jun 30. Epub 2020 Jun 30.

Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, PR China.

Early diagnosis and therapy of hepatocellular carcinoma (HCC) is critical to improve the five-year survival rates of patients. Theranostic agents synergized with photothermal ablation are expected to realize the early detection and treatment of orthotopic HCC. However, conventional metallic nanoagents are limited by their potential bio-toxicity to surrounding normal organs. Read More

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http://dx.doi.org/10.1039/d0bm00825gDOI Listing

Transarterial chemoembolization combined with iodine 125 seeds versus transarterial chemoembolization combined with radiofrequency ablation in the treatment of early- and intermediate-stage hepatocellular carcinoma.

BMC Gastroenterol 2020 Jun 29;20(1):205. Epub 2020 Jun 29.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Transarterial chemoembolization (TACE), radiofrequency ablation (RFA), and iodine 125 seeds implantation are optional treatments for hepatocellular carcinoma (HCC). The aim of this study is to compare the efficacy of the combined treatment of TACE with iodine 125 seeds implantation (TACE-iodine 125) with TACE with RFA (TACE-RFA) in patients with early- and intermediate-stage HCC.

Methods: The study included 112 patients who were diagnosed with early- and intermediate-stage HCC from January 1, 2014, to May 31, 2018. Read More

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http://dx.doi.org/10.1186/s12876-020-01355-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324959PMC

[The long-term prospective study of patients with liver cirrhosis after elimination of the hepatitis C virus].

Ter Arkh 2020 Apr 27;92(2):34-42. Epub 2020 Apr 27.

Sechenov First Moscow State Medical University (Sechenov University).

Aim: To study liver function and portal hypertension, incidence and risk factors of liver-related complications, including hepatocellular carcinoma (HCC), in patients with HCV-related liver cirrhosis achieved sustained virologic response (SVR) after direct-acting antiviral therapy.

Materials And Methods: Patients with HCV-related liver cirrhosis were followed up after achievement SVR with assessment of liver function parameters, portal hypertension, Model for End-stage Liver Disease (MELD) and Сhild Pugh (CP) scores, complications development, including HCC, every 36 months. The median follow-up duration was 24 [18; 30] months after end of treatment. Read More

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http://dx.doi.org/10.26442/00403660.2020.02.000511DOI Listing

Synchronous Hepatocellular Carcinoma in a Patient with Primary Gastric Cancer: An Exceptional Association.

Case Rep Gastroenterol 2020 May-Aug;14(2):299-305. Epub 2020 May 28.

Department of Gastroenterology, Faculty of Medicine, Ibn Al Jazzar, University Hospital of Sahloul, Sousse, Tunisia.

Hepatocellular carcinoma (HCC) is the most frequent type of liver cancer. Liver cirrhosis of any etiology is considered the main risk factor for the development of HCC. However, HCC in noncirrhotic livers remains an uncommon finding. Read More

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http://dx.doi.org/10.1159/000506188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315167PMC

Near-infrared phototherapy for patient-derived orthotopic xenograft model of hepatocellular carcinoma in combination with indocyanine green.

J Photochem Photobiol B 2020 Jun 14;209:111938. Epub 2020 Jun 14.

Division of Convergence Technology, National Cancer Center, Goyang-si, Gyeonggi-do, Republic of Korea. Electronic address:

Background: Hepatocellular carcinoma notably takes up and retains indocyanine green (ICG). Here, we investigated whether patient-derived orthotopic xenograft of hepatocellular carcinoma could accumulate ICG and show full remission via phototherapy.

Methods: NIR light and ICG were tested for cytotoxicity in cancerous cell lines (Huh-7, Hep3B). Read More

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http://dx.doi.org/10.1016/j.jphotobiol.2020.111938DOI Listing

Pathologic response translates to improved patient survival after locoregional treatment for hepatocellular carcinoma: the importance of minimally invasive microwave ablation.

Surg Endosc 2020 Jun 25. Epub 2020 Jun 25.

Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Carolinas Medical Center, 1025 Morehead Medical Drive, Suite 600, Charlotte, NC, 28204, USA.

Background: Hepatectomy or transplantation can serve as curative treatment for early-stage hepatocellular carcinoma (HCC). Unfortunately, as progression remains a reality, locoregional therapies (LRT) for curative or bridging intent have become common. Efficacy on viability, outcomes, and accuracy of imaging should be defined to guide treatment. Read More

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http://dx.doi.org/10.1007/s00464-020-07747-6DOI Listing