116,636 results match your criteria Hepatocellular Carcinoma


Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 Dec 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
8 Reads

Dual functions of STAT3 in LPS-induced angiogenesis of hepatocellular carcinoma.

Biochim Biophys Acta Mol Cell Res 2018 Dec 3. Epub 2018 Dec 3.

Department of Biology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment and SUSTech-HKU Joint Laboratories for Matrix Biology and Diseases, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:

Hepatocellular carcinoma (HCC) is a long-term consequence of chronic inflammatory liver injury. Hepatic injury is associated with a defective intestinal barrier and increased hepatic exposure to bacterial products including lipopolysaccharide (LPS), which promotes hepatocarcinogenesis. Despite its clinical significance, the molecular mediator linking chronic inflammation with HCC development remains to be clarified. Read More

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December 2018
2 Reads

Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.

Clin Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia; Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Electronic address:

Objective: Identification of new molecular markers to enhance early diagnosis, prognosis and/or treatment of hepatocellular carcinoma (HCC) is a need. TOM34 (34 kDa-translocase of the outer mitochondrial membrane) protein expression deregulation has demonstrated to be involved in the growth of many cancers. Here, we aimed at evaluating serum TOM34 and some heat shock proteins (HSPA4, HSPA1B, and HSP90AA1) expressions in hepatitis C virus (HCV)-related cirrhosis and HCV-induced HCC relative to controls and correlating these expressions to the clinicopathological data. Read More

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December 2018
6 Reads

Pharmacological interventions for acute hepatitis C infection.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011644. Epub 2018 Dec 3.

Sheila Sherlock Liver Centre, Royal Free Hospital and the UCL Institute of Liver and Digestive Health, London, UK.

Background: Hepatitis C virus (HCV) is a single-stranded RNA (ribonucleic acid) virus that has the potential to cause inflammation of the liver. The traditional definition of acute HCV infection is the first six months following infection with the virus. Another commonly used definition of acute HCV infection is the absence of HCV antibody and subsequent seroconversion (presence of HCV antibody in a person who was previously negative for HCV antibody). Read More

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December 2018
1 Read

Influence of miR-520e-mediated MAPK signaling pathway on HBV replication and regulation of hepatocellular carcinoma cells via targeting EphA2.

J Viral Hepat 2018 Dec 6. Epub 2018 Dec 6.

Department of Health Examination, Qilu Hospital, Shandong University, Jinan, 250012, China.

We determined the role of miR-520e in the replication of hepatitis B virus (HBV) and the growth of hepatocellular carcinoma (HCC) cells. MiR-520e and EPH receptor A2 (EphA2) in HBV-positive HCC tissues and cells were detected and we studied the impact of miR-520e and the EphA2 receptor in cellular and murine HBV replication models. We find that MiR-520e was up-regulated and EphA2 was down-regulated in HBV-positive HCC tissues and cells. Read More

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December 2018

The need for complete population-based studies on the etiology of liver disease.

Authors:
Paulo S Pinheiro

Hepatology 2018 Dec 6. Epub 2018 Dec 6.

University of Miami School of Medicine, Public Health Sciences, 1120 14th NW St., Don Soffer Clinical Research Building, Miami, Florida, United States.

I read Kim et al.'s "Changing Trends in Etiology- and Ethnicity-Based Annual Mortality Rates of Cirrhosis and Hepatocellular Carcinoma in the US" with great interest. Patterns for hepatocellular carcinoma (HCC) are complex, with disparities likely rooted in etiological differences. Read More

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December 2018
1 Read

Advances in Genomic Hepatocellular Carcinoma Research.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Integrative Sciences and Engineering, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 117456, Singapore.

Background: Hepatocellular carcinoma (HCC) is the cancer with the second highest mortality in the world due to its late presentation and limited treatment options. As such, there is an urgent need to identify novel biomarkers for early diagnosis and develop novel therapies. The availability of Next Generation Sequencing (NGS) data from tumors of liver cancer patients has provided us with invaluable resources to better understand HCC through the integration of data from different sources to facilitate the identification of promising biomarkers or therapeutic targets. Read More

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December 2018

Cholangiolocellular Carcinoma With "Ductal Plate Malformation" Pattern may be Characterized by ARID1A Genetic Alterations.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa.

Cholangiolocellular carcinoma (CLC) is a unique subtype of primary liver carcinoma, which sometimes coexists with hepatocellular carcinoma (HCC), cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma (cHCC-CCA). "Ductal plate malformation" (DPM)-pattern of primary liver carcinoma, which resembles biliary lesions in Caroli disease and von Meyenburg complex, is sometimes associated with CLC. We examined genetic alterations of hTERT promoter (hTERT), IDH1 or 2 (IDH1/2), KRAS, ARID1A, PBRM1, ARID2, BAP1, p53 and their association with histologic features such as proportion of CLC and DPM-pattern in 77 patients with primary liver carcinoma diagnosed as cHCC-CCA or CLC. Read More

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December 2018
1 Read

Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high-fat diet.

Cancer Sci 2018 Dec 6. Epub 2018 Dec 6.

Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan, 329-0498.

Nonalcoholic steatohepatitis (NASH) is a common cause of liver cirrhosis and hepatocellular carcinoma (HCC). However, effective therapeutic strategies for preventing and treating NASH-mediated liver cirrhosis and HCC are lacking. Cholesterol is closely associated with vascular endothelial growth factor (VEGF), a key factor that promotes HCC. Read More

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December 2018

circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.

Cancer Sci 2018 Dec 6. Epub 2018 Dec 6.

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, China.

circular RNAs (circRNAs), a novel class of non-coding RNAs, have emerged as indispensable modulators in human malignancies. Aberrant cellular senescence is a phenotype observed in various cancers. The association of circRNAs with cellular senescence in tumor is still a virgin soil to be upturned. Read More

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December 2018

Proteomic Landscape of Cholangiocarcinomas Reveals 3 Different Subgroups According to their Localization and the Aspect of Non-Tumor Liver.

Proteomics Clin Appl 2018 Dec 6:e1800128. Epub 2018 Dec 6.

UMR 1149 INSERM - Paris Diderot University, Inflammation Research Center, Paris, France.

Purpose: Cholangiocarcinomas (CC), tumors derived from epithelial biliary cells, define a heterogeneous entity based upon their anatomic localization (intra- versus extrahepatic) and, for those developing in the liver, depending on the aspect of non-tumor liver (normal versus cirrhosis). The aim of the study was to characterize the molecular heterogeneity of the different types of CC by a global proteomic approach.

Experimental Design: Thirty-three tumor samples from 17 intrahepatic CC (iCC) including 9 and 8 developed on normal (iCC ) and cirrhotic liver (iCC ), respectively; 5 hilar CC (CC ), 5 CC developed in the pancreatic portion of the bile duct (CC ) and 6 hepatocellular carcinoma (HCC), were submitted to label-free quantitative proteomic analysis. Read More

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December 2018

Hepatic Resection Compared to Chemoembolization in Intermediate to Advanced-Stage HCC: a comment for moving forward.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.

Treatment of hepatocellular carcinoma (HCC) depends on disease staging, which is usually performed according to the Barcelona Clinic Liver Cancer (BCLC) system. Although the BCLC system is recommended in the guidelines from the European Association for the Study of the Liver, the American Association for the Study of Liver Diseases, and the European Society for Medical Oncology , its treatment recommendations for intermediate and advanced HCC are inconsistent with the literature. This article is protected by copyright. Read More

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December 2018
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Stereotactic radiofrequency ablation of hepatocellular carcinoma - A histopathological study in explanted livers.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

INNPATH, Institute of Pathology, Tirol Kliniken Innsbruck, Anichstr. 35, 6020, Innsbruck, Austria.

Background And Rationale For The Study: This retrospective study was performed to evaluate the efficacy of 3D-navigated multi-probe radiofrequency ablation (RFA) with intraprocedural image fusion for the treatment of hepatocellular carcinoma (HCC) by histopathologic examination.

Main Results: From 2009 to 2018, 97 patients (84 men, 13 women; median age 60 years, range 1 -71) were transplanted after bridging therapy of 195 HCCs by stereotactic RFA (SRFA). The median interval between the first SRFA and transplantation was 6. Read More

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December 2018

A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?

Acta Diabetol 2018 Dec 5. Epub 2018 Dec 5.

Azienda Ospedaliero-Universitaria Modena, UO di Medicina Metabolica, Ospedale Civile di Baggiovara, Via Giardini 1135, 41125, Modena, Italy.

Evidence suggests a close relationship between nonalcoholic fatty liver disease (NAFLD) and type two diabetes (T2D). On the grounds of prevalence of disease, both conditions account for a significant financial cost for health care systems and individuals. Aim of this review article is to explore the epidemiological basis and the putative molecular mechanisms underlying the association of NAFLD with T2D. Read More

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December 2018
2 Reads

Nonalcoholic Fatty Liver Disease Demonstrates a Pre-fibrotic and Premalignant Molecular Signature.

Dig Dis Sci 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, University of Massachusetts Boston, Boston, USA.

Background: Metabolic syndrome contributing to nonalcoholic fatty liver disease (NAFLD) can lead to hepatic dysfunction, steatohepatitis, cirrhosis, and hepatocellular carcinoma.

Aims: In this study, we tested whether diet-induced fatty liver in a mouse model physiologically mimicked human NAFLD, and whether transcriptional alterations in mouse fatty liver signified risk for the development of hepatitis, cirrhosis, and/or hepatocellular carcinoma.

Methods: SAMP6 strain mice were fed a low-fat diet or high-fat diet (HFD) for 6 months. Read More

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December 2018
1 Read

ASO Author Reflections: Annexin A3 as a Potential Biomarker for Hepatocellular Carcinoma.

Ann Surg Oncol 2018 Dec 5. Epub 2018 Dec 5.

Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

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December 2018

Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist.

Authors:
Alberto Quaglia

J Hepatocell Carcinoma 2018 8;5:99-108. Epub 2018 Nov 8.

Department of Cellular Pathology, Royal Free Hospital, London NW3 2QG, UK,

Histopathologists retain a critical role in the diagnosis and management of hepatocellular carcinoma (HCC). HCC arises usually but not exclusively in a background of advanced-stage chronic liver disease. The histological diagnosis of HCC poses many challenges particularly when dealing with liver biopsy specimens due to the heterogeneity of HCC and the difficulty to confirm hepatocellular differentiation in some instances. Read More

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November 2018

Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

J Cancer 2018 31;9(23):4440-4448. Epub 2018 Oct 31.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 in testicular germ cell tumors (TGCTs) is unclear at present. Read More

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October 2018

Autophagy Plays a Critical Role in Insulin Resistance- Mediated Chemoresistance in Hepatocellular Carcinoma Cells by Regulating the ER Stress.

J Cancer 2018 21;9(23):4314-4324. Epub 2018 Oct 21.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P.R. China.

The high mortality of hepatocellular carcinoma (HCC) patients is associated with several independent risk factors including type 2 diabetes mellitus (T2DM) and insulin resistance (IR), which could be caused by various pathological processes such as tumorigenesis and inflammation in the liver. In previous report, we declared that IR contributes to multidrug resistance in HCC by activation of endoplasmic reticulum (ER) stress. Here, our study revealed that the enhanced autophagy induced by IR significantly prompts the chemotherapeutic drug resistance in hepatoma cells, which was validated by stimulation and inhibition of the autophagy respectively. Read More

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October 2018

Polymorphisms Contribute to Hepatocellular Carcinoma Susceptibility in Chinese Population with Liver Cirrhosis: A Case-Control Study.

J Cancer 2018 20;9(22):4294-4300. Epub 2018 Oct 20.

Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Single nucleotide variations in the liver fatty acid binding protein () gene lead to changes in cellular signaling pathways and lipid metabolism. polymorphisms were associated with some liver diseases, like steatotic hepatocellular carcinoma. However, the association between rs1545224 and rs2241883 polymorphisms and hepatitis B virus-related liver cirrhosis (LC) and hepatocellular carcinoma (HCC) has not been reported. Read More

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October 2018
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A Nomogram Predicting Extrahepatic Metastases for Patients with Adjuvant Transarterial Chemoembolization after Hepatectomy.

J Cancer 2018 20;9(22):4223-4233. Epub 2018 Oct 20.

Department of Laboratory Medicine, Third Affiliated Hospital of Second Military Medical University, Shanghai, China.

Prognosis remains poor for hepatocellular carcinoma (HCC) patients with extrahepatic metastases (EHMs). This study aimed to develop a nomogram to predict EHMs in HCC patients who underwent adjuvant transarterial chemoembolization (TACE) following hepatectomy. Data of 578 HCC patients who underwent TACE after hepatectomy at the Eastern Hepatobiliary Surgery Hospital was retrospectively reviewed. Read More

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October 2018
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MicroRNA-376c-3p Facilitates Human Hepatocellular Carcinoma Progression via Repressing AT-Rich Interaction Domain 2.

J Cancer 2018 18;9(22):4187-4196. Epub 2018 Oct 18.

Department of Infectious Diseases, the Second Affiliated Hospital of Xi'an Jiaotong University, 157 Xiwu Road, Xi'an 710004, China.

Hepatocellular carcinoma (HCC), accounting for approximately 90% of liver cancer, is the most lethal malignant tumors in the world. Large amount of evidence indicate that microRNAs (miRNAs) contribute to the tumorigenesis and progression of HCC. Among them, miR-376c-3p was recently identified as a tumor-related miRNA and is up-regulated in HBV-related HCC. Read More

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October 2018

Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway.

J Cancer 2018 18;9(22):4150-4155. Epub 2018 Oct 18.

Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, P.R. China.

: Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor worldwide, with a high mortality rate at advanced stages. In this study, we investigated the effect of niclosamide on cell growth and drug sensitivity in human HCC and elucidated the underlying mechanism. Three human HCC cell lines (HepG2, QGY-7703 and SMMC-7721) were used to evaluate the effect of niclosamide. Read More

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October 2018

(L.) P. Royen Leaf Water Extract Induces Apoptosis in Human Hepatocellular Carcinoma (HepG2) Cells via ERK1/2/Akt1/JNK1 Signaling Pathways.

Evid Based Complement Alternat Med 2018 5;2018:7826576. Epub 2018 Nov 5.

Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

(L.) P. Royen, called sapodilla, or locally known as , belongs to the family . Read More

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November 2018
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Long-Term Cholic Acid Treatment in a Patient with Zellweger Spectrum Disorder.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):661-670. Epub 2018 Nov 21.

Division of Pediatric Gastroenterology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.

Zellweger spectrum disorders (ZSDs) are a subgroup of peroxisomal biogenesis disorders with a generalized defect in peroxisome function. Liver disease in ZSDs has been associated with the lack of peroxisomal β-oxidation of C-bile acid intermediates to form primary C-bile acids, which prevents normal physiologic feedback and leads to accumulation of hepatotoxic bile acid intermediates. Primary bile acid therapy, oral cholic acid (CA), as adjunctive treatment for ZSDs, restores physiologic feedback inhibition on bile acid synthesis and inhibits formation of hepatotoxic bile acid intermediates. Read More

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November 2018

Spontaneous Pathological Complete Regression of Hepatocellular Carcinoma.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):653-659. Epub 2018 Nov 14.

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

Several possible mechanisms for spontaneous regression of hepatocellular carcinoma (HCC) have been reported. Spontaneous complete regression of HCC is extremely rare. We herein report a case of spontaneous pathological complete regression of HCC following decrement of elevated serum alpha-fetoprotein (AFP). Read More

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November 2018
1 Read

Overexpression of RALY promotes migration and predicts poor prognosis in hepatocellular carcinoma.

Cancer Manag Res 2018 9;10:5559-5572. Epub 2018 Nov 9.

Organ Transplant Center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Guangdong, China,

Introduction: RALY plays a critical role in promoting invasiveness and is associated with poor prognosis in different types of cancers. However, the prognostic value of RALY and its precise role in hepatocellular carcinoma (HCC) remain unknown.

Materials And Methods: We detected the expression of RALY in 127 clinical HCC tissue samples and seven HCC cell lines by immunohistochemical staining and Western blotting. Read More

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November 2018

Transarterial chemoembolization with radiofrequency ablation versus hepatectomy in hepatocellular carcinoma beyond the Milan criteria: a retrospective study.

Cancer Manag Res 2018 8;10:5545-5552. Epub 2018 Nov 8.

Minimally Invasive and Interventional Department, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China,

Purpose: To compare the efficacies of transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) with hepatectomy. Prognostic factors for the patient groups were analyzed.

Patients And Methods: Data of 314 newly diagnosed cases of hepatocellular carcinoma beyond the Milan criteria were studied from January 2012 to December 2013 in our hospital. Read More

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November 2018

miR-517a promotes Warburg effect in HCC by directly targeting FBP1.

Onco Targets Ther 2018 13;11:8025-8032. Epub 2018 Nov 13.

Department of Hepatobiliary Surgery, Guizhou People's Hospital, Guiyang 550002, China,

Purpose: Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies worldwide. Our aim is to explore the expression and biological function of miR-517a in HCC.

Materials And Methods: We performed qRT-PCR to detect the expression of miR-517a in clinical samples and cell lines. Read More

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November 2018

MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10.

Onco Targets Ther 2018 9;11:7919-7934. Epub 2018 Nov 9.

Department of General Surgery, Tianjin Medical University General Hospital, Tianjin, China,

Background: Hepatocellular carcinoma (HCC) is known to feature several microRNA dysregulations. This study aimed to determine and investigate the prognostic value of microRNA (miRNA/miR)-18a and its role in regulating the progression of HCC.

Methods: miR-18a expressions in human HCC tissues, pair-matched adjacent normal liver tissues as well as in HCC cell lines were determined by quantitative real-time PCR. Read More

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November 2018

HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.

Cell Death Dis 2018 Dec 5;9(12):1176. Epub 2018 Dec 5.

Jiangsu Cancer Biotherapy Institute, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China.

Hepatocellular carcinoma-related protein-1 (HCRP-1), a subunit of mammalian endosomal sorting complex required for transport-I (ESCRT-I), is frequently downregulated in various kinds of malignant tumors. The role of HCRP-1 in colorectal cancer (CRC) remains unknown. We investigate the clinical value of HCRP-1 and its impact on anoikis in CRC. Read More

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December 2018
1 Read

Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators.

Nat Rev Gastroenterol Hepatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Interdisciplinary Medicine, Aldo Moro University of Bari, Bari, Italy.

Alterations of hepatic metabolism are critical to the development of liver disease. The peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on a transcriptional level, different aspects of liver metabolism, such as mitochondrial oxidative phosphorylation, gluconeogenesis and fatty acid synthesis. As modifications affecting both mitochondrial and lipid metabolism contribute to the initiation and/or progression of liver steatosis, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), a link between disrupted PGC1 pathways and onset of these pathological conditions has been postulated. Read More

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December 2018
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A novel lncRNA, TCONS_00006195, represses hepatocellular carcinoma progression by inhibiting enzymatic activity of ENO1.

Cell Death Dis 2018 Dec 5;9(12):1184. Epub 2018 Dec 5.

Department of Infectious Diseases, Hunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South University, Changsha, China.

Hepatocellular carcinoma (HCC) is one of the most common malignancies and has an unfavorable prognosis. The hepatitis B virus X (HBx) protein has been reported to be closely associated with hepatocarcinogenesis. Meanwhile, emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in the pathogenesis and progression of cancers. Read More

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December 2018
2 Reads

T cell dysfunction in chronic hepatitis B infection and liver cancer: evidence from transcriptome analysis.

J Med Genet 2018 Dec 5. Epub 2018 Dec 5.

Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Background: T cell dysfunction occurs in many diseases, especially in chronic virus infection and cancers. However, up to now, little is known on the distinctions in T cell exhaustion between cancer and chronic virus infection. The objective of this study is to explore the transcriptional similarities and differences in exhausted CD8 +T cell between chronic hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Read More

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December 2018

Demographic and facility volume related outcomes in radiofrequency ablation for early-stage hepatocellular carcinoma.

HPB (Oxford) 2018 Dec 3. Epub 2018 Dec 3.

University of California, Irvine School of Medicine, Department of Radiological Sciences, 101 The City Drive South, Orange, CA 92868, USA.

Background: To evaluate outcomes related to disparities in facility volume and patient demographics in patients with early-stage hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA).

Methods: This is a retrospective study of patients with stage I/II HCC treated with RFA in the National Cancer Database. Independent contributors to overall survival were determined with Cox regression analysis. Read More

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December 2018

Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species.

Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.

Department of Chemistry, University of Nairobi, P. O. Box 30197, 00100 Nairobi, Kenya.

A phytochemical investigation of the roots of led to the isolation of -kaurane-type diterpenoids and additional phytochemicals (⁻). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the -kaurane-type diterpenoids (⁻, and ) were determined by single crystal X-ray diffraction studies. Read More

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December 2018

Synthesis of new thiazolo-pyrrolidine-(spirooxindole) tethered to 3-acylindole as anticancer agents.

Bioorg Chem 2018 Oct 23;82:423-430. Epub 2018 Oct 23.

Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia; Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Ibrahimia, Alexandria 21321, Egypt. Electronic address:

Anticancer therapeutics with profiles of high potency, low toxicity, and low resistance is of considerable interest. A new series of functionalized spirooxindole linked with 3-acylindole scaffold is reported, starting from chalcones derived from 3-acetyl indole with isatin, and l-4-thiazolidinecarboxylic acid. The reactions proceeded regioselectivity, stereoselectivity, without side products in high yield (71-89%). Read More

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October 2018
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Metabolomic study of natrin-induced apoptosis in SMMC-7721 hepatocellular carcinoma cells by ultra-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry.

Int J Biol Macromol 2018 Nov 30. Epub 2018 Nov 30.

Pharmaceutical College, Guangxi Medical University, Nanning, China. Electronic address:

Natrin, a new member of the cysteine-rich secretory protein (CRISP) family purified from the snake venom of Naja naja atra, has been demonstrated to have anticancer activity. However, the underlying molecular mechanisms need further elucidation. In this study, MTT was used to evaluate cell viability. Read More

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November 2018
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Mitochondria targeting to oppose the progression of nonalcoholic fatty liver disease.

Biochem Pharmacol 2018 Nov 30. Epub 2018 Nov 30.

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy. Electronic address:

Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. Read More

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November 2018

Short-Term Incidence of Sequelae of HCV Infection Among Medicaid Beneficiaries in Oregon.

Public Health Rep 2018 Dec 3:33354918813552. Epub 2018 Dec 3.

1 Oregon Public Health Division, Acute and Communicable Disease Prevention, Oregon Health Authority, Portland, OR, USA.

Objectives:: Given the known high morbidity and mortality of hepatitis C virus (HCV) infection in Oregon, we sought to develop a practical method of estimating the severe sequelae of HCV infection among Medicaid beneficiaries in Oregon.

Methods:: We assembled a retrospective cohort that identified all Oregon Medicaid beneficiaries with HCV infection enrolled for at least 1 year during 2009-2013. We linked this cohort to 3 data sets to identify HCV-related deaths, cases of hepatocellular carcinoma (HCC), and first hospitalizations for advanced liver disease (ALD). Read More

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December 2018

Application of real time contrast-enhanced ultrasound in differential diagnosis of liver malignancies.

Authors:
Hongling Li Jin Li

Can J Physiol Pharmacol 2018 Dec 3. Epub 2018 Dec 3.

Puai Hospital affiliated to Tongji Medical College of Huazhong Science and Technology University, Wuhan, China ;

Objective: To evaluate the value of real time contrast-enhanced ultrasound in differential diagnosis of malignant liver tumors.

Methods: 60 patients pathologically diagnosed with liver cancer from May 2016 to May 2017 were selected as the objects. All patients received ultrasonic diagnosis followed by the observation on dynamic contrast enhancement of the image and the analysis on perfusion characteristics and difference in contrast-enhanced ultrasound results in patients with different types of liver cancer. Read More

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December 2018

LINC00857 contributes to hepatocellular carcinoma malignancy via enhancing epithelial-mesenchymal transition.

J Cell Biochem 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, Liaocheng People's Hospital, 67 Dongchang West Road, Liaocheng, Shandong, China.

Hepatocellular carcinoma (HCC) remains the fifth most frequent cancer with high mortality rate worldwide. However, the underlying molecular mechanisms of HCC progression are still barely known. Long noncoding RNAs (lncRNAs) have been recognized as significant therapeutic targets for HCC. Read More

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December 2018

A modified staging of early and intermediate hepatocellular carcinoma based on single tumour >7 cm and multiple tumours beyond up-to-seven criteria.

Aliment Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.

Hepatopancreatobiliary Surgery Department I, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China.

Background: The Barcelona Clinic Liver Cancer (BCLC) staging system is the most widely used staging system for hepatocellular carcinoma (HCC). However, the classifications of early (BCLC-A) and intermediate (BCLC-B) stage HCC remain controversial.

Aim: To refine the staging of BCLC-A and -B. Read More

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December 2018

Prognostic evaluation of NANOG and OCT4 expression for posttransplantation hepatocellular carcinoma recurrence.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Tianjin Key Laboratory of Organ Transplantation, Tianjin, China.

Postoperative hepatocellular carcinoma (HCC) recurrence and metastasis throw great threaten to its overall survival (OS). This paper focus on exploring the prognostic significance of NANOG and OCT4 expression in HCC recurrence and OS after liver transplantation. Eighty-six patients who meet University of California San Francisco (UCSF) criteria and underwent liver transplantation in Tianjin First Central Hospital between August 2010 and August 2013 were included. Read More

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December 2018
3.263 Impact Factor

LOXL2 promotes vasculogenic mimicry and tumour aggressiveness in hepatocellular carcinoma.

J Cell Mol Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Pathology, Tianjin Medical University, Tianjin, China.

Lysyl oxidase-like 2 (LOXL2) has shown to promote metastasis and poor prognosis in hepatocellular carcinoma (HCC). Also, we have previously reported that vasculogenic mimicry (VM) is associated with invasion, metastasis and poor survival in HCC patients. In the present study, we investigated molecular function of LOXL2 in HCC and VM. Read More

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December 2018

Vitamin E Improves Transplant-free Survival and Hepatic Decompensation among Patients with NASH and Advanced Fibrosis.

Hepatology 2018 Dec 1. Epub 2018 Dec 1.

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN, U.S.

Vitamin E improves liver histology in non-diabetic adults with nonalcoholic steatohepatitis (NASH), but its impact on long-term patient outcomes is unknown. We evaluated whether vitamin E treatment improves clinical outcomes of NASH patients with bridging fibrosis or cirrhosis. Two hundred and thirty-six patients with biopsy-proven NASH and bridging fibrosis or cirrhosis seen at Indiana University Medical Center between October 2004, and January 2016 were included. Read More

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December 2018
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Vessels that encapsulate tumor clusters (VETC) pattern is a predictor of sorafenib benefit in patients with hepatocellular carcinoma.

Hepatology 2018 Dec 1. Epub 2018 Dec 1.

MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Sorafenib is the most recommended first-line systemic therapy for advanced hepatocellular carcinoma (HCC). Yet there is no clinically applied biomarker for predicting sorafenib response. We have demonstrated that a vascular pattern, named VETC (vessels that encapsulate tumor clusters), facilitates the release of whole tumor clusters into the bloodstream; VETC-mediated metastasis relies on vascular pattern but not on the migration and invasion of cancer cells. Read More

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December 2018
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Dietary patterns and risk of hepatocellular carcinoma among US men and women.

Hepatology 2018 Dec 1. Epub 2018 Dec 1.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and, Harvard Medical School, Boston, MA, USA.

Although adherence to healthy dietary guidelines has been associated with a reduced risk of several health outcomes including cardiovascular diseases, type 2 diabetes, and some cancers, little is known about the role of dietary patterns in the development of hepatocellular carcinoma. We prospectively assessed the associations of 3 key commonly used a priori dietary patterns, the Alternative Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH) with risk of incident hepatocellular carcinoma in the Health Professionals Follow-up Study and the Nurses' Health Study, two large prospective cohort studies. Diet was assessed almost every 4 years using validated food frequency questionnaires. Read More

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December 2018
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The correlation and prognostic value of serum levels of soluble programmed death protein 1 (sPD-1) and soluble programmed death-ligand 1 (sPD-L1) in patients with hepatocellular carcinoma.

Cancer Immunol Immunother 2018 Dec 1. Epub 2018 Dec 1.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, Guangdong, People's Republic of China.

Background: Blocking the programmed death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway in hepatocellular carcinoma (HCC) is a very promising approach in immunotherapy. However, the correlation and prognostic values of serum soluble PD-1 and PD-L1 (sPD-1/sPD-L1) have not been explored conjointly in HCC patients.

Methods: This study retrospectively included 120 HCC patients receiving radical resection. Read More

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December 2018
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Independent and additive effects of PNPLA3 and TM6SF2 polymorphisms on the development of non-B, non-C hepatocellular carcinoma.

J Gastroenterol 2018 Nov 30. Epub 2018 Nov 30.

Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: This study was aimed at evaluating the association between single nucleotide polymorphisms (SNPs) in the PNPLA3, NCAN, TM6SF2 and MBOAT7 and hepatocellular carcinoma (HCC) development in Thai patients according to underlying etiologies of liver disease.

Methods: These SNPs were determined by allelic discrimination in blood samples of 105 healthy controls and 530 patients with HCC [270 with hepatitis B virus (HBV-HCC), 131 with hepatitis C virus (HCV-HCC), and 129 with non-B, non-C HCC (NBNC-HCC) matched for age and gender].

Results: G allele of PNPLA3 rs738409 variant was significantly higher in NBNC-HCC (49%) compared to healthy controls (32%), HBV-HCC (32%) and HCV-HCC (31%) (P < 0. Read More

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November 2018