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Clin Biochem 2022 Jun 24. Epub 2022 Jun 24.

Department of Laboratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address:

Background: There is growing evidence that long non-coding RNAs (lncRNAs) play important roles in the progression of hepatocellular carcinoma (HCC) and may serve as diagnostic markers. This study investigates the diagnostic efficiency of the long intergenic non-protein-coding RNA 1793 (LINC01793) in hepatitis B virus (HBV)-related HCC.

Methods: Bioinformatics methods were used to screen the aberrantly expressed lncRNAs in HCC tissues based on The Cancer Genome Atlas (TCGA). Read More

Clin Res Hepatol Gastroenterol 2022 Jun 24:101927. Epub 2022 Jun 24.

Pathol Res Pract 2022 Jun 18;236:153988. Epub 2022 Jun 18.

Department of Epidemiology and Medical Statistics, School of Public Health, Nantong University, Nantong, China. Electronic address:

Background: Systematic research on the associations between vital single nucleotide polymorphisms (SNPs) in MALAT1 and cancer risk was still lacking. Thus, we performed this study.

Materials And Methods: The literature searches were until April 1, 2022. Read More

J Cancer Res Clin Oncol 2022 Jun 27. Epub 2022 Jun 27.

Department of Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Background: Gallbladder cancer (GBC) is a rare malignant tumour of the bile duct. Due to the lack of typical clinical manifestations in the early stage, it is basically at an advanced stage when discovered. Radical resection remains the only curative therapy for patients with GBC. Read More

Int J Radiat Biol 2022 Jun 27:1-30. Epub 2022 Jun 27.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Introduction: External beam radiation therapy (EBRT) is commonly used as a palliative treatment for bone metastases of hepatocellular carcinoma (HCC). We planned a hybrid systematic review that meta-analyzed the efficacy and feasibility of EBRT and reviewed the literature to answer specific clinical questions.

Methods: The PubMed, Medline, Embase, and Cochrane Library databases were searched through December 1, 2021. Read More

Egypt J Immunol 2022 Jul;29(3):36-43

Department of Tropical Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Hepatitis C virus (HCV) infection related complications including fibrosis, cirrhosis and hepatocellular carcinoma (HCC) are influenced by host genetic factors. Identification of emerging host genetic variations is of promising value. Disheveled EGL-10 and pleckstrin domain-containing 5 (DEPDC5) rs1012068 T/G gene polymorphism has been implicated in liver disease. Read More

Biosci Rep 2022 Jun;42(6)

Expert Rev Mol Diagn 2022 Jun 25. Epub 2022 Jun 25.

Department of internal medicine, Hematology/Oncology division, American University of Beirut Medical Center, Riad El Solh, Beirut, Lebanon.

Introduction: The diagnosis of hepatocellular carcinoma (HCC) is made at a relatively advanced stage resulting in poor prognosis. Alpha-fetoprotein and liver ultrasound have limited accuracy as biomarkers in HCC. Liver biopsy provides information on tumor biology; however, it is invasive and holds high threat of tumor seeding. Read More

Ther Adv Chronic Dis 2022 21;13:20406223221102791. Epub 2022 Jun 21.

Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Background: Both tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are known to reduce the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). This study aimed to compare the difference in HCC risk reduction between TDF and ETV in treatment-naïve patients with CHB-related compensated cirrhosis.

Methods: Patients with compensated cirrhosis initially treated with TDF or ETV at nine Chinese hospitals between June 2014 and March 2021 were enrolled in this retrospective study. Read More

Front Immunol 2022 9;13:868809. Epub 2022 Jun 9.

Department of Infectious Diseases and Hepatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: The clinical significance of liver stiffness (LS) measured by shear wave elastography (SWE) in programmed cell death protein-1 (PD-1) inhibitors treated advanced hepatocellular carcinoma (HCC) patients remains unknown. This study aimed to explore the prognostic value of baseline LS by SWE prior to PD-1 inhibitor treatment in combination with lenvatinib.

Methods: We retrospectively evaluated patients (n=133) with HCC who received anti-PD-1 antibodies plus lenvatinib at two high-volume medical centres, between January 2020 and June 2021. Read More

Front Immunol 2022 10;13:896752. Epub 2022 Jun 10.

Department of Gastroenterology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang, China.

Hepatocellular carcinoma (HCC) is usually diagnosed in an advanced stage and has become the second deadliest type of cancer worldwide. The systemic treatment of advanced HCC has been a challenge, and for decades was limited to treatment with tyrosine kinase inhibitors (TKIs) until the application of immune checkpoint inhibitors (ICIs) became available. Due to drug resistance and unsatisfactory therapeutic effects of monotherapy with TKIs or ICIs, multi-ICIs, or the combination of ICIs with antiangiogenic drugs has become a novel strategy to treat advanced HCC. Read More

Front Immunol 2022 10;13:845585. Epub 2022 Jun 10.

Medical Research Center, Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, China.

The is a main activator of ATPase of Hsp90. Hsp90 is involved in various metabolic and developmental processes of tumor cells. Although, the role of in tumor cells is still unrecognized. Read More

Front Endocrinol (Lausanne) 2022 9;13:901495. Epub 2022 Jun 9.

The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.

The Warburg effect, one of the hallmarks of tumors, produces large amounts of lactate and generates an acidic tumor microenvironment using glucose for glycolysis. As a metabolite, lactate not only serves as a substrate to provide energy for supporting cell growth and development but also acts as an important signal molecule to affect the biochemical functions of intracellular proteins and regulate the biological functions of different kinds of cells. Notably, histone lysine lactylation (Kla) is identified as a novel post-modification and carcinogenic signal, which provides the promising and potential therapeutic targets for tumors. Read More

Oncoimmunology 2022 15;11(1):2088467. Epub 2022 Jun 15.

Immunology Translational Research Programme, Department of Microbiology of Immunology, Yong Loo Lin School of Medicine, Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore.

Interleukin-1α (IL-1α) plays an important role in inflammation and hematopoiesis. Many tumors have increased IL-1α expression. However, the immune regulatory role of secreted IL-1α in tumor development and whether it can be targeted for cancer therapy are still unclear. Read More

Front Oncol 2022 8;12:893268. Epub 2022 Jun 8.

Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, China.

Background: Tumor recurrence after hepatectomy is high for hepatocellular carcinoma (HCC), and minimal residual disease (MRD) could be the underlying mechanism. A predictive model for recurrence and presence of MRD is needed.

Methods: Common inflammation-immune factors were reviewed and selected to construct novel models. Read More

Front Oncol 2022 8;12:899404. Epub 2022 Jun 8.

Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Purpose: To investigate the value of radiomics features derived from preoperative multi-sequence MR images for predicting early recurrence (ER) in patients with solitary hepatocellular carcinoma (HCC) ≤5 cm.

Methods: One hundred and ninety HCC patients were enrolled and allocated to training and validation sets (n = 133:57). The clinical-radiological model was established by significant clinical risk characteristics and qualitative imaging features. Read More

Front Oncol 2022 8;12:919880. Epub 2022 Jun 8.

Brody School of Medicine, Department of Physiology, East Carolina University, Greenville, NC, United States.

Hepatocellular carcinoma (HCC) is the most common form of liver cancer worldwide. Increasing evidence suggests that mitochondria play a central role in malignant metabolic reprogramming in HCC, which may promote disease progression. To comprehensively evaluate the mitochondrial phenotype present in HCC, we applied a recently developed diagnostic workflow that combines high-resolution respirometry, fluorometry, and mitochondrial-targeted nLC-MS/MS proteomics to cell culture (AML12 and Hepa 1-6 cells) and diethylnitrosamine (DEN)-induced mouse models of HCC. Read More

Front Oncol 2022 8;12:759864. Epub 2022 Jun 8.

Department of Intensive Care Unit of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Laboratory of South China Structural Heart Disease, Guangzhou, China.

Background: Emerging evidence has shown that exosome microRNAs (miRNAs) regulate the development of hepatocellular carcinoma (HCC). Here, the influences of miR-4800-3p on the progression of HCC were explored.

Materials And Methods: The expression of miR-4800-3p in the exosome derived by transforming growth factor beta 1 (TGF-β1)-treated HCC cells and the serum exosome isolated from HCC patients were identified by real-time PCR. Read More

Clin Med Insights Oncol 2022 20;16:11795549221105027. Epub 2022 Jun 20.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

Background: Volatile organic compounds (VOCs) have been involved in cancer diagnosis via breath, urine, and feces. We aimed to assess the diagnostic ability of VOCs on digestive cancers.

Methods: We systematically reviewed prospective clinical trials evaluating VOCs' diagnostic ability on esophageal, gastric, colorectal, hepatic, and pancreatic cancer (PC). Read More

Front Genet 2022 8;13:898507. Epub 2022 Jun 8.

Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, Nantong, China.

Hepatocellular carcinoma (HCC) is among malignancies with the highest fatality toll globally and minimal therapeutic options. Necroptosis is a programmed form of necrosis or inflammatory cell death, which can affect prognosis and microenvironmental status of HCC. Therefore, we aimed to explore the prognostic value of necroptosis-related lncRNAs (NRLs) in HCC and the role of the tumor microenvironment (TME) in immunotherapy. Read More

Front Genet 2022 8;13:904114. Epub 2022 Jun 8.

Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Hepatitis A virus cellular receptor (HAVCR1) is a type-1 integral membrane glycoprotein that plays a key role in immunity and renal regeneration and is abnormally expressed in various tumor types. Nonetheless, the function of HAVCR1 in pan-cancer remains unknown. In this study, we comprehensively analyzed the expression and promoter methylation level of HAVCR1 and assessed the immune cell infiltration, correlation between stromal and immune cell admixture, CD (Cluster of Differentiation) and HAVCR1 expression and prognostic value of HAVCR1 mRNA expression in Liver hepatocellular carcinoma (LIHC) and Pancreatic adenocarcinoma (PAAD). Read More

Evid Based Complement Alternat Med 2022 15;2022:6084321. Epub 2022 Jun 15.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Background: The aim of this study is to explore the interactions between effective monomers of herbal formulas and their therapeutic targets using systems biology approaches which may be a promising approach to unraveling their underlying mechanisms. Shentao Ruangan decoction (STRGD), which has been experimentally, clinically demonstrated to be effective in treating liver hepatocellular carcinoma (LIHC), was selected.

Methods: Bioactive ingredients and drug targets of STRGD were retrieved from the traditional Chinese medicine systems pharmacology database and analysis platform and BATMAN-TCM databases. Read More

Immunooncol Technol 2020 Sep 25;7. Epub 2020 Jun 25.

Department of Biomedical Sciences, City University of Hong Kong, Kowloon, Hong Kong SAR.

Antioxid Redox Signal 2022 Jun 25. Epub 2022 Jun 25.

The Chinese University of Hong Kong, 26451, Institute of Digestive Disease and the Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, Hong Kong, Hong Kong;

Significance: Hepatocellular carcinoma (HCC) is a liver malignancy with high mortality rate, limited treatment options and poor prognosis. Sorafenib has been the only systemic treatment option for patients with advanced HCC for more than a decade. While HCC is a typical inflammation-related tumor with distinct immunosuppressive microenvironment especially the up-regulation of immune checkpoints. Read More

Folia Morphol (Warsz) 2022 Jun 27. Epub 2022 Jun 27.

Department of Anatomical Dissection and Donation, Medical University of Lodz, Poland.

The rapid development of sciences such as genetics and molecular biology offers hope that better therapeutic methods can be developed and diagnosis and treatment made more effective. However, we must not forget that the basis for understanding the complex mechanisms of diseases and associated symptoms is knowledge of the relevant location and correlation among organs. In the present study, we focus on the clinical significance of the inferior phrenic artery. Read More

Ann Surg Oncol 2022 Jun 26. Epub 2022 Jun 26.

Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, People's Republic of China.

Background: Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer death worldwide, and the prognosis remains dismal. In this study, two pivotal factors, microvascular invasion (MVI) and vessels encapsulating tumor clusters (VETC) were preoperatively predicted simultaneously to assess prognosis.

Methods: A total of 133 HCC patients who underwent surgical resection and preoperative gadolinium ethoxybenzyl-diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) were included. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 May;47(5):588-599

Department of Intervention, Shenzhen People's Hospital, Shenzhen 518020, China.

Objectives: Patients with hepatocellular carcinoma (HCC) have poor prognosis due to lack of early diagnosis and effective treatment. Therefore, there is an urgent need to better understand the molecular mechanisms associated with HCC and to identify effective targets for early diagnosis and treatment. This study is to explore the expression and biological role of ceramide synthase 3 (CerS3) in HCC. Read More

J Lipid Res 2022 Jun 23:100248. Epub 2022 Jun 23.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

The low-density lipoprotein receptor (LDLR) mediates the hepatic uptake of circulating low-density lipoproteins (LDL), a process that modulates the development of atherosclerotic cardiovascular disease. We recently identified RAB10, encoding a small GTPase, as a positive regulator of LDL uptake in hepatocellular carcinoma cells (HuH7) in a genome-wide CRISPR screen, though the underlying molecular mechanism for this effect was unknown. We now report that RAB10 regulates hepatocyte LDL uptake by promoting the recycling of endocytosed LDLR from RAB11-positive endosomes to the plasma membrane. Read More

J Biol Chem 2022 Jun 23:102177. Epub 2022 Jun 23.

Center for Computational Biology, Indraprastha Institute of Information Technology, Delhi 110020, India; Department of Computer Science and Engineering, Indraprastha Institute of Information Technology, Delhi 110020, India; Center for Artificial Intelligence, Indraprastha Institute of Information Technology, Delhi 110020, India. Electronic address:

Cancers are caused by genomic alterations that may be inherited, induced by environmental carcinogens, or caused due to random replication errors. Post-induction of carcinogenicity, mutations further propagate and drastically alter the cancer genomes. Although a subset of driver mutations has been identified and characterized to date, most cancer-related somatic mutations are indistinguishable from germline variants or other non-cancerous somatic mutations. Read More

Liver Int 2022 Jun 26. Epub 2022 Jun 26.

Division of Gastroenterology and Hepatology, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA.

Background And Aims: Advances in hepatitis B virus (HBV) and hepatitis C virus (HCV) therapies have improved morbidity and mortality, but global disparities in viral hepatitis outcomes remain. We evaluate global trends in the impact of HBV and HCV on disability adjusted life years (DALYs).

Methods: Using data from the 2010-2019 Global Burden of Diseases Study (GBD), overall all-cause DALYs for patients with acute HBV or HCV, HBV- or HCV-related cirrhosis, and HBV- or HCV-related hepatocellular carcinoma (HCC) were calculated as the sum of years of life lost due to premature death and years lived with disability. Read More