106,669 results match your criteria Hepatocellular Carcinoma


Keratin 19-expressing hepatocellular carcinoma and small-duct type intrahepatic cholangiocarcinoma show a similar post-operative clinical course but have distinct genetic features.

Histopathology 2019 Apr 24. Epub 2019 Apr 24.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.

Aims: The present study aimed to systematically compare clinicopathological and genetic features between keratin 19 (K19)-expressing hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA).

Methods: Consecutive cases of HCC (n=430) were classified into K19 and K19 using immunohistochemistry. ICCA cases were also separated into small- (S-iCCA; n=36) and large-duct types (n=22) based on recently proposed criteria, with the former being used in the present study. Read More

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http://dx.doi.org/10.1111/his.13884DOI Listing

In vivo induction of hepatocellular carcinoma by diethylnitrosoamine and pharmacological intervention in Balb C mice using Bergenia ciliata extracts.

Braz J Biol 2019 Oct-Dec;79(4):629-638. Epub 2019 Jan 14.

Microbial Biotechnology and Medical Toxicology Laboratory, Department of Zoology, University of Azad Jammu and Kashmir, Muzaffarabad-13100, Pakistan.

Background: Hepatocellular carcinoma is the most frequent primary malignancy of liver and accounts for as many as one million deaths worldwide in a year.

Objectives: The aim of the present study was to evaluate the anti-cancerous efficiency of Bergenia ciliata rhizome against diethylnitrosoamine induced hepatocarcinogenesis in Balb C mice.

Methods: One percent diethylnitrosoamine was prepared by using 99 ml of normal saline NaCl (0. Read More

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http://dx.doi.org/10.1590/1519-6984.186565DOI Listing
January 2019

Hypo-phosphorylated CD147 promotes migration and invasion of hepatocellular carcinoma cells and predicts a poor prognosis.

Cell Oncol (Dordr) 2019 Apr 23. Epub 2019 Apr 23.

Department of Cell Biology, National Translational Science Center for Molecular Medicine, Fourth Military Medical University, Xi'an, 710032, People's Republic of China.

Purpose: CD147 is a tumor-associated antigen that plays a key regulatory role in tumor invasion and distant metastasis. However, the exact role of CD147 phosphorylation, which is deregulated during cancer progression, is unknown. Here, the effects of CD147 phosphorylation on the malignant behavior of hepatocellular carcinoma (HCC) cells and its possible underlying mechanisms are explored. Read More

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http://dx.doi.org/10.1007/s13402-019-00444-0DOI Listing

ASB3 knockdown promotes mitochondrial apoptosis via activating the interdependent cleavage of Beclin1 and caspase-8 in hepatocellular carcinoma.

Sci China Life Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, 200040, China.

Apoptosis and autophagy are distinct cellular processes that can be highly interconnected. The cross talk between the two processes is indispensable in determining the overall cell fate. Although the apoptosis-promoting effect of caspases has been demonstrated, the roles of autophagy-related proteins and even autophagy itself in regulating apoptosis remain poorly understood. Read More

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http://dx.doi.org/10.1007/s11427-018-9505-0DOI Listing
April 2019
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Deep learning for liver tumor diagnosis part I: development of a convolutional neural network classifier for multi-phasic MRI.

Eur Radiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Radiology and Biomedical Imaging, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.

Objectives: To develop and validate a proof-of-concept convolutional neural network (CNN)-based deep learning system (DLS) that classifies common hepatic lesions on multi-phasic MRI.

Methods: A custom CNN was engineered by iteratively optimizing the network architecture and training cases, finally consisting of three convolutional layers with associated rectified linear units, two maximum pooling layers, and two fully connected layers. Four hundred ninety-four hepatic lesions with typical imaging features from six categories were utilized, divided into training (n = 434) and test (n = 60) sets. Read More

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http://dx.doi.org/10.1007/s00330-019-06205-9DOI Listing
April 2019
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Current status of the combination therapy of transarterial chemoembolization and local ablation for hepatocellular carcinoma.

Authors:
Wei Li Cai-Fang Ni

Abdom Radiol (NY) 2019 Apr 23. Epub 2019 Apr 23.

Department of Interventional Radiology, First Affiliated Hospital of Soochow University, 188 Shizi Street, 215006, Suzhou, Jiangsu, People's Republic of China.

Purpose Of Review: To review the current status and ideal time interval of the combination therapy of transarterial chemoembolization (TACE) and local ablation for patients with HCCs.

Recent Findings: In recent years, local ablation has been proposed as an alternative curative treatment in the management of HCC. Additionally, many treatment options are available including TACE molecular targeted agents and immune checkpoint inhibitors. Read More

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http://link.springer.com/10.1007/s00261-019-01943-2
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http://dx.doi.org/10.1007/s00261-019-01943-2DOI Listing
April 2019
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Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma: an overview on the current state of knowledge.

Infect Agent Cancer 2019 16;14:10. Epub 2019 Apr 16.

1Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori, IRCCS - Fondazione G Pascale, Naples, Italy, Naples, Italy.

Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant . This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies showed that TQ, through the modulation of different molecular pathways, is able to induce anti-apoptotic and anti-proliferative effects in HCC, without signs of toxicity. Read More

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http://dx.doi.org/10.1186/s13027-019-0226-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469080PMC

Profile of HBV Integration in the Plasma DNA of Hepatocellular Carcinoma Patients.

Curr Genomics 2019 Jan;20(1):61-68

1Jining Medical University, Jining, Shandong272067, China; 2Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, Shandong272067, China; 3Southern University of Science and Technology, Shenzhen518055, China; 4Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen518002, China; 5Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA19104, USA; 6BGI College, University of Chinese Academy of Sciences, Shenzhen518083, China.

Background: Hepatitis B Viral (HBV) infection is one of the major causes of Hepatocellular Carcinoma (HCC). Mounting evidence had provided that the HBV integration might be a critical con-tributor of HCC carcinogenesis.

Objective And Methods: To explore the profile of HBV integration in the plasma DNA, the method of next-generation sequencing, HBV capture and bioinformatics had been employed to screen for HBV in-tegration sites in the plasma samples. Read More

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http://dx.doi.org/10.2174/1389202919666181002144336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446477PMC
January 2019

Entecavir monotherapy versus de novo combination of lamivudine and adefovir for compensated hepatitis B virus-related cirrhosis: a real-world prospective multicenter cohort study.

Infect Drug Resist 2019 1;12:745-757. Epub 2019 Apr 1.

Liver Research Centre, Beijing Friendship Hospital, Capital Medical University, Beijing, China,

Background: De novo combination of lamivudine (Lam) and adefovir (Adv) was not rarely used in clinical practice. However, head-to-head comparisons of entecavir (Etv) monotherapy with this combination in hepatitis B virus (HBV)-related compensated cirrhosis patients are unavailable. This study aimed to compare the efficacy and safety of Etv monotherapy with combination therapy in patients with HBV-related compensated liver cirrhosis. Read More

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http://dx.doi.org/10.2147/IDR.S185120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448536PMC

Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression.

Sci Rep 2019 Apr 23;9(1):6428. Epub 2019 Apr 23.

Department of Medicine, Case Western Reserve University & University Hospitals, Cleveland, Ohio, USA.

Mistletoe (Viscum album) is a type of parasitic plant reported to have anticancer activity including in hepatocellular carcinoma (HCC). However, the mechanism of mistletoe's anticancer activity, and its effectiveness in treating HCC are not fully understood. We report here that mistletoe extracts, including Fraxini (grown on ash trees) and Iscador Q and M (grown on oak and maple trees), exert strong antiproliferative activity in Hep3B cells, with median inhibitory concentrations (IC) of 0. Read More

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http://dx.doi.org/10.1038/s41598-019-41444-2DOI Listing

Promotion of growth factor signaling as a critical function of β-catenin during HCC progression.

Nat Commun 2019 Apr 23;10(1):1909. Epub 2019 Apr 23.

Children's Hospital of Philadelphia, Center for Childhood Cancer Research, Philadelphia, PA, 19104, USA.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. β-catenin is widely thought to be a major oncogene in HCC based on the frequency of mutations associated with aberrant Wnt signaling in HCC patients. Challenging this model, our data reveal that β-catenin nuclear accumulation is restricted to the late stage of the disease. Read More

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http://dx.doi.org/10.1038/s41467-019-09780-zDOI Listing

Role of Allelic Imbalance in Predicting Hepatocellular Carcinoma (HCC) Recurrence Risk After Liver Transplant.

Ann Transplant 2019 Apr 24;24:223-233. Epub 2019 Apr 24.

Department for Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and High Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.

BACKGROUND One of the most controversial problems for liver transplantation in patients affected by hepatocellular carcinoma (HCC) remains the lack of an oncologic staging system to predict cancer recurrence after liver transplantation (LT). We analyzed allelic imbalance (AI) in 19 microsatellites, and assessed the post-LT HCC recurrence risk. MATERIAL AND METHODS Seventy-one patients were included; 18 had tumor recurrence within 5 years post-transplant. Read More

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http://dx.doi.org/10.12659/AOT.913692DOI Listing

OBI-3424, a novel AKR1C3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALL.

Clin Cancer Res 2019 Apr 23. Epub 2019 Apr 23.

Leukaemia Biology Program, Children's Cancer Institute

Purpose: OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase family 1 member C3 (AKR1C3) to a potent DNA alkylating agent. OBI-3424 has entered clinical testing for hepatocellular carcinoma and castrate resistant prostate cancer, and it represents a potentially novel treatment for acute lymphoblastic leukemia (ALL).

Experimental Design: We assessed AKR1C3 expression by RNA-Seq and immunoblotting, and evaluated the in vitro cytotoxicity of OBI-3424. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0551DOI Listing

Increased multimodality treatment options has improved survival for Hepatocellular carcinoma but poor survival for biliary tract cancers remains unchanged.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Hepato-Biliary Surgery, University Hospital Aintree, Liverpool, UK.

Background: Primary hepatobiliary cancer incidence in the UK is rising and survival rates are low. Surgery is the main curative option for these cancers, but multimodality therapies are expanding. The aim of our original study was to determine trends in survival, over an 8-year period, of patients treated for primary hepatobiliary cancers at our tertiary referral Centre. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.04.002DOI Listing

Cytotoxic phenylethanoid glycosides from Digitalis davisiana Heywood: Evaluation of structure activity relationships and chemotaxonomical significance of isolated compounds.

Fitoterapia 2019 Apr 20. Epub 2019 Apr 20.

Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100, Sihhiye, Ankara, Turkey.

The phytochemical studies on the aerial parts of Digitalis davisiana Heywood led to the isolation of three undescribed phenylethanoid glycosides named as digidavisoside A (5), digidavisoside B (7), and davisoside (8), along with 9 known compounds, ferruginoside B (1), isolugrandoside (2), lugrandoside (3), maxoside (4), 3″-O-methylmaxoside (6), trans-lamiuside E (9), digiciliside B (10), p-hydroxyacetophenone (11), and chrysoeriol (12). For the first time compound 11 was reported for Digitalis genus. The chemotaxonomical significance of these compounds in Plantaginaceae family was evaluated and 3'-O-glucosyl substituted phenylethanoid glycosides 4-8 and 10 were found to be chemotaxonomically important for the family. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.04.009DOI Listing

Controversy in the Treatment of Localized Hepatocellular Carcinoma.

Int J Radiat Oncol Biol Phys 2018 Dec;102(5):1404

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.ijrobp.2018.08.042DOI Listing
December 2018

Analysis of serum Haptoglobin using glycoproteomics and lectin immunoassay in liver diseases in Hepatitis B virus infection.

Clin Chim Acta 2019 Apr 20. Epub 2019 Apr 20.

Transfusion Transmitted Diseases Department, National Institute of Immunohaematology (ICMR), 13th Floor, New Multi-storeyed Bldg, KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India. Electronic address:

Background: Hepatocellular carcinoma (HCC) due to Hepatitis B viral (HBV) infection is major cause in Asia-Pacific countries. Its early detection is of paramount importance using a marker having both sensitivity and specificity. The present study promises diagnostic and prognostic markers by the identification of site specific glycoforms on Haptoglobin (Hp) using LC-MS/MS and lectin ELISA in liver diseased conditions in HBV infection. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.072DOI Listing

Primary care provider perceptions and experiences of implementing hepatitis C virus birth cohort testing: a qualitative formative evaluation.

BMC Health Serv Res 2019 Apr 23;19(1):236. Epub 2019 Apr 23.

Center for Healthcare Organization and Implementation Research, VA Boston Healthcare System, Boston, MA, USA.

Background: In 2014, the Department of Veterans Affairs (VA) adopted a screening test policy for hepatitis C virus (HCV) in all "Baby Boomers" - those born between 1945 and 1965. About 1 in 12 Veterans were estimated to be infected with HCV yet approximately 34% of the birth cohort remained untested. Early HCV diagnosis and successful antiviral treatment decrease the risk of onward transmission, cirrhosis, hepatocellular carcinoma, liver transplant, and death. Read More

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http://dx.doi.org/10.1186/s12913-019-4043-zDOI Listing

LightCpG: a multi-view CpG sites detection on single-cell whole genome sequence data.

BMC Genomics 2019 Apr 23;20(1):306. Epub 2019 Apr 23.

School of Computer Science and Technology, College of Intelligence and Computing, Tianjin University, Tianjin, China.

Background: DNA methylation plays an important role in multiple biological processes that are closely related to human health. The study of DNA methylation can provide an insight into the mechanism behind human health and can also have a positive effect on the assessment of human health status. However, the available sequencing technology is limited by incomplete CpG coverage. Read More

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http://dx.doi.org/10.1186/s12864-019-5654-9DOI Listing

Expression tendency and prognostic value of TCF21 in hepatocellular carcinoma.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):1466-1470

a Department of Interventional Medicine , Chinese PLA General Hospital-Sixth Medical Center , Beijing , China.

Background: Transcription factor 21 (TCF21) is identified as a tumor suppressor in a variety of human tumors. The purpose of the study was to examine its expression tendency and prognostic value in hepatocellular carcinoma (HCC).

Methods: Relative expression of TCF21 mRNA in tissue samples from HCC patients and healthy volunteers were detected through quantitative real-time polymerase chain reaction (qRT-PCR) while its protein level was examined via immunohistochemistry analysis. Read More

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https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1
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http://dx.doi.org/10.1080/21691401.2019.1601102DOI Listing
December 2019
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New Concept of Hepatocellular Carcinoma Treatment with the Tumor Suppressor 'WDR76' through 'RAS' Degradation.

Authors:
Jun Yong Park

Korean J Gastroenterol 2019 Mar;73(3):190-191

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.4166/kjg.2019.73.3.190DOI Listing

Efficacy and Safety of Combined Radiofrequency Ablation with Transarterial Chemoembolization in Patients with Barcelona Clinic Liver Cancer Stage A Hepatocellular Carcinoma Ineligible for Curative Treatment.

Korean J Gastroenterol 2019 Mar;73(3):167-176

, Konkuk University School of Medicine, Seoul, Korea.

Background/aims: Surgical resection or ablation is recommended for the treatment of early hepatocellular carcinoma (HCC), whereas transarterial chemoembolization (TACE) is frequently used in early HCC ineligible for curative resection. We evaluated the clinical effects and safety of radiofrequency ablation (RFA) shortly after TACE in patients with Barcelona clinic liver cancer (BCLC) stage A HCC.

Methods: Sixty-seven BCLC stage A HCC patients who failed to achieve complete response to TACE as either a first line treatment and who subsequently received RFA at the Konkuk University Medical Center from January 2005 to December 2017 were included. Read More

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http://dx.doi.org/10.4166/kjg.2019.73.3.167DOI Listing

Curative Loco-regional Therapies for Early Hepatocellular Carcinoma: Is Combination Effective?

Authors:
Sae Hwan Lee

Korean J Gastroenterol 2019 Mar;73(3):121-123

Division of Gastroenterology, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

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http://dx.doi.org/10.4166/kjg.2019.73.3.121DOI Listing

Fine-needle aspirate of the liver showing coexistence of Schistosoma japonicum ova and hepatocellular carcinoma.

Diagn Cytopathol 2018 Aug;46(8):716-720

Department of Pathology, Loyola University Medical Center, Maywood, Illinois.

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http://dx.doi.org/10.1002/dc.23969DOI Listing

LncRNA TRERNA1 facilitates hepatocellular carcinoma metastasis by dimethylating H3K9 in the CDH1 promoter region via the recruitment of the EHMT2/SNAI1 complex.

Cell Prolif 2019 Apr 22:e12621. Epub 2019 Apr 22.

Department of Medical Genetics and Developmental Biology, Medical School of Southeast University, The Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Southeast University, Nanjing, China.

Objectives: Long non-coding RNAs (LncRNAs) play an important role in hepatocellular carcinoma development, however, as a crucial driver of hepatocellular carcinoma (HCC) metastasis, their functions in tumour metastasis remain largely unknown.

Materials And Methods: The lncRNA TRERNA1 expression levels were detected in HCC by quantitative real-time PCR (qPCR). The function of TRERNA1 was examined by wound-healing assays, transwell assays and tail vein injection experiments. Read More

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http://dx.doi.org/10.1111/cpr.12621DOI Listing

Minimally Invasive Liver Resection for Early-Stage Hepatocellular Carcinoma: Inconsistent Outcomes from Matched or Weighted Cohorts.

J Gastrointest Surg 2019 Apr 22. Epub 2019 Apr 22.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.

Background: The aim of the current study was to re-evaluate the role of minimally invasive liver resection (MILR) among patients with early-stage (stage I or II) hepatocellular carcinoma (HCC) undergoing partial hepatectomy.

Methods: A retrospective analysis of the National Cancer Database (NCDB) was conducted to identify patients with early-stage HCC who underwent partial hepatectomy in the USA from 2010 to 2013. Overall survival (OS) was compared in three cohorts: crude; stabilized inverse probability of treatment propensity score weighting (IPTW); and propensity score matching (PSM). Read More

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http://dx.doi.org/10.1007/s11605-019-04221-0DOI Listing

Treatment Patterns and Economic Burden by Lines of Therapy Among Patients with Advanced Hepatocellular Carcinoma Treated with Systemic Cancer Therapy.

J Gastrointest Cancer 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

Purpose: This study examined clinical and economic outcomes among patients with advanced hepatocellular carcinoma (HCC) treated with systemic agents by line of therapy.

Methods: Adults with ≥ 2 medical claims for primary diagnosed HCC (from January 1, 2008, through September 30, 2015) and ≥ 1 claim for systemic HCC-related therapy were identified in the IBM MarketScan® Research Databases. Continuous enrollment was required 6 months before and 1 month after diagnosis. Read More

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http://dx.doi.org/10.1007/s12029-019-00230-zDOI Listing

Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma.

Mol Ther Oncolytics 2019 Jun 27;13:22-34. Epub 2019 Mar 27.

Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing 210093, China.

In addition to direct oncolysis, oncolytic viruses (OVs) also induce antitumor immunity, also called viro-immunotherapy. Limited viral replication and immune-negative feedback are the major hurdles to effective viro-immunotherapy. In this study, we found that use of an adjuvant of fludarabine, a chemotherapeutic drug for chronic myeloid leukemia, increased the replication of Newcastle disease virus (NDV) by targeting signal transducer and activator of transcription 1 (STAT1), which led to enhanced oncolysis of hepatocellular carcinoma (HCC) cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23727705193003
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http://dx.doi.org/10.1016/j.omto.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461577PMC
June 2019
1 Read

[Viral Hepatitis B: clinical, paraclinical and evolutionary features within the Hepatogastroenterology Department at the Aristide Le Dantec Hospital: about 728 cases].

Pan Afr Med J 2018 3;31:82. Epub 2018 Oct 3.

Service d'Hépato-gastro-entérologie, Hôpital Aristide Le Dantec, Dakar, Sénégal.

Viral Hepatitis B is a major public health problem in sub-Saharan Africa accounting for approximately 65 million of chronic carriers and 56.000 deaths per year. Our study aims to investigate the epidemiological paraclinical, therapeutic and evolutionary features of viral hepatitis B in patients followed up in our Department and to describe their serological profiles. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.82.14725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461970PMC
October 2018

EpCAM- and/or NCAM-Expressing Hepatocellular Carcinoma in Which Behavior of Hepatic Progenitor Cell Marker-Positive Cells Are Followed.

Case Rep Gastroenterol 2019 Jan-Apr;13(1):118-124. Epub 2019 Mar 5.

Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Science, Niigata University, Niigata, Japan.

Hepatic progenitor cell (HPC) marker-positive hepatocellular carcinomas (HCCs) have recently been extensively analyzed, and their prognosis has been reported as poor compared to HPC marker-negative HCCs. However, previous studies have analyzed the existence of HPC marker-positive cancer cells only in primary lesions, as well as the recurrence rate and prognosis of such tumors. Here, we are the first to report the behavior of HPC marker-positive cancer cells during vascular invasion and metastasis of an HCC. Read More

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http://dx.doi.org/10.1159/000498913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465753PMC
March 2019
1 Read

Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma.

World J Gastroenterol 2019 Apr;25(14):1715-1728

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

Background: Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma (HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients. Read More

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http://dx.doi.org/10.3748/wjg.v25.i14.1715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465944PMC
April 2019
1 Read

Update on hepatocellular carcinoma: Pathologists' review.

World J Gastroenterol 2019 Apr;25(14):1653-1665

Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY 12208, United States.

Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma (HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Read More

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http://dx.doi.org/10.3748/wjg.v25.i14.1653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465943PMC

Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing.

Clin Chem 2019 Apr 22. Epub 2019 Apr 22.

Beijing Advanced Innovation Center for Genomics, College of Life Sciences, Department of General Surgery, Third Hospital, Peking University, Beijing, China;

Background: Aberrant DNA hypermethylation of CpG islands occurs frequently throughout the genome in human colorectal cancer (CRC). A genome-wide DNA hypermethylation analysis technique using circulating cell-free DNA (cfDNA) is attractive for the noninvasive early detection of CRC and discrimination between CRC and other cancer types.

Methods: We applied the methylated CpG tandem amplification and sequencing (MCTA-Seq) method, with a fully methylated molecules algorithm, to plasma samples from patients with CRC (n = 147) and controls (n = 136), as well as cancer and adjacent noncancerous tissue samples (n = 66). Read More

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http://dx.doi.org/10.1373/clinchem.2019.301804DOI Listing

Prioritization for liver transplantation using the MELD score in Chile: Inequities generated by MELD exceptions.: A collaboration between the Chilean Liver Transplant Programs, the Public Health Institute and the National Transplant Coordinator.

Ann Hepatol 2019 Apr 12. Epub 2019 Apr 12.

National Liver Transplant Coordinator, Santiago, Chile. Electronic address:

Introduction And Aim: The MELD score has been established as an efficient and rigorous prioritization system for liver transplant (LT). Our study aimed to evaluate the effectiveness of the MELD score as a system for prioritization for LT, in terms of decreasing the dropout rate in the waiting list and maintaining an adequate survival post-LT in Chile.

Materials And Methods: We analyzed the Chilean Public Health Institute liver transplant registry of candidates listed from October 15th 2011 to December 31st 2014. Read More

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http://dx.doi.org/10.1016/j.aohep.2018.11.001DOI Listing
April 2019
1 Read

A hypothesis on paradoxical privileged portal vein metastasis of hepatocellular carcinoma. Can organ evolution shed light on patterns of human pathology, and vice versa?

Med Hypotheses 2019 May 25;126:109-128. Epub 2019 Mar 25.

Arrowhead Parmaceuticals, Madison, WI 53719, USA; University of Wisconsin, Madison, WI 53705, USA; University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address:

Unlike other carcinomas, hepatocellular carcinoma (HCC) metastasizes to distant organs relatively rarely. In contrast, it routinely metastasizes to liver vasculature/liver, affecting portal veins 3-10 times more often than hepatic veins. This portal metastatic predominance is traditionally rationalized within the model of a reverse portal flow, due to accompanying liver cirrhosis. Read More

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http://dx.doi.org/10.1016/j.mehy.2019.03.019DOI Listing
May 2019
1 Read

Nonalcoholic fatty liver disease: an update on the diagnosis.

Gene Expr 2019 Apr 22. Epub 2019 Apr 22.

Institute of Model Animals of Wuhan University, Wuhan, China.

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease and a major cause of related complications such as cirrhosis and hepatocellular carcinoma (HCC). NAFLD progresses through the stages of simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and HCC. However, NAFLD usually cannot be diagnosed in a timely manner, which is largely attributed to the asymptomatic features of NAFLD patients and the lack of an effective and accurate noninvasive screening approach. Read More

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http://dx.doi.org/10.3727/105221619X15553433838609DOI Listing

Metastatic Tumors of the Sinonasal Cavity: A 15-Year Review of 17 Cases.

J Clin Med 2019 Apr 19;8(4). Epub 2019 Apr 19.

Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Extranasal cancers that metastasize to the sinonasal cavity are very rare. To date, there are only limited reports regarding this rare condition within the literature. Therefore, we retrospectively reviewed all patients diagnosed with metastatic cancer of the sinonasal tract from 2003 to 2018 at a tertiary academic medical center. Read More

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http://dx.doi.org/10.3390/jcm8040539DOI Listing

Risk Factors for Severe Liver Disease in Patients With Type 2 Diabetes.

Clin Gastroenterol Hepatol 2019 Apr 19. Epub 2019 Apr 19.

Department of Upper Gastrointestinal Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Background & Aims: Type 2 diabetes is a risk factor for development of cirrhosis and hepatocellular carcinoma. However, risk factor that identify persons with the highest risk for these outcomes are missing from unselected, population-based cohorts.

Methods: The National Diabetes Register contains data on about 90% of persons in Sweden with type 2 diabetes. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.038DOI Listing

Exposure assessment and risk characterization of aflatoxins intake through consumption of maize products in the adult populations of Serbia, Croatia and Greece.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Apr 22:1-12. Epub 2019 Apr 22.

a Department of Food Safety and Quality Management , Faculty of Agriculture, University of Belgrade , Belgrade , Republic of Serbia.

The main objective of this research was to perform an exposure assessment of aflatoxins intake through consumption of maize products in Serbia, Croatia, and Greece. Food consumption survey of maize-based products has been performed during 2017 in the three countries with at least 1,000 interviewees per country covering their dietary habits and body weight. Values for the concentration of aflatoxins were extracted from available research published in the last ten years. Read More

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http://dx.doi.org/10.1080/19440049.2019.1600748DOI Listing

Role of cyclin-dependent kinases (CDKs) in hepatocellular carcinoma: therapeutic potential of targeting CDKs signaling pathway.

Hepatol Res 2019 Apr 22. Epub 2019 Apr 22.

Precision Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

Hepatocellular carcinoma (HCC) is a common malignancy of the liver and is the second leading cause of cancer-related mortalities. Two-thirds of patients have advanced disease when diagnosed, and for these patients, treatment strategies remain limited. In addition, there is a high incidence of tumor recurrence after surgical resection with the current treatment regimens. Read More

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http://dx.doi.org/10.1111/hepr.13353DOI Listing

Pantoprazole attenuates tumorigenesis via inhibition of exosomal secretion in a rat model of hepatic precancerous lesion induced by diethylnitrosamine and 2-acetamidofluorene.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.

The present study aimed to evaluate the potential therapeutic effect of pantoprazole, a proton-pump inhibitor, on precancerous lesion (PCL) in rats. diethylnitrosamine and 2-acetylaminofluorene were used to induce PCL in rats, in vivo. The rats were treated with three doses of pantoprazole (100, 50, and 25  mg/kg; three times weekly) during the last 4 weeks of the total 10 weeks of the experiment. Read More

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http://dx.doi.org/10.1002/jcb.28757DOI Listing

The expression of long non coding RNA genes is associated with expression with polymorphisms of HULC rs7763881 and MALAT1 rs619586 in hepatocellular carcinoma and HBV Egyptian patients.

J Cell Biochem 2019 Apr 22. Epub 2019 Apr 22.

Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Long noncoding RNAs (lncRNAs), highly upregulated liver cancer (HULC), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), lncRNA-AF085935, and lncRNA-uc003wbd have been implicated in hepatocellular carcinoma (HCC). Single-nucleotide polymorphism (SNP) in HULC and MALAT1 are associated with HCC susceptibility. However, association between these SNPs and lncRNA-AF085935 and lncRNA-uc003wbd expression and their potential clinical value in differentiating HCC from both hepatitis B virus (HBV)-infected Egyptian patients and the healthy specimens have not been explored yet. Read More

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http://dx.doi.org/10.1002/jcb.28726DOI Listing
April 2019
3.263 Impact Factor

Hepatocellular carcinoma in the noncirrhotic liver: a literature review.

Eur J Gastroenterol Hepatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Hepatology, The First Hospital of Jilin University, Changchun, China.

Development of hepatocellular carcinoma (HCC) is usually preceded by chronic liver injury and ongoing liver diseases. Liver cirrhosis reflects the outcome of long-term liver injury and is associated with an increased risk of developing HCC. However, HCC also arises in individuals without cirrhosis and bears several characteristics distinct from HCC in the cirrhotic liver. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001419DOI Listing

Downregulated expression of CFHL1 is associated with unfavorable prognosis in postoperative patients with hepatocellular carcinoma.

Exp Ther Med 2019 May 29;17(5):4073-4079. Epub 2019 Mar 29.

Department of Biliary Tract Surgery, Eastern Hepatobiliary Surgery Hospital, Navy Military Medical University, Shanghai 200438, P.R. China.

Complement factor H-related protein 1 (CFHL1) was recently reported to be a potential biomarker in several types of cancer. CFHL1, however, has not been found to be of prognostic value in hepatocellular carcinoma (HCC) to date. In the present study, the expression levels of CFHL1 were evaluated in 8 pairs fresh frozen tissue samples using western blotting. Read More

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http://dx.doi.org/10.3892/etm.2019.7455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469037PMC
May 2019
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Inhibition of hepatocellular carcinoma cell proliferation, migration, and invasion by a disintegrin and metalloproteinase-17 inhibitor TNF484.

J Res Med Sci 2019 25;24:26. Epub 2019 Mar 25.

Department of Ultrasound, Chinese People's Liberation Army General Hospital, Beijing, China.

Background: The aim of this study was to test the effect of TNF484 on cell proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells.

Materials And Methods: Various doses (0, 1, 10, 50, and 100 nM) of TNF484 were applied to the HepG2 and Bel7402 cells, and cell proliferation was measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide assay after 72 h. Cell migration rate was measured using the xCELLigence system, and the cell invasion ability was examined by the three-dimensional spheroid BME cell invasion assay. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_129_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450222PMC

Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for hepatocellular carcinoma.

Cancer Cell Int 2019 11;19:90. Epub 2019 Apr 11.

1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Long noncoding RNAs (lncRNAs) can act as microRNA (miRNA) sponges to regulate protein-coding gene expression; therefore, lncRNAs are considered a major part of the competitive endogenous RNA (ceRNA) network and have attracted growing attention. The present study explored the regulatory mechanisms and functional roles of lncRNAs as ceRNAs in hepatocellular carcinoma (HCC) and their potential impact on HCC patient prognosis.

Methods: In this study, we systematically studied the expression profiles and prognostic value of lncRNA, miRNA, and mRNA from a total of 838 HCC patients from five HCC cohorts (TCGA, GSE54236, GSE76427, GSE64041 and GSE14520). Read More

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https://cancerci.biomedcentral.com/articles/10.1186/s12935-0
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http://dx.doi.org/10.1186/s12935-019-0817-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458652PMC
April 2019
1 Read

Systems biology based meth-miRNA-mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression.

Cancer Cell Int 2019 8;19:89. Epub 2019 Apr 8.

Department of Biological Sciences, National University of Medical Sciences (NUMS), Abid Majeed Road, Rawalpindi, Pakistan.

Background: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading to abnormal expression of different genes as important regulators of disease onset and progression in HCC. Here, using systems biology approaches, we aimed to integrate methylation, miRNA profiling and gene expression data into a regulatory methylation-miRNA-mRNA (meth-miRNA-mRNA) network to better understand the onset and progression of the disease. Read More

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http://dx.doi.org/10.1186/s12935-019-0804-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454777PMC

Liver Resection and Partial Liver Autotransplantation for Advanced Cholangiocarcinoma.

Niger J Surg 2019 Jan-Jun;25(1):97-100

Department of General Surgery, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.

Surgery is the only known curative treatment option for cholangiocarcinoma. liver surgery and autotransplantation are promising approaches in cases that cannot be treated by conventional methods and particularly in the presence of centrally localized liver tumors as well as tumors that invade the main vascular structures. A 53-year-old female patient presented with abdominal pain and nausea. Read More

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http://www.nigerianjsurg.com/text.asp?2019/25/1/97/253790
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http://dx.doi.org/10.4103/njs.NJS_4_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452762PMC
April 2019
1 Read

Animal models for hepatocellular carcinoma.

Biochim Biophys Acta Mol Basis Dis 2019 May 10;1865(5):993-1002. Epub 2018 Aug 10.

Centenary Institute, The University of Sydney, Newtown, New South Wales, 2042, Australia; The University of Sydney Faculty of Medicine and Health, New South Wales, 2006, Australia. Electronic address:

Hepatocellular carcinoma (HCC) represents ~90% of all cases of primary liver cancer and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Establishing appropriate animal models for HCC is required for basic and translational studies, especially the models that can recapitulate one of the human disease settings. Current animal models can be categorized as chemically-induced, genetically-engineered, xenograft, or a combination of these with each other or with a metabolic insult. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.08.009DOI Listing

Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma.

Int J Hyperthermia 2019 Apr 22:1-12. Epub 2019 Apr 22.

a Institute of Hepatobiliary Surgery, Southwest Hospital , Third Military Medical University (Army Medical University) , Chongqing , P.R. China.

Purpose: Radiofrequency ablation (RFA) is widely accepted as a curative treatment for small hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can lead to rapid local recurrence. The underlying mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.1080/02656736.2019.1600052DOI Listing