4,625 results match your criteria Hepatocellular Adenoma


Downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (Ldlrad4) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis.

J Appl Toxicol 2020 Jun 28. Epub 2020 Jun 28.

Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.

We previously found downregulation of low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4), a negative regulator of transforming growth factor (TGF)-β signaling, in glutathione S-transferase placental form (GST-P) expressing ( ) pre-neoplastic lesions produced by treatment with nongenotoxic hepatocarcinogens for up to 90 days in rats. Here, we investigated the relationship between LDLRAD4 downregulation and TGFβ signaling in nongenotoxic hepatocarcinogenesis. The transcripts of Tgfb and Hb-egf increased after ≥28 days of treatment. Read More

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http://dx.doi.org/10.1002/jat.3998DOI Listing

Ki-67 "hot spot" digital analysis is useful in the distinction of hepatic adenomas and well-differentiated hepatocellular carcinomas.

Virchows Arch 2020 Jun 25. Epub 2020 Jun 25.

Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.

This study aims to investigate the utility of digital protocols for Ki-67 immunohistochemistry quantitative analysis ("hot spot" method) in the setting of well-differentiated hepatocellular neoplasms. Resection cases of typical hepatic adenomas (HAs) (n = 40), atypical HAs (n = 9), and well-differentiated hepatocellular carcinomas (WD HCCs) (n = 56) were selected. HAs were further classified by immunohistochemistry using antibodies against liver fatty acid binding protein, glutamine synthetase, B-catenin, hepatic serum amyloid A, and C-reactive protein. Read More

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http://dx.doi.org/10.1007/s00428-020-02868-8DOI Listing

Steatohepatitis-Like Changes in Hepatocellular Adenoma.

Am J Clin Pathol 2020 Jun 20. Epub 2020 Jun 20.

Department of Pathology, Seattle.

Objectives: Our aim was to investigate the frequency of steatohepatitic morphology in hepatocellular adenoma (HCA) and correlate with its clinical parameters and risk factors underlying nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).

Methods: We examined a series of 41 liver resection specimens diagnosed with HCA for steatohepatitic changes. Background nonneoplastic liver was also evaluated. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa075DOI Listing

ASO Author Reflections: Developing Personalized Care for Hepatocellular Adenoma Based on Subtype Classification.

Ann Surg Oncol 2020 Jun 16. Epub 2020 Jun 16.

Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-020-08681-6DOI Listing

A Shifting Paradigm in Diagnosis and Management of Hepatic Adenoma.

Ann Surg Oncol 2020 Jun 15. Epub 2020 Jun 15.

Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: New insights into molecular pathogenesis of hepatocellular adenomas (HCA) have allowed sub-classification based on distinct genetic alterations and a fresh look at characterizations of natural history. Clinically, this is important in understanding risk factors for two feared complications: malignant transformation and hemorrhage.

Methods: PubMed literature search for hepatocellular adenoma over all years, excluding case reports and articles focusing on multiple adenomas or adenomatosis. Read More

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http://dx.doi.org/10.1245/s10434-020-08580-wDOI Listing

Primary hepatic neuroendocrine tumor: A case report and literature review.

Int J Surg Case Rep 2020 May 30;72:1-4. Epub 2020 May 30.

Department of Surgery, Federal University of Pernambuco, Recife, PE, Brazil. Electronic address:

Introduction: Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare, having less than 200 cases reported in the literature.

Presentation Of Case: A 51-year-old woman presenting with mild intensity sharp pain in the upper abdomen that started 4 years ago. Preoperative Magnetic Resonance Imaging (MRI) suggested hepatocellular adenoma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276381PMC

Exercise Attenuates the Transition from Fatty Liver to Steatohepatitis and Reduces Tumor Formation in Mice.

Cancers (Basel) 2020 May 29;12(6). Epub 2020 May 29.

Hepatology, Department for BioMedical Research, University of Bern, Bern 3008, Switzerland.

Non-alcoholic fatty liver disease (NAFLD) leads to steatohepatitis (NASH), fibrosis, and hepatocellular carcinoma. For sedentary patients, lifestyle interventions combining exercise and dietary changes are a cornerstone of treatment. However, the benefit of exercise alone when dietary changes have failed is uncertain. Read More

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http://dx.doi.org/10.3390/cancers12061407DOI Listing

Hepatocellular adenoma in the paediatric population: Molecular classification and clinical associations.

World J Gastroenterol 2020 May;26(19):2294-2304

Division of Pathology, Department of Paediatric Laboratory Medicine, the Hospital for Sick Children, Toronto M5G 1X8, ON, Canada.

Hepatocellular adenomas (HCAs) represent rare, benign liver tumours occurring predominantly in females taking oral contraceptives. In children, HCAs comprise less than 5% of hepatic tumours and demonstrate association with various conditions. The contemporary classification of HCAs, based on their distinctive genotypes and clinical phenotypes, includes -inactivated HCAs, -mutated HCAs, inflammatory HCAs, combined -mutated and inflammatory HCAs, sonic hedgehog-activated HCAs, and unclassified HCAs. Read More

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http://dx.doi.org/10.3748/wjg.v26.i19.2294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243640PMC
May 2020
2.369 Impact Factor

Emerging roles of autophagy in hepatic tumorigenesis and therapeutic strategies in glycogen storage disease type Ia: A review.

J Inherit Metab Dis 2020 May 31. Epub 2020 May 31.

Glycogen Storage Disease Program, Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Glycogen storage disease type Ia (GSD-Ia) is an inherited metabolic disease caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) which plays a critical role in blood glucose homeostasis by catalyzing the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of glycogenolysis and gluconeogenesis. Patients with GSD-Ia manifest life-threatening fasting hypoglycemia along with the excessive accumulation of hepatic glycogen and triglycerides which results in hepatomegaly and a risk of long-term complications such as hepatocellular adenoma and carcinoma (HCA/HCC). The etiology of HCA/HCC development in GSD-Ia, however, is unknown. Read More

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http://dx.doi.org/10.1002/jimd.12267DOI Listing
May 2020
3.365 Impact Factor

New insights in the management of Hepatocellular Adenoma.

Liver Int 2020 Jul 11;40(7):1529-1537. Epub 2020 Jun 11.

Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.

Hepatocellular adenoma (HCA) are benign liver tumours that may be complicated by haemorrhage or malignant transformation to hepatocellular carcinoma. Epidemiological data are fairly outdated, but it is likely to assume that the incidence has increased over the past decades as HCA are more often incidentally found due to the more widespread use of imaging techniques and the increased incidence of obesity. Various molecular subgroups have been described. Read More

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http://dx.doi.org/10.1111/liv.14547DOI Listing

A systematic review on the complications and management of hepatic adenomas: a call for a new approach.

Eur J Gastroenterol Hepatol 2020 May 19. Epub 2020 May 19.

Department of Gastroenterology, Eastern Health.

Hepatic adenomas are benign hepatic lesions with heterogeneous characteristics. Awareness of complications, including haemorrhage and malignant transformation, has improved alongside a concurrent rise in their detection. Monitoring and management guidelines, however, remain inconsistent. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001766DOI Listing

Gene therapy using a novel G6PC-S298C variant enhances the long-term efficacy for treating glycogen storage disease type Ia.

Biochem Biophys Res Commun 2020 Jun 16;527(3):824-830. Epub 2020 May 16.

Section on Cellular Differentiation, Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

The current phase I/II clinical trial for human glycogen storage disease type-Ia (GSD-Ia) (NCT03517085) uses a recombinant adeno-associated virus (rAAV) vector expressing a codon-optimized human glucose-6-phosphatase-α (G6Pase-α or G6PC). DNA sequence changes introduced by codon-optimization can negatively impact gene expression. We therefore generated a novel variant in which a single amino acid change, S298C, is introduced into the native human G6PC sequence. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.04.124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309276PMC

Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases.

Aging (Albany NY) 2020 May 19;12(11):10337-10358. Epub 2020 May 19.

BioCruces Health Research Institute, Barakaldo, Spain.

Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. Despite early screening programs, more than half of CRC patients are diagnosed at advanced stages. Fibroblast activation protein-α (FAP) expression in cancer-associated fibroblasts (CAFs) has been associated with a higher risk of metastases and poor survival. Read More

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http://dx.doi.org/10.18632/aging.103261DOI Listing

Over 20-Year Follow-up of Patients with Hepatic Glycogen Storage Diseases: Single-Center Experience.

Diagnostics (Basel) 2020 May 13;10(5). Epub 2020 May 13.

Department of Pediatrics, Nutrition and Metabolic Diseases, Children's Memorial Health Institute, 04-730 Warsaw, Poland.

Background: The published data on the long-term outcomes of glycogen storage disease (GSD) patients is sparse in the literature. The aim of this study was to analyze the long-term (over 20 years) follow-up of patients with hepatic types of GSD-I, III, VI, and IX-from childhood to adulthood, managed by one referral center.

Patients And Methods: Thirty adult patients with hepatic GSD were included in the study. Read More

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http://dx.doi.org/10.3390/diagnostics10050297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277974PMC

Echinococcus multilocularis: Diagnostic problem in a liver core biopsy.

Cesk Patol 2020 ;56(1):32-34

Echinococcus multilocularis causes an aggressive form of hydatidosis whose histomorphological picture is generally not well recognized. We report a case of 39-year-old women presenting with poorly circumscribed nodules in the right hepatic lobe. Owing to the clinical suspicion of focal nodular hyperplasia and hepatocellular adenoma, a core biopsy was performed. Read More

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January 2020

CT-Based Radiomics Nomogram: A Potential Tool for Differentiating Hepatocellular Adenoma From Hepatocellular Carcinoma in the Noncirrhotic Liver.

Acad Radiol 2020 May 5. Epub 2020 May 5.

Department of Radiology, the Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao 266000, Shandong, China. Electronic address:

Rationale And Objectives: To evaluate the value of a radiomics nomogram for preoperative differentiating hepatocellular adenoma (HCA) from hepatocellular carcinoma (HCC) in the noncirrhotic liver.

Materials And Methods: One hundred and thirty-one patients with HCA (n = 46) and HCC (n = 85) were divided into a training set (n = 93) and a test set (n = 38). Clinical data and CT findings were analyzed. Read More

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http://dx.doi.org/10.1016/j.acra.2020.04.027DOI Listing

Unclassified hepatocellular adenoma with histological brown pigment deposition and serum PIVKA-II level elevation: a case report.

Surg Case Rep 2020 May 7;6(1):94. Epub 2020 May 7.

Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma, 371-8511, Japan.

Background: Hepatocellular adenoma (HCA) is conventionally considered a rare benign liver tumor, but advanced studies have revealed that HCA is heterogeneous, and may include a type that is prone to malignant transformations. Differentiation between well-differentiated hepatocellular carcinoma and focal nodular hyperplasia is necessary to diagnose hepatocellular adenoma through imaging; however, the tumor marker of hepatocellular carcinoma, protein induced by vitamin K absence, or antagonist II (PIVKA-II), is rarely positive in hepatocellular adenoma.

Case Presentation: A 44-year-old woman presented to our hospital with complaints of loss of appetite and weight loss. Read More

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http://dx.doi.org/10.1186/s40792-020-00853-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205962PMC

Hepatic nodules with arterial phase hyperenhancement and washout on enhanced computed tomography/magnetic resonance imaging: how to avoid pitfalls.

Abdom Radiol (NY) 2020 May 6. Epub 2020 May 6.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhong Shan Road 2, Guangzhou, 510080, China.

This essay aimed to illustrate the various hepatic nodules that may exhibit arterial phase hyperenhancement and washout on computed tomography/magnetic resonance imaging (CT/MRI). Hepatic nodules with arterial phase hyperenhancement and washout on CT/MRI include hepatocellular carcinoma, focal nodular hyperplasia-like nodules, serum amyloid A-positive hepatocellular neoplasms, intrahepatic cholangiocarcinoma, intrahepatic bile duct adenoma, hepatoblastoma, hepatocellular adenoma, hepatic epithelioid angiomyolipoma, and metastasis including neuroendocrine and gastrointestinal stromal tumors. Understanding the imaging findings is important to ensure correct diagnosis. Read More

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http://dx.doi.org/10.1007/s00261-020-02560-0DOI Listing

Limited added value of contrast-enhanced ultrasound over B-mode for the subtyping of hepatocellular adenomas.

Eur J Radiol 2020 Jul 25;128:109027. Epub 2020 Apr 25.

Assistance Publique - Hôpitaux de Paris, Hôpitaux Universitaires Paris Nord Val de Seine, Hôpital Beaujon, Clichy, France; Université de Paris, Faculté de Médecine, Paris, France; INSERM U1149, Centre de Recherche de l'Inflammation (CRI), Paris, France. Electronic address:

Purpose: To compare the features of hepatocellular adenoma subtypes (HCAs) in B-mode and contrast-enhanced ultrasound (CEUS).

Method: Thirty-three patients (31 women [94 %] and two men [6%], median age [Q1-Q3] 43.5 years old [35-51]) with 44 pathologically proven and subtyped HCAs (including 29 inflammatory HCAs [I-HCA] and 15 HNF1-α inactivated HCAs [H-HCA]) who underwent CEUS were included. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109027DOI Listing

PLAGL2-EGFR-HIF-1/2α signaling loop promotes HCC progression and Erlotinib insensitivity.

Hepatology 2020 Apr 25. Epub 2020 Apr 25.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 211198, China.

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide hence a major public health threat. Pleomorphic adenoma gene like-2 (PLAGL2) has been reported to play a role in tumorigenesis. However, its precise function in HCC remains poorly understood. Read More

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http://dx.doi.org/10.1002/hep.31293DOI Listing

Hepatocellular carcinoma with glycogen storage disease type 1a.

Pediatr Int 2020 Jun 24;62(6):744-745. Epub 2020 Apr 24.

Division of Pediatric Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://dx.doi.org/10.1111/ped.14202DOI Listing

Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance.

Toxicology 2020 Jun 19;439:152465. Epub 2020 Apr 19.

Science Strategies LLC, Charlottesville, VA, 22092, USA.

In a 79 week bioassay the pesticide synergist piperonyl butoxide (PBO) was shown to significantly increase the incidence of hepatocellular adenoma (but not hepatocellular carcinoma) in male CD-1 mice at dietary levels of 100 and 300 mg/kg/day PBO and in female mice at a dietary level of 300 mg/kg/day. As PBO is not a genotoxic agent, a series of investigative studies were undertaken to elucidate the mode of action (MOA) for PBO-induced mouse liver tumour formation. Male CD-1 mice were fed diets to provide intakes of 0 (control), 30, 100 and 300 mg/kg/day PBO and for purposes of comparison 500 ppm sodium phenobarbital (NaPB), a known constitutive androstane receptor (CAR) activator, for 7 and 14 days. Read More

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http://dx.doi.org/10.1016/j.tox.2020.152465DOI Listing

Quantification of liver fat content in liver and primary liver lesions using triple-echo-gradient-echo MRI.

Eur Radiol 2020 Apr 22. Epub 2020 Apr 22.

Department of Diagnostic and Interventional Radiology, St-Eloi University Hospital, Montpellier, France.

Objectives: To quantify and compare the fat fraction of background liver and primary liver lesions using a triple-echo-gradient-echo sequence. M&M: This IRB-approved study included 128 consecutive patients who underwent a liver MRI for lesion characterization. Fat fraction from the whole lesion volume and the normal liver parenchyma were computed from triple-echo (consecutive in-phase, opposed-phase, in-phase echo times) sequence. Read More

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http://dx.doi.org/10.1007/s00330-020-06757-1DOI Listing

A multicentre retrospective analysis on growth of residual hepatocellular adenoma after resection.

Liver Int 2020 Apr 12. Epub 2020 Apr 12.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background & Aims: Hepatocellular adenoma (HCA) is a benign liver tumour that may require resection in select cases. The aim of this study was to the assess growth of residual HCA in the remnant liver and to advise on an evidence-based management strategy.

Method: This multicentre retrospective cohort study included all patients with HCA who underwent surgery of HCA and had residual HCA in the remnant liver. Read More

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http://dx.doi.org/10.1111/liv.14467DOI Listing

Inflammatory hepatocellular adenoma, focal nodular hyperplasia and hepatic granulomas in one single patient : possible physiopathologic explanations.

Acta Gastroenterol Belg 2020 Jan-Mar;83(1):83-85

Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles (ULB), Brussels, Belgium.

We report the case of a hepatocellular adenoma associated with focal nodular hyperplasia and hepatic granulomas in a 30-yearsold woman. This association has rarely been described before but might be explained by underlying common pathophysiologic mechanisms. In this manuscript possible links between the three entities are discussed. Read More

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Fluxametamide (Pesticides).

Authors:

Food Saf (Tokyo) 2020 Mar 27;8(1):10-11. Epub 2020 Mar 27.

FSCJ conducted a risk assessment of fluxametamide (CAS No. 928783-29-3), an isoxazoline insecticide, based on results from various studies. The data used in the assessment include the fate in animals, fate in plants, residues in crops, subacute toxicity, subacute neurotoxicity, chronic toxicity, combined chronic toxicity/carcinogenicity, carcinogenicity, two-generation reproductive toxicity, developmental toxicity, and genotoxicity. Read More

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http://dx.doi.org/10.14252/foodsafetyfscj.D-20-00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101470PMC

OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation.

Cell Rep 2020 Mar;30(12):4165-4178.e7

Department of Microbiology, Oslo University Hospital, Oslo, Norway; Department of Medical Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; Department of Laboratory Medicine, St. Olavs Hospital, Trondheim, Norway. Electronic address:

Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A) develop fatty liver. RNA sequencing of male Oxr1A liver indicates decreased growth hormone (GH) signaling, which is known to affect liver metabolism. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.02.063DOI Listing

Current concepts in ablative procedures for primary benign liver lesions: a step forward to minimize the invasiveness of treatment when deemed necessary.

Med Oncol 2020 Mar 19;37(4):31. Epub 2020 Mar 19.

Department of Morphology, Surgery and Experimental Medicine, Radiology Section, University of Ferrara, Via L. Ariosto 35, Ferrara, 44121, Italy.

With increased use of medical imaging, the incidental detection of benign solid liver tumors has become more frequent. Facing with benign disease, the indications for surgery are still object of discussion in light of the stable natural course of most lesions and obvious drawbacks of any surgical intervention; therefore, in most situations, a conservative approach is recommended, and surgery is mainly reserved for those cases with persistent or worsening symptoms, or who are at risk for complications as malignant transformation. The advent of ablative techniques has widened the range of treatment options available to these patients, presenting as a valid alternative to resection in terms of safety and efficacy in selected cases, particularly in patients who are considered poor surgical candidates and with smaller lesions. Read More

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http://dx.doi.org/10.1007/s12032-020-01355-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102179PMC

Loss of HNF1α Function Contributes to Hepatocyte Proliferation and Abnormal Cholesterol Metabolism via Downregulating miR-122: A Novel Mechanism of MODY3.

Diabetes Metab Syndr Obes 2020 2;13:627-639. Epub 2020 Mar 2.

Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center, Beijing 100044, People's Republic of China.

Purpose: Mutations in hepatocyte nuclear factor 1α (HNF1α) are the cause of maturity-onset diabetes of the young type 3 (MODY3) and involved in the development of hepatocellular adenoma and abnormal lipid metabolism. Previously, we have found that the serum microRNA (miR)-122 levels in MODY3 patients were lower than those in type 2 diabetes mellitus and healthy controls. This study aimed to investigate the mechanism of decreased miR-122 levels in patients with MODY3 and whether low levels of miR-122 mediate tumorigenesis and abnormal lipid metabolism associated with HNF1α deficiency in human hepatocytes. Read More

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http://dx.doi.org/10.2147/DMSO.S236915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060037PMC

Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus ().

Vet Sci 2020 Mar 13;7(1). Epub 2020 Mar 13.

Clinic for Birds, Small Mammals and Reptiles, Institute of Poultry, Birds, Small Mammals and Reptiles, Veterinary Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia.

In recent years, degus (), rodents native to South America, have been becoming increasingly popular as pet animals. Data about neoplastic diseases in this species are still sparse and mainly limited to single-case reports. The aim of this study was to present neoplastic and non-neoplastic proliferative changes in 16/100 pet degus examined at the Veterinary Faculty University of Ljubljana from 2010 to 2015 and to describe the clinic-pathological features of these lesions. Read More

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http://dx.doi.org/10.3390/vetsci7010032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158670PMC

Characterization of Indeterminate Liver Lesions on CT and MRI With Contrast-Enhanced Ultrasound: What Is the Evidence?

AJR Am J Roentgenol 2020 06 17;214(6):1295-1304. Epub 2020 Mar 17.

Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, 585 University Ave, Toronto, ON M5G 2N2, Canada.

CT or MRI is most commonly used for characterizing focal hepatic lesions. However, findings on CT and MRI are occasionally indeterminate. Contrast-enhanced ultrasound (CEUS), with its unique characteristics as a purely intravascular contrast agent and real-time evaluation of enhancement, is a useful next step. Read More

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http://dx.doi.org/10.2214/AJR.19.21498DOI Listing

Pituitary tumours - a large retrospective single-centre study of over 2300 cases. Experience of a tertiary reference centre.

Endokrynol Pol 2020 10;71(2):116-125. Epub 2020 Mar 10.

Department of Neurosurgery, Military Institute of Medicine, Warsaw, Poland.

Introduction: Pituitary adenomas (PAs), also known as a pituitary neuroendocrine tumours (PitNET), are usually benign tumours of the anterior lobe of the pituitary gland and account for the third most common intracranial neoplasm. The most common type of pituitary adenoma is lactotroph adenoma, in which dopamine agonists are the first-line treatment. Nevertheless, in selected cases surgery or even radiotherapy may be required. Read More

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http://dx.doi.org/10.5603/EP.a2020.0011DOI Listing

Bile duct adenoma: imaging features and radiologic-pathologic correlation.

Jpn J Radiol 2020 Jun 3;38(6):561-571. Epub 2020 Mar 3.

Department of Gastoroenterology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku, Sapporo, Hokkaido, 060-0033, Japan.

Purpose: This study aimed to reveal characteristic imaging features of bile duct adenoma (BDA) by radiologic-pathologic correlation.

Materials And Methods: We retrospectively analyzed pathological and imaging findings of seven patients with BDA.

Results: The median maximum diameter of BDA was 5. Read More

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http://dx.doi.org/10.1007/s11604-020-00938-0DOI Listing

Somatostatin Analogs in Clinical Practice: a Review.

Int J Mol Sci 2020 Feb 29;21(5). Epub 2020 Feb 29.

Department of Endocrinology, "La Paz" University Hospital. Paseo de la Castellana, 261, 28046 Madrid, Spain.

Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative to corticotropinomas, gonadotropinomas, and prolactinomas resistant to dopamine agonists. Somatostatin analogs have also shown to be useful in the treatment of other endocrine diseases (congenital hyperinsulinism, Graves' orbitopathy, diabetic retinopathy, diabetic macular edema), non-endocrine tumors (breast, colon, prostate, lung, and hepatocellular), and digestive diseases (chronic refractory diarrhea, hepatorenal polycystosis, gastrointestinal hemorrhage, dumping syndrome, and intestinal fistula). Read More

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http://dx.doi.org/10.3390/ijms21051682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084228PMC
February 2020

Hepatocellular adenomas: is there additional value in using Gd-EOB-enhanced MRI for subtype differentiation?

Eur Radiol 2020 Jun 21;30(6):3497-3506. Epub 2020 Feb 21.

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Leipzig, Leipzig, Germany.

Purpose: To differentiate subtypes of hepatocellular adenoma (HCA) based on enhancement characteristics in gadoxetic acid (Gd-EOB) magnetic resonance imaging (MRI).

Materials And Methods: Forty-eight patients with 79 histopathologically proven HCAs who underwent Gd-EOB-enhanced MRI were enrolled (standard of reference: surgical resection). Two blinded radiologists performed quantitative measurements (lesion-to-liver enhancement) and evaluated qualitative imaging features. Read More

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http://dx.doi.org/10.1007/s00330-020-06726-8DOI Listing

Multidisciplinary management of the pregnant patient in haemorrhagic shock secondary to an undiagnosed ruptured liver adenoma.

BMJ Case Rep 2020 Feb 13;13(2). Epub 2020 Feb 13.

Department of Surgery, George Washington University, Washington, DC, USA.

Management of a ruptured hepatocellular adenoma during pregnancy is a rare and potentially life-threatening entity. Few case reports have described management of the pregnant patient who presents in haemorrhagic shock secondary to a ruptured liver adenoma. A 30-year-old primigravid woman at 31 weeks pregnant presented with abdominal pain and fetal bradycardia. Read More

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http://dx.doi.org/10.1136/bcr-2019-231995DOI Listing
February 2020

Co-occurrence of multiple endocrine neoplasia type 4 and spinal neurofibromatosis: a case report.

Fam Cancer 2020 Apr;19(2):189-192

Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, A440 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Multiple Endocrine Neoplasia (MEN) type 4 is a rare genetic condition that results from variants of the CDKN1B gene and predisposes individuals to develop endocrine tumors. Spinal neurofibromatosis (SNF) is an uncommon subtype of neurofibromatosis type 1 (NF1) characterized by bilateral neurofibromas of all spinal roots. Here we report a case of the co-occurrence of these syndromes, which has not yet been described in the literature. Read More

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http://dx.doi.org/10.1007/s10689-019-00152-6DOI Listing

Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model.

Arch Toxicol 2020 03 12;94(3):927-937. Epub 2020 Feb 12.

Department of Molecular Pathology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Pregnant CD-1 mice received 200 ppm dimethylarsinic acid (DMA) in the drinking water from gestation day 8-18, and tumor formation was assessed in offspring at the age of 84 weeks. DMA elevated the incidence of lung adenocarcinoma (10.0%) and total tumors (33. Read More

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http://dx.doi.org/10.1007/s00204-020-02665-xDOI Listing

Reply to "Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia".

J Magn Reson Imaging 2020 Feb 5. Epub 2020 Feb 5.

Department of Radiology, APHP, HU Henri Mondor, Creteil, France.

Level Of Evidence: 5 TECHNICAL EFFICACY STAGE: 3 CONFLICT OF INTEREST: None.

Financial Support: None. Read More

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http://dx.doi.org/10.1002/jmri.27074DOI Listing
February 2020

State-of-the-art MR Imaging of Fat-containing Focal Lesions of the Liver.

Curr Med Imaging Rev 2019 ;15(5):435-442

Department of Radiology I, Maria Skłodowska-Curie Memorial Cancer Centre, Institute of Oncology, Ul. Roentgena 5, 02-781 Warszawa, Poland.

Background: Fat can be identified in numerous liver lesions, and usually is not a specific finding. Distinguishing between different kinds of fatty deposits is an important part of differential diagnosis. Magnetic Resonance Imaging (MRI) is superior to other imaging techniques because it allows distinguishing intracellular from macroscopic fat. Read More

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http://dx.doi.org/10.2174/1573405614666171218154838DOI Listing
January 2019

Liver contrast-enhanced sonography: computer-assisted differentiation between focal nodular hyperplasia and inflammatory hepatocellular adenoma by reference to microbubble transport patterns.

Eur Radiol 2020 May 30;30(5):2995-3003. Epub 2020 Jan 30.

CHU de Bordeaux, Service d'imagerie diagnostique et Interventionnelle Magellan/Saint André, F-33000, Bordeaux, France.

Objective: A new computer tool is proposed to distinguish between focal nodular hyperplasia (FNH) and an inflammatory hepatocellular adenoma (I-HCA) using contrast-enhanced ultrasound (CEUS). The new method was compared with the usual qualitative analysis.

Methods: The proposed tool embeds an "optical flow" algorithm, designed to mimic the human visual perception of object transport in image series, to quantitatively analyse apparent microbubble transport parameters visible on CEUS. Read More

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http://dx.doi.org/10.1007/s00330-019-06566-1DOI Listing

Outcome of Colonoscopic Screening in Potential Liver Transplant Candidates.

Transplant Proc 2020 Jan - Feb;52(1):227-232

Ain Shams University, Department of Tropical Medicine Cairo, Abbasia, Egypt; and Ain Shams Center for Organ Transplantation, Cairo, Abbasia, Egypt.

Background: Screening for neoplastic lesions is mandatory as a part of the evaluation process of potential candidates for liver transplant (LT). This work aimed at identifying the main findings in screening colonoscopy and their risk factors.

Methods: Endoscopic and pathologic findings of the biopsied lesions of 311 potential candidates for living donor liver transplant were collected and analyzed. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.10.026DOI Listing

Large size and haemorrhage are not contraindications to laparoscopic resection of hepatocellular adenoma.

ANZ J Surg 2020 Jun 26;90(6):1099-1103. Epub 2020 Jan 26.

Department of Surgery, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Background: Hepatocellular adenoma (HCA) is a hepatocyte derived neoplastic lesion with an increasing incidence and a strong association with oestrogen therapy. Laparoscopic resection has proven safe for small, non-ruptured lesions whilst its use for large adenomas (≥10 cm) and cases of haemorrhage requires further investigation.

Methods: All patients undergoing liver resection for HCA at the Royal Brisbane Hospital between January 2003 and April 2018 were analysed. Read More

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http://dx.doi.org/10.1111/ans.15702DOI Listing

Advances in molecular classification and precision oncology in hepatocellular carcinoma.

J Hepatol 2020 Feb;72(2):215-229

Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, USPC, Université Paris Descartes, Université Paris Diderot, Université Paris 13, Functional Genomics of Solid Tumors Laboratory, F-75006 Paris, France; Liver Unit, Hôpital Jean Verdier, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance-Publique Hôpitaux de Paris, Bondy, France; Unité de Formation et de Recherche Santé Médecine et Biologie Humaine, Université Paris 13, Communauté d'Universités et Etablissements Sorbonne Paris Cité, Paris, France. Electronic address:

Hepatocellular carcinoma (HCC) arises from hepatocytes through the sequential accumulation of multiple genomic and epigenomic alterations resulting from Darwinian selection. Genes from various signalling pathways such as telomere maintenance, Wnt/β-catenin, P53/cell cycle regulation, oxidative stress, epigenetic modifiers, AKT/mTOR and MAP kinase are frequently mutated in HCC. Several subclasses of HCC have been identified based on transcriptomic dysregulation and genetic alterations that are closely related to risk factors, pathological features and prognosis. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.08.017DOI Listing
February 2020

[Pathology of liver tumors].

Authors:
P Schirmacher

Internist (Berl) 2020 Feb;61(2):131-139

Pathologisches Institut, Universitätsklinik Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland.

Based on recent advances in morphological and molecular research, tissue-based diagnostics of liver tumors exhibit a substantial dynamic. New clinically relevant tumor subtypes have been defined and the diagnostic criteria have been improved; examples are the new morphomolecular classifications of hepatocellular carcinoma and adenoma as well as intrahepatic cholangiocarcinoma. Therefore, molecular pathological diagnostics are gaining relevance in the identification of tumor types and therapeutic stratification. Read More

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http://dx.doi.org/10.1007/s00108-019-00729-4DOI Listing
February 2020

Management of patients with hepatocellular adenoma: a single-institution experience.

ANZ J Surg 2020 05 13;90(5):786-790. Epub 2020 Jan 13.

Upper Gastrointestinal Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Background: Hepatocellular adenoma (HCA) is a rare benign liver tumour that may cause diagnostic and management dilemmas. This study describes the clinical and histopathological characteristics of patients who were treated for HCA in a tertiary referral hospital over a 17-year period.

Methods: A retrospective review was performed of prospectively collected data of all patients treated for HCA within the Northern Upper GI Surgical unit between 2002 and 2018. Read More

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http://dx.doi.org/10.1111/ans.15648DOI Listing

[Management of benign liver tumors].

Internist (Berl) 2020 Feb;61(2):140-146

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Benign liver tumors form a heterogeneous group. The most frequent forms include simple cysts, hemangiomas, focal nodular hyperplasia and hepatocellular adenomas. They are often incidentally detected during routine sonography. Read More

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http://dx.doi.org/10.1007/s00108-019-00736-5DOI Listing
February 2020

[Sonographic diagnostics of liver tumors].

Internist (Berl) 2020 Feb;61(2):115-122

Klinik für Gastroenterologie, Hepatologie und Endokrinologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Liver tumors are often incidentally found during ultrasound examinations. The decision on further diagnostic imaging depends on the clinical context and the appearance in B mode ultrasound. This review highlights the role of grey scale and contrast-enhanced ultrasound (CEUS) and summarizes the ultrasonographic key features of the most common benign and malignant liver tumors. Read More

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http://dx.doi.org/10.1007/s00108-019-00728-5DOI Listing
February 2020

[Radiological diagnostic workup of liver tumors].

Authors:
H-J Raatschen

Internist (Berl) 2020 Feb;61(2):123-130

Institut für Diagnostische und Interventionelle Radiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

The imaging of focal liver lesions is a common task in daily radiological routine. The objectives of diagnostic imaging are, in addition to lesion detection, the characterization of the lesion as well as the follow-up assessment after surgical or local treatment or under systemic therapy. This article presents the typical morphologies observed in computed tomography and magnetic resonance imaging of hepatocellular carcinomas and intrahepatic cholangiocarcinomas as the most important representatives of primary malignant liver tumors and juxtaposes them with benign primary liver lesions such as adenoma and focal nodular hyperplasia (FNH). Read More

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http://dx.doi.org/10.1007/s00108-019-00724-9DOI Listing
February 2020