4,471 results match your criteria Hepatocellular Adenoma


The effect of oral contraceptive pill cessation on hepatocellular adenoma diameter: a retrospective cohort study.

Liver Int 2019 Feb 18. Epub 2019 Feb 18.

University of Groningen, University Medical Center Groningen, Division of Hepatopancreatobiliary Surgery and Liver Transplantation, The Netherlands.

Background & Aims: Hepatocellular Adenomas (HCA) are rare, hormone driven, benign liver tumors. HCA >50mm are associated with hemorrhage and malignant transformation. Guidelines recommend cessation of oral contraceptive pills (OCP) for size reduction, however, it is currently unknown how HCA respond to cessation of OCP. Read More

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http://dx.doi.org/10.1111/liv.14074DOI Listing
February 2019

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
5 Reads

[Hepatocellular carcinomas and their mimics].

Authors:
H-P Fischer D Goltz

Pathologe 2019 Feb;40(1):101-118

Pathologisches Institut Koblenz, Franz-Weis-Str. 13, Koblenz, Deutschland.

High resolution cross-sectional imaging techniques means that even small, well-differentiated hepatocellular tumors can also be diagnosed with biopsy. In cirrhotic liver tissue, macroregenerative and dysplastic nodules must be discriminated from hepatocellular cancer (HCC). In non-cirrhotic liver tissue the differential diagnosis includes hepatocellular adenoma, macroregeneratory nodules, fibrolamellar carcinoma, as well as primary tumors and metastases. Read More

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http://dx.doi.org/10.1007/s00292-018-0565-0DOI Listing
February 2019
7 Reads

Microbiota and gastrointestinal cancer.

J Formos Med Assoc 2019 Jan 14. Epub 2019 Jan 14.

Departments of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. Electronic address:

Gut microbiota plays important roles in many diseases, including cancer. It may promote carcinogenesis by inducing oxidative stress, genotoxicity, host immune response disturbance, and chronic inflammation. Colorectal cancer, hepatocellular carcinoma, and gastric cancer are the major gastrointestinal tract cancers in Taiwan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183092
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http://dx.doi.org/10.1016/j.jfma.2019.01.002DOI Listing
January 2019
3 Reads

[Hepatocellular carcinoma in an inflammatory adenoma with β-catenin mutation in a patient with hepatocellular adenomatosis due to germline mutation in HNF1α].

Z Gastroenterol 2019 Jan 14;57(1):46-51. Epub 2019 Jan 14.

Institut für Pathologie, Universitätsmedizin Mainz.

Hepatocyte nuclear factor 1 α (HNF1α) mutations cause maturity-onset diabetes of the young (MODY) type 3 and are associated with hepatocellular adenomatosis. Malignant transformation of HNF1α-mutated hepatocellular adenomas is rare. We report a case of a 28-year-old man with HNF1α-inactivated adenomatosis who developed an inflammatory adenoma with β catenin mutation with malignant transformation into a well-differentiated hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1055/a-0821-7154DOI Listing
January 2019
2 Reads

Gene therapy prevents hepatic tumor initiation in murine glycogen storage disease type Ia at the tumor-developing stage.

J Inherit Metab Dis 2019 Jan 14. Epub 2019 Jan 14.

Section on Cellular Differentiation, Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Hepatocellular adenoma/carcinoma (HCA/HCC) is a long-term complication of glycogen storage disease type-Ia (GSD-Ia) which is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in gluconeogenesis. Currently, there is no therapy to address HCA/HCC in GSD-Ia. We have previously shown that a recombinant adeno-associated virus (rAAV) vector-mediated G6PC gene transfer to 2-week-old G6pc-/- mice prevents HCA development. Read More

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http://dx.doi.org/10.1002/jimd.12056DOI Listing
January 2019
1 Read

Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature.

Gastroenterology Res 2018 Dec 17;11(6):430-435. Epub 2018 Dec 17.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. Read More

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http://dx.doi.org/10.14740/gr1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306111PMC
December 2018
1 Read

Update on the pathology of liver neoplasms.

Ann Diagn Pathol 2019 Feb 12;38:126-137. Epub 2018 Oct 12.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address:

Many advances have developed in the pathology of liver tumors in the recent decade. Examples of these advances include the use of glutamine synthetase in the diagnosis of focal nodular hyperplasia, subtyping of hepatocellular adenomas using molecular and immunohistochemical methods, the unraveling of the fusion transcript between the DNAJB1 gene and the PRKACA gene in fibrolamellar carcinoma, and the more unified classification and terminology in intrahepatic bile duct tumors and their precursor lesions. Nevertheless, challenges still remain, e. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.005DOI Listing
February 2019
3 Reads

Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report.

Ann Hepatol 2018 Dec;18(1):263-268

Institute of Liver Studies, King's College Hospital, London, UK.

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7936DOI Listing
December 2018
3 Reads

Colorectal Cancer: Causes and Evidence of Chemopreventive Treatments.

Curr Pharm Biotechnol 2018 12 25. Epub 2018 Dec 25.

Department of Engineering in Biomedical Systems, Faculty of Engineering, National Autonomous University of Mexico, Exterior Circuit, University City, 04510. Mexico.

Background: Colorectal cancer (CRC) is the second and third most frequent cancer in women and men, respectively; indeed, CRC is placed as the fourth world's most deadly cancer (after lung, liver, and stomach cancer). The incidence of CRC is strongly influenced by nutrition and the high fat/high carbohydrate Western-style diet. CRC is one of the most intensively studied cancer types, partly because of its high prevalence, but also because of the existence of its precursor lesions, tubular or villous adenomas, and more recently serrated adenomas. Read More

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http://www.eurekaselect.com/168575/article
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http://dx.doi.org/10.2174/1389201020666181226112712DOI Listing
December 2018
4 Reads

Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice.

Toxicol Pathol 2018 Dec 20:192623318810200. Epub 2018 Dec 20.

1 Division of Pathology, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.

Long-term exposure to piperonyl butoxide (PBO) induces multiple nodular masses along with hepatocellular tumors in the liver of mice. The histopathological features of the nodules led to our diagnosis of nodular regenerative hepatocellular hyperplasia (NRH). However, because of the lack of data on the biological characteristics of NRH, whether this lesion is truly nonneoplastic remains unknown. Read More

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http://dx.doi.org/10.1177/0192623318810200DOI Listing
December 2018
1 Read

Evaluation of hepatic tumor portal perfusion using mesenteric angiography: A pilot study in 5 dogs.

J Vet Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Lamb Statistical Consulting, West St. Paul, Minnesota.

Background: Mesenteric angiography is a sensitive method for visualizing portal perfusion in the dog.

Objectives: To evaluate hepatic portal perfusion in dogs with incompletely resectable hepatic tumors using mesenteric angiography.

Animals: Five client-owned dogs with incompletely resectable hepatic tumors evaluated with mesenteric angiography. Read More

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http://dx.doi.org/10.1111/jvim.15395DOI Listing
December 2018
4 Reads

Value of Texture Analysis on Gadoxetic Acid-Enhanced MRI for Differentiating Hepatocellular Adenoma From Focal Nodular Hyperplasia.

AJR Am J Roentgenol 2018 Dec 17:1-9. Epub 2018 Dec 17.

1 Department of Radiology, Abdominal Imaging Division, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213.

Objective: The objective of our study was to assess the diagnostic performance of texture analysis (TA) on gadoxetic acid-enhanced MR images for differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH).

Materials And Methods: This study included 40 patients (39 women and one man) with 51 HCAs and 28 patients (27 women and one man) with 32 FNH lesions. All lesions were histologically proven with preoperative MRI performed with gadoxetic acid. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20182
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http://dx.doi.org/10.2214/AJR.18.20182DOI Listing
December 2018
10 Reads

New MRI features improve subtype classification of hepatocellular adenoma.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

CHU de Bordeaux, Service d'imagerie diagnostique et interventionnelle, Hôpital Haut-Lévêque, F-33604, Pessac, France.

Objective: MRI is crucial for the classification of hepatocellular adenomas (HCA) into subtypes. Our objective was to review and increase MRI criteria for subtype classification and define the limits.

Methods: Pathological and radiological data of 116 HCAs were retrospectively analyzed to investigate MRI features of HCA pathological subtypes. Read More

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http://dx.doi.org/10.1007/s00330-018-5784-5DOI Listing
December 2018
2 Reads

Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist.

Authors:
Alberto Quaglia

J Hepatocell Carcinoma 2018 8;5:99-108. Epub 2018 Nov 8.

Department of Cellular Pathology, Royal Free Hospital, London NW3 2QG, UK,

Histopathologists retain a critical role in the diagnosis and management of hepatocellular carcinoma (HCC). HCC arises usually but not exclusively in a background of advanced-stage chronic liver disease. The histological diagnosis of HCC poses many challenges particularly when dealing with liver biopsy specimens due to the heterogeneity of HCC and the difficulty to confirm hepatocellular differentiation in some instances. Read More

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http://dx.doi.org/10.2147/JHC.S159808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235001PMC
November 2018
9 Reads

Impact of body mass index on CT attenuation of adrenal adenoma.

Eur J Radiol 2018 Nov 2;108:184-188. Epub 2018 Oct 2.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Objective: To investigate whether lipid metabolism-related factors regulate unenhanced CT attenuation in adrenal adenoma (AA).

Materials And Methods: Thirty-six patients with surgically proven AAs were enrolled in this study. The patients' underlying diseases were the following: primary aldosteronism (n = 24), Cushing's syndrome (n = 8), subclinical Cushing's syndrome (n = 3) and non-functioning AA (n = 1). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183034
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http://dx.doi.org/10.1016/j.ejrad.2018.09.033DOI Listing
November 2018
14 Reads

Ultrasound Imaging of Hepatocellular Adenoma Using the New Histology Classification.

Ultrasound Med Biol 2019 01 3;45(1):1-10. Epub 2018 Nov 3.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

Hepatocellular adenoma is a rare benign liver tumor. Predisposing factors include hepatic storage diseases and some genetic conditions. A new histology-based classification has been proposed but to date, the corresponding ultrasound imaging features have not been reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03015629183027
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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.06.015DOI Listing
January 2019
8 Reads

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin.

Toxicol Pathol 2019 Jan 1;47(1):11-17. Epub 2018 Nov 1.

1 Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA.

A 24-month oral carcinogenicity study of permethrin was conducted by feeding male and female CD-1 mice diets containing concentrations of 0, 20, 500, and 2,000 ppm of permethrin (males) or 0, 20, 2,500, and 5,000 ppm of permethrin (females). After approximately two years on study, surviving mice were sacrificed for the evaluation of chronic toxicity and/or carcinogenicity. An expert panel of pathologists was convened as a Pathology Working Group (PWG) to review coded liver histology sections from male and female mice and to classify all liver neoplasms according to current nomenclature and diagnostic criteria guidelines. Read More

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http://dx.doi.org/10.1177/0192623318809304DOI Listing
January 2019
10 Reads
2.140 Impact Factor

Preliminary Report: Multiple Clusters of Proliferating Cells in Non-dysplastic Corrupted Colonic Crypts Underneath Conventional Adenomas.

Authors:
Carlos A Rubio

In Vivo 2018 Nov-Dec;32(6):1473-1475

Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital Stockholm, Stockholm, Sweden

Background: The finding was recently reported of clusters of colonic crypts lined with indigenous normal epithelium displaying irregular shapes underneath the adenomatous glands of conventional (tubular or villous) adenomas. These abnormal crypts were named non-dysplastic corrupted colonic crypts (NDCs). This study explored the characteristics of cell proliferation in NDCs present in a cohort of conventional adenomas. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11401
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http://dx.doi.org/10.21873/invivo.11401DOI Listing
January 2019
9 Reads

ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer.

BMC Cancer 2018 Oct 22;18(1):1020. Epub 2018 Oct 22.

Department of Geratic Surgery, Central South University, Xiangya Road 87, Changsha, Hunan, 410008, People's Republic of China.

Background: Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role in invasion and metastasis. Actin-like 6A (ACTL6A) is vital for embryogenesis and differentiation and is also critical for metastasis and EMT in hepatocellular carcinoma, as observed in our previous study. Read More

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http://dx.doi.org/10.1186/s12885-018-4931-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198485PMC
October 2018
1 Read

CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules.

J Surg Oncol 2018 Nov 12;118(6):1042-1049. Epub 2018 Oct 12.

Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York.

Background And Objectives: Hürthle cell carcinoma (HCC) is an unusual and relatively rare type of differentiated thyroid cancer. Currently, cytologic analysis of fine-needle aspiration biopsy is limited in distinguishing benign Hürthle cell neoplasms from malignant ones. The aim of this study was to determine whether differences in the expression of specific genes could differentiate HCC from benign Hürthle cell nodules by evaluating differential gene expression in Hürthle cell disease. Read More

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http://doi.wiley.com/10.1002/jso.25214
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http://dx.doi.org/10.1002/jso.25214DOI Listing
November 2018
3 Reads
3.240 Impact Factor

Liver atoll sign: Inflammatory hepatocellular adenoma.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:89

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.36_12784
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http://dx.doi.org/10.1111/1754-9485.36_12784DOI Listing
October 2018
1 Read

Contrast-enhanced ultrasound patterns of hepatocellular adenoma: an Italian multicenter experience.

J Ultrasound 2018 Oct 10. Epub 2018 Oct 10.

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of Sacred Heart, Largo A. Gemelli 8, 00168, Rome, Italy.

Purpose: Hepatocellular adenoma (HCA) is a rare benign monoclonal neoplasm, recently categorized on genetic and histopathological basis into four subtypes with different biological behaviors. Since contrast-enhanced ultrasonography (CEUS) is nowadays a well-established technique for liver nodule characterization, the aim of our study was to assess CEUS features of HCAs to identify criteria that correlate with different HCA subtypes as compared to histopathologic examination and other imaging modalities.

Methods: We retrospectively analyzed data of patients with histology-proven HCA who underwent CEUS, computed tomography or magnetic resonance imaging (MRI) in seven different Italian ultrasound units. Read More

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http://link.springer.com/10.1007/s40477-018-0322-5
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http://dx.doi.org/10.1007/s40477-018-0322-5DOI Listing
October 2018
17 Reads

Molecular classification of hepatocellular adenomas: impact on clinical practice.

Hepat Oncol 2018 Jan 9;5(1):HEP04. Epub 2018 Apr 9.

Service d'Hépatologie, Hôpital Jean Verdier, Hôpitaux universitaires Paris-Seine-Saint-Denis, Assistance publique Hôpitaux de Paris, Bondy, France.

Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10-20%) and malignant transformation into hepatocellular carcinoma (<5%). A molecular classification has been recently updated in six major subgroups, linked to risk factors, histology, imaging and clinical features: adenomas inactivated for , inflammatory adenomas, β-catenin-activated adenomas mutated in exon 3, β-catenin-activated adenomas mutated in exon 7-8, sonic hedgehog adenomas, and unclassified adenomas. Read More

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https://www.futuremedicine.com/doi/10.2217/hep-2017-0023
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http://dx.doi.org/10.2217/hep-2017-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168043PMC
January 2018
2 Reads

Risk of hepatic neoplasms in Wolf-Hirschhorn syndrome (4p-): Four new cases and review of the literature.

Am J Med Genet A 2018 Nov 5;176(11):2389-2394. Epub 2018 Oct 5.

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

Wolf-Hirschhorn syndrome (WHS) is a rare contiguous gene deletion disorder characterized by distinctive craniofacial features, prenatal/postnatal growth deficiency, intellectual disability, and seizures. Various malformations of internal organs are also seen. Neoplasia has not been documented as a typical feature of WHS. Read More

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http://doi.wiley.com/10.1002/ajmg.a.40469
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http://dx.doi.org/10.1002/ajmg.a.40469DOI Listing
November 2018
4 Reads

Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability.

Pediatr Radiol 2019 Jan 28;49(1):82-90. Epub 2018 Sep 28.

Department of Radiology, Kings College Hospital, Denmark Hill, London, SE5 9RS, UK.

Background: Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.

Objective: To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.

Materials And Methods: Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Read More

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http://link.springer.com/10.1007/s00247-018-4250-5
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http://dx.doi.org/10.1007/s00247-018-4250-5DOI Listing
January 2019
8 Reads

Evaluation of texture analysis for the differential diagnosis of focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced CT images.

Abdom Radiol (NY) 2018 Sep 28. Epub 2018 Sep 28.

Abdominal Imaging Division, Department of Radiology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Purpose: To explore the value of CT texture analysis (CTTA) for differentiation of focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA) on contrast-enhanced CT (CECT).

Methods: This is a retrospective, IRB-approved study conducted in a single institution. A search of the medical records between 2008 and 2017 revealed 48 patients with 70 HCA and 50 patients with 62 FNH. Read More

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http://dx.doi.org/10.1007/s00261-018-1788-5DOI Listing
September 2018
2 Reads

Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia.

J Magn Reson Imaging 2019 Mar 25;49(3):700-710. Epub 2018 Sep 25.

Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: Current imaging guidelines do not specify the preferred hepatobiliary contrast agent when differentiating hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH) on MRI.

Purpose: To analyze intrapatient differences in the hepatobiliary phase (HBP) after use of both gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI to differentiate HCA from FNH.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.26227DOI Listing
March 2019
4 Reads

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

Cancer Res 2018 Nov 19;78(21):6098-6106. Epub 2018 Sep 19.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, the Netherlands.

Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Here, we employ a model of epithelial-specific, heterozygous deletion by use of mice and organoids. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3600DOI Listing
November 2018
14 Reads

OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.

Liver Int 2019 Jan 8;39(1):158-167. Epub 2018 Oct 8.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Background And Aims: Hepatobiliary phase (HBP) Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) has increased the accuracy in differentiating focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA). However, the ability of this technique to distinguish HCA subtypes remains controversial. The aim of this study was to investigate the expression of hepatocyte transporters (OATPB1/B3, MRP2, MRP3) in HCA subtypes, hence to understand their MRI signal intensity on HBP Gd-EOB-DTPA-enhanced MRI. Read More

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http://doi.wiley.com/10.1111/liv.13964
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http://dx.doi.org/10.1111/liv.13964DOI Listing
January 2019
12 Reads

Snapshot summary of diagnosis and management of hepatocellular adenoma subtypes.

Clin Res Hepatol Gastroenterol 2019 Feb 10;43(1):12-19. Epub 2018 Sep 10.

Inserm, UMR1053 Bordeaux research in translational oncology, BaRITOn, université de Bordeaux, 33076 Bordeaux, France.

Hepatocellular adenomas (HCA) are rare benign hepatocellular tumors occurring mainly in women taking oral contraceptives with 2 major complications: severe bleeding and malignant transformation that can be avoided if nodules exceeding 5 cm are resected. This simple attitude has been challenged in the recent years with HCA in men, in young adolescent, in aged persons, and complications in hepatocellular adenomas below 5 cm. The discovery of specific mutations leading to specific phenotypes has modified the clinical spectrum of the disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22107401183012
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http://dx.doi.org/10.1016/j.clinre.2018.07.007DOI Listing
February 2019
2 Reads

Durable complete response with a short course of streptozotocin plus doxorubicin combination in malignant metastatic insulinoma.

J Cancer Res Ther 2018 Jul-Sep;14(5):1149-1151

Department of Medical Oncology, Diskapi Yildirim Beyazid Education and Research Hospital, Ankara, Turkey.

Due to the cytotoxic effects of old chemotherapy regimens used in the islet cell tumors, capecitabine plus temozolomide combination has now become the first choice in the treatment of malignant insulinoma (MIoma). We present this case to emphasize and remind that a durable complete response in advanced stage MIoma may be achieved with a short course of streptozotocin plus doxorubicin combination. Read More

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http://dx.doi.org/10.4103/0973-1482.188293DOI Listing
October 2018
14 Reads

Dietary exacerbation of metabolic stress leads to accelerated hepatic carcinogenesis in glycogen storage disease type Ia.

J Hepatol 2018 Nov 5;69(5):1074-1087. Epub 2018 Sep 5.

Institut National de la Santé et de la Recherche Médicale, U1213, Lyon F-69008, France; Université de Lyon, Lyon F-69008 France; Université Lyon I, Villeurbanne F-69622 France. Electronic address:

Background & Aims: Glycogen storage disease type Ia (GSDIa) is a rare genetic disease associated with glycogen accumulation in hepatocytes and steatosis. With age, most adult patients with GSDIa develop hepatocellular adenomas (HCA), which can progress to hepatocellular carcinomas (HCC). In this study, we characterized metabolic reprogramming and cellular defense alterations during tumorigenesis in the liver of hepatocyte-specific G6pc deficient (L. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278183227
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http://dx.doi.org/10.1016/j.jhep.2018.07.017DOI Listing
November 2018
32 Reads

A difficult case of β-catenin-mutated hepatocellular adenoma: a lesson for diagnosis.

Histopathology 2019 Jan 6;74(2):355-357. Epub 2018 Dec 6.

Inserm, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn, Université de Bordeaux, Bordeaux, France.

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http://doi.wiley.com/10.1111/his.13751
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http://dx.doi.org/10.1111/his.13751DOI Listing
January 2019
7 Reads

Determining the anatomical origin of canine hepatic masses by CT.

J Small Anim Pract 2018 Dec 2;59(12):752-757. Epub 2018 Sep 2.

Department of Clinical Sciences and Services, The Royal Veterinary College, North Mymms, Hertfordshire, AL9 7TA, UK.

Objectives: To identify CT features of canine hepatic masses that could be used to determine their divisional or lobar origin.

Materials And Methods: Preoperative, postcontrast CT images of 57 surgically resected hepatic masses were reviewed with respect to their size, position relative to the midline, gallbladder and portal vein, nearest recognisable hepatic lobar vein or portal vein and point of contact with the diaphragm and displacement of adjacent organs.

Results: The most prevalent histological diagnoses were hepatocellular carcinoma (n=26; 46%) and adenoma (n=10; 18%). Read More

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http://dx.doi.org/10.1111/jsap.12921DOI Listing
December 2018

Subclassification of hepatocellular adenomas: practical considerations in the implementation of the Bordeaux criteria.

Pathology 2018 Oct 24;50(6):593-599. Epub 2018 Aug 24.

Envoi Specialist Pathologists, Brisbane, Qld, Australia; Faculty of Medicine, University of Queensland, Brisbane, Qld, Australia.

Hepatocellular adenomas are benign liver lesions with a risk of rupture and malignant transformation. Various molecular subgroups have been identified which appear to have characteristic morphological and immunohistochemical features. We examined the morphology and immunohistochemical profile of a series of 121 HCA from 97 patients to identify the HCA subtypes present and determine the number at risk for malignant transformation according to the World Health Organization (WHO) criteria for hepatocellular adenomas. Read More

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http://dx.doi.org/10.1016/j.pathol.2018.05.003DOI Listing
October 2018
9 Reads

Collision of hepatocellular nodules in vascular livers: A medical challenge.

Clin Res Hepatol Gastroenterol 2018 10 23;42(5):e83-e85. Epub 2018 Aug 23.

Department of pathology, hôpital Pellegrin, CHU de Bordeaux, 33076, Bordeaux, France; U1053, université de Bordeaux, 33076, Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2017.11.001DOI Listing
October 2018

Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.

Hum Pathol 2019 Jan 17;83:1-6. Epub 2018 Aug 17.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

Mutations of Hepatocyte-Nuclear-Factor-1-Homeobox-A (HNF1A) gene and loss of Liver-Fatty-Acid-Binding-Protein (LFABP) are well documented in hepatocellular adenoma. However, the role of HNF1A mutations in hepatocellular carcinoma remains to be determined. In this study, all hepatocellular neoplasms evaluated by our institutional Memorial Sloan Kettering-Integrated Mutational Profiling of Actionable Clinical Targets assay or the Cancer Genome Atlas sequencing, and cases reported in the literature, were queried for HNF1A mutations. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365190PMC
January 2019
5 Reads
2.770 Impact Factor

Current Approaches in the Management of Hepatic Adenomas.

J Gastrointest Surg 2019 Jan 14;23(1):199-209. Epub 2018 Aug 14.

Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH, USA.

Introduction: Hepatic adenomas (HAs) are a benign and relatively rare type of liver neoplasms. We review the diagnosis, evaluation, and potential therapeutic management options for patients with HA.

Methods: A comprehensive review of the English literature was performed utilizing MEDLINE/PubMed and Web of Science databases with end of search date the 30th April of 2018. Read More

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http://dx.doi.org/10.1007/s11605-018-3917-4DOI Listing
January 2019
2 Reads
2.800 Impact Factor

Be Aware of the Patient With Benign Follicular Thyroid Lesion Histology and Rising Thyroglobulin Level.

Endocr Pract 2018 08 14;24(8):740-745. Epub 2018 Aug 14.

Objective: The accurate diagnosis of thyroid follicular/Hürthle cell tumors is challenging and a matter of controversy. We present a series of patients in whom a misclassification of follicular/Hürthle cell thyroid lesions as benign has led to devastating clinical outcomes.

Methods: The Thyroid Cancer Registry of Rabin Medical Center was screened for patients with metastatic differentiated thyroid carcinoma (DTC) who had been initially diagnosed with benign follicular lesion between 1974 and 2015 and treated with hemithyroidectomy. Read More

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http://dx.doi.org/10.4158/EP-2018-0052DOI Listing
August 2018
4 Reads

Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice.

Toxicol Res (Camb) 2017 Nov 24;6(6):795-813. Epub 2017 Aug 24.

Environmental Health Science Laboratory , Sumitomo Chemical Co. , Ltd. , 1-98 , 3-Chome , Kasugade-Naka , Konohana-ku , Osaka 554-8558 , Japan . Email: ; ; Tel: +81-66466-5322.

Phenobarbital (PB) is a nongenotoxic hepatocellular carcinogen in rodents. PB induces hepatocellular tumors by activating the constitutive androstane receptor (CAR). Some previous research has suggested the possible involvement of epigenetic regulation in PB-promoted hepatocellular tumorigenesis, but the details of its molecular mechanism are not fully understood. Read More

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http://dx.doi.org/10.1039/c7tx00163kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062386PMC
November 2017
20 Reads

Spontaneous hemoperitoneum in pregnancy caused by a hepatocellular adenoma, accompanied by fetal death.

Eur J Obstet Gynecol Reprod Biol 2018 Sep 18;228:338. Epub 2018 Jul 18.

Department of Obstetrics and Gynecology, Bordeaux University Hospital, Bordeaux, France.

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http://dx.doi.org/10.1016/j.ejogrb.2018.07.015DOI Listing
September 2018
2 Reads

Hepatocyte-specific contrast media: not so simple.

Pediatr Radiol 2018 08 4;48(9):1245-1255. Epub 2018 Aug 4.

Department of Radiology, MLC 5031, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229-3026, USA.

Hepatocyte-specific contrast media are gadolinium chelates that are taken up by hepatocytes and partially cleared via the biliary tree. The absence of lesional uptake of the contrast media in the hepatobiliary phase is a marker of either the absence of hepatocytes or of poorly functioning, neoplastic hepatocytes. Uptake of the contrast media in the hepatobiliary phase, whether equal to or greater than background liver, reflects the presence of hepatocytes but does not equate to absence of neoplasia. Read More

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http://dx.doi.org/10.1007/s00247-018-4108-xDOI Listing
August 2018
3 Reads

Clinicopathological investigation of steatohepatitic hepatocellular carcinoma: A multicenter study using immunohistochemical analysis of adenoma-related markers.

Hepatol Res 2018 Nov 15;48(12):947-955. Epub 2018 Oct 15.

Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.

Aims: Steatohepatitic hepatocellular carcinoma (SH-HCC) is a newly proposed concept, which shows histological features of steatohepatitis in HCC lesions, and it is strongly associated with metabolic syndrome (MS) and steatosis/steatohepatitis in non-cancerous lesions. Recently, a substantial number of HCC associated with MS were reported to have developed from pre-existing inflammatory hepatocellular adenoma (HCA). To elucidate the characteristic features of SH-HCC, we clinicopathologically investigated strictly diagnosed SH-HCC and non-SH-HCC (standard HCC). Read More

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http://doi.wiley.com/10.1111/hepr.13203
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http://dx.doi.org/10.1111/hepr.13203DOI Listing
November 2018
5 Reads

Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing.

PLoS One 2018 27;13(7):e0200776. Epub 2018 Jul 27.

Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Background: Hepatocellular adenomas (HCA) are benign liver tumors that may transform into hepatocellular carcinoma (HCC), but the molecular drivers of this transformation remain ill-defined. This study evaluates the molecular changes in HCA and HCC and in comparison to their adjacent non-neoplastic liver.

Methods: 11 patients with HCA and 10 patients with HCC without underlying hepatitis or cirrhosis were included in this pilot study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200776PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063411PMC
January 2019
4 Reads

Regression of hepatocellular adenoma after bariatric surgery in severe obese patients.

Liver Int 2018 Dec 10;38(12):2134-2136. Epub 2018 Aug 10.

Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, The Netherlands.

Background & Aim: Obesity and metabolic syndrome are increasingly recognized as risk factors for hepatocellular adenomas (HCA). There is still sparse evidence whether weight loss or bariatric surgery could induce HCA regression in these patients. In this brief report we describe the effect of weight loss on HCA regression in severe obese patients that had undergone bariatric surgery in our centre. Read More

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http://dx.doi.org/10.1111/liv.13934DOI Listing
December 2018
2 Reads

FBP1 promotes ovarian cancer development through the acceleration of cell cycle transition and metastasis.

Oncol Lett 2018 Aug 1;16(2):1682-1688. Epub 2018 Jun 1.

Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, P.R. China.

Epithelial ovarian cancer (EOC) is the fifth most common malignancy in women, with a 5-year mortality of >70% in North America. As the symptoms are often not observed until the cancer has spread extensively, few women are diagnosed at an early stage of disease. Large-scale gene expression analyses have identified molecular subtypes within high-grade ovarian cancer with variable survival rates and drug resistance. Read More

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http://dx.doi.org/10.3892/ol.2018.8872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036457PMC
August 2018
11 Reads

A Sling Technique for Laparoscopic Resection of Segment Seven of the Liver.

JSLS 2018 Apr-Jun;22(2)

Department of Surgery, New Jersey Medical School, Rutger's University, Newark, New Jersey.

Introduction: As the incidence of liver cancer continues to increase in the setting of cirrhosis, parenchyma-sparing liver resection is increasingly necessary. A technique is described that involves using a sling made from 1-inch-wide packing gauze to retract and rotate the liver to divide the right triangular and coronary ligaments and mobilize segment 7. The right lobe is rotated anteriorly and counterclockwise, allowing access and parenchymal transection of segment 7 under ultrasonographic guidance. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020890PMC
October 2018