4,739 results match your criteria Hepatocellular Adenoma


Hypoxia-inducible exosomes facilitate liver-tropic pre-metastatic niche in colorectal cancer.

Hepatology 2021 Jun 10. Epub 2021 Jun 10.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, China.

Background & Aims: Liver metastasis is a frequent occurrences in patients with colorectal cancer (CRC), 15%-25% of CRC patients have liver metastases at the time of initial diagnosis (1). Specifically, some regional-stage patients with mild symptoms (stage Ⅰ or II) will also advance to liver metastases rapidly, even CRC lesion in situ is resected in time. Nevertheless, the precise mechanism of liver metastasis is still unclear. Read More

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Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.

Mol Metab 2021 Jun 3:101265. Epub 2021 Jun 3.

Department of Pediatrics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. Electronic address:

Objective: Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated, GSD Ia leads to severe fasting-induced hypoglycemia. Although current intensive dietary management aims to prevent hypoglycemia, patients still experience hypoglycemic events. Read More

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A case study of glycogen storage disease type Ia presenting with multiple hepatocellular adenomas: an analysis by gadolinium ethoxybenzyl-diethylenetriamine-pentaacetic acid magnetic resonance imaging.

Quant Imaging Med Surg 2021 Jun;11(6):2785-2791

Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Glycogen storage disease type Ia (GSD Ia) is a rare disease caused by a deficiency of hepatic glucose-6-phosphatase (G6Pase). Here, we report a 17-year-old Chinese boy with GSD Ia. Clinical manifestations of the patient included hepatomegaly, growth retardation, doll face, and biochemical abnormalities, including hypoglycaemia, hyperuricaemia, and hyperlipidaemia. Read More

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Application of Immunohistochemistry in the Pathological Diagnosis of Liver Tumors.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

General Medical Education and Research Center, Teikyo University, Itabashi-ku, Tokyo 173-8605, Japan.

Although radiological diagnostics have been progressing, pathological diagnosis remains the most reliable method for diagnosing liver tumors. In some cases, definite pathological diagnosis cannot be obtained by histological evaluation alone, especially when the sample is a small biopsy; in such cases, immunohistochemical staining is very useful. Immunohistochemistry is the most frequently used technique for molecular pathological diagnosis due to its broad application, ease of performance and evaluation, and reasonable cost. Read More

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Clinicopathological correlation and post-resection outcomes of hepatic angiomyolipoma.

Ann Hepatobiliary Pancreat Surg 2021 May;25(2):215-220

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Backgrounds/aims: Angiomyolipoma is a rare neoplasm of mesenchymal origin derived from perivascular epithelioid cells. Due to rarity, hepatic angiomyolipoma (HAML) has been often misdiagnosed as hepatocellular carcinoma (HCC) or other hypervascular liver tumors based on imaging studies. This study investigated the clinicopathological correlation and post-resection outcomes of HAML. Read More

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Incidental Liver Findings on Cross-sectional Imaging.

Radiol Clin North Am 2021 Jul;59(4):569-590

Department of Radiology, University of California San Diego, UCSD Medical Center, 200 West Arbor Drive, #8756, San Diego, CA 92103, USA. Electronic address:

Hepatic incidental findings often are seen on cross-sectional imaging examinations of the chest, spine, pelvis, or other nondedicated hepatic imaging. Radiologists are tasked with appropriately triaging, which requires further evaluation, even in the setting of an otherwise limited evaluation. This article reviews common benign entities encountered on ultrasound, computed tomography, or magnetic resonance imaging, along with their characteristic imaging features. Read More

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18-F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of a Large Inflammatory-Hepatocellular Adenoma.

Indian J Nucl Med 2021 Jan-Mar;36(1):95-96. Epub 2021 Mar 4.

Department of Nuclear Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.

We report a case of an 81-year-old male evaluated for a liver space-occupying lesion. US-guided biopsy and immunohistochemistry were suggestive of hepatocellular adenoma (HCA)-inflammatory (with telangiectasia). Serial 18-F fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography scans revealed a heterogeneously enhancing hypermetabolic mass in the right lobe of the liver, remaining stable for a span of 3 years. Read More

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2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.

Pharmacol Res 2021 May 20;169:105685. Epub 2021 May 20.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 211198, China. Electronic address:

Erlotinib, an EGFR tyrosine kinase inhibitor has been introduced into cancer chemotherapy. However, the therapeutic effects of erlotinib in hepatocellular carcinoma (HCC) remain vaguely understood. Our previous study found that a hypoxia-mediated PLAGL2-EGFR-HIF-1/2α signaling loop in HCC decreased response to erlotinib. Read More

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A clinical prediction model to distinguish maturity-onset diabetes of the young from type 1 and type 2 diabetes in the Chinese population.

Endocr Pract 2021 May 12. Epub 2021 May 12.

Department of Endocrinology, Key Laboratory of Endocrinology of the Ministry of Health, Peking Union Medical Collage Hospital, Chinese Academy of Medical Science; Shuaifuyuan No.1, Dongcheng District, Beijing, 100730, China. Electronic address:

Objective: Genetic detection for the diagnosis of maturity-onset diabetes of the young (MODY) in China has low sensitivity and specificity. Better gene detection is urgently needed to distinguish testing subjects. We proposed to use numerous and weighted clinical traits as key indicators for reasonable genetic testing to predict the probability of MODY in the Chinese population. Read More

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A case of laparoscopic hepatectomy for a primary hepatic neuroendocrine tumor.

Clin J Gastroenterol 2021 Jun 15;14(3):876-880. Epub 2021 May 15.

Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan.

Neuroendocrine tumors (NETs) account for approximately 1-2% of all gastrointestinal tumors. In particular, primary hepatic NETs (PHNETs) are extremely rare. A 42-year-old female patient was given a diagnosis of liver tumor after a medical check-up with ultrasonography. Read More

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Behavior and complications of hepatocellular adenoma during pregnancy and puerperium: a retrospective study and systematic review.

HPB (Oxford) 2021 Apr 28. Epub 2021 Apr 28.

University of Groningen, University Medical Center Groningen, Department of Surgery, the Netherlands. Electronic address:

Background: Hepatocellular adenomas (HCA) are benign liver tumors at risk of hemorrhage. The influence of pregnancy on HCA growth and potential bleeding remains unclear. This study investigates HCA-associated behavior and bleeding complications during or shortly after pregnancy. Read More

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Common and Rare Histological Variants of Hepatoblastoma in Children: A Pathological Diagnosis and Review of the Literature.

Gastrointest Tumors 2021 Apr 4;8(2):41-46. Epub 2021 Feb 4.

Department of Radiology, All India Institute of Medical Sciences, Jodhpur, India.

Hepatoblastoma (HB) is a rare tumor, but it is the most common primary liver malignancy in children and comprised of approximately 1% of all pediatric malignancies. Mostly, this tumor is sporadic in nature but can show a syndrome association. Upregulation in Wnt/β-catenin pathway can be there in 70-80% cases of HB. Read More

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[A Case of Metachronous Quintuple Cancer Involving the Stomach, Rectum, Colon, Liver and Prostate].

Gan To Kagaku Ryoho 2021 Apr;48(4):608-611

Dept. of Surgery, Kansai Rosai Hospital.

Advances and improvements in cancer diagnosis and treatment have made it possible to find multiple primary cancers. We report here a rare case of metachronous quintuple cancer involving the stomach, rectum, colon, liver and prostate. An 80s‒ year‒old male was referred to our hospital with abnormality on upper GI series. Read More

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Hepatocellular Adenoma and Focal Nodular Hyperplasia.

Authors:
Taofic Mounajjed

Clin Liver Dis (Hoboken) 2021 Apr 1;17(4):244-248. Epub 2021 May 1.

Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN.

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Hepatocellular adenoma initially diagnosed as hepatocellular carcinoma with resistance to proton beam radiotherapy - A case report.

Int J Surg Case Rep 2021 May 3;83:105955. Epub 2021 May 3.

Department of Surgery, Kurume University School of Medicine, Kurume, Japan.

Introduction And Importance: Hepatocellular adenoma (HCA) is a rare liver tumor. We report a case of a radio-resistant liver tumor that was removed surgically and found to be HCA.

Case Presentation: A 37-year-old Japanese man was incidentally diagnosed with a liver tumor. Read More

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Focal nodular hyperplasia mimicking hepatocellular adenoma and carcinoma in two cases.

Drug Discov Ther 2021 May 29;15(2):112-117. Epub 2021 Apr 29.

Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang, China.

Focal nodular hyperplasia (FNH) is a solid benign tumor of the liver, predominantly in young women. A correct diagnosis of FNH is essential for making appropriate clinical decisions and avoiding unnecessary liver resection. Herein, we reported that two male cases with FNH, who initially presented with persistent abdominal discomfort, were misdiagnosed with hepatocellular adenoma (HCA) and hepatocellular carcinoma (HCC) on contrast-enhanced magnetic resonance imaging and computed tomography scans, respectively. Read More

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Liver pseudolymphoma (reactive lymphoid hyperplasia): Difficulty in radiological and pathological diagnosis.

Curr Med Imaging 2021 May 4. Epub 2021 May 4.

NECMETTİN ERBAKAN ÜNİVERSİTESİ MERAM TIP FAKÜLTESİ, Turkey.

Pseudolymphoma of the liver (reactive lymphoid hyperplasia) (RLH) is a rare condition. It is usually asymptomatic and detected incidentally on radiological imaging. Imaging features are similar to hepatic adenoma, hepatocellular carcinoma, cholangiocarcinoma, and malignant lymphoma and are not specific for pseudolymphoma of the liver. Read More

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Value of discrepancy of the central scar-like structure between dynamic CT and gadoxetate disodium-enhanced MRI in differentiation of focal nodular hyperplasia and hepatocellular adenoma.

Eur J Radiol 2021 Jun 22;139:109730. Epub 2021 Apr 22.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

Purpose: To identify the value of discrepancies in the central scar (CS)-like structure between dynamic CT and gadoxetate disodium-enhanced MRI for differentiating FNH from HCA.

Methods: This retrospective study included 113 patients with pathologically-diagnosed FNH (n = 80) or HCA (n = 37). CS-like structures were evaluated on arterial phase (AP) CT and hepatobiliary phase (HBP) MRI. Read More

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The strength of cytomorphology and efficacy of immuno-cytochemistry in distinguishing hepatocellular carcinoma from its mimics on fine-needle aspiration cytology.

Diagn Cytopathol 2021 Jul 30;49(7):864-875. Epub 2021 Apr 30.

Department of Radio-diagnosis, JIPMER, Puducherry, India.

Background: Cytomorphologic distinction of hepatocellular carcinoma (HCC) from its mimics on fine-needle aspiration cytology (FNAC) is often problematic. The present study evaluates the strength of cytomorphology and the utility of an immuno-panel of arginase-1, glypican-3, HepPar-1, thyroid transcription factor (TTF-1) and CK-19 in resolving this diagnostic issue.

Methods: FNAC features of 71 nodular hepatic lesions were studied with an immunocyto/ histochemical (ICC/IHC) panel of arginase-1, glypican-3, HepPar-1, TTF-1 taking 10% positivity as "cut-off. Read More

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Mixed neuroendocrine-non-neuroendocrine neoplasm with squamous cell carcinoma covered by tubulovillous adenoma in the rectum.

Clin J Gastroenterol 2021 Apr 27. Epub 2021 Apr 27.

Department of Surgery, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

A variety of histologies is often mixed in neuroendocrine carcinoma (NEC) called mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). However, tumors consisting of both large-cell NEC and squamous cell carcinoma (SCC) are rare. NEC of the large intestine is aggressive; however, an ideal treatment strategy has not been established. Read More

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A Multicenter, 10-Year Experience With Hepatocellular Adenoma: Risk Factors and Disease Course.

Am Surg 2021 Apr 16:31348211011084. Epub 2021 Apr 16.

Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.

Background: Management of hepatocellular adenoma (HA) is marked by a paucity of recent studies. Long-term follow-up data from an equal access health care system may facilitate our understanding of the natural disease course of HA and identify modifiable risk factors.

Methods: A multi-institutional, retrospective review of patients with HA from 2008-2017 was performed. Read More

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Magnetic resonance imaging of pediatric liver tumors.

Pediatr Radiol 2021 Apr 14. Epub 2021 Apr 14.

Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Liver tumors in children can be benign or malignant. Although several clinical factors are important in the evaluation of these lesions, MRI is particularly important for lesion characterization and tumor staging. In children, use of a hepatobiliary contrast agent is recommended to evaluate a known or suspected liver lesion. Read More

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The HIV reverse transcriptase Tenofovir suppressed DMH/HFD-induced colorectal cancer in Wistar rats.

Fundam Clin Pharmacol 2021 Apr 8. Epub 2021 Apr 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Colon rectal cancer (CRC) is the second commonest malignancy in developed countries and a significant cause of mortality. Tenofovir reportedly reduces the risk of hepatocellular carcinoma and interferes with cell cycle and cell proliferation. The current study investigated the potential antitumor effect of tenofovir against experimentally induced CRC. Read More

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Hepatocellular adenomas: recent updates.

J Pathol Transl Med 2021 May 7;55(3):171-180. Epub 2021 Apr 7.

Department of Pathology, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea.

Hepatocellular adenoma (HCA) is a heterogeneous entity, from both the histomorphological and molecular aspects, and the resultant subclassification has brought a strong translational impact for both pathologists and clinicians. In this review, we provide an overview of the recent updates on HCA from the pathologists' perspective and discuss several practical issues and pitfalls that may be useful for diagnostic practice. Read More

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Management and outcome of paediatric testicular tumours - A 20 year experience.

J Pediatr Surg 2021 Mar 5. Epub 2021 Mar 5.

Department of Paediatric Surgery, Alder Hey Children's Hospital NHS Foundation Trust, School Of Health And Life Science, University of Liverpool, United Kingdom.

Objective: To report a 20-year experience highlighting management and outcome(s) of paediatric testicular tumours.

Patients And Methods: All males (< 19 years) with an index diagnosis of testicular tumours during the era(s) 1998-2018 in North West England were identified. Data were collected regarding age at diagnosis, disease stage, surgical operations, tumour biology and outcome(s). Read More

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Long-term complete remission of large hepatocellular adenoma after bariatric surgery.

Obes Res Clin Pract 2021 May-Jun;15(3):300-302. Epub 2021 Mar 23.

Bariatric and Metabolic Surgery Unit, Discipline of Digestive Surgery, University of Sao Paulo Medical School, Sao Paulo, Brazil. Electronic address:

We report the case of an obese woman with a large hepatocellular adenoma (HCA) of 8.0 cm in diameter, followed for 5 years after Roux-en-Y Gastric Bypass, with a complete radiologic remission of the liver mass. Four other cases have been published with HCA regression after bariatric surgery, but none with long-term follow-up. Read More

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Hemorrhage and Rupture of an Unusual Benign Liver Lesion in Pregnancy: A Case Report.

J Clin Exp Hepatol 2021 Mar-Apr;11(2):260-263. Epub 2020 Jul 25.

Departments of Radiodiagnosis, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Liver rupture in pregnancy is an acute condition with significant risk to the mother and fetus. It is known to occur with tumors such as hepatic adenoma, infective causes such as abscess, granulomatous diseases, and parasitic infections, and rarely spontaneously. Most of these conditions have overlapping clinicoradiological findings, almost always requiring histopathological confirmation. Read More

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Imaging, Pathology, and Immune Correlates in the Woodchuck Hepatic Tumor Model.

J Hepatocell Carcinoma 2021 9;8:71-83. Epub 2021 Mar 9.

Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA.

Background: Woodchucks chronically infected with woodchuck hepatitis virus (WHV), which resembles human hepatitis B virus, develop spontaneous hepatic tumors and may be an important biological and immunological model for human HCC. Nonetheless, this model requires further validation to fully realize its translational potential.

Methods: Woodchucks infected at birth with WHV that had developed HCC (n=12) were studied. Read More

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