4,491 results match your criteria Hepatocellular Adenoma


Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells.

Braz J Med Biol Res 2019 15;52(4):e7728. Epub 2019 Apr 15.

Department of Pain Clinic, The First Affiliated Hospital of Xiamen University, Fujian Medical University, Xiamen, Fujian, China.

Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, as well as the underlying potential mechanisms. Cell transfection and qRT-PCR were used to change and measure the expression levels of HULC, miR-130b, and FOXM1. Read More

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http://dx.doi.org/10.1590/1414-431X20197728DOI Listing

MRI for characterization of benign hepatocellular tumors on hepatobiliary phase: the added value of in-phase imaging and lesion-to-liver visual signal intensity ratio.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastrointestinal Imaging, Lille University Hospital, Rue Michel Polonovski, 59037, Lille Cedex, France.

Objectives: To evaluate the lesion-to-liver visual signal intensity ratio (SIR) before and at the hepatobiliary phase MRI (HBP-MRI) after gadobenate dimeglumine (Gd-BOPTA) injection, using several T1-weighted images (T1-WI), for the characterization of benign hepatocellular lesions.

Methods: Patients with histologically proven focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA), who underwent Gd-BOPTA-enhanced HBP-MRI from 2009 to 2017, were retrospectively identified. The lesion-to-liver SIR was visually assessed by two radiologists on HBP (post-HBP analysis) and compared with that of unenhanced sequences (pre/post-HBP analysis) on T1-WI in-phase (T1-IP), out-of-phase (T1-OP), and fat suppression (T1-FS). Read More

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http://dx.doi.org/10.1007/s00330-019-06210-yDOI Listing

Hepatocellular adenomas: one step beyond.

Gut 2019 Apr 9. Epub 2019 Apr 9.

AMMICa, CNRS-UMS 3655 and INSERM-US23, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1136/gutjnl-2019-318299DOI Listing

Hepatic disorders associated with exogenous sex steroids: MR imaging findings.

Abdom Radiol (NY) 2019 Apr 6. Epub 2019 Apr 6.

Monash Imaging, Monash Health, Melbourne, Australia.

Objective: To describe the MRI findings of the effects of exogenous sex steroids on the liver.

Findings: Estrogens, progesterone and synthetic testosterone are exogenous sex steroids that may result in a variety of liver diseases, including tumour formation and vascular disorders. These hormones are mainly administered in the form of the oral contraceptive pill (OCP) and anabolic steroids. Read More

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http://dx.doi.org/10.1007/s00261-019-01941-4DOI Listing
April 2019
1 Read

Iso- or hyperintensity of hepatocellular adenomas on hepatobiliary phase does not always correspond to hepatospecific contrast-agent uptake: importance for tumor subtyping.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Department of Radiology, APHP, HU Henri Mondor, Creteil, Val-de-Marne, France.

Purpose: This study was conducted in order to evaluate if iso- or hyperintensity of HCAs on HBP is systematically related to a high uptake of hepatospecific contrast agent, using a quantitative approach.

Methods: This bicentric retrospective study included all patients with histologically confirmed and subtyped HCA from 2009 to 2017 who underwent MRI with HBP after Gd-BOPTA injection and who showed iso- or hyperintensity on HBP. The signal intensity of tumors on pre- and postcontrast images and the presence of hepatic steatosis were noted. Read More

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http://dx.doi.org/10.1007/s00330-019-06150-7DOI Listing
April 2019
3 Reads

Impact of open and minimally invasive resection of symptomatic solid benign liver tumours on symptoms and quality of life: a systematic review.

HPB (Oxford) 2019 Mar 27. Epub 2019 Mar 27.

Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, the Netherlands.

Background: The value of open and minimally invasive liver resection for symptomatic solid benign liver tumours (BLT) such as hepatocellular adenoma, focal nodular hyperplasia and haemangioma is being debated. A systematic review on symptom relief, quality of life (QoL) and surgical outcome after both open and minimally invasive surgery for solid BLT is currently lacking.

Methods: A systematic search in PubMed and EMBASE was performed according to the PRISMA guidelines (January 1985-April 2018). Read More

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http://dx.doi.org/10.1016/j.hpb.2019.02.022DOI Listing
March 2019
1 Read

Development and Validation of a Model to Predict Regression of Large Size Hepatocellular Adenoma.

Am J Gastroenterol 2019 Mar 27. Epub 2019 Mar 27.

Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Introduction: Surgery is advocated in hepatocellular adenomas (HCA) >5 cm that do not regress to <5 cm after 6-12 months. The aim of this study was to develop a model for these patients, estimating the probability of HCA regression to <5 cm at 1 and 2 years follow-up.

Methods: Data were derived from a multicenter retrospective cohort of female patients diagnosed with HCA >5 cm at first follow-up. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000182DOI Listing
March 2019
1 Read

Repeat surgery in HNF1alpha-inactivated adenomatosis.

Clin Res Hepatol Gastroenterol 2019 Mar 19. Epub 2019 Mar 19.

Inserm, UMR1053 Bordeaux research in translational oncology, université de Bordeaux, Bariton, 33076 Bordeaux, France.

Background And Aims: Stopping oral contraceptives following nodule detection usually prevents further hepatocellular growth (HCA); rare cases of growth have been reported after surgery. The aim of the study was to review our resected HCA cases and their outcomes and more specifically, growth.

Methods: We retrieved all HCA cases that required a second intervention and HCA growth cases of none resected HCA after resection of one or several HCAs. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.11.001DOI Listing
March 2019
1 Read

gene rearrangement: a powerful driver of β-catenin activation in liver tumours.

Gut 2019 Feb 2. Epub 2019 Feb 2.

Institute of Pathology, UniversitatsKlinikum Heidelberg, Heidelberg, Germany.

Objective: We aimed at the identification of genetic alterations that may functionally substitute for mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC).

Design: Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational status of the gene was determined in ß-catenin-activated HCA (b-HCA) and HCC with at least moderate nuclear CTNNB1 accumulation. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317632DOI Listing
February 2019
2 Reads

Hepatic CYP1A2 activity in liver tumors and the implications for preoperative volume-function analysis.

Am J Physiol Gastrointest Liver Physiol 2019 Mar 14. Epub 2019 Mar 14.

Department of General, Visceral- and Transplantation Surgery, Charité - Universitätsmedizin Berlin.

Dynamic liver function assessment by the C-methacetin maximal liver function capacity (LiMAx) test reflects the overall hepatic CYP1A2 activity. One proven strategy for preoperative risk assessement in liver surgery includes the combined assessment of the dynamic liver function by the LiMAx test, the volumetric analysis of the liver and calculation of future liver remnant function. This so-called volume-function analysis assumes that the remaining CYP1A2 activity in any tumor lesion is zero. Read More

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http://dx.doi.org/10.1152/ajpgi.00335.2018DOI Listing
March 2019
1 Read

Benign liver tumors

Rev Prat 2018 12;68(10):1119-1124

Service d'hépatologie.

Benign liver tumors diagnosis. Benign liver tumors are rare events that affect mostly young women. Hepatic hemangioma and focal nodular hyperplasia are not related to oral contraceptions, nor associated with complications, and consequently should not either be treated or followed-up. Read More

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December 2018
2 Reads

Surgical indications for focal nodular hyperplasia of the liver: Single-center experience of 48 adult cases.

Ann Hepatobiliary Pancreat Surg 2019 Feb 28;23(1):8-12. Epub 2019 Feb 28.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Backgrounds/aims: Focal nodular hyperplasia (FNH) is one of the most common benign tumors of the liver. There is still a lack of evidence on surgical indications for FNH. This study intended to analyze the surgical indications for FNH. Read More

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http://dx.doi.org/10.14701/ahbps.2019.23.1.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405369PMC
February 2019
2 Reads

Identification of key challenges in liver pathology: data from a multicenter study of extramural consults.

Hum Pathol 2019 Mar 8. Epub 2019 Mar 8.

Department of Pathology, University of Washington Medical Center, Seattle, WA, USA.

Extramural consultation for challenging pathology cases is an important part of patient care. The specific reasons why liver cases are submitted in consultation are poorly understood. To study patterns in extramural consultation, data were gathered from 1360 liver/GI/pancreatobiliary consults submitted to 7 academic centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177193003
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http://dx.doi.org/10.1016/j.humpath.2019.03.001DOI Listing
March 2019
5 Reads

A case of hepatocellular carcinoma mimicking hepatic adenoma.

Ann Ital Chir 2019 Feb 26;8. Epub 2019 Feb 26.

Hepatocellular adenomas (HA) are benign naturally occurring masses that are rarely reported, and rarely reaching tumor size up to 30 cm. Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and usually caused by cirrhosis and more commonly reported tumors in males. It has been reported that presentations may occur with masses that are often less than 5 cm or rarely more than 10 cm. Read More

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February 2019
1 Read

promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1.

EMBO Rep 2019 Apr 4;20(4). Epub 2019 Mar 4.

Division of Periodontics, College of Dental Medicine, Columbia University, New York, NY, USA

, a Gram-negative oral anaerobe, is a significant contributor to colorectal cancer. Using an cancer progression model, we discover that stimulates the growth of colorectal cancer cells without affecting the pre-cancerous adenoma cells. Annexin A1, a previously unrecognized modulator of Wnt/β-catenin signaling, is a key component through which exerts its stimulatory effect. Read More

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http://dx.doi.org/10.15252/embr.201847638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446206PMC
April 2019
9.055 Impact Factor

Two Cases of Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males.

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Department of Clinical Laboratory Medicine, Kurume University Hospital, Japan.

Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant transformation, they underwent surgical resection. Read More

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http://dx.doi.org/10.2169/internalmedicine.1958-18DOI Listing
February 2019
1 Read

Inflammatory hepatocellular adenoma in a patient with Turner's syndrome: A case report.

Int J Surg Case Rep 2019 15;56:5-9. Epub 2019 Feb 15.

Department of Gastroenterology Surgery, Tokyo Women's Medical University, Japan.

Introduction: Hepatocellular adenoma (HCA) is a rare benign tumor and is related to the use of an oral contraceptive pill. Turner's syndrome requires various hormone replacement therapies, including the pill which is used as a female hormone replacement therapy. Herein we report a case of Turner's syndrome with HCA treated by liver segmentectomy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389595PMC
February 2019
2 Reads

Utilization of spectrins βI and βIII in diagnosis of hepatocellular carcinoma.

Ann Diagn Pathol 2019 Feb 15;39:86-91. Epub 2019 Feb 15.

Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, United States of America. Electronic address:

Spectrins are a group of cytoskeletal proteins which participate in many important cellular functions. It has been suggested that loss of spectrin isoforms may be associated with tumorigenesis of lymphoma, leukemia, gastric cancer and hepatocellular carcinoma (HCC). We recently reported that βI spectrin expression was present in normal hepatocytes but lost in HCC cells, which suggested that spectrins may be helpful markers in diagnosis of HCC. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.009DOI Listing
February 2019
3 Reads

FXR Regulates Intestinal Cancer Stem Cell Proliferation.

Cell 2019 Feb;176(5):1098-1112.e18

Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5) cancer stem cells and promote an adenoma-to-adenocarcinoma progression. Mechanistically, we show that BAs that antagonize intestinal farnesoid X receptor (FXR) function, including tauro-β-muricholic acid (T-βMCA) and deoxycholic acid (DCA), induce proliferation and DNA damage in Lgr5 cells. Read More

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http://dx.doi.org/10.1016/j.cell.2019.01.036DOI Listing
February 2019
1 Read
32.242 Impact Factor

The effect of oral contraceptive pill cessation on hepatocellular adenoma diameter: A retrospective cohort study.

Liver Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Hepatopancreatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background & Aims: Hepatocellular adenomas (HCA) are rare, hormone-driven, benign liver tumours. HCA >50 mm are associated with haemorrhage and malignant transformation. Guidelines recommend cessation of oral contraceptive pills (OCP) for size reduction; however, it is currently unknown how HCA respond to cessation of OCP. Read More

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http://dx.doi.org/10.1111/liv.14074DOI Listing
February 2019
4 Reads

Acromegaly associated with GIST, non-small cell lung cancer, clear cell renal cancer, myeloma multiplex, medulla oblongata tumor, adrenal adenoma and follicular thyroid nodules.

Endokrynol Pol 2019 Feb 11. Epub 2019 Feb 11.

Dept. of Endocrinology, Diabetes and Isotope Therapy, Medical University Wroclaw, Pasteura 4, 50-367 Wrocłąw, Poland.

Background: Acromegaly is associated with increased growth hormone (GH) and insulin-like growth factor-I (IGF-I) secretion which may support tumor development and growth.

Case Presentation: A 68-year old woman was diagnosed with acromegaly due to typical clinical and hormonal characteristics. While a contrast-enhanced MRI at diagnosis did not reveal a pituitary adenoma, a 5 mm lesion was identified on repeat scanning 13 months later. Read More

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http://dx.doi.org/10.5603/EP.a2019.0005DOI Listing
February 2019
6 Reads

[Hepatocellular carcinomas and their mimics].

Authors:
H-P Fischer D Goltz

Pathologe 2019 Feb;40(1):101-118

Pathologisches Institut Koblenz, Franz-Weis-Str. 13, Koblenz, Deutschland.

High resolution cross-sectional imaging techniques means that even small, well-differentiated hepatocellular tumors can also be diagnosed with biopsy. In cirrhotic liver tissue, macroregenerative and dysplastic nodules must be discriminated from hepatocellular cancer (HCC). In non-cirrhotic liver tissue the differential diagnosis includes hepatocellular adenoma, macroregeneratory nodules, fibrolamellar carcinoma, as well as primary tumors and metastases. Read More

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http://dx.doi.org/10.1007/s00292-018-0565-0DOI Listing
February 2019
9 Reads

Microbiota and gastrointestinal cancer.

J Formos Med Assoc 2019 Mar 14;118 Suppl 1:S32-S41. Epub 2019 Jan 14.

Departments of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. Electronic address:

Gut microbiota plays important roles in many diseases, including cancer. It may promote carcinogenesis by inducing oxidative stress, genotoxicity, host immune response disturbance, and chronic inflammation. Colorectal cancer, hepatocellular carcinoma, and gastric cancer are the major gastrointestinal tract cancers in Taiwan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09296646183092
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http://dx.doi.org/10.1016/j.jfma.2019.01.002DOI Listing
March 2019
6 Reads

[Hepatocellular carcinoma in an inflammatory adenoma with β-catenin mutation in a patient with hepatocellular adenomatosis due to germline mutation in HNF1α].

Z Gastroenterol 2019 Jan 14;57(1):46-51. Epub 2019 Jan 14.

Institut für Pathologie, Universitätsmedizin Mainz.

Hepatocyte nuclear factor 1 α (HNF1α) mutations cause maturity-onset diabetes of the young (MODY) type 3 and are associated with hepatocellular adenomatosis. Malignant transformation of HNF1α-mutated hepatocellular adenomas is rare. We report a case of a 28-year-old man with HNF1α-inactivated adenomatosis who developed an inflammatory adenoma with β catenin mutation with malignant transformation into a well-differentiated hepatocellular carcinoma (HCC). Read More

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http://dx.doi.org/10.1055/a-0821-7154DOI Listing
January 2019
4 Reads

Gene therapy prevents hepatic tumor initiation in murine glycogen storage disease type Ia at the tumor-developing stage.

J Inherit Metab Dis 2019 Jan 14. Epub 2019 Jan 14.

Section on Cellular Differentiation, Division of Translational Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.

Hepatocellular adenoma/carcinoma (HCA/HCC) is a long-term complication of glycogen storage disease type-Ia (GSD-Ia), which is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in gluconeogenesis. Currently, there is no therapy to address HCA/HCC in GSD-Ia. We have previously shown that a recombinant adeno-associated virus (rAAV) vector-mediated G6PC gene transfer to 2-week-old G6pc-/- mice prevents HCA development. Read More

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http://dx.doi.org/10.1002/jimd.12056DOI Listing
January 2019
3 Reads

Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature.

Gastroenterology Res 2018 Dec 17;11(6):430-435. Epub 2018 Dec 17.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. Read More

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http://dx.doi.org/10.14740/gr1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306111PMC
December 2018
4 Reads

Update on the pathology of liver neoplasms.

Ann Diagn Pathol 2019 Feb 12;38:126-137. Epub 2018 Oct 12.

Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195, United States of America; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, United States of America. Electronic address:

Many advances have developed in the pathology of liver tumors in the recent decade. Examples of these advances include the use of glutamine synthetase in the diagnosis of focal nodular hyperplasia, subtyping of hepatocellular adenomas using molecular and immunohistochemical methods, the unraveling of the fusion transcript between the DNAJB1 gene and the PRKACA gene in fibrolamellar carcinoma, and the more unified classification and terminology in intrahepatic bile duct tumors and their precursor lesions. Nevertheless, challenges still remain, e. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.10.005DOI Listing
February 2019
6 Reads

Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report.

Ann Hepatol 2018 Dec;18(1):263-268

Institute of Liver Studies, King's College Hospital, London, UK.

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3. Read More

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http://dx.doi.org/10.5604/01.3001.0012.7936DOI Listing
December 2018
4 Reads

Molecular Pathological Differences in Global Gene Expression between Two Sustained Proliferative Lesions, Nodular Regenerative Hepatocellular Hyperplasia and Hepatocellular Adenoma, in Mice.

Toxicol Pathol 2019 01 20;47(1):44-52. Epub 2018 Dec 20.

1 Division of Pathology, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.

Long-term exposure to piperonyl butoxide (PBO) induces multiple nodular masses along with hepatocellular tumors in the liver of mice. The histopathological features of the nodules led to our diagnosis of nodular regenerative hepatocellular hyperplasia (NRH). However, because of the lack of data on the biological characteristics of NRH, whether this lesion is truly nonneoplastic remains unknown. Read More

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http://dx.doi.org/10.1177/0192623318810200DOI Listing
January 2019
3 Reads

Evaluation of hepatic tumor portal perfusion using mesenteric angiography: A pilot study in 5 dogs.

J Vet Intern Med 2019 Mar 18;33(2):776-782. Epub 2018 Dec 18.

Lamb Statistical Consulting, West St. Paul, Minnesota.

Background: Mesenteric angiography is a sensitive method for visualizing portal perfusion in the dog.

Objectives: To evaluate hepatic portal perfusion in dogs with incompletely resectable hepatic tumors using mesenteric angiography.

Animals: Five client-owned dogs with incompletely resectable hepatic tumors evaluated with mesenteric angiography. Read More

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http://dx.doi.org/10.1111/jvim.15395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430931PMC
March 2019
6 Reads

Value of Texture Analysis on Gadoxetic Acid-Enhanced MRI for Differentiating Hepatocellular Adenoma From Focal Nodular Hyperplasia.

AJR Am J Roentgenol 2019 Mar 17;212(3):538-546. Epub 2018 Dec 17.

1 Department of Radiology, Abdominal Imaging Division, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213.

Objective: The objective of our study was to assess the diagnostic performance of texture analysis (TA) on gadoxetic acid-enhanced MR images for differentiation of hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH).

Materials And Methods: This study included 40 patients (39 women and one man) with 51 HCAs and 28 patients (27 women and one man) with 32 FNH lesions. All lesions were histologically proven with preoperative MRI performed with gadoxetic acid. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20182
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http://dx.doi.org/10.2214/AJR.18.20182DOI Listing
March 2019
15 Reads

New MRI features improve subtype classification of hepatocellular adenoma.

Eur Radiol 2019 May 6;29(5):2436-2447. Epub 2018 Dec 6.

CHU de Bordeaux, Service d'imagerie diagnostique et interventionnelle, Hôpital Haut-Lévêque, F-33604, Pessac, France.

Objective: MRI is crucial for the classification of hepatocellular adenomas (HCA) into subtypes. Our objective was to review and increase MRI criteria for subtype classification and define the limits.

Methods: Pathological and radiological data of 116 HCAs were retrospectively analyzed to investigate MRI features of HCA pathological subtypes. Read More

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http://dx.doi.org/10.1007/s00330-018-5784-5DOI Listing
May 2019
4 Reads

Hepatocellular carcinoma: a review of diagnostic challenges for the pathologist.

Authors:
Alberto Quaglia

J Hepatocell Carcinoma 2018 8;5:99-108. Epub 2018 Nov 8.

Department of Cellular Pathology, Royal Free Hospital, London NW3 2QG, UK,

Histopathologists retain a critical role in the diagnosis and management of hepatocellular carcinoma (HCC). HCC arises usually but not exclusively in a background of advanced-stage chronic liver disease. The histological diagnosis of HCC poses many challenges particularly when dealing with liver biopsy specimens due to the heterogeneity of HCC and the difficulty to confirm hepatocellular differentiation in some instances. Read More

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http://dx.doi.org/10.2147/JHC.S159808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235001PMC
November 2018
11 Reads

Impact of body mass index on CT attenuation of adrenal adenoma.

Eur J Radiol 2018 Nov 2;108:184-188. Epub 2018 Oct 2.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Objective: To investigate whether lipid metabolism-related factors regulate unenhanced CT attenuation in adrenal adenoma (AA).

Materials And Methods: Thirty-six patients with surgically proven AAs were enrolled in this study. The patients' underlying diseases were the following: primary aldosteronism (n = 24), Cushing's syndrome (n = 8), subclinical Cushing's syndrome (n = 3) and non-functioning AA (n = 1). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183034
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http://dx.doi.org/10.1016/j.ejrad.2018.09.033DOI Listing
November 2018
19 Reads

Ultrasound Imaging of Hepatocellular Adenoma Using the New Histology Classification.

Ultrasound Med Biol 2019 01 3;45(1):1-10. Epub 2018 Nov 3.

Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.

Hepatocellular adenoma is a rare benign liver tumor. Predisposing factors include hepatic storage diseases and some genetic conditions. A new histology-based classification has been proposed but to date, the corresponding ultrasound imaging features have not been reported. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03015629183027
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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.06.015DOI Listing
January 2019
14 Reads

Reevaluation of Hepatocellular Neoplasms in CD-1 Mice from a 2-year Oral Carcinogenicity Study with Permethrin.

Toxicol Pathol 2019 01 1;47(1):11-17. Epub 2018 Nov 1.

1 Experimental Pathology Laboratories, Inc., Research Triangle Park, North Carolina, USA.

A 24-month oral carcinogenicity study of permethrin was conducted by feeding male and female CD-1 mice diets containing concentrations of 0, 20, 500, and 2,000 ppm of permethrin (males) or 0, 20, 2,500, and 5,000 ppm of permethrin (females). After approximately two years on study, surviving mice were sacrificed for the evaluation of chronic toxicity and/or carcinogenicity. An expert panel of pathologists was convened as a Pathology Working Group (PWG) to review coded liver histology sections from male and female mice and to classify all liver neoplasms according to current nomenclature and diagnostic criteria guidelines. Read More

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http://dx.doi.org/10.1177/0192623318809304DOI Listing
January 2019
16 Reads
2.140 Impact Factor

Preliminary Report: Multiple Clusters of Proliferating Cells in Non-dysplastic Corrupted Colonic Crypts Underneath Conventional Adenomas.

Authors:
Carlos A Rubio

In Vivo 2018 Nov-Dec;32(6):1473-1475

Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital Stockholm, Stockholm, Sweden

Background: The finding was recently reported of clusters of colonic crypts lined with indigenous normal epithelium displaying irregular shapes underneath the adenomatous glands of conventional (tubular or villous) adenomas. These abnormal crypts were named non-dysplastic corrupted colonic crypts (NDCs). This study explored the characteristics of cell proliferation in NDCs present in a cohort of conventional adenomas. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11401
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http://dx.doi.org/10.21873/invivo.11401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365757PMC
January 2019
12 Reads

ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer.

BMC Cancer 2018 Oct 22;18(1):1020. Epub 2018 Oct 22.

Department of Geratic Surgery, Central South University, Xiangya Road 87, Changsha, Hunan, 410008, People's Republic of China.

Background: Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role in invasion and metastasis. Actin-like 6A (ACTL6A) is vital for embryogenesis and differentiation and is also critical for metastasis and EMT in hepatocellular carcinoma, as observed in our previous study. Read More

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http://dx.doi.org/10.1186/s12885-018-4931-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198485PMC
October 2018
1 Read

CHL1 expression differentiates Hürthle cell carcinoma from benign Hürthle cell nodules.

J Surg Oncol 2018 Nov 12;118(6):1042-1049. Epub 2018 Oct 12.

Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York.

Background And Objectives: Hürthle cell carcinoma (HCC) is an unusual and relatively rare type of differentiated thyroid cancer. Currently, cytologic analysis of fine-needle aspiration biopsy is limited in distinguishing benign Hürthle cell neoplasms from malignant ones. The aim of this study was to determine whether differences in the expression of specific genes could differentiate HCC from benign Hürthle cell nodules by evaluating differential gene expression in Hürthle cell disease. Read More

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http://doi.wiley.com/10.1002/jso.25214
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http://dx.doi.org/10.1002/jso.25214DOI Listing
November 2018
5 Reads
3.240 Impact Factor

Liver atoll sign: Inflammatory hepatocellular adenoma.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:89

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.36_12784
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http://dx.doi.org/10.1111/1754-9485.36_12784DOI Listing
October 2018
3 Reads

Contrast-enhanced ultrasound patterns of hepatocellular adenoma: an Italian multicenter experience.

J Ultrasound 2018 Oct 10. Epub 2018 Oct 10.

Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of Sacred Heart, Largo A. Gemelli 8, 00168, Rome, Italy.

Purpose: Hepatocellular adenoma (HCA) is a rare benign monoclonal neoplasm, recently categorized on genetic and histopathological basis into four subtypes with different biological behaviors. Since contrast-enhanced ultrasonography (CEUS) is nowadays a well-established technique for liver nodule characterization, the aim of our study was to assess CEUS features of HCAs to identify criteria that correlate with different HCA subtypes as compared to histopathologic examination and other imaging modalities.

Methods: We retrospectively analyzed data of patients with histology-proven HCA who underwent CEUS, computed tomography or magnetic resonance imaging (MRI) in seven different Italian ultrasound units. Read More

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http://link.springer.com/10.1007/s40477-018-0322-5
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http://dx.doi.org/10.1007/s40477-018-0322-5DOI Listing
October 2018
26 Reads

Molecular classification of hepatocellular adenomas: impact on clinical practice.

Hepat Oncol 2018 Jan 9;5(1):HEP04. Epub 2018 Apr 9.

Service d'Hépatologie, Hôpital Jean Verdier, Hôpitaux universitaires Paris-Seine-Saint-Denis, Assistance publique Hôpitaux de Paris, Bondy, France.

Hepatocellular adenomas are rare benign liver tumors usually developing in young women using oral contraception. The two main complications are hemorrhage (10-20%) and malignant transformation into hepatocellular carcinoma (<5%). A molecular classification has been recently updated in six major subgroups, linked to risk factors, histology, imaging and clinical features: adenomas inactivated for , inflammatory adenomas, β-catenin-activated adenomas mutated in exon 3, β-catenin-activated adenomas mutated in exon 7-8, sonic hedgehog adenomas, and unclassified adenomas. Read More

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https://www.futuremedicine.com/doi/10.2217/hep-2017-0023
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http://dx.doi.org/10.2217/hep-2017-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168043PMC
January 2018
3 Reads

Risk of hepatic neoplasms in Wolf-Hirschhorn syndrome (4p-): Four new cases and review of the literature.

Am J Med Genet A 2018 Nov 5;176(11):2389-2394. Epub 2018 Oct 5.

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

Wolf-Hirschhorn syndrome (WHS) is a rare contiguous gene deletion disorder characterized by distinctive craniofacial features, prenatal/postnatal growth deficiency, intellectual disability, and seizures. Various malformations of internal organs are also seen. Neoplasia has not been documented as a typical feature of WHS. Read More

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http://doi.wiley.com/10.1002/ajmg.a.40469
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http://dx.doi.org/10.1002/ajmg.a.40469DOI Listing
November 2018
4 Reads

Contrast-enhanced ultrasound in the diagnosis of pediatric focal nodular hyperplasia and hepatic adenoma: interobserver reliability.

Pediatr Radiol 2019 01 28;49(1):82-90. Epub 2018 Sep 28.

Department of Radiology, Kings College Hospital, Denmark Hill, London, SE5 9RS, UK.

Background: Focal nodular hyperplasia and hepatic adenoma are rare liver tumors in which specific features on contrast-enhanced ultrasound (US) have been reported but are little known in children.

Objective: To assess the interobserver agreement in diagnosing and differentiating focal nodular hyperplasia and hepatic adenoma in children using established adult contrast-enhanced US characteristics.

Materials And Methods: Thirty children with a definite or probable diagnosis of focal nodular hyperplasia or hepatic adenoma on magnetic resonance imaging (MRI)/histology who underwent contrast-enhanced US studies were included. Read More

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http://link.springer.com/10.1007/s00247-018-4250-5
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http://dx.doi.org/10.1007/s00247-018-4250-5DOI Listing
January 2019
9 Reads

Evaluation of texture analysis for the differential diagnosis of focal nodular hyperplasia from hepatocellular adenoma on contrast-enhanced CT images.

Abdom Radiol (NY) 2019 Apr;44(4):1323-1330

Abdominal Imaging Division, Department of Radiology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Purpose: To explore the value of CT texture analysis (CTTA) for differentiation of focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA) on contrast-enhanced CT (CECT).

Methods: This is a retrospective, IRB-approved study conducted in a single institution. A search of the medical records between 2008 and 2017 revealed 48 patients with 70 HCA and 50 patients with 62 FNH. Read More

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http://dx.doi.org/10.1007/s00261-018-1788-5DOI Listing
April 2019
2 Reads

Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of Hepatocellular Adenoma From Focal Nodular Hyperplasia.

J Magn Reson Imaging 2019 Mar 25;49(3):700-710. Epub 2018 Sep 25.

Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: Current imaging guidelines do not specify the preferred hepatobiliary contrast agent when differentiating hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH) on MRI.

Purpose: To analyze intrapatient differences in the hepatobiliary phase (HBP) after use of both gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA)-enhanced MRI to differentiate HCA from FNH.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.26227DOI Listing
March 2019
5 Reads

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

Cancer Res 2018 Nov 19;78(21):6098-6106. Epub 2018 Sep 19.

Department of Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, University of Amsterdam, Amsterdam, the Netherlands.

Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Here, we employ a model of epithelial-specific, heterozygous deletion by use of mice and organoids. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-17-3600DOI Listing
November 2018
19 Reads

[Polymetastatic highly aggressive Small Cell Undifferentiated Neuroendocrine Carcinoma of Ascending Colon].

Cir Cir 2018 ;86(5):446-449

Fourth Surgical Department. Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Neuroendocrine carcinoma (NEC) of the colon is a rare and very aggressive tumor with poor prognosis. The current case report presents a 53-year-old male with a 6 cm × 10 cm ascending colon carcinoma, causing large intestine obstruction, with simultaneous multiple hepatic metastases and peritoneal carcinomatosis. Surgical resection of the primary tumor was performed, because of the bowel obstruction, to ameliorate the symptoms before the onset of chemotherapy. Read More

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http://dx.doi.org/10.24875/CIRU.18000058DOI Listing
February 2019
4 Reads
0.322 Impact Factor