3,439 results match your criteria Hepatoblastoma Imaging


Disseminated lymphoid neoplasia and hepatoblastoma in an Atlantic stingray, Hypanus sabinus (Lesueur 1824).

J Fish Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, Georgia.

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December 2018

Inhibition of autophagy enhances adenosine‑induced apoptosis in human hepatoblastoma HepG2 cells.

Oncol Rep 2018 Nov 30. Epub 2018 Nov 30.

Department of Gastroenterology, The Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515041, P.R. China.

In cancer research, autophagy acts as a double‑edged sword: it increases cell viability or induces cell apoptosis depending upon the cell context and functional status. Recent studies have shown that adenosine (Ado) has cytotoxic effects in many tumors. However, the role of autophagy in Ado‑induced apoptosis is still poorly understood. Read More

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November 2018

Microscopically positive resection margin after hepatoblastoma resection: what is the impact on prognosis? A Childhood Liver Tumours Strategy Group (SIOPEL) report.

Eur J Cancer 2018 Dec 4;106:126-132. Epub 2018 Dec 4.

Department of Children and Adolescents Oncology, Gustave Roussy, Villejuif, Paris, France.

Background: To evaluate the impact of a microscopically positive resection margin (microPRM) on the outcome of hepatoblastoma patients pretreated with chemotherapy.

Methods: Local recurrence and survival rates of 431 children treated in the SIOPEL 2 and 3 trials were analysed comparing 58 patients with microPRM with 371 who had a complete resection (CR) and who were then stratified by risk category. The tumour was standard-risk in 312 patients and high-risk (PRETEXT IV and/or extrahepatic disease and/or α-fetoprotein [AFP]<100 ng/ml) in 117 patients. Read More

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December 2018

Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4.

Toxicology 2018 Nov 27;412:37-47. Epub 2018 Nov 27.

Institute of Biotechnology, Brandenburg University of Technology, Universitätsplatz 1, 01968, Senftenberg, Germany. Electronic address:

Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing, we have been generating cell clones of human hepatoblastoma cell line HepG2 by lentiviral transduction of phase I cytochrome P450 (CYP) enzymes. Here, we present a stable CYP2C19-overexpressing HepG2 cell clone (HepG2-2C19 C1) showing an enzyme activity of approximately 82 pmol x min x mg total cellular protein. Read More

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November 2018

Doxorubicin‑loaded dual‑functional hyaluronic acid nanoparticles: Preparation, characterization and antitumor efficacy in vitro and in vivo.

Mol Med Rep 2018 Nov 22. Epub 2018 Nov 22.

School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong 261053, P.R. China.

A novel GHH copolymer was synthesized using hyaluronic acid modified with glycyrrhetinic acid and L‑histidine (His), and doxorubicin‑loaded GHH nanoparticles (DOX/GHH) were prepared for liver‑targeted drug delivery and pH‑responsive drug release. In the present study, GHH nanoparticles were characterized, and their pH‑responsive behaviors were evaluated at different pH levels. The antitumor effect of the DOX/GHH nanoparticles was investigated in vitro and in vivo. Read More

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November 2018

STAT3-activated lncRNA LUCAT1 drives cell proliferation, migration and invasion in hepatoblastoma through regulating miR-301b/STAT3 axis.

Hum Gene Ther 2018 Nov 27. Epub 2018 Nov 27.

Beijing, China ;

Hepatoblastoma usually occurs in infant or toddlers. Nowadays, long non-coding RNAs (lncRNAs) have been widely studied in various human cancers. However, the role of lncRNAs in hepatoblastoma still needs to be elucidated. Read More

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November 2018

Adrenal Cortical Neoplasm with Uncertain Malignant Potential Arising in the Heterotopic Adrenal Cortex in the Liver of a Patient with Beckwith-Wiedemann Syndrome: A Case Report.

J Pathol Transl Med 2018 11 26. Epub 2018 Nov 26.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Patients with Beckwith-Wiedemann syndrome (BWS) are predisposed to developing embryonal tumors, with hepatoblastoma being the most common type. Our patient showed hemihypertrophy, macroglossia, and paternal uniparental disomy in chromosome 11 and was diagnosed with BWS. When the patient was nine months old, a 2. Read More

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November 2018
3 Reads

Wnt-β-catenin signalling in liver development, health and disease.

Nat Rev Gastroenterol Hepatol 2018 Nov 19. Epub 2018 Nov 19.

Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute - Donostia University Hospital - University of the Basque Country (UPV/EHU), San Sebastian, Spain.

The canonical Wnt-β-catenin pathway is a complex, evolutionarily conserved signalling mechanism that regulates fundamental physiological and pathological processes. Wnt-β-catenin signalling tightly controls embryogenesis, including hepatobiliary development, maturation and zonation. In the mature healthy liver, the Wnt-β-catenin pathway is mostly inactive but can become re-activated during cell renewal and/or regenerative processes, as well as in certain pathological conditions, diseases, pre-malignant conditions and cancer. Read More

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November 2018
5 Reads

Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma.

Transl Oncol 2018 Nov 6;12(2):200-208. Epub 2018 Nov 6.

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Hepatoblastoma is the most common primary liver tumor in children, but treatment has not changed significantly in the past 20 years. We have previously demonstrated that Proviral Integration site for Moloney murine leukemia (PIM) kinases promote tumorigenesis in hepatoblastoma. Stem cell-like cancer cells (SCLCCs) are a subset of cells thought to be responsible for chemoresistance, metastasis, relapse, and recurrence. Read More

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November 2018
4 Reads

Rubber tourniquet technique: A simple, safe, and cost-effective method of hepatic resection in neonates and infants.

Authors:
Zafar Nazir

J Pediatr Surg 2018 Oct 23. Epub 2018 Oct 23.

Section of Pediatric Surgery, Department of Surgery, The Aga Khan University, Stadium Road, Karachi 74800, Pakistan. Electronic address:

Background: Despite the improvements in patient care, understanding of surgical anatomy of liver and surgical techniques, liver resection is a high-risk procedure specifically in infants and neonates; whose blood volume is limited (80 ml/kg). This report shares the experience of hepatic resection with "Rubber tourniquet technique" in patients less than 6-months of age.

Methods: Hepatic resection in a 4-month-old pair of Conjoined twins with shared liver and a 3-day old baby with large Congenital Hepatoblastoma was performed using Penrose rubber drain as a tourniquet around the liver parenchyma to reduce blood loss. Read More

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October 2018

Evaluation of Aflatoxin M1 Effects on the Metabolomic and Cytokinomic Profiling of a Hepatoblastoma Cell Line.

Toxins (Basel) 2018 Oct 28;10(11). Epub 2018 Oct 28.

Unità di Farmacologia e Tossicologia-Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli "Federico II", 80138 Napoli, Italy.

Hepatoblastoma incidence has been associated with different environmental factors even if no data are reported about a correlation between aflatoxin exposure and hepatoblastoma initiation. Considering that hepatoblastoma develops in infants and children and aflatoxin M1 (AFM1), the aflatoxin B1 (AFB1) hydroxylated metabolite, can be present in mothers' milk and in marketed milk products, in this study we decided to test the effects of AFM1 on a hepatoblastoma cell line (HepG2). Firstly, we evaluated the effects of AFM1 on the cell viability, apoptosis, cell cycle, and metabolomic and cytokinomic profile of HepG2 cells after treatment. Read More

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October 2018
5 Reads

For Debate: The Significance of Etiologic Diagnosis in Neonates with Overgrowth Syndromes. Lesson Learned from the Simpson-Golabi-Behmel Syndrome.

Pediatr Endocrinol Rev 2018 Sep;16(1):171-177

Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.

Overgrowth syndromes are rare genetic disorders characterized by excessive pre- and postnatal growth accompanied by dysmorphic features and developmental disorders. In addition to other health hazards, the life expectancy of affected children may be compromised due to an increased risk of developing tumors. To demonstrate the need for early recognition, correct diagnostic evaluation and adequate follow-up, we present a family with recurrent Simpson-Golabi-Behmel syndrome (SGBS). Read More

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September 2018
6 Reads

Extracellular Vesicles in Hepatobiliary Malignancies.

Front Immunol 2018 12;9:2270. Epub 2018 Oct 12.

Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.

Primary hepatobiliary malignancies include a heterogeneous group of cancers with dismal prognosis, among which hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatoblastoma (HB) stand out. These tumors mainly arise from the malignant transformation of hepatocytes, cholangiocytes (bile duct epithelial cells) or hepatoblasts (embryonic liver progenitor cells), respectively. Early diagnosis, prognosis prediction and effective therapies are still a utopia for these diseases. Read More

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October 2018
8 Reads

Serum α-fetoprotein in pediatric oncology: not a children's tale.

Clin Chem Lab Med 2018 Oct 16. Epub 2018 Oct 16.

Department of Biomedical and Clinical Sciences 'Luigi Sacco', University of Milan, and Clinical Pathology Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.

Background Measurement of α-fetoprotein (AFP) concentrations in the serum of infants is useful for the management of testicular germ cell tumors, hepatoblastoma and hepatocellular carcinoma. Here, we provide a critical review of the available information about pediatric reference intervals (RI), focusing on their utility in interpreting AFP as an aid for cancer diagnosis. Content Evidence sources in the available literature were critically appraised. Read More

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October 2018
5 Reads

H19 suppresses the growth of hepatoblastoma cells by promoting their apoptosis via the signaling pathways of miR-675/FADD and miR-138/PTK2.

J Cell Biochem 2018 Oct 26. Epub 2018 Oct 26.

Department of Liver Disease, Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

Background: The objective of this study was to clarify the molecular pathways involved in hepatitis B virus (HBV)-induced hepatoblastoma.

Method: The expression of factors in different signaling pathways (H19, miR-675, miR-138, protein tyrosine kinase 2 [PTK2], fas-associated death domain [FADD], hypoxia-inducible factor 1-alpha [HIFIA], focal adhesion kinase [FAK], caspase-8, and caspase-3) was compared between HBV (+) and HBV (-) groups using quantitative real-time polymerase chain reaction and Western blot analysis. Subsequently, immunohistochemistry (IHC) and TdT-mediated dUTP Nick-End Labeling (TUNEL) assays were used to verify the expression of above proteins in HBV (+) and HBV (-) groups. Read More

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October 2018
11 Reads

Hepatocellular carcinoma in children: hepatic resection and liver transplantation.

Transl Gastroenterol Hepatol 2018 10;3:59. Epub 2018 Sep 10.

Division of Abdominal Transplantation and Hepatobiliopancreatic Surgery, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Hepatocellular carcinoma (HCC) is a rare malignancy in children and at the time of diagnosis up to 80% of pediatric HCC are unresectable due to large and multiple lesions. The majority of pediatric HCC occurs on a background of normal liver, and consequently the absence of concomitant chronic liver disease generally allows tolerating pre- and post-operative chemotherapy. Based on the large experiences of adult HCC and pediatric hepatoblastoma, in the last years a multidisciplinary aggressive treatment composed of surgical resection and chemotherapy (based on cisplatin and doxorubicin) has been proposed, improving patient outcomes and recurrence rate in children with HCC. Read More

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September 2018
7 Reads

Rs217727 polymorphism in H19 promotes cell apoptosis by regulating the expressions of H19 and the activation of its downstream signaling pathway.

J Cell Physiol 2018 Oct 26. Epub 2018 Oct 26.

Department of Liver Disease, Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

Background: The objective of the current study was to explore the role of H19 rs217727 polymorphism in the control of hepatocellular carcinoma (HCC).

Method: The Student's t test, Cox regression, and Kaplan-Meier analyses were used to clarify whether the H19 rs217727 polymorphism played an important role in the development of HCC. Real-time polymerase chain reaction (PCR) and western-blot analysis were carried out to measure the levels of H19, microRNA (miR)-675, FAS-associated death domain (FADD), caspase-8, and caspase-3 among H19 CC, CT, and TT groups, as well as in cells transfected with H19/si-H19, or miR-675 mimic/inhibitor. Read More

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October 2018
4 Reads

Role of TGF-β in Alcohol-Induced Liver Disease.

Adv Exp Med Biol 2018 ;1032:93-104

Center for Translational Medicine, Department of Surgery and George Washington Cancer Center, George Washington University, Washington, DC, USA.

Over 90% of hepatocellular carcinoma (HCC) occurs against a background of chronic liver disease or cirrhosis induced from viral hepatitis to alcohol injury. One third of patients with cirrhosis will develop HCC during their lifetime, with a 3-5% annual incidence. However, little is known about the key mechanisms by which toxins mediate DNA damage in the liver. Read More

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January 2018
4 Reads

Calcifying Nested Stromal-Epithelial Tumor of the Liver: An Update and Literature Review.

Arch Pathol Lab Med 2018 Oct 24. Epub 2018 Oct 24.

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Calcifying nested stromal epithelial tumor is a rare entity that has gone by a variety of names in the literature: ossifying malignant mixed epithelial and stromal tumor, ossifying stromal-epithelial tumor, and desmoplastic nested spindle cell tumor of the liver. To our knowledge, approximately 38 cases have been reported in the literature. The histogenesis is still largely unknown but histopathologically is characterized by nests of spindle and epithelioid cells in an organoid arrangement surrounded by a prominent dense myofibroblastic stroma with occasional psammomatous calcification and focal heterotopic ossification. Read More

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October 2018
2 Reads

Reiterative Radiofrequency Ablation in the Management of Pediatric Patients with Hepatoblastoma Metastases to the Lung, Liver, or Bone.

Cardiovasc Intervent Radiol 2019 Jan 22;42(1):41-47. Epub 2018 Oct 22.

Interventional Radiology Department, Gustave Roussy, Villejuif, 94805, France.

Background And Purpose: Conventional treatments of systemic chemotherapy and surgical resection for recurrent or metastatic hepatoblastoma (HB) may be inhibitive for the pediatric patient and family who have already been through extensive therapies. This single-institution case series evaluates the safety and efficacy of percutaneous radiofrequency ablation (RFA) in the management of metastatic HB.

Materials And Methods: Between March 2008 and February 2015, RFA was used as part of multidisciplinary management for HB recurrence or metastasis in 5 children (median 5. Read More

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January 2019
1 Read

Improved contemporary outcomes of liver transplantation for pediatric hepatoblastoma and hepatocellular carcinoma.

Pediatr Transplant 2018 12 19;22(8):e13305. Epub 2018 Oct 19.

Department of Surgery, Duke University Medical Center, Durham, North Carolina.

Purpose: Improvement in outcomes of LT for pediatric HB and HCC has been reported in small series. We analyzed national outcomes and changes in donor, recipient, and perioperative factors over time that may contribute to survival differences.

Methods: The UNOS database was queried for patients age <21 years that underwent LT for a primary diagnosis of HB or HCC (1987-2017). Read More

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December 2018
1 Read

Microwave ablation combined with transcatheter arterial chemoembolization is effective for treating unresectable hepatoblastoma in infants and children.

Medicine (Baltimore) 2018 Oct;97(42):e12607

Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children's Medical Center, Jinan University, Guangzhou, P.R. China.

The present study is to evaluate the feasibility and efficacy of microwave ablation (MWA) combined with transcatheter arterial chemoembolization (TACE) in the treatment for unresectable hepatoblastoma in infants and children. A total of 17 patients with PRETEXT stage III and IV hepatoblastoma that was unresectable by conventional resection were included in the present study. The patients were treated with TACE, MWA, and chemotherapy. Read More

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October 2018
4 Reads

Heme Oxygenase-1 May Affect Cell Signalling via Modulation of Ganglioside Composition.

Oxid Med Cell Longev 2018 19;2018:3845027. Epub 2018 Sep 19.

Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine and General University Hospital in Prague, Charles University, Katerinska 32, 12108 Prague, Czech Republic.

Heme oxygenase 1 (Hmox1), a ubiquitous enzyme degrading heme to carbon monoxide, iron, and biliverdin, is one of the cytoprotective enzymes induced in response to a variety of stimuli, including cellular oxidative stress. Gangliosides, sialic acid-containing glycosphingolipids expressed in all cells, are involved in cell recognition, signalling, and membrane stabilization. Their expression is often altered under many pathological and physiological conditions including cell death, proliferation, and differentiation. Read More

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December 2018
4 Reads

Targeting LRH‑1 in hepatoblastoma cell lines causes decreased proliferation.

Oncol Rep 2019 Jan 15;41(1):143-153. Epub 2018 Oct 15.

Divisions of Pediatric Surgery and Surgical Research, Michael E. DeBakey, Department of Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, TX 77030, USA.

Hepatoblastoma is the most common malignant liver tumor in children. Since it is often unresectable and exhibits drug resistance, the treatment of advanced hepatoblastoma is challenging. The orphan nuclear receptor liver receptor homolog‑1 (LRH‑1) serves prominent roles in malignancy; however, to the best of our knowledge, the role of LRH‑1 in hepatoblastoma remains unknown. Read More

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January 2019
2 Reads

Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population.

Dis Markers 2018 18;2018:7971019. Epub 2018 Sep 18.

Pathological Anatomy and Molecular Pathology Department, Hassan II University Hospital of Fez, Morocco.

Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) are a group of round cell tumors. Malignant round cell tumors form a large and diverse group that includes rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilm's tumor, desmoplastic small round cell tumor, and other morphologically similar entities. Differential diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) is difficult. Read More

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September 2018
3 Reads

Comparison between infantile hepatic hemangioendothelioma and hepatoblastoma in pediatric patients: clinical manifestations and contrast-enhanced computed tomography features.

Minerva Pediatr 2018 Oct;70(5):497-498

Department of Radiology, The Affiliated Hospital of Qingdao, University of Qingdao, Qingdao, China -

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October 2018
2 Reads
0.720 Impact Factor

Risk of hepatic neoplasms in Wolf-Hirschhorn syndrome (4p-): Four new cases and review of the literature.

Am J Med Genet A 2018 Nov 5;176(11):2389-2394. Epub 2018 Oct 5.

Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah.

Wolf-Hirschhorn syndrome (WHS) is a rare contiguous gene deletion disorder characterized by distinctive craniofacial features, prenatal/postnatal growth deficiency, intellectual disability, and seizures. Various malformations of internal organs are also seen. Neoplasia has not been documented as a typical feature of WHS. Read More

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November 2018
4 Reads

Reactive Ductules Are Associated With Angiogenesis and Tumor Cell Proliferation in Pediatric Liver Cancer.

Hepatol Commun 2018 Oct 25;2(10):1199-1212. Epub 2018 Sep 25.

Division of Pediatric General and Thoracic Surgery Cincinnati Children's Hospital Medical Center Cincinnati OH.

While reactive ductules (RDs) have been observed in viral hepatitis, biliary atresia, nonalcoholic fatty liver disease, and adult hepatocellular carcinoma (HCC), RDs in pediatric liver cancer remain uncharacterized. This study investigated the relationship of RDs with angiogenic paracrine factors, the extent of angiogenesis, and tumor cell proliferation in pediatric hepatoblastoma (HBL)/HCC livers. We quantified the extent of RDs and their expression of paracrine factors that include vascular endothelial growth factor (VEGF), vascular endothelial growth factor D (VEGFD), platelet-derived growth factor C, and angiopoietin 1 (ANGPT1). Read More

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October 2018
7 Reads

Ethylacetate extract from inhibits proliferation and induces apoptosis in HepG2 and SMMC-7721 cells.

Cancer Manag Res 2018 21;10:3793-3799. Epub 2018 Sep 21.

College of Forestry, Fujian Agriculture and Forestry University, Fuzhou City, Fujian Province 350001, China,

Purpose: This study aimed to investigate the effect of ethylacetate extract from (EET) on the proliferation and apoptosis of HepG2 and SMMC-7721 cells and determine the underlying mechanisms.

Materials And Methods: HepG2 and SMMC-7721 cells were cultured in vitro until the exponential growth phase and then treated with different concentrations of EET for 24 h. We performed a colony forming assay to determine colony forming ability, CCK8 assay to detect cell proliferation, Annexin V-FITC/PI double staining to analyze cell apoptosis, and Western blot to measure the protein expression of Caspase-3, Bcl-2, and Bax. Read More

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September 2018
1 Read

Nrf2 mediates the resistance of human A549 and HepG2 cancer cells to boningmycin, a new antitumor antibiotic, in vitro through regulation of glutathione levels.

Acta Pharmacol Sin 2018 Oct 10;39(10):1661-1669. Epub 2018 May 10.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100050.

NF-E2-related factor 2 (Nrf2) is a transcription factor and a pivotal factor in the induction of the cell defense system. Recent reports show that Nrf2 plays critical roles in tumor heterogeneity and drug resistance. In the present study we investigated whether and how Nrf2 mediated the resistance of human cancer cells to boningmycin (BON), a new antitumor antibiotic of the bleomycin family. Read More

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October 2018
1 Read
2.500 Impact Factor

A Case of Intracardiac Invasion of Hepatoblastoma Diagnosed With Point-of-Care Ultrasound.

Pediatr Emerg Care 2018 Oct;34(10):749-750

From the Department of Emergency and Critical Care Medicine, Kobe Children's Hospital, Kobe City, Hyogo, Japan.

Ultrasonography can be useful in the evaluation of children with abdominal complaints and may be the initial imaging modality in patients presenting with a newly recognized abdominal mass. Hepatoblastoma is an uncommon cause of acute abdominal pain in children and can rarely metastasize to the heart through vascular invasion. We report a case in which a 4-year-old girl who presented to the emergency department with abdominal pain promptly underwent point-of-care ultrasound and was subsequently diagnosed with intracardiac invasion of an abdominal tumor. Read More

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October 2018
3 Reads

PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma.

Commun Biol 2018 11;1:67. Epub 2018 Jun 11.

1Department of Pediatric Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, 45229 OH USA.

Hepatoblastoma (HBL) is a pediatric liver cancer that affects children under the age of three. Reduction of tumor suppressor proteins (TSPs) is commonly seen in liver cancer. However, in our studies we find that aggressive, chemo-resistant HBLs exhibit an elevation of TSPs. Read More

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Defining an optimal time window to screen for hepatoblastoma in children with Beckwith-Wiedemann syndrome.

Pediatr Blood Cancer 2019 Jan 30;66(1):e27492. Epub 2018 Sep 30.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Patients with Beckwith-Wiedemann spectrum (BWSp) undergo quarterly alpha-fetoprotein measurement for hepatoblastoma (HB) screening up to 4 years of age, paralleling the epidemiology of nonsyndromic HB. However, specific data on the timing of HB development in BWSp are lacking. Here we compare the timing of presentation of HBs in BWSp with a control cohort of consecutive HB cases, demonstrating that halving screening duration of screening procedures in BWSp likely will not impact its effectiveness. Read More

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January 2019

Treatment outcome and pattern of failure in hepatoblastoma treated with a consensus protocol in Hong Kong.

Pediatr Blood Cancer 2019 Jan 30;66(1):e27482. Epub 2018 Sep 30.

Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR.

Background And Aim: We reviewed the results and pattern of failure of the consensus HB/HCC 1996 treatment protocol for pediatric hepatoblastoma (HB) in Hong Kong. The role of SIOPEL and Children's Hepatic tumors International Collaboration (CHIC) risk stratification was evaluated.

Methods: Patients enrolled on the protocol from 1996 to 2014 were included. Read More

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January 2019
3 Reads
2.560 Impact Factor

Results of surgical resections with positive margins for children with hepatoblastoma: Case series from a single Asian center.

Pediatr Blood Cancer 2019 Jan 25;66(1):e27479. Epub 2018 Sep 25.

Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People's Republic of China.

The influence of margin status on the survival of patients with hepatoblastoma (HB) remains controversial. Here, we report long-term follow-up outcomes of 26 patients with HB who underwent hepatectomy with positive microscopic margins. Although these patients had microscopic residuals, the 5-year overall survival and event-free survival rates of those who had no metastases or macrovascular involvement (MVI) were 86. Read More

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January 2019

Pediatric hepatocellular carcinoma.

World J Gastroenterol 2018 Sep;24(35):3980-3999

Department of Pediatrics, King George Medical University, Uttar Pradesh 226003, India.

Pediatric hepatocellular carcinoma (HCC) is the second common malignant liver tumor in children after hepatoblastoma. It differs from the adult HCC in the etiological predisposition, biological behavior and lower frequency of cirrhosis. Perinatally acquired hepatitis-B virus, hepatorenal tyrosinemia, progressive familial intrahepatic cholestasis, glycogen storage disease, Alagille's syndrome and congenital portosystemic shunts are important predisposing factors. Read More

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September 2018
11 Reads

The association between sex and most childhood cancers is not mediated by birthweight.

Cancer Epidemiol 2018 Dec 21;57:7-12. Epub 2018 Sep 21.

Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Background: Male sex is associated with an increased risk of childhood cancer as is high birthweight. Given that sex determination precedes birthweight we conducted a mediation analysis to estimate the direct effect of sex in association with childhood cancer tumor type with birthweight as the mediator.

Methods: Cases (n = 12,632) and controls (n = 64,439) (ages 0-14 years) were identified from population-based cancer and birth registries in Minnesota, New York, and Washington states (1970-2014). Read More

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December 2018
2 Reads

Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition.

Pharmacol Res 2018 Nov 22;137:64-75. Epub 2018 Sep 22.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, Jiangsu Province, China. Electronic address:

Excess fructose consumption causes high prevalence of metabolic syndrome and inflammatory liver diseases. The aim of the current study was to investigate the therapeutic effects and underlying molecular mechanisms of curcumin and allopurinol in high fructose-induced hepatic inflammation. Male Sprague-Dawley rats were supplied with standard rat chow and drinking water containing 10% (w/v) fructose for consecutive 12 weeks. Read More

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November 2018
1 Read
4.410 Impact Factor

Resolvin D1 inhibits the proliferation of lipopolysaccharide-treated HepG2 hepatoblastoma and PLC/PRF/5 hepatocellular carcinoma cells by targeting the MAPK pathway.

Exp Ther Med 2018 Oct 23;16(4):3603-3610. Epub 2018 Aug 23.

Department of Interventional Radiology, Jiangsu Cancer Hospital, Nanjing, Jiangsu 210009, P.R. China.

Hepatocellular carcinoma (HCC) and hepatoblastoma are common malignant tumor types in China. The aim of the present study was to evaluate the effects of resolvin D1 (RvD1) on inflammatory factor levels and mitogen-activated protein kinase (MAPK) signaling in lipopolysaccharide (LPS)-treated liver cancer cells. First, HepG2 hepatoblastoma and PLC/PRF/5 HCC cells were cultured and treated with LPS with or without various concentrations of RvD1 (0, 0. Read More

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October 2018
0.940 Impact Factor

Roles of endoplasmic reticulum stress and autophagy on H2O2‑induced oxidative stress injury in HepG2 cells.

Mol Med Rep 2018 Nov 3;18(5):4163-4174. Epub 2018 Sep 3.

Department of Thyroid Breast Surgery, Shaoxing People's Hospital, Shaoxing, Zhejiang 312030, P.R. China.

Endoplasmic reticulum stress (ERS) can be induced by a variety of physiological and pathological factors including oxidative stress, which triggers the unfolded protein response to deal with ERS. Autophagy has been hypothesized to be a means for tumor cells to increase cell survival under conditions of hypoxia, metabolic stress and even chemotherapy. Although they may function independently from each other, there are also interactions between responses to oxidative stress injury induced by pathologic and pharmacological factors. Read More

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November 2018

Theanine, an antitumor promoter, induces apoptosis of tumor cells via the mitochondrial pathway.

Mol Med Rep 2018 Nov 5;18(5):4535-4542. Epub 2018 Sep 5.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210093, P.R. China.

Theanine, an active component of green tea (Camellia sinensis), is considered a modulator of chemotherapy. To further investigate the anticancer activity of theanine, the present study investigated the cytotoxic effect of theanine at the concentration of 600 µg/ml, in the human HepG2 hepatoblastoma and HeLa adenocarcinoma cell lines, in comparison with the normal L02, H9c2 and HEK293 cell lines using a MTT assay. It was found that theanine induced cell death in the tumor cells, but not in the normal cells. Read More

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November 2018
4 Reads

Diagnosis, histopathologic correlation and management of hepatoblastoma: What the radiologist needs to know.

Clin Imaging 2018 Nov - Dec;52:273-279. Epub 2018 Aug 18.

Department of Radiology, Seattle Children's Hospital, Seattle, WA 98105, United States.

Hepatoblastomas are complex pediatric tumors with several pathological subtypes, some of which demonstrate differing imaging features and portend varying prognosis. The radiologist plays a major role not only in the pre-surgical evaluation and baseline staging of the tumor, but also in guiding management and evaluating prognosis based on the PRETEXT (pretreatment extent of tumor) classification. We discuss the pathology, imaging features, and baseline evaluation, with a focus on the role of the radiologist in the management of these tumors. Read More

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August 2018
4 Reads
0.600 Impact Factor

Assessing the feasibility and validity of the Toronto Childhood Cancer Stage Guidelines: a population-based registry study.

Lancet Child Adolesc Health 2018 Mar 1;2(3):173-179. Epub 2018 Feb 1.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MD, USA.

Background: Cancer stage at diagnosis is crucial for assessing global efforts to increase awareness of childhood cancer and improve outcomes. However, consistent information on childhood cancer stage is absent from population cancer registries worldwide. The Toronto Childhood Cancer Stage Guidelines, compiled through an international consensus process, were designed to provide a standard framework for collection of information on stage at diagnosis of childhood cancers. Read More

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March 2018
15 Reads

Dose modifications and pharmacokinetics of adjuvant cisplatin monotherapy while on hemodialysis for patients with hepatoblastoma.

Pediatr Blood Cancer 2019 Jan 30;66(1):e27425. Epub 2018 Aug 30.

Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Hepatoblastoma can be associated with chronic kidney disease and genitourinary anomalies. Cisplatin is a key agent for treating hepatoblastoma but renal clearance and toxicity can limit its use in end-stage renal disease. We present pharmacokinetic data and clinical outcomes using cisplatin on hemodialysis for three patients with hepatoblastoma. Read More

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January 2019

A cross-sectional study of the distribution of pediatric solid tumors at an Indian tertiary cancer center.

Indian J Cancer 2018 Jan-Mar;55(1):55-60

Department of Biostatistics, Tata Memorial Hospital, Mumbai, Maharashtra, India.

Context: Pediatric solid tumors include a heterogeneous group of tumors, and the burden of these tumors, especially from resource-challenged countries, is not well described. AIMS: The aim of this study was to describe the distribution of solid tumors in children and the treatment outcome of Wilms tumor and hepatoblastoma.

Patients And Methods: All patients under 15 years of age with histologically confirmed tumors presenting at a tertiary cancer center from January 2012 to December 2016 were identified from the hospital database. Read More

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November 2018
31 Reads

Endoglin-targeted contrast-enhanced ultrasound imaging in hepatoblastoma xenografts.

Oncol Lett 2018 Sep 4;16(3):3784-3790. Epub 2018 Jul 4.

Department of Ultrasonography, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

Angiogenesis is required for the growth of hepatoblastoma (HB). In the present study, an ultrasonic contrast agent, microbubbles (MB), was combined with an endoglin antibody, and then injected into nude mice with HB. This was conducted to detect specific binding to microvessels via non-linear harmonic imaging for tumor angiogenesis assessment. Read More

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September 2018
9 Reads