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Ann Clin Lab Sci 2022 May;52(3):475-483

Department of Pathology, Stanford University School of Medicine, Stanford

Objective: The objectives of this study are to define the specificity of the fusion transcript for the fibrolamellar subtype of hepatocellular carcinoma (FL-HCC) by testing a targeted sampling of other hepatic neoplasms/proliferations and extrahepatic neoplasms seen in children and young adults and to develop a FISH assay using a commercially available break apart probe for use in a CLIA-certified clinical laboratory.

Methods: Formalin fixed paraffin embedded tissue sections from 12 FL-HCC cases, 142 cases of other hepatic neoplasms/proliferations (conventional HCC, focal nodular hyperplasia (FNH), hepatocellular adenoma (HA) and hepatoblastoma (HB)) and extrahepatic neoplasms (neuroblastoma (NB), Wilms tumor (WT) and Gastrointestinal neuroendocrine tumor (GNET)) and 60 matched background normal control tissues underwent fluorescence in situ hybridization (FISH) testing using a break apart probe targeting the gene locus on chromosome 19 using standard techniques.

Results: The gene rearrangement was detected in 11/12 (92%) FL-HCC cases and 1/94 (1%) of conventional HCC cases. Read More

Korean J Transplant 2020 Mar;34(1):47-54

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: To understand the changing demands and recent trends in the indications for living donor liver transplantation (LDLT), the present study aimed to analyze the indications for LDLT performed in a high-volume transplantation center over 10 years.

Methods: The liver transplantation database at our institution was searched to identify patients who underwent LDLT during a 10-year period from January 2008 to December 2017. The study subjects (n=3,145) were divided into two groups: adult patients (n=3,019, 92. Read More

Korean J Transplant 2020 Dec 16;34(4):293-301. Epub 2020 Dec 16.

Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Laparoscopically harvested left liver (LL) grafts have drawbacks with respect to the size and shape of graft hepatic vein orifices. We present two cases of pediatric living donor liver transplantation (LDLT) using laparoscopically harvested LL grafts and describe refined surgical techniques for graft hepatic vein venoplasty. The first case was a boy aged 4 years and 5 months, with hepatoblastoma. Read More

Korean J Transplant 2021 Jun 7;35(2):93-99. Epub 2021 Apr 7.

Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: Liver transplantation (LT) for foreign patients is a sensitive issue because of possibility of transplant tourism and difficulty in posttransplant follow-up. This study describes the institutional standard framework and experience of living donor LT (LDLT) for overseas non-Korean patients in a Korean high-volume LDLT center.

Methods: The framework and experience of LDLT for 105 non-Korean patients from 2010 to 2019 were retrospectively investigated. Read More

Comput Intell Neurosci 2022 16;2022:3045370. Epub 2022 Jun 16.

College of Artificial Intelligence, Southwest University, Chongqing 400715, China.

The objective of this research was to investigate the application value of deep learning-based computed tomography (CT) images in the diagnosis of liver tumors. Fifty-eight patients with liver tumors were selected, and their CT images were segmented using a convolutional neural network (CNN) algorithm. The segmentation results were quantitatively evaluated using the Dice similarity coefficient (DSC), precision, and recall. Read More

Molecules 2022 Jun 16;27(12). Epub 2022 Jun 16.

Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani 34190, Thailand.

The present study aimed to investigate the effect of acridone alkaloids on cancer cell lines and elucidate the underlying molecular mechanisms. The ten acridone alkaloids from were screened for cytotoxicity against LNCaP cell lines by a WST-8 assay. Then, the most potential acridone, buxifoliadine E, was evaluated on four types of cancer cells, namely prostate cancer (LNCaP), neuroblastoma (SH SY5Y), hepatoblastoma (HepG2), and colorectal cancer (HT29). Read More

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):368-370. Epub 2022 May 12.

Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Pediatric liver masses are rare and difficult to treat. Common liver masses in children include hepatoblastoma, hemangiomas, liver abscesses, and hydatid disease. Isolated liver tuberculosis (TB) is rare in children and can have variable clinical presentations. Read More

J Indian Assoc Pediatr Surg 2022 May-Jun;27(3):317-322. Epub 2022 May 12.

Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Recent SIOPEL studies have shown cisplatin monotherapy to be equally effective in management of Standard risk Hepatoblastoma (SRHB)as compared to PLADO.

Aims And Objectives: To study the chemotherapy, response and outcomes in children with SRHB.

Material And Methods: A retrospective study was conducted and all children with SRHB who presented to us from June 2007 to December 2017 were included. Read More

Cell Rep 2022 Jun;39(12):110988

Cancer and Leukaemia Epigenetics and Biology Program, Josep Carreras Leukaemia Research Institute (IJC), Campus ICO-GTP-UAB, Badalona, Barcelona 08916, Spain; Program for Predictive and Personalized Medicine of Cancer, Germans Trias i Pujol Research Institute (PMPPC-IGTP), Badalona, Barcelona 08916, Spain. Electronic address:

MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1.2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. Read More

Front Surg 2022 1;9:908381. Epub 2022 Jun 1.

Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

Purpose: This study aims to explore the clinical value of a computer-assisted surgery system (Hisense CAS) in hepatoblastoma (HB) surgery in children after neoadjuvant chemotherapy.

Patients And Methods: The clinical medical records of children with HB treated after neoadjuvant chemotherapy at the Affiliated Hospital of Qingdao University from January 2016 to January 2019 were analyzed retrospectively.

Results: A total of 21 children were enrolled in this study, including 13 boys and 8 girls. Read More

Rev Col Bras Cir 2022 13;49:e20223273. Epub 2022 Jun 13.

- Hospital Pequeno Príncipe, Cirurgia Pediátrica - Curitiba - PR - Brasil.

Introduction: liver tumors are rare neoplasms in childhood (1-2%), and about 2/3 are malignant. Hepatoblastoma (HB) is the most frequent, followed by hepatocellular carcinoma (HCC). In both, the main treatment is surgical resection. Read More

Analyst 2022 Jun 14. Epub 2022 Jun 14.

Department of Clinical Laboratory, Shanghai Tenth People's Hospital Chong Ming Branch, 202150, China.

Alpha-fetoprotein (AFP) is an important clinical tumor marker of hepatoblastoma, and the concentration of AFP in serum is closely related to the staging of hepatoblastoma. We report a magnetic bead separation platform based on a switching aptamer triggered hybridization chain reaction (SAT-HCR) and the CRISPR-Cas12a sensor for the detection of AFP. AFP aptamer, as an easily regulated nucleic acid strand, is responsible for binding to AFP into nucleic acid detection, while HCR-CRISPR-Cas12a, regulated by functionalized magnetic nanoparticles, is responsible for highly specific nucleic acid signal amplification. Read More

Am J Cancer Res 2022 15;12(5):1960-1981. Epub 2022 May 15.

Department of Pediatric Surgery, Children's Hospital of Fudan University 399 Wanyuan Road, Shanghai 201102, China.

Hepatoblastoma (HB) accounts for the majority of hepatic malignancies in children. Although the prognosis of patients with HB has improved in past decades, metastasis is an indicator of poor overall survival. Herein, we applied single-cell RNA sequencing to explore the transcriptomic profiling of 25,264 metastatic cells isolated from the lungs of two patients with HB. Read More

Int Forum Allergy Rhinol 2022 Jun 11. Epub 2022 Jun 11.

Skull Base Surgery Unit Department of Otorhinolaryngology, Christian Medical College, Vellore, Tamil Nadu, India.

Front Oncol 2022 24;12:887210. Epub 2022 May 24.

Research Department, Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.

Virtually every cell in the body releases extracellular vesicles (EVs), the contents of which can provide a "fingerprint" of their cellular origin. EVs are present in all bodily fluids and can be obtained using minimally invasive techniques. Thus, EVs can provide a promising source of diagnostic, prognostic, and predictive biomarkers, particularly in the context of cancer. Read More

Paediatr Perinat Epidemiol 2022 Jun 7. Epub 2022 Jun 7.

Cancer Council Queensland, Brisbane, Queensland, Australia.

Background: Large improvements in childhood cancer survival have been reported over recent decades. Data from cancer registries have the advantage of providing a 'whole of population' approach to gauge the success of cancer control efforts.

Objectives: The aim of this study was to investigate recent survival estimates for children diagnosed with cancer Australia and to examine the extent of changes in survival over the last 35 years. Read More

J Cancer Res Ther 2022 Apr;18(2):370-377

Department of General Surgery, Tianjin Children's Hospital, Tianjin, China.

Aims: Hepatoblastoma (HB) was reported as the frequently diagnosed primary hepatic malignant tumor among children. No reports have shown the function of SOX7 and its relationship with the Wnt/β-catenin pathway in HB.

Materials And Methods: SOX7 and factors related to Wnt/β-catenin pathway were detected using reverse transcription-quantitative polymerase chain reaction (RT-PCR) and Western blotting. Read More

Liver Cancer 2022 Apr 21;11(2):126-140. Epub 2021 Dec 21.

MIRCADE Team, Univ. Bordeaux, Inserm, BMGIC, Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers, U1035, Bordeaux, France.

Introduction: Hepatocellular carcinoma and hepatoblastoma are two liver cancers characterized by gene deregulations, chromosomal rearrangements, and mutations in Wnt/beta-catenin (Wnt) pathway-related genes. LHX2, a transcriptional factor member of the LIM homeobox gene family, has important functions in embryogenesis and liver development. LHX2 is oncogenic in many solid tumors and leukemia, but its role in liver cancer is unknown. Read More

Cardiol Young 2022 May 25:1-6. Epub 2022 May 25.

Department of Pediatric Cardiology, Dr. Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.

Objective: Patent ductus arteriosus is an important cause of morbidity and mortality, especially in very low birth weight infants. The aim of the study is to report our single-centre short-term results of preterm patients who underwent ligation through left anterior mini-thoracotomy .

Methods: Data of 27 preterm infants operated by the same surgeon who underwent Patent ductus arteriosus (PDA) closure with left anterior mini-thoracotomy technique between November 2020 and January 2022 at a single institution were reviewed. Read More

Clin Transl Med 2022 May;12(5):e889

School of Basic Pharmaceutical and Toxicological Sciences, the University of Louisiana at Monroe, Monroe, Louisiana, USA.

Ann Med Surg (Lond) 2022 Jun 13;78:103693. Epub 2022 May 13.

Department of Neonatal and Pediatric Surgery, VietDuc University Hospital, Hanoi, Viet Nam.

Hepatoblastoma originating in the caudate lobe (segment 1) is extremely rare. Complete resection of the caudate lobe, without sacrificing other parts of the liver, remains a surgical challenge. We present our experience with laparoscopic complete resection of caudate lobe hepatoblastoma for a 7-years-old girl, with a history of hepatitis B. Read More

Med Mol Morphol 2022 May 21. Epub 2022 May 21.

Department of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan.

Tumor-associated macrophages (TAMs) have protumor functions in various cancers. However, their significance in hepatoblastoma, the most common liver tumor in children, remains unclear. The aim of this study was to explore the potential roles of TAMs in hepatoblastoma. Read More

Pediatr Blood Cancer 2022 May 19:e29763. Epub 2022 May 19.

Section Pediatric Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

Objective: Hepatoblastoma (HB) is the most common pediatric primary malignant liver tumor, its incidence has been increasing worldwide, but recent changes in incidence and outcomes with high population coverage are not well characterized.

Methods: We defined the incidence of HB diagnosed during 2003-2017 from United States Cancer Statistics (USCS) database, and survival during 2001-2016 from the National Program of Cancer Registries (NPCR). Data were stratified by sex, race/ethnicity, age, tumor stage, county population, and diagnosis year. Read More

Nat Prod Res 2022 May 18:1-11. Epub 2022 May 18.

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.

is used as a medicinal fungus in Taiwan to treat fatigue, food intoxication, and enhance liver function. Here we identified fermented metabolic components from the mycelium of KH37 and explored their anti-hepatoma potentials with study models of human hepatoblastoma cell lines. Bioassay-guided fractionation of the solid fermentation powder of KH37 led to the isolation of one new quinonol, antroquinonol Z (), and nine known compounds (-). Read More

J Hepatol 2022 May 13. Epub 2022 May 13.

Departments of Pediatrics; Departments of Pathology & Immunology. Electronic address:

Background & Aims: Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the predominant types of liver cancers in children. HB and HCC outcomes and treatment options differ dramatically and most HBs have favorable outcomes following treatment by a combination of chemotherapy and resection. Risk-stratification using a combination of clinical, histological, and molecular parameters can improve therapy selection for these patients, but it is particularly challenging for tumors with mixed HB and HCC histological features, including those in the recently created hepatocellular neoplasm not otherwise specified (HCN NOS) provisional category. Read More

Exp Clin Transplant 2022 05;20(Suppl 3):62-65

From the Department of Pediatric Gastroenterology, Hacettepe University Hospitals, Ankara, Turkey.

Hepatoblastoma is the most common primary liver cancer of childhood, accounting for two-thirds of primary malignant hepatic neoplasms. Radical surgical removal combined with efficient chemotherapy is essential for cure. Despite a complete tumor resection, hepatoblastoma may recur as isolated local disease. Read More

Cells 2022 04 30;11(9). Epub 2022 Apr 30.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2B7, Canada.

Hepatoblastoma (HB) is a rare primary malignancy of the developing fetal liver. Its course is profoundly influenced by genetics, in the context of sporadic mutation or genetic syndromes. Conventionally, subtypes of HB are histologically determined based on the tissue type that is recapitulated by the tumor and the direction of its differentiation. Read More

Cancer 2022 Jul 13;128(14):2786-2795. Epub 2022 May 13.

Division of Pediatric Surgery, Children's Hospital, London Health Sciences Center, London, Ontario, Canada.

Background: Hepatocellular carcinoma (HCC) is a rare cancer in children, with various histologic subtypes and a paucity of data to guide clinical management and predict prognosis.

Methods: A multi-institutional review of children with hepatocellular neoplasms was performed, including demographic, staging, treatment, and outcomes data. Patients were categorized as having conventional HCC (cHCC) with or without underlying liver disease, fibrolamellar carcinoma (FLC), and hepatoblastoma with HCC features (HB-HCC). Read More

Pediatr Blood Cancer 2022 May 13:e29778. Epub 2022 May 13.

Division of Pediatric Hemato Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.