32,815 results match your criteria Hepatobiliary & Pancreatic Diseases International HBPD Int[Journal]


Acute kidney injury after hepatectomy can be reasonably predicted after surgery.

J Hepatobiliary Pancreat Sci 2019 Feb 22. Epub 2019 Feb 22.

Department of Anesthesiology, Columbia University Medical Center, New York, NY.

Background: Hepatectomy presents unique challenges potentially heightening acute kidney injury risk, but the full spectrum of risk factors have not been identified.

Methods: Data for hepatectomy patients in the 2016 American College of Surgeons National Surgical Quality Improvement Program (N=3814) was randomly split into derivation (70%) and validation (30%) cohorts. AKI was defined as an increase in serum creatinine ≥0. Read More

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http://dx.doi.org/10.1002/jhbp.615DOI Listing
February 2019

Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention.

Food Funct 2019 Feb 22. Epub 2019 Feb 22.

Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region, School of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, PR China. and Research Center of Brain Intellectual Promotion and Development for Children Aged 0-6 Years, Chongqing University of Education, Chongqing 400067, PR China.

Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-α/receptor-interacting protein kinase 3 (TNF-α/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive flavonoid polyphenol with anti-inflammatory and anti-tumor activity. Read More

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http://dx.doi.org/10.1039/c8fo01615aDOI Listing
February 2019

Normative values for magnetic resonance elastography-based liver stiffness in a healthy population.

Pol Arch Intern Med 2019 Feb 22. Epub 2019 Feb 22.

INTRODUCTION Chronic liver disease resulting in fibrosis, and ultimately cirrhosis, is a significant cause of morbidity and mortality worldwide. None of the conventional imaging techniques are able to detect early fibrosis and compare its grade with the histopathologic scale. Liver biopsy, as the diagnostic standard for liver fibrosis, also has limitations and is not well accepted by patients. Read More

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http://dx.doi.org/10.20452/pamw.4456DOI Listing
February 2019

Liver cancer: WISP3 suppresses hepatocellular carcinoma progression by negative regulation of β-catenin/TCF/LEF signalling.

Cell Prolif 2019 Feb 22:e12583. Epub 2019 Feb 22.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Objectives: Wnt1-inducible signalling pathway protein 3 (WISP3/CCN6) belongs to the CCN (CYR61/CTGF/NOV) family of proteins, dysregulation of this family contributed to the tumorigenicity of various tumours. In this study, we need to explore its role in hepatocellular carcinoma that remains largely elusive.

Materials And Methods: The expression of WISP3/CCN6 was analysed by qRT-PCR and Western blotting. Read More

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http://dx.doi.org/10.1111/cpr.12583DOI Listing
February 2019

Quantitative Evaluation of Display Contrast of Gd-EOB-DTPA-Enhanced Magnetic Resonance Images: Effects of the Flip Angle and Grayscale Gamma Value.

Radiol Res Pract 2019 16;2019:7630671. Epub 2019 Jan 16.

Department of Diagnostic Radiology, Kitasato University Hospital, Sagamihara, Kanagawa, Japan.

Introduction: Display contrast can be changed nonlinearly by manipulating the gamma value of the grayscale. We investigated the contrast of the hepatobiliary-phase images acquired with different flip angles (FAs) and displayed with different gamma values in Gd-EOB-DTPA-enhanced magnetic resonance imaging.

Material And Methods: Twenty patients with liver tumors were studied. Read More

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http://dx.doi.org/10.1155/2019/7630671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354155PMC
January 2019

Cystic fibrosis and portal hypertension: Distal splenorenal shunt can prevent the need for future liver transplant.

J Pediatr Surg 2019 Feb 2. Epub 2019 Feb 2.

Division of Transplant Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

Background: The management of portal hypertension (PHT) in children with well compensated cirrhosis and cystic fibrosis (CF) is controversial. We present our experience with distal splenorenal shunting (DSRS) for the treatment of PHT as an alternative to liver transplantation (LT).

Methods: Between 2008 and 2017, 5 CF children underwent a DSRS at a pediatric hepatobiliary and transplantation referral center. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.035DOI Listing
February 2019

Graft protection of the liver by hypothermic machine perfusion involves recovery of graft regeneration in rats.

J Int Med Res 2019 Jan;47(1):427-437

1 Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective: This study was performed to evaluate the impact and underlying mechanisms of hypothermic machine perfusion (HMP) on half-size liver graft regeneration.

Methods: Forty rats were randomly assigned to five groups: two in vitro groups (static cold storage [SCS] and HMP) and three in vivo groups (orthotopic liver transplantation, SCS, and HMP). Perfusates and plasma samples were collected for analysis of hepatic enzymes. Read More

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http://dx.doi.org/10.1177/0300060518787726DOI Listing
January 2019

Extraintestinal manifestations in inflammatory bowel disease - epidemiology, genetics, and pathogenesis.

Expert Rev Gastroenterol Hepatol 2019 Feb 4:1-11. Epub 2019 Feb 4.

a Department of Gastroenterology and Hepatology , University Hospital Zurich , Zurich , Switzerland.

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily of, but not restricted to the gut. Extraintestinal manifestations (EIMs) are frequently observed and involve the joints, eyes, hepatobiliary tract, and skin. Areas covered: In this review, we discuss classical EIM focusing on epidemiology, genetics, and pathogenesis, highlighting recent advances in the understanding of EIM. Read More

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http://dx.doi.org/10.1080/17474124.2019.1574569DOI Listing
February 2019

Effect of ω-3 polyunsaturated fatty acids on liver function and inflammatory reaction in patients undergoing hepatectomy: a systematic review and meta-analysis of randomized control trials.

Expert Rev Gastroenterol Hepatol 2019 Feb 7. Epub 2019 Feb 7.

a Hepatobiliary Surgery Department and Unit of Organ Transplantation , First Hospital of China Medical University , Shenyang 110001 , Liaoning , P.R. China.

Introduction: Several studies have investigated the relationship between ω-3 polyunsaturated fatty acids (PUFAs) administration and liver function and inflammatory reaction in patients undergoing liver resection, but the results remain conflicting and inconclusive. Areas covered: In this meta-analysis, a relevant database search was performed to retrieve all the randomized controlled trials (RCTs) exploring the effect of ω-3 PUFAs administration in patients undergoing hepatectomy until the end of April 2018. A random effect model was used to conduct this meta-analysis with RevMan 5. Read More

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http://dx.doi.org/10.1080/17474124.2019.1578648DOI Listing
February 2019

Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

It has been proposed that the circadian rhythm generally plays important roles in tumor suppression, but there is also evidence that disruption of the canonical circadian pathway has anticancer effects. In this study, we systematically analyzed the aberrances of circadian clock genes across cancers based on data from The Cancer Genome Atlas (TCGA). These data showed that the frequencies of mutations and copy number alterations in core clock genes (PER1/2/3, CLOCK, CRY1/2, and ARNTL) were low, but that the expression levels of core clock genes were downregulated by the higher levels of DNA methylation in most tumors. Read More

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http://dx.doi.org/10.1002/cam4.2035DOI Listing
February 2019

Targeted next generation sequencing identified novel loss-of-function mutations in MERTK gene in Chinese patients with retinitis pigmentosa.

Mol Genet Genomic Med 2019 Feb 20:e577. Epub 2019 Feb 20.

Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong, R.P. China.

Background: Retinitis pigmentosa (RP) is one of the major types of hereditary retinal dystrophies with extreme genotypic heterogeneity. To date, more than 80 genes have been identified to be associated with RP in human.

Method: Here, we presented a clinical genetic study of three Chinese man manifested with night vision blindness and complete loss of midperipheral visual field. Read More

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http://dx.doi.org/10.1002/mgg3.577DOI Listing
February 2019

A Clinical Scoring System for Predicting Microvascular Invasion in Patients with Hepatocellular Carcinoma Within the Milan Criteria.

J Gastrointest Surg 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Background: Microvascular invasion (MVI) is recognized as a risk factor for early recurrence of hepatocellular carcinoma (HCC) within the Milan criteria after curative treatment.

Methods: One hundred eleven consecutive patients with HCC within the Milan criteria who underwent hepatic resection were retrospectively reviewed. Independent preoperative predictors of MVI were identified, and a scoring system was developed using significant predictors. Read More

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http://dx.doi.org/10.1007/s11605-019-04134-yDOI Listing
February 2019

Feasibility of terahertz imaging for discrimination of human hepatocellular carcinoma.

World J Gastrointest Oncol 2019 Feb;11(2):153-160

Advanced Interdisciplinary Technology Research Center, National Innovation Institute of Defense Technology, Beijing 100071, China.

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, and novel methods for early/rapid diagnosis of HCC are needed. Terahertz (THz) spectroscopy is considered to have the potential to distinguish between normal liver tissue and HCC tissue; however, there are few reports on it. We conduct this observational study to explore the feasibility of THz imaging for the diagnosis of HCC. Read More

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http://dx.doi.org/10.4251/wjgo.v11.i2.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379755PMC
February 2019

Analysis the prognostic values of solute carrier (SLC) family 39 genes in gastric cancer.

Am J Transl Res 2019 15;11(1):486-498. Epub 2019 Jan 15.

Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation Hangzhou 310003, Zhejiang Province, China.

Background: Gastric cancer (GC) is one of the most common diagnosed cancer with poor prognosis. Solute carrier (SLC) family 39 genes encode membrane transport proteins, which control the influx of zinc and may play important roles in human disease including cancer. However, the prognostic value of individual SLC family 39 gene in gastric cancer patients remain unclear. Read More

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January 2019

Gemcitabine enhances OSI-027 cytotoxicity by upregulation of miR-663a in pancreatic ductal adenocarcinoma cells.

Am J Transl Res 2019 15;11(1):473-485. Epub 2019 Jan 15.

Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University No. 79 Qingchun Road, Hangzhou 310003, China.

Pancreatic ductal adenocarcinoma (PDAC) is well-known to be the most deadly malignancy with the worst survival rate of all cancers. Gemcitabine-based chemotherapy is the most common treatment option for pancreatic ductal adenocarcinoma. However, it offers little therapeutic value in many cases due to the rapid development of chemoresistance. Read More

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January 2019

NVP-BEZ235-induced autophagy as a potential therapeutic approach for multiple myeloma.

Am J Transl Res 2019 15;11(1):87-105. Epub 2019 Jan 15.

Department of Hematology, Nanfang Hospital, Southern Medical University Guangzhou 510010, China.

Background: The PI3K/Akt/mTOR pathway is constitutively activated in human multiple myeloma (MM) cell lines and in freshly isolated plasmocytes from patients with MM. The mTOR signaling pathway has been designated an attractive anti-tumor target in multiple myeloma. NVP-BEZ235, a novel, dual class I PI3K/mTOR inhibitor, is an imidazoquinoline derivative. Read More

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January 2019

Lnc-PDZD7 contributes to stemness properties and chemosensitivity in hepatocellular carcinoma through EZH2-mediated ATOH8 transcriptional repression.

J Exp Clin Cancer Res 2019 Feb 20;38(1):92. Epub 2019 Feb 20.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, Guangxi, 530021, People's Republic of China.

Background: Hepatocellular carcinoma (HCC) with stemness features are pivotal for tumorigenesis, chemoresistance, and progression. Long non-coding RNAs have been implicated in the regulation of HCC stemness features; however, their mechanisms remain largely unknown. Here, we found that Lnc-PDZD7 is a potential oncogene. Read More

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http://dx.doi.org/10.1186/s13046-019-1106-2DOI Listing
February 2019

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance.

Autophagy 2019 Feb 20:1-22. Epub 2019 Feb 20.

b The Key Laboratory of Developmental Genes and Human Disease , Institute of Life Sciences, Southeast University , Nanjing , Jiangsu , China.

Notwithstanding the numerous drugs available for liver cancer, emerging evidence suggests that chemotherapeutic resistance is a significant issue. HGF and its receptor MET play critical roles in liver carcinogenesis and metastasis, mainly dependent on the activity of receptor tyrosine kinase. However, for unknown reasons, all HGF-MET kinase activity-targeted drugs have failed or have been suspended in clinical trials thus far. Read More

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http://dx.doi.org/10.1080/15548627.2019.1580105DOI Listing
February 2019

Clonal expansion of hepatic progenitor cells and differentiation into hepatocyte-like cells.

Dev Growth Differ 2019 Feb 20. Epub 2019 Feb 20.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatic progenitor cells (HPCs) in adult liver are promising for treatment of liver diseases. A biliary-derived HPC population in adult mice has been characterized by co-expression of stem cell marker Sry (sex determining region Y)-box 9 (SOX9) and biliary marker cytokeratin 7 (CK7). However, isolation of these HPCs in adult healthy liver without any selection procedures remains a big challenge in this field. Read More

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http://doi.wiley.com/10.1111/dgd.12596
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http://dx.doi.org/10.1111/dgd.12596DOI Listing
February 2019
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Novel fine gauge electrocautery dilator for EUS-guided hepaticogastrostomy (with video).

J Hepatobiliary Pancreat Sci 2019 Feb 20. Epub 2019 Feb 20.

Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.

Endoscopic ultrasound-guided biliary drainage (EUS-BD) has been emerged as an alternative drainage technique for ERCP [1-3]. To date, various techniques regarding tract dilation have been reported including graded, balloon or electrocautery dilation. To prevent bile leak during EUS-BD, simple dilation technique may be impact. Read More

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http://dx.doi.org/10.1002/jhbp.609DOI Listing
February 2019

Evaluation of hemostasis in patients with end-stage renal disease.

PLoS One 2019 20;14(2):e0212237. Epub 2019 Feb 20.

Department of General, Visceral and Transplant Surgery, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

An increased bleeding risk is reported for patients with end-stage renal disease. This study aims to analyze, whether bleeding risk can be assessed by global tests of hemostasis. Standard laboratory tests and an extended evaluation of hemostasis by rotational thromboelastometry, platelet function analyzer (PFA) and multiple electrode aggregometry as well as thrombin generation assays and measurement of fibrinolytic potential were performed in 20 patients on hemodialysis, 10 patients on peritoneal dialysis, 10 patients with chronic kidney disease stage G5 (CKD5) and in 10 healthy controls (HC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212237PLOS
February 2019

CCL21-expression and accumulation of CCR7 NK cells in livers of patients with primary sclerosing cholangitis.

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Research Department of Virus Immunology, Heinrich Pette Institute, Hamburg, Germany.

The pathogenesis of primary sclerosing cholangitis (PSC), an autoimmune liver disease, remains unknown. The aim of this study was to characterize peripheral blood and intrahepatic NK cells from patients with PSC. Peripheral blood samples from patients with PSC, other autoimmune liver diseases, and from healthy control individuals were used, as well as liver tissues from PSC patients undergoing liver transplantation. Read More

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http://dx.doi.org/10.1002/eji.201847965DOI Listing
February 2019

DIGESTIVE DISEASES IN ELDERLY AND FACTORS ASSOCIATED WITH LENGTH OF STAY IN THE HEPATOLOGY AND GASTROENTEROLOGY UNIT OF THE CAMPUS TEACHING HOSPITAL OF LOME (TOGO).

Arq Gastroenterol 2018 Oct-Dec;55(4):369-374

Hepatology and Gastroenterology Unit of the Campus Teaching Hospital of Lome, Togo.

Background: The digestive pathologies are frequent in the elderly and often have a latent and atypical symptomatology.

Objective: To assess the epidemiological and evolutionary current data on digestive diseases in the elderly, and look for factors associated with length of hospital stay.

Methods: Retrospective study of 10 years, including patients aged 60 and over hospitalized for digestive diseases in the Gastroenterology Department of the Campus Teaching Hospital of Lome, Togo. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-80DOI Listing

Swertiamarin decreases lipid accumulation dependent on 3-ketoacyl-coA thiolase.

Biomed Pharmacother 2019 Feb 19;112:108668. Epub 2019 Feb 19.

Hepatobiliary and Enteric Surgery Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Natural compounds are important resources for drug discovery. Using Caenorhabditis elegans (C. elegans) models, we screened active natural compounds with lipid lowering effects. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108668DOI Listing
February 2019

Using natural language processing to extract clinically useful information from Chinese electronic medical records.

Int J Med Inform 2019 Apr 7;124:6-12. Epub 2019 Jan 7.

Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, Henan Key Laboratory of Genetic Diseases and Functional Genomics, Henan Provincial People's Hospital of Henan University, Zhengzhou, Henan Province, PR China. Electronic address:

Aims: To develop a natural language processing (NLP)-based algorithm for extracting clinically useful information for patients with hepatocellular carcinoma (HCC) from Chinese electronic medical records (EMRs) and use these data for the assessment of HCC staging.

Materials And Methods: Clinical documents, including operation notes, radiology and pathology reports, of 92 HCC patients were collected from Chinese EMRs. We randomly grouped these patients into training (n = 60) and testing (n = 32) datasets. Read More

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http://dx.doi.org/10.1016/j.ijmedinf.2019.01.004DOI Listing

Enhanced expression of ten-eleven translocation 1 reverses gemcitabine resistance in cholangiocarcinoma accompanied by a reduction in P-glycoprotein expression.

Cancer Med 2019 Feb 19. Epub 2019 Feb 19.

Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Increasing evidence revealed that ten-eleven translocation 1 (TET1) plays an important role in tumorigenesis and chemoresistance, but its functions in gemcitabine resistance in cholangiocarcinoma (CCA) remain unknown. This study aims to investigate the effect of TET1 on gemcitabine resistance in CCA and the possible effect on P-glycoprotein (P-gp) expression encoded by multidrug resistance (MDR) genes. We established two kinds of gemcitabine-resistant CCA cell lines and confirmed its specific features. Read More

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http://dx.doi.org/10.1002/cam4.1983DOI Listing
February 2019

Clinical significance of low transaminase levels in children with inflammatory bowel disease.

World J Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Pediatric Gastroenterology Hepatology and Nutrition, Faculty of Medicine, Manisa Celal Bayar University, Manisa, Turkey.

Background: Low alanine aminotransaminase (LALT) levels may be seen in patients with inflammatory bowel disease (IBD), but there has been no study about the frequency and its clinical significance. We aimed to analyze the frequency of LALT, and its clinical significance in children with IBD.

Methods: The study included the 89 patients with IBD without hepatobiliary involvement. Read More

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http://dx.doi.org/10.1007/s12519-019-00235-5DOI Listing
February 2019

Bouveret's syndrome: A rare presentation of gastric outlet obstruction.

Exp Ther Med 2019 Mar 3;17(3):1813-1816. Epub 2019 Jan 3.

Department of Hepatobiliary Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, P.R. China.

Bouveret's syndrome refers to gastric outlet obstruction caused by the formation of a cholecystoduodenal fistula with subsequent migration and impaction of a large gallstone into the duodenum. A case of a 59-year-old male who presented to our institution with consistent abdominal pain and nausea is reported herein. Bouveret's syndrome was diagnosed after conducting a computed tomography scan. Read More

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http://dx.doi.org/10.3892/etm.2019.7150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364238PMC

Primary Versus Delayed Primary Incision Closure in Contaminated Abdominal Surgery: A Meta-Analysis.

J Surg Res 2019 Feb 19;239:22-30. Epub 2019 Feb 19.

Department of Thyroid and Breast Surgery, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China. Electronic address:

Background: Debates still exist whether delayed primary incision closure (DPC) could bring more benefits to patients suffering contaminated abdominal surgery. So, we want to determine whether DPC has advantage over primary incision closure (PC) in contaminated abdominal surgery.

Methods: Embase, Medline, and the Cochrane Library databases were searched for eligible studies from January 1, 1980 to August 6, 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193005
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http://dx.doi.org/10.1016/j.jss.2019.01.047DOI Listing
February 2019
1 Read

Modified laparoscopic choledocholithotomy T-tube drainage reduces the risk of bile leakage: A surgeon's experience.

Asian J Surg 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Molecular Pathology, Inner Mongolia Medical University, #5, Xin Hua Street, Huhhot 010059, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2019.01.001DOI Listing
February 2019

The role of lactate deshydrogenase levels on non-small cell lung cancer prognosis: a meta-analysis.

Cell Mol Biol (Noisy-le-grand) 2019 Jan 31;65(1):89-93. Epub 2019 Jan 31.

Department of Anesthesiology, No. 971 Hospital of PLA, Qingdao 266071, Shandong, China.

The role of serum lactate dehydrogenase (LDH) on the clinical outcomes of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) treatment remained to be elucidated. Therefore, we did this meta-analysis. We searched databases including PubMed, EMBASE, and Cochrane Library till to June, 2017. Read More

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January 2019

[mRNA expression of MDR3 gene in the blood of preterm infants with parenteral nutrition-associated cholestasis].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Feb;21(2):125-130

Department of Neonatology, Zhongshan Hospital Affiliated to Sun Yat-sen University, Zhongshan, Guangdong 528403, China.

Objective: To study the association between the expression of the MDR3 gene and the pathogenesis of parenteral nutrition-associated cholestasis (PNAC) in preterm infants.

Methods: Among the preterm infants who were admitted to the hospital from June 2011 to November 2017 and received parenteral nutrition for more than 14 days, 80 who did not develop PNAC were enrolled as non-PNAC group, and 76 who developed PNAC were enrolled as PNAC group. On days 1, 14, 30, 60 and 90 after birth, serum hepatobiliary biochemical parameters [alanine aminotransferase (ALT), total bilirubin (TBil), direct bilirubin (DBil), total bile acid (TBA) and gamma-glutamyl transpeptidase (γ-GT)], fibrosis indices [hyaluronic acid, laminin, procollagen III N-terminal peptide and type IV collagen] and clinical manifestations were observed. Read More

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February 2019

A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis.

Mol Cancer 2019 Feb 19;18(1):28. Epub 2019 Feb 19.

Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, 710061, Shaanxi Province, China.

Background: Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been revealed to be implicated in the carcinogenesis and progression of HCC. However, the expressions, clinical significances, and roles of most lncRNAs in HCC are still unknown. Read More

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http://dx.doi.org/10.1186/s12943-019-0957-7DOI Listing
February 2019

IL-21 reinvigorates exhausted natural killer cells in patients with HBV-associated hepatocellular carcinoma in STAT1-depedent pathway.

Int Immunopharmacol 2019 Feb 16;70:1-8. Epub 2019 Feb 16.

Department of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China. Electronic address:

Hepatocellular carcinoma (HCC) is the most common liver malignancy with dismal prognosis and limited treatment options. Natural killer (NK) cells are critical components of antitumor immunity due to their capacity to eliminate MHC class I-deficient cells. To evaluate the function of NK cells in HCC patients, circulating CD3CD56 NK cells were collected from HBV-associated HCC patients and healthy control individuals. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.007DOI Listing
February 2019

Methane alleviates sepsis-induced injury by inhibiting pyroptosis and apoptosis in vivo and in vitro experiments.

Aging (Albany NY) 2019 Feb 18. Epub 2019 Feb 18.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, People's Republic of China.

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. Methane has been reported to have anti-oxidative, anti-apoptotic and anti-inflammatory properties. We investigated the potential protective effects of methane on sepsis-induced injury and determined the related mechanisms. Read More

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http://dx.doi.org/10.18632/aging.101831DOI Listing
February 2019

Distribution of serum neuron-specific enolase and the establishment of a population reference interval in healthy adults.

J Clin Lab Anal 2019 Feb 19:e22863. Epub 2019 Feb 19.

Department of Laboratory Medicine, The Second People's Hospital of Lianyungang, Lianyungang, China.

Background: Neuron-specific enolase (NSE) is an important tumor marker in the serum of patients with lung cancer. Elevated serum NSE levels are also associated with many other diseases. However, there is no unified population reference interval for serum NSE. Read More

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http://dx.doi.org/10.1002/jcla.22863DOI Listing
February 2019
1.144 Impact Factor

LncRNA 00152 promotes the development of hepatocellular carcinoma by activating JAK2/STAT3 pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1038-1046

Department of Hepatobiliary Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Objective: The aim of this study was to explore the regulatory role of lncRNA 00152 and JAK2/STAT3 pathway in the pathogenesis of hepatocellular carcinoma (HCC), and to investigate the possible underlying mechanism.

Patients And Methods: Expression levels of lncRNA 00152 in HCC tissues, matched para-cancerous tissues and normal liver tissues were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR), respectively. The correlation between lncRNA 00152 expression and pathological characteristics of HCC patients was analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16991DOI Listing
February 2019

Clinical impact of circulating LAPTM4B-35 in pancreatic ductal adenocarcinoma.

J Cancer Res Clin Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of General, Visceral and Transplantation Surgery, University Hospital Muenster, Albert-Schweitzer-Campus 1 (W1), 48149, Münster, Germany.

Purpose: LAPTM4B is upregulated in a wide range of cancers associated with poor prognosis. However, the clinical impact of LAPTM4B as diagnostic and prognostic marker in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Thus, the aim of the present study was to investigate the expression of LAPTM4B as circulating marker in PDAC. Read More

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http://dx.doi.org/10.1007/s00432-019-02863-wDOI Listing
February 2019

Precancer antiviral treatment reduces microvascular invasion of early-stage Hepatitis B-related hepatocellular carcinoma.

Sci Rep 2019 Feb 18;9(1):2220. Epub 2019 Feb 18.

Department of Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, 200438, PR China.

The impact of antiviral therapy before tumorigenesis on microvascular invasion (MVI) of Chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC) is still unknown. In this retrospective cohort study 3,276 HCC patients with early-stage who underwent curative resection were included. We investigated the effect of precancer antiviral therapy on the pathology, especially MVI, of CHB-related HCC. Read More

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http://dx.doi.org/10.1038/s41598-019-39440-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379412PMC
February 2019

Clinical significance of galectin-3 expression in malformed hepatic venous tissue.

Indian J Med Res 2018 Dec;148(6):728-733

Department of Ophthalmology, Henan Eye Institute & Henan Provincial Eye Hospital, Zhengzhou, Henan, PR China.

Background & Objectives: Hepatic venous malformation gradually develops over time and exhibits the malignant biological behaviours of being locally invasive, causing morphological and functional damage to local tissue, and may even cause systemic coagulopathy. Studies show that galectin-3(Gal-3) expression is closely associated with local invasion of malignant tumours. In this study an attempt was made to assess the clinical significance of Gal-3 in local invasion during hepatic venous malformation in patients. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_500_17DOI Listing
December 2018

What should be known prior to performing EUS?

Endosc Ultrasound 2019 Jan-Feb;8(1):3-16

Department of Internal Medicine, Krankenhaus Maerkisch-Oderland, D-15344 Strausberg and Brandenburg Institute of Clinical Ultrasound at Medical University Brandenburg, Germany.

Direct referral of patients for EUS - instead of preprocedural consultation with the endosonographer - has become standard practice (like for other endoscopic procedures) as it is time- and cost-effective. To ensure appropriate indications and safe examinations, the endosonographer should carefully consider what information is needed before accepting the referral. This includes important clinical data regarding relevant comorbidities, the fitness of the patient to consent and undergo the procedure, and the anticoagulation status. Read More

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http://dx.doi.org/10.4103/eus.eus_54_18DOI Listing
February 2019

Bufalin induces apoptosis via mitochondrial ROS-mediated caspase-3 activation in HCT-116 and SW620 human colon cancer cells.

Drug Chem Toxicol 2019 Feb 19:1-7. Epub 2019 Feb 19.

a Institute of Hepatobiliary Surgery, Southwest Hospital , Third Military Medical University (Army Medical University) , Chongqing , China.

Objective: Bufalin has been reported to kill various types of cancer including human colorectal cancer. Our previous study demonstrated that bufalin induced cell death via autophagy in HT-29 and Caco-2 colon cancer cells, but the action of bufalin remains unclear. This study was conducted to investigate the role of bufalin in other colon cancer HCT-116 and SW620 cells as well as its potential mechanism. Read More

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http://dx.doi.org/10.1080/01480545.2018.1512611DOI Listing
February 2019

Ultrasound guided continuous Quadratus Lumborum block hastened recovery in patients undergoing open liver resection: a randomized controlled, open-label trial.

BMC Anesthesiol 2019 Feb 18;19(1):23. Epub 2019 Feb 18.

Department of Anesthesiology, The Second Xiangya Hospital of Central South University, 139 Renmin Middle Road, Hunan, China.

Background: Quadratus lumborum (QL) block is increasingly being used as a new abdominal nerve block technique. In some studies of mid and lower abdominal and hip analgesia, continuous QL block achieved favorable outcomes as an alternative to continuous intravenous analgesia with opioids. However, the use of continuous QL block for upper abdominal pain is less well characterized. Read More

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http://dx.doi.org/10.1186/s12871-019-0692-zDOI Listing
February 2019

Policies towards DCD liver transplantation: a need for a guideline?

J Hepatobiliary Pancreat Sci 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Division of Hepatopancreatobiliary and Transplant Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: Liver transplantation (LT) using grafts from donation after circulatory death (DCD) is evolving to standard of care in many countries. Various transplant centers have developed a protocol for DCD-LT. The existence of numerous protocols may cause inconsistencies. Read More

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http://doi.wiley.com/10.1002/jhbp.614
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http://dx.doi.org/10.1002/jhbp.614DOI Listing
February 2019
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Reduction of intrapancreatic neural density in cancer tissue predicts poorer outcome in pancreatic ductal carcinoma.

Cancer Sci 2019 Feb 18. Epub 2019 Feb 18.

Gastric Surgery Division, National Cancer Center Hospital, Tokyo.

Neural invasion is one of the malignant features contributing to locally advanced and/or metastatic disease progression in patients with pancreatic ductal adenocarcinoma (PDAC). Few studies exist about the distribution and state of nerve fibers in PDAC tissue and about their clinicopathological impacts. The aim of this study was to investigate the clinicopathological characteristics and prognostic value of intrapancreatic neural alterations in patients with PDAC. Read More

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http://dx.doi.org/10.1111/cas.13975DOI Listing
February 2019

Endoscopic versus Surgical Intervention for Jejunal Bezoar Formation.

ACG Case Rep J 2018 5;5:e87. Epub 2018 Dec 5.

Division of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Westchester Medical Center, Valhalla, NY.

Bezoar-induced small bowel obstruction is a rare entity, but it should be highly suspected in those with prior abdominal or bariatric surgery. The cornerstone of treatment for intestinal bezoars has been surgical exploration to relieve the obstruction. We present a patient with obstructive jejunal phytobezoar formation that was relieved via an endoscopic approach rather than a surgical modality. Read More

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http://dx.doi.org/10.14309/crj.2018.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358576PMC
December 2018

Exosome Release Is Regulated by mTORC1.

Adv Sci (Weinh) 2019 Feb 11;6(3):1801313. Epub 2018 Dec 11.

Department of Cell Biology Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China.

Exosomes are small membrane-bound vesicles released into extracellular spaces by many types of cells. These nanovesicles carry proteins, mRNA, and miRNA, and are involved in cell waste management and intercellular communication. In the present study, it is shown that exosome release, which leads to net loss of cellular membrane and protein content, is negatively regulated by mechanistic target of rapamycin complex 1 (mTORC1). Read More

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http://dx.doi.org/10.1002/advs.201801313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364500PMC
February 2019

Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1.

Onco Targets Ther 2019 29;12:869-882. Epub 2019 Jan 29.

Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China,

Background: Several studies have found that centromere protein K (CENPK) is overexpressed in several tumour types and promotes tumor progression. However, there has been little research on the role of CENPK in the progression of hepatocellular carcinoma (HCC).

Materials And Methods: The expression of CENPK in HCC tissues was quantified by Western blot and quantitative real-time PCR. Read More

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http://dx.doi.org/10.2147/OTT.S190061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357898PMC
January 2019

Analysis of intrahepatic sarcomatoid cholangiocarcinoma: Experience from 11 cases within 17 years.

World J Gastroenterol 2019 Feb;25(5):608-621

Department of Internal Medicine, Dong-A University College of Medicine, Busan 49201, South Korea.

Background: Intrahepatic sarcomatoid chonalgiocarcinoma (s-CCC) is an extremely rare disease, accounting for less than 1% of hepatobiliary system malignancies, and its pathophysiology is not well known. On the hypothesis that its clinical, serologic, or radiologic diagnosis are not fully understood and its prognosis is poor, we investigated the distinguishing features of s-CCC compared with those of intrahepatic bile duct adenocarcinoma [cholangiocellular carcinoma (CCC)] in patients from a single center.

Aim: To analyze the clinical, serologic, imaging, and histopathologic characteristics of intrahepatic s-CCC patients diagnosed in a single center. Read More

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http://dx.doi.org/10.3748/wjg.v25.i5.608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371010PMC
February 2019

Upregulated LncRNA-CCAT1 promotes hepatocellular carcinoma progression by functioning as miR-30c-2-3p sponge.

Cell Biochem Funct 2019 Feb 18. Epub 2019 Feb 18.

Department of Hepatobiliary Surgical, First Hospital of Jiaxing, Jiaxing, China.

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death over the world. It is well studied that long noncoding RNA colon cancer-associated transcript-1 (CCAT1) played important roles in variety of cancers promoting cell proliferation and metastasis by acting as a competing endogenous RNA (ceRNA) of microRNAs. However, whether CCAT1 could regulate HCC by serving as a ceRNA of microRNA remains to be revealed. Read More

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http://dx.doi.org/10.1002/cbf.3375DOI Listing
February 2019