33,448 results match your criteria Hepatobiliary & Pancreatic Diseases International HBPD Int[Journal]


Quantitative assessment of liver function using hepatobiliary scintigraphy: the effect of microcirculatory alterations after portal vein embolization.

Nucl Med Commun 2019 Apr 16. Epub 2019 Apr 16.

Departments of Surgery.

Objectives: Hepatobiliary scintigraphy using technetium-99m mebrofenin has been validated as a quantitative liver function test. Preoperative portal vein embolization (PVE) is performed in patients to increase future remnant liver function and volume. Changes in hepatic microcirculation after PVE remain largely unknown and may influence the uptake of mebrofenin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNM.0000000000001012DOI Listing

Adverse Outcomes After Bile Spillage in Incidental Gallbladder Cancers: A Population-based Study.

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Surgery, University of Calgary, Calgary, Alberta, Canada.

Objective: To determine the effect of bile spillage during cholecystectomy on oncological outcomes in incidental gallbladder cancers.

Background: Gallbladder cancer (GBC) is rare, but lethal. Achieving complete resection offers the best chance of survival. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SLA.0000000000003325DOI Listing

Case 265: Lemmel Syndrome or Biliary Obstruction Due to a Periampullary Duodenal Diverticulum.

Radiology 2019 May;291(2):542-545

From the Department of Diagnostic Radiology, Singapore General Hospital, Outram Road, Singapore 169608.

History A 70-year-old man presented to the emergency department with fever, chills, rigors, and upper abdominal discomfort. Physical examination revealed jaundice and mild right upper quadrant tenderness. Laboratory tests revealed an increased C-reactive protein level of 133 mg/L (normal range, 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/radiol.2019162375DOI Listing

Overexpression of MTHFD1 in hepatocellular carcinoma predicts poorer survival and recurrence.

Future Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, 200438, PR China.

MTHFD1 was the enzyme providing one-carbon derivatives of tetrahydrofolate. We sought to investigate the impact of MTHFD1 on hepatocellular carcinoma (HCC). Bioinformatic analysis, western blot and immunohistochemistry were conducted to detect MTHFD1 expression in HCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon-2018-0606DOI Listing

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Klinikum rechts der Isar, The Technical University of Munich, Munich, Germany.

Hepatocellular carcinoma (HCC) is a fatal disease with increasing morbidity and poor prognosis due to surgical recurrence and metastasis. Moreover, the molecular mechanism of HCC progression remains unclear. Although the role of p120-catenin (p120ctn) in liver cancer is well studied, the effects of secreted p120ctn transported by exosomes are less understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mc.23022DOI Listing

Prognostic utility and clinical significance of lysyl oxidase-like 2 protein expression in digestive system cancers.

J Cell Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Hepatobiliary Surgery, Meizhou People's Hospital, Meizhou, Guangdong, P. R. China.

Lysyl oxidase-like 2 (LOXL2) participates in the occurrence and development of digestive system cancers (DSCs). The aim of this study was to determine whether LOXL2 protein could serve as a prognostic biomarker in patients with DSCs. Relevant studies published before October 1, 2018 were identified from a comprehensive literature review in PubMed, Web of Science, and Embase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28677DOI Listing

Foreword.

Hepatobiliary Surg Nutr 2019 Mar;8(Suppl 1):S1

Director, Distinguished Investigator, National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan. (Email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/hbsn.2019.02.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421207PMC

Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma.

Clin Chem 2019 Apr 17. Epub 2019 Apr 17.

MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China;

Background: Reliable noninvasive biomarkers for hepatocellular carcinoma (HCC) diagnosis and prognosis are urgently needed. We explored the potential of not only microRNAs (miRNAs) but other types of noncoding RNAs (ncRNAs) as HCC biomarkers.

Methods: Peripheral blood samples were collected from 77 individuals; among them, 57 plasma cell-free RNA transcriptomes and 20 exosomal RNA transcriptomes were profiled. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1373/clinchem.2018.301150DOI Listing

Hepatorenal Syndrome.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Division of Nephrology and Hypertension, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California

Hepatorenal syndrome is a severe complication of end-stage cirrhosis characterized by increased splanchnic blood flow, hyperdynamic state, a state of decreased central volume, activation of vasoconstrictor systems, and extreme kidney vasoconstriction leading to decreased GFR. The contribution of systemic inflammation, a key feature of cirrhosis, in the development of hepatorenal syndrome has been highlighted in recent years. The mechanisms by which systemic inflammation precipitates kidney circulatory changes during hepatorenal syndrome need to be clarified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2215/CJN.12451018DOI Listing

Biliary dilatation in a 67-year-old woman: seeing is believing.

Gut 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai, China.

View Article

Download full-text PDF

Source
http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-318200
Publisher Site
http://dx.doi.org/10.1136/gutjnl-2018-318200DOI Listing
April 2019
1 Read

Vascular Anomalies of the Extrahepatic Artery as a Predictable Risk Factor for Complications After Liver Transplant.

Exp Clin Transplant 2019 Apr 17. Epub 2019 Apr 17.

From the Department of Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: Vascular variations of the extrahepatic artery occur in up to 50% of the population. Exact knowledge of any anomalies is of great significance in hepatobiliary surgery to avoid perioperative complications. In fact, in liver transplant, vascular complications are rare but have a major impact on graft function and survival. Read More

View Article

Download full-text PDF

Source
http://www.ectrx.org/detail/epub/1/1/1/0/796/0
Publisher Site
http://dx.doi.org/10.6002/ect.2018.0201DOI Listing
April 2019
1 Read

Review of hepatobiliary contrast agents: Current applications and challenges.

Clin Liver Dis (Hoboken) 2018 Jan 31;11(1):22-26. Epub 2018 Jan 31.

University of Lübeck Campus Lübeck Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cld.688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385936PMC
January 2018

Gamma-glutamyl transferase as a risk factor for mortality and cardiovascular events in older adults - results from a prospective cohort study in a primary care setting (getABI).

Vasa 2019 Apr 17:1-7. Epub 2019 Apr 17.

1 Department of Medical Informatics, Biometry and Epidemiology, Ruhr University Bochum, Bochum, Germany.

In primary care, the gamma-glutamyl transferase (GGT) activity is used for assessing hepatobiliary dysfunction, but is also known to be associated with the risk of cardiovascular events as well as overall mortality. As this knowledge is mainly based on cohorts with middle-aged participants, we aim to assess these associations in elderly patients in a primary care setting. 6,880 unselected primary care patients, aged 65 years or older, were enrolled by 344 general practitioners all over Germany (getABI study). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1024/0301-1526/a000790DOI Listing

Evaluation of a new robotic-assisted laparoscopic surgical system for procedures in small cavities.

J Robot Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio, Chieti-Pescara, Italy.

No data exists concerning the application of a new robotic system with 3-mm instruments (Senhance™, Transenterix, Milano, Italy) in small cavities. Therefore, the aim of this study was to test the system for its performance of intracorporal suturing in small boxes simulating small body cavities. Translucent plastic boxes of decreasing volumes (2519-90 ml) were used. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11701-019-00961-y
Publisher Site
http://dx.doi.org/10.1007/s11701-019-00961-yDOI Listing
April 2019
1 Read

Hepatic pleomorphic leiomyosarcoma after surgery for gastric gastrointestinal stromal tumor: a case report.

Surg Case Rep 2019 Apr 16;5(1):62. Epub 2019 Apr 16.

Department of General Surgical Science, Division of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Gunma University, 3-39-22 Showa-Machi, Maebashi, Gunma, 371-8511, Japan.

Background: Pleomorphic leiomyosarcomas (PLMSs) are extremely rare tumors. We present the first case of hepatic primary PLMS after surgery for gastric gastrointestinal stromal tumor (GIST).

Case Presentation: The patient was a 62-year-old man who was referred to our hospital for resection of a hepatic tumor arising after gastric GIST surgery that was resistant to imatinib and sunitinib. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40792-019-0622-9DOI Listing

Lipiodol deposition in portal vein tumour thrombus predicts treatment outcome in HCC patients after transarterial chemoembolisation.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, 510060, China.

Objective: To study lipiodol deposition in portal vein tumour thrombus (PVTT) in predicting the treatment outcome of hepatocellular carcinoma (HCC) patients after transarterial chemoembolisation (TACE).

Methods: We retrospectively reviewed data from 379 HCC patients with PVTT who underwent TACE as the initial treatment at Sun Yat-Sen University Cancer Center from January 2008 to December 2015. Patients were grouped by positive and negative lipiodol deposition based on the extent of lipiodol deposition in PVTT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06157-0DOI Listing

MRI for characterization of benign hepatocellular tumors on hepatobiliary phase: the added value of in-phase imaging and lesion-to-liver visual signal intensity ratio.

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastrointestinal Imaging, Lille University Hospital, Rue Michel Polonovski, 59037, Lille Cedex, France.

Objectives: To evaluate the lesion-to-liver visual signal intensity ratio (SIR) before and at the hepatobiliary phase MRI (HBP-MRI) after gadobenate dimeglumine (Gd-BOPTA) injection, using several T1-weighted images (T1-WI), for the characterization of benign hepatocellular lesions.

Methods: Patients with histologically proven focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA), who underwent Gd-BOPTA-enhanced HBP-MRI from 2009 to 2017, were retrospectively identified. The lesion-to-liver SIR was visually assessed by two radiologists on HBP (post-HBP analysis) and compared with that of unenhanced sequences (pre/post-HBP analysis) on T1-WI in-phase (T1-IP), out-of-phase (T1-OP), and fat suppression (T1-FS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-019-06210-yDOI Listing

Evaluating the learning curve for laparoscopic liver resection: a comparative study between standard and learning curve CUSUM.

HPB (Oxford) 2019 Apr 13. Epub 2019 Apr 13.

Department of HPB Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. Electronic address:

Background: Laparoscopic liver resection (LLR) requires training in both hepatobiliary surgery and advanced laparoscopy. Available data on LLR learning curves are derived from pioneer surgeons. The aims of this study were to evaluate the LLR learning curve for second generation surgeons, and to compare different CUSUM methodology with and without risk adjustment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hpb.2019.03.362DOI Listing

Elimination Pathways of Nanoparticles.

ACS Nano 2019 Apr 16. Epub 2019 Apr 16.

Understanding how nanoparticles are eliminated from the body is required for their successful clinical translation. Many promising nanoparticle formulations for in vivo medical applications are large (>6 nm) and non-biodegradable, so they cannot be eliminated renally. A proposed pathway for these nanoparticles is hepatobiliary elimination, but their transport has not been well-studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.9b01383DOI Listing

Gadoxetic Acid-enhanced MRI of Hepatocellular Carcinoma: Value of Washout in Transitional and Hepatobiliary Phases.

Radiology 2019 Apr 16:182587. Epub 2019 Apr 16.

From the Department of Radiology and Research Institute of Radiology (D.H.K., S.H.C., S.Y.K., S.S.L., J.H.B.) and Department of Clinical Epidemiology and Biostatistics (M.J.K.), University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Republic of Korea.

Background Current Liver Imaging Reporting and Data System guidelines define the washout appearance of gadoxetic acid-enhanced MRI only during the portal venous phase. Defining washout only during the portal venous phase may lead to lower sensitivity for diagnosis of hepatocellular carcinoma (HCC). Purpose To compare the diagnostic performances of three gadoxetic acid-enhanced MRI criteria fono. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/radiol.2019182587DOI Listing

[Inhibitory effect of flavonoids from Scutellariae Radix on human cytochrome P450 1A].

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):566-573

Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine Shanghai 201210, China.

This study investigated the inhibitory effect of eight natural flavonoids in Chinese herb Scutellariae Radix on huamn cytochrome P450 1 A(CYP1 A), a key cancer chemo-preventive target. In this study, phenacetin was used as a probe substrate for CYP1 A, while human liver microsomes and recombinant human CYP1 A enzymes were used as enzyme sources. Liquid chromatography-tandem mass spectrometry was used to monitor the formation rates of acetaminophen, the O-deethylated metabolite of phenacetin. Read More

View Article

Download full-text PDF

Source
http://www.cnki.net/kcms/doi/10.19540/j.cnki.cjcmm.20181128.
Publisher Site
http://dx.doi.org/10.19540/j.cnki.cjcmm.20181128.005DOI Listing
February 2019
1 Read

A systematic review and meta-analysis comparing the short- and long-term outcomes for laparoscopic and open liver resections for liver metastases from colorectal cancer.

Surg Endosc 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepato-Biliary and Pancreatic Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Background: The laparoscopic approach to liver resection has experienced exponential growth in recent years. However, evidence-based guidelines are needed for its safe future progression. The main aim of our study was to perform a systematic review and meta-analysis comparing the short- and long-term outcomes of laparoscopic and open liver resections for colorectal liver metastases (CRLM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00464-019-06774-2DOI Listing

Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast-enhanced ultrasonography and ultrasound elastography.

Exp Ther Med 2019 May 6;17(5):3655-3663. Epub 2019 Mar 6.

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

The purpose of the present study was to investigate whether contrast-enhanced ultrasonography (CEUS) in combination with ultrasound elastography (UE) is able to accurately predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients. A total of 65 breast cancer patients who received NAC at the First Affiliated Hospital of Zhejiang University (Hangzhou, China) between February 2016 and August 2017 and were recruited for the present study. Prior to and after NAC, examination by CEUS, UE or their combination was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.7353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447770PMC

LncRNA ZEB1-AS1 reduces liver cancer cell proliferation by targeting miR-365a-3p.

Exp Ther Med 2019 May 7;17(5):3539-3547. Epub 2019 Mar 7.

Department of Hepatobiliary Surgery, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China.

Liver carcinoma is one of the most common malignancies worldwide. Previous studies have demonstrated that long non-coding RNAs (lncRNAs) are crucial mediators that participate in a wide range of molecular processes associated with carcinogenesis. However, little is known about the specific mechanisms that underlie the majority of lncRNAs. Read More

View Article

Download full-text PDF

Source
http://www.spandidos-publications.com/10.3892/etm.2019.7358
Publisher Site
http://dx.doi.org/10.3892/etm.2019.7358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447761PMC
May 2019
1 Read

A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer.

Cancer Cell Int 2019 3;19:81. Epub 2019 Apr 3.

4Division of Surgical Oncology, Department of Surgery, University of Louisville, Louisville, KY 40202 USA.

Background: Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used in clinic for gastric cancer treatment but with toxic side effects and develops resistance. Anti-tumor properties of copper and its coordinated compounds have been explored intensively in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-019-0801-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448317PMC

LINC01296 promotes proliferation, migration, and invasion of HCC cells by targeting miR-122-5P and modulating EMT activity.

Onco Targets Ther 2019 26;12:2193-2203. Epub 2019 Mar 26.

National Key Clinical Department, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing 400000, People's Republic of China,

Introduction: Long noncoding RNAs (lncRNAs) play an important role in the origination and progression of hepatocellular carcinoma (HCC). However, the biological function of the long intergenic non-protein-coding RNA, LINC01296, in HCC remains unknown.

Methods: Here, we observed an increase in the expression levels of LINC01296 in HCC tissues and cell lines using reverse transcription quantitative PCR; these data were consistent with that obtained from The Cancer Genome Atlas database. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/linc01296-promotes-proliferation-m
Publisher Site
http://dx.doi.org/10.2147/OTT.S197338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441465PMC
March 2019
1 Read

RIPK1 and death receptor signaling drive biliary damage and early liver tumorigenesis in mice with chronic hepatobiliary injury.

Cell Death Differ 2019 Apr 15. Epub 2019 Apr 15.

Institute for Genetics, University of Cologne, D-50674, Cologne, Germany.

Hepatocyte apoptosis is intrinsically linked to chronic liver disease and hepatocarcinogenesis. Conversely, necroptosis of hepatocytes and other liver cell types and its relevance for liver disease is debated. Using liver parenchymal cell (LPC)-specific TGF-beta-activated kinase 1 (TAK1)-deficient (TAK1) mice, which exhibit spontaneous hepatocellular and biliary damage, hepatitis, and early hepatocarcinogenesis, we have investigated the contribution of apoptosis and necroptosis in hepatocyte and cholangiocyte death and their impact on liver disease progression. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41418-019-0330-9
Publisher Site
http://dx.doi.org/10.1038/s41418-019-0330-9DOI Listing
April 2019
2 Reads

Low tumour PPM1H indicates poor prognosis in colorectal cancer via activation of cancer-associated fibroblasts.

Br J Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, 168 Changhai Rd., Shanghai, 200433, China.

Background: Vimentin (VIM) is considered a prognostic marker in colorectal cancer (CRC). Our aim is to identify genes that fulfil a "X-low implies VIM-high" Boolean relationship and to evaluate their prognostic value and potential mechanism.

Methods: Potential biomarkers related to VIM expression were searched using a bioinformatics approach across gene-expression arrays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-019-0450-5DOI Listing

Blockade of miR-142-3p promotes anti-apoptotic and suppressive function by inducing KDM6A-mediated H3K27me3 demethylation in induced regulatory T cells.

Cell Death Dis 2019 Apr 15;10(5):332. Epub 2019 Apr 15.

Hepatobiliary Center, First Affiliated Hospital, Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, China.

In vitro induced human regulatory T cells (iTregs) have in vivo therapeutic utility. MicroRNAs (miRNAs) are a family of approximately 22-nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. miRNAs regulate post-transcriptional protein expression through messenger RNA destabilization or translational silencing; miR-142-3p regulates natural Treg function through autophagy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-019-1565-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465300PMC

Extrahepatic biliary tract angle is a risk factor for biliary tract injury in laparoscopic cholecystectomy: A surgeon's experience.

Asian J Surg 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology, The Affiliated People's Hospital of Inner Mongolia Medical University, Huhhot, 010010, PR China. Electronic address:

In our clinical work, we found that there is a certain angle in the extrahepatic biliary system, that is to say, there is an angle between the extension line of the lower common bile duct and the upper duodenal segment of bile duct system In Magnetic Resonance Cholangiopancreatography (MRCP), the angle of a patient with bile duct injury(BDI) during laparoscopic cholecystectomy (LC) was measured and compared with that of a patient without BDI during LC We suspect that the bigger angle may be related to the occurrence of BDI in LC We named the angle in the coronal and sagittal positions as "proximity angle" and "exposure angle" respectively. Our experience is that preoperative assessment of relevant angles may be helpful to avoid the occurrence of BDI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.asjsur.2019.03.010DOI Listing

Combined preoperative platelet-to-lymphocyte ratio and serum carbohydrate antigen 19-9 level as a prognostic factor in patients with resected pancreatic cancer.

Hepatobiliary Pancreat Dis Int 2019 Apr 5. Epub 2019 Apr 5.

Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago 683-8504, Japan.

Background: Carbohydrate antigen 19-9 (CA19-9) is the most frequently used tumor marker and serves as a prognostic indicator in patients with pancreatic cancer (PC). The platelet-to-lymphocyte ratio (PLR) is thought to be an inflammation-related serum marker. An elevated PLR represents increased inflammatory status and is associated with poor prognosis in patients with various cancers including PC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hbpd.2019.03.010DOI Listing

Outcomes of central hepatectomy versus extended hepatectomy.

Hepatobiliary Pancreat Dis Int 2019 Mar 26. Epub 2019 Mar 26.

Department of Surgery, University of Melbourne, Austin Health, Heidelberg, Melbourne, Victoria, Australia. Electronic address:

Background: Central hepatectomy (CH) is more difficult than extended hepatectomy (EH) and is associated with greater morbidity. In this modern era of liver management with aims to prevent post-hepatectomy liver failure (PHLF), there is a need to assess outcomes of CH as a parenchyma-sparing procedure for centrally located liver tumors.

Methods: A total of 178 major liver resections performed by specialist surgeons from two Australian tertiary institutions between June 2009 and March 2017 were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hbpd.2019.03.005DOI Listing

Combined treatment for solid pseudopapillary tumor of the pancreas with liver metastasis.

Hepatobiliary Pancreat Dis Int 2019 Apr 5. Epub 2019 Apr 5.

Key Laboratory of Digestive System Tumors of Gansu Province, Lanzhou 730000, China; Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14993872193006
Publisher Site
http://dx.doi.org/10.1016/j.hbpd.2019.04.002DOI Listing
April 2019
1 Read

Validation Study of Tumor Invasive Thickness for Postoperative Prognosis in 110 Patients Who Underwent Pancreatoduodenectomy for Distal Cholangiocarcinoma at a Single Institution.

Am J Surg Pathol 2019 May;43(5):717-723

Department of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine.

The pT classification of the 8th American Joint Committee on Cancer (AJCC) for distal cholangiocarcinoma (DCC) is classified according to depth of invasion (DOI), which is the distance from the basal lamina to the most deeply advanced tumor cells. The Nagoya group proposed a new T classification for DCC based on invasive tumor thickness (ITT), which is the maximal vertical distance of the invasive cancer component (the ITT grade). In this study, we aimed to validate the ITT grade for the next pT classification of DCC in 110 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PAS.0000000000001244DOI Listing

Trophodynamics and parabolic behaviors of polycyclic aromatic hydrocarbons in an urbanized lake food web, Shanghai.

Ecotoxicol Environ Saf 2019 Apr 12;178:17-24. Epub 2019 Apr 12.

Key Laboratory of Geographic Information Science of the Ministry of Education, School of Geographical Sciences, East China Normal University, Shanghai, 200241, China.

Understanding the trophic movement and trophic magnification factor (TMF) of polycyclic aromatic hydrocarbons (PAHs) is an important criterion to assess their fate and potential effects in an aquatic ecosystem. This study investigated concentrations and trophodynamics of 16 priority PAHs in food web (food web comprising whole bodies) and food web (food web containing only muscles) of total 14 species ((including plankton, shrimp, whitebait, mussels, snails, red-eared terrapin and seven other fish species) from the Dianshan Lake. Values of δC and δN were determined to assign trophic levels to organisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ecoenv.2019.04.003DOI Listing

Review of Cystic Fibrosis.

Pediatr Ann 2019 Apr;48(4):e154-e161

Cystic fibrosis (CF) is an autosomal recessive disease characterized by pancreatic insufficiency and chronic endobronchial airway infection. This latter feature results in progressive bronchiectasis and ultimately respiratory failure, which is the leading cause of death in patients with CF. Other complications include sinusitis, diabetes mellitus, bowel obstruction, hepatobiliary disease, hyponatremic dehydration, and infertility. Read More

View Article

Download full-text PDF

Source
https://www.healio.com/doiresolver?doi=10.3928/19382359-2019
Publisher Site
http://dx.doi.org/10.3928/19382359-20190327-01DOI Listing
April 2019
1 Read

MicroRNA-related transcription factor regulatory networks in human colorectal cancer.

Medicine (Baltimore) 2019 Apr;98(15):e15158

Department of Medical Research Center.

Objective: Colorectal cancer (CRC) is an extremely common gastrointestinal malignancy. The present study aimed to identify microRNAs (miRNAs) and transcription factors (TFs) associated with tumor development.

Methods: Three miRNA profile datasets were integrated and analyzed to elucidate the potential key candidate miRNAs in CRC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015158DOI Listing
April 2019
2 Reads

Strain histograms used for differential diagnosis of breast masses according to hardness percentage.

Medicine (Baltimore) 2019 Apr;98(15):e15125

Department of Special Diagnosis.

To evaluate the diagnostic performance of percentage of hard component (PHC) versus strain ratio (SR) in focal breast lesion diagnosis.Ultrasonography and elastography images of 245 malignant and 255 benign breast lesions were obtained and analyzed according to the Breast Imaging-Reporting and Data System of the American College of Radiology. PHC and SR were measured for each lesion and receiver operating characteristic (ROC) curve analysis was performed to evaluate and compare the diagnostic performance of conventional ultrasound (CU) only, PHC with CU, and SR with CU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015125DOI Listing
April 2019
1 Read

Segmental zoster abdominal paresis mimicking an abdominal hernia: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(15):e15037

Department of Hepatobiliary and Abdominal Hernias Surgery, Weihai Central Hospital, Weihai, Shandong Province, People's Republic of China.

Rationale: Herpes zoster infection typically involves the posterior root ganglia and most of the symptoms are sensory. Motor involvement can occur in the same distribution but is relatively uncommon. Segmental zoster paresis is a rare motor complication of Herpes zoster, mimicking an abdominal hernia, but it needs no surgery different from the real abdominal wall hernia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000015037DOI Listing

Pituitary Adenylate Cyclase-Activating Polypeptides Prevent Hepatocyte Damage by Promoting Yes-associated Protein in Liver Ischemia/Reperfusion Injury.

Transplantation 2019 Apr 8. Epub 2019 Apr 8.

Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.

Background: Hepatic ischemia-reperfusion injury (IRI) is a severe complication in liver transplantation, hepatectomy and hemorrhagic shock. As neuropeptides transmit the regulatory signal between nervous-immune systems communication, our previous study documented that pituitary adenylate cyclase-activating polypeptides (PACAP) depressed hepatic TLR4 immune response in liver IRI.

Methods: Here, we focused on how PACAP suppressed hepatocellular damage and enhanced hepatocyte regeneration in a murine model of partial liver warm IRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/TP.0000000000002742DOI Listing

LncRNA FENDRR represses proliferation, migration and invasion through suppression of survivin in cholangiocarcinoma cells.

Cell Cycle 2019 Apr 14:1-9. Epub 2019 Apr 14.

a Department of Hepatobiliary Surgery, Henan Provincial People's Hospital , People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University , Zhengzhou , Henan , China.

This study was to investigate the biological function and underlying mechanisms of FENDRR in cholangiocarcinoma (CCA) cell proliferation, migration and invasion. FENDRR and survivin expression in CCA tissues or cell lines were measured by qRT-PCR. In QBC939 and HuCCTl cells, cell proliferation was detected by CCK-8, cell migration and invasion were using transwell assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2019.1598726DOI Listing

siRNA-mediated silencing of PAI-1 gene acts as a promoter over the recanalization of endothelial progenitor cells in rats with venous thrombosis.

J Cell Physiol 2019 Apr 14. Epub 2019 Apr 14.

Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.

With the changing lifestyle, venous thrombosis (VT) is becoming increasingly prevalent and poses a burden on the health economy. Endothelial progenitor cells (EPCs) are recruited into resolving VT. We aimed to investigate the effect of plasminogen activator inhibitor 1 (PAI-1) silencing on the recanalization of VT in rat EPCs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28590DOI Listing

A nomogram to predict early postoperative recurrence of hepatocellular carcinoma with portal vein tumour thrombus after R0 liver resection: A large-scale, multicenter study.

Eur J Surg Oncol 2019 Apr 3. Epub 2019 Apr 3.

Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University Shanghai, China. Electronic address:

Background: Portal vein tumour thrombus (PVTT) is a significant poor prognostic factor for hepatocellular carcinoma (HCC). Patients with PVTT limited to a first-order branch or above of the main portal vein (MPV) could benefit from R0 liver resection (LR). A nomogram is needed to predict early postoperative recurrence (ER) in HCC patients with PVTT and to guide selection of these patients for adjuvant therapy to reduce postoperative recurrence risks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejso.2019.03.043DOI Listing

Long non-coding RNA MNX1-AS1 promotes hepatocellular carcinoma proliferation and invasion through targeting miR-218-5p/COMMD8 axis.

Biochem Biophys Res Commun 2019 Apr 11. Epub 2019 Apr 11.

Department of Breast Surgery, China-Japan Union Hospital of Jilin University, Changchun, 130033, China. Electronic address:

Long noncoding RNAs (lncRNAs) are involved in tumorigenesis. Previously, lncRNA MNX1-AS1 was reported to increase the malignancy of ovarian cancer, cervical cancer and lung cancer. However, the potential function of MNX1-AS1 in hepatocellular carcinoma (HCC) remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2019.04.012DOI Listing

The volume-time index (VTI) is prognostic in patients with colorectal cancer peritoneal metastases undergoing cytoreductive surgery and intraperitoneal chemotherapy.

Am J Surg 2019 Apr 1. Epub 2019 Apr 1.

Hepatobiliary and Surgical Oncology Unit, Department of Surgery, St George Hospital, Kogarah, NSW, Australia; St George Hospital Clinical School, University of New South Wales, Sydney, NSW, Australia. Electronic address:

Background: Peritoneal cancer index (PCI) is an important prognostic factor in colorectal cancer peritoneal metastases (CRPM), however it fails to consider the time period over which disease burden develops. The volume-time index (VTI) is the ratio between PCI and time from primary tumour resection.

Methods: A retrospective cohort study of 182 patients managed from 1996 to 2017 was performed. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00029610193015
Publisher Site
http://dx.doi.org/10.1016/j.amjsurg.2019.03.023DOI Listing
April 2019
1 Read

High blood miR-802 is associated with poor prognosis in HCC patients by regulating DNA damage response 1 (REDD1)-mediated function of T cells.

Oncol Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Hepatobiliary Pancreatic Surgery, First Hospital of Jilin University, Changchun 130021, China.

MiR-802 has been reported to be dysregulated in multiple tumors and contributed to tumor progression. However, its role in HCC was still largely unknown. The aim of this study is to investigate the function and mechanism of miR-802 in HCC progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3727/096504018X15456687424096DOI Listing

Expression of Interleukin-6 and Integrin ανβ6 in Colon Cancer: Association with Clinical Outcomes and Prognostic Implications.

Cancer Invest 2019 Apr 14:1-11. Epub 2019 Apr 14.

a Department of Gastrointestinal Surgery , Provincial Hospital Affiliated to Shandong University , Jinan , China.

As important factors in the tumor microenvironment, interleukin-6 (IL-6) and integrin ανβ6 play significant roles in accumulating mutations that drive the progression and metastatic capacities of cancer. The aim of this study was to investigate the expression of IL-6 and integrin ανβ6, their clinical significance, as well as their correlation in the colon cancer tissues of 145 cases using immunohistochemistry. Our results showed that IL-6 and integrin ανβ6 are indicators of cancer progression and poor prognosis in patients with colon cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/07357907.2019.1597103DOI Listing

miR-632 functions as oncogene in hepatocellular carcinoma via targeting MYCT1.

Hum Gene Ther Clin Dev 2019 Apr 15. Epub 2019 Apr 15.

Affiliated Hospital of Youjiang Medical University for Nationalities, Department of Pathology , Baise, Guangxi 533000, P. R. China , Baise, China , 533000 ;

microRNAs (miRNAs) have been widely recognized as crucial regulators for tumorigenesis. However, the role of miR-632 in hepatocellular carcinoma (HCC) remains largely unknown. miR-632 expression in HCC cell lines was determined by quantitative real-time PCR. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/humc.2019.040
Publisher Site
http://dx.doi.org/10.1089/humc.2019.040DOI Listing
April 2019
1 Read

Characterization of Intraductal Papillary Neoplasm of the Bile Duct with Respect to the Histopathologic Similarities to Pancreatic Intraductal Papillary Mucinous Neoplasm.

Gut Liver 2019 Apr 15. Epub 2019 Apr 15.

Department of Hepatobiliary Pancreatic Surgery, Shizuoka Cancer Center, Sunto, Japan.

Intraductal papillary neoplasms of the bile duct (IPNBs) are known to show various pathologic features and biological behaviors. Recently, two categories of IPNBs have been proposed based on their histologic similarities to pancreatic intraductal papillary mucinous neoplasms (IPMNs): type 1 IPNBs, which share many features with IPMNs; and type 2 IPNBs, which are variably different from IPMNs. The four IPNB subtypes were re-evaluated with respect to these two categories. Read More

View Article

Download full-text PDF

Source
http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl18
Publisher Site
http://dx.doi.org/10.5009/gnl18476DOI Listing
April 2019
3 Reads

Simple cholangitis induces extremely and recurrently elevated serum carbohydrate antigen 19-9 level.

Hepatobiliary Pancreat Dis Int 2019 Apr 5. Epub 2019 Apr 5.

Department of Hepatopancreatobiliary Surgery, Yin Zhou People's Hospital, Ningbo 315040, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hbpd.2019.03.008DOI Listing