10,031 results match your criteria Hepato-Gastroenterology[Journal]
Hepatogastroenterology 2015 Jun;62(140):1041-6
Background/aims: The aim of this study was to evaluate the surgical outcomes after palliative surgery for patients with incurable gastric cancer.
Methodology: This retrospective study included 45 patients with gastric outlet obstruction (GOO) who needed parental nutrition and 33 patients with anemia due to tumor bleeding who required blood transfusions. We compared the surgical outcomes of palliative gastrectomy (PG) and bypass surgery (BS) in each group. Read More
Hepatogastroenterology 2015 Jun;62(140):1037-40
Background/aims: Laparoscopic pancreaticoduodenectomy (LPD) is still a challenging operation, particularly because the dissection around the superior mesenteric artery (SMA) and bleeding control are difficult. Although it has been reported that early ligation of the origin of the inferior pancreaticoduodenal artery (IPDA) reduces blood loss, it is difficult to laparoscopically expose the origin of the IPDA. We sought to develop a novel approach to simplify the dissection of the IPDA and reduce bleeding. Read More
Hepatogastroenterology 2015 Jun;62(140):1031-6
Background/aims: To determine the recommended dose (RD) for full-dose S-1 and low-dose gemcitabine combined with radiotherapy in patients with non-metastatic advanced pancreatic cancer.
Methodology: Adult patients with non-metastatic advanced pancreatic cancer (Union for International Cancer Control T stage 3 or 4) were eligible. The weekly intravenous gemcitabine (level 0-1: 200 mg/ml,level 2: 300 mg/m on Days 1, 8, 15, 22, 29, 36) dose was escalated starting from level 1 in a 3+3 design along with full dose twice-daily oral S-1 (level 0: 60 mg/m2/day, level 1-2: 80 mg/ml/day), and was administered on the same days as radiotherapy (1. Read More
Hepatogastroenterology 2015 Jun;62(140):1027-31
Background/aims: Endoscopic papillary balloon dilation (EPBD) was reported to be superior for preserving the function of the sphincter of Oddi and to cause fewer late complications than endoscopic sphincterotomy. If the early complication of post-EPBD pancreatitis can be prevented, EPBD might be useful as long-term outcomes. This study assessed the feasibility of a novel EPBD for the purpose of reliable post-EPBD pancreatic stenting. Read More
Hepatogastroenterology 2015 Jun;62(140):1023-6
Background/aims: Cirrhotic patients admitted to the hospital have a high mortality rate. The aim of this study was to evaluate predictors of mortality in patients hospitalized for specific complications of cirrhosis.
Methodology: All patients admitted to the gastroenterology service with cirrhosis during a 2-year period were retrospectively identified. Read More
Hepatogastroenterology 2015 Jun;62(140):1016-22
In cirrhotic patients, portal hypertension is often associated with a hyperdynamic changes. Transjugular Intrahepatic Portosystemic Shunt (TIPS) and Laparoscopic splenectomy are both treatments for liver cirrhosis due to portal hypertension. While, the two different interventions have different effects on hemodynamics after operation and the possibilities of triggering PVT are different. Read More
Hepatogastroenterology 2015 Jun;62(140):1011-5
Background/aims: This study aimed to investigate the association between comorbidity, anti-cancer treatment, and overall survival in patients with hepatocellular carcinoma (HCC) with extrahepatic metastases.
Methodology: We retrospectively analyzed data from 57 patients diagnosed as having treatment-naïve stage IV HCC with extrahepatic metastases between 2007 and 2010. Comorbidity was assessed using two scoring systems, the Charlson comorbidity index (CCI) and the Kaplan-Feinstein index. Read More
Hepatogastroenterology 2015 Jun;62(140):1007-10
Background/aims: This work aims to observe the effects of mast cell (MC) chymase on activation, proliferation and transdifferentiation of hepatic stellate cells (HSCs) and to discuss the role of chymase in development of liver fibrosis.
Methodology: Rat HSCs were isolated by in situ perfusion using collagenase IV and proteinase E and density gradient centrifugation (Percoll method), followed by culture. After intervention by chymase with series of concentration (1, 10 and 100 ng/mL), MTT assay was performed to determine HSC proliferation. Read More
Hepatogastroenterology 2015 Jun;62(140):1002-6
Background/aims: To evaluate the efficacy and safety of doxorubicin-eluting beads combined with transcatheter arterial chemoembolization (DEB-TACE) compared with conventional TACE (cTACE).
Methodology: PubMed, EMBASE, MEDLINE and Cochrane Controlled Trials Register were searched for articles published to identify randomized controlled trials evaluating efficacy and side effects between DEB-TACE and cTACE. The RR (relative risk) with a 95% confidence interval (CI) was calculated by the Revman 5. Read More
Hepatogastroenterology 2015 Jun;62(140):997-1001
Background/aims: To explore the cause of functional changes of TNF-α in removing hepatitis B virus (HBV) through the structural changes of each site in TNF-α before and after mutation.
Methodology: Three typical mutant sites (TNF-α-308G/A, 857C/T and 863C/A of TNF-α) were chosen and methods like ab initio modeling was adopted for 3D modeling of TNF-α before and after mutation. The structural changes were also analyzed. Read More
Hepatogastroenterology 2015 Jun;62(140):992-6
Background/aims: This paper aims to investigate the effect of acute normovolemic hemodilution (ANH) used with controlled low central venous pressure (LCVP) technology on perioperative bleeding and coagulation in hepatocellular carcinoma operation patients.
Methodology: A total of 60 cases undergoing hepatic resection operation were randomly divided into the control group, LCVP group (Group II), and ANH + LCVP group (Group III). The changes of hemodynamic indexes at different time points in each group were observed and recorded, along with the volume of allogenous blood transfusion and the number of patients undergoing allogenous blood transfusion. Read More
Hepatogastroenterology 2015 Jun;62(140):987-91
Background/aims: Portal vein embolization (PVE) is an accepted procedure, which, by redirecting portal vein flow toward specific hepatic segments, is able to pre-operatively increase the volume of the future liver remnant (FLR). The consequent reduction of liver dysfunction risk enables to extend the number of pa tients eligible for major hepatic resection. This study aims at comparing liver regeneration dynamics and long-term volumetric recovery after major hepatic re section preceded by PVE versus major hepatic resec tion not preceded by PVE. Read More
Hepatogastroenterology 2015 Jun;62(140):982-6
Background/aims: Entecavir and tenofovir are generally accepted as first-line therapeutic options in chronic hepatitis B. Both of them are potent and have high genetic barrier to viral resistance. Aim of this study was to compare the two-year efficacy of entecavir and tenofovir in treatment-naive chronic hepatitis B patients. Read More
Hepatogastroenterology 2015 Jun;62(140):978-81
Background/aims: PET is a highly specific tool in liver cancer diagnosis. However, in small hepatic lesions, typical imaging characteristics are lacking. The aim of this study was to investigate the accuracy of PET-CT and ultrasound-guided biopsy for diagnosis of liver carcinomas. Read More
Hepatogastroenterology 2015 Jun;62(140):971-7
Background/aims: Mean survival in hepatocellular carcinoma remains low. Many efforts have been done during the last years through screening, diagnosis and treatment to improve the results. The aim of this work is to present the experience of our hospital multidisciplinary group during the first decade of this century. Read More
Hepatogastroenterology 2015 Jun;62(140):966-70
C-reactive protein (CRP) is an acute phase reactant synthesized by hepatocytes that is regulated by pro-inflammatory cytokines, particulary interleukin-6 (IL-6). Over the last decade, CRP has been reported to be associated with a poor prognosis in patients with various types of cancer. Although the mechanisms by which the systemic inflammatory response reflected by an elevated serum CRP level influences survival in patients with cancer have not been fully elucidated, several possibilities involving the activation of IL-6, thereby elevating the CRP level, in cancer patients have been proposed. Read More
Hepatogastroenterology 2015 Jun;62(140):962-5
Background/aims: To determine the utility of the quantitative apparent diffusion coefficient (ADC) values at various b values, in the differentiation of malignant hepatic masses on 3.0 Tesla (T) MRI.
Methodology: We evaluated 81 consecutive patients presenting with 529 malignant masses in the liver. Read More
Hepatogastroenterology 2015 Jun;62(140):955-61
Background/aims: Selection of patients with hepa- to-cellular carcinoma for liver transplantation is gen- erally performed according to the so-called Milan cri- teria. The aim of this study was to learn whether, after down-staging loco-regional therapies, patients origi- nally non-fulfilling the MC (Milan-OUT) meet these criteria (Milan-IN).
Methodology: Between January 2000 and December 2008, 172 patients with HCC re- ceived LT at our Department. Read More
Hepatogastroenterology 2015 Jun;62(140):951-4
Background/aims: Oxidized regenerated cellulose (ORC) has been registered as adjuncts to stimulate hemostasis in liver surgery. However, most previous studies were primarily designed to study the intra-operative hemostatic efficacy, and the effect on prophylactic application was never studied as a primary endpoint. This randomized prospective clinical trial was undertaken to evaluate whether ORC is safe and effective when used as a prophylactic agent covering the raw cut surface during the hepatectomy to reduce the volume and duration of drainage. Read More
Hepatogastroenterology 2015 Jun;62(140):947-50
Background/aims: Egypt has the highest prevalence of HCV worldwide (15%) with a high morbidity and mortality from chronic liver disease, cirrhosis, and hepatocellular carcinoma. The Aim of this study was to investigate the associations between IL-28B single nucleotide polymorphisms (SNP rs12979860) and treatment outcome among Egyptian patients infected with HCV genotype 4.
Methodology: HCV patients were genotyped as CC, CT, or TT at the polymorphic site, rs12979860 in unrelated case control of Egyptian population with HCV. Read More
Hepatogastroenterology 2015 Jun;62(140):942-6
Background/aims: Spontaneous rupture is a life-threatening complication of hepatocellular carcinoma (HCC). Although hemostasis can be achieved by transarterial embolization (TAE), the prognosis remains poor. The aims of this study were to evaluate the effectiveness of emergent TAE for ruptured HCC and to clarify the prognostic factors. Read More
Hepatogastroenterology 2015 Jun;62(140):937-41
Background/aims: Liver transplantation (LT) is an effective treatment modality for acute liver failure (ALF). However, no reports have examined a large number of patients who underwent adult living donor LT (LDLT) for ALF.
Methodology: Seventy-four adult patients who underwent LT including 72 LDLT in a single center over a period of 15 years were reviewed. Read More
Hepatogastroenterology 2015 Jun;62(140):933-6
Background/aims: Few studies have characterized the outcomes and clinical features of patients who undergo liver transplantation (LT) for hepatocellular carcinoma (HCC) due to non-viral causes.
Methodology: We retrospectively analyzed 188 patients with HCC who underwent LT between February 1999 and October 2010. The clinicopathological factors and overall survival rates as well as recurrence rates of 17 patients with non-hepatitis B virus (HBV) and non-hepatitis C virus (HCV) infection (NBNC group) and 171 patients with HBV or HCV infection (HBV/ HCV group) were compared. Read More
Hepatogastroenterology 2015 Jun;62(140):927-32
The chronic nature of Crohn's disease (CD) implicates necessity of multiple control assessments throughout patient's life. It is accepted that in patients with CD requiring disease monitoring, magnetic resonance enterography (MRE) and computed tomography enterography (CTE) are--apart from endoscopy--imaging studies of first choice. In practice, diagnostic imaging of patients with CD is troublesome, since MRE is an expensive and complicated study, and CTE exposes patients to high doses of ionizing radiation. Read More
Hepatogastroenterology 2015 Jun;62(140):924-6
Background/aims: In recent years, the side-to-side intestinal anastomosis has become a widely used technique. The purpose of this study was to evaluate the difference in the burst pressures and weak points using three different kinds of suture instruments.
Methodology: Fresh pig esophagus and small bowel were used for all experiments. Read More
Hepatogastroenterology 2015 Jun;62(140):919-23
Background/aims: Adjuvant treatment with imatinib mesylate (IM) improves survival of patients with a high risk of recurrence of gastrointestinal stromal tumors (GISTs). However, the optimal adjuvant treatment strategy remains unknown. Thus, this study aimed to identify patients who do not require adjuvant IM treatment using the Ki-67 labeling index (LI). Read More
Hepatogastroenterology 2015 Jun;62(140):913-8
Background/aims: To analyze our experience of segmental duodenectomy for tumors located at the third and fourth portion of the duodenum and attempt to explore the security and feasibility of this surgical procedure.
Methodology: A retrospective cohort study of five patients who underwent segmental duodenectomy in our hospital, medical records were analyzed in this study.
Results: The initial symptoms in five patients are not specific. Read More
Hepatogastroenterology 2015 Jun;62(140):907-12
Background/aims: To determine risk factors associated with mortality and increased drug costs in patients with nonvariceal upper gastrointestinal bleeding.
Methodology: We retrospectively analyzed data from patients hospitalized with nonvariceal upper gastrointestinal bleeding between January 2001-December 2011. Demographic and clinical characteristics and drug costs were documented. Read More
Hepatogastroenterology 2015 Jun;62(140):902-6
Background/aims: We aimed to investigate the efficacy of second line treatment with modified FOLFOX6 (mFOLFOX6) following cisplatin- plus 5-fluorourasil (CF) chemotherapy in patients with metastatic esophagus cancer (mEC).
Methodology: In our oncology clinic, between March 2011 and September 2014, we reviewed patients admitted with progressive mEC following first line CF chemotherapy and those with >60 kanofsky performance status performed second line mFOLFOX6 regimen.
Results: A total of 242 patients with mEC were evaluated. Read More
Hepatogastroenterology 2015 Jun;62(140):898-901
Background/aims: The purpose of this study is to assess the efficacy of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in predicting the pathological response of neoadjuvant chemoradiation (CRT) for clinically diagnosed T4 esophageal squamous cell carcinoma (SCC).
Methodology: We examined 32 patients with T4 thoracic esophageal SCC who received neoadjuvant CRT followed by surgery.
Results: Pathological complete response (pCR) was achieved in 7 patients (21. Read More
Hepatogastroenterology 2015 Jun;62(140):892-7
Background/aims: The aim of this study was to investigate the incidence and risk factors for anastomotic stricture after esophagectomy with gastric tube reconstruction.
Methodology: A total of 150 consecutive patients with esophageal cancer who underwent esophagectomy with gastric tube reconstruction were analyzed in this study. Anastomotic stricture was de fined as disturbance of the passage of a standard endo scope, with no evidence of locoregional cancer recurrence. Read More
Hepatogastroenterology 2015 Jun;62(140):887-91
Background/aims: The optimal treatment for locally advanced esophageal carcinoma has not yet been determined. We report results of neoadjuvant hyperthermo-chemoradiotherapy (HCRT) using weekly low-dose docetaxel followed by surgery in patients with advanced esophageal squamous cell carcinoma.
Methodology: Twenty-four patients were enrolled. Read More
Hepatogastroenterology 2015 Jun;62(140):880-6
Background/aims: To detect the cellular sensitivity to adriamycin (ADR) by assessing autophagy, apoptosis, and multidrug resistance gene 1 (mdr1) expression in LoVo/Adr cells.
Methodology: LoVo/Adr cells were designated accordingly into ADR group, Rapamycin (RAPA) group, ADR plus RAPA, and control group in main observations. Autophage, cell death and mdr1 were examined. Read More
Hepatogastroenterology 2015 Jun;62(140):876-9
Background/aims: Colorectal cancer is the fourth most common cancer diagnosed in the United States, and the third most common cause of death from cancer. Approximately 20% of the patients with colorectal cancer have distant metastasis during diagnosis. Primary tumor resection is controversial in unresectable metastatic colorectal cancer (CRC). Read More
Hepatogastroenterology 2015 Jun;62(140):873-5
Background/aims: Reduced port laparoscopic surgery has recently emerged as a method to improve the cosmetic results of conventional laparoscopic surgery. We reported our technique of reduced port laparoscopic colectomy using 3-port and short-time outcomes.
Methodology: Between 2005 and 2012, we performed 161 reduced port laparoscopic colectomies using the 3-port technique. Read More
Hepatogastroenterology 2015 Jun;62(140):868-72
Background/aims: The efficacy and safety of neoadjuvant chemotherapy in patients with highly advanced rectal cancer for whom radical surgery was considered difficult were evaluated.
Methodology: From June 2007 to February 2011, 10 advanced lower rectal cancer patients with factors contraindicative of curative surgery with total mesenteric excision were eligible for this study. Neoadjuvant chemotherapy consisting of modified OPTIMOX1 (mFOLFOX6 and sLV5FU2 alternating administration) plus bevacizumab was administered. Read More
Hepatogastroenterology 2015 Jun;62(140):863-7
Background/aims: Transanal minimally invasive surgery (TAMIS) has received attention as an alternative to transanal endoscopic microsurgery for rectal lesions. We review the effectiveness and safety of TAMIS for the treatment of rectal lesions.
Methodology: The MEDLINE, Web of Science, and Cochrane Library databases were searched using predefined inclusion criteria. Read More
Hepatogastroenterology 2015 Jun;62(140):859-62
Background/aims: Complete resection of tumors is possible after heavy chemotherapy in a few patients with unresectable colorectal cancer (UCRC). This study evaluated the ability of new prognostic score to identify such patients.
Methodology: Four peripheral blood markers were evaluated in 50 patients diagnosed with UCRC at the time of patients' first visit to the hospital: C-reactive protein (CRP), albumin (ALB), neutrophil/lymphocyte ratio (NLR), and carcinoembryonic antigen (CEA). Read More
Hepatogastroenterology 2015 Jun;62(140):853-8
Background/aims: Despite recent advances in medical therapy, the role of surgery for severe ulcerative colitis remains important and determining the timing and indications for colectomy are difficult for both gastroenterologists and surgeons. We compared the clinical characteristics and postoperative complications of emergency surgeries for ulcerative colitis to those of elective surgeries.
Methodology: We retrospectively examined 77 patients with ulcerative colitis who underwent colectomy without cancer or dysplasia in our institute in 1989-2012. Read More
Hepatogastroenterology 2015 Jun;62(140):846-52
Background/aims: Laparoscopic approaches are increasingly used in selected patients with either colorectal or liver disease. The aim of this study was to evaluate the safety and feasibility of laparoscopy-assisted combined colorectal and liver resection for primary colorectal cancer (CRC) with synchronous liver metastases.
Methodology: Thirteen patients with CRC with synchronous liver metastases who underwent simultaneous laparoscopic colectomy and hepatic resection from January 2009 through July 2013 were evaluated. Read More
Hepatogastroenterology 2015 Jun;62(140):843-5
Background/aims: The Endoscopic Operation Robot (EOR) ver. 1 was developed in order to provide robotized operational support for flexible endoscopes, which can be complicated to manipulate. However, total colonoscopy examinations with a colonoscopy training model by proficient operation of the joystick using the EOR ver. Read More
Hepatogastroenterology 2015 Jun;62(140):838-42
Background/aims: This study aimed to investigate the clinicopathological characteristics of synchronous and metachronous colorectal cancers (CRCs).
Methodology: From January 1, 2001 to December 31, 2010, 5898 patients who underwent surgical resection for CRCs were enrolled. Synchronous CRC was defined as presence of more than one primary CRC within 6 months of resection of the primary tumor; while CRC that occurred at least 6 months later was regarded as metachronous CRC. Read More
Hepatogastroenterology 2015 Jun;62(140):829-37
Background/aims: TNF-α has an important role in the pathogenesis of ulcerative colitis (UC). It seems that anti-TNF-α therapy is beneficial in the treatment of UC. The aim was to assess the effectiveness of Infliximab and Adalimamab with UC compared with con- ventional therapy. Read More
Hepatogastroenterology 2015 Jun;62(140):825-8
Background/aims: Assessment of oxaliplatin-associated hepatotoxicity in patients receiving oxaliplatin, fluorouracil and leucovorin chemotherapy (FOLFOX) for colorectal cancer remains controversial. The aims of this study were to clarify which variables are indicators of such hepatotoxicity.
Methodology: Twenty-seven patients who were to receive FOLFOX for colorectal cancer were included in this study. Read More
Hepatogastroenterology 2015 Jun;62(140):821-4
Background/aims: Patients with ulcerative colitis suffer from long term impairment of quality of life, especially when subjected to repeated hospitalization. We aimed to identify factors that may predict future hospitalization.
Methodology: We followed 139 consecutive patients with ulcerative colitis for average of 11. Read More
Hepatogastroenterology 2015 Jun;62(140):817-20
Background/aims: Ostomy creation is a fundamental technique. However, little information is available concerning the procedure and the associated complications. We reviewed the relationship between the ostomy procedure and complications. Read More
Hepatogastroenterology 2015 Jun;62(140):811-6
Background/aims: Minimally invasive laparoscopy provides faster recovery, less pain, fewer complications, and better cosmesis than laparotomy. We aimed to evaluate outcomes of postoperative local anesthesia infiltration at the single-incision laparoscopic surgery (SILS) wound.
Methodology: This prospective, non-randomized controlled study evaluated outcomes of 58 colorectal cancer cases receiving SILS from May 2010 to December 2010. Read More
Hepatogastroenterology 2015 Jun;62(140):807-10
Background/aims: We analyzed the effects of the Kampo medicine "Dai-kenchu-to" (DKT) on clinical aspects in colorectal surgery.
Methodology: Total 122 patients who underwent colorectal cancer surgery were divided into a DKT group (n = 53) and a non-DKT group (n = 69). The differences of postoperative course and anti-inflammatory responses between those two groups were analyzed. Read More
Hepatogastroenterology 2015 Jun;62(140):802-6
Background/aims: Circulating hepatocellular carcinoma cells (CHCCs) may be detected by reverse transcription-polymerase chain reaction (RT-PCR). We investigated the relationship between CHCCs and hepatoma patients' survival period after different managements.
Methodology: Peripheral blood (5 ml) samples were obtained from 93 patients with hepatocellular carcinoma (HCC), and from 33 control subjects (9 with liver cirrhosis after hepatitis B, 14 with chronic hepatitis B, 10 with healthy people) between January 1st, 2009 and December 31, 2012. Read More
Hepatogastroenterology 2015 Jun;62(140):797-801
Background/aims: This study was designed to investigate the effect of bevacizumab plus chemotherapy such as pemetrexed and carboplatin followed by maintenance bevacizumab in patients with advanced, nonsquamous nonsmall cell lung cancer.
Methodology: Previously untreated patients with advanced, non-squamous nonsmall cell lung cancer received bevacizumab 15 mg/kg, pemetrexed 500 mg/m2 and carboplatin atan area under the concentration-time curve of 6 intravenously on day 1 every 21 days. Responding or stable patients who completed 6 cycles then received bevacizumab maintenance every 21 days until disease progression. Read More