113,613 results match your criteria Hepatitis Viral


A pan-genotypic Hepatitis C Virus NS5A amplification method for reliable genotyping and resistance testing.

J Clin Virol 2019 Jan 30;113:8-13. Epub 2019 Jan 30.

Institute of Virology, Heinrich-Heine-University, University Hospital, Düsseldorf, Germany.

Background: Chronic infection with the Hepatitis C Virus (HCV) is associated with the risk of progressive liver disease. Although, HCV treatment options and viral cure rates have tremendously increased over the last decade, all currently licensed combination therapies contain inhibitors of the replication complex NS5A. Resistance-associated substitutions (RAS) in NS5A can limit the efficacy of therapy; however, resistance testing is routinely not recommended for all patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193002
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http://dx.doi.org/10.1016/j.jcv.2019.01.012DOI Listing
January 2019
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New treatment option for delta virus: is a cure in sight?

Authors:
Cihan Yurdaydin

J Viral Hepat 2019 Feb 16. Epub 2019 Feb 16.

Department of Gastroenterology, Ankara University Medical School, Cebeci Tıp Fakültesi Hastanesi, Dikimevi, 06100, Ankara, Turkey.

Current treatment of chronic hepatitis D viral infection with interferons is poorly tolerated and effective only in a minority of patients. Despite Delta virus causing the most severe form of chronic viral hepatitis no other treatments are available. After many years of inactivity there is now hope for new treatment approaches for Delta virus and some are likely to enter clinical practice in the near future. Read More

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http://dx.doi.org/10.1111/jvh.13081DOI Listing
February 2019

Economic evaluation of a publicly funded hepatitis A travel vaccination program in Ontario, Canada.

Vaccine 2019 Feb 12. Epub 2019 Feb 12.

School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 1P8, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada; Public Health Ontario, 480 University Avenue, Toronto, Ontario M5G 1V2, Canada; Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Background: Hepatitis A virus (HAV) causes acute liver infection and is spread through the fecal-oral route. Travel to countries in HAV-endemic regions (e.g. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.070DOI Listing
February 2019

Vaccination strategies for control of community outbreaks of hepatitis A: A comparison of two outbreaks in England.

Vaccine 2019 Feb 12. Epub 2019 Feb 12.

Health Protection Team, Public Health England Yorkshire and the Humber, Leeds, UK.

In August 2015 two community outbreaks of hepatitis A virus (HAV) occurred in sub-urban communities in Northern England. Each was managed by an independent outbreak control team. In outbreak one, mass vaccination was deployed targeting a residential area and two schools, while in outbreak two, vaccination was reserved for household-type contacts of cases. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.026DOI Listing
February 2019

Hepatitis C Clinical Dashboards: Improving Liver Specialty Care Access and Quality.

Fed Pract 2015 Feb;32(Suppl 2):32S-36S

is an academic detailing data manager, Department of Pharmacy, VHA Pharmacy Benefits Management, Los Angeles, California. is a staff physician, Department of Medicine, Puget Sound VAMC and University of Washington School of Medicine, Seattle, Washington. is the VISN 22 pharmacoeconomist and pharmacy data analyst, Desert Pacific VISN in Long Beach, California. is the Viral Hepatitis National Public Health Clinical Lead, San Francisco VAMC, University of California San Francisco and an assistant professor at the University of California, San Francisco School of Medicine.

Clinical dashboards can improve the health management of the HCV population within the VHA by empowering health care practitioners to deliver wide and effective HCV care. Read More

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February 2015

Accelerated Hepatitis A and B Immunization in a Substance Abuse Treatment Program.

Fed Pract 2015 Aug;32(8):38-43

is a clinical psychologist, is an attending psychiatrist, is a clinical psychologist, is a retired licensed practical nurse, is a retired registered nurse, is a retired registered nurse, and is an attending psychiatrist, all at the James A. Haley Veterans' Hospital in Tampa, Florida. is an advanced registered nurse practitioner at American Lake Division of the VA Puget Sound Healthcare System in Lakewood, Washington. Dr. Winn is an assistant professor, Dr. Francis is an associate professor, Dr. Shealy is an assistant professor, and Dr. Gonzales-Nolas is an assistant professor, all at the University of South Florida in Tampa.

An accelerated dosing program for hepatitis A and B vaccination among veterans receiving treatment for addictive disorders was successfully implemented, although many veterans with hepatitis C did not complete the immunization series. Read More

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Evaluation of brain volume alterations in HCV-infected patients after interferon-free therapy: A pilot study.

J Neurol Sci 2019 Feb 7;399:36-43. Epub 2019 Feb 7.

Department of General Radiology, Interventional Radiology and Neuroradiology, Radiology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

The study was performed to evaluate cerebral volume changes in HCV-infected subjects before and after interferon-free therapy with direct-acting antiviral agents (DAA). We aimed also to estimate the impact of successful DAA therapy on the neuropsychological state of patients. Eleven HCV genotype 1 (GT1) patients treated with ombitasvir/paritaprevir (boosted with ritonavir) and dasabuvir, with or without ribavirin underwent brain magnetic resonance (MR) before and 24 weeks after completion of therapy. Read More

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http://dx.doi.org/10.1016/j.jns.2019.02.002DOI Listing
February 2019

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors.

J Hepatol 2019 Feb 12. Epub 2019 Feb 12.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Str. 7, 30625 Hannover, Germany; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 30625 Hannover, Germany. Electronic address:

Background & Aims: Hepatitis C virus infection causes chronic liver disease. Antivirals have been developed and cure infection. However, resistance can emerge and salvage therapies with alternative modes of action could be useful. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.01.033DOI Listing
February 2019

Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?

Clin J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Giant cell hepatitis in adults is considered a rapidly progressive and life-threatening disease, but there are few descriptions of a prolonged disease course. A 36-year-old Japanese man was referred to our hospital for further evaluation of abnormal liver function test results. Although asymptomatic, he had undergone follow-up for 9 years with these abnormalities. Read More

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http://dx.doi.org/10.1007/s12328-019-00950-6DOI Listing
February 2019

Immunomodulatory Effects of Combination Therapy with Bushen Formula plus Entecavir for Chronic Hepatitis B Patients.

J Immunol Res 2019 13;2019:8983903. Epub 2019 Jan 13.

Laboratory of Cellular Immunity, Institute of Clinical Immunology, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, China.

Aim: To compare the clinical efficacy of the combination therapy with Bushen formula (BSF) plus entecavir (ETV) in naïve chronic hepatitis B (CHB) patients and that in CHB patients with partial virological response to ETV and explore the relevant immunoregulatory mechanism.

Materials And Methods: Two hundred and twenty CHB patients were enrolled in the historical prospective cohort study. Patients were categorized into a treatment group (T-Group: combination therapy with BSF plus ETV) and a control group (C-Group: ETV). Read More

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http://dx.doi.org/10.1155/2019/8983903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350602PMC
January 2019

Genetic diversity of hepatitis B co-infection with hepatitis C, D and E viruses among Malaysian chronic hepatitis B patients.

Afr Health Sci 2018 Dec;18(4):1117-1133

Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University Putra Malaysia.

Background: Hepatitis B virus co-infection with other strains of viral hepatitis is associated with increased risk of liver cirrhosis and hepatic decompensation.

Objectives: This is a prevalence study that assessed the genetic diversity of chronic hepatitis B patients and coinfection.

Methods: Chronic hepatitis B patients enrolled in this study were tested for antibodies of other hepatitis viruses using ELISA kits. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354894PMC
December 2018

Hepatitis A Virus Prevention and Vaccination Within and Outside the Veterans Health Administration in Light of Recent Outbreaks.

Fed Pract 2018 Mar;35(Suppl 2):S32-S37

is a Fellow in the Division of Gastroenterology and Hepatology at University of North Carolina School of Medicine in Chapel Hill, North Carolina. is a Data Analyst for the HHRC Data and Analytics Group and Data Analyst for Health Services Research and Development at VA Puget Sound Healthcare System. is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration (VHA), Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Infectious Diseases Section at VA Portland Healthcare System in Oregon and an Assistant Professor in the Division of Infectious Diseases at Oregon Health and Sciences University in Portland. Dr. Maier is the National Public Health Infectious Disease Officer. is the Director of the HHRC National Hepatitis Resource Center; Chief, Gastroenterology at VA Long Beach Healthcare System in California; and Professor in the Division of Gastroenterology at University of California, Irvine. is National Program Manager for Prevention Policy at VHA National Center for Health Promotion and Disease Prevention in Durham, North Carolina.

Although widespread hepatitis A vaccination has dramatically decreased infection rates, a large proportion of VA patients in traditionally high-risk groups remains susceptible to infection. Read More

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The Changing Face of Hepatocellular Carcinoma: Forecasting Prevalence of Nonalcoholic Steatohepatitis and Hepatitis C Cirrhosis.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):50-55. Epub 2018 Feb 16.

Rush University Medical Center, 1653 W Congress Parkway, Chicago, IL 60612, USA.

Background/objectives: The purpose of this research is to analyze the past and forecast the future prevalence of Hepatitis C Virus (HCV) and Nonalcoholic Steatohepatitis (NASH) and their respective contribution to Hepatocellular Carcinoma (HCC) incidence in the setting of novel anti-viral agents and rising obesity rates in the United States.

Methods: Existing data of HCV and NASH prevalence in the United States utilizing the National Health and Nutrition Examination Survey (NHANES) and Organ Procurement and Transplantation Network (OPTN) was collected and analyzed to project future prevalence trends.

Results: Prevalence of NASH and HCV are expected to increase and decline respectively over the next two decades with alcoholic cirrhosis expected to stay relatively unchanged. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363953PMC
February 2018

Potential Implications of Detecting HBsAg in Asymptomatic People in an Endemic Community Through Medical Camps.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):43-49. Epub 2018 Feb 16.

HOPE (Health Oriented Programs and Education) Initiative, 422, Aradhana, Eldeco 2, Rae Bareli Road, Lucknow 226025, UP, India.

Background: In a developing country like India with intermediate level of prevalence of hepatitis B, most of the patients remain undiagnosed as they are asymptomatic. The purpose of the study was to diagnose asymptomatic HBsAg positive patients from the general population and evaluate further the potential clinical implications of IDAHS.

Methods: Asymptomatic subjects with unknown HBV status were screened free of cost for hepatitis-B surface antigen. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363955PMC
February 2018

Evaluation of Plasma Urokinase-Type Plasminogen Activator Receptor (UPAR) in Patients With Chronic Hepatitis B, C and Non-Alcoholic Fatty Liver Disease (NAFLD) as Serological Fibrosis Marker.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):29-33. Epub 2018 Feb 16.

Department of Gastroenterology, Faculty of Medicine, Gazi University, Ankara, Turkey.

Background/aims: Progressive hepatic fibrosis is the main predictor of outcome and prognosis in chronic liver diseases. The importance of the coagulation cascade has been defined in liver fibrosis; however, the role of the fibrinolytic pathway has not been clear yet. We aimed to evaluate the association between the plasma levels of soluble urokinase Plasminogen Activator Receptor (uPAR) and the severity of liver fibrosis in chronic hepatitis B, C and Non-Alcoholic Fatty Liver Disease (NAFLD). Read More

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http://dx.doi.org/10.1016/j.jceh.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363952PMC
February 2018

Network controllability analysis of intracellular signalling reveals viruses are actively controlling molecular systems.

Sci Rep 2019 Feb 14;9(1):2066. Epub 2019 Feb 14.

Evolution and Genomic Sciences, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK.

In recent years control theory has been applied to biological systems with the aim of identifying the minimum set of molecular interactions that can drive the network to a required state. However, in an intra-cellular network it is unclear how control can be achieved in practice. To address this limitation we use viral infection, specifically human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV), as a paradigm to model control of an infected cell. Read More

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http://www.nature.com/articles/s41598-018-38224-9
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http://dx.doi.org/10.1038/s41598-018-38224-9DOI Listing
February 2019
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Clinical outcomes in patients with chronic hepatitis C after direct-acting antiviral treatment: a prospective cohort study.

Lancet 2019 Feb 11. Epub 2019 Feb 11.

AP-HP, Hôpital Cochin, Unité d'Hépatologie, Paris, France; Université Paris Descartes, INSERM U1223 and USM-20, Institut Pasteur, Paris, France.

Background: Although direct-acting antivirals have been used extensively to treat patients with chronic hepatitis C virus (HCV) infection, their clinical effectiveness has not been well reported. We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort.

Methods: We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France. Read More

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http://dx.doi.org/10.1016/S0140-6736(18)32111-1DOI Listing
February 2019

Evidence of sustained reductions in the relative risk of acute hepatitis B and C virus infections, and the increasing burden of hepatitis a virus infection in Egypt: comparison of sentinel acute viral hepatitis surveillance results, 2001-17.

BMC Infect Dis 2019 Feb 14;19(1):159. Epub 2019 Feb 14.

Ministry of Health and Population, Cairo, Egypt.

Background: Egypt ranks fifth for the burden of viral hepatitis worldwide. As part of Egypt's renewed national strategy for the elimination of viral hepatitis, surveillance for acute viral hepatitis (AVH) was re-established during 2014-2017 to describe the current epidemiology and associated risk factors, and changes from surveillance conducted during 2001-2004.

Methods: Patients with suspected AVH were enrolled, completed a questionnaire, and provided blood for testing for hepatitis viruses A (HAV), B (HBV), C (HCV), D, and E (HEV) infections by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1186/s12879-019-3806-9DOI Listing
February 2019

Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Persons Experiencing Homelessness.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):153-156. Epub 2019 Feb 15.

Hepatitis A (HepA) vaccination is recommended routinely for children at age 12-23 months, for persons who are at increased risk for hepatitis A virus (HAV) infection, and for any person wishing to obtain immunity. Persons at increased risk for HAV infection include international travelers to areas with high or intermediate hepatitis A endemicity, men who have sex with men, users of injection and noninjection drugs, persons with chronic liver disease, person with clotting factor disorders, persons who work with HAV-infected primates or with HAV in a research laboratory setting, and persons who anticipate close contact with an international adoptee from a country of high or interme-diate endemicity (1-3). Persons experiencing homelessness are also at higher risk for HAV infection and severe infection-associated outcomes. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a6.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6806a6DOI Listing
February 2019
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Increased Methamphetamine, Injection Drug, and Heroin Use Among Women and Heterosexual Men with Primary and Secondary Syphilis - United States, 2013-2017.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):144-148. Epub 2019 Feb 15.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC.

During 2013-2017, the national annual rate of reported primary and secondary (P&S) syphilis cases in the United States increased 72.7%, from 5.5 to 9. Read More

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http://dx.doi.org/10.15585/mmwr.mm6806a4DOI Listing
February 2019

Design of N-Benzoxaborole Benzofuran GSK8175 - Optimization of Human PK Inspired by Metabolites of a Failed Clinical HCV Inhibitor.

J Med Chem 2019 Feb 14. Epub 2019 Feb 14.

We previously described the discovery of GSK5852 (1), a non-nucleoside polymerase (NS5B) inhibitor of hepatitis C virus (HCV), in which a N-benzyl boronic acid was essential for potent antiviral activity. Unfortunately, facile benzylic oxidation resulted in a short plasma half-life (5 h) in human volunteers, and a backup program was initiated to remove metabolic liabilities associated with 1. Herein we describe second generation NS5B inhibitors including GSK8175 (49), a sulfonamide-N-benzoxaborole analog with low in vivo clearance across preclinical species and broad-spectrum activity against HCV replicons. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01719DOI Listing
February 2019

Experience with antiviral agents for treatment of hepatitis C virus infection in hemodialysis patients on the kidney wait list.

Hemodial Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Transplantation and General Surgery, Baskent University Faculty of Medicine, Adana, Turkey.

Introduction: Hepatitis C virus (HCV) infection is associated with increased mortality and morbidity in kidney transplant patients. The ability to establish a sustained viral response before renal transplant is important for these patients. Direct-acting antiviral agents can increase the sustained viral response in most patients with HCV infection. Read More

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http://dx.doi.org/10.1111/hdi.12719DOI Listing
February 2019

Review article: iron disturbances in chronic liver diseases other than haemochromatosis - pathogenic, prognostic, and therapeutic implications.

Authors:
Albert J Czaja

Aliment Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Background: Disturbances in iron regulation have been described in diverse chronic liver diseases other than hereditary haemochromatosis, and iron toxicity may worsen liver injury and outcome.

Aims: To describe manifestations and consequences of iron dysregulation in chronic liver diseases apart from hereditary haemochromatosis and to encourage investigations that clarify pathogenic mechanisms, define risk thresholds for iron toxicity, and direct management METHODS: English abstracts were identified in PubMed by multiple search terms. Full length articles were selected for review, and secondary and tertiary bibliographies were developed. Read More

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http://dx.doi.org/10.1111/apt.15173DOI Listing
February 2019

Frequency and Implications of Myeloid Derived Suppressor Cells and Lymphocyte Subsets in Egyptian Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma.

J Med Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Faculty of Medicine, Assiut University, Egypt.

Background And Aim: Myeloid-derived suppressor cells (MDSCs) play a pivotal role in tumor immunity and induction of immune tolerance to a variety of antitumor effectors, including T-lymphocytes. Herein, we tried to evaluate the frequency and clinical significance of MDSCs and different lymphocyte subsets in HCV- related hepatocellular carcinoma (HCC).

Methods: Four groups were enrolled; chronic HCV (CHC, n=40), HCV related liver cirrhosis (HCV-LC, n= 40), HCV related HCC (HCV-HCC, n=75) and healthy control group (n=20). Read More

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http://dx.doi.org/10.1002/jmv.25428DOI Listing
February 2019

Association of Hepatitis C and B Virus Infection with CKD and Impact of Hepatitis C Treatment on CKD.

Sci Rep 2019 Feb 13;9(1):1910. Epub 2019 Feb 13.

Department of Hepatology, The First Hospital of Jilin University, Jilin University, Changchun, 130021, China.

Hepatitis C virus (HCV) infection greatly increases the risk of nephropathy. In this observational study, we aimed to explore the relationship between viral hepatitis infection and chronic kidney disease (CKD), identify risk factors, and determine the effect of antiviral treatment on CKD in Chinese patients with chronic HCV infection. A total of 2,435 study subjects were enrolled and divided into four groups: the HCV infection, HBV infection, HBV and HCV co-infection, and uninfected control groups. Read More

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http://dx.doi.org/10.1038/s41598-018-36437-6DOI Listing
February 2019

Maternal hepatitis B surface antigen carrier status increased the incidence of gestational diabetes mellitus.

BMC Infect Dis 2019 Feb 13;19(1):147. Epub 2019 Feb 13.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13th Hangkong Road, Wuhan, 430030, Hubei, China.

Background: The relationship between chronic hepatitis B virus (HBV) infection with gestational diabetes mellitus (GDM) remains unclear. This study aimed to identify the association between maternal HBsAg-positive status and GDM.

Methods: A retrospective cohort study was performed on the pregnant women who delivered from June 2012 to May 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China. Read More

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http://dx.doi.org/10.1186/s12879-019-3749-1DOI Listing
February 2019

Advanced Hepatitis C Virus Replication PDE Models within a Realistic Intracellular Geometric Environment.

Int J Environ Res Public Health 2019 Feb 12;16(3). Epub 2019 Feb 12.

Goethe Center for Scientific Computing (G-CSC), Goethe Universität Frankfurt, Kettenhofweg 139, 60325 Frankfurt am Main, Germany.

The hepatitis C virus (HCV) RNA replication cycle is a dynamic intracellular process occurring in three-dimensional space (3D), which is difficult both to capture experimentally and to visualize conceptually. HCV-generated replication factories are housed within virus-induced intracellular structures termed membranous webs (MW), which are derived from the Endoplasmatic Reticulum (ER). Recently, we published 3D spatiotemporal resolved diffusion⁻reaction models of the HCV RNA replication cycle by means of surface partial differential equation (sPDE) descriptions. Read More

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http://dx.doi.org/10.3390/ijerph16030513DOI Listing
February 2019

Spontaneous Cirrhosis Regression in an IFN-beta-induced AIH-like Syndrome Following Drug Withdrawal: Art of Facts or Artifacts?

Eur J Case Rep Intern Med 2016 20;3(4):000396. Epub 2016 Apr 20.

Department of Medicine and Research Laboratory of Internal Medicine, School of Medicine, University of Thessaly, Larissa, Greece.

Autoimmune hepatitis (AIH) is a disease of unknown aetiology with drug-induced AIH being the most complex and not fully understood type. We present the case of a 57-year-old female patient with acute icteric hepatitis after interferon-beta-1b (IFNβ-1b) administration for multiple sclerosis (MS). Based on liver autoimmune serology, histology and appropriate exclusion of other liver diseases, a diagnosis of AIH-related cirrhosis was established. Read More

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http://dx.doi.org/10.12890/2016_000396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346866PMC

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.

Cell Rep 2019 Feb;26(7):1800-1814.e5

Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination of the HCV nonstructural (NS) 2 protein mediates HRS (ESCRT-0 component) binding and envelopment. Nevertheless, the ubiquitin signaling that governs NS2 ubiquitination remained unknown. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.075DOI Listing
February 2019

Therapeutic effect of double plasma molecular adsorption system and sequential half-dose plasma exchange in patients with HBV-related acute-on-chronic liver failure.

J Clin Apher 2019 Feb 13. Epub 2019 Feb 13.

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China.

Objective: The artificial liver support system (ALSS) is used frequently as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). This study aims to compare the therapeutic efficacy of double plasma molecular adsorption system (DPMAS) with sequential half-dose plasma exchange (PE) (DPMAS+PE) and full-dose PE in patients with HBV-ACLF.

Methods: A total of 131 hospitalized patients who were diagnosed with HBV-ACLF and underwent DPMAS+PE or PE were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/jca.21690DOI Listing
February 2019

Community Levels of PrEP Use Among Men Who Have Sex with Men by Race/Ethnicity, San Francisco, 2017.

AIDS Behav 2019 Feb 13. Epub 2019 Feb 13.

San Francisco Department of Public Health, San Francisco, CA, USA.

Efforts in San Francisco are maximizing the use of pre-exposure prophylaxis (PrEP) among men who have sex with men (MSM) where high levels of use are needed to maximize reducing new HIV infections. National HIV Behavioral Surveillance surveys MSM in San Francisco. Demographics, health care and risk behaviors are assessed. Read More

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http://dx.doi.org/10.1007/s10461-019-02428-5DOI Listing
February 2019

Patients with HCV genotype-1 who have failed a direct-acting antiviral regimen: virological characteristics and efficacy of retreatment.

Antivir Ther 2019 Feb 13. Epub 2019 Feb 13.

Laboratory for the Identification of Prognostic Factors of Response to the Treatment Against Infectious Diseases, University of Campania L. Vanvitelli, Naples, Italy.

Background: This real-world clinical-setting study characterized the virological patterns in genotype-1 patients failing IFN-free regimens and evaluated the efficacy of re-treatment.

Methods: Seventy-three consecutive patients failing IFN-free regimens were enrolled (17 genotype 1a and 56 1b). At failure Sanger sequencing of NS3, NS5A and NS5B regions was performed by home-made protocols. Read More

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http://dx.doi.org/10.3851/IMP3296DOI Listing
February 2019

New Face of Hepatitis C.

Dig Dis Sci 2019 Feb 13. Epub 2019 Feb 13.

Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Chronic hepatitis C viral (HCV) infection continues to carry a high burden of disease despite recent and emerging advancements in treatment. The persistently high prevalence of HCV is attributed to the rising opioid epidemic, with a history of injection drug use as the primary risk factor for infection. As a result, the epidemiology of HCV-infected individuals is changing. Read More

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http://link.springer.com/10.1007/s10620-019-05511-y
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http://dx.doi.org/10.1007/s10620-019-05511-yDOI Listing
February 2019
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HSV Hepatitis in Pregnancy: A Review of the Literature.

Obstet Gynecol Surv 2019 Feb;74(2):93-98

Staff Physician, University of Arkansas for Medical Sciences, Little Rock, AR.

Importance: Herpes simplex virus (HSV) hepatitis is a rare condition with a high mortality rate. Immunocompromised individuals, including pregnant women, are the most susceptible. When primary infection occurs during pregnancy, risk for disseminated HSV is greatly increased. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000642DOI Listing
February 2019

Primary Hepatic Diffuse Large B-cell Lymphoma Mimicking Acute Fulminant Hepatitis: A Case Report and Review of the Literature.

Eur J Case Rep Intern Med 2018 26;5(6):000878. Epub 2018 Jun 26.

Department of Internal Medicine, Middle East Institute of Health, Faculty of Medical Science, Lebanese University, Hadath, Lebanon.

Primary hepatic lymphoma (PHL) is a rare variant of non-Hodgkin's lymphoma. Diffuse hepatic involvement is uncommon and therefore presentation as progressive hepatitis or acute fulminant hepatic failure is rare. Acute onset of signs and symptoms can mimic a variety of infectious and inflammatory disorders, thus delaying the diagnosis. Read More

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http://dx.doi.org/10.12890/2018_000878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346882PMC

Fatal Septic Shock Associated with Herpes Simplex Virus Hepatitis: A Case Report.

Eur J Case Rep Intern Med 2018 27;5(12):000982. Epub 2018 Dec 27.

Intensive Care Unit, Iris South Hospitals, Brussels, Belgium.

Herpes simplex viruses are endemic worldwide, with an estimated seroprevalence of approximately 70% in developed countries. However, it is less well known that they are one of the viral causes of fulminant hepatitis (<2%) and constitute <1% of all causes of acute liver failure. We describe the case of an 89-year-old man who developed sepsis caused by a urinary tract infection due to drug-sensitive . Read More

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http://dx.doi.org/10.12890/2018_000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346974PMC
December 2018

Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9.

Sci Rep 2019 Feb 12;9(1):1847. Epub 2019 Feb 12.

Central Research Institute of Epidemiology, Viral Hepatitis, Moscow, 111123, Russian Federation.

Chronic hepatitis B is a severe liver disease caused by hepatitis B virus (HBV) infection. Covalently closed circular DNA (cccDNA), a super-spiralized, double-stranded form of the HBV genome, is the major determinant of viral persistence. CRISPR/Cas9 nucleases have been recently shown to introduce double-stranded DNA breaks into HBV cccDNA. Read More

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http://dx.doi.org/10.1038/s41598-019-38526-6DOI Listing
February 2019

Ribonucleotide reductase M2 promotes RNA replication of hepatitis C virus by protecting NS5B protein from hPLIC1-dependent proteasomal degradation.

J Biol Chem 2019 Feb 12. Epub 2019 Feb 12.

Joint Faculty of Veterinary Medicine, Kagoshima University, Japan.

Hepatitis C virus (HCV) establishes a chronic infection that can lead to cirrhosis and hepatocellular carcinoma. The HCV life cycle is closely associated with host factors that promote or restrict viral replication, the characterization of which could help to identify potential therapeutic targets. To this end, here we performed a genome-wide microarray analysis andidentified ribonucleotide reductase M2 (RRM2) as a cellular factor essential for HCV replication. Read More

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http://dx.doi.org/10.1074/jbc.RA118.004397DOI Listing
February 2019

Timeliness and completeness of routine childhood vaccinations in young children residing in a district with recurrent vaccine-preventable disease outbreaks, Jerusalem, Israel.

Euro Surveill 2019 Feb;24(6)

Chief Scientist, Ministry of Health, Jerusalem, Israel.

BackgroundChildhood vaccination schedules recommend vaccine doses at predefined ages.AimWe evaluated vaccination completeness and timeliness in Jerusalem, a district with recurrent vaccine-preventable disease outbreaks.MethodsVaccination coverage was monitored by the up-to-date method (vaccination completeness at age 2 years). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1800004DOI Listing
February 2019

Unmet need in chronic hepatitis B management.

Clin Mol Hepatol 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China.

Despite all these exciting developments, there remain some unmet needs in the management for patients with chronic hepatitis B (CHB). As majority of CHB patients are going to use oral nucleos(t)ide analogues (NAs) for decades, Safety profile of NAs is of no doubt an important issue. The newest nucleotide analogue tenofovir alafenamide is potent in terms of viral suppression, together with favourable renal and bone safety profile. Read More

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http://dx.doi.org/10.3350/cmh.2018.0106DOI Listing
February 2019

Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses.

J Med Microbiol 2019 Feb 12. Epub 2019 Feb 12.

3 NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK.

The liver-expressed pattern recognition receptors mannose-binding lectin (MBL), ficolin-2 and ficolin-3 contribute to the innate immune response by activating complement. Binding of soluble ficolin-2 to viral pathogens can directly neutralize virus entry. We observed that the human hepatoma cell line HuH7. Read More

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http://dx.doi.org/10.1099/jmm.0.000935DOI Listing
February 2019
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Mineral Waste Containing High Levels of Iron from an Environmental Disaster (Bento Rodrigues, Mariana, Brazil) is Associated with Higher Titers of Enteric Viruses.

Food Environ Virol 2019 Feb 12. Epub 2019 Feb 12.

Microbiology Section, Department of Biotechnology and Food Science, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain.

Although the effects of heavy metals on the behavior, including infectivity, of bacteria have been studied, little information is available about their effects on enteric viruses. We report an investigation of effects on the biosynthesis of human adenoviruses (HAdV) and hepatitis A (HAV) of waters contaminated with mineral waste following an environmental disaster in Mariana City, Minas Gerais State, Brazil. The study area was affected on November 5, 2015, by 60 million m of mud (containing very high concentrations of iron salts) from a mining reservoir (Fundão), reaching the Gualaxo do Norte River (sites evaluated in this study), the "Rio Doce" River and finally the Atlantic Ocean. Read More

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http://link.springer.com/10.1007/s12560-019-09373-5
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http://dx.doi.org/10.1007/s12560-019-09373-5DOI Listing
February 2019
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Mathematical and Computational Techniques for Drug Discovery: Promises and Developments.

Curr Top Med Chem 2019 Feb 8. Epub 2019 Feb 8.

School of Molecular Sciences , Arizona State University. United States.

We review various mathematical and computational techniques for drug discovery exemplifying some recent works pertinent to group theory of nested structures of relevance to phylogeny, topological, computational and combinatorial methods for drug discovery for multiple viral infections. We have reviewed techniques from topology, combinatorics, graph theory and knot theory that facilitate topological and mathematical characterizations of protein-protein interactions, molecular-target interactions, proteomics, genomics and statistical data reduction procedures for a large set of starting chemicals in drug discovery. We have provided an overview of group theoretical techniques pertinent to phylogeny, protein dynamics especially in intrinsically disordered proteins, DNA base permutations and related algorithms. Read More

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http://dx.doi.org/10.2174/1568026619666190208164005DOI Listing
February 2019
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Epidemiology of viral hepatitis in the Maghreb.

Tunis Med 2018 Oct-Nov;96(10-11):606-619

Introduction: Viral hepatitis represents a serious public health problem in the world especially in the Maghreb where the prevalence of the 5 viruses A, B, C, D, and E remains high and varies from one Maghreb country to another, there is few published studies on these infections in our Maghreb countries.

Method Of Study: Our work is a review of the literature about prevalence, the most common mode of transmission, and the most exposed population for these viruses in the Maghreb countries through published studies between 2011 and 2017.

Result: It has been found that the Maghreb countries are endemic for the five viruses with variable prevalence from one country to another, with sometimes heterogeneous data in the same country. Read More

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February 2019
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Receipt of Preventive Care Services Among US Adults with Inflammatory Bowel Disease, 2015-2016.

Dig Dis Sci 2019 Feb 12. Epub 2019 Feb 12.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop F-78, 4770 Buford Highway NE, Atlanta, GA, 30341, USA.

Background: Previous reports suggest that adults with inflammatory bowel disease (IBD) receive suboptimal preventive care.

Aims: The population-based study compared the receipt of these services by US adults with and without IBD.

Methods: Adults aged ≥ 18 years with IBD (1. Read More

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http://link.springer.com/10.1007/s10620-019-05494-w
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http://dx.doi.org/10.1007/s10620-019-05494-wDOI Listing
February 2019
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Hepatitis C Infection in Hemodialysis Patients.

Curr Health Sci J 2018 Apr-Jun;44(2):107-112. Epub 2018 Mar 27.

Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania.

Three centuries after the identification of hepatitis C virus (HCV), specialized literature has outlined the epidemiology, viral kinetics and clinical manifestations of this infection. A major cause of morbidity-mortality in patients with renal transplantation and in hemodialysis patients is HCV infection. In high seroprevalence countries, internal accounts are not uniform. Read More

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http://dx.doi.org/10.12865/CHSJ.44.02.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320456PMC

Bone Health in Patients With Liver Diseases.

J Clin Densitom 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA USA. Electronic address:

Osteoporosis is the most common bone disease in chronic liver disease (CLD) resulting in frequent fractures and leading to significant morbidity in this population. In addition to patients with cirrhosis and chronic cholestasis, patients with CLD from other etiologies may be affected in the absence of cirrhosis. The mechanism of osteoporosis in CLD varies according to etiology, but in cirrhosis and cholestatic liver disease it is driven primarily by decreased bone formation, which differs from the increased bone resorption seen in postmenopausal osteoporosis. Read More

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http://dx.doi.org/10.1016/j.jocd.2019.01.004DOI Listing
January 2019
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Priorities and recommended actions for how researchers, practitioners, policy makers, and the affected community can work together to improve access to hepatitis C care for people who use drugs.

Int J Drug Policy 2019 Feb 8;66:87-93. Epub 2019 Feb 8.

The Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia. Electronic address:

It is estimated that 6.1 million people with recent injecting drug use (PWID) are living with hepatitis C virus (HCV). Although HCV-related morbidity and mortality among PWID continues to increase, the advent of direct acting antiviral (DAA) HCV regimens with cure rates >95% provides an opportunity to reverse the rising burden of disease. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.01.012DOI Listing
February 2019
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High Clustering of Acute HCV Infections and High Rate of Associated STIs Among Parisian HIV-Positive Male Patients.

Int J Antimicrob Agents 2019 Feb 8. Epub 2019 Feb 8.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Hôpital Pitié-Salpêtrière, Department of Infectious Diseases, F-75013 Paris, France.

Background: Increasing incidence of hepatitis C virus (HCV) infection in HIV-positive men having sex with men (MSM) has been described in recent years. We performed phylogenetic analyses of acute HCV infections to characterize the dynamics during the epidemic in Paris and evaluated associated sexually transmitted infections (STI).

Methods: Sanger Sequencing of polymerase gene was performed. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.002DOI Listing
February 2019
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Mortality risk in the population of HIV-positive individuals in Southern China: A cohort study.

PLoS One 2019 11;14(2):e0210856. Epub 2019 Feb 11.

Guangxi Health and Family Planning Committee, Nanning, China.

To evaluate the mortality risk in the HIV-positive population, we conducted an observational cohort study involving routine data collection of HIV-positive patients who presented at HIV clinics and multiple treatment centers throughout Guangxi province, Southern China in 2011. The patients were screened for tuberculosis (TB) and tested for hepatitis B (HBV) and C (HCV) virus infections yearly. Following the registration, the cohort was followed up for a 60-month period till the end-point (December 31, 2015). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210856PLOS
February 2019
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