124,649 results match your criteria Hepatitis Viral

[Unusual cause of a PCT-elevation].

Dtsch Med Wochenschr 2021 Jun 15;146(12):818-820. Epub 2021 Jun 15.

Klinik für Innere Medizin II, Universitätsklinikum Freiburg.

Introduction:  Procalcitonin (PCT) is an established marker for bacterial infection. Elevation of PCT can occur due to various reasons and is not specific, as we outline in the following case report.

History:  We report on a 29 year old patient, who was presented by the psychiatric department because of obscure abdominal pain, nausea and vomiting since two days. Read More

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Identification of natural compounds extracted from crude drugs as novel inhibitors of hepatitis C virus.

Biochem Biophys Res Commun 2021 Jun 11;567:1-8. Epub 2021 Jun 11.

Department of Virology II, National Institute of Infectious Diseases, 162-8640, Tokyo, Japan. Electronic address:

Natural product-derived crude drugs are expected to yield an abundance of new drugs to treat infectious diseases. Hepatitis C virus (HCV) is an oncogenic virus that significantly impacts public health. In this study, we sought to identify anti-HCV compounds in extracts of natural products. Read More

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MHC Phosphopeptides: Promising targets for immunotherapy of cancer and other chronic diseases.

Mol Cell Proteomics 2021 Jun 12:100112. Epub 2021 Jun 12.

Department of Chemistry, University of Virginia, Charlottesville, VA, USA; Department of Pathology, University of Virginia, Charlottesville, VA, USA. Electronic address:

Major histocompatibility complex (MHC)-associated peptides have been considered as potential immunotherapeutic targets for many years. MHC class I phosphopeptides result from dysregulated cell signaling pathways that are common across cancers and both viral and bacterial infections. These antigens are recognized by central memory T-cells from healthy donors, indicating that they are considered antigenic by the immune system and that they are presented across different individuals and diseases. Read More

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SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome.

Clin Sci (Lond) 2021 Jun 15. Epub 2021 Jun 15.

The Key Laboratory of Molecular Biology of Infectious Diseases designated by the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.

Chronic HBV infection is a significant public health burden worldwide. HBV cccDNA organized as a minichromosome in nucleus is responsible for viral persistence and is the key obstacle for a cure of chronic hepatitis B. Recent studies suggest cccDNA transcription is epigenetically regulated by histone modifications, especially histone acetylation and methylation. Read More

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Safety of COVID-19 vaccines, their components or their platforms for pregnant women: A rapid review.

medRxiv 2021 Jun 6. Epub 2021 Jun 6.

Background: Pregnant women with COVID-19 are at an increased risk of severe COVID-19 illness as well as adverse pregnancy and birth outcomes. Many countries are vaccinating or considering vaccinating pregnant women with limited available data about the safety of this strategy. Early identification of safety concerns of COVID-19 vaccines, including their components, or their technological platforms is therefore urgently needed. Read More

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TCF1 in T cell immunity: a broadened frontier.

Nat Rev Immunol 2021 Jun 14. Epub 2021 Jun 14.

Center for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.

TCF1 and its homologue LEF1 are historically known as effector transcription factors downstream of the WNT signalling pathway and are essential for early T cell development. Recent advances bring TCF1 into the spotlight for its versatile, context-dependent functions in regulating mature T cell responses. In the cytotoxic T cell lineages, TCF1 is required for the self-renewal of stem-like CD8 T cells generated in response to viral or tumour antigens, and for preserving heightened responses to checkpoint blockade immunotherapy. Read More

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Programmable icosahedral shell system for virus trapping.

Nat Mater 2021 Jun 14. Epub 2021 Jun 14.

Department of Physics, Technical University of Munich, Munich, Germany.

Broad-spectrum antiviral platforms that can decrease or inhibit viral infection would alleviate many threats to global public health. Nonetheless, effective technologies of this kind are still not available. Here, we describe a programmable icosahedral canvas for the self-assembly of icosahedral shells that have viral trapping and antiviral properties. Read More

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Differential Alterations in the Attentional Networks of People Living with HIV and Apathy: Preliminary Results and Pharmacoclinical Impact.

CNS Spectr 2021 Apr;26(2):143

Maimonides University, Buenos Aires, Argentina.

Objective: The objective was to determine alterations in the care of people living with human immunodeficiency virus (PLHIV) with depressive disorder without and with apathy to determine differential parameters.

Methods: We studied 69 PLHIV, negativized viral load, of both sexes (19 women and 44 men), with depressive disorder (F32.9-DSM IV), 20 with apathy and 26 without apathy; negativized viral load, in highly effective antiretroviral treatment without therapeutic failure in the last 2 years and without protease inhibitors; without psychopharmacological treatment (except anxiolytics) or dementia due to HIV (American Academy of Neurology) or comorbidities (hepatitis C, CNS or central vascular infections). Read More

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Antiviral activities of flavonoids.

Biomed Pharmacother 2021 Jun 11;140:111596. Epub 2021 Jun 11.

Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. Electronic address:

Flavonoids are natural phytochemicals known for their antiviral activity. The flavonoids acts at different stages of viral infection, such as viral entrance, replication and translation of proteins. Viruses cause various diseases such as SARS, Hepatitis, AIDS, Flu, Herpes, etc. Read More

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Evidence-based management of HCC: Systematic review and meta-analysis of randomized controlled trials (2002-2020).

Gastroenterology 2021 Jun 11. Epub 2021 Jun 11.

Mount Sinai Liver Cancer Program, [Division of Liver Diseases, RMTI, Dept of Radiology, Hematology/Medical Oncology,] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Translational Research in Hepatic Oncology, Liver Unit, IDIBAPS, Hospital Clinic, University of Barcelona, Catalonia, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address:

Background And Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality with a rapidly changing landscape of treatments. In the past 20 years, numerous randomized controlled trials (RCT) have aimed at improving outcomes across disease stages. We aimed at analyzing the current evidence and identifying potential factors influencing response to therapies. Read More

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Significance of hepatitis B surface antigen, IgM/IgG core antibody and hepatitis B virus DNA in blood donors.

Gac Med Mex 2021 ;157(1):35-40

Blood Banks Referral Unit, Centro de Investigación para la Salud en América Latina.

Introduction: Identification of hepatitis B virus carriers in blood donors is imperative in order to avoid transmission of the disease via blood transfusion.

Objective: To determine if blood donors with positive results for serological markers HBsAg and anti-HBc were hepatitis B virus DNA carriers.

Methods: 12,745 samples were collected from six Ecuadorian blood banks and analyzed for HBsAg, anti-HBc and anti-HBs infectious markers by automated ELISA. Read More

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January 2021

Universal Screening for Hepatitis C Virus in the ED Using a Best Practice Advisory.

West J Emerg Med 2021 May 14;22(3):719-725. Epub 2021 May 14.

UC Davis Health, Department of Emergency Medicine, Sacramento, California.

Introduction: In 2019 the United States Preventive Services Task Force (USPSTF) released draft guidelines recommending universal hepatitis C virus (HCV) screening for individuals aged 18-79. We aimed to assess the efficacy of an emergency department-based HCV screening program, by comparing screening practices before and after its implementation.

Methods: We performed a retrospective cohort analysis of two temporally matched, 11-month study periods, corresponding to before and after the implementation of a best practice advisory (BPA). Read More

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Chronic viral hepatitis, HIV infection and Non-Hodgkin lymphomas in West Africa, a case-control study.

Int J Cancer 2021 Jun 14. Epub 2021 Jun 14.

Service d'hématologie, Centre Hospitalier Universitaire de Yopougon, Abidjan, Côte d'Ivoire.

Non-Hodgkin lymphomas (NHL) are underestimated causes of cancer in West Africa where chronic viral hepatitis and HIV are endemic. While the association with HIV infection has already been characterized, limited information is available on the association between chronic viral hepatitis and NHL in sub-Saharan Africa. A case-control study was conducted in referral hospitals of Abidjan (Cote d'Ivoire) and Dakar (Senegal). Read More

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A nurse practitioner model of care in the era of direct acting antiviral therapy for hepatitis C virus infection.

JGH Open 2021 Jun 20;5(6):669-672. Epub 2021 May 20.

Gosford Hospital, Central Coast Local Health District Gosford New South Wales Australia.

Background And Aim: Direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection has resulted in high rates of successful disease cure; however, not enough healthcare providers are available to deliver treatment to the population living with chronic HCV. To demonstrate that a nurse practitioner (NP) model of care is non-inferior to specialist gastroenterologist (SG) management of HCV infection, as measured by sustained viral response at 12 weeks (SVR) after initiation of DAA therapy.

Design: Retrospective cohort database study. Read More

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A Sensitive and Specific PCR-based Assay to Quantify Hepatitis B Virus Covalently Closed Circular (ccc) DNA while Preserving Cellular DNA.

Bio Protoc 2021 Apr 20;11(8):e3986. Epub 2021 Apr 20.

Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.

Hepatitis B virus (HBV) is the major cause of liver diseases and liver cancer worldwide. After infecting hepatocytes, the virus establishes a stable episome (covalently closed circular DNA, or cccDNA) that serves as the template for all viral transcripts. Specific and accurate quantification of cccDNA is difficult because infected cells contain abundant replicative intermediates of HBV DNA that share overlapping sequences but arranged in slightly different forms. Read More

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Developing and Piloting a Standardized European Protocol for Hepatitis C Prevalence Surveys in the General Population (2016-2019).

Front Public Health 2021 28;9:568524. Epub 2021 May 28.

Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.

A robust estimate of the number of people with chronic hepatitis C virus (HCV) infection is essential for an appropriate public health response and for monitoring progress toward the WHO goal of eliminating viral hepatitis. Existing HCV prevalence studies in the European Union (EU)/European Economic Area (EEA) countries are heterogeneous and often of poor quality due to non-probability based sampling methods, small sample sizes and lack of standardization, leading to poor national representativeness. This project aimed to develop and pilot standardized protocols for undertaking nationally representative HCV prevalence surveys in the general adult population. Read More

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A Curious Case of Acute Acalculous Cholecystitis.

Cureus 2021 May 10;13(5):e14948. Epub 2021 May 10.

Internal Medicine, University of California Los Angeles, Los Angeles, USA.

Acute acalculous cholecystitis is inflammation of the gallbladder without any evidence of gallstones. Although acalculous cholecystitis is less common than its calculous counterpart, it can be fatal if not treated. It is essential to rule out the cause of acalculous cholecystitis to aid in the treatment and management of the patient. Read More

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Guillain-Barré Syndrome Likely due to Relapsing Hepatitis A.

Case Reports Hepatol 2021 26;2021:5570027. Epub 2021 May 26.

Department of Internal Medicine, Methodist Dallas Medical Center, Dallas, TX 75203, USA.

Guillain-Barré syndrome (GBS) is an immune-mediated disease of the peripheral nervous system that can be caused by various bacterial and virologic agents. The disease is characterized by progressive muscle weakness and paralysis. Rarely, GBS is preceded by an acute infection with hepatitis A. Read More

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Animal and Organoid Models of Liver Fibrosis.

Front Physiol 2021 26;12:666138. Epub 2021 May 26.

Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, China.

Liver fibrosis refers to the process underlying the development of chronic liver diseases, wherein liver cells are repeatedly destroyed and regenerated, which leads to an excessive deposition and abnormal distribution of the extracellular matrix such as collagen, glycoprotein and proteoglycan in the liver. Liver fibrosis thus constitutes the pathological repair response of the liver to chronic injury. Hepatic fibrosis is a key step in the progression of chronic liver disease to cirrhosis and an important factor affecting the prognosis of chronic liver disease. Read More

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Correlation Between Serum Ferritin and Viral Hepatitis in Thalassemia Patients.

Hemoglobin 2021 Jun 14:1-5. Epub 2021 Jun 14.

Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Serum ferritin is an acute phase protein; importantly, its level is noticeably increased in response to iron overload and systemic inflammation. The iron overload status in thalassemia patients has been recognized as a potential way to measure liver iron concentration (LIC) levels using magnetic resonance imaging (MRI). The aim of this study was to investigate the effect of chronic viral hepatitis on the level of serum ferritin in patients with thalassemia. Read More

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Hepatitis B and Hepatitis C among Adults on Probation or Parole in the United States: 2015-2018.

J Health Care Poor Underserved 2021 ;32(2):671-679

Background: Viral hepatitis is highly prevalent in U.S. prison populations, but prevalence has not been described among adults on probation/parole. Read More

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January 2021

Autophagy in liver diseases: A review.

Mol Aspects Med 2021 Jun 10:100973. Epub 2021 Jun 10.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA. Electronic address:

The liver is a highly dynamic metabolic organ that plays critical roles in plasma protein synthesis, gluconeogenesis and glycogen storage, cholesterol metabolism and bile acid synthesis as well as drug/xenobiotic metabolism and detoxification. Research from the past decades indicate that autophagy, the cellular catabolic process mediated by lysosomes, plays an important role in maintaining cellular and metabolic homeostasis in the liver. Hepatic autophagy fluctuates with hormonal cues and the availability of nutrients that respond to fed and fasting states as well as circadian activities. Read More

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Time for universal hepatitis B screening for Australian adults.

Med J Aust 2021 Jun 13. Epub 2021 Jun 13.

WHO Collaborating Centre for Viral Hepatitis, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC.

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Two-stage exchange Arthroplasty for knee Periprosthetic joint infection exhibit high infection recurrence rate in patients with chronic viral hepatitis.

BMC Musculoskelet Disord 2021 Jun 12;22(1):538. Epub 2021 Jun 12.

Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan.

Background: Currently, there is little evidence about the outcome of two-stage exchange arthroplasty for the treatment of knee periprosthetic joint infection (PJI) in patients with chronic viral hepatitis. To evaluate it, we set the primary outcome as infection recurrence, and the secondary outcome as the difference between patients diagnosed with hepatitis B virus or hepatitis C virus.

Patients And Methods: Between June, 2010 and December, 2016, 172 patients with knee PJIs were treated with two-stage exchange arthroplasty at our institute. Read More

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Immunological and virological discordance among people living with HIV on highly active antiretroviral therapy in Tigray, Northern Ethiopia.

BMC Infect Dis 2021 Jun 12;21(1):561. Epub 2021 Jun 12.

Department of Medical Microbiology and Immunology, College of Health Sciences, Mekelle University, Mek'ele, Tigray, Ethiopia.

Background: People living with human immunodeficiency virus (HIV) with immuno-virological discordant responses are at an increased risk to develop acquired immunodeficiency syndrome (AIDS) and severe non AIDS events which are risk factors for death. This study was aimed to assess prevalence of immuno- virological discordant responses and associated risk factors among highly active antiretroviral therapy (HAART) users in Tigray, Northern Ethiopia.

Methods: A cross sectional study was conducted from September to December 30, 2016 on 260 people living with HIV who started first line HAART from January 2008 to March 2016 at Mekelle hospital and Ayder comprehensive specialized hospital. Read More

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An evaluation of StaySafe, a tablet app to improve health risk decision-making among people under community supervision.

J Subst Abuse Treat 2021 May 14;130:108480. Epub 2021 May 14.

Texas Christian University, Institute of Behavioral Research, TCU Box 298740, Fort Worth, TX 76129, USA. Electronic address:

Background: A self-administered tablet app, StaySafe, helps people under community supervision to make better decisions regarding health risk behaviors, especially those linked to HIV, viral hepatitis, and other sexually transmitted infections. The multi-session StaySafe design uses an interactive, analytical schema called WORKIT that guides users through a series of steps, questions, and exercises aimed at promoting critical thinking about health risks associated with substance use and unprotected sex. Repetition of the WORKIT schema is designed to enhance procedural memory that can be rapidly accessed when individuals are faced with making decisions about risky behaviors. Read More

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Pregnancy and viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 10;1867(10):166198. Epub 2021 Jun 10.

Fetal and Perinatal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant - "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy. Electronic address:

Some maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Read More

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Natural killer cells in antiviral immunity.

Nat Rev Immunol 2021 Jun 11. Epub 2021 Jun 11.

Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Natural killer (NK) cells play an important role in innate immune responses to viral infections. Here, we review recent insights into the role of NK cells in viral infections, with particular emphasis on human studies. We first discuss NK cells in the context of acute viral infections, with flavivirus and influenza virus infections as examples. Read More

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Characterization and prediction of viral loads of Hepatitis B serum samples by using surface-enhance Raman spectroscopy (SERS).

Photodiagnosis Photodyn Ther 2021 Jun 8:102386. Epub 2021 Jun 8.

PCR Laboratory, PINUM Hospital, Faisalabad, Pakistan.

Background: Raman spectroscopy is a promising technique to analyze the body fluids for the purpose of non-invasive disease diagnosis.

Objectives: To develop a surface-enhanced Raman spectroscopy (SERS) based method for qualitative and quantitative analysis of hepatitis B viral (HBV) infection from blood serum samples.

Methods: Clinically diagnosed hepatitis B virus (HBV) infected serum samples of patients of different levels of viral loads have been subjected for SERS analysis in comparison with the healthy ones by using silver nanoparticles (Ag NPs) based SERS substrates. Read More

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