242,242 results match your criteria Hepatitis Viral


Serologic Status of Routine Childhood Vaccines, Cytomegalovirus, and Epstein-Barr Virus in Children With Inflammatory Bowel Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Section of Paediatric Gastroenterology, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.

Background: Data on the serologic status of childhood vaccines, cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are limited in inflammatory bowel disease (IBD). Therefore, we evaluated vaccine coverage and seroprotection, along with CMV and EBV seropositivity, in pediatric IBD.

Methods: In a cross-sectional study, demographic data, IBD history, vaccine records, and serum for antibodies against measles, mumps, rubella, diphtheria, tetanus, varicella, hepatitis B (HBV), CMV, and EBV were collected from children with IBD. Read More

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December 2018

Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway.

Free Radic Biol Med 2018 Dec 11. Epub 2018 Dec 11.

Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Electronic address:

Chronic hepatitis B virus (HBV) infection remains a serious global health concern. Cisplatin is a chemotherapeutic agent commonly used to treat various cancers. However, HBV-infected patients receiving chemotherapy are at risk of HBV reactivation via unknown mechanisms, which we aimed to elucidate in this study. Read More

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December 2018

Recovery of metabolic impairment of patients who cleared HCV infections after direct-acting antiviral therapy.

Int J Antimicrob Agents 2018 Dec 11. Epub 2018 Dec 11.

National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS- Via Portuense, 292- 00149 Rome, Italy. Electronic address:

Chronic Hepatitis C (CHC) is a complex disease that can affect different metabolic processes, including glucose and lipids metabolic pathways, with a significant impact on development of heart disease and stroke. The recent therapy with Direct Antiviral Agents (DAAs) beyond the high efficacy on CHC eradication, showed a beneficial impact on glucose and lipid metabolism. This review aims to describe current evidences about the association between HCV infection and impairment of glucose and lipids metabolism and discuss potential public health implications at the light of new DAA therapy and their availability at global level. Read More

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December 2018

Full-genome analysis of hepatitis C virus in Japanese and non-Japanese patients coinfected with HIV-1 in Tokyo.

J Acquir Immune Defic Syndr 2018 Dec 6. Epub 2018 Dec 6.

AIDS Clinical Center and.

Background: Acute hepatitis C virus (HCV) infection is increasing among HIV-1-infected individuals in Tokyo. Appropriate clinical management is needed.

Setting: To delineate the epidemiological status of HCV transmission, we analyzed stocked plasma samples of HCV/HIV-1-coinfected patients seen at the largest referral center for HIV care in Tokyo. Read More

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December 2018

Pulmonary hypertension in patients with a history of intravenous drug use.

Curr Med Res Opin 2018 Dec 14:1-14. Epub 2018 Dec 14.

a Cardiovascular Department , John Hunter Hospital , Newcastle NSW , Australia.

Objective: Pulmonary hypertension may be a consequence of intrinsic elevation in pulmonary vasculature resistance or complicate numerous other conditions affecting the cardiac and respiratory systems. In this review we sought to explore the relationship between pulmonary hypertension and intravenous drug use.

Methods: A narrative review was conducted using PubMed MeSH search with further papers were identified using a standard PubMed search with relevant key terms and various synonyms. Read More

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December 2018

Label-free Proteomic Analysis of Exosomes Secreted from THP-1-derived Macrophages Treated with IFN-╬▒ Identifies Antiviral Proteins Enriched in Exosomes.

J Proteome Res 2018 Dec 14. Epub 2018 Dec 14.

Exosomes are extracellular vesicles that function in intercellular communication. We have previously reported that exosomes play an important role in the transmission of antiviral molecules during interferon-╬▒ (IFN-╬▒) treatment. In this study, the protein profiles of THP-1-derived macrophages with or without interferon-╬▒ treatment and the exosomes secreted from these cells were analyzed by label-free LC-MS/MS quantitation technologies. Read More

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December 2018

[Biological risk in agriculture and construction workplaces: a survey on perception, knowledge and prevention measures.]

G Ital Med Lav Ergon 2018 Dec;40(4):195-202

Cattedra di Igiene, Dipartimento di Medicina e Scienze per la Salute "Vincenzo Tiberio", Università degli Studi del Molise.

Objectives: Despite the potential presence in many workplaces, biological risk is little known and largely underestimated, except in healthcare environments. Objectives: To evaluate perception, knowledge and behaviors adopted for protection and prevention of biological risk, related also to the occupational activity, among construction and agricultural workers.

Methods: Workers were recruited at farms and construction companies of Molise Region, Central Italy, which were visited within the surveillance activities planned by local institutions. Read More

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December 2018

A Special Risk Group for Hepatitis E Infection: The First Record of North Cyprus.

Pol J Microbiol 2018 ;67(4):525-528

Department of Biophysics, Faculty of Medicine, Near East University , Nicosia , Cyprus.

Hepatitis E virus (HEV) is transmitted by a fecal oral route from animals to humans following exposure to the body fluids of infected animals. We investigated the seroprevalence of anti-hepatitis E (anti-HEV) antibodies by monitoring IgG and IgM virus antibodies amongst employees in the animal industry in North Cyprus through a cross-sectional study. Samples were taken from individuals without occupational exposure to animals and from those who worked with animals (doing animal husbandry, veterinary work or butchery). Read More

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January 2018

Transplantation of Livers from Old Donors: Pushing the Envelope Beyond the Seventh Decade.

Isr Med Assoc J 2018 Dec;20(12):765-769

Department of Transplantation, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.

Background: The lack of organs for liver transplantation has prompted transplant professionals to study potential solutions, such as the use of livers from donors older than 70 years. This strategy is not widely accepted because potential risks of vascular and biliary complications and recurrence of hepatitis C.

Objectives: To examine the efficacy and safety of liver grafts from older donors for transplantation. Read More

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December 2018

Changes in Prealbumin and Body Mass Index Associated with T Lymphocyte Subsets and Nutritional Status in Chronic Hepatitis B and HBV-Cirrhosis Patients.

Clin Lab 2018 Oct;64(11)

Background: Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate the relationship between the nutritional status and immune function, and to provide the appropriate clinical diagnosis data for treatment of patients with chronic hepatitis B virus (CHB) and cirrhosis. Methods: T lymphocyte subsets were tested using flow cytometry in 100 patients (48 with CHB, 52 with cirrhosis) and 26 healthy individuals. Read More

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October 2018

High prevalence of binge drinking among people living with HIV in four African countries.

J Int AIDS Soc 2018 Dec;21(12):e25202

Service de maladies infectieuses et tropicales, CRCF, CHU de Fann, Dakar, S├ęn├ęgal.

Introduction: Excessive alcohol consumption leads to unfavourable outcomes in people living with HIV (PLHIV), including reduced adherence to antiretroviral therapy (ART) and engagement into care. However, there is limited information on alcohol consumption patterns among PLHIV in sub-Saharan Africa.

Methods: Using a cross-sectional approach, the Alcohol Use Disorders Identification Test (AUDIT-C) was administered to PLHIV attending HIV clinics in C├┤te d'Ivoire, Togo, Senegal and Zambia (2013 to 2015). Read More

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December 2018

Tolerability and effectiveness of generic direct-acting antiviral drugs in eradication of hepatitis C genotype 4 among Egyptian patients.

Liver Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Tropical Medicine, Faculty of Medicine, Al-Azhar University Cairo, Egypt.

Background: We investigated tolerability and effectiveness of generic, less expensive direct antiviral drugs in the treatment of hepatitis C virus genotype 4(HCV- GT-4) in an Egyptian cohort.

Patients And Methods: Retrospectively, we analyzed data from 648 patients with HCV-GT4 attending Alexandria Main University Hospital from January 2016 to May 2017 [488 treatment naïve/160 treatment experienced/288 with chronic hepatitis/360 with cirrhosis]. Patients received generic sofosbuvir/ledipasvir (n= 168, treatment naïve = 136, treatment-experienced = 32) or sofosbuvir/daclatasvir (n= 480, treatment naïve = 352, treatment-experienced = 128) ± ribavirin. Read More

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December 2018

The presence of varices in patients after hepatitis C eradication predicts deterioration in the FIB-4 index.

Hepatol Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto.

Aims: The liver function of patients with hepatitis C virus (HCV) infection who obtained sustained virological response (SVR) has been known to improve after HCV eradication. However, a predictor of liver function after SVR has not been definitively identified. The aim of this retrospective study was to identify a predictor of deteriorated liver function and FIB-4 index after SVR was achieved by direct-acting antiviral (DAA) treatment. Read More

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December 2018

Pharmacological induction of a progenitor state for the efficient expansion of primary human hepatocytes.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

School of Life Sciences, Ecole Polytechnique F├ęd├ęrale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

The liver is an organ with strong regenerative capacity, yet primary hepatocytes have a low amplification potential in vitro, a major limitation for the cell-based therapy of liver disorders and for ex vivo biological screens. Induced pluripotent stem cells (iPSC) may help to circumvent this obstacle, but often harbor genetic and epigenetic abnormalities limiting their potential. Here, we describe the pharmacological induction of proliferative human hepatic progenitor cells (HPC) through a cocktail of growth factors and small molecules mimicking the signaling events involved in liver regeneration. Read More

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December 2018

Entecavir and peginterferon alfa-2a in adults with HBeAg-positive immune tolerant chronic hepatitis B virus infection.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

University of Michigan.

Background/aim: Monotherapy with interferon or nucleoside analog is generally not recommended during the immune tolerant (IT) phase of chronic hepatitis B virus (HBV) infection. Recognition that high HBV DNA levels are associated with hepatocellular carcinoma has increased interest in treating HBV in the IT phase. Small pediatric studies reported efficacy with combination nucleoside analog and interferon therapy. Read More

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December 2018

MicroRNAs: Unfolding the link between inositol-requiring enzyme 1╬▒ and fatty liver.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Northwestern University Feinberg School of Medicine.

Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver chemistry tests in the United States and western world. The mechanisms underlying hepatic steatosis and the progression to nonalcoholic steatohepatitis (NASH) remain incompletely understood. Multiple cellular stress pathways are believed to contribute to the pathogenesis of fatty liver, including endoplasmic reticulum (ER) stress and its adaptive unfolded protein response (UPR). Read More

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December 2018

Sofosbuvir and Ribavirin eradication of refractory hepatitis E in an immunosuppressed kidney transplant recipient.

Hepatology 2018 Dec 14. Epub 2018 Dec 14.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

Hepatitis E virus (HEV) infection is a self-limited asymptomatic illness in immunocompetent patients, but may cause chronic infection in immunosuppressed, solid organ transplant recipients. Chronic HEV can result in aggressive inflammation and fibrosis, leading to cirrhosis in up to 10%(1). Current therapy has been limited to reducing immunosuppression and/or ribavirin which leads to viral clearance in 64-74% of patients. Read More

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December 2018

Considering hepatitis C virus infection as a systemic disease.

Semin Dial 2018 Dec 13. Epub 2018 Dec 13.

UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universit├ęs, UPMC Univ Paris 06, Paris, France.

Hepatitis C virus (HCV) infection has been demonstrated to result in several adverse hepatic outcomes and has been associated with a number of important extrahepatic manifestations. The scope of extrahepatic clinical possibilities includes systemic diseases such as vasculitis and lymphoproliferative disorders, cardiovascular disease, myalgia, arthritis, and sicca syndrome. These end-organ effects of HCV may dominate the clinical course beyond the hepatic complications and significantly worsen the long-term prognosis of infected patients. Read More

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December 2018

Ef´Čücacy and safety of sofosbuvir-based therapy in hepatitis C virus recurrence post living donor liver transplant: A real life egyptian experience.

J Med Virol 2018 Dec 14. Epub 2018 Dec 14.

Department of Endemic Medicine and Hepatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Aim: Direct acting antiviral has offered treatment of hepatitis C virus (HCV) recurrence post liver transplantation (LT) with an all-oral regimen for short duration, excellent safety profile, and high sustained virological response (SVR). The aim of this study was to evaluate the efficacy and safety of sofosbuvir (SOF)-based regimens in the real world among a cohort of Egyptian patients with recurrent HCV post living donor LT (LDLT).

Methods: Patients with HCV-G4 recurrence post-LDLT were recruited from National Committee of Control of Viral Hepatitis, Egypt, from November 2014 to May 2017. Read More

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December 2018

Hepatitis E virus blood donor NAT screening: as much as possible or as much as needed?

Transfusion 2018 Dec 13. Epub 2018 Dec 13.

Institut f├╝r Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein- Westfalen, Universit├Ątsklinik der Ruhr-Universit├Ąt Bochum, Bad Oeynhausen, Germany.

Background: The cost-benefit question of general screening of blood products for the hepatitis E virus (HEV) is currently being discussed. One central question is the need for individual nucleic acid amplification techniques (NAT) screening (ID-NAT) versus minipool NAT screening (MP-NAT) approaches to identify all relevant viremias in blood donors. Here, the findings of ID-NAT versus MP-NAT in pools of 96 samples were compared. Read More

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December 2018

Inhibition of Hepatitis C replication by targeting the molecular chaperone Hsp90 - synthesis and biological evaluation of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole derivatives.

ChemMedChem 2018 Dec 13. Epub 2018 Dec 13.

University of Helsinki, Centre for Drug Research, Division of Pharmaceutical Biosciences, Viikinkaari 4, 00014, Helsinki, FINLAND.

Cellular chaperones that belong to the heat-shock protein 90 (Hsp90) family are a prerequisite for successful viral propagation for most viruses. The hepatitis C virus (HCV) uses Hsp90 for maturation, folding and modification of viral proteins. Based on our previous discovery that marine alkaloid analogues with 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2-amine structure show inhibition of HCV replication and potential binding to Hsp90, a series of twelve novel compounds based on this scaffold was designed and synthesized. Read More

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December 2018

Uptake of direct acting antiviral therapies for the treatment of hepatitis C virus among people who inject drugs in a universal health-care system.

Drug Alcohol Rev 2018 Dec 12. Epub 2018 Dec 12.

National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.

Introduction And Aims: Direct acting antiviral (DAA) treatment can reduce hepatitis C virus (HCV) infection incidence and mortality, although large scale uptake of these treatments is necessary to achieve those reductions. Targeting people who inject drugs (PWID) will be crucial to achieve the necessary reductions. Previously, treatment uptake has been very low (1-2%) among PWID, but these new DAAs have been subsidised in Australia since March 2016. Read More

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December 2018

Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Chronic hepatitis (CH) in dogs is common and has the tendency to progress to liver cirrhosis (LC). Circulating microRNAs might have the potential as markers for disease progression.

Objectives: To investigate whether concentration of specific microRNAs in serum correlate with the stage and grade of CH in Labrador Retrievers. Read More

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December 2018

Editorial: comorbidities, concomitant medications, and potential drug-drug interactions with interferon-free direct-acting anti-viral agents in chronic hepatitis C.

Aliment Pharmacol Ther 2019 Jan;49(1):116-117

Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University School of Medicine, Aichi, Japan.

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January 2019

Sofosbuvir Plus Ribavirin for the Treatment of Hepatitis C Virus Genotype 2 in Korea: What's the optimal dosage of ribavirin in real-world setting?

J Dig Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Internal Medicine, Mokpo Hankook Hospital, Mokpo, South Korea.

Aim: The objectives of this study were to examine the efficacy and safety of sofosbuvir plus ribavirin therapy for the treatment of hepatitis C virus genotype 2 infection and to determine the optimal ribavirin dosage.

Methods: From May 2016 to March 2017, 199 patients received sofosbuvir plus ribavirin treatment for hepatitis C virus genotype 2 infection at four centers in Jeollanam-do. After excluding patients lost to follow-up and those with insufficient data, we retrospectively assessed the data for 194 patients. Read More

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December 2018

Incidence of hepatitis E virus infection among blood donors in a high endemic area of Central Italy.

J Viral Hepat 2018 Dec 7. Epub 2018 Dec 7.

Department of Infectious Diseases, National Institute of Health, Rome, Italy.

In Europe, autochthonous hepatitis E virus (HEV) infection is mainly a food-borne zoonosis, but it is also transmitted by blood transfusion. Despite the numerous prevalence surveys, only a few studies have investigated HEV incidence. We aimed to determine HEV incidence and risk factors among blood donors in a hyperendemic area in Central Italy. Read More

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December 2018

Hepatitis E virus infection in swine workers: A meta-analysis.

Zoonoses Public Health 2018 Dec 10. Epub 2018 Dec 10.

Department of Epidemiology, Fudan University School of Public Health, Key Laboratory of Public Health Safety (Ministry of Education), Shanghai, China.

Hepatitis E virus (HEV) infects both humans and animals. Swine has been confirmed to be the principal natural reservoir, which raises a concern that HEV infection would be substantially increasing among swine workers. The present study calculated the pooled prevalence of IgG antibodies against HEV among swine workers and the general population in previous cross-sectional studies. Read More

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December 2018

Role of soluble inflammatory mediators and different immune cell populations in early control of symptomatic acute hepatitis C virus infection.

J Viral Hepat 2018 Dec 8. Epub 2018 Dec 8.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

The natural course of acute Hepatitis C Virus (aHCV) infection is highly heterogeneous and only few biomarkers have been identified to reliably predict the outcome of infection. We analyzed a large panel of serum soluble inflammatory mediators, immune cell frequencies and phenotypes using peripheral blood samples from 26 patients with symptomatic aHCV infection from a controlled randomized. We found that patients with a spontaneous early HCV control demonstrated a distinct expression pattern of various soluble immune mediators including IFN╬▒ and IL-16. Read More

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December 2018

Hepatitis Delta Could Be More Frequent than Previously Thought.

AIDS Rev 2018 ;20(4):236

UNIR Health Sciences School and La Paz University Hospital Madrid, Spain.

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January 2018

Hepatitis E Virus, the Uninvited Intruder in Western Kitchens.

Authors:
Pablo Barreiro

AIDS Rev 2018 ;20(4):237-238

Hospital Carlos III- La Paz Madrid, Spain.

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January 2018

Rebound in Sexually Transmitted Infections Following the Success of Antiretrovirals for HIV/AIDS.

AIDS Rev 2018 ;20(4):187-204

Sexually Transmitted infections Unit, Centro Sanitario Sandoval. Madrid, Spain.

Nearly 1 million people become infected every day with any of the four major curable sexually transmitted infections (STIs), namely trichomoniasis, chlamydia, gonorrhea, and syphilis. Despite huge global incidence, STIs remain as neglected diseases. The success of antiretrovirals for halting progression to AIDS in HIV-infected individuals and for stopping HIV transmission to uninfected contacts, either as pre- or post-exposure -prophylaxis, has to lead to increased risky sexual behaviors through risk compensation. Read More

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January 2018

Should HIV Patients be concerned about Occult Hepatitis B?

AIDS Rev 2018 ;20(4):238-239

UNIR Health Sciences School and La Paz University Hospital Madrid, Spain.

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January 2018

Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis.

Eur Cytokine Netw 2018 Sep;29(3):112-120

AP-HP, h├┤pital Jean-Verdier, service d'h├ępatologie, Bondy, France, Inserm UMR_S┬á1162, ┬ź┬áG├ęnomique fonctionnelle des tumeurs solides┬á┬╗, 75005 Paris, France, Universit├ę Paris 13, Sorbonne Paris-Cit├ę, ┬ź┬á├ëquipe labellis├ęe Ligue contre le cancer┬á┬╗, 93206 Saint-Denis, France.

An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis. Read More

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September 2018

A hotspots analysis-relation discovery representation model for revealing diabetes mellitus and obesity.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):116. Epub 2018 Dec 14.

Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, College of Computer Science and Technology, Jilin University, Changchun, 130012, China.

Background: Nowadays, because of the huge economic burden on society causing by obesity and diabetes, they turn into the most serious public health challenges in the world. To reveal the close and complex relationships between diabetes, obesity and other diseases, search the effective treatment for them, a novel model named as representative latent Dirichlet allocation (RLDA) topic model is presented.

Results: RLDA was applied to a corpus of more than 337,000 literatures of diabetes and obesity which were published from 2007 to 2016. Read More

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December 2018

Pathogenicity and molecular characterization of a fowl adenovirus 4 isolated from chicken associated with IBH and HPS in China.

BMC Vet Res 2018 Dec 14;14(1):400. Epub 2018 Dec 14.

College of Veterinary Medicine, Hebei Agricultural University, Baoding, 071001, Hebei, China.

Background: Since July in 2015, an emerging infectious disease, Fowl adenovirus (FAdV) species C infection with Hepatitis-Hydropericardium syndrome was prevalent in chicken flocks in China. In our study, one FAdV strain was isolated from commercial broiler chickens and was designated as SDSX1.The phylogenetic information, genetic mutations and pathogenicity of SDSX1 were evaluated. Read More

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December 2018

Increased hepatitis C virus co-infection and injection drug use in HIV-infected fishermen in Myanmar.

BMC Infect Dis 2018 Dec 14;18(1):657. Epub 2018 Dec 14.

MSF, Geneva, Switzerland.

Background: In Southeast Asia, though fishermen are known to be a key population at high risk of HIV, little is known about their co-infection rates with Hepatitis C virus (HCV), or how illness and risk behaviors vary by occupation or type of fishermen. In Myanmar, this lack of knowledge is particularly acute, despite the fact that much of the country's border is coastline.

Methods: We conducted a retrospective analysis to assess clinical, demographic, and risk characteristics of HIV-infected, Ôëą15-year-old males under HIV care from 2004 to 2014. Read More

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December 2018

Studies on transmission of hepatitis A virus to squirrel monkeys.

Primates 2000 Apr;41(2):127-135

Departamento de Virologia, Instituto Oswaldo Cruz/FIOCRUZ, Av Brasil 4365, 21040-360, Rio de Janeiro, RJ, Brazil.

Non-human primates have been playing an essential role in the study of hepatitis A virus (HAV) biology, pathogenesis and for testing candidate HAV vaccines. This study was to determine the suitability of squirrel monkeys (Saimiri sciureus) as animal model for HAV infection. Animals were inoculated, either intragastrically or intravenously, with a Brazilian HAV isolate (HAF-203). Read More

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Risk Factors and Rates of Hepatitis B Virus Infection among Municipal Waste Management Workers and Scavengers in Ilorin, Kwara State, Nigeria.

J Health Pollut 2016 Dec 22;6(12):1-6. Epub 2016 Dec 22.

Centre for Ecological and Environmental Research Management Studies, Kwara State University, Malete, Nigeria.

Background: Poor municipal waste management, including waste treatment and disposal methods, threatens the environment and public health in most developing countries. Lack of proper municipal waste segregation and transportation techniques has increased the potential for the transmission of pathogens such as hepatitis B virus (HBV).

Objectives: This study addressed issues relating to the potential risk of infectious diseases and prevalence of HBV among municipal waste workers and scavengers in Ilorin metropolis, Nigeria. Read More

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December 2016

Health Care Facility Characteristics are Associated with Variation in Human Immunodeficiency Virus Pre-exposure Prophylaxis Initiation in Veteran's Health Administration.

AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.

VA Puget Sound Health Care System, Health Services Research and Development, Seattle, WA, USA.

To quantify health care facility-level variation in pre-exposure prophylaxis (PrEP) use in the Veteran's Health Administration (VHA); to identify facility characteristics associated with PrEP use. Retrospective analysis of the health care facility-level rate of PrEP initiation in VHA through June 30, 2017. Standardized PrEP initiation rates were used to rank facilities. Read More

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December 2018

Interferon-╬▒-induced retinopathy in chronic hepatitis C treatment: summary, considerations, and recommendations.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-╬▒ with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-╬▒ is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. Read More

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December 2018

A Brief Update on the Management of Hepatitis Delta.

Curr Gastroenterol Rep 2018 Dec 14;20(12):60. Epub 2018 Dec 14.

Loyola University Medical Center, 2160 S First Ave., Maywood, IL, 60153, USA.

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December 2018

Decreased long intergenic noncoding RNA P7 predicts unfavorable prognosis and promotes tumor proliferation via the modulation of the STAT1-MAPK pathway in hepatocellular carcinoma.

Oncotarget 2018 Nov 8;9(90):36057-36066. Epub 2017 Dec 8.

Beijing 302 Hospital, Beijing, 100039, China.

Hepatocellular carcinoma (HCC) is the most common neoplasm and is a leading cause of cancer-related death. Despite advances in the diagnosis and management of HCC, its prognosis remain unfavorable. Accumulating evidence has shown that long intergenic noncoding RNAs (lincRNAs) play central roles in the development of HCC. Read More

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November 2018

Identification of a role for serum aldo-keto reductase family 1 member B10 in early detection of hepatocellular carcinoma.

Oncol Lett 2018 Dec 3;16(6):7123-7130. Epub 2018 Oct 3.

Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China.

Despite improved screening programs, the vast majority of patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage. A lack of effective diagnosis methods for preclinical HCC has resulted in a low rate of early detection. Aldo-keto reductase family 1 member B10 (AKR1B10) is associated with several cancer types. Read More

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December 2018

Complete Recovery of Oxysterol 7╬▒-Hydroxylase Deficiency by Living Donor Transplantation in a 4-Month-Old Infant: the First Korean Case Report and Literature Review.

J Korean Med Sci 2018 Dec 22;33(51):e324. Epub 2018 Nov 22.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Oxysterol 7╬▒-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of a 3-month-old boy with progressive cholestatic hepatitis and severe hepatic fibrosis. Read More

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December 2018

Hepatitis C virus direct-acting antiviral nonadherence: Relationship to sustained virologic response and identification of at-risk patients.

J Am Pharm Assoc (2003) 2018 Dec 10. Epub 2018 Dec 10.

Objectives: There is a dearth of literature on effects of nonadherence to hepatitis C virus (HCV) direct-acting antiviral (DAA) regimens; thus, the objective of our study was to assess the impact of adherence on sustained virologic response (SVR) and evaluate factors associated with nonadherence, such as race, psychiatric comorbidities, and therapy length.

Methods: We conducted a retrospective cohort study of patients completing DAA treatment between January 2014 and May 2016 within an interdisciplinary hepatology clinic. Adherence was defined a priori as 95% or greater of DAA doses taken within the prescribed treatment period. Read More

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December 2018

Lower Optimal Treatment Adherence Among Youth Living With HIV in a Universal Health Care Setting Where ART Is Available at No Cost.

J Adolesc Health 2018 Nov 28. Epub 2018 Nov 28.

The British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Barnaby, British Columbia, Canada. Electronic address:

Purpose: We assessed differences in optimal adherence between youth (aged 15-29 years) and adults (aged Ôëą30 years) enrolled in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program from 2010 to 2016.

Methods: Population-level clinical data were used to compare optimal antiretroviral therapy adherence (Ôëą95%), based on pharmacy refill data, among youth and adults. Unadjusted and adjusted generalized estimating estimates were performed to examine the independent relationship between time-dependent age categories and optimal adherence, adjusting for confounders. Read More

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November 2018

Hepatitis B vaccination coverage among healthcare workers at a tertiary hospital in Rwanda.

BMC Res Notes 2018 Dec 13;11(1):886. Epub 2018 Dec 13.

Kigali University Teaching Hospital, Kigali, Rwanda.

Objective: We evaluated post-vaccination immunity status and describe potential risk factors associated with the lack of response among healthcare workers (HCWs) at a tertiary care hospital in Kigali, Rwanda.

Results: Of 373 HCWs, 291 (78.2%) were female and 81 (21. Read More

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December 2018

Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats.

Viruses 2018 Dec 11;10(12). Epub 2018 Dec 11.

Departamento de Gen├ętica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil.

Feline foamy virus (FFV) and feline leukemia virus (FeLV) belong to the family. While disease has not been reported for FFV infection, FeLV infection can cause anemia and immunosuppression (progressive infection). Co-infection with FFV/FeLV allows evaluation of the pathogenic potential and epidemiology of FFV infection in cats with FeLV pathology. Read More

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December 2018

Tet-Inducible Production of Infectious Zika Virus from the Full-Length cDNA Clones of African- and Asian-Lineage Strains.

Viruses 2018 Dec 9;10(12). Epub 2018 Dec 9.

Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA.

Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as an important human viral pathogen, causing congenital malformation including microcephaly among infants born to mothers infected with the virus during pregnancy. Phylogenetic analysis suggested that ZIKV can be classified into African and Asian lineages. In this study, we have developed a stable plasmid-based reverse genetic system for robust production of both ZIKV prototype African-lineage MR766 and clinical Asian-lineage FSS13025 strains using a tetracycline (Tet)-controlled gene expression vector. Read More

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December 2018