Search Our Scientific Publications & Authors

Vet Ital 2021 Dec 31;57(4):287-295. Epub 2021 Dec 31.

University Clinical Center of Serbia, Clinic for Digestive Surgery, Belgrade, Serbia.

Hepatitis E virus (HEV), the zoonotic agent of infectious hepatitis, is present in swine farms in different geographical areas. Little is known about the mechanism of liver damage and type of local immune response by HEV in swine. Therefore, the aim of this study was to determine the morphological and immunophenotypic characteristics of hepatic lesions caused by hepatitis E virus in naturally infected swine. Read More

Comp Immunol Microbiol Infect Dis 2022 May 12;86:101820. Epub 2022 May 12.

Department of Biochemistry, Izmir/Bornova Veterinary Control Institute, TR-35030 Izmir, Turkey.

Hepatitis E virus (HEV) infection as a zoonotic disease virus has been thoroughly investigated in pigs around the world, but there have been few studies in pet animals. Although molecular and serological evidence suggests that numerous other animal species may act as HEV hosts in industrialized countries, domestic pigs and wild boars are the main reservoirs of HEV genotypes 3 and 4 for human infections. In this study, the sera of 91 household cats from Türkiye were studied by using serological (new generation enzyme-linked immunosorbent assays (ELISA)) and molecular methods. Read More

World J Gastroenterol 2022 Apr;28(14):1405-1429

Department of Medicine, Section of Gastroenterology, Hepatology, and Nutrition, Center for Liver Diseases, University of Chicago, Chicago, IL 60637, United States.

Each hepatitis virus-Hepatitis A, B, C, D, E, and G-poses a distinct scenario to the patient and clinician alike. Since the discovery of each virus, extensive knowledge regarding epidemiology, virologic properties, and the natural clinical and immunologic history of acute and chronic infections has been generated. Basic discoveries about host immunologic responses to acute and chronic viral infections, combined with virologic data, has led to vaccines to prevent Hepatitis A, B, and E and highly efficacious antivirals for Hepatitis B and C. Read More

World J Hepatol 2022 Mar;14(3):482-494

Department of Medicine - Gastroenterology and Hepatology, Rutgers - New Jersey Medical School, Newark, NJ 07103, United States.

Hepatitis E virus (HEV) originally identified as a cause of acute icteric hepatitis in developing countries has grown to be a cause of zoonotic viral hepatitis in developed countries such as the United States. While there are eight identified genotypes to date, genotype 1 (HEV1), HEV2, HEV3, HEV4 are the most common to infect humans. HEV1 and HEV2 are most common in developing countries including Latina America, Africa and Asia, and are commonly transmitted through contaminated water supplies leading to regional outbreaks. Read More

World J Hepatol 2022 Mar;14(3):516-524

Department of Medicine, Ochsner Clinic Foundation, New Orleans, LA 70121, United States.

Hepatitis E virus (HEV) infections are generally self-limited. Rare cases of hepatitis E induced fulminant liver failure requiring liver transplantation are reported in the literature. Even though HEV infection is generally encountered among developing countries, a recent uptrend is reported in developed countries. Read More

J Genet Eng Biotechnol 2022 May 17;20(1):73. Epub 2022 May 17.

Clinical and Applied Genomics (CAG) Laboratory, Department of Biological Sciences, Aliah University, IIA/27, Newtown, Kolkata, 700160, India.

Background: Hepatitis E virus (HEV) is small (27-34 nm diameter) non-enveloped with positive sense ssRNA genome. Microsatellites or simple sequence repeats (SSR) are short tandem repeat sequences present across coding and non-coding regions of both prokaryotes and eukaryotes. They are involved with genome function and evolution at multiple levels. Read More

Transbound Emerg Dis 2022 May 16. Epub 2022 May 16.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, Rome, 00161, Italy.

Wild boar is the main sylvatic reservoir of the genotype 3 of hepatitis E virus (HEV). The occurrence of HEV-3 human cases has been linked to the consumption of raw or undercooked pig and wild boar meat and liver. The zoonotic transmission of HEV-3 has been confirmed by sequencing identical or strictly related viral strains in humans, wild boar, and derived food. Read More

Beni Suef Univ J Basic Appl Sci 2022 10;11(1):65. Epub 2022 May 10.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, 110025 India.

Background: Hepatitis E virus (HEV) is a member of the family and causes acute HEV infections resulting in thousands of deaths worldwide. The zoonotic nature of HEV in addition to its tendency from human to human transmission has led scientists across the globe to work on its different aspects. HEV also accounts for about 30% mortality rates in case of pregnant women. Read More

Cureus 2022 Apr 12;14(4):e24056. Epub 2022 Apr 12.

Pediatrics, Nishtar Medical University, Multan, PAK.

Objective: Acute viral hepatitis (AVH) in children is a serious and major public health concern globally and in developing countries such as Pakistan. We conducted this study to determine the clinical and epidemiological spectrum of AVH due to hepatitis A virus (HAV) and hepatitis E virus (HEV) infection in children.

Methodology: This cross-sectional study was conducted at the Pediatric Medicine Department of a tertiary care hospital from February 20, 2020, to February 20, 2022. Read More

Animals (Basel) 2022 Apr 20;12(9). Epub 2022 Apr 20.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.

Genotype 3 of hepatitis E virus (HEV-3) is the most common in Europe in both humans and pigs. HEV-3 strains are zoonotic, and foodborne cases associated with consumption of raw and undercooked pork products, mainly liver sausages, have been described. HEV-3 circulates largely in European pig farms, maybe due to its long persistence in the environment. Read More

Travel Med Infect Dis 2022 May 10;48:102355. Epub 2022 May 10.

Instituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad nacional de Córdoba, Enfermera Gordillo Gómes s/n, CP: 5016, Córdoba, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2290, C1425FQB, Ciudad Autónoma de Buenos Aires, Argentina; Fundación Banco Central de Sangre, Caseros 1576, CP: 5000, Córdoba, Argentina.

Background: The hepatitis E virus (HEV) causes acute hepatitis, which can progress to chronicity in immunosuppressed patients. It is transmitted mainly by the fecal-oral or zoonotic routes, but there is current evidence that it can be transmitted by blood transfusions. The objective of the study was to investigate HEV infections in blood donors in Argentina, within the framework of a hemovigilance program. Read More

Front Vet Sci 2022 26;9:874030. Epub 2022 Apr 26.

Grupo Sanidad y Biotecnología, Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain.

An experimental infection approach was used to estimate the competence of the common mosquito, , for hepatitis E virus replication and transmission, using an isolate of hepatitis E virus genotype 3 of human origin in varying infectious doses. The experimental approach was carried out in biosafety level 2 conditions on three batches of 120 females, each using an artificial feeding system containing the virus in aliquots of fresh avian blood. Mosquitoes from each batch were collected 1, 7, 14, and 21 days post-infection (dpi) and dissected. Read More

Bioinformation 2021 30;17(9):818-828. Epub 2021 Sep 30.

Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.

Hepatitis E virus (HEV) is the main cause of acute hepatitis worldwide. HEV accounts for up to 30% mortality rate in pregnant women, with highest incidences reported for genotype 1 (G1) HEV. The contributing factors in adverse cases during pregnancy in women due to HEV infection is still debated. Read More

J Antimicrob Chemother 2022 May 10. Epub 2022 May 10.

Infinity, Université Toulouse, CNRS, Inserm, UPS, Toulouse, France.

Transbound Emerg Dis 2022 May 5. Epub 2022 May 5.

Institutes of Biomedical Sciences, Shanxi University, Taiyuan, China.

Zoonotic hepatitis E, mainly caused by swine hepatitis E virus (sHEV), is endemic in China, causing great economic disruption and public health threats. Although recombination is critical for the evolution of viruses, there is a limited assessment of its occurrence among sHEVs. Herein, we analysed all available sHEV full-length genomes isolated in China during the past two decades (40 isolates) compared to 72 other sHEV strains isolated in different countries and determined that sHEV genotype 4 (sHEV4) dominates China. Read More

Clin J Gastroenterol 2022 May 4. Epub 2022 May 4.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

A case of subclinical hepatitis E virus (HEV) infection was detected by nucleic acid amplification test on blood donation. The patient was followed-up until day 220 after the blood donation but showed no symptoms throughout the observation period. Aspartate aminotransferase and alanine aminotransferase levels reached the maximum values on day 37 with a slight increase but remained in normal ranges from day 67 to 220. Read More

Rev Chilena Infectol 2021 10;38(5):716-719

Departamento de Medicina Interna, Hospital Clínico, Universidad de Chile, Santiago, Chile.

The determination of anti-hepatitis E virus antibodies (anti-HEV) has a high variability depending on the assay used. In 2015, with a manual ELISA method, we reported anti-HEV IgG seroprevalence of 32.6% in patients under hepatitis study. Read More

CMAJ 2022 May;194(17):E616

J Viral Hepat 2022 May 2. Epub 2022 May 2.

Octapharma AB, Stockholm, Sweden.

Hepatitis E virus (HEV) is endemic in Europe. However, standardized methods for the surveillance of HEV viremia in the general population are lacking. This study aimed to compare the incidence of HEV among blood donors in two European countries, Germany and Portugal, during the period 2015-2018. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2022 Apr;56(4):464-467

Xiamen Zhong Shan Hospital, Xiamen University, Xiamen 361004, China.

To evaluate the safety and immunogenicity of hepatitis E vaccine(HEV)in Maintenance hemodialysis(MHD)patients. Based on an open-labeled controlled trial, from May 2016 to March 2018, 35 eligible MHD patients were recruited in the Hemodialysis Center of Zhongshan Hospital Affiliated to Xiamen University as the experimental group, and 70 MHD patients with matched age, gender and underlying diseases as the control group. The experimental group received HEV at 0, 1 and 6 months according to the standard vaccination procedures, while the control group received routine diagnosis and treatment without vaccine and placebo injection to observe the safety and immunogenicity of the vaccine. Read More

Sci Rep 2022 Apr 29;12(1):7005. Epub 2022 Apr 29.

Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.

Camels gained attention since the discovery of MERS-CoV as intermediary hosts for potentially epidemic zoonotic viruses. DcHEV is a novel zoonotic pathogen associated with camel contact. This study aimed to genetically characterize DcHEV in domestic and imported camels in Saudi Arabia. Read More

J Hepatol 2022 Apr 26. Epub 2022 Apr 26.

Charité-Universitätsmedizin Berlin, Berlin, Germany; German Center for Infection Research, Berlin, Germany.

Braz J Infect Dis 2022 Mar-Apr;26(2):102350. Epub 2022 Apr 26.

Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brasil; Fundação Oswaldo Cruz - Mato Grosso do Sul (FIOCRUZ-MS), Campo Grande, MS, Brasil.

A cross-sectional study was carried out in the Hematology and Hemotherapy Institute of the state of Mato Grosso do Sul (Hemosul) to evaluate the seroprevalence and risk factors of Hepatitis E Virus (HEV) exposure among volunteer blood donors in Central Brazil. Two-hundred fifty samples from the biorepository were tested for anti-HEV IgG and IgM using the Wantai HEV ELISA test. The seroprevalence of HEV exposure was 6. Read More

Can Commun Dis Rep 2022 Apr 6;48(4):124-130. Epub 2022 Apr 6.

Héma-Québec, Montréal, QC.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic galvanized blood donor seroprevalence studies, which continue to inform public health policy. We propose that the two Canadian blood suppliers, Héma-Québec and Canadian Blood Services, expand their role in public health surveillance in the post-pandemic period. Together blood suppliers have near-national reach, collecting blood donations nearly every day in all larger cities and many smaller municipalities. Read More

Rev Saude Publica 2022 22;56:29. Epub 2022 Apr 22.

Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia, GO, Brasil.

Objective: To estimate the prevalence of hepatitis A virus (HAV) and hepatitis E virus (HEV) among immigrants and refugees in Goiás, Central Brazil.

Methods: Overall, 355 individuals were interviewed, and blood samples were tested for anti-HAV and anti-HEV IgG. Anti-HEV-positive samples were similarly tested for HEV RNA. Read More

Med J Armed Forces India 2022 Apr 26;78(2):185-191. Epub 2021 Feb 26.

Director, Manipal Institute of Virology, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India.

Background: This study was carried out to understand the circulating genotypes of Hepatitis A virus (HAV) in South West, East and North East India during the period 2017-2018 as a part of acute febrile illness surveillance at the Manipal Institute of Virology.

Methods: Archived serum samples of 48 Hepatitis A confirmed cases were subjected to RNA extraction using QIAamp® Viral RNA Mini Kit (QIAGEN, Germany). The samples with molecular confirmation for HAV by reverse transcriptase real-Time PCR (Real Star® HAV RT-PCR Kit 2. Read More

Viruses 2022 Mar 31;14(4). Epub 2022 Mar 31.

National Consultant Laboratory for HAV and HEV, Institute of Clinical Microbiology and Hygiene, University Medical Center Regensburg, 93053 Regensburg, Germany.

, also known as rat hepatitis E virus (HEV), has been shown to sporadically cause disease in immunocompromised and immunocompetent adults. While routine serological assays vary in reactivity, rat HEV is not detected in routine HEV RT-PCR. Thus, such infections could be either missed or misclassified as conventional HEV () infections. Read More

Emerg Infect Dis 2022 May;28(5):1074-1076

Hepatitis E virus is a common cause of acute viral hepatitis. We analyzed reports of hepatitis E outbreaks among forcibly displaced populations in sub-Saharan Africa during 2010-2020. Twelve independent outbreaks occurred, and >30,000 cases were reported. Read More

Infect Genet Evol 2022 Apr 18;101:105284. Epub 2022 Apr 18.

Department of Epidemiology, Ministry of Education Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:

There has been an increase in the reported number of animals worldwide that carry the hepatitis E virus (HEV). This study aimed to explore potential animal hosts for HEV through codon usage analysis. Full-length HEV sequences of six genotypes as well as codon usage of potential animal hosts were collected. Read More

Am J Case Rep 2022 Apr 19;23:e936148. Epub 2022 Apr 19.

Medical Clinic III, Department of Nephrology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

BACKGROUND Varices of the upper gastrointestinal tract are due to portal hypertension and can result from occlusion of the portal venous system. This report is of a 55-year-old man with recurrent gastrointestinal bleeding due to stricture of the portal vein anastomotic site to inferior vena cava (IVC) 12 years after combined pancreas and kidney transplantation. CASE REPORT A 55-year-old man presented bleeding episodes requiring transfusion of more than 70 units of red blood cells (RBCs), complicated by bacterial and viral infection episodes including cytomegalovirus (CMV) reactivation and hepatitis E and transient impairment of function of the renal allograft. Read More