5,042 results match your criteria Hepatitis E


A guide to the management of hepatitis E infection during pregnancy.

Expert Rev Gastroenterol Hepatol 2019 Mar 24;13(3):205-211. Epub 2019 Jan 24.

a Department of Gastroenterology and Hepatology , Max Super Speciality Hospital , Ghaziabad , India.

Introduction: Hepatitis E virus (HEV) infection has distinct features, depending upon the genotype and geographical area. HEV genotypes 1 and 2 are endemic to various developing countries causing epidemics of acute viral hepatitis with human to human transmission. On the other hand, HEV genotypes 3 and 4 prevalent in developed countries commonly lead to subclinical infection and are transmitted zoonotically. Read More

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http://dx.doi.org/10.1080/17474124.2019.1568869DOI Listing

Human Seroprevalence to 11 Zoonotic Pathogens in the U.S. Arctic, Alaska.

Vector Borne Zoonotic Dis 2019 Feb 21. Epub 2019 Feb 21.

1 Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska.

Background: Due to their close relationship with the environment, Alaskans are at risk for zoonotic pathogen infection. One way to assess a population's disease burden is to determine the seroprevalence of pathogens of interest. The objective of this study was to determine the seroprevalence of 11 zoonotic pathogens in people living in Alaska. Read More

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http://dx.doi.org/10.1089/vbz.2018.2390DOI Listing
February 2019

Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018.

Emerg Infect Dis 2019 Mar;25(3):425-433

Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. Read More

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http://dx.doi.org/10.3201/eid2503.181563DOI Listing

Hepatitis E virus strains infecting Swedish domestic pigs are unique for each pig farm and remain in the farm for at least two years.

Transbound Emerg Dis 2019 Feb 19. Epub 2019 Feb 19.

Dep. of Infectious Diseases, Inst. of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

Hepatitis E virus (HEV) genotype 3 (HEV3) is distributed globally and infects both humans and animals, mainly domestic pigs and wild boars, which are the major reservoirs. In this study, the prevalence of HEV among Swedish pigs was investigated by HEV RNA analysis in 363 fecal samples from 3-month old piglets sampled twice (2013 and 2014) in 30 Swedish pig farms. Four different types of farms were investigated; organic, conventional closed (keeping the sow), satellites in a sow pool (conventional farms sharing sows), and conventional non-closed farms (purchasing gilts). Read More

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http://doi.wiley.com/10.1111/tbed.13153
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http://dx.doi.org/10.1111/tbed.13153DOI Listing
February 2019
1 Read

[Hepatitis E - an underestimated infectious disease].

Authors:
Helmut Diepolder

MMW Fortschr Med 2019 Feb;161(3):61-63

Kliniken Ostallgäu-Kaufbeuren, Klinikum Kaufbeuren, Dr.-Gutermann-Straße 2, D-87600, Kaufbeuren, Deutschland.

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http://dx.doi.org/10.1007/s15006-019-0188-2DOI Listing
February 2019

Frequency of Hepatotropic Viruses Leading To Deranged Liver Function Tests in Renal Transplant Recipients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):202-206

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

Objectives: The preferred modality for renal replacement therapy is renal transplantation. Marked improvements in early graft survival and long-term graft function have made renal transplantation a more cost-effective alternative to dialysis. The presence of liver disease in the posttransplant period adversely affects graft function and survival. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P66DOI Listing
January 2019

Beware of HCV and HEV in Patients with Suspected Drug-Induced Liver Injury.

Curr Hepatol Rep 2018 Sep 11;17(3):270-275. Epub 2018 Jul 11.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Purpose Of Review-: Without a specific biomarker the diagnosis of drug-induced liver injury (DILI) relies on exclusion of other causes of liver injury. This review examines the importance of testing for hepatitis C (HCV) and hepatitis E (HEV) in patients with suspected DILI.

Recent Findings-: Several national DILI registries have reported HCV and HEV infection in patients initially diagnosed with DILI. Read More

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http://dx.doi.org/10.1007/s11901-018-0410-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369516PMC
September 2018
1 Read

Hepatitis B virus Surface gene mutants in immunoprophylaxis-failed infants from Southern China.

J Med Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatitis B virus (HBV) vaccination was considered the most powerful tool for preventation of HBV transmission from mother to infant. In 1992 a universal HBV vaccination program for infants was lauched in China. The aim of this study was to investigate the HBV Surface antigen (HBsAg) varations in immunoprophylaxis-failed infants, vaccine free infant patients and adult chronic hepatitis B(CHB) patients (without nucleoside analog treatment). Read More

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http://dx.doi.org/10.1002/jmv.25430DOI Listing
February 2019
1 Read
2.347 Impact Factor

Hepatitis E virus infection and its associated adverse feto-maternal outcomes among pregnant women in Qinhuangdao, China.

J Matern Fetal Neonatal Med 2019 Feb 13:1-111. Epub 2019 Feb 13.

a Department of Microbiology and Center of Infectious Disease , School of Basic Medical Sciences , Peking University Health Science Center , Beijing , China.

Background & Aims: The aim of this study was to investigate the positive rate of hepatitis E virus (HEV) infection and the possible adverse outcomes in pregnant women of Qinhuangdao, China.

Methods: Serum samples of 946 pregnant women were collected from July 2017 to October 2017 in Qinhuangdao First Hospital. All samples were tested for anti-HEV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). Read More

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https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
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http://dx.doi.org/10.1080/14767058.2019.1582630DOI Listing
February 2019
2 Reads

[Acute decompensation (AD) of advanced chronic liver disease (ACLD) and hepatitis E virus (HEV) infection as the trigger].

Klin Mikrobiol Infekc Lek 2018 Sep;24(3):82-87

Division Hepatology, gastroenterology and liver transplantation of Department Internal medicine II, Faculty of Medicine, Slovak Medical University, FD Roosevelt Hospital, Banska Bystrica; Slovakia, e-mail:

Introduction: HEV infection is perceived as the cause of acute hepatitis in endemic areas. In addition, it may also manifest as a possible trigger of AD or acute-on-chronic liver failure (ACLF).

Objectives: To determine the prevalence of HEV infection as a trigger of AD/ACLF in patients admitted for decompensated ACLD (dACLD). Read More

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September 2018
2 Reads

A case-control study into risk factors for acute hepatitis E in the Netherlands, 2015-2017.

J Infect 2019 Feb 7. Epub 2019 Feb 7.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address:

Objectives: A case-control study was performed (2015-2017) to identify risk factors for acute hepatitis E in the Netherlands.

Methods: A questionnaire on potential sources of hepatitis E virus (HEV) exposure, health and socio-demographics was completed by 376 patients with acute hepatitis E, and 1534 controls matched for age, gender and region of residence.

Results: Traditional Dutch dry raw sausages of pork muscle meat, called "cervelaat", "snijworst", and "boerenmetworst" were reported by 72% of the patients, and 46% of controls (aOR 3. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.001DOI Listing
February 2019
1 Read

Serological evidence of hepatitis E virus and influenza A virus infection in farmed wild boars in China.

Acta Trop 2019 Feb 6;192:87-90. Epub 2019 Feb 6.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, People's Republic of China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province 130118, People's Republic of China; Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu Province 225009, People's Republic of China. Electronic address:

Hepatitis E virus (HEV) and influenza A virus (IAV) are two important pathogens which can infect humans and various animals causing public health problems. In this study, the seroprevalence and risk factors associated with HEV and IAV infection in farmed wild boars were investigated in China. A total of 758 serum samples were collected from farmed wild boars between 2015 and 2016, and antibodies against HEV and IAV were examined by enzyme-linked immunosorbent assay (ELISA) using commercially available kits. Read More

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http://dx.doi.org/10.1016/j.actatropica.2019.02.004DOI Listing
February 2019
1 Read

Reply (to LTE HEP-19-0019.

Authors:
Mary Drinane

Hepatology 2019 Feb 8. Epub 2019 Feb 8.

Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, New Hampshire, US.

The letter by Kamar et al., advancements in our understanding of chronic hepatitis E infection in solid organ transplant patients over time are highlighted. They cite the 2019 publication on the importance of fecal hepatitis E PCR in determining clearance of chronic infection. Read More

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http://dx.doi.org/10.1002/hep.30545DOI Listing
February 2019
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Liver-specific Gene Delivery Using Engineered Virus-Like Particles of Hepatitis E Virus.

Sci Rep 2019 Feb 7;9(1):1616. Epub 2019 Feb 7.

The Catholic University Liver Research Center & WHO Collaborating Center of Viral Hepatitis, Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Virus-like particles (VLPs) possess great potential for organ-specific transport of therapeutic agents due to their central cavity surrounded by viral capsid proteins and similar tropism to their original viruses. The N-terminal truncated second open reading frame (Nt-ORF2) of the hepatotropic hepatitis E virus (HEV) forms VLPs via self-assembly. In the present study, we investigated whether HEV-LPs could deliver foreign genes specifically to the liver. Read More

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http://www.nature.com/articles/s41598-019-38533-7
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http://dx.doi.org/10.1038/s41598-019-38533-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367430PMC
February 2019
4 Reads
5.078 Impact Factor

No clear evidence for an effect of sofosbuvir against hepatitis E virus in organ-transplant-patients.

Hepatology 2019 Feb 5. Epub 2019 Feb 5.

Biomedical Research Center, Northwest Minzu University, Lanzhou, China.

Recently, Drinane et al. presented the case of a kidney-pancreas transplant patient with chronic hepatitis E virus (HEV) infection who failed to clear HEV after two courses of ribavirin, and who thereafter eradicated HEV when ribavirin was combined to sofosbuvir. The authors claimed that sofosbuvir has a therapeutic activity against HEV. Read More

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http://dx.doi.org/10.1002/hep.30546DOI Listing
February 2019
2 Reads

[Classical and extrahepatic presentation of acute hepatitis E infection].

Ugeskr Laeger 2019 Jan;181(4)

In this case report, we present two Danish patients with hepatitis E virus (HEV) infection. In both cases, the route of transmission remained unclear. The infection led to typical symptoms in one case, whereas the other patient experienced neurological symptoms. Read More

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January 2019
2 Reads

Acute HEV hepatitis: clinical and laboratory diagnosis.

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):764-770

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Objective: Hepatitis E Virus (HEV) is probably the most common cause of acute hepatitis worldwide. It has been regarded for a long time as a disease limited to developing countries. Recently, the refinement of diagnostic techniques, on the one hand, and migratory flows, on the other hand, have also led to the identification of an increased number of HEV infections in industrialized countries. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16891DOI Listing
January 2019
1 Read

Prevalence of hepatitis E infection in HIV/HCV-coinfected patients in Spain (2012-2014).

Sci Rep 2019 Feb 4;9(1):1143. Epub 2019 Feb 4.

Laboratorio de Referencia e Investigación en Hepatitis Víricas, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. Read More

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http://dx.doi.org/10.1038/s41598-018-37328-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361883PMC
February 2019
2 Reads

Acute sporadic hepatitis E in the Zhejiang coastal area of China: a 14-year hospital-based surveillance study.

Virol J 2019 Feb 4;16(1):16. Epub 2019 Feb 4.

Department of Infectious Diseases, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou, (310051), Zhejiang Province, China.

Background: To examine the epidemiological trends and changes of hepatitis E virus (HEV) infection and the potential risk factors for severe infection in the Zhejiang eastern coastal area of China.

Methods: We analyzed statutory hepatitis E cases notifications and inpatient data held by the national surveillance and hospital information systems in Wenzhou, Taizhou, Ningbo, and Zhoushan cities of the Zhejiang eastern coastal area of China.

Results: Nine thousand four hundred sixteen hepatitis E cases were reported from 2004 to 2017, with an average incidence of 2. Read More

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http://dx.doi.org/10.1186/s12985-019-1119-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360671PMC
February 2019
2 Reads
2.181 Impact Factor

Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan.

Libyan J Med 2019 Dec;14(1):1564511

c College of Medicine , Princess Nourah bint Abdulrahman University , Riyadh , Saudi Arabia.

Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366427PMC
December 2019
1 Read

Immunogenicity and safety of an accelerated hepatitis E vaccination schedule in healthy adults: a randomized, controlled, open-label, phase IV trial.

Clin Microbiol Infect 2019 Jan 31. Epub 2019 Jan 31.

Institute of Immunization and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China; Xiamen INNOVAX Biotech CO.Ltd, Xiamen, China; Institute of Immunization and Prevention, Changshan Center for Disease Control and Prevention, Quzhou, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, Fujian, China. Electronic address:

Objectives: This study aimed to evaluate the immunogenicity and safety of a hepatitis E vaccine using an accelerated vaccination schedule (vaccine doses at 0, 7, and 21 days).

Methods: A total of 126 participants aged≥18 were randomly assigned to receive the HEV vaccine in either the accelerated group (0, 7 and 21 days) or the routine group (0, 1 and 6 months). Serology samples were obtained at 0, 21, 28, and 51 days and 7 months in the accelerated group or 0, 1, 2 and 7 months in the routine group after the first vaccine injection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.015DOI Listing
January 2019

Correction to: Prevalence and phylogenetic analysis of hepatitis E virus in pigs, wild boars, roe deer, red deer and moose in Lithuania.

Acta Vet Scand 2019 01 31;61(1). Epub 2019 Jan 31.

Department of Anatomy and Physiology, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Tilzes str. 18, Kaunas, Lithuania.

Following publication of the original article [1], we have been notified of a typing error in the "Discussion" section. Read More

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http://dx.doi.org/10.1186/s13028-019-0443-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354410PMC
January 2019

Hepatitis E virus polymerase binds to IFIT1 to protect the viral RNA from IFIT1-mediated translation inhibition.

J Gen Virol 2019 Jan 31. Epub 2019 Jan 31.

2​Savitribai Phule Pune University, Ganeshkhind, Pune 411 007, India.

Hepatitis E virus (HEV) induces interferons and regulates the induction of interferon-stimulated genes (ISGs) in the host cell. HEV infection has been shown to promote the expression of different ISGs, such as ISG15, IFIT1, MX1, RSAD2/Viperin and CxCL10, in cell culture and animal models. Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) is an ISG-encoded protein that inhibits the translation of viral RNA, having 5'-triphosphate or the mRNA lacking 2'-O-methylation on the 5'cap. Read More

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http://www.microbiologyresearch.org/content/journal/jgv/10.1
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http://dx.doi.org/10.1099/jgv.0.001229DOI Listing
January 2019
3 Reads

Probable transmission of hepatitis E virus (HEV) via transfusion in the United States.

Transfusion 2019 Jan 31. Epub 2019 Jan 31.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Background: Hepatitis E virus (HEV) can inapparently infect blood donors. To assess transfusion transmission of HEV in the United States, which has not been documented, a donor-recipient repository was evaluated.

Study Design And Methods: To identify donations that contained HEV RNA and were linked to patient-recipients with antibody evidence of HEV exposure, we assayed samples from the Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient repository that represents 13,201 linked donations and 3384 transfused patients. Read More

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http://doi.wiley.com/10.1111/trf.15140
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http://dx.doi.org/10.1111/trf.15140DOI Listing
January 2019
8 Reads

Superinfection of hepatitis E as a factor in the development of acute hepatic encephalopathy on the background of HBV-cirrhosis of the liver.

Ter Arkh 2018 Feb;90(2):102-104

Kirov Infectious Clinical Hospital, Kirov, Russia.

The article presents an analysis of the clinical case of superinfection of autochthonous acute hepatitis E against the background of HBV-cirrhosis of the liver. HEV infection was diagnosed in a 39 year old man who did not travel outside the region and the country for a long time and used unboiled water. The peculiarity of the disease in the non-endemic region was: a severe course of hepatitis E against the background of HBV etiology, with the development of the clinic for acute hepatic insufficiency and encephalopathy, the presence of severe cytolysis syndrome, cholestasis, hepatic-cell insufficiency and prolonged convalescence. Read More

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http://dx.doi.org/10.26442/terarkh2018902102-104DOI Listing
February 2018
2 Reads

Near-Complete Genome Sequence of a Human Pegivirus Variant Isolated from a Hepatitis E Virus-Infected Patient.

Microbiol Resour Announc 2019 Jan 24;8(4). Epub 2019 Jan 24.

Clinical Laboratory Center, Taizhou People's Hospital, Taizhou, Jiangsu, China.

Using viral metagenomics, we analyzed the virome of a blood sample from a hepatitis E patient. We identified viral sequences showing significant similarity to human pegivirus (HPgV), anellovirus, and hepatitis E virus. The near-complete genome of a genotype 3 HPgV strain was acquired and characterized. Read More

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http://dx.doi.org/10.1128/MRA.01151-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346178PMC
January 2019
1 Read

Transmission of A Novel Genotype Hepatitis E Virus from Bactrian Camels to Cynomolgus Macaques.

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

Hepatitis E virus (HEV) is zoonotic and a major cause of acute viral hepatitis worldwide. Recently, we identified a novel HEV genotype 8 (HEV8) in Bactrian camels in Xinjiang, China. However, the epidemiology, pathogenicity and zoonotic potential of HEV8 are unclear. Read More

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http://dx.doi.org/10.1128/JVI.02014-18DOI Listing
January 2019
2 Reads

[The duration of preservation of anamnestic antibodies to hepatitis E virus.]

Klin Lab Diagn 2018 ;63(5):310-314

The Federal State Budget Educational Institution of Higher Education "I.I. Mechnikov North-Western State Medical University" of Minzdrav of Russia, 191015, St. Petersburg, Russia.

The purpose of the study was to determine the duration of antibody response against hepatitis E virus (anti-HEV). Veterans of the war in Afghanistan who were in this endemic region in the late 1970s and early 1980s were tested for anti-HEV. On average, 20 years after the end of military service in Afghanistan, the rate of seropositivity was 30. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-5-310-314DOI Listing
January 2018

Safe supplies: few infections in UK blood and tissue donors.

Transfus Med 2019 Jan 28. Epub 2019 Jan 28.

NHS Blood and Transplant/Public Health England Epidemiology Unit, NHS Blood and Transplant, London, UK.

Aims/objectives: Here, we describe the annual review of the UK blood services' infection surveillance schemes for 2017 (www.gov.uk/government/publications/safe-supplies-annual-review). Read More

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http://doi.wiley.com/10.1111/tme.12576
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http://dx.doi.org/10.1111/tme.12576DOI Listing
January 2019
3 Reads

[Detection of HEV RNA amounts and genotypes in raw milks obtained from different animals].

Mikrobiyol Bul 2019 Jan;53(1):43-52

Harran University Veterinary of Veterinary Medicine, Department of Food Hygiene and Technology, Şanlıurfa, Turkey.

Hepatitis E virus (HEV) is one of the major foodborne viral pathogens transmitted through the fecal-oral route. Four genotypes of HEV are known to infect humans and it is reported that different types of HEV are active in zoonotic transitions. It is known that the HEV genotype 1 and HEV genotype 2 infections are generally acute and the HEV genotype 3 infections are chronic. Read More

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http://dx.doi.org/10.5578/mb.67468DOI Listing
January 2019
1 Read

Meta-Analysis of Human IgG anti-HEV Seroprevalence in Industrialized Countries and a Review of Literature.

Viruses 2019 Jan 20;11(1). Epub 2019 Jan 20.

Unité des Virus Emergents (UVE), Aix-Marseille Université, IRD 190, INSERM 1207, IHU Méditerranée Infection, 13005 Marseille, France.

Although Hepatitis E is increasingly described as a major cause of liver disease in industrialized countries, the epidemiology is far from being fully elucidated. We provide here a comprehensive review of documented clusters of cases, and of serological studies conducted in populations with distinct types of exposure. Seroprevalence rates range from <5% to >50% depending on the countries and the groups of population. Read More

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http://dx.doi.org/10.3390/v11010084DOI Listing
January 2019

Failure to respond to ribavirin despite elevated intra-erythrocyte zinc level in transplant-patients with chronic hepatitis E virus infection.

Transpl Infect Dis 2019 Jan 21:e13050. Epub 2019 Jan 21.

Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.

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http://dx.doi.org/10.1111/tid.13050DOI Listing
January 2019
3 Reads

High seroprevalence of hepatitis E virus in rabbit slaughterhouse workers.

Transbound Emerg Dis 2019 Jan 19. Epub 2019 Jan 19.

Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China.

Hepatitis E virus (HEV) was first detected in rabbits in the year 2009. Rabbit HEV is now known to be widely prevalent in rabbits and tentatively assigned into genotype 3 (HEV-3) as subgenotype-3ra (HEV-3ra). However, its role in human infection remains undetermined. Read More

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http://dx.doi.org/10.1111/tbed.13130DOI Listing
January 2019
2 Reads

Hepatitis E virus in Spanish donors and the necessity for screening.

J Viral Hepat 2019 Jan 19. Epub 2019 Jan 19.

Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.

Hepatitis E virus (HEV) represents a major health problem worldwide. As the course of HEV cases is often subclinical, asymptomatic infections could represent an important source of viral spread and infection via routes such as blood donations. Before universal screening for HEV in blood donations can be implemented, studies evaluating the incidence of infection are needed to establish the potential risk of viral transmission. Read More

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http://dx.doi.org/10.1111/jvh.13064DOI Listing
January 2019
4 Reads

Hepatitis E virus genotype 3 and capsid protein in the blood and urine of immunocompromised patients.

J Infect 2019 Jan 17. Epub 2019 Jan 17.

Inserm UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France; Université Paul Sabatier, Toulouse, France. Electronic address:

Objectives: Hepatitis E virus genotype 3 (HEV3) is responsible for acute and chronic liver disease in solid organ transplant (SOT) recipients. HEV was recently found in the urine of some acutely and chronically genotype 4-infected patients.

Methods: We examined the urinary excretion of HEV3 by 24 consecutive SOT recipients at the acute phase of HEV hepatitis and characterized the excreted virus. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.01.004DOI Listing
January 2019
2 Reads

Performance characteristics of the VIDAS® ANTI-HEV IgM and IgG assays.

J Clin Virol 2019 Jan 11;112:10-14. Epub 2019 Jan 11.

CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, National Reference Center for Hepatitis E, F-31300, France; INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F-31300, France.

Background: Several unautomated anti-HEV diagnostic tests are presently available.

Objective: We have evaluated the performance of the new automated VIDAS® ANTI-HEV IgM and IgG assays.

Study Design: We assessed the reproducibility and cross-reactivity of both VIDAS assays and the analytical sensitivity and linearity of the VIDAS IgG assay. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.01.005DOI Listing
January 2019
2 Reads

Cell culture systems for the study of hepatitis E virus.

Antiviral Res 2019 Mar 14;163:34-49. Epub 2019 Jan 14.

Ruhr-University Bochum, Faculty of Medicine, Department of Molecular and Medical Virology, Bochum, Germany. Electronic address:

Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically-transmitted viral hepatitis worldwide. Increasing numbers of HEV infections, together with no available specific anti-HEV treatment, contributes to the pathogen's major health burden. A robust cell culture system is required for virologic studies and the development of new antiviral drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01663542183072
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http://dx.doi.org/10.1016/j.antiviral.2019.01.007DOI Listing
March 2019
10 Reads

An Optimized High-Throughput Neutralization Assay for Hepatitis E Virus (HEV) Involving Detection of Secreted Porf2.

Viruses 2019 Jan 15;11(1). Epub 2019 Jan 15.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China.

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. Current methods for evaluating the neutralizing activity of HEV-specific antibodies include immunofluorescence focus assays (IFAs) and real-time PCR, which are insensitive and operationally complicated. Here, we developed a high-throughput neutralization assay by measuring secreted pORF2 levels using an HEV antigen enzyme-linked immunosorbent assay (ELISA) kit based on the highly replicating HEV genotype (gt) 3 strain Kernow. Read More

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http://www.mdpi.com/1999-4915/11/1/64
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http://dx.doi.org/10.3390/v11010064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356577PMC
January 2019
6 Reads

Treatment of hypercholesterolaemia with PCSK9 inhibitors in patients after cardiac transplantation.

PLoS One 2019 16;14(1):e0210373. Epub 2019 Jan 16.

Department of Cardiac Surgery, University of Leipzig-Leipzig Heart Center, Leipzig, Germany.

Background: Hypercholesterolaemia is common in patients after cardiac transplantation. Monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) reduce low-density lipoprotein (LDL) cholesterol levels and subsequently the risk of cardiovascular events in patients with dyslipidaemia. There are no published data on the effect of this medication class on cholesterol levels in patients after cardiac transplantation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210373PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335020PMC
January 2019
1 Read

Rat hepatitis E virus linked to severe acute hepatitis in an immunocompetent patient.

J Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

Department of Medicine, Nova Scotia Health Authority, Canada.

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan and the United States with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat hepatitis E virus with a considerably divergent genomic sequence compared to other rat HEV strains. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz025DOI Listing
January 2019
16 Reads

Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis.

Infect Dis Poverty 2019 Jan 16;8(1). Epub 2019 Jan 16.

School of Medicine, USP, São Paulo, SP, Brazil.

Background: Hepatitis E virus (HEV) is a member of the Hepeviridae family; it has four main genotypes and one serotype. While genotypes 1 and 2 cause epidemic hepatitis and are transmitted via water and the fecal-oral route, genotypes 3 and 4 are zoonotic. In the various seroprevalence studies of hepatitis E in Brazil, the numbers reported vary widely and are difficult to interpret. Read More

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http://dx.doi.org/10.1186/s40249-018-0514-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334402PMC
January 2019
7 Reads

Experimental infection of rabbit with swine-derived hepatitis E virus genotype 4.

Vet Microbiol 2019 Feb 4;229:168-175. Epub 2019 Jan 4.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China. Electronic address:

Hepatitis E virus (HEV) is a zoonotic virus that is capable of causing cross-species infection. Rabbits can be experimentally infected with human- and swine-derived HEV-4 in the species Orthohepevirus A, and avian-derived HEV-3 in the species Orthohepevirus B suggesting rabbits can serve as an animal model for zoonotic HEV infection study. However, these studies show that the infectivity of swine HEV isolates in rabbits is not consistent. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781135183116
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http://dx.doi.org/10.1016/j.vetmic.2019.01.001DOI Listing
February 2019
9 Reads
2.511 Impact Factor

Molecular characterization of human enteric viruses in food, water samples, and surface swabs in Sicily.

Int J Infect Dis 2019 Jan 9;80:66-72. Epub 2019 Jan 9.

Istituto Zooprofilattico Sperimentale della Sicilia, Palermo, Italy.

Objectives: Enteric viruses are responsible for foodborne and waterborne infections affecting a large number of people. Data on food and water viral contamination in the south of Italy (Sicily) are scarce and fragmentary. The aim of this study was to evaluate the presence of viral contamination in food, water samples, and surface swabs collected in Sicily METHODS: The survey was conducted on 108 shellfish, 23 water samples (seawater, pipe water, and torrent water), 52 vegetables, one peach and 17 berries, 11 gastronomic preparations containing fish products and/or raw vegetables, and 28 surface swabs. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.12.011DOI Listing
January 2019
3 Reads

Complete Genome Sequence of a Hepatitis E Virus Genotype 1e Strain from an Outbreak in Nigeria, 2017.

Microbiol Resour Announc 2019 Jan 3;8(1). Epub 2019 Jan 3.

Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany.

Hepatitis E virus genotype 1 (HEV-1) is associated with large epidemics. Notably, HEV subtype 1e (HEV-1e) has caused HEV outbreaks in sub-Saharan Africa. We report here the second full-length genome sequence of an HEV-1e strain (NG/17-0503) from a recent outbreak in Nigeria in 2017. Read More

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http://dx.doi.org/10.1128/MRA.01378-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318360PMC
January 2019
4 Reads

HEV ORF3 downregulatesCD14 and CD64 to impair macrophages phagocytosis through inhibiting JAK/STAT pathway.

J Med Virol 2019 Jan 13. Epub 2019 Jan 13.

Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases, Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatitis E virus (HEV) could induce chronic hepatitis and liver failure with high mortality through unknown mechanisms. The previous study showed that the HEV open reading frames 3 (ORF3) could inhibit macrophages inflammatory response. Impaired macrophages phagocytosis was also found in patients infected with HEV and its nucleic acids could be detected in macrophages. Read More

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http://doi.wiley.com/10.1002/jmv.25400
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http://dx.doi.org/10.1002/jmv.25400DOI Listing
January 2019
8 Reads

Clinical features and determinants of chronicity in hepatitis E virus infection.

J Viral Hepat 2019 Jan 12. Epub 2019 Jan 12.

Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland.

Hepatitis E virus (HEV) has traditionally been associated with an acute, self-limiting hepatitis and is not known to have any chronic sequelae. HEV genotypes 1 and 2, which are human pathogens, have been associated with this self-limiting presentation, in both sporadic and epidemic settings. HEV genotype 3, which is zoonotically transmitted, is increasingly being reported as a cause of chronic infection in immunocompromised patients. Read More

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http://doi.wiley.com/10.1111/jvh.13059
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http://dx.doi.org/10.1111/jvh.13059DOI Listing
January 2019
6 Reads

Hepatitis E virus as an agent of hepatocellular carcinoma.

Int J Infect Dis 2019 Jan 10;80:62-63. Epub 2019 Jan 10.

Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes, Evolution, Phylogeny and Infection (MEΦI), Institut Hospitalo-Universitaire (IHU) - Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Assistance Publique - Hôpitaux de Marseille (AP-HM), Centre Hospitalo-Universitaire Timone, Service d'Hépatologie-Gastrologie-Entérologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France.

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http://dx.doi.org/10.1016/j.ijid.2018.12.015DOI Listing
January 2019

[The hepatitis E virus, an unknown virus that reveals itself].

Med Sci (Paris) 2018 Dec 9;34(12):1071-1078. Epub 2019 Jan 9.

Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204-CIIL- Center for Infection and Immunity of Lille 1, rue du Professeur Calmette, F-59000 Lille, France.

The first cause of acute hepatitis in the world is due to the hepatitis E virus (HEV). This infection has long been considered as a problem only affecting developing countries. However, since the identification of zoonotic forms at the end of the last century, it has become clear that this infection also affects industrialized countries. Read More

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http://dx.doi.org/10.1051/medsci/2018299DOI Listing
December 2018
2 Reads