Search Our Scientific Publications & Authors

J Virol Methods 2019 Apr 17. Epub 2019 Apr 17.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, Japan. Electronic address:

Hepatitis E, which is caused by hepatitis E virus (HEV), is generally a self-limiting, acute, and rarely fatal disease. It is sometimes fulminant and lethal, especially during pregnancy. Indeed, it occasionally takes a chronic course in immunocompromised individuals. Read More

J Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

Laboratory of Liver Infectious Diseases, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Background: Hepatitis E virus infection (HEV) is an emerging problem in developed countries. Diagnosis of HEV infection is based on the detection of HEV-specific antibodies, viral RNA and/or antigens (Ag). Humanized mice were previously reported as a model for the study of HEV infection, but published data was focused on the quantification of viral RNA. Read More

Sci Rep 2019 Apr 18;9(1):6243. Epub 2019 Apr 18.

Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL- Center for Infection and Immunity of Lille, F-59000, Lille, France.

Hepatitis E Virus (HEV) genome encodes three proteins including the ORF2 capsid protein. Recently, we demonstrated that HEV produces three different forms of ORF2: (i) the ORF2i form (infectious ORF2) which is the component of infectious particles, (ii) the secreted ORF2g (glycosylated ORF2) and ORF2c (cleaved ORF2) forms that are not associated with infectious particles, but are the major antigens in HEV-infected patient sera. The ORF2 protein sequence contains three highly conserved potential N-glycosylation sites (N1, N2 and N3). Read More

Ther Adv Infect Dis 2019 Jan-Dec;6:2049936119837162. Epub 2019 Apr 3.

Truro, Cornwall, UK.

Hepatitis E virus (HEV) is the most common cause of viral hepatitis in the world. It is estimated that millions of people are infected every year, resulting in tens of thousands of deaths. However, these estimates do not include industrialized regions and are based on studies which employ assays now known to have inferior sensitivity. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Apr;53(4):382-387

National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

To analyze the changing epidemiological characteristics of hepatitis E cases in China, in order to promote in preventing and controlling hepatitis E. Data of hepatitis E and outbreaks reported through national notifiable diseases reporting system were analyzed from 2004 to 2017, but data of Hongkong, Macau and Taiwan were not included. Data of hepatitis E were divided into three phases as 2004-2007, 2008-2011 and 2012-2017, representing eight years before, four years before and years after the postmarketing of hepatitis E vaccine. Read More

Transpl Infect Dis 2019 Apr 11:e13093. Epub 2019 Apr 11.

Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.

BACKGROUND AND AIMS: It has been recently suggested that occult hepatitis C virus (HCV) infection and hepatitis E virus (HEV) reactivation might occur after direct acting antiviral agent-induced (DAA-induced) sustained virological response (SVR). The aim of our study was to identify occult HCV and HEV infection in a cohort of organ transplant patients who had achieved SVR and had persistent elevation in liver-enzyme levels.

Patients And Method: Sixty-six liver and/or kidney transplant patients were treated with DAAs. Read More

Transbound Emerg Dis 2019 Apr 8. Epub 2019 Apr 8.

Animal Health Department, University of Cordoba, Cordoba, Spain.

Hepatitis E virus (HEV) is an emerging zoonotic pathogen that has been detected in different animal species. A survey study was carried out to assess HEV infection in nonhuman primates (NHPs) housed in zoos in Spain. Anti-HEV antibodies were detected in eight of the 181 NHPs tested (4. Read More

Infect Genet Evol 2019 Apr 6;71:215-223. Epub 2019 Apr 6.

Department of Medical Microbiology and Immunology, Medical School, University of Pécs, Pécs, Hungary. Electronic address:

Astroviruses (family Astroviridae) and hepeviruses (family Hepeviridae) are small, non-enveloped viruses with genetically diverse +ssRNA genome thought to be enteric pathogens infecting vertebrates including humans. Recently, many novel astro- and hepatitis E virus-like +ssRNA viruses have been described from lower vertebrate species. The non-structural proteins of astro- and hepeviruses are highly diverse, but the structural/capsid proteins represent a common phylogenetic position shed the light of their common origin by inter-viral recombination. Read More

Front Cell Infect Microbiol 2019 19;9:52. Epub 2019 Mar 19.

Laboratory of Animal Pathology and Public Health, Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, China.

Extrahepatic injury, particularly neurologic dysfunctions such as Guillain-Barré syndrome, neurologic amyotrophy, and encephalitis/meningoencephalitis/myositis were associated with HEV infection, which was supported by both clinical and laboratory studies. Thus, it is crucial to figure out how the virus invades into the central nervous system (CNS). In this study, CNS lesions were determined in rabbits and Mongolian gerbils inoculated with genotype 4 HEV. Read More

Transpl Infect Dis 2019 Mar 31:e13088. Epub 2019 Mar 31.

Institute for Virology, University Hospital Essen, University Duisburg-Essen, Duisburg, Germany.

Background: Hepatitis E virus (HEV) genotype 3 infection frequently progresses to chronic disease with persisting HEV viremia in immunocompromised patients. Here, we evaluated the prevalence of HEV infection in renal allograft recipients and investigated the efficacy and tolerability of ribavirin monotherapy.

Methods: A total of 947 recipients on average 8. Read More

J Med Virol 2019 Mar 28. Epub 2019 Mar 28.

Department of Biotechnology, Gauhati University, Guwahati, Assam, India.

microRNAs (miRNAs) are small, noncoding RNAs which regulate eukaryotic gene expression via RNA interference pathway. Recently, miRNAs have been identified in a number of viruses with current evidence suggesting that they regulate gene expression in both virus and host. This makes viral miRNAs potential targets of clinical intervention, with the possibility of inhibiting aberrant host gene expression associated with the disease. Read More

Pathog Dis 2019 Mar;77(2)

Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian National Workers Compensation Authority, Rome, Italy.

Emerging viral infections represent a public health risk pointed out by the spreading of pathogens with potential zoonotic risk. Moreover, the risk of zoonosis has probably been underestimated in occupational settings. A literature review between 2007 and 2018 was performed to identify evidences concerning the epidemiological associations between some emerging viruses and occupational diseases. Read More

Med Microbiol Immunol 2019 Mar 22. Epub 2019 Mar 22.

Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.

Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in many parts of the world but only a few cases have been diagnosed in Norway. To investigate the HEV exposure rate in a presumed low-risk area, we have conducted a population-based study of anti-HEV IgG seroprevalence in Northern Norway. A total of 1800 serum samples from 900 women and 900 men, age 40-79 years, were randomly selected from the 21,083 participants in the 7th Tromsø Study, representing the 32,591 inhabitants of the Tromsø municipality that were ≥ 40 years. Read More

Clin Gastroenterol Hepatol 2019 Apr;17(5):1004-1006

Department of Internal Medicine IV, Jena University Hospital, Jena, Germany.

J Virol 2019 Mar 20. Epub 2019 Mar 20.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China

Avian hepatitis E virus (HEV) is the main causative agent of big liver and spleen disease in chickens. Due to the absence of a highly effective cell culture system, there are few reports about the interaction between avian HEV and host cells. In this study, organic anion transporting polypeptide 1A2 (OATP1A2) from the chicken liver cells was identified to interact with ap237, a truncated avian HEV capsid protein spanning amino acids 313 to 549, by the GST pull-down assay. Read More

BMC Infect Dis 2019 Mar 19;19(1):269. Epub 2019 Mar 19.

University Hospital for Infectious Diseases "Dr. Fran Mihaljevic", Mirogojska 8, 10 000, Zagreb, Croatia.

Background: To fulfill epidemiological data and investigate possible interspecies transmission, this study shall attempt to sequence representative HEV strains of human, swine and wild boar origin collected from 2010 to 2017 in Croatia.

Methods: In total, 174 anti-HEV antibody positive human sera samples; 1419 blood or faeces samples of swine, as well as 720 tissue and/or blood samples of wild boar originating from different counties (18 in total) in Croatia were tested for the presence of HEV RNA.

Results: HEV RNA was detected in 26 human sera samples (14. Read More

Eur J Clin Microbiol Infect Dis 2019 Mar 19. Epub 2019 Mar 19.

University Department of Advanced Medical and Surgical Sciences, Clinical Department of Internal Medicine and Specialistic Units (DAI), University of Campania "Luigi Vanvitelli", Naples, Italy.

In recent years, the seroprevalence of anti-hepatitis E virus immunoglobulins (HEV) has increased in European countries with significant variability among the different geographical areas. HEV infection is spread in a wide range of animal species of which domestic pigs and wild boar represent the main reservoirs of genotype 3 and 4 (the genotypes present also in Europe). European citizens are incidental hosts, mainly infected by direct contact or consumption of foods derived from undercooked or insufficient hygiene handling infected pork products or wild boar meat. Read More

Antimicrob Agents Chemother 2019 Mar 18. Epub 2019 Mar 18.

School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales, Sydney, NSW, Australia

Globally, hepatitis E virus (HEV) causes significant morbidity and mortality each year. Despite this burden, there are no specific antivirals available to treat HEV patients, and the only licensed vaccine is not available outside of China. Ribavirin and interferon-α are used to treat chronic HEV infections, however severe side effects and treatment failure are commonly reported. Read More

Zoonoses Public Health 2019 05 18;66(3):265-275. Epub 2019 Mar 18.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Hepatitis E virus (HEV) infection remains an important public health problem, and it is endemic primarily in developing countries. This study aimed to evaluate the seroprevalence of HEV among the general population, occupational population and swine in mainland China and its risk factors based on a systematic review and meta-analysis. Systematic search from EMBASE, PubMed, Web of Science, Cochrane Library and several Chinese databases, such as Wanfang (WF) Data, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP) and SINOMED, was searched from inception up to 25 April 2018. Read More

Intractable Rare Dis Res 2019 Feb;8(1):43-47

Department of Virology, Institute of Liver and Biliary Sciences, New Delhi, India.

Hepatitis E is a serious public health problem in developing countries. Most of the patients with Hepatitis E virus (HEV) infection present with typical acute hepatitis symptoms. However, in few patients it may lead to complications such as liver failure and extrahepatic symptoms. Read More

Transplant Proc 2019 Mar 28;51(2):376-379. Epub 2018 Oct 28.

Section of Pulmonary Medicine, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

Background: Hepatitis E virus (HEV) is one of the common causes of acute and chronic viral hepatitis with a global distribution. Genotypes 1 and 2 only affect humans and produce acute hepatitis epidemics in endemic regions (Asia, Africa). In nonendemic areas (America, Europe), genotypes 3 and 4 are considered a zoonosis and cause sporadic acute hepatitis. Read More

Infect Genet Evol 2019 Mar 12;71:16-20. Epub 2019 Mar 12.

Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università, 10, 35020 Legnaro, Padova, Italy.

Hepatitis E virus (HEV) is an emerging zoonosis caused by a positive RNA single stranded virus of the Hepeviridae family. In developed countries, pigs and wild boars are the main reservoir for zoonotic genotypes 3 and 4. In spring 2017, for the first time HEV was detected in wild boars captured in the Regional Park of the Euganean Hills, in north-eastern Italy. Read More

Front Vet Sci 2019 27;6:50. Epub 2019 Feb 27.

National Veterinary Institute, Technical University of Denmark, Kongens Lyngby, Denmark.

Pigs are considered the main reservoir of genotypes 3 and 4 of the human pathogen hepatitis E virus (HEV). These viruses are prevalent at a high level in swine herds globally, meaning that consumers may be exposed to HEV from the food chain if the virus is present in pigs at slaughter. The aim of this study was to determine the HEV infection dynamics from birth to slaughter using 104 pigs from 11 sows in a single production system. Read More

Viruses 2019 Mar 13;11(3). Epub 2019 Mar 13.

Robert Koch Institute, 13353 Berlin, Germany.

Hepatitis (HEV) is widely distributed in pigs and is transmitted with increasing numbers to humans by contact with pigs, contaminated food and blood transfusion. The virus is mostly apathogenic in pigs but may enhance the pathogenicity of other pig viruses. In humans, infection can lead to acute and chronic hepatitis and extrahepatic manifestations. Read More

Rev Prat 2018 Mar;68(3):286-290

Département de néphrologie et transplantation d'organes, hôpital Rangueil. Inserm UMR1043, centre de physiopathologie de Toulouse-Purpan. Université Toulouse-III Paul-Sabatier CHU de Toulouse, Toulouse, France.

Hepatitis E virus infection. Hepatitis E virus (HEV) infection is currently recognized as an endemic pathogen in developed countries, especially in Western Europe. In these regions, HEV is a zoonotic agent and is mainly transmitted by the consumption of under cooked pig or game meat. Read More

Epidemiol Infect 2019 Jan;147:e92

Central Virology Laboratory, Ministry of Health, Public Health Services, The Chaim Sheba Medical Center,Tel Hashomer, Ramat-Gan,Israel.

Hepatitis E virus (HEV) is an emerging cause of viral hepatitis worldwide. Recently, HEV-7 has been shown to infect camels and humans. We studied HEV seroprevalence in dromedary camels and among Bedouins, Arabs (Muslims, none-Bedouins) and Jews and assessed factors associated with anti-HEV seropositivity. Read More

Clin Lab 2019 Mar;65(3)

Background: Nepal is an endemic area for hepatitis E virus (HEV) epidemics. The research on viral hepatitis in Nepal is limited.

Methods: Serum samples from 170 patients presenting with symptoms of hepatitis were collected from April to May 2014 in Biratnagar, Nepal, and then transported to Xiamen, China, for further evaluation. Read More

Sci Rep 2019 Mar 13;9(1):4397. Epub 2019 Mar 13.

Department of Life Science, Gachon University, Seongnam-Si, 13120, Korea.

Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans worldwide. Although hepatitis E is self-limiting without chronic infection development, HEV infection often leads to severe liver diseases causing high mortality in pregnant women in addition to chronic hepatitis and cirrhosis in immunosuppressed patients. In this study, we investigated the effect of a Liriope platyphylla ethanol extract (LPE) on HEV replication. Read More

BMC Vet Res 2019 Mar 12;15(1):87. Epub 2019 Mar 12.

Department of Virology II, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan.

Background: Hepatitis E virus (HEV) is prevalent in pigs and may serve as a reservoir for human infection. However, data on HEV infections in pigs in Ibaraki Prefecture, Japan, are limited. Here, we clarified the process and course of HEV in naturally infected pigs. Read More

J Epidemiol Glob Health 2018 Dec;8(3-4):203-207

Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Waterborne diseases, such as hepatitis A and E, are a major public health concern in most developing countries, indicating the need for proper outbreak prevention, surveillance, and timely management. This study presents data regarding the prevalence and epidemiological characteristics of hepatitis A and E outbreaks as well as water quality in Kashmir, India, during 2015-2017. Hepatitis outbreaks were initially investigated by rapid response teams, under the Integrated Disease Surveillance Programme. Read More

Cent Asian J Glob Health 2018 22;7(1):324. Epub 2018 Feb 22.

Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan.

Introduction: Hepatitis E virus exposure is associated with sporadic cases of acute hepatitis and outbreaks in many countries worldwide. It is particularly dangerous for pregnant women, in whom the mortality rate is high. There are no previously published data reporting circulation of this virus in Kazakhstan. Read More

Euro Surveill 2019 Mar;24(10)

Blood Borne Virus Unit, Virus Reference Department, Microbiology Services and National Infection Services, Public Health England, London, United Kingdom.

IntroductionHepatitis E virus (HEV), the most common cause of acute hepatitis in many European countries, is transmitted through consumption of processed pork but also via blood transfusion and transplantation. HEV infection can become persistent in immunocompromised individuals.AimWe aimed to determine the incidence and epidemiology of HEV infection in English blood donors since the introduction of donation screening in 2016. Read More

Euro Surveill 2019 Mar;24(10)

National Reference Centre of Hepatitis Viruses, Viral Diseases, Infectious Diseases in Humans, Sciensano, Brussels, Belgium.

BackgroundHepatitis E virus (HEV) is an emerging public health concern in high-income countries and can cause acute and chronic hepatitis. Reported numbers of indigenously acquired HEV infection have increased in the past decade in many European countries. Since 2010, the National Reference Centre (NRC) for Hepatitis Viruses has been testing samples of suspected hepatitis E cases in Belgium. Read More

Euro Surveill 2019 Mar;24(10)

The members of HEVnet are listed at the end of the article.

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. In Europe, HEV is a zoonosis transmitted via contaminated pork meat or other pork food products. Genotype 3 is the most prevalent HEV type in the animal reservoir, as well as in humans. Read More

Transpl Infect Dis 2019 Mar 12:e13065. Epub 2019 Mar 12.

Department of Nephrology, Dialysis and Organs Transplantation, INSERM U1043, IFR -BMT, CHU Rangueil, University Paul Sabatier, Toulouse, France.

Sci Rep 2019 Mar 11;9(1):4090. Epub 2019 Mar 11.

Hepatitis Group, Indian Council of Medical Research- National Institute of Virology, 130/1, Sus Road, Pashan, Pune, 411021, Maharashtra, India.

Generation and persistence of anti-hepatitis E virus (HEV) antibodies are synonymous with the development of immunity and considered as correlates of protection against HEV infection. However, issues like longevity of immunological memory following recovery from hepatitis E still remains a puzzle. It is critical to understand whether anamnestic response exists for protection from HEV re-infection. Read More

J Med Virol 2019 Mar 9. Epub 2019 Mar 9.

Department of Transfusion Medicine, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.

Hepatitis B e-antigen (HBeAg) is the secretory form of the nucleocapsid of the hepatitis B virus (HBV), which is a marker of viral replication. In this study, a novel signal amplification system (SAS) based on the lateral flow immunoassay (LFIA) was used for rapid detection of HBeAg in blood samples from patients or blood donors. In this assay, the detection antibody was conjugated with gold nanoparticles (GNPs), and the capture antibody was labeled with biotin. Read More

Int J Food Microbiol 2019 May 26;296:58-64. Epub 2019 Feb 26.

National Institute of Public Health and the Environment (RIVM), Anthonie van Leeuwenhoeklaan 9, 3721 MA Bilthoven, the Netherlands. Electronic address:

The aim of the present study was to assess pork liver and meat products present on the Dutch market for the presence of hepatitis E virus (HEV) RNA. HEV RNA was detected in 27.3% of 521 products sampled from Dutch retail stores in 2016. Read More

Virus Res 2019 May 2;265:30-33. Epub 2019 Mar 2.

Key Laboratory of Public Health Safety (Ministry of Education), Fudan University School of Public Health, Shanghai, 200032, China; Fudan University Pudong Institute of Preventive Medicine, Shanghai, 200136, China. Electronic address:

Hepatitis E virus (HEV) has been divided into eight genotypes and approximately thirty subtypes. Past studies of blood donors have revealed a substantial prevalence of HEV infection. We examined anti-HEV antibodies and HEV RNA in Chinese voluntary blood donors (VBDs). Read More

Braz J Infect Dis 2019 Jan - Feb;23(1):45-52. Epub 2019 Mar 2.

Universidade Federal de São Paulo, Divisão de Doenças Infeccionsas, Departamento de Medicina, São Paulo, SP, Brazil.

Background: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance. Read More

Open Access Maced J Med Sci 2019 Feb 25;7(3):458-460. Epub 2019 Jan 25.

Department of Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria.

Background: Over the past two decades, more thorough investigations for hepatitis E virus (HEV) infection have been done in the world. Reports from Southeast European countries have increased.

Aim: The current article presents a critical analysis of all studies for HEV in Bulgaria. Read More

Am J Primatol 2019 Mar 4;81(3):e22961. Epub 2019 Mar 4.

Instituto Pri-Matas para a Conservação da Biodiversidade, Belo Horizonte, MG, Brazil.

The world currently faces severe biodiversity losses caused by anthropogenic activities such as deforestation, pollution, the introduction of exotic species, habitat fragmentation, and climate changes. Disease ecology in altered environments is still poorly understood. The golden-headed lion tamarin (GHLT, Leontopithecus chrysomelas) is an endangered species that became invasive in an urban park in Niterói, Rio de Janeiro, Brazil. Read More

Vet Microbiol 2019 Mar 13;230:244-248. Epub 2019 Feb 13.

Department of Virology II, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashi-murayama, Tokyo, 208-0011, Japan. Electronic address:

Rhesus and several other species of monkeys are susceptible to genotypes of hepatitis E virus (HEV), and these species are thus commonly used as animal models for experimental HEV infection. However, information regarding HEV infection in monkeys in nature or at monkey farms is limited. To investigate the status of HEV infection in rhesus monkeys at farms, we collected 548 serum and 48 fecal samples from a rhesus monkey farm in China, and analyzed their levels of anti-HEV IgG antibodies and HEV RNAs. Read More

Braz J Infect Dis 2019 Jan - Feb;23(1):40-44. Epub 2019 Feb 28.

Mansoura University, Faculty of Medicine, Department of Medical Microbiology and Immunology, Mansoura, Egypt.

Hepatitis E virus (HEV) infection is one of the major public health problems in developing countries. HEV can cause chronic infections in immunocompromised individuals e.g. Read More

Clin Transplant 2019 Feb 28:e13514. Epub 2019 Feb 28.

Division of Infectious Diseases, University of Alberta, Edmonton, Alberta, Canada.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of viral hepatitis in the pre- and post-transplant period. The current guidelines reflect the declining need for hepatitis B immunoglobulin following liver transplant, now replaced with nucleos(t)ide analogues that effectively suppress viral replication for the long term with minimal risk for drug resistance. It describes the limitations of pegylated interferon alpha in the treatment for chronic hepatitis D. Read More

J Obstet Gynaecol India 2019 Feb 22;69(1):31-36. Epub 2018 Mar 22.

Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College, Sion, Mumbai, 400022 India.

Background: Incidence of jaundice in pregnancy, including underlying chronic liver diseases, is 3-5%. However, the maternal mortality rate in some conditions can be as high as 18% in acute fatty liver of pregnancy and 22% in hepatitis E in pregnancy.

Objectives: This is an observational study of the demographics, obstetrical profile, aetiology, maternal morbidity, mortality and neonatal outcomes in pregnancies complicated with jaundice. Read More

Indian J Nephrol 2019 Jan-Feb;29(1):50-52

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Monoclonal gammopathy of undetermined significance does not have end organ damage, but a proportion of cases manifest with renal injury when it is called monoclonal gammopathy of renal significance (MGRS). Herein, we describe a case of acute hepatitis E infection, which precipitated the development of MGRS. The patient underwent kidney biopsy for elevated creatinine with clinical suspicion of drug-induced interstitial nephritis. Read More

Viruses 2019 Feb 22;11(2). Epub 2019 Feb 22.

Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Hepatology Service, Institut National de la Santé et de la Recherche Médicale unité 1223, Institut Pasteur, 75006 Paris, France.

Hepatitis E virus (HEV) infection is a pandemic with regional outbreaks, including in industrialized countries. HEV infection is usually self-limiting but can progress to chronic hepatitis E in transplant recipients and HIV-infected patients. Whether other immunocompromised hosts, including rheumatology and internal medicine patients, are at risk of developing chronic HEV infection is unclear. Read More

Transbound Emerg Dis 2019 Feb 27. Epub 2019 Feb 27.

Faculty of Veterinary Medicine, Università degli Studi di Teramo, Teramo, Italy.

Hepatitis E virus (HEV) is the leading cause of human enterically transmitted viral hepatitis occurring around the world both as outbreaks and as sporadic cases. The accumulating literature indicates that domestic pigs and wild boars are the main reservoirs of genotype 3 and genotype 4 for human infections in industrialized countries. However, the recent identification of HEV from various animal species poses additional potential concerns for HEV zoonotic infection. Read More

Clin Res Hepatol Gastroenterol 2019 Feb 23. Epub 2019 Feb 23.

Liver unit, University Hospitals Birmingham, United Kingdom.

Hepatitis E virus (HEV) typically causes an acute, self-limiting hepatitis and is among the commonest cause of such presentations. Hepatitis E viral infection is also increasingly recognized as a cause of chronic hepatitis amongst the immunocompromised, particularly amongst solid organ transplant recipients. Chronic HEV infection remains an underdiagnosed disease and chronic infection can lead to rapidly progressive liver fibrosis and cirrhosis. Read More