4,874 results match your criteria Hepatitis E


Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening.

Biomed Res Int 2018 30;2018:5753804. Epub 2018 Aug 30.

School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.

The hepatitis E virus- (HEV-) helicase as a novel drug-target was evaluated. While cell culture model was used for mutational characterization of helicase, protein modeling and virtual screening were employed to identify helicase inhibitors. None of the saturation mutant replicons significantly affected RNA replication. Read More

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Detection of hepatitis E virus genotype 3 in pigs from subsistence farms in the state of Mato Grosso, Brazil.

Comp Immunol Microbiol Infect Dis 2018 Jun 13;58:11-16. Epub 2018 Jun 13.

Laboratory of Veterinary Pathology, Universidade Federal de Mato Grosso (UFMT), Av. Fernando Corrêa da Costa, 2367, Boa Esperança, CEP 78069-900, Cuiabá, Mato Grosso, Brazil. Electronic address:

Hepatitis E is a zoonotic disease, recognized as an important global public health concern. In this study, molecular detection of the ORF1 and ORF2 genomic regions of the hepatitis E virus (HEV) was carried out in fecal and serum samples from pigs in subsistence farms of Mato Grosso, Brazil. Fragments of the ORF2 region were amplified in 8% (12/150) of fecal samples, with 53. Read More

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Key Characteristics of Foods with an Elevated Risk for Viral Enteropathogen Contamination.

J Appl Microbiol 2018 Sep 23. Epub 2018 Sep 23.

University of Arkansas, Division of Agriculture, Department of Food Science, Fayetteville, AR, 72704.

Viral enteropathogens are one of the leading causative agents of foodborne illnesses in both the United States and the European Union. While human noroviruses (hNoV) and Hepatitis A virus (HAV) cause the vast majority of outbreaks and illnesses, there are handful of human enteric viruses that contribute to sporadic outbreaks worldwide including astrovirus, sapovirus, rotavirus, enterovirus, and Aichi virus. In addition, Hepatitis E virus is increasingly being recognized as an emerging zoonotic threat within the food supply. Read More

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September 2018

Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management.

Kidney Int 2018 Oct;94(4):663-673

Division of Hepatology, University of Miami, Miami, Florida, USA. Electronic address:

Infection with the hepatitis C virus (HCV) has adverse liver, kidney, and cardiovascular consequences in patients with chronic kidney disease (CKD), including those on dialysis therapy and in those with a kidney transplant. Since the publication of the original Kidney Disease: Improving Global Outcomes (KDIGO) HCV Guideline in 2008, major advances in HCV management, particularly with the advent of direct-acting antiviral therapies, have now made the cure of HCV possible in CKD patients. In addition, diagnostic techniques have evolved to enable the noninvasive diagnosis of liver fibrosis. Read More

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October 2018

Occult Hepatitis B Infection Among Blood Donors in Al Azhar University Hospital, Upper Egypt: The Current Status After 25 years of Vaccine Introduction.

Egypt J Immunol 2018 Jan;25(1):45-56

Department of Medical Microbiology & Immunology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Occult hepatitis B virus infection (OBI) is a challenging topic with much debate regarding its clinical and virological relevance. The reliance on anti HBc seropositivity for diagnosis of OBI is still controversial. We aimed to determine the frequency of OBI among Egyptian blood donors, the role of anti HBc and HBe Ag as predictors of OBI and the possible risk factors. Read More

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January 2018

Cloning and expression of truncated ORF2 as a vaccine candidate against hepatitis E virus.

3 Biotech 2018 Oct 15;8(10):414. Epub 2018 Sep 15.

1Department of Biotechnology, Jaypee Institute of Information Technology, Noida, UP 201309 India.

Hepatitis E virus infection is responsible for acute viral hepatitis and associated with high mortality and still birth in pregnant women in developing countries. We report expression of truncated forms of HEV ORF2 as potential vaccine candidates for nanoparticle-based delivery. These two truncated ORF2 proteins (54 kDa and 26 kDa) have been reported to be highly immunogenic and can be used as nanoparticle-based vaccine candidate. Read More

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October 2018
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Hepatitis E infection in Odisha, India: A descriptive analysis.

Indian J Public Health 2018 Jul-Sep;62(3):231-234

Deputy Director General, Development and Delivery, International Vaccine Institute, Seoul, South Korea.

Up to 25% of hepatitis E virus (HEV)-infected pregnant women in their third trimester die. Despite HEV being an important cause of viral hepatitis, no robust surveillance exists in India. We reviewed jaundice outbreaks records and hospital records from jaundiced individuals seeking treatment and linked those records to laboratory results (HEV immunoglobulin M enzyme-linked immunosorbent assay) for January 2012 to September 2013 in Odisha state. Read More

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September 2018

Hepatitis E infection in solid organ transplant recipients: An overlooked diagnosis?
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Clin Nephrol 2018 Sep 20. Epub 2018 Sep 20.

Hepatitis E virus (HEV) is gaining recognition as an important but under-recognized pathogen, particularly in immunocompromised individuals. It should be considered as a potential differential diagnosis in such patients presenting with acute hepatitis. We report a case of a kidney-pancreas transplant recipient who developed acute liver dysfunction; this was found to be due to HEV infection acquired through consumption of undercooked pork. Read More

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September 2018

Hepatitis E virus genotype 3 is a common finding in liver transplanted patients undergoing liver biopsy for elevated liver enzymes with a low de Ritis ratio and suspected acute rejection: a real world cohort.

Clin Transplant 2018 Sep 19:e13411. Epub 2018 Sep 19.

First Department of Internal Medicine, Gastroenterology and Hepatology, Universitätsmedizin Mainz, Mainz, Germany.

Background: Hepatitis E virus (HEV) infection is a potential reason for elevated liver enzymes after liver transplantation (LT). Our aim was to analyze a real world cohort of LT patients, who underwent liver biopsy for elevated transaminases and suspected acute rejection, to evaluate frequency of post-transplant HEV infection.

Patients: Data from 160 liver biopsies were analyzed. Read More

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September 2018

Hepatitis E virus infection in Wuhan, Central China.

Arch Virol 2018 Sep 18. Epub 2018 Sep 18.

Wuhan Center for Disease Control and Prevention, Wuhan, Hubei, China.

Hepatitis E virus (HEV) is an emergent virus of global importance. Previous studies of HEV infection in China mainly focused on the rural areas. This work aims to study the epidemiology of HEV in a large urban environment. Read More

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September 2018

Epidemiology of viral hepatitis in Somalia: Systematic review and meta-analysis study.

World J Gastroenterol 2018 Sep;24(34):3927-3957

Center For the study of the Liver, Department of Hospital Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.

Aim: To provide a clear understanding of viral hepatitis epidemiology and their clinical burdens in Somalia.

Methods: A systematic review and meta-analysis was conducted as Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search of published studies on viral hepatitis was performed from 1977-2016 in PubMed, Google Scholar, Science Direct, World Health Organization African and the Africa Journals Online databases, as well as on the Ministry of Health website. Read More

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September 2018

A case of incidental infection of Hepatitis E virus (HEV) genotype 1 in a domestic pig.

Arch Virol 2018 Sep 15. Epub 2018 Sep 15.

Sección Virologia, Facultad de Ciencias Universidad de la República, Igua 4225, 11400, Montevideo, Uruguay.

Hepatitis E virus (HEV) infection involving zoonotic genotypes is a public health problem in high-income and non-endemic developing countries. Herein we report the detection of a human genotype 1 (HEV-1) strain infecting a domestic pig, which is not considered a natural reservoir of this genotype. Viral load was quantified in stool by Real-Time qPCR and sequence analyses were performed. Read More

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September 2018

Hepatitis E Virus infection seroprevalence and the associated risk factors in animals raised in Ibadan, Nigeria.

J Immunoassay Immunochem 2018 Sep 13:1-12. Epub 2018 Sep 13.

a Department of Veterinary Pathology , University of Ibadan , Ibadan , Nigeria.

Hepatitis E (HE) is an important viral hepatitis of global public and livestock health, and food security significance due to the ubiquitous distribution, multiple transmission route and zoonotic potentials. HE is also endemic in most developing countries including Nigeria. This study therefore investigates the seroprevalence and associated risk factors of HEV infection in pigs raised in Ibadan, Nigeria. Read More

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September 2018

Viability RT-qPCR to Distinguish Between HEV and HAV With Intact and Altered Capsids.

Front Microbiol 2018 24;9:1973. Epub 2018 Aug 24.

Department of Preservation and Food Safety Technologies, Instituto de Agroquímica y Tecnología de Alimentos - Consejo Superior de Investigaciones Científicas, Valencia, Spain.

The hepatitis E virus (HEV) is an emerging pathogen showing a considerable increase in the number of reported cases in Europe mainly related to the ingestion of contaminated food. As with other relevant viral foodborne pathogens, real-time reverse transcriptase polymerase chain reaction (RT-qPCR) is the gold standard for HEV detection in clinical, food, and environmental samples, but these procedures cannot discriminate between inactivated and potentially infectious viruses. Thus, the aim of this study was to develop a viability PCR method to discriminate between native, heat-, and high-pressure processing (HPP)-treated HEV using the hepatitis A virus (HAV) as a cultivable surrogate. Read More

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August 2018
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Aetiology of viral hepatitis among jaundiced patients presenting to a tertiary hospital in Ghana.

PLoS One 2018 12;13(9):e0203699. Epub 2018 Sep 12.

Department of Clinical Microbiology, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: Viral hepatitis continues to play significant role in causing morbidity and mortality in sub-Saharan Africa. Apart from the few population based studies available, not many have investigated the burden of these viruses in jaundiced patients. Among the few studies, hepatitis E is the least studied among jaundiced patients. Read More

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September 2018
4 Reads
3.23 Impact Factor

Molecular survey of HEV infection in wild boar population in Italy.

Transbound Emerg Dis 2018 Sep 11. Epub 2018 Sep 11.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.

Hepatitis E virus (HEV) is an RNA virus causing an acute generally self-limited disease in humans. An increasing number of autochthonous cases linked to zoonotic transmission of HEV genotype 3 have been reported over the last 10 years in Europe. Pigs and wild boars are considered the main reservoirs. Read More

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September 2018
4 Reads

Hepatitis A Virus, Hepatitis E Virus, and Rotavirus in Foods of Animal Origin Traded at the Borders of Brazil, Argentina, and Uruguay.

Food Environ Virol 2018 Sep 11. Epub 2018 Sep 11.

Universidade Federal de Pelotas, Campus Capão do Leão. Avenida Eliseu Maciel, SN, Capão do Leão, RS, CEP 96010900, Brazil.

The aim of this study was to investigate hepatitis A virus (HAV), hepatitis E (HEV), and rotavirus (RV) in fresh and processed meat traded on the border of Brazil with Argentina and Uruguay. In total, 159 samples of raw and processed foods of animal origin were collected in Paso de los Libres, Argentina (n = 53 raw meat, n = 24 processed meat) and Rivera, Uruguay (n = 55 raw meat, n = 18 processed meat), or were seized by the Brazilian International Agricultural Surveillance System-VIGIAGRO (Brazil-Argentina border) (n = 8 raw meat, n = 1 bush meat). All samples were tested for the presence of HAV, HEV, and RV genomes. Read More

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September 2018
2 Reads

Identification of a putative novel genotype 3/rabbit hepatitis E virus (HEV) recombinant.

PLoS One 2018 11;13(9):e0203618. Epub 2018 Sep 11.

Infectious Disease Research, Abbott Diagnostics, Abbott Park, Illinois, United States of America.

Hepatitis E virus (HEV) is a viral pathogen transmitted by the fecal-oral route and is a major cause of waterborne acute hepatitis in many developing countries. In addition to infecting humans, HEV has been identified in swine, wild boars, rabbits and other mammals; with swine and wild boars being main reservoirs for zoonotic transmission of HEV. There are four major HEV genotypes known to infect humans; genotypes 1 (HEV-1) and 2 (HEV-2) are restricted to humans, and genotypes 3 (HEV-3) and 4 (HEV-4) are zoonotic. Read More

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September 2018

Phylogenetic analysis of two genotype 3 Hepatitis E viruses from wild boar, Italy.

Virus Genes 2018 Sep 10. Epub 2018 Sep 10.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.

The complete and near-complete genome sequences (7206 nt and 7229 nt) of two wild boar HEV strains detected in Southern Italy were obtained by the next generation sequencing. Phylogenetic analysis and p distance comparisons of one of the strains with HEV-3 reference subtype strains confirmed the detection of a subtype 3i (p distance = 0.110) strain in wild boar, never detected in Italy either in wild boar or pigs. Read More

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September 2018

Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I.

J Microbiol Biotechnol 2018 Sep 10. Epub 2018 Sep 10.

Korea Zoonosis Research Institute & Genetic Engineering Research Institute, Chonbuk National University, Jeonju 561-756, Republic of Korea.

The type I interferons (IFNs) play a vital role in activation of innate immunity in response to viral infection. Accordingly, viruses have evolved to employ various survival strategies to evade innate immune responses induced by type I IFNs. For example, HEV encoded papain-like cysteine protease (PCP) has been shown to inhibit IFN activation signaling by suppressing K63-linked de-ubiquitination of retinoic acid-inducible gene I (RIG-I) and TANK-binding kinase 1 (TBK1), thus effectively inhibiting down-stream activation of IFN signaling. Read More

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September 2018
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[A new era of transfusion-transmitted pathogens, infections. Renewed need for updating standards for clinicans along with blood banking].

Authors:
Miklós Udvardy

Orv Hetil 2018 Sep;159(37):1495-1500

Haematologiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar és Klinikai Központ Debrecen, Nagyerdei krt. 98., 4032.

Preparative and clinical transfusiology and transfusion, a majestic part of clinical medicine saved the life of hundred millions. However, bloodborne or transmitted infections became a serious issue in France in the 1980s, when many haemophiliacs were infected by HIV or hepatitis C virus by receiving plazma FactorVIII concentrates. This resulted in a quick and powerful development of screening as well as pathogen-inactivating methods, which reduced pathogen contamination and transmission to minimal levels. Read More

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September 2018
1 Read

Hepatitis E virus infection in acute non-traumatic neuropathy: A large prospective case-control study in China.

EBioMedicine 2018 Sep 3. Epub 2018 Sep 3.

Department of Pathology and Hepatology, Beijing 302 Hospital, Beijing, China. Electronic address:

Neurological manifestations are potentially associated with hepatitis E virus (HEV) infection in Europe, mainly attributed to genotype (GT) 3 HEV infection. In this study, we determined the frequency and causal relationship of HEV in patients with non-traumatic neurological disorders in China, where GT4 HEV is prevalent. 1117 consecutive patients diagnosed with neurological illnesses in a hospital of eastern China and 1475 healthy controls who took routine examination in the same hospital were tested for HEV by serology and molecular methods. Read More

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September 2018
1 Read

Epidemiology of Hepatitis A and Hepatitis E Based on Laboratory Surveillance Data-India, 2014-2017.

Am J Trop Med Hyg 2018 Sep 4. Epub 2018 Sep 4.

Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.

Hepatitis A and hepatitis E viruses (HAV and HEV) are the most common etiologies of viral hepatitis in India. To better understand the epidemiology of these infections, laboratory surveillance data generated during 2014-2017, by a network of 51 virology laboratories, were analyzed. Among 24,000 patients tested for both HAV and HEV, 3,017 (12. Read More

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September 2018
5 Reads

Conservation and variation of the hepatitis E virus ORF2 capsid protein.

Gene 2018 Oct 2;675:157-164. Epub 2018 Jul 2.

Center for Biomedical Research, Northwest Minzu University, Lanzhou, China; Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address:

Hepatitis E virus (HEV) is one of the major pathogens causing acute viral hepatitis. The infectious particle consists of an RNA genome and capsid proteins. The 7. Read More

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October 2018

Current hepatitis E virus seroprevalence in Swiss blood donors and apparent decline from 1997 to 2016.

Euro Surveill 2018 Aug;23(35)

Interregional Blood Transfusion SRC, Berne Switzerland.

Background and aimHepatitis E virus (HEV) is a virus of emerging importance to transfusion medicine. Studies from several European countries, including Switzerland, have reported high seroprevalence of hepatitis E as a consequence of endemic infections. Published HEV seroprevalence estimates within developed countries vary considerably; primarily due to improved diagnostic assays. Read More

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Short communication: detection and molecular characterization of hepatitis E virus in domestic animals of São Tomé and Príncipe.

Trop Anim Health Prod 2018 Sep 3. Epub 2018 Sep 3.

Epidemiology Research Unit (EPIUnit), Institute of Public Health, University of Porto, 4050-313, Porto, Portugal.

As in most of the African continent, the status of hepatitis E virus (HEV) infection in domestic animals in São Tomé and Príncipe, an archipelago off the western equatorial coast of Central Africa, is also completely unknown. In the present study, we investigated the presence of HEV among domestic animals in São Tomé and Príncipe. A total of 93 stool samples from different animal species (goat, cow, pig, chicken, duck, and monkey) were tested for HEV RNA using two real-time RT-PCR assays, followed by a nested RT-PCR assay for sequencing and phylogenetic analysis. Read More

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September 2018
2 Reads

Hepatitis E Seroprevalence in the United States: Results for Immunoglobulins IgG and IgM.

J Med Virol 2018 Aug 31. Epub 2018 Aug 31.

School of Nursing James Madison University 235 Martin Luther King Jr. Way, Harrisonburg, Virginia.

Background: Previous research identified a decline in Hepatitis E (HEV) seroprevalence in US 1988-1994 and 2009-2010. We investigated most recent HEV epidemiology.

Method: Using a nationally representative sample (7656 persons in NHANES 2013-2014 and 7124 persons in NHANES 2015-2016), we compared the weighted seroprevalence of HEV (IgG/IGM) among US persons (aged >=6 years) between these two-time periods. Read More

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Human hepatitis E virus circulation in Bulgaria: Deep Bayesian phylogenetic analysis for viral spread control in the country.

J Med Virol 2018 Aug 31. Epub 2018 Aug 31.

Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.

Hepatitis E virus (HEV) infection in Bulgaria is endemic, as demonstrated by the seroprevalence of antibody against the virus in the general population and by the high prevalence of clinical cases registered. In this study, a deep Bayesian phylogenetic analysis has been performed to provide information on the genetic diversity and the spread of HEV genotypes in Bulgaria. Three different data sets of HEV virus was built for genotyping by the maximum likelihood method, for evolutionary rate estimated by Bayesian Markov Chain Monte Carlo approach, for demographic history investigation and for selective pressure analysis. Read More

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Hepatitis viruses in Kathmandu, Nepal: hospital-based study.

BMC Res Notes 2018 Aug 30;11(1):627. Epub 2018 Aug 30.

MB Kedia Dental College Private Limited, Birgunj, Nepal.

Objective: The objective of this study was to see the aetiology and outcome of sporadic acute viral hepatitis (AVH) in Kathmandu, Nepal.

Results: Among 210 patients, 94 (45%) were male and 116 (55%) were female. Mean age was 30 years. Read More

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August 2018
2 Reads

Prevalence of hepatitis E virus viremia and antibodies among healthy blood donors in India.

Indian J Gastroenterol 2018 Aug 29. Epub 2018 Aug 29.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.

Background: Hepatitis E virus (HEV) is transmitted primarily through contaminated water and food. Recently, HEV viremia in blood donors and transfusion-related transmission of HEV have been reported, leading to calls to screen donated blood for this virus. However, these data are from regions where genotype 3 HEV is predominant. Read More

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Chronic genotype 1 hepatitis E infection from immunosuppression for ileo-colonic Crohn's disease.

Oxf Med Case Reports 2018 Sep 25;2018(9):omy059. Epub 2018 Aug 25.

Department of Hepatology, University Hospitals of Cambridge, Addenbrookes Hospital, Hills Rd, Cambridge CB2 0QQ, UK.

We report a case of a 33-year-old man with a background of longstanding ileo-colonic Crohn's disease and primary sclerosing cholangitis. Following a trip to India he developed diarrhoea which was treated as an exacerbation of Crohn's disease. Liver tests became chronically deranged after increasing immunosuppression, which comprised mercaptopurine, adalimumab and prednisolone. Read More

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September 2018
1 Read

Abnormal liver function tests in inflammatory arthritis: think beyond the DMARDs.

Oxf Med Case Reports 2018 Sep 25;2018(9):omy058. Epub 2018 Aug 25.

Royal Berkshire NHS Foundation Trust, Royal Berkshire Hospital, Reading RG1 5LE, UK.

Abnormal liver function tests are often seen in patients with inflammatory arthritis. These are commonly associated with disease-modifying anti-rheumatic drugs, however, clinicians must hold a high index of suspicion for less common causes. This article details two of such cases where hereditary haemochromatosis and acute hepatitis E infection were actually responsible for deranged serum liver enzymes. Read More

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September 2018
2 Reads

High circulation of Hepatitis E virus in pigs and professionals exposed to pigs in Laos.

Zoonoses Public Health 2018 Aug 27. Epub 2018 Aug 27.

Lao-Lux-Laboratory, Institute Pasteur du Laos, Vientiane, Lao People's Democratic Republic.

Epidemiological characteristics of hepatitis E Virus (HEV) differ due to the vast spatial heterogeneity in sanitation status, dietary habits and extent of exposure to animals. Although HEV infections are mostly asymptomatic, prognosis is poor for patients with compromised immune systems or pre-existing liver disease and during pregnancy. In developing countries, low hygienic standards and close human-animal interactions at farms and slaughterhouses likely favour zoonotic transmission of the virus. Read More

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August 2018
2 Reads

Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review.

Case Rep Rheumatol 2018 26;2018:6873276. Epub 2018 Jul 26.

Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Read More

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July 2018
2 Reads

Management of Viral Hepatitis in Solid Organ Transplant Recipients.

Infect Dis Clin North Am 2018 09;32(3):635-650

Division of Infectious Diseases, University of Alberta, 11350 83 Avenue, Edmonton, Alberta T6G2G3, Canada. Electronic address:

With potent nucleos(t)ide analogue (NA) therapy, hepatitis B virus (HBV) is now an uncommon indication for liver transplant (LT) in North America. NA therapy, with or without hepatitis B immunoglobulin, results in low recurrence rates and excellent outcomes after LT. Direct-acting antiviral therapy for hepatitis C virus (HCV), results in cure in most patients, either before or after transplant. Read More

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September 2018
3 Reads

Absence of persistent Hepatitis E virus infection in antibody-deficient patients is associated with the transfer of antigen neutralising antibodies from immunoglobulin products.

J Infect Dis 2018 Aug 18. Epub 2018 Aug 18.

Department of Clinical Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom.

Background: Persistent hepatitis E virus (HEV) infection is described in a number of immunosuppressive conditions. We aimed to determine the risk of persistent HEV infection in patients with primary or secondary antibody deficiency.

Methods: Two hundred and forty five antibody deficient patients on regular immunoglobulin replacement were tested for HEV RNA and anti-HEV IgG. Read More

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August 2018
8 Reads

Evidence of hepatitis E virus infections among persons who use crack cocaine from the Midwest region of Brazil.

J Med Virol 2018 Aug 22. Epub 2018 Aug 22.

Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

The present study aimed to determine the seroprevalence of HEV infection among persons who use crack from Midwest region of Brazil. Sera samples from 698 users of crack collected from November 2013 to July 2015 were tested for anti-HEV IgG and IgM markers. Of the 698 serum samples, 99 (14. Read More

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August 2018
1 Read

Hepatitis E Virus Detected in Pork Products.

Food Environ Virol 2018 Aug 20. Epub 2018 Aug 20.

Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, People's Republic of China.

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Ingesting Self-Grown Produce and Seropositivity for Hepatitis E in the United States.

Gastroenterol Res Pract 2018 15;2018:7980413. Epub 2018 Jul 15.

Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Background: Hepatitis E virus (HEV) is a major cause of hepatitis in developing and industrialized countries worldwide. The modes of HEV transmission in industrialized countries, including the United States, remain largely unknown. This study is aimed at evaluating the association between HEV seropositivity and consumption of self-grown foods in the United States. Read More

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July 2018
2 Reads

Association of Toll-like receptor 4 polymorphism with hepatitis E virus-infected Indian patients.

J Viral Hepat 2018 Aug 16. Epub 2018 Aug 16.

ICMR Consultant and Scientist G, National Institute of Virology, Pune, India.

Hepatitis E infection caused by hepatitis E virus (HEV), a major public health concern in developing countries, is responsible for sporadic and epidemic acute viral hepatitis in adults. Pathogenesis of hepatitis E infection is poorly understood. Toll-like receptors (TLRs) are the key players of innate immunity recognize pathogen-associated molecular patterns (PAMPs). Read More

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August 2018
5 Reads

Infection dynamics of hepatitis E virus in wild-type and immunoglobulin heavy chain knockout J (-/-) gnotobiotic piglets.

J Virol 2018 Aug 15. Epub 2018 Aug 15.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061

Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important but incompletely understood pathogen causing high mortality during pregnancy and leading to chronic hepatitis in immunocompromised individuals. The underlying mechanisms leading to hepatic damage remain unknown; however, the humoral immune response is implicated. In this study, immunoglobulin (Ig) heavy chain J (-/-) knockout gnotobiotic pigs were generated using CRISPR/Cas9 technology to deplete the B-lymphocyte population resulting in an inability to generate a humoral immune response to genotype 3 HEV infection. Read More

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August 2018
5 Reads
4.44 Impact Factor

Hepatitis E infection in stem cell and solid organ transplantpatients: A cross-sectional study: The importance of HEV RNA screening in peri-transplant period.

J Clin Virol 2018 Oct 29;107:1-5. Epub 2018 Jul 29.

Royal Free Hospital NHS Foundation Trust, London, UK.

Background: Hepatitis E Virus (HEV) is a common cause of acute viral hepatitis worldwide. Typically associated with a self-limiting illness, infection may persist in immunosuppressed populations with significant morbidity and mortality. Based on clinical data published world-wide, UK blood safety guidance recommends the universal screening for HEV RNA of blood donors and donors of tissue, organs and stem cells. Read More

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October 2018
2 Reads

Characterization of the novel genotype avian hepatitis E viruses from outbreaks of hepatic rupture haemorrhage syndrome in different geographical regions of China.

Transbound Emerg Dis 2018 Aug 7. Epub 2018 Aug 7.

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, Shandong, China.

Since 2016, hepatic rupture haemorrhage syndrome (HRHS) has emerged in layer and broiler breeder hens in several provinces of China, and novel genotype avian hepatitis E viruses were detected from these chickens. To gain a better understanding of the genetic properties of the novel avian HEV strain, the capsid gene of four isolates from birds at four farms experiencing HRHS in different geographical regions were determined and compared with those of reported pathogenic and nonpathogenic avian HEV isolates as well as mammalian HEVs. Results showed that all those isolates share 80. Read More

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August 2018
2 Reads
2.94 Impact Factor

Hepatic rupture hemorrhage syndrome in chickens caused by a novel genotype avian hepatitis E virus.

Vet Microbiol 2018 Aug 26;222:91-97. Epub 2018 Jun 26.

College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China; Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China; Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, 61 Daizong Street, Tai'an City, Shandong Province, 271018, China. Electronic address:

Since 2016, severe outbreaks of hepatic rupture hemorrhage syndrome (HRHS) have emerged in chickens in several Chinese provinces and caused huge economic losses to the poultry industry, but the etiological characteristics and pathogenic potential of it has remained unclear. This study sequenced the partial helicase and capsid gene of the potentially novel avian hepatitis E virus (HEV) isolated from chickens with HRHS and tested the pathogenicity of it on SPF chicks, while the appearance of clinical signs, histopathological changes, viral distribution, viremia and viral shedding were monitored for 14 days post-infection (dpi). Analysis revealed that the HRHS related avian HEV belongs to a novel genotype, and infected chicks developed the typical symptoms of HRHS. Read More

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August 2018
5 Reads
2.51 Impact Factor

Hepatitis E Virus: A New Foodborne Zoonotic Concern.

Adv Food Nutr Res 2018 21;86:55-70. Epub 2018 May 21.

Jorvik Food and Environmental Virology, York, United Kingdom.

Hepatitis E virus (HEV) is an enteric nonenveloped single-stranded RNA virus. Among the mammalian lineages, four genotypes are associated to human infection: genogroups 1 and 2 infect only humans and are mainly found in developing countries, while genogroups 3 and 4 are zoonotic, being found in a variety of animal species including pigs, and are autochthonous in developed countries. HEV infection can result in liver damage and with genotypes 1 and 2 symptoms can be particularly severe in pregnant women, with a high lethality ratio. Read More

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Executive summary: Consensus document of the diagnosis, management and prevention of infection with the hepatitis E virus: Study Group for Viral Hepatitis (GEHEP) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC).

Enferm Infecc Microbiol Clin 2018 Jul 30. Epub 2018 Jul 30.

Hospital Universitario Álvaro Cunqueiro, Instituto de Investigación Sanitaria Galicia Sur, Vigo, Spain.

Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis in both developed and developing countries. This infectious disease has a high prevalence and incidence in Europe. HEV infection has a greater clinical impact in vulnerable populations, such as immunosuppressed patients, pregnant women and patients with underlying liver disease. Read More

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July 2018
1 Read

Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target.

FASEB J 2018 Aug 2:fj201800620R. Epub 2018 Aug 2.

Department of Gastroenterology and Hepatology, The Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

Hepatitis E virus (HEV) infection has emerged as a global health problem. However, no approved medication is available, and the infection biology remains largely elusive. Electron transport chain (ETC), a key component of the mitochondria, is the main site that produces ATP and reactive oxygen species (ROS). Read More

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August 2018
5 Reads

Evaluation of an antigen assay for diagnosing acute and chronic hepatitis E genotype 4 infection.

J Gastroenterol Hepatol 2018 Aug 2. Epub 2018 Aug 2.

Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing, China.

Background And Aim: Results obtained from different hepatitis E virus (HEV) tests are usually inconsistent. The detection of serum HEV antigen (Ag) has been suggested to be more sensitive for the diagnosis of genotypes 1 and 3 HEV.

Methods: We compared the diagnostic accuracies of serum HEV Ag and HEV RNA by using 202 serum samples from patients suspected acute viral hepatitis. Read More

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August 2018
9 Reads

Potent inhibition of hepatitis E virus release by a cyclic peptide inhibitor of the interaction between viral open reading frame 3 protein and host tumor susceptibility gene 101.

J Virol 2018 Aug 1. Epub 2018 Aug 1.

Virology Laboratory, Vaccine and Infectious Disease Research Centre

Hepatitis E virus (HEV) generally causes self-limiting acute viral hepatitis in normal individuals. It causes a more severe disease in immunocompromised persons and pregnant women. Due to the lack of an efficient cell culture system or animal model, life cycle of the virus is understudied, few antiviral targets are known and very few antiviral candidates have been identified against HEV infection. Read More

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August 2018
3 Reads

Risk factors and seroprevalence of hepatitis E evaluated in frozen-serum samples (2002-2003) of pregnant women compared with female blood donors in a Southern region of Brazil.

J Med Virol 2018 Jul 31. Epub 2018 Jul 31.

Department of Internal Medicine, Clinics Hospital, Federal University of Paraná, Curitiba, Brazil.

Hepatitis E has always been related to morbidity in pregnant women. Its epidemiology is not well understood in Brazil. Therefore, we tested sera from 209 pregnant women and 199 female blood donors, collected at a single center in Curitiba, Brazil. Read More

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July 2018
3 Reads