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Expert Rev Gastroenterol Hepatol 2019 Mar 24;13(3):205-211. Epub 2019 Jan 24.

a Department of Gastroenterology and Hepatology , Max Super Speciality Hospital , Ghaziabad , India.

Introduction: Hepatitis E virus (HEV) infection has distinct features, depending upon the genotype and geographical area. HEV genotypes 1 and 2 are endemic to various developing countries causing epidemics of acute viral hepatitis with human to human transmission. On the other hand, HEV genotypes 3 and 4 prevalent in developed countries commonly lead to subclinical infection and are transmitted zoonotically. Read More

Vector Borne Zoonotic Dis 2019 Feb 21. Epub 2019 Feb 21.

1 Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska.

Background: Due to their close relationship with the environment, Alaskans are at risk for zoonotic pathogen infection. One way to assess a population's disease burden is to determine the seroprevalence of pathogens of interest. The objective of this study was to determine the seroprevalence of 11 zoonotic pathogens in people living in Alaska. Read More

Emerg Infect Dis 2019 Mar;25(3):425-433

Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. Read More

Transbound Emerg Dis 2019 Feb 19. Epub 2019 Feb 19.

Dep. of Infectious Diseases, Inst. of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.

Hepatitis E virus (HEV) genotype 3 (HEV3) is distributed globally and infects both humans and animals, mainly domestic pigs and wild boars, which are the major reservoirs. In this study, the prevalence of HEV among Swedish pigs was investigated by HEV RNA analysis in 363 fecal samples from 3-month old piglets sampled twice (2013 and 2014) in 30 Swedish pig farms. Four different types of farms were investigated; organic, conventional closed (keeping the sow), satellites in a sow pool (conventional farms sharing sows), and conventional non-closed farms (purchasing gilts). Read More

MMW Fortschr Med 2019 Feb;161(3):61-63

Kliniken Ostallgäu-Kaufbeuren, Klinikum Kaufbeuren, Dr.-Gutermann-Straße 2, D-87600, Kaufbeuren, Deutschland.

Exp Clin Transplant 2019 Jan;17(Suppl 1):202-206

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

Objectives: The preferred modality for renal replacement therapy is renal transplantation. Marked improvements in early graft survival and long-term graft function have made renal transplantation a more cost-effective alternative to dialysis. The presence of liver disease in the posttransplant period adversely affects graft function and survival. Read More

Br J Haematol 2019 Feb 15. Epub 2019 Feb 15.

Department of Haematology, University College London Hospitals, London, UK.

Curr Hepatol Rep 2018 Sep 11;17(3):270-275. Epub 2018 Jul 11.

Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Purpose Of Review-: Without a specific biomarker the diagnosis of drug-induced liver injury (DILI) relies on exclusion of other causes of liver injury. This review examines the importance of testing for hepatitis C (HCV) and hepatitis E (HEV) in patients with suspected DILI.

Recent Findings-: Several national DILI registries have reported HCV and HEV infection in patients initially diagnosed with DILI. Read More

J Med Virol 2019 Feb 13. Epub 2019 Feb 13.

Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatitis B virus (HBV) vaccination was considered the most powerful tool for preventation of HBV transmission from mother to infant. In 1992 a universal HBV vaccination program for infants was lauched in China. The aim of this study was to investigate the HBV Surface antigen (HBsAg) varations in immunoprophylaxis-failed infants, vaccine free infant patients and adult chronic hepatitis B(CHB) patients (without nucleoside analog treatment). Read More

J Matern Fetal Neonatal Med 2019 Feb 13:1-111. Epub 2019 Feb 13.

a Department of Microbiology and Center of Infectious Disease , School of Basic Medical Sciences , Peking University Health Science Center , Beijing , China.

Background & Aims: The aim of this study was to investigate the positive rate of hepatitis E virus (HEV) infection and the possible adverse outcomes in pregnant women of Qinhuangdao, China.

Methods: Serum samples of 946 pregnant women were collected from July 2017 to October 2017 in Qinhuangdao First Hospital. All samples were tested for anti-HEV IgM and IgG antibodies by enzyme-linked immunosorbent assay (ELISA). Read More

Klin Mikrobiol Infekc Lek 2018 Sep;24(3):82-87

Division Hepatology, gastroenterology and liver transplantation of Department Internal medicine II, Faculty of Medicine, Slovak Medical University, FD Roosevelt Hospital, Banska Bystrica; Slovakia, e-mail:

Introduction: HEV infection is perceived as the cause of acute hepatitis in endemic areas. In addition, it may also manifest as a possible trigger of AD or acute-on-chronic liver failure (ACLF).

Objectives: To determine the prevalence of HEV infection as a trigger of AD/ACLF in patients admitted for decompensated ACLD (dACLD). Read More

J Infect 2019 Feb 7. Epub 2019 Feb 7.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. Electronic address:

Objectives: A case-control study was performed (2015-2017) to identify risk factors for acute hepatitis E in the Netherlands.

Methods: A questionnaire on potential sources of hepatitis E virus (HEV) exposure, health and socio-demographics was completed by 376 patients with acute hepatitis E, and 1534 controls matched for age, gender and region of residence.

Results: Traditional Dutch dry raw sausages of pork muscle meat, called "cervelaat", "snijworst", and "boerenmetworst" were reported by 72% of the patients, and 46% of controls (aOR 3. Read More

Acta Trop 2019 Feb 6;192:87-90. Epub 2019 Feb 6.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, People's Republic of China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province 130118, People's Republic of China; Jiangsu Co-innovation Center for the Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University College of Veterinary Medicine, Yangzhou, Jiangsu Province 225009, People's Republic of China. Electronic address:

Hepatitis E virus (HEV) and influenza A virus (IAV) are two important pathogens which can infect humans and various animals causing public health problems. In this study, the seroprevalence and risk factors associated with HEV and IAV infection in farmed wild boars were investigated in China. A total of 758 serum samples were collected from farmed wild boars between 2015 and 2016, and antibodies against HEV and IAV were examined by enzyme-linked immunosorbent assay (ELISA) using commercially available kits. Read More

Hepatology 2019 Feb 8. Epub 2019 Feb 8.

Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, New Hampshire, US.

The letter by Kamar et al., advancements in our understanding of chronic hepatitis E infection in solid organ transplant patients over time are highlighted. They cite the 2019 publication on the importance of fecal hepatitis E PCR in determining clearance of chronic infection. Read More

Sci Rep 2019 Feb 7;9(1):1616. Epub 2019 Feb 7.

The Catholic University Liver Research Center & WHO Collaborating Center of Viral Hepatitis, Department of Biomedicine & Health Sciences, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Virus-like particles (VLPs) possess great potential for organ-specific transport of therapeutic agents due to their central cavity surrounded by viral capsid proteins and similar tropism to their original viruses. The N-terminal truncated second open reading frame (Nt-ORF2) of the hepatotropic hepatitis E virus (HEV) forms VLPs via self-assembly. In the present study, we investigated whether HEV-LPs could deliver foreign genes specifically to the liver. Read More

Hepatology 2019 Feb 5. Epub 2019 Feb 5.

Biomedical Research Center, Northwest Minzu University, Lanzhou, China.

Recently, Drinane et al. presented the case of a kidney-pancreas transplant patient with chronic hepatitis E virus (HEV) infection who failed to clear HEV after two courses of ribavirin, and who thereafter eradicated HEV when ribavirin was combined to sofosbuvir. The authors claimed that sofosbuvir has a therapeutic activity against HEV. Read More

Ugeskr Laeger 2019 Jan;181(4)

In this case report, we present two Danish patients with hepatitis E virus (HEV) infection. In both cases, the route of transmission remained unclear. The infection led to typical symptoms in one case, whereas the other patient experienced neurological symptoms. Read More

Eur Rev Med Pharmacol Sci 2019 Jan;23(2):764-770

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Objective: Hepatitis E Virus (HEV) is probably the most common cause of acute hepatitis worldwide. It has been regarded for a long time as a disease limited to developing countries. Recently, the refinement of diagnostic techniques, on the one hand, and migratory flows, on the other hand, have also led to the identification of an increased number of HEV infections in industrialized countries. Read More

Sci Rep 2019 Feb 4;9(1):1143. Epub 2019 Feb 4.

Laboratorio de Referencia e Investigación en Hepatitis Víricas, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.

Hepatitis E virus (HEV) has emerged as a relevant pathogen for HIV-infected patients. However, there is scarce data on HEV infection in HIV/HCV-coinfected individuals with advanced fibrosis, which seems to increase the risk of HEV infection and worsen the prognosis of liver disease. We aimed to determine the prevalence of anti-HEV antibodies, acute hepatitis E, resolved hepatitis E, and exposure to HEV in HIV/HCV-coinfected patients and to evaluate associations with clinical and epidemiological characteristics. Read More

Virol J 2019 Feb 4;16(1):16. Epub 2019 Feb 4.

Department of Infectious Diseases, Zhejiang Provincial Center for Disease Control and Prevention, 3399 Binsheng Road, Binjiang District, Hangzhou, (310051), Zhejiang Province, China.

Background: To examine the epidemiological trends and changes of hepatitis E virus (HEV) infection and the potential risk factors for severe infection in the Zhejiang eastern coastal area of China.

Methods: We analyzed statutory hepatitis E cases notifications and inpatient data held by the national surveillance and hospital information systems in Wenzhou, Taizhou, Ningbo, and Zhoushan cities of the Zhejiang eastern coastal area of China.

Results: Nine thousand four hundred sixteen hepatitis E cases were reported from 2004 to 2017, with an average incidence of 2. Read More

Libyan J Med 2019 Dec;14(1):1564511

c College of Medicine , Princess Nourah bint Abdulrahman University , Riyadh , Saudi Arabia.

Vector-borne diseases are responsible for more than 20% of the infectious diseases worldwide. The prevalence of arboviruses transmit diseases to humans in Sudan has not been investigated. Mosquito-borne viral diseases increase globally incidence, including the Sudan. Read More

Clin Microbiol Infect 2019 Jan 31. Epub 2019 Jan 31.

Institute of Immunization and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China; Xiamen INNOVAX Biotech CO.Ltd, Xiamen, China; Institute of Immunization and Prevention, Changshan Center for Disease Control and Prevention, Quzhou, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, Fujian, China. Electronic address:

Objectives: This study aimed to evaluate the immunogenicity and safety of a hepatitis E vaccine using an accelerated vaccination schedule (vaccine doses at 0, 7, and 21 days).

Methods: A total of 126 participants aged≥18 were randomly assigned to receive the HEV vaccine in either the accelerated group (0, 7 and 21 days) or the routine group (0, 1 and 6 months). Serology samples were obtained at 0, 21, 28, and 51 days and 7 months in the accelerated group or 0, 1, 2 and 7 months in the routine group after the first vaccine injection. Read More

Acta Vet Scand 2019 01 31;61(1). Epub 2019 Jan 31.

Department of Anatomy and Physiology, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Tilzes str. 18, Kaunas, Lithuania.

Following publication of the original article [1], we have been notified of a typing error in the "Discussion" section. Read More

J Gen Virol 2019 Jan 31. Epub 2019 Jan 31.

2​Savitribai Phule Pune University, Ganeshkhind, Pune 411 007, India.

Hepatitis E virus (HEV) induces interferons and regulates the induction of interferon-stimulated genes (ISGs) in the host cell. HEV infection has been shown to promote the expression of different ISGs, such as ISG15, IFIT1, MX1, RSAD2/Viperin and CxCL10, in cell culture and animal models. Interferon-induced protein with tetratricopeptide repeat 1 (IFIT1) is an ISG-encoded protein that inhibits the translation of viral RNA, having 5'-triphosphate or the mRNA lacking 2'-O-methylation on the 5'cap. Read More

Transfusion 2019 Jan 31. Epub 2019 Jan 31.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Background: Hepatitis E virus (HEV) can inapparently infect blood donors. To assess transfusion transmission of HEV in the United States, which has not been documented, a donor-recipient repository was evaluated.

Study Design And Methods: To identify donations that contained HEV RNA and were linked to patient-recipients with antibody evidence of HEV exposure, we assayed samples from the Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient repository that represents 13,201 linked donations and 3384 transfused patients. Read More

Ter Arkh 2018 Feb;90(2):102-104

Kirov Infectious Clinical Hospital, Kirov, Russia.

The article presents an analysis of the clinical case of superinfection of autochthonous acute hepatitis E against the background of HBV-cirrhosis of the liver. HEV infection was diagnosed in a 39 year old man who did not travel outside the region and the country for a long time and used unboiled water. The peculiarity of the disease in the non-endemic region was: a severe course of hepatitis E against the background of HBV etiology, with the development of the clinic for acute hepatic insufficiency and encephalopathy, the presence of severe cytolysis syndrome, cholestasis, hepatic-cell insufficiency and prolonged convalescence. Read More

Microbiol Resour Announc 2019 Jan 24;8(4). Epub 2019 Jan 24.

Clinical Laboratory Center, Taizhou People's Hospital, Taizhou, Jiangsu, China.

Using viral metagenomics, we analyzed the virome of a blood sample from a hepatitis E patient. We identified viral sequences showing significant similarity to human pegivirus (HPgV), anellovirus, and hepatitis E virus. The near-complete genome of a genotype 3 HPgV strain was acquired and characterized. Read More

J Virol 2019 Jan 30. Epub 2019 Jan 30.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China

Hepatitis E virus (HEV) is zoonotic and a major cause of acute viral hepatitis worldwide. Recently, we identified a novel HEV genotype 8 (HEV8) in Bactrian camels in Xinjiang, China. However, the epidemiology, pathogenicity and zoonotic potential of HEV8 are unclear. Read More

Haemophilia 2019 Jan 29. Epub 2019 Jan 29.

Department of Internal Medicine I, University Hospital of Bonn, Bonn, Germany.

Klin Lab Diagn 2018 ;63(5):310-314

The Federal State Budget Educational Institution of Higher Education "I.I. Mechnikov North-Western State Medical University" of Minzdrav of Russia, 191015, St. Petersburg, Russia.

The purpose of the study was to determine the duration of antibody response against hepatitis E virus (anti-HEV). Veterans of the war in Afghanistan who were in this endemic region in the late 1970s and early 1980s were tested for anti-HEV. On average, 20 years after the end of military service in Afghanistan, the rate of seropositivity was 30. Read More

Transfus Med 2019 Jan 28. Epub 2019 Jan 28.

NHS Blood and Transplant/Public Health England Epidemiology Unit, NHS Blood and Transplant, London, UK.

Aims/objectives: Here, we describe the annual review of the UK blood services' infection surveillance schemes for 2017 (www.gov.uk/government/publications/safe-supplies-annual-review). Read More

Mikrobiyol Bul 2019 Jan;53(1):43-52

Harran University Veterinary of Veterinary Medicine, Department of Food Hygiene and Technology, Şanlıurfa, Turkey.

Hepatitis E virus (HEV) is one of the major foodborne viral pathogens transmitted through the fecal-oral route. Four genotypes of HEV are known to infect humans and it is reported that different types of HEV are active in zoonotic transitions. It is known that the HEV genotype 1 and HEV genotype 2 infections are generally acute and the HEV genotype 3 infections are chronic. Read More

Viruses 2019 Jan 20;11(1). Epub 2019 Jan 20.

Unité des Virus Emergents (UVE), Aix-Marseille Université, IRD 190, INSERM 1207, IHU Méditerranée Infection, 13005 Marseille, France.

Although Hepatitis E is increasingly described as a major cause of liver disease in industrialized countries, the epidemiology is far from being fully elucidated. We provide here a comprehensive review of documented clusters of cases, and of serological studies conducted in populations with distinct types of exposure. Seroprevalence rates range from <5% to >50% depending on the countries and the groups of population. Read More

Transpl Infect Dis 2019 Jan 21:e13050. Epub 2019 Jan 21.

Department of Nephrology and Organ Transplantation, CHU Rangueil, Toulouse, France.

Transbound Emerg Dis 2019 Jan 19. Epub 2019 Jan 19.

Division of HIV/AIDS and Sex-Transmitted Virus Vaccines, National Institutes for Food and Drug Control, Beijing, China.

Hepatitis E virus (HEV) was first detected in rabbits in the year 2009. Rabbit HEV is now known to be widely prevalent in rabbits and tentatively assigned into genotype 3 (HEV-3) as subgenotype-3ra (HEV-3ra). However, its role in human infection remains undetermined. Read More

J Viral Hepat 2019 Jan 19. Epub 2019 Jan 19.

Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Cordoba, Spain.

Hepatitis E virus (HEV) represents a major health problem worldwide. As the course of HEV cases is often subclinical, asymptomatic infections could represent an important source of viral spread and infection via routes such as blood donations. Before universal screening for HEV in blood donations can be implemented, studies evaluating the incidence of infection are needed to establish the potential risk of viral transmission. Read More

J Infect 2019 Jan 17. Epub 2019 Jan 17.

Inserm UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; Laboratory of Virology, CHU Purpan, Toulouse, France; Université Paul Sabatier, Toulouse, France. Electronic address:

Objectives: Hepatitis E virus genotype 3 (HEV3) is responsible for acute and chronic liver disease in solid organ transplant (SOT) recipients. HEV was recently found in the urine of some acutely and chronically genotype 4-infected patients.

Methods: We examined the urinary excretion of HEV3 by 24 consecutive SOT recipients at the acute phase of HEV hepatitis and characterized the excreted virus. Read More

J Clin Virol 2019 Jan 11;112:10-14. Epub 2019 Jan 11.

CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, National Reference Center for Hepatitis E, F-31300, France; INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, F-31300, France.

Background: Several unautomated anti-HEV diagnostic tests are presently available.

Objective: We have evaluated the performance of the new automated VIDAS® ANTI-HEV IgM and IgG assays.

Study Design: We assessed the reproducibility and cross-reactivity of both VIDAS assays and the analytical sensitivity and linearity of the VIDAS IgG assay. Read More

Antiviral Res 2019 Mar 14;163:34-49. Epub 2019 Jan 14.

Ruhr-University Bochum, Faculty of Medicine, Department of Molecular and Medical Virology, Bochum, Germany. Electronic address:

Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically-transmitted viral hepatitis worldwide. Increasing numbers of HEV infections, together with no available specific anti-HEV treatment, contributes to the pathogen's major health burden. A robust cell culture system is required for virologic studies and the development of new antiviral drugs. Read More

Viruses 2019 Jan 15;11(1). Epub 2019 Jan 15.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China.

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. Current methods for evaluating the neutralizing activity of HEV-specific antibodies include immunofluorescence focus assays (IFAs) and real-time PCR, which are insensitive and operationally complicated. Here, we developed a high-throughput neutralization assay by measuring secreted pORF2 levels using an HEV antigen enzyme-linked immunosorbent assay (ELISA) kit based on the highly replicating HEV genotype (gt) 3 strain Kernow. Read More

PLoS One 2019 16;14(1):e0210373. Epub 2019 Jan 16.

Department of Cardiac Surgery, University of Leipzig-Leipzig Heart Center, Leipzig, Germany.

Background: Hypercholesterolaemia is common in patients after cardiac transplantation. Monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) reduce low-density lipoprotein (LDL) cholesterol levels and subsequently the risk of cardiovascular events in patients with dyslipidaemia. There are no published data on the effect of this medication class on cholesterol levels in patients after cardiac transplantation. Read More

J Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

Department of Medicine, Nova Scotia Health Authority, Canada.

Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan and the United States with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat hepatitis E virus with a considerably divergent genomic sequence compared to other rat HEV strains. Read More

Infect Dis Poverty 2019 Jan 16;8(1). Epub 2019 Jan 16.

School of Medicine, USP, São Paulo, SP, Brazil.

Background: Hepatitis E virus (HEV) is a member of the Hepeviridae family; it has four main genotypes and one serotype. While genotypes 1 and 2 cause epidemic hepatitis and are transmitted via water and the fecal-oral route, genotypes 3 and 4 are zoonotic. In the various seroprevalence studies of hepatitis E in Brazil, the numbers reported vary widely and are difficult to interpret. Read More

Vet Microbiol 2019 Feb 4;229:168-175. Epub 2019 Jan 4.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China; Scientific Observing and Experimental Station of Veterinary Pharmacology and Diagnostic Technology, Ministry of Agriculture, Yangling, Shaanxi, China. Electronic address:

Hepatitis E virus (HEV) is a zoonotic virus that is capable of causing cross-species infection. Rabbits can be experimentally infected with human- and swine-derived HEV-4 in the species Orthohepevirus A, and avian-derived HEV-3 in the species Orthohepevirus B suggesting rabbits can serve as an animal model for zoonotic HEV infection study. However, these studies show that the infectivity of swine HEV isolates in rabbits is not consistent. Read More

Int J Infect Dis 2019 Jan 9;80:66-72. Epub 2019 Jan 9.

Istituto Zooprofilattico Sperimentale della Sicilia, Palermo, Italy.

Objectives: Enteric viruses are responsible for foodborne and waterborne infections affecting a large number of people. Data on food and water viral contamination in the south of Italy (Sicily) are scarce and fragmentary. The aim of this study was to evaluate the presence of viral contamination in food, water samples, and surface swabs collected in Sicily METHODS: The survey was conducted on 108 shellfish, 23 water samples (seawater, pipe water, and torrent water), 52 vegetables, one peach and 17 berries, 11 gastronomic preparations containing fish products and/or raw vegetables, and 28 surface swabs. Read More

Microbiol Resour Announc 2019 Jan 3;8(1). Epub 2019 Jan 3.

Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany.

Hepatitis E virus genotype 1 (HEV-1) is associated with large epidemics. Notably, HEV subtype 1e (HEV-1e) has caused HEV outbreaks in sub-Saharan Africa. We report here the second full-length genome sequence of an HEV-1e strain (NG/17-0503) from a recent outbreak in Nigeria in 2017. Read More

J Med Virol 2019 Jan 13. Epub 2019 Jan 13.

Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases, Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Hepatitis E virus (HEV) could induce chronic hepatitis and liver failure with high mortality through unknown mechanisms. The previous study showed that the HEV open reading frames 3 (ORF3) could inhibit macrophages inflammatory response. Impaired macrophages phagocytosis was also found in patients infected with HEV and its nucleic acids could be detected in macrophages. Read More

J Viral Hepat 2019 Jan 12. Epub 2019 Jan 12.

Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, Maryland.

Hepatitis E virus (HEV) has traditionally been associated with an acute, self-limiting hepatitis and is not known to have any chronic sequelae. HEV genotypes 1 and 2, which are human pathogens, have been associated with this self-limiting presentation, in both sporadic and epidemic settings. HEV genotype 3, which is zoonotically transmitted, is increasingly being reported as a cause of chronic infection in immunocompromised patients. Read More

Int J Infect Dis 2019 Jan 10;80:62-63. Epub 2019 Jan 10.

Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes, Evolution, Phylogeny and Infection (MEΦI), Institut Hospitalo-Universitaire (IHU) - Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Assistance Publique - Hôpitaux de Marseille (AP-HM), Centre Hospitalo-Universitaire Timone, Service d'Hépatologie-Gastrologie-Entérologie, 264 rue Saint-Pierre, 13385 Marseille Cedex 05, France.

Med Sci (Paris) 2018 Dec 9;34(12):1071-1078. Epub 2019 Jan 9.

Université de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR8204-CIIL- Center for Infection and Immunity of Lille 1, rue du Professeur Calmette, F-59000 Lille, France.

The first cause of acute hepatitis in the world is due to the hepatitis E virus (HEV). This infection has long been considered as a problem only affecting developing countries. However, since the identification of zoonotic forms at the end of the last century, it has become clear that this infection also affects industrialized countries. Read More