2,724 results match your criteria Hepatitis D


Clinical outcomes in patients with hepatitis D, cirrhosis and persistent hepatitis B virus replication, and receiving long-term tenofovir or entecavir.

Aliment Pharmacol Ther 2019 Feb 21. Epub 2019 Feb 21.

Infectious Diseases, Campania University "Luigi Vanvitelli", Naples, Italy.

Background: Suppression of hepatitis B virus (HBV) replication with nucles(t)ide analogues should be considered for patients with chronic hepatitis D virus (HDV) infection and ongoing HBV replication.

Aim: To verify the clinical outcome after long-term entecavir or tenofovir treatment in patients with advanced fibrosis/cirrhosis, ineligible to peg-interferon therapy.

Methods: Patients were prospectively followed-up at 3-6 month intervals; measured outcomes were decompensation, hepatocellular carcinoma (HCC), liver transplant and liver related death. Read More

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http://dx.doi.org/10.1111/apt.15188DOI Listing
February 2019

New treatment option for delta virus: is a cure in sight?

Authors:
Cihan Yurdaydin

J Viral Hepat 2019 Feb 16. Epub 2019 Feb 16.

Department of Gastroenterology, Ankara University Medical School, Cebeci Tıp Fakültesi Hastanesi, Dikimevi, 06100, Ankara, Turkey.

Current treatment of chronic hepatitis D viral infection with interferons is poorly tolerated and effective only in a minority of patients. Despite Delta virus causing the most severe form of chronic viral hepatitis no other treatments are available. After many years of inactivity there is now hope for new treatment approaches for Delta virus and some are likely to enter clinical practice in the near future. Read More

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http://doi.wiley.com/10.1111/jvh.13081
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http://dx.doi.org/10.1111/jvh.13081DOI Listing
February 2019
3 Reads

Mutations in Hepatitis D Virus Allow it to Escape Detection by CD8+ T Cells and Evolve at the Population Level.

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Department of Medicine II, University Hospital Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

Background & Aims: Hepatitis D virus (HDV) super-infection in patients with hepatitis B virus (HBV) is associated with rapid progression to liver cirrhosis and hepatocellular carcinoma. Treatment options are limited, and no vaccine is available. Although HDV-specific CD8+ T cells are thought to control the virus, little is known about which HDV epitopes are targeted by virus-specific CD8+ T cells or why these cells ultimately fail to control the infection. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.003DOI Listing
February 2019
1 Read
16.716 Impact Factor

Epidemiology of viral hepatitis in the Maghreb.

Tunis Med 2018 Oct-Nov;96(10-11):606-619

Introduction: Viral hepatitis represents a serious public health problem in the world especially in the Maghreb where the prevalence of the 5 viruses A, B, C, D, and E remains high and varies from one Maghreb country to another, there is few published studies on these infections in our Maghreb countries.

Method Of Study: Our work is a review of the literature about prevalence, the most common mode of transmission, and the most exposed population for these viruses in the Maghreb countries through published studies between 2011 and 2017.

Result: It has been found that the Maghreb countries are endemic for the five viruses with variable prevalence from one country to another, with sometimes heterogeneous data in the same country. Read More

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February 2019
1 Read

Hepatitis Delta Prevalence in South America: A Systematic Review and Meta-Analysis.

Rev Soc Bras Med Trop 2019 Jan 24;52:e20180289. Epub 2019 Jan 24.

Diretoria de Pesquisa e Desenvolvimento. Fundação Ezequiel Dias, Belo Horizonte, MG, Brasil.

Hepatitis delta virus (HDV) has been associated with acute or chronic hepatitis in Latin America, but there is no prevalence study covering South American countries. This meta-analysis aimed to estimate anti-HDV prevalence through a systematic review of published articles in English, Portuguese and Spanish until December 2017. Searches were conducted in Health Virtual Library, Capes, Lilacs, PubMed, and SciELO, according to defined criteria regarding participant selection and geographical setting. Read More

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http://dx.doi.org/10.1590/0037-8682-0289-2018DOI Listing
January 2019
2 Reads

Hepatitis D - how is the fight against this foe going?

Expert Rev Clin Pharmacol 2019 Mar 6;12(3):169-171. Epub 2019 Feb 6.

a CRC "A. M. and A. Migliavacca" Center for the Study of Liver Disease, Division of Gastroenterology and Hepatology , Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano , Milan , Italy.

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1577135DOI Listing
March 2019
12 Reads

Non-F HBV/HDV-3 coinfection is associated with severe liver disease in Western Brazilian Amazon.

J Med Virol 2019 Jan 29. Epub 2019 Jan 29.

Institut National de la Santé et de la Recherche Medicale, INSERM U1052, Lyon, France.

The clinical outcome of hepatitis B virus (HBV) infection may be related to host and viral genetic factors, as well as to the type of infection (monoinfection and coinfection). To analyze the distribution/combination of HBV/hepatitis D virus (HDV) genotypes and the associated clinical characteristics, 409 serum samples from patients with chronic HBV (94 of them coinfected by HDV) followed at the Viral Hepatitis Referral Center of Rio Branco, Brazil were enrolled. HBV DNA and HDV RNA were amplified, respectively, by polymerase chain reaction (PCR) and nested PCR using specific primers in the PreC/C region and the S gene, and by reverse-transcription PCR and seminested PCR using specific primers in the delta antigen region and sequenced. Read More

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http://doi.wiley.com/10.1002/jmv.25411
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http://dx.doi.org/10.1002/jmv.25411DOI Listing
January 2019
3 Reads

The balance of type 1 and type 2 immune responses in the contexts of hepatitis B infection and hepatitis D infection.

J Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD.

Background: Hepatitis delta virus (HDV) infection is the most rapidly progressive chronic viral hepatitis. Little is understood about the immune responses to HDV.

Aim: To characterize the systemic immune environments of hepatitis B virus (HBV) and HDV patients at various disease stages. Read More

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http://dx.doi.org/10.1111/jgh.14617DOI Listing
January 2019
2 Reads

Hepatitis D Virus-specific CD8 T Cells Have a Memory-like Phenotype Associated With Viral Immune Escape in Patients With Chronic Hepatitis D Virus Infection.

Gastroenterology 2019 Jan 18. Epub 2019 Jan 18.

Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, MD, USA. Electronic address:

Background & Aim: Hepatitis D virus (HDV) superinfection of patients with chronic HBV infection results in rapid progression to liver cirrhosis. Little is known about HDV-specific T cells and how they contribute to the anti-virus immune response and liver disease pathogenesis.

Methods: We isolated peripheral blood mononuclear cells from 28 patients with chronic HDV and HBV infection, identified HDV-specific CD8 T-cell epitopes and characterized HDV-specific CD8 T cells. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.01.035DOI Listing
January 2019
3 Reads

Hepatitis D virus infection, cirrhosis and hepatocellular carcinoma in The Gambia.

J Viral Hepat 2019 Jan 20. Epub 2019 Jan 20.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Hepatocellular carcinoma (HCC) incidence is high in The Gambia, and hepatitis B virus (HBV) infection is the main cause. People coinfected with HBV and hepatitis D virus (HDV) have an even greater risk of HCC and cirrhosis. Using a new HDV quantitative microarray antibody capture (Q-MAC) assay, we evaluated the association between HDV infection and HCC or cirrhosis among participants in The Gambia Liver Cancer Study. Read More

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http://doi.wiley.com/10.1111/jvh.13065
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http://dx.doi.org/10.1111/jvh.13065DOI Listing
January 2019
5 Reads
3.909 Impact Factor

Towards curative therapy of chronic viral hepatitis.

Z Gastroenterol 2019 Jan 14;57(1):61-73. Epub 2019 Jan 14.

Institut für Virologie, Technische Universität München.

Persistent infection with hepatitis viruses is a major medical burden that unfortunately is often ignored in the general public. This results in a massive under-diagnosis of these infections. According to the world health organization, the number of people dying every year from the consequence of hepatitis virus infection has surpassed the death rate caused by malaria and HIV and is equivalent to the one of tuberculosis. Read More

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http://dx.doi.org/10.1055/a-0824-1576DOI Listing
January 2019
7 Reads

Prevalence of Hepatitis B and Hepatitis D Virus Infections in the United States, 2011-2016.

Clin Infect Dis 2019 Jan 3. Epub 2019 Jan 3.

Dept. of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

In the U.S. household population aged 18 years (2011-2016), prevalence of hepatitis B surface antigen (HBsAg) was 0. Read More

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http://dx.doi.org/10.1093/cid/ciz001DOI Listing
January 2019
1 Read

Hepatitis B, C, and D virus and human T-cell leukemia virus types 1 and 2 infections and correlates among men who have sex with men in Ouagadougou, Burkina Faso.

Virol J 2018 12 29;15(1):194. Epub 2018 Dec 29.

University Ouaga1 Joseph Ki-Zerbo, Ouagadougou, Burkina Faso.

Background: Men who have sex with men (MSM) are considered to be at significant risk for sexually transmitted infections (STI) and bloodborne viruses including viral hepatitis types B, C, and D (HBV, HCV, and HDV) and human T-cell leukemia virus types 1 and 2 (HTLV 1&2). This study aimed to assess the seroprevalence and correlates of HBV, HCV, HDV, and HTLV 1&2 antibodies among MSM in Ouagadougou, Burkina Faso.

Methods: We conducted a cross-sectional survey to assess the biological and behavourial characteristics among MSM in Ouagadougou from January to April 2013. Read More

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http://dx.doi.org/10.1186/s12985-018-1110-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311018PMC
December 2018
3 Reads

INASL Guidelines on Management of Hepatitis B Virus Infection in Patients receiving Chemotherapy, Biologicals, Immunosupressants, or Corticosteroids.

J Clin Exp Hepatol 2018 Dec 26;8(4):403-431. Epub 2018 Jun 26.

Hepatology & Liver Transplant (Medicine), Fortis Escorts Liver & Digestive Diseases Institute (FELDI), Fortis Escorts Hospital, Delhi, India.

Hepatitis B Virus (HBV) reactivation in patients receiving chemotherapy, biologicals, immunosupressants, or corticosteroids is emerging to be an important cause of morbidity and mortality in patients with current or prior exposure to HBV infection. These patients suffer a dual onslaught of illness: one from the primary disease for which they are receiving the culprit drug that led to HBV reactivation, and the other from HBV reactivation itself. The HBV reactivation not only leads to a compromised liver function, which may culminate into hepatic failure; it also adversely impacts the treatment outcome of the primary illness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09736883183009
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http://dx.doi.org/10.1016/j.jceh.2018.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286881PMC
December 2018
19 Reads

Hepatitis D prevalence: problems with extrapolation to global population estimates.

Gut 2018 Dec 19. Epub 2018 Dec 19.

Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1136/gutjnl-2018-317874DOI Listing
December 2018
2 Reads

A Divergent Hepatitis D-Like Agent in Birds.

Viruses 2018 12 17;10(12). Epub 2018 Dec 17.

WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.

Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. Read More

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http://dx.doi.org/10.3390/v10120720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315422PMC
December 2018
1 Read

Automated nucleic acid isolation methods for HDV viral load quantification can lead to viral load underestimation.

Antivir Ther 2018 Dec 5. Epub 2018 Dec 5.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

Background: Hepatitis D virus (HDV) infection is a cause of severe liver disease. Diagnosis and monitoring of HDV RNA are important to patient management. Since 2012 a WHO standard for HDV RNA quantification is available, however, the impact of RNA extraction methods on HDV viral load quantification has never been evaluated. Read More

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https://www.intmedpress.com/journals/avt/abstract.cfm?id=328
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http://dx.doi.org/10.3851/IMP3281DOI Listing
December 2018
12 Reads

Epidemiology and clinical management of HIV-HBV coinfected patients in a large AIDS Reference Center in Belgium.

Acta Clin Belg 2018 Dec 4:1-6. Epub 2018 Dec 4.

b Department of Infectious Diseases , Saint-Pierre University Hospital , Brussels ,
 Belgium.

Objectives: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are both worldwide health concerns with similar routes of transmission and no curative treatment to date. Coinfection is associated with increased morbidity and mortality. We aim to provide epidemiological data about HIV-HBV coinfected patients and asses if management of patients following European recommendation (EACS) was achieved in a large AIDS Reference Center in Belgium. Read More

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http://dx.doi.org/10.1080/17843286.2018.1554292DOI Listing
December 2018
1 Read

[Hepatitis delta virus replication and the role of the small hepatitis delta protein S-HDAg].

Med Sci (Paris) 2018 Oct 19;34(10):833-841. Epub 2018 Nov 19.

Inserm, U1052 - UMR CNRS 5286, Centre de recherche en cancérologie de Lyon, Lyon, France - Laboratoire de microbiologie clinique, groupe des Hôpitaux universitaires de Paris-Seine Saint Denis, UFR santé médecine, biologie humaine, université Paris 13, Bobigny, France.

Hepatitis delta virus (HDV) is a mammalian defective virus. Its genome is a small single-stranded circular RNA of approximately 1,680 nucleotides. To spread, HDV relies on hepatitis B virus envelope proteins that are needed for viral particle assembly and egress. Read More

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https://www.medecinesciences.org/10.1051/medsci/2018209
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http://dx.doi.org/10.1051/medsci/2018209DOI Listing
October 2018
20 Reads

HDV evolution-will viral resistance be an issue in HDV infection?

Curr Opin Virol 2018 Oct 8;32:100-107. Epub 2018 Nov 8.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain; Liver Pathology Unit, Departments of Biochemistry and Microbiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona (UAB), 08035 Barcelona, Spain. Electronic address:

Hepatitis D virus (HDV) is a hepatotropic subviral infectious agent, obligate satellite of the Hepatitis B virus (HBV) and is highly related to viroids. HDV affects around 5% of the 257 million chronic HBV-carriers worldwide, leading to the most severe form of chronic viral hepatitis. Interferon alpha is the only approved treatment for chronic hepatitis D, albeit with low response rates (around 20%-30%). Read More

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http://dx.doi.org/10.1016/j.coviro.2018.10.003DOI Listing
October 2018
1 Read

Delta hepatitis in resolved hepatitis B.

Eur J Gastroenterol Hepatol 2018 12;30(12):1528

Unit of Gastroenterology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1097/MEG.0000000000001253DOI Listing
December 2018
10 Reads

The influence of ethnicity on disease outcome in patients with chronic hepatitis B infection.

J Med Virol 2019 Apr 28;91(4):623-629. Epub 2018 Nov 28.

School of Nutrition and Translational Research in Metabolism, University Maastricht, Maastricht, The Netherlands.

Since the cultural diversity in Western Europe is growing, this study assessed whether foreign-born chronic hepatitis B (CHB) patients have more cirrhosis than Dutch- or Belgian-born patients, with a main focus on the Turkish population. Baseline characteristics (eg, socioeconomic status [SES]), biological characteristics, and disease outcome (eg, cirrhosis) were collected for all patients. Between December 2009 and January 2015, 269 CHB patients participated from the outpatient departments of three hospitals in the Netherlands, Belgium, and Turkey. Read More

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http://doi.wiley.com/10.1002/jmv.25353
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http://dx.doi.org/10.1002/jmv.25353DOI Listing
April 2019
2 Reads

Anti-HDV seroprevalance among patients with previous HBV infection.

North Clin Istanb 2018 21;5(2):132-138. Epub 2018 May 21.

Department of Internal Medicine, Faculty of Medicine, Firat University, Division of Gastroenterology, Elazig, Turkey.

Objective: This prospective study aimed to determine the prevalence of anti-HDV seropositivity among subjects who had previous hepatitis B virus (HBV) infection.

Methods: Subjects who were admitted to the gastroenterology inpatient clinic of our hospital between August 2016 and July 2017 were screened for previous HBV infection. The subjects who had HBV serology compatible with resolved HBV infection were recruited in the study, and the seroprevalance of anti-HDV was studied. Read More

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http://www.kuzeyklinikleri.com/jvi.aspx?pdir=nci&plng=en
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http://dx.doi.org/10.14744/nci.2018.01328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191552PMC
May 2018
25 Reads

Devil hepatitis D: an orphan disease or largely underdiagnosed?

Gut 2018 Oct 27. Epub 2018 Oct 27.

Divisions of Gastroenterology and Hepatology of Clinical Pathology, University Hospital of Geneva, Geneva, Switzerland.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-317403
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http://dx.doi.org/10.1136/gutjnl-2018-317403DOI Listing
October 2018
9 Reads

The Epidemiology of Hepatitis D Virus in North Africa: A Systematic Review and Meta-Analysis.

ScientificWorldJournal 2018 26;2018:9312650. Epub 2018 Sep 26.

Department of Planning, Faculty of Engineering, University of Tripoli, CC 82668, Tripoli, Libya.

Background: Hepatitis D virus (HDV) infection has been considered a serious neglected pandemic, particularly in developing countries. The virus causes a more severe disease than mono infection with hepatitis B virus (HBV). The epidemiology of HDV is not well documented in North Africa, which is known to be endemic for HBV. Read More

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https://www.hindawi.com/journals/tswj/2018/9312650/
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http://dx.doi.org/10.1155/2018/9312650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178169PMC
January 2019
13 Reads

Pathogenesis of and New Therapies for Hepatitis D.

Gastroenterology 2019 01 18;156(2):461-476.e1. Epub 2018 Oct 18.

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California. Electronic address:

Hepatitis delta virus (HDV) infection of humans was first reported in 1977, and now it is now estimated that 15-20 million people are infected worldwide. Infection with HDV can be an acute or chronic process that occurs only in patients with an hepatitis B virus infection. Chronic HDV infection commonly results in the most rapidly progressive form of viral hepatitis; it is the chronic viral infection that is most likely to lead to cirrhosis, and it is associated with an increased risk of hepatocellular carcinoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183516
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http://dx.doi.org/10.1053/j.gastro.2018.09.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340762PMC
January 2019
14 Reads

Epidemiology of hepatitis B, C and D in Malawi: systematic review.

BMC Infect Dis 2018 Oct 12;18(1):516. Epub 2018 Oct 12.

Malawi Liverpool Wellcome Trust Clinical Research Programme, Chichiri 3, PO Box 30096, Blantyre, Malawi.

Background: Viral hepatitis is an important public health issue in sub-Saharan Africa. Due to rising mortality from cirrhosis and hepatocellular carcinoma and limited implementation of screening and treatment programmes, it has been characterised as a neglected tropical disease. Synthesis of the existing evidence on the epidemiology of viral hepatitis B, C and D in Malawi is required to inform policy and identify research gaps. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3428-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186098PMC
October 2018
2 Reads

Multiple chronic parasitic infections in an immunocompetent immigrant: a challenge for healthcare management.

Infez Med 2018 Sep;26(3):276-279

Dipartimento di Biotecnologie Mediche, Università di Siena, Siena, Italy; UOC Malattie Infettive Universitarie, AOUS, Siena, Italy.

The case reports multiple helmintiasis and chronic hepatitis caused by hepatitis B virus (HBV)/hepatitis D virus (HDV) in an immunocompetent immigrant male. It highlights the importance of early diagnosis and treatment of neglected infectious diseases in low endemic areas, besides difficulties that Western countries encounter in responding to immigrants' health needs. Read More

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September 2018
4 Reads

Transmission of Hepatitis B and D Viruses in an African Rural Community.

mSystems 2018 Sep-Oct;3(5). Epub 2018 Sep 18.

Swiss Tropical and Public Health Institute, Molecular Immunology, Basel, Switzerland.

According to the World Health Organization (WHO), an estimated 257 million people worldwide are chronically infected with hepatitis B virus (HBV), with approximately 15 million of them being coinfected with hepatitis D virus (HDV). To investigate the prevalence and transmission of HBV and HDV within the general population of a rural village in Cameroon, we analyzed serum samples from most (401/448) of the villagers. HBV surface antigen (HBsAg) was detected in 54 (13. Read More

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http://dx.doi.org/10.1128/mSystems.00120-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143728PMC
September 2018
3 Reads

Epidemiology of viral hepatitis in Somalia: Systematic review and meta-analysis study.

World J Gastroenterol 2018 Sep;24(34):3927-3957

Center For the study of the Liver, Department of Hospital Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow 117198, Russia.

Aim: To provide a clear understanding of viral hepatitis epidemiology and their clinical burdens in Somalia.

Methods: A systematic review and meta-analysis was conducted as Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search of published studies on viral hepatitis was performed from 1977-2016 in PubMed, Google Scholar, Science Direct, World Health Organization African and the Africa Journals Online databases, as well as on the Ministry of Health website. Read More

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http://dx.doi.org/10.3748/wjg.v24.i34.3927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141335PMC
September 2018
6 Reads

Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis.

Gut 2018 Sep 18. Epub 2018 Sep 18.

Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. Read More

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2018-316601
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http://dx.doi.org/10.1136/gutjnl-2018-316601DOI Listing
September 2018
5 Reads
14.660 Impact Factor

REP 2139: Antiviral Mechanisms and Applications in Achieving Functional Control of HBV and HDV Infection.

Authors:
Andrew Vaillant

ACS Infect Dis 2018 Oct 5. Epub 2018 Oct 5.

Replicor Inc. , 6100 Royalmount Avenue , Montreal , Quebec H4P 2R2 , Canada.

Nucleic acid polymers (NAPs) are broad spectrum antiviral agents whose antiviral activity in hepatitis B virus (HBV) infection is derived from their ability to block the release of the hepatitis B virus surface antigen (HBsAg). This pharmacological activity blocks replenishment of HBsAg in the circulation, allowing host mediated clearance. This effect has important clinical significance as the clearance of circulating HBsAg dramatically potentiates the ability of immunotherapies to restore functional control of HBV infection which persists after antiviral therapy is removed. Read More

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http://pubs.acs.org/doi/10.1021/acsinfecdis.8b00156
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http://dx.doi.org/10.1021/acsinfecdis.8b00156DOI Listing
October 2018
1 Read

Screening for hepatitis D and PEG-Interferon over Tenofovir enhance general hepatitis control efforts in Brazil.

PLoS One 2018 7;13(9):e0203831. Epub 2018 Sep 7.

Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America.

Background: Hepatitis D virus (HDV), which requires the presence of hepatitis B virus (HBV), is a deadly yet neglected disease that rapidly leads to liver cancer and disease-induced mortality. This co-dependence creates complex transmission dynamics that make it difficult to predict the efficacy of interventions aimed at HBV and/or HDV control in endemic regions, such as certain municipalities of Brazil, where up to 65% of HBV-infected persons are co-infected.

Methodology: We created a mathematical model that captures the joint transmission dynamics of HBV and HDV, incorporating mother-to-child, sexual and household transmission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203831PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128631PMC
September 2018

Current and Future Management of Chronic Hepatitis D.

Gastroenterol Hepatol (N Y) 2018 Jun;14(6):342-351

Dr Farci is chief of the Hepatic Pathogenesis Section of the Laboratory of Infectious Diseases at the National Institute of Allergy and Infectious Diseases in the National Institutes of Health in Bethesda, Maryland.

Hepatitis D virus (HDV) is a defective RNA virus that requires the hepatitis B surface antigen (HBsAg) of the hepatitis B virus (HBV) for its assembly, release, and transmission. HDV is highly pathogenic, causing the least common, but most severe, form of chronic viral hepatitis at all ages. Although significant advances have been made in the treatment of chronic viral hepatitis, targeting HDV remains a major challenge because of the unconventional nature of this virus and the severity of its disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111511PMC
June 2018
20 Reads

Small Hepatitis Delta Antigen Selectively Binds to Target mRNA in Hepatic Cells: A Potential Mechanism by Which Hepatitis D Virus Down-Regulates Glutathione S-Transferase P1 and Induces Liver Injury and Hepatocarcinogenesis.

Biochem Cell Biol 2018 Aug 28. Epub 2018 Aug 28.

Sichuan University, West China hospital, Chengdu, China ;

Liver co-infection by hepatitis B virus (HBV) and hepatitis D virus (HDV) can result in a severe form of hepatocellular carcinoma with poor prognosis. Co-infection with HDV and HBV causes more deleterious effects than infection with HBV alone. Clinical research has shown that glutathione S-transferase P1 (GSTP1), a tumor suppressor gene, is typically down-regulated in liver samples from hepatitis-infected patients. Read More

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http://dx.doi.org/10.1139/bcb-2017-0321DOI Listing
August 2018
5 Reads

High prevalence and diversity of hepatitis B and hepatitis delta virus in Gabon.

J Viral Hepat 2019 Jan 19;26(1):170-182. Epub 2018 Sep 19.

MIVEGEC, IRD/CNRS/Univ. Montpellier, Montpellier, France.

Although central Africa is classified as having a high endemicity of hepatitis B virus (HBV) and hepatitis D virus (HDV) infection, there is paucity of prevalence studies. For the first time on a country-wide level in Central Africa, we show in Gabon an overall 7.4% prevalence of Hepatitis B surface antigen (HBsAg) and that more than 25% of the HBsAg-positive population are infected by HDV. Read More

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http://dx.doi.org/10.1111/jvh.12991DOI Listing
January 2019
22 Reads

Determination of hepatitis B, C and D prevalence among urban and Amerindian populations from the Eastern Brazilian Amazon: a cross sectional study.

BMC Infect Dis 2018 Aug 20;18(1):411. Epub 2018 Aug 20.

Molecular Virology Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.

Background: This study was conducted to determine the prevalence of HBV, HCV, and HDV in urban populations and Amerindians living in the state of Tocantins (Eastern Amazon).

Methods: A total of 948 individuals were recruited in Tocantinopolis city (Tocantins state) of whom 603 were Amerindians (from 6 tribes) and 345 were non-Amerindians (6 urban areas of Tocantinópolis city). Anti-HCV, HBsAg, anti-HBc, anti-HBs, anti-HBc IgM, anti-HBe, HBeAg, and anti-delta antibodies were determined using enzyme immunoassay. Read More

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http://dx.doi.org/10.1186/s12879-018-3279-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102873PMC
August 2018
6 Reads

The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses.

Cell Mol Life Sci 2018 Nov 10;75(21):3895-3905. Epub 2018 Aug 10.

Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, 3 Rue Koeberlé, 67000, Strasbourg, France.

Chronic hepatitis B, C and D virus (HBV, HCV and HDV) infections are a major cause of liver disease and cancer worldwide. Despite employing distinct replication strategies, the three viruses are exclusively hepatotropic, and therefore depend on hepatocyte-specific host factors. The sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes that mediates the transport of bile acids, plays a key role in HBV and HDV entry into hepatocytes. Read More

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http://dx.doi.org/10.1007/s00018-018-2892-yDOI Listing
November 2018
5 Reads

Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets.

Emerg Microbes Infect 2018 Jul 26;7(1):134. Epub 2018 Jul 26.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, China.

Hepatitis B infections have become a serious public health issue globally, and the current first-line antiviral treatment for this disease is not a true cure. Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific bile acid transporter, was identified as a bona fide receptor for hepatitis B virus (HBV) and its satellite virus, hepatitis delta virus (HDV). Identification of the HBV receptor has led to the development of robust cell cultures and provides a potential target for new treatments. Read More

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http://dx.doi.org/10.1038/s41426-018-0137-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062556PMC
July 2018
13 Reads

The p.Ser267Phe variant of sodium taurocholate cotransporting polypeptide (NTCP) supports HBV infection with a low efficiency.

Virology 2018 09 19;522:168-176. Epub 2018 Jul 19.

National Institute of Biological Sciences, Beijing, 7 Science Park Road ZGC Life Science Park, Beijing 102206, China. Electronic address:

Sodium taurocholate cotransporting polypeptide (NTCP) is a functional receptor for human hepatitis B virus (HBV) and its satellite virus Hepatitis D virus (HDV). Physiologically, NTCP is responsible for the majority of sodium-dependent bile acids uptake by hepatocytes. The p. Read More

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http://dx.doi.org/10.1016/j.virol.2018.07.006DOI Listing
September 2018
8 Reads

Epidemiology and clinical outcomes of hepatitis delta (D) virus infection in Queensland, Australia.

Int J Infect Dis 2018 Sep 9;74:123-127. Epub 2018 Jul 9.

Department of Infectious Diseases, Royal Brisbane and Women's Hospital, Butterfield Street, Herston, Queensland 4029, Australia; School of Clinical Medicine, University of Queensland, Australia.

Objectives: To investigate the epidemiology, clinical characteristics and outcomes of those with hepatitis delta virus (HDV) infection in Queensland, Australia.

Design: Retrospective cohort study of individuals tested for HDV between 1997 and 2016 in the public healthcare system in Queensland.

Results: 179 individuals recorded positive HDV serology between 1997 and 2016, with a total of 4407 individuals undergoing testing (seroprevalence 4. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.07.005DOI Listing
September 2018
8 Reads

Epidemiology, Genotype Distribution, Prognosis, Control, and Management of Viral Hepatitis B, C, D, and Hepatocellular Carcinoma in Mongolia.

Euroasian J Hepatogastroenterol 2018 Jan-Jun;8(1):57-62. Epub 2018 May 1.

Department of Infectious Diseases, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; National Center for Communicable Diseases, Ulaanbaatar, Mongolia.

Mongolia is located between Russia and China. The total population of Mongolia as of December 2017 is estimated to be 3.2 million people. Read More

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http://www.jaypeejournals.com/eJournals/ShowText.aspx?ID=137
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http://dx.doi.org/10.5005/jp-journals-10018-1260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024043PMC
May 2018
22 Reads

A new dual-targeting real-time RT-PCR assay for hepatitis D virus RNA detection.

Diagn Microbiol Infect Dis 2018 Oct 29;92(2):112-117. Epub 2018 May 29.

Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Clinical Center for HIV/AIDS, Capital Medical University, Beijing, P.R. China. Electronic address:

In this study, a real-time reverse transcription-polymerase chain reaction (real time RT-PCR) assay targeting 2 genetic segments was established to detect HDV RNA. Utilizing the World Health Organization International Standard for Hepatitis D Virus RNA, the lower limit of detection was 575 IU/mL, and the linearity of quantification ranged from 575,000 IU/mL to 575 IU/mL. 384 HBsAg-positive samples collected from China were tested by this method and HDV antibody detection. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.05.016DOI Listing
October 2018
8 Reads

Low sero-prevalence of hepatitis delta antibodies in HIV/ hepatitis B co-infected patients attending an urban HIV clinic in Uganda.

Afr Health Sci 2017 Dec;17(4):974-978

Department of Medicine, Mulago Hospital and Makerere University College of Health Sciences, Kampala, Uganda.

Background: Co-infection with hepatitis B (HBV) and hepatitis D (HDV) is common among human immunodeficiency virus (HIV) infected individuals in developing countries and it aggressively accelerates progression of liver disease to cirrhosis and other complications. There is scarcity of data on HDV in sub-Saharan Africa .We investigated the sero-prevalence and factors associated with HDV antibody among HIV/HBV co-infected patients attending a large urban HIV clinic in Uganda. Read More

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http://dx.doi.org/10.4314/ahs.v17i4.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870270PMC
December 2017
8 Reads

Strategies for the treatment of HBV/HDV.

Eur J Pharmacol 2018 Aug 21;833:379-391. Epub 2018 Jun 21.

Department of Nuclear Medicine, Ruprecht-Karls University, University Hospital, 69120 Heidelberg, Germany. Electronic address:

An estimated 240 million people worldwide are chronically infected with the hepatitis B virus (HBV). Despite readily available vaccination, HBV infections remain highly prevalent. As established HBV infections constitute a strong risk factor for developing hepatocellular carcinoma their treatment is a major task for the health system. Read More

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http://dx.doi.org/10.1016/j.ejphar.2018.06.030DOI Listing
August 2018
2 Reads

Short article: Hepatitis delta in patients with resolved hepatitis B virus infection.

Eur J Gastroenterol Hepatol 2018 09;30(9):1063-1065

Infectious Diseases Unit, La Paz University Hospital.

Background: The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. Read More

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http://Insights.ovid.com/crossref?an=00042737-201809000-0001
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http://dx.doi.org/10.1097/MEG.0000000000001187DOI Listing
September 2018
3 Reads

Characterisation of the hepatitis B virus cross-species transmission pattern via Na+/taurocholate co-transporting polypeptides from 11 New World and Old World primate species.

PLoS One 2018 18;13(6):e0199200. Epub 2018 Jun 18.

Institute of Pharmacology and Toxicology, Biomedical Research Center Seltersberg, Justus Liebig University Giessen, Giessen, Germany.

The hepatic Na+/taurocholate co-transporting polypeptide (NTCP in man, Ntcp in animals) is the high-affinity receptor for the hepatitis B (HBV) and hepatitis D (HDV) viruses. Species barriers for human HBV/HDV within the order Primates were previously attributed to Ntcp sequence variations that disable virus-receptor interaction. However, only a limited number of primate Ntcps have been analysed so far. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199200PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005513PMC
December 2018
22 Reads

Hepatitis D virus infection in Kermanshah, west of Iran: seroprevalence and viremic infections.

Gastroenterol Hepatol Bed Bench 2018 ;11(2):145-152

Liver Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Aim: This study aimed to determine the seroprevalence and viremic infection of hepatitis delta virus (HDV) in Kermanshah.

Background: Hepatitis delta is one of the most complex viral infections of liver that along with hepatitis B virus could lead to fulminant hepatitis, progressive chronic hepatitis, cirrhosis, and hepatocellular carcinoma.

Methods: Referrals with positive HBs Ag were included and tested for HDV Ab using ELISA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990919PMC
January 2018
4 Reads

Viral dominance patterns in chronic hepatitis delta determine early response to interferon alpha therapy.

J Viral Hepat 2018 Nov 10;25(11):1384-1394. Epub 2018 Jul 10.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.

Chronic hepatitis D is caused by coinfection of hepatitis B and hepatitis D virus. While HDV is the dominant virus over HBV in the majority of cases, mechanisms and consequences of viral dominance are largely unknown. We aimed to investigate associations between viral dominance patterns and patients' characteristics and inflammatory features; 109 HDV-infected patients treated with PEG-IFNa-2α within the international multicentre, prospective HIDIT-2 trial were studied. Read More

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http://dx.doi.org/10.1111/jvh.12947DOI Listing
November 2018
25 Reads