87,848 results match your criteria Hepatitis C


AGA Clinical Practice Update on Interaction between Oral Direct-Acting Antivirals (DAAs) for Chronic Hepatitis C Infection and Hepatocellular Carcinoma: Expert Review.

Gastroenterology 2019 Mar 13. Epub 2019 Mar 13.

Section of Gastroenterology and Hepatology, Baylor College of Medicine, Houston TX; Houston Veterans Affairs Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX.

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http://dx.doi.org/10.1053/j.gastro.2019.02.046DOI Listing
March 2019
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Pathophysiology and Treatment of Hepatitis B and C Infections in Patients With End-Stage Renal Disease.

Adv Chronic Kidney Dis 2019 Jan;26(1):41-50

Division of Nephrology & Hypertension, Henry Ford Health System, Detroit, MI.

An in-depth understanding of viral hepatitis is important to the care of patients with end-stage renal disease undergoing hemodialysis. Both hepatitis B and C viruses are acquired through hematogenous spread and can lead to horizontal transmission. Concurrent hepatic and renal injuries have ominous outcomes with significant morbidity. Read More

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http://dx.doi.org/10.1053/j.ackd.2018.10.004DOI Listing
January 2019

Cellular Gene Expression during Hepatitis C Virus Replication as Revealed by Ribosome Profiling.

Int J Mol Sci 2019 Mar 15;20(6). Epub 2019 Mar 15.

Institute of Biochemistry, Medical Faculty, Justus-Liebig-University, Friedrichstrasse 24, 35392 Giessen, Germany.

Background: Hepatitis C virus (HCV) infects human liver hepatocytes, often leading to liver cirrhosis and hepatocellular carcinoma (HCC). It is believed that chronic infection alters host gene expression and favors HCC development. In particular, HCV replication in Endoplasmic Reticulum (ER) derived membranes induces chronic ER stress. Read More

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http://dx.doi.org/10.3390/ijms20061321DOI Listing

and Gene Variants in Liver Fibrosis and Cirrhosis.

Int J Mol Sci 2019 Mar 14;20(6). Epub 2019 Mar 14.

Department of Gastroenterology, Lithuanian University of Health Sciences, LT-50009 Kaunas, Lithuania.

Previous large-scale genetic studies identified single nucleotide polymorphisms (SNPs) of the and genes as risk factors for alcoholic liver cirrhosis and non-alcoholic fatty liver disease. In this study, we tried to evaluate the association between variant and variant and the risk of hepatic fibrosis or liver cirrhosis of different etiology. In parallel, we also aimed to evaluate whether these two SNPs modify the effects of the risk variant for the development of hepatic fibrosis and liver cirrhosis. Read More

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http://dx.doi.org/10.3390/ijms20061277DOI Listing

Taming a beast: lessons from the domestication of hepatitis C virus.

Curr Opin Virol 2019 Mar 12;35:27-34. Epub 2019 Mar 12.

The Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, United States. Electronic address:

"What I cannot create, I do not understand." Richard Feynman may have championed reasoning from first principles in his famous blackboard missive, but he could just as well have been referring to the plight of a molecular virologist. What cannot be grown in a controlled laboratory setting, we cannot fully understand. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18796257183013
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http://dx.doi.org/10.1016/j.coviro.2019.02.008DOI Listing
March 2019
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What Comes First: Treatment of Viral Hepatitis or Liver Cancer?

Dig Dis Sci 2019 Mar 14. Epub 2019 Mar 14.

Toronto Centre for Liver Disease, Toronto General Hospital, Sandra Rotman Centre for Global Health, University of Toronto, 200 Elizabeth Street, 9EB-240, Toronto, ON, M5G 2C4, Canada.

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the most important underlying causes for the development of hepatocellular carcinoma (HCC) worldwide. Determining the optimal approach for management of the viral infection and the HCC depends on the virus and the stage of the cancer. In patients with HCV-associated HCC, there are multiple reasons to first treat the HCC. Read More

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http://dx.doi.org/10.1007/s10620-019-05518-5DOI Listing

Screening for blood born viruses in assisted reproduction: is annual testing necessary?

Arch Gynecol Obstet 2019 Mar 14. Epub 2019 Mar 14.

IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, P.O. Box 5, Holon, 58100, Israel.

Purpose: Screening for blood born viruses is routinely performed before fertility treatment in assisted reproduction technology (ART) clinics worldwide. It involves testing for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV), among others. Identifying patients with positive viral screening allows to refer them and their partners for appropriate counseling and treatment. Read More

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http://link.springer.com/10.1007/s00404-019-05112-0
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http://dx.doi.org/10.1007/s00404-019-05112-0DOI Listing
March 2019
1 Read

Real-world effectiveness and safety of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C infection: data from the German Hepatitis C-Registry.

Aliment Pharmacol Ther 2019 Mar 15. Epub 2019 Mar 15.

Katholisches Klinikum Oberhausen, St. Josef-Hospital, Klinik für Innere Medizin, Akademisches Lehrkrankenhaus der Universität Duisburg-Essen, Oberhausen, Germany.

Background: Glecaprevir/pibrentasvir is a pangenotypic direct-acting antiviral regimen approved for treating adults chronically infected with hepatitis C virus (HCV). There are limited real-world data on glecaprevir/pibrentasvir to date.

Aim: To evaluate the effectiveness and safety of glecaprevir/pibrentasvir under real-world conditions in the German Hepatitis C-Registry (DHC-R). Read More

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http://dx.doi.org/10.1111/apt.15222DOI Listing

A Cross Sectional Study of the Impact of Human Immunodeficiency Virus, Hepatitis B Virus and Hepatitis C Virus on Rheumatoid Factor Production.

Arch Rheumatol 2018 Dec 31;33(4):402-407. Epub 2018 Jul 31.

University of Yaounde I, Faculty of Medicine and Biomedical Sciences, Yaounde, Cameroon.

Objectives: This study aims to investigate how human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) affect the production of immunoglobulin M (IgM)-rheumatoid factor (RF).

Patients And Methods: The study included 405 voluntary participants (139 males, 266 females; mean age 39.4±17. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2018.6076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409169PMC
December 2018

The efficacy and safety of glecaprevir plus pibrentasvir in 141 patients with severe renal impairment: a prospective, multicenter study.

Aliment Pharmacol Ther 2019 Mar 14. Epub 2019 Mar 14.

Tokyo, Japan.

Background: Patients with chronic hepatitis C are often complicated by chronic kidney disease (CKD).

Aim: To evaluate the efficacy, safety and pharmacokinetics of glecaprevir/pibrentasvir in patients with severe renal impairment.

Methods: In a prospective, multicentre study involving 35 medical institutions, 832 genotype 1-3 patients were treated with glecaprevir/pibrentasvir. Read More

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http://dx.doi.org/10.1111/apt.15218DOI Listing

Comparative effectiveness of pharmacist care delivery models for hepatitis C clinics.

Am J Health Syst Pharm 2019 Mar 15. Epub 2019 Mar 15.

Lifespan Corporation-Rhode Island Hospital, The Miriam Hospital, Bradley Hospital, Providence, RI, and Lifespan Pharmacy, LLC, Providence, RI.

Purpose: The optimal health care delivery models for providing services to patients with infections caused by hepatitis C virus (HCV) remain unknown. Pharmacist involvement may be a key component of optimal HCV care delivery. We examined the comparative effectiveness of a pharmacist-managed HCV clinic versus a pharmacist-assisted HCV clinic. Read More

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http://dx.doi.org/10.1093/ajhp/zxz034DOI Listing

Association of chronic inflammation and perceived stress with abnormal functional connectivity in brain areas involved with interoception in hepatitis C patients.

Brain Behav Immun 2019 Mar 11. Epub 2019 Mar 11.

Department of Psychiatry and Psychology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigacion Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain; Department of Medicine, Faculty of Medicine, and Institute of Neuroscience, University of Barcelona (UB), Barcelona, Spain. Electronic address:

Background: Sickness behavioral changes elicited by inflammation may become prolonged and dysfunctional in patients with chronic disease, such as chronic hepatitis C (CHC). Neuroimaging studies show that the basal ganglia and insula are sensitive to systemic inflammation.

Aim: To elucidate the clinical and neurobiological aspects of prolonged illnesses in patients with CHC. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.03.008DOI Listing

Epidemiology and management of hepatitis C virus infections in immigrant populations.

Infect Dis Poverty 2019 Mar 15;8(1):17. Epub 2019 Mar 15.

Department of Mental Health and Public Medicine, Section of Infectious Diseases, University of Campania, Via: L. Armanni 5, 80131, Naples, Italy.

Background: At present, there is a continuous flow of immigrants from the south of the world to north-western countries. Often immigrants originate from areas of high-prevalence of viral hepatitis and pose a challenge to the healthcare systems of the host nations. Aims of this study is to evaluate the prevalence and virological and clinical characteristics of hepatitis C virus (HCV) infection in immigrants and the strategies to identify and take care of the immigrants infected with HCV. Read More

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http://dx.doi.org/10.1186/s40249-019-0528-6DOI Listing

Sofosbuvir-based regimen is safe and effective for hepatitis C infected patients with stage 4-5 chronic kidney disease: a systematic review and meta-analysis.

Virol J 2019 Mar 14;16(1):34. Epub 2019 Mar 14.

Xiangya School of Public Health, Central South University, 110 Xiangya Road, Changsha, 410078, Hunan, China.

Background: Whether sofosbuvir is suitable for hepatitis C virus (HCV) infected patients with severe renal impairment is inconclusive. This systematic review aims to evaluate the safety and effectiveness of SOF-based regimen in the setting of stage 4 and 5 chronic kidney disease (CKD).

Methods: We conducted a systematic literature search in PubMed, Web of Science, EMBASE and Google Scholar with searching strategy: (sofosbuvir OR Sovaldi OR Harvoni OR Epclusa OR Vosevi) AND (severe kidney impairment OR severe renal impairment OR end-stage renal disease OR dialysis OR renal failure OR ESRD OR renal insufficiency OR hepatorenal syndrome OR HRS). Read More

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http://dx.doi.org/10.1186/s12985-019-1140-xDOI Listing

Potential of the Other Genetic Information Coded by the Viral RNA Genomes as Antiviral Target.

Pharmaceuticals (Basel) 2019 Mar 13;12(1). Epub 2019 Mar 13.

Instituto de Parasitología y Biomedicina López-Neyra, (IPBLN-CSIC); Av. del Conocimiento 17, PTS Granada, Armilla, 18016 Granada, Spain.

In addition to the protein coding information, viral RNA genomes code functional information in structurally conserved units termed functional RNA domains. These RNA domains play essential roles in the viral cycle (e.g. Read More

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http://dx.doi.org/10.3390/ph12010038DOI Listing
March 2019
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HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit.

Cells 2019 Mar 12;8(3). Epub 2019 Mar 12.

Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, a Joint Venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), 30625 Hannover, Germany.

The replication cycle of the liver-tropic hepatitis C virus (HCV) is tightly connected to the host lipid metabolism, during the virus entry, replication, assembly and egress stages, but also while the virus circulates in the bloodstream. This interplay coins viral particle properties, governs viral cell tropism, and facilitates immune evasion. This review summarizes our knowledge of these interactions focusing on the late steps of the virus replication cycle. Read More

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http://dx.doi.org/10.3390/cells8030233DOI Listing

Prevalence and risk factors of hepatitis B virus infection in Middle-Limburg Belgium, year 2017: importance of migration.

J Med Virol 2019 Mar 14. Epub 2019 Mar 14.

Department of Gastro-enterology and Hepatology, Ziekenhuis Oost-Limburg, Schiepse Bos 6, Genk, Belgium.

Background & Aims: The hepatitis B virus (HBV) prevalence study performed in 2003 in Belgium is believed to be underestimating HBV prevalence due to underrepresentation of the non-Belgian population. Therefore, we assessed the prevalence and risk factors of HBV infection in a multi-ethnic region situated in Middle-Limburg Belgium, in 2017.

Methods: Between May and November 2017, blood samples and questionnaires were taken from patients who presented at the emergency department of a large educational hospital. Read More

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http://dx.doi.org/10.1002/jmv.25457DOI Listing

Budgetary impact analysis of a primary care-based hepatitis C treatment program: Effects of 340B Drug Pricing Program.

PLoS One 2019 14;14(3):e0213745. Epub 2019 Mar 14.

Boston University, School of Medicine, Boston, MA, United States of America.

Purpose: Safety-net health systems, which serve a disproportionate share of patients at high risk for hepatitis C virus (HCV) infection, may use revenue generated by the federal drug discount pricing program, known as 340B, to support multidisciplinary care. Budgetary impacts of repealing the drug-pricing program are unknown. Our objective was to conduct a budgetary impact analysis of a multidisciplinary primary care-based HCV treatment program, with and without 340B support. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213745PLOS

Clinicopathological study of occult hepatitis B virus infection in hepatitis C virus-associated hepatocellular carcinoma.

Eur J Gastroenterol Hepatol 2019 Mar 11. Epub 2019 Mar 11.

Clinical Pathology, Mansoura Faculty of Medicine.

Background: Occult hepatitis B virus infection (OBI) frequently occurs in patients with chronic hepatitis C (CHC) infection, but the influence of OBI on CHC outcome is still uncertain. The aim of the present study was to clarify the clinical and pathological characteristics of OBI in CHC-related hepatocellular carcinoma (HCC).

Patients And Methods: DNA was obtained from serum and tumor tissue of patients with hepatitis C virus (HCV)-related HCC with negative HBsAg and from patients with HCV-related liver cirrhosis. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001388DOI Listing

[Hepatitis C facing the challenge of healing].

Authors:
Stanislas Pol

Rev Prat 2018 Mar;68(3):269-275

Université Paris-Descartes, Inserm U-1223, Centre de recherche translationnelle, Institut Pasteur ; département d'hépatologie, AP-HP, hôpital Cochin, Paris, France.

Hepatitis C facing the challenge of healing. Hepatitis C virus (HCV) infection affects 71 million people worldwide. It is a systemic disease associating hepatic manifestations, extra-hepatic manifestations by cryoglobulinemic vasculitis and general manifestations related to chronic inflammation (diabetes, cardio-, reno- or cerebrovascular manifestations and extrahepatic cancers including non-Hodgkin's lymphoma). Read More

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March 2018
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[Cryoglobulinemia for use].

Rev Prat 2018 Dec;68(10):1107-1112

Service d'immunohématologie, hôpital Saint-Louis, AP-HP, Paris, France.

Cryoglobulinemia. Cryoglobulinemia is defined by the presence of a circulating cryoglobulin, a cold-precipitating immunoglobulin. The typing of this cryoglobulin is fundamental. Read More

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December 2018
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Human Adenovirus type 5 increases host cell fucosylation and modifies Ley antigen expression.

Glycobiology 2019 Mar 14. Epub 2019 Mar 14.

Laboratorio de Glicobiología Humana y Diagnóstico Molecular; Centro de Investigación en Dinámica Celular, Instituto de Investigación en Ciencias Básicas y Aplicadas, Universidad Autónoma del Estado de Morelos. Av. Universidad 1001, Cuernavaca, México.

Certain viral infections are known to modify the glycosylation profile of infected cells through the overexpression of specific host cell fucosyltransferases (FUTs). Infection with CMV (cytomegalovirus), HCV (hepatitis C virus), HSV-1 (herpes simplex virus type-1) and VZV (varicella-zoster virus) increase the expression of fucosylated epitopes, including antigens sLex (Siaα2-3 Galβ1-4(Fucα1-3)GlcNAcβ1-R) and Ley (Fucα1-2 Galβ1-4(Fucα1-3)GlcNAcβ1-R). The reorganization of the glycocalyx induced by viral infection may favor the spread of viral progeny, and alter diverse biological functions mediated by glycans, including recognition by the adaptive immune system. Read More

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https://academic.oup.com/glycob/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/glycob/cwz017DOI Listing
March 2019
1 Read

Online symptom checker diagnostic and triage accuracy for HIV and hepatitis C.

Epidemiol Infect 2019 Jan;147:e104

Division of Infectious Diseases,University of South Alabama,Mobile, AL,USA.

We sought to address the prior limitations of symptom checker accuracy by analysing the diagnostic and triage feasibility of online symptom checkers using a consecutive series of real-life emergency department (ED) patient encounters, and addressing a complex patient population - those with hepatitis C or HIV. We aimed to study the diagnostic and triage accuracy of these symptom checkers in relation to an emergency room physician-determined diagnosis. An ED retrospective analysis was performed on 8363 consecutive adult patients. Read More

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http://dx.doi.org/10.1017/S0950268819000268DOI Listing
January 2019

Chronic hepatitis B and C infections in the Netherlands: estimated prevalence in risk groups and the general population.

Epidemiol Infect 2019 Jan;147:e147

Center for Infectious Disease Control,National Institute for Public Health and the Environment (RIVM),Bilthoven,The Netherlands.

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are usually asymptomatic for decades, thus targeted screening can prevent liver disease by timely diagnosis and linkage to care. More robust estimates of chronic HBV and HCV infections in the general population and risk groups are needed. Using a modified workbook method, the total number of ever chronically infected individuals in the Netherlands in 2016 was determined using population size and prevalence estimates from studies in the general and high-risk population. Read More

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http://dx.doi.org/10.1017/S0950268819000359DOI Listing
January 2019
1 Read

Seroprevalence of HCV, HBV and HIV in two inner-city London emergency departments.

Epidemiol Infect 2019 Jan;147:e145

Immunisation, Hepatitis and Blood Safety Department,Centre for Infectious Disease Surveillance & Control (CIDSC), National Infection Service, Public Health England,London,UK.

Summary: In this paper we build on work investigating the feasibility of human immunodeficiency virus (HIV) testing in emergency departments (EDs), estimating the prevalence of hepatitis B, C and HIV infections among persons attending two inner-London EDs, identifying factors associated with testing positive in an ED. We also undertook molecular characterisation to look at the diversity of the viruses circulating in these individuals, and the presence of clinically significant mutations which impact on treatment and control.Blood-borne virus (BBV) testing in non-traditional settings is feasible, with emergency departments (ED) potentially effective at reaching vulnerable and underserved populations. Read More

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http://dx.doi.org/10.1017/S0950268819000360DOI Listing
January 2019

Understanding of HIV/AIDS in the international border area, Manipur: Northeast India.

Epidemiol Infect 2019 Jan;147:e113

Cancer and Molecular Biology Division,Department of Biotechnology,Manipur University,Canchipur-795003, Manipur,India.

Manipur, an international border region has the highest incidence of human immunodeficiency virus (HIV)-1 infection in India. Nevertheless, there have been no analytical reviews of research article published within this region. In this review, the authors aim to draw the attention of policy makers, medical practitioners and researchers in adopting new strategies to limit the expansion of HIV/acquired immunodeficiency syndrome (AIDS) not only in Manipur but also in other international border areas. Read More

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http://dx.doi.org/10.1017/S0950268818003564DOI Listing
January 2019

Integrated analysis of 8-week glecaprevir/pibrentasvir in Japanese and overseas patients without cirrhosis and with hepatitis C virus genotype 1 or 2 infection.

J Gastroenterol 2019 Mar 13. Epub 2019 Mar 13.

Toranomon Hospital, Tokyo, Japan.

Background: Chronic hepatitis C virus (HCV) infection with genotypes (GT) 1 and 2 accounts for over 50% of HCV infections globally, including over 97% of all HCV infections in Japan. Here, we report an integrated analysis of efficacy and safety of 8-week treatment with the all-oral, fixed-dose combination of the direct acting antivirals (DAA), glecaprevir and pibrentasvir (G/P), in DAA-naïve Japanese and overseas patients without cirrhosis and with HCV GT1 or GT2 infection.

Methods: Data from 899 DAA-naïve patients without cirrhosis and with HCV GT1 or GT2 infection treated with G/P (300/120 mg) for 8 weeks in the six Phase 2 or 3 overseas or Japan-only clinical trials were included. Read More

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http://dx.doi.org/10.1007/s00535-019-01569-7DOI Listing

Transfusion Transmissible Infections: Maximizing Donor Surveillance.

Cureus 2018 Dec 28;10(12):e3787. Epub 2018 Dec 28.

Immunology, Shifa International Hospital, Islamabad, PAK.

Introduction The World Health Organization (WHO) recommends that all blood transfusion services must screen donated blood for human immunodeficiency virus (HIV) one and two, hepatitis B, hepatitis C and syphilis. A mandatory screening for malaria is also warranted in malaria endemic areas. Our study aimed at analyzing the prevalence and different diagnostic methods of screening transfusion transmitted infections (TTIs) in replacement and voluntary, non-remunerated donors in the blood bank of a tertiary care hospital in Islamabad, Pakistan. Read More

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http://dx.doi.org/10.7759/cureus.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402742PMC
December 2018

Response to: Comment on "Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients".

Dis Markers 2019 5;2019:2520302. Epub 2019 Feb 5.

Laboratorio de Virología Molecular, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.

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http://dx.doi.org/10.1155/2019/2520302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379871PMC
February 2019

Hepatic resection for hepatocellular carcinoma in the octogenarian: is it justified?

Aging (Albany NY) 2019 Mar;11(5):1537-1550

Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Guishan, Taoyuan, Taiwan.

Liver resection is a standard treatment for hepatocellular carcinoma (HCC). The purpose of this study was to investigate the clinicopathological characteristics and long-term outcomes of octogenarians with HCC treated with liver resection. Records of patients who underwent liver resection for HCC were reviewed, and patients older and younger than 80 years were compared. Read More

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http://www.aging-us.com/article/101854/text
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http://dx.doi.org/10.18632/aging.101854DOI Listing
March 2019
1 Read

The hepatitis C virus RNA-dependent RNA polymerase directs incoming nucleotides to its active site through magnesium-dependent dynamics within its F motif.

J Biol Chem 2019 Mar 13. Epub 2019 Mar 13.

Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, France.

RNA viruses synthesize new genomes in the infected host thanks to dedicated, virally-encoded RNA-dependent RNA polymerases (RdRps). As such, these enzymes are prime targets for antiviral therapy, as has recently been demonstrated for hepatitis C virus (HCV). However, peculiarities in the architecture and dynamics of RdRps raise fundamental questions about access to their active site during RNA polymerization. Read More

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http://dx.doi.org/10.1074/jbc.RA118.005209DOI Listing

Should we screen people at increased risk of hepatitis C virus infection?

Authors:

Can Fam Physician 2019 Mar;65(3):195-196

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The health equity implementation framework: proposal and preliminary study of hepatitis C virus treatment.

Implement Sci 2019 Mar 12;14(1):26. Epub 2019 Mar 12.

Center for Mental Healthcare & Outcomes Research, Central Arkansas Veterans Healthcare System, U.S. Department of Veterans Affairs, 2200 Fort Roots Drive, 152 NLR, North Little Rock, AR, 72114, USA.

Background: Researchers could benefit from methodological advancements to advance uptake of new treatments while also reducing healthcare disparities. A comprehensive determinants framework for healthcare disparity implementation challenges is essential to accurately understand an implementation problem and select implementation strategies.

Methods: We integrated and modified two conceptual frameworks-one from implementation science and one from healthcare disparities research to develop the Health Equity Implementation Framework. Read More

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https://implementationscience.biomedcentral.com/articles/10.
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http://dx.doi.org/10.1186/s13012-019-0861-yDOI Listing
March 2019
1 Read

Family Practitioner-Directed Hepatitis C Therapy With Direct-Acting Antivirals Achieves High-Sustained Virologic Response in Prison Population.

J Correct Health Care 2019 Mar 13:1078345819832875. Epub 2019 Mar 13.

3 Mule Creek State Prison, California Department of Corrections and Rehabilitation, Ione, CA, USA.

The burden of hepatitis C virus (HCV) infection is disproportionately high in U.S. federal and state prisons. Read More

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http://dx.doi.org/10.1177/1078345819832875DOI Listing

Prevalence and risk factors associated with hepatitis C among Brazilian male patients with haemophilia: A long-term follow-up.

Haemophilia 2019 Mar 13. Epub 2019 Mar 13.

Faculdade de Medicina da, Universidade José do Rosário Vellano, Belo Horizonte, Brazil.

People with haemophilia represent a population with a high prevalence of HCV infection due to the use of blood components and plasma-derived clotting factor concentrates before the introduction of viral-inactivating procedures (in the 1980s) and screening for HCV (in the 1990s). About 80% of HCV-infected patients have chronic HCV infection, and at least 20% develop end-stage liver disease. The aim of the study was to assess current anti-HCV positivity in a large cohort of Brazilian haemophilia patients and to determine associated factors with HCV exposure. Read More

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http://dx.doi.org/10.1111/hae.13728DOI Listing
March 2019
1 Read

Decreasing Frequency and Improved Outcomes of Hepatitis C Related Liver Transplantation in the Era of Direct Acting Antivirals.

Transpl Int 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine, Division of Gastroenterology and Hepatology, University of South Dakota, Sioux Falls, SD.

Background: Benefit of direct acting antivirals (DAA) for HCV on clinical outcomes is unclear.

Methods: We examined temporal trends in liver transplant (LT) listings, receipt of LT, re-LT and survival between pre-DAA (2009-2012) and DAA era (2013-2016) using UNOS database.

Results: Of 32,319 first adult LT, 15049 (47%) were performed for HCV. Read More

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http://dx.doi.org/10.1111/tri.13424DOI Listing
March 2019
2.599 Impact Factor

Clinical outcomes in HIV+/HCV+ coinfected kidney transplant recipients in the pre- and post-direct acting antiviral (DAA) therapy eras: 10-year single center experience.

Clin Transplant 2019 Mar 13:e13532. Epub 2019 Mar 13.

Department of Medicine, Division of Nephrology, University of Miami Miller School of Medicine Miami, FL.

Background: Previous studies have demonstrated inferior patient and graft survival following kidney transplant (KT) in HIV+/HCV+ coinfected patients compared to HIV+/HCV- recipients. However, these studies were conducted prior to the availability of direct acting antiviral (DAA) agents and data in the modern era is lacking.

Methods: Single center retrospective study of HIV+/HCV+ coinfected KT recipients (2007-2017). Read More

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http://doi.wiley.com/10.1111/ctr.13532
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http://dx.doi.org/10.1111/ctr.13532DOI Listing
March 2019
1 Read

Differential prevalence and geographic distribution of hepatitis C virus genotypes in acute and chronic hepatitis C patients in Vietnam.

PLoS One 2019 13;14(3):e0212734. Epub 2019 Mar 13.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Background: The highest burden of disease from hepatitis C virus (HCV) is found in Southeast Asia, but our understanding of the epidemiology of infection in many heavily burdened countries is still limited. In particular, there is relatively little data on acute HCV infection, the outcome of which can be influenced by both viral and host genetics which differ within the region. We studied HCV genotype and IL28B gene polymorphism in a cohort of acute HCV-infected patients in Southern Vietnam alongside two other cohorts of chronic HCV-infected patients to better understand the epidemiology of HCV infection locally and inform the development of programs for therapy with the increasing availability of directly acting antiviral therapy (DAAs). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212734PLOS
March 2019
2 Reads

Fibrosis reversal after hepatitis C virus elimination.

Authors:
Don C Rockey

Curr Opin Gastroenterol 2019 Mar 6. Epub 2019 Mar 6.

Department of Internal Medicine, The Medical University of South Carolina, Charleston, USA.

Purpose Of Review: Hepatitis C virus (HCV) infection has been the leading cause of cirrhosis in the United States now for the last several decades. With the introduction of highly effective direct acting antiviral (DAA) drugs, cure rates are now almost 100%. With this explosion of effective therapy, it is possible that many patients with HCV may have reversion in fibrosis. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000524DOI Listing

Prevalence of Anti-HCV Antibody Among the General Population in Mainland China Between 1991 and 2015: A Systematic Review and Meta-analysis.

Open Forum Infect Dis 2019 Mar 6;6(3):ofz040. Epub 2019 Feb 6.

Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Beijing, China.

Our study aims to estimate the burden of hepatitis C virus (HCV) infection among the general population in Mainland China. We searched 4 databases for studies of the prevalence of anti-HCV antibody among the general population. Studies that met the selection criteria were included in the meta-analysis. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz04
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http://dx.doi.org/10.1093/ofid/ofz040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408870PMC
March 2019
2 Reads

Multi-drug-resistant bacteraemia in a liver transplant recipient.

JMM Case Rep 2019 Jan 20;6(1):e005172. Epub 2018 Dec 20.

Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA, USA.

Introduction: is a commensal organism commonly colonizing the human gastrointestinal tract. Although it is generally a non-virulent organism, can cause significant morbidity and mortality due to its inherent and acquired resistances to commonly used antimicrobials. Patients who are immunosuppressed are particularly vulnerable. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412035PMC
January 2019

Phosphorylated tyrosine 93 of hepatitis C virus nonstructural protein 5A is essential for interaction with host c-Src and efficient viral replication.

J Biol Chem 2019 Mar 12. Epub 2019 Mar 12.

Structural Biochemistry (ICS-6), Forschungszentrum Jülich, Germany.

The hepatitis C virus (HCV) nonstructural protein 5A (NS5A) plays a key role in viral replication and virion assembly, and regulation of the assembly process critically depends on phosphorylation of both serine and threonine residues in NS5A. We previously identified SRC proto-oncogene, non-receptor tyrosine kinase (c-Src) as an essential host component of the HCV replication complex consisting of NS5A, the RNA-dependent RNA polymerase NS5B, and c-Src. Pull-down assays revealed an interaction between NS5A and the Src-homology 2 (SH2) domain of c-Src; however, the precise binding mode remains undefined. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007656DOI Listing

APOBEC3G is a restriction factor of EV71 and mediator of IMB-Z antiviral activity.

Antiviral Res 2019 Mar 9;165:23-33. Epub 2019 Mar 9.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing, 100050, China. Electronic address:

Enterovirus 71 (EV71), a single-stranded positive-sense RNA virus, is the causative agent of hand, foot, and mouth disease (HFMD), for which no effective antiviral therapy is currently available. Apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or A3G) is a cytidine deaminase that inhibits the replication of several viruses, such as human immunodeficiency virus-1, hepatitis B virus and hepatitis C virus. In our efforts toward understanding the antiviral spectrum and mechanism of A3G, we found that ectopic expression of A3G inhibited EV71 replication, whereas knockdown of endogenous A3G expression promoted EV71 replication. Read More

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http://dx.doi.org/10.1016/j.antiviral.2019.03.005DOI Listing
March 2019
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Increasing importance of European lineages in seeding the hepatitis C virus subtype 1a epidemic in Spain.

Euro Surveill 2019 Feb;24(9)

KU Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Clinical and Epidemiological Virology, Leuven, Belgium.

BackgroundReducing the burden of the hepatitis C virus (HCV) requires large-scale deployment of intervention programmes, which can be informed by the dynamic pattern of HCV spread. In Spain, ongoing transmission of HCV is mostly fuelled by people who inject drugs (PWID) infected with subtype 1a (HCV1a).AimOur aim was to map how infections spread within and between populations, which could help formulate more effective intervention programmes to halt the HCV1a epidemic in Spain. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.9.1800227DOI Listing
February 2019

Synthesis of New Indanyl Nucleoside Analogues and their Biological Evaluation on Hepatitis C Virus (HCV) Replicon.

Molecules 2019 Mar 11;24(5). Epub 2019 Mar 11.

Cátedra de Química Medicinal, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina.

Here, we report a convenient synthetic procedure for the preparation of four novel indanyl carbanucleoside derivatives in the racemic form. The action of these compounds against hepatitis C virus was evaluated in vitro using the replicon cell line, Huh7.5 SG. Read More

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http://dx.doi.org/10.3390/molecules24050990DOI Listing

The potential regulatory role of miR16 to the interplay between interferon and transforming growth factor beta pathways through IRF3 and SMAD7 in hepatitis C virus infected patients.

J Cell Biochem 2019 Mar 12. Epub 2019 Mar 12.

Department of Internal Medicine, Gastroentrology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: The defensive strategy against hepatitis C virus (HCV) infection depends on two antiviral pathways; interferon (IFN) and transforming growth factor β (TGFβ). We aimed at verifying the relation between TGFβ and IFN antiviral pathways in HCV infection through SMAD7 and IRF3, and whether a possible regulatory role for microRNA-16 (miR16) on the interplay between IFN and TGFβ signaling pathways exists or not.

Methods: We evaluated miR16, IRF3 and SMAD7 expression by real-time polymerase chain reaction in HCV infected patients and age and gender matched healthy controls. Read More

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http://doi.wiley.com/10.1002/jcb.28537
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http://dx.doi.org/10.1002/jcb.28537DOI Listing
March 2019
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Drug-Drug Interactions of Tacrolimus or Cyclosporine With Glecaprevir and Pibrentasvir in Healthy Subjects.

Clin Pharmacol Drug Dev 2019 Mar 12. Epub 2019 Mar 12.

Clinical Pharmacology and Pharmacometrics, AbbVie Inc., North Chicago, IL, USA.

A fixed-dose combination of glecaprevir and pibrentasvir is approved for treatment of chronic infection with hepatitis C virus (HCV) genotypes 1-6. Three phase 1 open-label studies were conducted in healthy volunteers to evaluate the potential for clinically relevant drug-drug interactions of the glecaprevir 300-mg and pibrentasvir 120-mg combination with the immunosuppressants tacrolimus (1 mg) or cyclosporine (100 and 400 mg). Glecaprevir and pibrentasvir exposure was unaffected by tacrolimus, whereas the tacrolimus area under the curve (AUC) value was 45% higher with glecaprevir and pibrentasvir. Read More

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http://dx.doi.org/10.1002/cpdd.671DOI Listing
March 2019
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Hepatitis B and C virus infections transmitted through organ transplantation investigated by CDC, United States, 2014-2017.

Am J Transplant 2019 Mar 12. Epub 2019 Mar 12.

Division of Viral Hepatitis, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia.

We evaluated clinical outcomes among organ recipients with donor-derived hepatitis B virus (HBV) or hepatitis C virus (HCV) infections investigated by CDC from 2014-2017 in the United States. We characterized new HBV infections in organ recipients if donors tested negative for total anti-HBc, HBsAg and HBV DNA, and new recipient HCV infections if donors tested negative for anti-HCV and HCV RNA. Donor risk behaviors were abstracted from next-of-kin interviews and medical records. Read More

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http://dx.doi.org/10.1111/ajt.15352DOI Listing

Comparison of Efficacy of Sofosbuvir plus Ribavirin in Chinese Patients with Genotype 3a or 3b HCV Infection.

J Med Virol 2019 Mar 12. Epub 2019 Mar 12.

Peking University People's Hospital, Peking University Hepatology Institute, Beijing Key Laboratory for Hepatitis C and Immunotherapy for Liver Disease, Beijing, China.

Background & Aims: Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir plus ribavirin in Chinese patients with genotype 3a and 3b HCV.

Methods: The analyzed data are from a phase 3, open-label study of sofosbuvir plus ribavirin for 24 weeks conducted in China. Read More

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http://doi.wiley.com/10.1002/jmv.25454
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http://dx.doi.org/10.1002/jmv.25454DOI Listing
March 2019
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2.347 Impact Factor

Lighting up the Native Viral RNA Genome with a Fluorogenic Probe for the Live-Cell Visualization of Virus Infection.

J Am Chem Soc 2019 Mar 12. Epub 2019 Mar 12.

RNA viruses represent a major global health threat, and the visualization of their RNA genome in infected cells is essential for virological research and clinical diagnosis. Due to the lack of chemical toolkits for the live-cell imaging of viral RNA ge-nomes, especially native viral genomes without labeling and genetic modification, studies on native virus infection at the single live-cell level are challenging. Herein, taking hepatitis C virus (HCV) as a representative RNA virus, we propose that the innate noncanonical G-quadruplex (G4) structure of viral RNA can serve as a specific imaging target and report a new benzothiazole-based G4-targeted fluorescence light-up probe, ThT-NE, for the direct visualization of the native RNA ge-nome of HCV in living host cells. Read More

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http://dx.doi.org/10.1021/jacs.8b10265DOI Listing