27,293 results match your criteria Hepatitis A


The use of normal human immunoglobulin (NHIG) for public health purposes in Queensland 2004-2014 and Australia 2014-2016

Commun Dis Intell (2018) 2019 Mar 15;43. Epub 2019 Mar 15.

School of Medicine and Menzies Health Institute Queensland, Griffith University - Metro North Public Health Unit, Metro North Hospital and Health Service

Objective To describe the use of normal human immunoglobulin (NHIG) recommended for public health purposes in Queensland and Australia. Methods Queensland public health unit (PHU) data on notified cases of measles, rubella and hepatitis A from 2004 to 2014 were examined; particularly regarding the number of contacts offered NHIG and the volume recommended per contact. The National Blood Authority (NBA) provided unidentified data from NHIG order form inception (June 2014) through December 2016. Read More

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Hepatovirus 3ABC proteases and evolution of mitochondrial antiviral signaling protein (MAVS).

J Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Microbiology & Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:

Background & Aims: Unlike other hepatitis viruses that have infected primates for millions of years, hepatitis A virus (HAV) likely entered human populations only 10-12 thousand years ago after jumping from a rodent host. The phylogeny of modern hepatoviruses infecting rodents and bats suggest multiple similar host shifts have occurred in the past. The factors determining such shifts are unknown, but the capacity to overcome innate antiviral responses in a foreign species is likely key. Read More

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http://dx.doi.org/10.1016/j.jhep.2019.02.020DOI Listing

Hepatitis A outbreak associated with a food handler in Bizkaia, 2017.

Enferm Infecc Microbiol Clin 2019 Mar 12. Epub 2019 Mar 12.

Unidad de Hepatitis, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, España.

Introduction: The reporting of one case of hepatitis A in a food handler at a bakery and five cases in employees of a company after consuming products from the same bakery prompted an outbreak investigation.

Methods: Outbreak cases were defined as individuals with laboratory-confirmed hepatitis A (HAV) infection, with symptoms which started in June and who, during the incubation period, worked with the food handler and/or had close contact with him and/or consumed products from the bakery. Epidemiologic questionnaires were performed and blood samples were obtained to be tested for the presence of anti-hepatitis A antibodies. Read More

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http://dx.doi.org/10.1016/j.eimc.2019.01.011DOI Listing

Hepatitis A infection related haemophagocytic syndrome: a case report and systematic review.

Trop Doct 2019 Mar 14:49475519834804. Epub 2019 Mar 14.

2 Professor, Department of Gastroenterology, PGIMER, Chandigarh, India.

Haemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome of excessive inflammation and tissue destruction owing to abnormal immune activation. We report an unusual case of haemophagocytosis associated with hepatitis A virus (HAV) infection in a 21-year-old man. This was further complicated by haemolysis secondary to G-6-PD deficiency and fungal sepsis. Read More

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http://dx.doi.org/10.1177/0049475519834804DOI Listing
March 2019
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[The challenges of hepatitis A vaccine].

Rev Prat 2018 Mar;68(3):291-292

Service de virologie, Centre national de référence des virus des hépatites à transmission entérique, Inserm U1193, hôpital Paul-Brousse, Villejuif, France.

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Oral fluid testing facilitates understanding of hepatitis A virus household transmission.

Epidemiol Infect 2019 Jan;147:e105

Blood Borne Virus Unit, National Infection Service,Public Health England,London,UK.

The public health response to sporadic hepatitis A virus (HAV) infection, hepatitis A, can be complex especially when the index case is a child and no obvious source is identified. Identifying an infection source may avoid mass immunisation within schools when transmission is found to have occurred within the household. Screening of asymptomatic contacts via venepuncture can be challenging and unacceptable, as a result non-invasive methods may facilitate public health intervention. Read More

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http://dx.doi.org/10.1017/S095026881900027XDOI Listing
January 2019

Outbreak of hepatitis A genotype IB in Australia associated with imported frozen pomegranate arils.

Epidemiol Infect 2019 Jan;147:e74

NSW Ministry of Health,Sydney,Australia.

Locally acquired hepatitis A infection is re-emerging in Australia owing to person-to-person outbreaks among men who have sex with men and imported frozen produce. This paper describes a multi-state foodborne outbreak in the first half of 2018. Enhanced human epidemiological investigation including a case-control study, as well as microbial surveillance and trace-back investigations concluded that the outbreak was caused by consumption of imported frozen pomegranate arils. Read More

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http://dx.doi.org/10.1017/S0950268818003515DOI Listing
January 2019

Hepatitis A Outbreak in the General Population due to a MSM-Associated HAV Genotype Linked to a Food Handler, November 2017-February 2018, Germany.

Food Environ Virol 2019 Mar 13. Epub 2019 Mar 13.

Health Authority Amberg-Sulzbach, Amberg, Germany.

Hepatitis A (HAV) is a viral infection causing a range of symptoms, sudden onset of fever, malaise, diarrhea, and jaundice. It is mostly transmitted fecal-oral through contaminated food, with immediate household and sexual contacts having a higher risk of infection. Since 2016 an increased number of HAV infections, mostly affecting men who have sex with men (MSM) have been noticed worldwide, with three main genotypes circulating. Read More

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http://dx.doi.org/10.1007/s12560-019-09375-3DOI Listing

Adult Vaccination Rates in the Mentally Ill Population: An Outpatient Improvement Project.

J Am Psychiatr Nurses Assoc 2019 Mar 13:1078390319831763. Epub 2019 Mar 13.

4 Lacey Eden, MS, FNP, Brigham Young University, Provo, UT, USA.

Background: Adults who suffer with severe and persistent mental illness (SPMI) rarely access medical care to receive preventive vaccines.

Aims: To increase the rate of vaccines among the SPMI population in an outpatient community mental health center (CMHC).

Methods: A review of the literature identified a gap between the general population and SPMI clients in receiving preventive vaccinations. Read More

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http://journals.sagepub.com/doi/10.1177/1078390319831763
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http://dx.doi.org/10.1177/1078390319831763DOI Listing
March 2019
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Viral safety of APOSEC: a novel peripheral blood mononuclear cell derived-biological for regenerative medicine.

Blood Transfus 2019 Feb 21. Epub 2019 Feb 21.

Division of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.

Background: Viral reduction and inactivation of cell-derived biologicals is paramount for patients' safety and so viral reduction needs to be demonstrated to regulatory bodies in order to obtain marketing authorisation. Allogeneic human blood-derived biological medicinal products require special attention. APOSEC, the secretome harvested from selected human blood cells, is a new biological with promising regenerative capabilities. Read More

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http://dx.doi.org/10.2450/2019.0249-18DOI Listing
February 2019

Probiotics to prevent infantile colic.

Cochrane Database Syst Rev 2019 Mar 13;3:CD012473. Epub 2019 Mar 13.

Child Health Department, Blackpool Victoria Hospital, Whinney Heys Road, Blackpool, Lancashire, UK, FY3 8NR.

Background: Infantile colic is typically defined as full-force crying for at least three hours per day, on at least three days per week, for at least three weeks. Infantile colic affects a large number of infants and their families worldwide. Its symptoms are broad and general, and while not indicative of disease, may represent a serious underlying condition in a small percentage of infants who may need a medical assessment. Read More

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http://doi.wiley.com/10.1002/14651858.CD012473.pub2
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http://dx.doi.org/10.1002/14651858.CD012473.pub2DOI Listing
March 2019
1 Read

Response to hepatitis A virus vaccine in HIV-infected patients within a retrospective, multicentric cohort: Facing hepatitis A outbreaks in the clinical practice.

J Acquir Immune Defic Syndr 2019 Feb 14. Epub 2019 Feb 14.

Unidad de Enfermedades Infecciosas, Microbiología y Medicina Preventiva. Hospital Universitario Virgen del Rocío, Sevilla, Spain.

Background: Various recent outbreaks of hepatitis A virus (HAV) have been described in men who have sex with men (MSM) despite the availability of an effective vaccine. This study aimed to determine the current rates of seroconversion after receiving HAV vaccine (HAV-V) in HIV-infected patients under real-life conditions.

Setting: Patients were selected from a Southern Spanish multicentric cohort of HIV-infected subjects. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001990DOI Listing
February 2019

Hepatitis A and E Outbreak Surveillance during 2015-2017 in Kashmir, India: Is the Water to Blame?

J Epidemiol Glob Health 2018 Dec;8(3-4):203-207

Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Waterborne diseases, such as hepatitis A and E, are a major public health concern in most developing countries, indicating the need for proper outbreak prevention, surveillance, and timely management. This study presents data regarding the prevalence and epidemiological characteristics of hepatitis A and E outbreaks as well as water quality in Kashmir, India, during 2015-2017. Hepatitis outbreaks were initially investigated by rapid response teams, under the Integrated Disease Surveillance Programme. Read More

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http://dx.doi.org/10.2991/j.jegh.2018.04.101DOI Listing
December 2018
2 Reads

Changes in seroprevalence of hepatitis A after the implementation of universal children vaccination in Shandong Province, China: a comparison between 2006 and 2014.

Int J Infect Dis 2019 Mar 9. Epub 2019 Mar 9.

Academy of Preventive Medicine, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, China. Electronic address:

Objectives: Hepatitis A vaccine (HepA) has been involved in national Expanded Program on Immunization (EPI) in China since 2008. The present study evaluated the dynamics change in seroepidemiology of hepatitis A virus (HAV) before and after the introduction of the program.

Methods: The trends in the seroepidemiology of anti-HAV antibodies were examined in Shandong Province, China, drawing on the two population-based samples from persons aged 1-59 years conducted in 2006 (n=6682) and 2014 (n=5095), respectively. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.03.005DOI Listing

Characteristics of Acute Hepatitis A Virus Infection Before and After 2001: A Hospital-based Study in Tokyo, Japan.

J Gastroenterol Hepatol 2019 Mar 12. Epub 2019 Mar 12.

Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: The incidence of acute hepatitis A [AH (A)] is decreasing due to improvements in hygiene; however, cases of sporadic severe hepatitis are still being reported. We assessed the epidemiology of AH (A) in Japan.

Methods: This was a hospital-based retrospective study, in which 126 AH (A) patients [96 males (76%), median age 39 (range, 19-66) years] were enrolled. Read More

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http://dx.doi.org/10.1111/jgh.14655DOI Listing

A case report of leukocytoclastic vasculitis after vaccination in a patient with inflammatory bowel disease.

Rev Esp Enferm Dig 2019 Mar 12;111. Epub 2019 Mar 12.

Unidad Enf. Inflam. Intest. Servicio de Digestivo., Hospital Universitario Central de Asturias.

Patients with inflammatory bowel disease are likely to receive immunomodulation treatment and therefore, should be properly vaccinated. Despite their proven safety, vaccines are not exempt from adverse reactions. The clinical case was a young female with ulcerative colitis under mesalazine treatment, who developed leukocytoclastic vasculitis following vaccination for pneumococci, varicella and hepatitis A. Read More

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http://dx.doi.org/10.17235/reed.2019.5963/2018DOI Listing

Incidence, prevalence, and causes of death of patients with autoimmune hepatitis: A nationwide register-based cohort study in Finland.

Dig Liver Dis 2019 Feb 10. Epub 2019 Feb 10.

Department of Gastroenterology, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

Background: Epidemiological studies of autoimmune hepatitis are scarce and often based on single centre registries.

Aims: We conducted a nationwide register study of incidence, prevalence, survival, and causes of death of autoimmune hepatitis patients in Finland.

Methods: Autoimmune hepatitis cases 1995-2015 were retrieved from the national database of special reimbursements for drugs costs. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.015DOI Listing
February 2019
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Vaccination differences among U.S. adults by their self-identified sexual orientation, National Health Interview Survey, 2013-2015.

PLoS One 2019 7;14(3):e0213431. Epub 2019 Mar 7.

Morehouse School of Medicine, Atlanta, Georgia, United States of America.

Introduction: Very few studies have explored the associations between self-identified sexual orientation and comprehensive vaccination coverage. Most of the previous studies that reported health disparities among lesbian, gay and bisexual populations were not based on a nationally representative sample of U.S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213431PLOS
March 2019
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New 4-phenylcoumarin derivatives as potent 3C protease inhibitors: Design, synthesis, anti-HAV effect and molecular modeling.

Eur J Med Chem 2019 Apr 16;168:447-460. Epub 2019 Feb 16.

Environmental Virology Laboratory, Water pollution Research Department, Environmental Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza, p.o. box 12622, Egypt.

A new series of 4-phenylcoumarin derivatives was synthesized starting from (2-oxo-4-phenyl-2H-chromen-7-yloxy) acetic acid hydrazide 3. Evaluation of the target compounds for their antiviral activity against hepatitis A virus revealed that the ethylthiosemicarbazide derivative 7b was the most potent virucidal agent (IC = 3.1 μg/ml, TI = 83). Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.048DOI Listing
April 2019
3.447 Impact Factor

Fatal fulminant hepatitis A in a US traveller returning from Peru.

J Travel Med 2019 Mar 7. Epub 2019 Mar 7.

Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora CO, USA.

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http://dx.doi.org/10.1093/jtm/taz008DOI Listing
March 2019
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The effect of the infection within the individual host on its propagation in the population.

Infect Dis Model 2018 20;3:345-361. Epub 2018 Nov 20.

Faculdade de Medicina, Universidade de São Paulo e LIM01-HCFMUSP, Av. Dr. Arnaldo 455, São Paulo, SP, 01246-903, Brazil.

We consider nested or multiscale models to study the effect of the temporal evolution of the disease within the host in the population dynamics of the disease, for one and two infectious agents. We assumed a coupling between the within-host infection rate and the between-host transmission rate. The age of infection within each individual in a population affects the probability of transmission of the disease to a susceptible host and this will affect the temporal evolution of the disease in the host population. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680427183002
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http://dx.doi.org/10.1016/j.idm.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326235PMC
November 2018
2 Reads

Viral dispersal in the coastal zone: A method to quantify water quality risk.

Environ Int 2019 Mar 2;126:430-442. Epub 2019 Mar 2.

School of Natural Sciences, Bangor University, Bangor LL57 2UW, UK; UWA School of Agriculture and Environment, University of Western Australia, Crawley, Australia.

Waterborne and shellfish-borne enteric viruses associated with wastewater-polluted coastal waters (e.g. Norovirus, Hepatitis A/E viruses, Adenovirus) represent a major threat to human health. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.042DOI Listing

Maternal immunisation and neonatal infection of hepatitis A or B virus - Authors' reply.

Lancet Infect Dis 2019 Mar;19(3):238-239

Department of Epidemiology, Brown University School of Public Health, Providence, RI 02903, USA.

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http://dx.doi.org/10.1016/S1473-3099(19)30046-5DOI Listing

Maternal immunisation and neonatal infection of hepatitis A or B virus.

Authors:
Yi-Hua Zhou

Lancet Infect Dis 2019 Mar;19(3):238

Department of Infectious Diseases and Department of Laboratory Medicine, Nanjing Drum Tower Hospital and Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(19)30057-XDOI Listing
March 2019
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Adolescent Immunization Schedule: Need for a Relook.

Indian Pediatr 2019 Feb;56(2):101-104

Mangla Hospital and Research Center, Shakti Chowk, Bijnor, Uttar Pradesh, India. Correspondence to: Dr Vipin M. Vashishtha, Director and Consultant Pediatrician, Mangla Hospital and Research Center, Shakti Chowk, Bijnor, Uttar Pradesh, 246 701, India.

Adolescent immunization is one of the important yet a neglected field in India. There is no adolescent-specific schedule in the government's Universal Immunization Program. Though a separate adolescent immunization schedule exists for the private sector, there is almost no data on the coverage rates of the adolescent vaccines. Read More

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February 2019
2 Reads

The frequency of occurrence anti-HAV antibodies to health employees – own observations

Przegl Epidemiol 2018 ;72(4):453-457

The Tadeusz Browicz Provincial Hospital for Infectious Diseases and Observation in Bydgoszcz

Introduction: In the years 1997-2016, Poland was counted among the countries with a low and very low endemicity of hepatitis A. Based on the epidemiological data from NIZP–PZH (National Institute of Public Health - National Institute of Hygiene), since 2017, an increase in the incidence of hepatitis A has been observed in Poland. Considering the low number of cases by 2016 and a high percentage of seronegative persons, an increased risk of HAV infections should be expected. Read More

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http://dx.doi.org/10.32394/pe.72.4.20DOI Listing
January 2018
1 Read

Hepatitis A in Poland in 2016

Przegl Epidemiol 2018 ;72(4):433-439

National Institute of Public Health – National Institute of Hygiene, Department of Epidemiology of Infectious Diseases and Surveillance

Aim: The aim of this article is to assess the epidemiological situation of Hepatitis A in Poland in 2016 with the regard to the recent years.

Materials And Methods: The assessment was conducted based on the results of the analysis of data from the bulletins “Infectious diseases and poisonings in Poland in 2016” and “Vaccinations in Poland in 2016”, as well as information from the individual case- questionnaires and reports from epidemiological investigations in outbreaks of hepatitis A, submitted by the sanitary-epidemiological stations to the Department of Epidemiology of Infectious Diseases and Surveillance in NIPH-NIH.

Results: In 2016 in Poland there were 35 cases of hepatitis A registered. Read More

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http://dx.doi.org/10.32.394/pe.72.4.18DOI Listing
January 2018
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Severe rhabdomyolysis-induced acute kidney injury following concomitant use of Genvoya® (EVG/COBI/FTC/TAF) and simvastatin; a case report.

BMC Nephrol 2019 Feb 26;20(1):69. Epub 2019 Feb 26.

Department of Internal Medicine, Hôpital du Jura Bernois - Moutier, Rue Beausite 49, 2740, Moutier, Switzerland.

Background: Genvoya® (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide) is a recent single regimen for the treatment of Human Immunodeficiency Virus (HIV). However, because of its complexity, it is difficult to predict drug interactions, especially when associated with HMG-CoA reductase inhibitors and/or in the setting of other comorbidities. We discuss the mechanisms of these potential drug interactions as the cause of rhabdomyolysis and acute kidney injury in the context of prior and current medication therapy with possible underlying liver and kidney dysfunction. Read More

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http://dx.doi.org/10.1186/s12882-019-1257-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390564PMC
February 2019
1 Read

Human health risk assessment for the occurrence of enteric viruses in drinking water from wells: Role of flood runoff injections.

Sci Total Environ 2019 Feb 10;666:559-571. Epub 2019 Feb 10.

Dipartimento di Scienze Biomediche e Oncologia Umana, Università degli Studi Aldo Moro, Bari, Italy.

We demonstrated that floods can induce severe microbiological contamination of drinking water from wells and suggest strategies to better address water safety plans for groundwater drinking supplies. Since 2002, the Italian Water Research Institute (IRSA) has detected hepatitis A virus, adenovirus, rotavirus, norovirus, and enterovirus in water samples from wells in the Salento peninsula, southern Italy. Perturbations in the ionic strength in water flow can initiate strong virus detachments from terra rossa sediments in karst fractures. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.107DOI Listing
February 2019
1 Read

Talk to Patients About: Hepatitis A.

Authors:
Sean Price

Tex Med 2018 May 1;114(5):46. Epub 2018 May 1.

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Clinical experience with the inactivated hepatitis A vaccine, Avaxim 80U Pediatric.

Expert Rev Vaccines 2019 02 26:1-15. Epub 2019 Feb 26.

a Global Medical Affairs , Sanofi Pasteur , Lyon , France.

Introduction: Hepatitis A, caused by hepatitis A virus (HAV), is primarily transmitted via the fecal/oral route either through ingestion of contaminated food and water or through direct contact with an infectious person. Prevalence of hepatitis A is strongly correlated with socioeconomic factors, decreasing with increased socio-economic development, access to clean water and sanitation. Vaccination against HAV should be part of a comprehensive plan for the prevention and control of viral hepatitis, either as part of regular childhood immunization programs or with other recommended vaccines for travelers. Read More

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https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
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http://dx.doi.org/10.1080/14760584.2019.1580578DOI Listing
February 2019
6 Reads

The impact of HIV infection and MSM status on hepatitis A infection: the experience of two tertiary centres in Northern Italy during the 2017 outbreak and in the 2009-2016 period.

J Viral Hepat 2019 Feb 22. Epub 2019 Feb 22.

Infectious Diseases Unit, IRCCS "San Matteo", Pavia, Italy.

Hepatitis A is a self-limiting infection representing the most common cause of viral hepatitis worldwide. Despite being a low incidence region, in the European Union an increasing number of cases have been reported since summer 2016, resulting in a large outbreak in 2017, involving mainly men who have sex with men (MSM). Some reports described a different clinical course of HAV in patients infected by human immunodeficiency virus (HIV) or MSM. Read More

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http://dx.doi.org/10.1111/jvh.13082DOI Listing
February 2019
2 Reads

Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses.

Elife 2019 Feb 25;8. Epub 2019 Feb 25.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, United States.

Many 'non-enveloped' viruses, including hepatitis A virus (HAV), are released non-lytically from infected cells as infectious, quasi-enveloped virions cloaked in host membranes. Quasi-enveloped HAV (eHAV) mediates stealthy cell-to-cell spread within the liver, whereas stable naked virions shed in feces are optimized for environmental transmission. eHAV lacks virus-encoded surface proteins, and how it enters cells is unknown. Read More

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http://dx.doi.org/10.7554/eLife.43983DOI Listing
February 2019
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Viral inactivation of human platelet lysate by gamma irradiation preserves its optimal efficiency in the expansion of human bone marrow mesenchymal stromal cells.

Transfusion 2019 Mar 21;59(3):1069-1079. Epub 2019 Feb 21.

Biotherapy Division, Macopharma, Mouvaux, France.

Background: Human platelet lysate (hPL) represents a powerful medium supplement for human mesenchymal stromal cell (hMSC) expansion. The recently published general chapters of the Pharmacopeia require the addition of a step of viral inactivation during the production process of such raw biological material used for cell-based medicinal products.

Study Design And Methods: The ability of gamma irradiation to inactivate viruses from a panel representative of the virus diversity was evaluated. Read More

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http://dx.doi.org/10.1111/trf.15205DOI Listing

Updates on vaccinating the inflammatory bowel disease patient.

Expert Rev Gastroenterol Hepatol 2019 Mar 21;13(3):229-239. Epub 2019 Jan 21.

b Department of Medicine, Section of Gastroenterology , Boston University School of Medicine , Boston , MA , USA.

Introduction: Many of the therapeutic options for patients with inflammatory bowel disease (IBD) suppress the immune system, which increases the risk of certain infections in these patients. Effective vaccines exist and offer protection against a number of infectious diseases. However, data has shown that IBD patients are inadequately vaccinated and, as a result, are at risk of developing certain preventable infections. Read More

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https://www.tandfonline.com/doi/full/10.1080/17474124.2019.1
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http://dx.doi.org/10.1080/17474124.2019.1565993DOI Listing
March 2019
7 Reads

Phenobarbital-Induced Liver Injury With Nodal Angiomatosis.

Hepatology 2019 Feb 21. Epub 2019 Feb 21.

Department of Pathology, University of Washington School of Medicine, Seattle, WA.

An 18-year-old woman presented with a 2-week history of spiking fever after 3 weeks of daily use of phenobarbital, amoxicillin, chlorpheniramine, ergotamine, and cinnarizine for sinusitis and migraine. She denied animal contact as well as taking ethanol or supplements. Examination revealed enlarged nontender superficial lymph nodes (LNs) in her neck, a normal white blood cell count, atypical lymphocytes of 8. Read More

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http://dx.doi.org/10.1002/hep.30579DOI Listing
February 2019
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Frequency of Hepatotropic Viruses Leading To Deranged Liver Function Tests in Renal Transplant Recipients.

Exp Clin Transplant 2019 01;17(Suppl 1):202-206

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

Objectives: The preferred modality for renal replacement therapy is renal transplantation. Marked improvements in early graft survival and long-term graft function have made renal transplantation a more cost-effective alternative to dialysis. The presence of liver disease in the posttransplant period adversely affects graft function and survival. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P66DOI Listing
January 2019
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Evaluation of Relationship between Occurrence of Liver Cancer and Methylation of Fragile Histidine Triad (FHIT) and P16 Genes.

Med Sci Monit 2019 Feb 18;25:1301-1306. Epub 2019 Feb 18.

Department of Hepatobiliary Surgery, Third Central Hospital of Tianjin (Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry), Tianjin, China (mainland).

BACKGROUND We examined the level of fragile histidine triad (FHIT) and p16 gene methylation in patients with hepatocellular carcinoma and explored the relationship to liver cancer. MATERIAL AND METHODS There were 56 patients with primary liver cancer who were admitted to the hospital from July 2015 to October 2017 included in the liver cancer group, and 24 non-hepatoma patients (hepatitis A/hepatitis B/hepatitis C, liver cirrhosis, liver fibrosis, and fatty liver, alcoholic liver identified as a control group. Fasting venous blood samples were collected from the 2 groups. Read More

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http://dx.doi.org/10.12659/MSM.912315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391852PMC
February 2019
1 Read

Economic evaluation of a publicly funded hepatitis A travel vaccination program in Ontario, Canada.

Vaccine 2019 Mar 13;37(11):1467-1475. Epub 2019 Feb 13.

School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario M5T 1P8, Canada; Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada; Public Health Ontario, 480 University Avenue, Toronto, Ontario M5G 1V2, Canada; Institute for Clinical Evaluative Sciences, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.

Background: Hepatitis A virus (HAV) causes acute liver infection and is spread through the fecal-oral route. Travel to countries in HAV-endemic regions (e.g. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.070DOI Listing
March 2019
1 Read

Vaccination strategies for control of community outbreaks of hepatitis A: A comparison of two outbreaks in England.

Vaccine 2019 Mar 12;37(11):1521-1527. Epub 2019 Feb 12.

Health Protection Team, Public Health England Yorkshire and the Humber, Leeds, UK.

In August 2015 two community outbreaks of hepatitis A virus (HAV) occurred in sub-urban communities in Northern England. Each was managed by an independent outbreak control team. In outbreak one, mass vaccination was deployed targeting a residential area and two schools, while in outbreak two, vaccination was reserved for household-type contacts of cases. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.01.026DOI Listing
March 2019
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Asymptomatic giant cell hepatitis: a subtype of post-infantile giant cell hepatitis?

Clin J Gastroenterol 2019 Feb 14. Epub 2019 Feb 14.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Giant cell hepatitis in adults is considered a rapidly progressive and life-threatening disease, but there are few descriptions of a prolonged disease course. A 36-year-old Japanese man was referred to our hospital for further evaluation of abnormal liver function test results. Although asymptomatic, he had undergone follow-up for 9 years with these abnormalities. Read More

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http://dx.doi.org/10.1007/s12328-019-00950-6DOI Listing
February 2019
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Hepatitis A Virus Prevention and Vaccination Within and Outside the Veterans Health Administration in Light of Recent Outbreaks.

Fed Pract 2018 Mar;35(Suppl 2):S32-S37

is a Fellow in the Division of Gastroenterology and Hepatology at University of North Carolina School of Medicine in Chapel Hill, North Carolina. is a Data Analyst for the HHRC Data and Analytics Group and Data Analyst for Health Services Research and Development at VA Puget Sound Healthcare System. is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration (VHA), Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Infectious Diseases Section at VA Portland Healthcare System in Oregon and an Assistant Professor in the Division of Infectious Diseases at Oregon Health and Sciences University in Portland. Dr. Maier is the National Public Health Infectious Disease Officer. is the Director of the HHRC National Hepatitis Resource Center; Chief, Gastroenterology at VA Long Beach Healthcare System in California; and Professor in the Division of Gastroenterology at University of California, Irvine. is National Program Manager for Prevention Policy at VHA National Center for Health Promotion and Disease Prevention in Durham, North Carolina.

Although widespread hepatitis A vaccination has dramatically decreased infection rates, a large proportion of VA patients in traditionally high-risk groups remains susceptible to infection. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375401PMC
March 2018
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Evidence of sustained reductions in the relative risk of acute hepatitis B and C virus infections, and the increasing burden of hepatitis a virus infection in Egypt: comparison of sentinel acute viral hepatitis surveillance results, 2001-17.

BMC Infect Dis 2019 Feb 14;19(1):159. Epub 2019 Feb 14.

Ministry of Health and Population, Cairo, Egypt.

Background: Egypt ranks fifth for the burden of viral hepatitis worldwide. As part of Egypt's renewed national strategy for the elimination of viral hepatitis, surveillance for acute viral hepatitis (AVH) was re-established during 2014-2017 to describe the current epidemiology and associated risk factors, and changes from surveillance conducted during 2001-2004.

Methods: Patients with suspected AVH were enrolled, completed a questionnaire, and provided blood for testing for hepatitis viruses A (HAV), B (HBV), C (HCV), D, and E (HEV) infections by enzyme-linked immunosorbent assay. Read More

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http://dx.doi.org/10.1186/s12879-019-3806-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376689PMC
February 2019
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Recommendations of the Advisory Committee on Immunization Practices for Use of Hepatitis A Vaccine for Persons Experiencing Homelessness.

MMWR Morb Mortal Wkly Rep 2019 Feb 15;68(6):153-156. Epub 2019 Feb 15.

Hepatitis A (HepA) vaccination is recommended routinely for children at age 12-23 months, for persons who are at increased risk for hepatitis A virus (HAV) infection, and for any person wishing to obtain immunity. Persons at increased risk for HAV infection include international travelers to areas with high or intermediate hepatitis A endemicity, men who have sex with men, users of injection and noninjection drugs, persons with chronic liver disease, person with clotting factor disorders, persons who work with HAV-infected primates or with HAV in a research laboratory setting, and persons who anticipate close contact with an international adoptee from a country of high or interme-diate endemicity (1-3). Persons experiencing homelessness are also at higher risk for HAV infection and severe infection-associated outcomes. Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6806a6.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6806a6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375653PMC
February 2019
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Primary Hepatic Diffuse Large B-cell Lymphoma Mimicking Acute Fulminant Hepatitis: A Case Report and Review of the Literature.

Eur J Case Rep Intern Med 2018 26;5(6):000878. Epub 2018 Jun 26.

Department of Internal Medicine, Middle East Institute of Health, Faculty of Medical Science, Lebanese University, Hadath, Lebanon.

Primary hepatic lymphoma (PHL) is a rare variant of non-Hodgkin's lymphoma. Diffuse hepatic involvement is uncommon and therefore presentation as progressive hepatitis or acute fulminant hepatic failure is rare. Acute onset of signs and symptoms can mimic a variety of infectious and inflammatory disorders, thus delaying the diagnosis. Read More

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http://dx.doi.org/10.12890/2018_000878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346882PMC
June 2018
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Fatal Septic Shock Associated with Herpes Simplex Virus Hepatitis: A Case Report.

Eur J Case Rep Intern Med 2018 27;5(12):000982. Epub 2018 Dec 27.

Intensive Care Unit, Iris South Hospitals, Brussels, Belgium.

Herpes simplex viruses are endemic worldwide, with an estimated seroprevalence of approximately 70% in developed countries. However, it is less well known that they are one of the viral causes of fulminant hepatitis (<2%) and constitute <1% of all causes of acute liver failure. We describe the case of an 89-year-old man who developed sepsis caused by a urinary tract infection due to drug-sensitive . Read More

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http://dx.doi.org/10.12890/2018_000982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346974PMC
December 2018
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Timeliness and completeness of routine childhood vaccinations in young children residing in a district with recurrent vaccine-preventable disease outbreaks, Jerusalem, Israel.

Euro Surveill 2019 Feb;24(6)

Chief Scientist, Ministry of Health, Jerusalem, Israel.

BackgroundChildhood vaccination schedules recommend vaccine doses at predefined ages.AimWe evaluated vaccination completeness and timeliness in Jerusalem, a district with recurrent vaccine-preventable disease outbreaks.MethodsVaccination coverage was monitored by the up-to-date method (vaccination completeness at age 2 years). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.6.1800004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373067PMC
February 2019
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Mineral Waste Containing High Levels of Iron from an Environmental Disaster (Bento Rodrigues, Mariana, Brazil) is Associated with Higher Titers of Enteric Viruses.

Food Environ Virol 2019 Feb 12. Epub 2019 Feb 12.

Microbiology Section, Department of Biotechnology and Food Science, Universidad de Burgos, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain.

Although the effects of heavy metals on the behavior, including infectivity, of bacteria have been studied, little information is available about their effects on enteric viruses. We report an investigation of effects on the biosynthesis of human adenoviruses (HAdV) and hepatitis A (HAV) of waters contaminated with mineral waste following an environmental disaster in Mariana City, Minas Gerais State, Brazil. The study area was affected on November 5, 2015, by 60 million m of mud (containing very high concentrations of iron salts) from a mining reservoir (Fundão), reaching the Gualaxo do Norte River (sites evaluated in this study), the "Rio Doce" River and finally the Atlantic Ocean. Read More

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http://link.springer.com/10.1007/s12560-019-09373-5
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http://dx.doi.org/10.1007/s12560-019-09373-5DOI Listing
February 2019
7 Reads

Epidemiology of viral hepatitis in the Maghreb.

Tunis Med 2018 Oct-Nov;96(10-11):606-619

Introduction: Viral hepatitis represents a serious public health problem in the world especially in the Maghreb where the prevalence of the 5 viruses A, B, C, D, and E remains high and varies from one Maghreb country to another, there is few published studies on these infections in our Maghreb countries.

Method Of Study: Our work is a review of the literature about prevalence, the most common mode of transmission, and the most exposed population for these viruses in the Maghreb countries through published studies between 2011 and 2017.

Result: It has been found that the Maghreb countries are endemic for the five viruses with variable prevalence from one country to another, with sometimes heterogeneous data in the same country. Read More

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February 2019
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Receipt of Preventive Care Services Among US Adults with Inflammatory Bowel Disease, 2015-2016.

Dig Dis Sci 2019 Feb 12. Epub 2019 Feb 12.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Mailstop F-78, 4770 Buford Highway NE, Atlanta, GA, 30341, USA.

Background: Previous reports suggest that adults with inflammatory bowel disease (IBD) receive suboptimal preventive care.

Aims: The population-based study compared the receipt of these services by US adults with and without IBD.

Methods: Adults aged ≥ 18 years with IBD (1. Read More

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http://link.springer.com/10.1007/s10620-019-05494-w
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http://dx.doi.org/10.1007/s10620-019-05494-wDOI Listing
February 2019
4 Reads