26,876 results match your criteria Hepatitis A

HBV vaccination in HIV: immunogenicity and persistence of seroprotection up to 7 years following a primary immunization course.

AIDS Res Hum Retroviruses 2018 Jun 21. Epub 2018 Jun 21.

University of Genoa, Department of Health Sciences- DISSAL, Genoa, Italy.

Objectives: Vaccination against hepatitis B virus (HBV) is recommended in people living with HIV (PLHIV), although immune response rates are lower than in healthy individuals. We aimed at assessing response rates and predictors as well as persistence of seroprotection in a cohort of PLHIV with no serological evidence of current or previous HBV infection.

Methods: PLHIV followed at our site were retrospectively included if they started a primary HBV vaccination course (20 mcg dose three-doses schedule, alone or combined with inactivated hepatitis A virus) between 2007 and 2012. Read More

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Comparative liver transcriptome analysis in ducklings infected with duck hepatitis A virus 3 (DHAV-3) at 12 and 48 hours post-infection through RNA-seq.

Vet Res 2018 Jun 20;49(1):52. Epub 2018 Jun 20.

Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China.

Duck hepatitis A virus 3 (DHAV-3), the only member of the novel genus Avihepatovirus, in the family Picornaviridae, can cause significant economic losses for duck farms in China. Reports on the pathogenicity and the antiviral molecular mechanisms of the lethal DHAV-3 strain in ducklings are inadequate and remain poorly understood. We conducted global gene expression profiling and screened differentially expressed genes (DEG) of duckling liver tissues infected with lethal DHAV-3. Read More

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June 2018
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Hepatitis A, B, and A/B vaccination series completion among US adults: a claims-based analysis.

Hum Vaccin Immunother 2018 Jun 20:1-23. Epub 2018 Jun 20.

b Analysis Group, Inc. , Boston , MA , USA.

Hepatitis A and B disease burden persists in the US. We assessed hepatitis A and hepatitis B vaccination series completion rates among 350,240 commercial/Medicare and 12,599 Medicaid enrollees aged ≥19 years. A vaccination series was considered as completed provided that the minimum interval between doses, as defined by the CDC, and the minimum number of doses were reached. Read More

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Use of gender distribution in routine surveillance data to detect potential transmission of gastrointestinal infections among men who have sex with men in England.

Epidemiol Infect 2018 Jun 20:1-10. Epub 2018 Jun 20.

Field Epidemiology Service,Public Health England,London,UK.

Detecting gastrointestinal (GI) infection transmission among men who have sex with men (MSM) in England is complicated by a lack of routine sexual behavioural data. We investigated whether gender distributions might generate signals for increased transmission of GI pathogens among MSM. We examined the percentage male of laboratory-confirmed patient-episodes for patients with no known travel history for 10 GI infections of public health interest in England between 2003 and 2013, stratified by age and region. Read More

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Inhibition mechanisms of baicalin and its phospholipid complex against DHAV-1 replication.

Poult Sci 2018 Jun 15. Epub 2018 Jun 15.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P R China.

Duck hepatitis A virus type 1 (DHAV-1) is a serious infectious virus of ducklings. Recent study showed baicalin (BA) and baicalin phospholipid complex (BAPC) possessed anti-DHAV-1 effect. However, the antiviral mechanism is not clear. Read More

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Adherence with and completion of recommended hepatitis vaccination schedules among adults in the United States.

Vaccine 2018 Jun 13. Epub 2018 Jun 13.

Merck Sharp & Dohme Corp., a subsidiary of Merck & Co, Inc., Center for Observational and Real-World Evidence (CORE), Vaccines, Kenilworth, NJ, USA.

Introduction: Adult vaccination coverage rates in the US are well below national targets, leaving many adults at increased risk. Additionally, typical vaccination coverage calculations do not adequately approximate population immunity as they do not consider whether multidose vaccines were administered within the recommended schedules. As timely administration of each dose optimizes overall vaccine effectiveness, we sought to document adherence to and completion of the hepatitis A (HepA), hepatitis B (HepB), and combined hepatitis A and hepatitis B (HepA-HepB) multidose vaccine schedule in an insured adult population in the US. Read More

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Response to comment on: Validation of HAV biomarker 2A for differential diagnostic of hepatitis A infected and vaccinated individuals using multiplex serology.

Vaccine 2018 06;36(27):3885

Department of Epidemiology, Helmholtz Centre for Infection Research, Brunswick, Germany. Electronic address:

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Serologic differential diagnosis of hepatitis A virus (HAV) infected and vaccinated individuals: How long persist antibodies to non-structural HAV proteins?

Vaccine 2018 06;36(27):3883-3884

Department of Microbiology and Parasitology, Faculty of Medical Sciences, National Autonomous University, León, Nicaragua. Electronic address:

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Comparative efficacy and tolerability of treatments for adult autoimmune hepatitis: A systematic review and network meta-analysis.

Exp Ther Med 2018 Jun 13;15(6):4838-4850. Epub 2018 Apr 13.

Wenzhou Key Laboratory of Hepatology, Department of Infectious Diseases, Hepatology Institute of Wenzhou Medical University, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

The most suitable treatment regimen for autoimmune hepatitis (AIH) in adults remains unknown and requires further investigation. The current study therefore aimed to integrate evidence to provide hierarchies of the comparative efficacies of treatments measured by clinical and biochemical remission. A Bayesian-framework network meta-analysis of randomized controlled trials (RCTs) was preformed to compare eight treatments for AIH. Read More

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June 2018
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Spillover of a hepatitis A outbreak among men who have sex with men (MSM) to the general population, the Netherlands, 2017.

Euro Surveill 2018 Jun;23(23)

Centre for Infectious Diseases Research, Diagnostics and Screening, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.

Since 2015, outbreaks of hepatitis A among men who have sex with men (MSM) have been reported worldwide. To examine the impact of these MSM outbreaks in the Netherlands, we combined notification and epidemiological data with sequence analysis. Our results show the hazards of outbreaks within risk-groups spilling over into the largely susceptible general population. Read More

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Evidence of hepatitis A virus infection in the patients with acute encephalitis syndrome in Gorakhpur region, North India.

Acta Virol 2018 ;62(2):208-213

The etiological agent remained unidentified in a large number of patients hospitalized for acute encephalitis syndrome (AES) in 2008-2009 in Uttar Pradesh and Bihar, north India. All patients were found to present with fever and altered sensorium, while 28%, 19% and 13% showed hepatomegaly, splenomegaly and meningeal signs, respectively. Involvement mostly of children with abnormal hepatic features prompted us to undertake an exploratory study on viral hepatitis A to determine its association, if any, with hepatic derangements. Read More

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January 2018

Relationship of Severity of Hepatitis A with Polymorphisms in Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Gene.

Ann Hepatol 2018 July - August ,;17(4):561-568

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India Biomedical Informatics Centre, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India.

Introduction And Aim: HAVCR1 protein is the cellular receptor for hepatitis A virus (HAV). Genetic polymorphism in this gene may alter the outcome of HAV infection. In a previous study, a 6-amino acid insertion (157insMTTTVP) in HAVCR1 gene was associated with more severe disease. Read More

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Leucopenia: A Rare Extrahepatic Manifestation of Acute Hepatitis A.

J Clin Exp Hepatol 2018 Jun 8;8(2):215-216. Epub 2018 Jan 8.

Department of Pathology and Transfusion Medicine, Max Super Speciality Hospital, Mussoorie Diversion Road, Malsi, Dehradun, Uttarakhand 248001, India.

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Clinical and virological features of acute hepatitis A during an ongoing outbreak among men who have sex with men in the North of France.

Sex Transm Infect 2018 Jun 9. Epub 2018 Jun 9.

Infectious Diseases Department, Dron Hospital, Tourcoing, France.

Objectives: Since February 2017, an increase of acute hepatitis A (AHA) cases has been notified in North of France. We aimed to report clinical and virological features of 49 cases treated in three hospitals in Lille European Metropolis (LEM).

Methods: All adult patients treated for AHA in 3 LEM hospitals between 20 February and 5 July 2017 were included. Read More

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June 2018
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Family occurrence of autoimmune hepatitis: A Danish nationwide registry-based cohort study.

J Hepatol 2018 Jun 6. Epub 2018 Jun 6.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom. Electronic address:

Background And Aims: It is widely believed that autoimmune hepatitis accumulates in families, but the degree of familial clustering has not been clarified. We conducted a population-based study on the family occurrence of autoimmune hepatitis.

Methods: Through Danish nationwide registries we identified 8,582 first-degree and 9,230 second-degree relatives of index patients diagnosed with autoimmune hepatitis in 1994-2015; and 64 co-twins of index patients diagnosed with autoimmune hepatitis in 1977-2011. Read More

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Causal relationship between acute pancreatitis and methylprednisolone pulse therapy for fulminant autoimmune hepatitis: a case report and review of literature.

J Pharm Health Care Sci 2018 31;4:14. Epub 2018 May 31.

3Department of Pharmacotherapy, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588 Japan.

Background: A causal relationship between acute pancreatitis and administration of glucocorticoids remains a matter of debate, since most of the reported cases were diagnosed with systemic vascular diseases (including systemic lupus erythematosus and polyarteritis nodosa) that may be responsible for the pancreatitis.

Case Presentation: We report a case of a 51-year-old woman who developed acute pancreatitis after receiving methylprednisolone pulse therapy for the treatment of fulminant autoimmune hepatitis (AIH). She was admitted to our hospital because of overt jaundice and back pain. Read More

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May 2018
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Decrease in seroprevalence of hepatitis A virus in Santiago, Chile: A decade-long comparison.

Gastroenterol Hepatol 2018 Jun 2. Epub 2018 Jun 2.

Sección de Gastroenterología, Hospital Clínico Universidad de Chile, Santiago, Chile.

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Travel-associated hepatitis A in Europe, 2009 to 2015.

Euro Surveill 2018 May;23(22)

Karolinska Institutet, Stockholm, Sweden.

BackgroundTravel to countries with high or intermediate hepatitis A virus (HAV) endemicity is a risk factor for infection in residents of countries with low HAV endemicity. The objective of this study was to estimate the risk for hepatitis A among European travellers using surveillance and travel denominator data. We retrieved hepatitis A surveillance data from 13 European Union (EU)/ European Economic Area (EEA) countries with comprehensive surveillance systems and travel denominator data from the Statistical Office of the European Union. Read More

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On the Response of Nanoelectrode Impedance Spectroscopy Measures to Plant, Animal, and Human Viruses.

IEEE Trans Nanobioscience 2018 Apr;17(2):102-109

A simplified lumped geometrical and electrical model for the high-frequency impedance spectroscopy (HFIS) response of nanoelectrodes to capsids and full viruses is developed starting from atomistic descriptions, in order to test the theoretical response of a realistic HFIS CMOS biosensor platform to different viruses. Capacitance spectra are computed for plant (cowpea chlorotic mottle virus), animal (rabbit haemorrhagic disease virus), and human (hepatitis A virus) viruses. A few common features of the spectra are highlighted, and the role of virus charge, pH, and ionic strength on the expected signal is discussed. Read More

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Group C Streptococcal Sore Throat with Hepatitis - a Rare Association.

J Paediatr Child Health 2018 Jun;54(6):708-709

Department of Pediatrics and Neonatology, Royal Bahrain Hospital, Manama, Bahrain.

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June 2018
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[European outbreak of Hepatitis A in Iceland in 2017. Common radiological changes of the gallbladder].

Laeknabladid 2018 Juni;104(6):283-287

Directorate of Health.

IAim The incidence of hepatitis A (HAV) in Iceland is low with about one case per year in the last decades. Since 2016, there has been an ongoing outbreak of HAV in men who have sex with men (MSM). The aim of this study was to inves-tigate whether cases diagnosed in Iceland during 2017 had any link to the HAV outbreak in Europe. Read More

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Acute Liver Failure among Patients on Efavirenz-Based Antiretroviral Therapy.

Case Reports Hepatol 2018 10;2018:1270716. Epub 2018 May 10.

Department of Internal Medicine, Intermediate Hospital Oshakati, Oshakati, Namibia.

Objectives: To describe the clinical characteristics of patients presenting with fulminant liver failure after varying periods of exposure to Efavirenz containing antiretroviral medications.

Methods: We report a series of 4 patients with human immunodeficiency virus (HIV) infection who were admitted with acute liver failure (ALF) over a 6-month period. All these patients had been treated with a range of Efavirenz containing antiretroviral regimens and were negative for hepatitis A, B, and C infections as well as other opportunistic infections, all were negative for autoimmune hepatitis, and none had evidence of chronic liver disease or use of alcohol or herbal medications. Read More

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May 2018
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Development of a Bead-Based Multiplex Assay for the Analysis of the Serological Response against the Six Pathogens HAV, HBV, HCV, CMV, T. gondii, and H. pylori.

High Throughput 2017 Oct 30;6(4). Epub 2017 Oct 30.

NMI Natural and Medical Sciences Institute at the University of Tuebingen, 72770 Reutlingen, Germany.

The spread of infectious diseases and vaccination history are common subjects of epidemiological and immunological research studies. Multiplexed serological assays are useful tools for assessing both current and previous infections as well as vaccination efficacy. We developed a serological multi-pathogen assay for hepatitis A, B and C virus, cytomegalovirus (CMV), , and using a bead-based multiplex assay format. Read More

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October 2017
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Biogeographical ancestry is associated with socioenvironmental conditions and infections in a Latin American urban population.

SSM Popul Health 2018 Apr 17;4:301-306. Epub 2018 Mar 17.

Institute of Collective Health, Federal University of Bahia, Salvador, Bahia, Brazil.

Racial inequalities are observed for different diseases and are mainly caused by differences in socioeconomic status between ethnoracial groups. Genetic factors have also been implicated, and recently, several studies have investigated the association between biogeographical ancestry (BGA) and complex diseases. However, the role of BGA as a proxy for non-genetic health determinants has been little investigated. Read More

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April 2018
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Psychological Disorders and Quality of Life Among Patients With Chronic Viral Hepatitis: A Single-Center Cross-Sectional Study With Pair-Matched Healthy Controls.

Gastroenterol Nurs 2018 May/Jun;41(3):206-218

Nikolaos V. Fotos, PhD, MSc, RN, is Assistant Professor, Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece. Ioannis Elefsiniotis, PhD, is Assistant Professor, Hepatology Unit, University Department of Medicine, General and Oncology Hospital of Kifissia "Agioi Anargyroi," Athens, Greece. Athina Patelarou, PhD, MSc, RN, is with Department of Anesthesiology, University Hospital of Heraklion, Crete, Greece. Konstantinos Giakoumidakis, PhD, MSc, RN, is with Cardiac Surgery Intensive Care Unit, "Evangelismos" General Hospital of Athens, Athens, Greece. Evridiki Patelarou, PhD, MSc, RN, is with Department of Postgraduate Research, Florence Nightingale Faculty of Nursing and Midwifery, King's College London, London, United Kingdom. Andreas Kouros, MSc, RN, is with Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece. Hero Brokalaki, PhD, RN, is Professor, Faculty of Nursing, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

Recent research evidence has shown that patients with chronic viral hepatitis develop symptoms of anxiety and/or depression, which has a strong impact on their health-related quality of life. This study aimed to assess the levels of anxiety, depression, and health-related quality of life among patients with chronic hepatitis B or C in Greece. It was a cross-sectional study among 111 patients with chronic viral hepatitis, evaluated at a tertiary General Hospital of Athens from March to September of 2014. Read More

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Examining Hepatitis, A and B Vaccination, and HBV Reactivation Monitoring During Direct-Acting Antiviral Therapy for Hepatitis C.

J Community Health 2018 May 30. Epub 2018 May 30.

Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

The objective of this study was to examine Hepatitis A (HAV) and Hepatitis B (HBV) screening, and the risk of HBV reactivation during Hepatitis C (HCV) therapy with direct-acting antivirals (DAAs). A retrospective chart review was performed of patients treated with second generation DAA therapy from January 2014 to September 2016 at the Iowa City VA Healthcare System. In total 409 patients initiated HCV treatment, 308 (75%) and 241 (59%) were HAV and HBV vaccine eligible, respectively. Read More

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Hepatitis A: an epidemiological survey in blood donors, France 2015 to 2017.

Euro Surveill 2018 May;23(21)

AP-HP, Hôpital Paul Brousse, Virologie, CNR des Virus des hépatites à transmission entérique, INSERM U1993, Villejuif, France.

Since mid-2016, hepatitis A virus (HAV) outbreaks, involving predominantly men who have sex with men (MSM), have affected countries in Europe and overseas. In France, HAV screening of blood donations in 2017 revealed a HAV-RNA prevalence ca fivefold higher than during 2015-16 (4.42/106 vs 0. Read More

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May 2018
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Adaptive Immune Responses in Hepatitis A Virus and Hepatitis E Virus Infections.

Cold Spring Harb Perspect Med 2018 May 29. Epub 2018 May 29.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's, Columbus, Ohio 43004.

Both hepatitis A virus (HAV) and hepatitis E virus (HEV) cause self-limited infections in humans that are preventable by vaccination. Progress in characterizing adaptive immune responses against these enteric hepatitis viruses, and how they contribute to resolution of infection or liver injury, has therefore remained largely frozen for the past two decades. How HAV and HEV infections are so effectively controlled by B- and T-cell immunity, and why they do not have the same propensity to persist as HBV and HCV infections, cannot yet be adequately explained. Read More

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[Current epidemiological status of causes of disease among patients with liver disease hospitalized in Department of Infectious Diseases in a large general hospital within the past 20 years].

Zhonghua Gan Zang Bing Za Zhi 2018 Feb;26(2):136-141

Department of Infectious Diseases, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China.

To investigate the causes of disease among patients with liver disease hospitalized in Department of Infectious Diseases in our hospital and the changes in such causes within the past 20 years. A retrospective analysis was performed for the clinical data of 7570 patients who were admitted to our hospital from January 1995 to December 2015. The chi-square test was used for the statistical analysis of constituent ratio. Read More

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February 2018

Monkey viral pathology in the Sukhum colony and modeling human viral infections.

J Med Primatol 2018 May 25. Epub 2018 May 25.

Research Institute of Experimental Pathology and Therapy of the Abkhazian Academy of Sciences, Sukhum, Abkhazia.

The data characterizing spontaneous infections of Old World monkeys: measles, poliomyelitis, hepatitis A (HPA), encephalomyocarditis, coronavirus infection, simian hemorrhagic fever (SHF), are presented. The experimental infections were reproduced with the isolated pathogens. On these models, pathogenesis and epidemiology of these diseases were studied. Read More

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Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications.

J Hepatol 2018 May 21. Epub 2018 May 21.

NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK. Electronic address:

A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst. Otherwise, she was only on the oral contraceptive pill and reported minimal alcohol intake. Read More

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Non-invasive messenger RNA transcriptional evaluation in human kidney allograft dysfunction.

Braz J Med Biol Res 2018 17;51(7):e6904. Epub 2018 May 17.

Faculdade de Medicina, Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

The aim of the present study was to evaluate messenger RNA expression in kidney allograft recipients. Forty-four kidney transplant recipients were evaluated up to three months after grafting. After transplantation, peripheral blood samples were drawn sequentially for real-time polymerase chain reaction analyses of perforin and TIM-3 genes. Read More

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Prevalence of non A to E hepatitis in Mumbai, India.

Rev Gastroenterol Peru 2018 Jan-Mar;38(1):49-53

Kasturba Hospital of Infectious Diseases. Mumbai, India.

Introduction: Acute viral hepatitis is a common problem in India. World wide data shows that 5 to 20 percent of this is caused by non A-E hepatitis. There is no data in India regarding non A-E hepatitis. Read More

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May 2018
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Vaccines and the risk of acute disseminated encephalomyelitis.

Vaccine 2018 06 18;36(26):3733-3739. Epub 2018 May 18.

Department of Expanded Program on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, China. Electronic address:

Background: It is important to examine the risk of Acute disseminated encephalomyelitis (ADEM) after vaccination.

Methods: We conducted a nested case-control study between January 2011 and December 2015. Four controls per case were matched for age, gender, address. Read More

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June 2018
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Live attenuated duck hepatitis virus vaccine in breeder ducks: Protective efficacy and kinetics of maternally derived antibodies.

Vet Microbiol 2018 Jun 14;219:107-112. Epub 2018 Apr 14.

Department of Veterinary Infectious Diseases and Avian Diseases, College of Veterinary Medicine and Center for Poultry Diseases Control, Chonbuk National University, South Korea. Electronic address:

Duck viral hepatitis type I is a rapidly spreading infection lethal in young ducklings, caused by the duck hepatitis A virus (DHAV). Vaccination of breeder ducks is a common practice to control DHAV. However, maintaining proper maternal antibody levels in large flocks is difficult. Read More

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June 2018
3 Reads

Human viral pathogens are pervasive in wastewater treatment center aerosols.

J Environ Sci (China) 2018 May 29;67:45-53. Epub 2017 Jul 29.

Université Laval, Pavillon Alexandre Vachon, 1045, ave de la Médecine, Québec, QC G1V0A6, Canada; CRIUCPQ, 2725, Chemin Sainte-Foy, Québec, QC G1V 4G5, Canada. Electronic address:

Wastewater treatment center (WTC) workers may be vulnerable to diseases caused by viruses, such as the common cold, influenza and gastro-intestinal infections. Although there is a substantial body of literature characterizing the microbial community found in wastewater, only a few studies have characterized the viral component of WTC aerosols, despite the fact that most diseases affecting WTC workers are of viral origin and that some of these viruses are transmitted through the air. In this study, we evaluated in four WTCs the presence of 11 viral pathogens of particular concern in this milieu and used a metagenomic approach to characterize the total viral community in the air of one of those WTCs. Read More

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Risk areas for hepatitis A, B and C in the municipality of Maringá, Paraná State, Brazil 2007-2010.

Geospat Health 2018 May 8;13(1):607. Epub 2018 May 8.

Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Paraná.

Viral hepatitis is a major public health problem in Brazil and worldwide. We retrospectively analyzed 338 cases of hepatitis A, B and C in Maringá, Paraná State from 2007 through 2010. The hepatitis A virus was present in 5. Read More

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Hepatitis A virus infection associated with cannabis use.

Can Commun Dis Rep 2017 Nov 2;43(11):245-246. Epub 2017 Nov 2.

National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB.

We identified a case of acute Hepatitis A virus (HAV) infection linked to cannabis use. The local Public Health department received report of a man in his mid-20s with a classic presentation of hepatitis - jaundice, abdominal pain, vomiting, general malaise, and dark urine - as well as elevated serum aminotransferase levels and a positive anti-HAV IgM. Upon questioning, he reported no contact with ill individuals, or travel outside his metropolitan area. Read More

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November 2017

Persistence of Hepatitis A Virus in Fresh Produce and Production Environments, and the Effect of Disinfection Procedures: A Review.

Food Environ Virol 2018 May 14. Epub 2018 May 14.

University of Barcelona, Barcelona, Spain.

Although information is limited, it is evident that prolonged persistence of infectious Hepatitis A virus (HAV) is a factor in the transmission of the virus via fresh produce. Consequently, data on persistence of the virus on produce, and in environments relevant to production, such as soils, water and surfaces, are required to fully understand the dynamics of transmission of HAV via foods. Furthermore, information on effective disinfection procedures is necessary to implement effective post-harvest control measures. Read More

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Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1.

Poult Sci 2018 May 11. Epub 2018 May 11.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P R China.

Duck hepatitis A virus type 1 (DHAV-1) is one of the main pathogens of ducklings and causes a high mortality rate. Baicalin (BA) has potent antiviral effect, but the solubility is very poor. In order to increase the absorption, solubility, and pharmacological activity, the phospholipid complex was used to modify BA in present study. Read More

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Microfluidic PCR Amplification and MiSeq Amplicon Sequencing Techniques for High-Throughput Detection and Genotyping of Human Pathogenic RNA Viruses in Human Feces, Sewage, and Oysters.

Front Microbiol 2018 27;9:830. Epub 2018 Apr 27.

Department of Civil and Environmental Engineering, Tohoku University, Sendai, Japan.

Detection and genotyping of pathogenic RNA viruses in human and environmental samples are useful for monitoring the circulation and prevalence of these pathogens, whereas a conventional PCR assay followed by Sanger sequencing is time-consuming and laborious. The present study aimed to develop a high-throughput detection-and-genotyping tool for 11 human RNA viruses [Aichi virus; astrovirus; enterovirus; norovirus genogroup I (GI), GII, and GIV; hepatitis A virus; hepatitis E virus; rotavirus; sapovirus; and human parechovirus] using a microfluidic device and next-generation sequencer. Microfluidic nested PCR was carried out on a 48. Read More

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Detection of nineteen enteric viruses in raw sewage in Japan.

Infect Genet Evol 2018 May 16;63:17-23. Epub 2018 May 16.

Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:

One-year surveillance for enteric viruses in raw sewage was conducted in Kansai area, central part of Japan from July 2015 to June 2016. The raw sewage was collected monthly from an inlet polluted pool and was concentrated by polyethylene glycol (PEG) precipitation. Twelve sewage samples were screened for nineteen kinds of enteric viruses by using RT-PCR method and further analyzed by nucleotide sequencing. Read More

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May 2018
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Changes in acute viral hepatitis epidemiology in the Turkish adult population: A multicenter study.

Turk J Gastroenterol 2018 03;29(2):177-182

Department of Infectious Diseases and Clinical Microbiology, İstanbul Medeniyet University, Göztepe Training and Research Hospital, İstanbul, Turkey.

Background/aims: The present study aimed to determine the changes in the epidemiology of hepatitis in recent years in an adult Turkish population.

Materials And Methods: Overall, 852 patients with acute viral hepatitis from 17 centers were included in this study. Their sociodemographic characteristics, clinical courses, treatments, and laboratory findings were retrospectively analyzed. Read More

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March 2018
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Genomic Sequence of the WHO International Standard for Hepatitis A Virus RNA.

Genome Announc 2018 May 10;6(19). Epub 2018 May 10.

Division of Virology, National Institute for Biological Standards and Control, South Mimms, United Kingdom

The World Health Organization (WHO) international standard for hepatitis A virus (HAV) RNA nucleic acid assays was characterized by complete genome sequencing. The entire coding sequence and noncoding regions were assigned HAV genotype IB. This information will aid the design, development, and evaluation of HAV RNA amplification assays. Read More

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Expanded table: some vaccines recommended for use in adults.


Med Lett Drugs Ther 2018 May 7;60(1546):e82-e85. Epub 2018 May 7.

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Adult immunization.


Med Lett Drugs Ther 2018 May;60(1546):73-82

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[Changes in Hepatitis A epidemiological pattern in Andalucía: 2007-2017].

Rev Esp Salud Publica 2018 May 9;92. Epub 2018 May 9.

Servicio de Vigilancia y Salud Laboral. Secretaría General de Salud Pública y Consumo. Consejería de Salud. Junta de Andalucía. Sevilla. España.

Objective: Sexual transmission of hepatitis A (HAV) is documented, mainly by risk behaviors in men who have sex with men (MSM). There have been HAV outbreaks in MSM in countries of the European Union in the last years. The aim of this work was to study HAV epidemiology in Andalusia in the last 10 years (2007-2017) and the outbreaks among MSM in this period. Read More

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Clinical and Pathological Characteristics of Autoimmune Hepatitis with Acute Presentation.

Can J Gastroenterol Hepatol 2018 18;2018:3513206. Epub 2018 Mar 18.

Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

To study the differences between acute presentation-autoimmune hepatitis (A-AIH) and chronic autoimmune hepatitis (C-AIH). Through long-term follow-up, 80 patients were included in our study by using the revised international autoimmune hepatitis group (IAIHG) score and were divided into acute and chronic groups for comparison. No significant difference was found in the gender, age, IAIHG score (pretreatment/posttreatment), definite diagnosis rate, extrahepatic autoimmune disease, onset time, or treatment before biopsy between the acute and chronic groups. Read More

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Acute Exacerbation to Autoimmune Hepatitis Mimicking Acute Viral Hepatitis-A Case Series and Review of Literature.

J Clin Exp Hepatol 2018 Mar 1;8(1):98-103. Epub 2017 Sep 1.

Department of Hepatology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Background: Acute exacerbation of Autoimmune Hepatitis (AIH) poses a significant challenge for diagnosis as it can mimic acute viral hepatitis especially in absence of autoantibodies and hypergammaglobulinemia.

Aim: To determine the clinical, laboratory, histopathological characteristics and response to treatment in AIH patients with acute exacerbation.

Methods: A retrospective analysis of 16 patients with acute exacerbation of AIH diagnosed over a period of eight years (2008-2016). Read More

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A Case of Acute-on-Chronic Liver Failure (ACLF) Due to An Uncommon Acute And Chronic Event.

J Clin Exp Hepatol 2018 Mar 1;8(1):95-97. Epub 2017 Sep 1.

Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Acute on Chronic Liver Failure (ACLF) is an acute worsening of patients with chronic liver disease resulting in liver failure. Usually these patients have cirrhosis as the underlying liver disease with alcohol being the most common etiology. Common hepatitic illnesses causing acute worsening in Indian patients of ACLF include alcoholic hepatitis, acute viral hepatitis related to hepatitis E virus and acute flare in chronic hepatitis B. Read More

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