29,371 results match your criteria Hepatitis A

Burden and Trends of Acute Viral Hepatitis in Asia from 1990 to 2019.

Viruses 2022 May 28;14(6). Epub 2022 May 28.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.

Asia has a very high burden of acute hepatitis; thus, a comprehensive study of the current burden and long-term trends of acute hepatitis in Asia is needed. We aimed to assess the current status and trends from 1990 to 2019 of acute hepatitis burden in Asia, using the data from the Global Burden of Diseases Study 2019 (GBD 2019) results. We used the data from the GBD 2019. Read More

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Special Issue "Recent Progress in Hepatitis A Virus Research".

Viruses 2022 May 25;14(6). Epub 2022 May 25.

Virology Laboratory, Hôpital Purpan, CHU Toulouse, 31300 Toulouse, France.

The hepatitis A virus (HAV) is still one of the leading causes of acute viral hepatitis worldwide, despite there being an anti-HAV vaccine [... Read More

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Early childhood education staff are falling through a vaccination policy gap in New Zealand.

N Z Med J 2022 Jan 21;135(1548):96-102. Epub 2022 Jan 21.

Office of Early Childhood Education.

The recent COVID-19 vaccine mandate among early childhood education (ECE) staff highlights the important role ECE staff have in the transmission of infectious diseases. However, there are no data on general vaccine uptake for this group in New Zealand. Additionally, the importance of ECE staff vaccination as a strategy to prevent illness has been rarely promoted in the past, and recommendations for other vaccinations in this group are lacking. Read More

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January 2022

Prevalence of Hepatitis in Prisoners: A Systematic Review of Current Evidence.

Infect Disord Drug Targets 2022 Jun 20. Epub 2022 Jun 20.

MPH Program, Department of Public Health and Community Medicine, Tufts University School of Medicine, United States.

Introduction: Prisoners represent high-risk behaviors such as injecting drug use, sharing syringes, tattooing, and unprotected sexual intercourse. The authors aimed to study the prevalence of hepatitis B, hepatitis C, and hepatitis D in the prisoners.

Methods: We conducted a systematic search using the keywords in online databases of PubMed, Web of Science, Scopus, and Science Direct. Read More

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Development and Characterization of a Nanobody against Human T-Cell Immunoglobulin and Mucin-3.

Comput Math Methods Med 2022 11;2022:2929605. Epub 2022 Jun 11.

The Key Laboratory of Environment and Genes Related to Disease of Ministry of Education, Health Science Center, Xi'an Jiaotong University, Xi'an 710049, China.

Monoclonal antibodies and antibody-derived biologics are essential tools for cancer research and therapy. The development of monoclonal antibody treatments for successful tumor-targeted therapies took several decades. A nanobody constructed by molecular engineering of heavy-chain-only antibody, which is unique in camel or alpaca, is a burgeoning tools of diagnostic and therapeutic in clinic. Read More

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2022 International Autoimmune Hepatitis Group non-response criteria in autoimmune hepatitis: a too early endpoint?

J Hepatol 2022 Jun 15. Epub 2022 Jun 15.

Gastroenterology Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Faculty of Medicine of the University of Porto, Porto, Portugal.

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Method for detecting norovirus, hepatitis A and hepatitis E viruses in tap and bottled drinking water.

Int J Food Microbiol 2022 May 28;377:109757. Epub 2022 May 28.

Université Paris-Est, ANSES, Laboratory for Food Safety, F-94700 Maisons-Alfort, France. Electronic address:

Viruses are a leading cause of foodborne disease worldwide. Human norovirus and hepatitis viruses (hepatitis A (HAV) and hepatitis E (HEV)) are recognised to be the main viruses of importance to public health. The ISO 15216 procedure describes molecular methods for detecting HAV and norovirus in bottled water by using an electropositive filter to concentrate viruses. Read More

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Hepatitis a testing and susceptibility in men who have sex with men: an unintended benefit of PrEP.

Sex Health 2022 Jun 16. Epub 2022 Jun 16.

Hepatitis A is a sexually transmitted enteric infection in men who have sex with men (MSM). HIV pre-exposure prophylaxis (PrEP) has increased opportunities for sexual health interventions in MSM. 588 (372 in 2019, 216 in 2021) MSM attended for the first time in the study periods. Read More

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The relationship between relative telomere length and anti-tuberculosis drug-induced hepatitis : A case-control study.

Therapie 2022 May 25. Epub 2022 May 25.

Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 211166 Nanjing, China. Electronic address:

Aim: Anti-tuberculosis drug-induced hepatitis (AT-DIH) is a common and serious adverse drug reaction of tuberculosis treatment. Evidence demonstrated that many factors could affect the occurrence of AT-DIH, such as ageing, smoking, alcohol, oxidative stress, etc., while these factors could also promote telomere shortening. Read More

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Precancerous cervical lesions caused by non-vaccine-preventable HPV types after vaccination with the bivalent AS04-adjuvanted HPV vaccine: an analysis of the long-term follow-up study from the randomised Costa Rica HPV Vaccine Trial.

Lancet Oncol 2022 Jun 13. Epub 2022 Jun 13.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Background: In women vaccinated against human papillomavirus (HPV), reductions in cervical disease and related procedures results in more women having intact transformation zones, potentially increasing the risk of cervical lesions caused by non-vaccine-preventable HPV types, a phenomenon termed clinical unmasking. We aimed to evaluate HPV vaccine efficacy against cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and cervical intraepithelial neoplasia grade 3 or worse (CIN3+) attributed to non-preventable HPV types in the long-term follow-up phase of the Costa Rica HPV Vaccine Trial (CVT).

Methods: CVT was a randomised, double-blind, community-based trial done in Costa Rica. Read More

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The Italian Mandatory Notification System: An Important Public Health Tool For Continuous Monitoring Of Infectious Diseases.

New Microbiol 2022 04;45(2):115-123

Multi-Specialist Clinical Institute for Orthopaedic Trauma Care (COT), Messina, Italy

Infectious diseases still register significant morbidity and mortality worldwide. Surveillance through a mandatory notification system allows the continuous analysis of the situation even at a local level and its importance has been highlighted by the recent COVID-19 pandemic. This paper aimed to outline the importance of the mandatory notification system as a Public Health tool in the continuous monitoring of infectious diseases. Read More

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Increasing Burden of Acute Hepatitis A among Ethiopian Children, Adolescents, and Young adults: A Change in Epidemiological Pattern and Need for Hepatitis A Vaccine.

Ethiop J Health Sci 2022 Mar;32(2):255-260

Adera Medical Center, Addis Ababa, Ethiopia.

Background: Hepatitis A is a vaccine-preventable, feco-oral infection due to poor sanitary conditions. It is predominantly acquired during early childhood and results in lasting acquired protective immunity. However, it results in severe disease which can end up in acute fulminant hepatitis and hepatic failure when acquired during adolescence and adulthood. Read More

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Editorial: acute severe autoimmune hepatitis-a diagnostic and therapeutic dilemma.

Aliment Pharmacol Ther 2022 07;56(1):170-171

Department of Gastroenterology, Harran University, Şanlıurfa, Turkey.

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Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade.

J Immunother Cancer 2022 Jun;10(6)

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China

Background: Oncolytic viruses (OVs) are capable to inflame the tumor microenvironment (TME) and elicit infiltrating tumor-specific T cell responses. However, OV treatment negatively alters the cancer-immune set point in tumors to attenuate the antitumor immune response, which suggests the necessity of dissecting the immune landscape of the virus-treated tumors and developing novel strategies to maximize the potential of OVs. The aim of this study is to investigate the effect of the single-chain variable fragment (scFv)-armed OVs targeting PD-1 on the TME, and ultimately overcome localized immunosuppression to sensitize tumors to immunotherapies. Read More

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Screening of Hepatitis A and B Seropositivity among Turkish Healthcare Providers Admitted to Occupational Health Services.

Int J Clin Pract 2022 21;2022:6065335. Epub 2022 Feb 21.

University of Health Sciences, Gaziosmanpaşa Taksim Training and Research Hospital, Department of Family Medicine & Occupational Health and Safety Clinic, İstanbul, Turkey.

This study aimed to determine the protection rates against hepatitis A virus (HAV) and hepatitis B virus (HBV), among healthcare providers (HCPs). The occupational health service data of Gaziosmanpaşa Training and Research Hospital between January 2020 and December 2020 were evaluated for this retrospective observational study. Of the 1,722 participants aged 34. Read More

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Nanoemulsions of L. and L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects.

Molecules 2022 Jun 6;27(11). Epub 2022 Jun 6.

Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

Unprecedented nanoemulsion formulations (NE) of and essential oils (EO) were prepared, and examined for their cytotoxic and antiviral activities. NE characterization and stability examination tests were performed to ensure formula stability. The antiviral activity was determined against hepatitis A (HAV) and herpes simplex type-1 (HSV-1) viruses using MTT assay, while the cytotoxic potential was determined against liver (HepG-2), breast (MCF-7), leukemia (THP-1) cancer cell lines and normal Vero cells. Read More

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Evaluation of Potential Anti-Hepatitis A Virus 3C Protease Inhibitors Using Molecular Docking.

Int J Mol Sci 2022 May 27;23(11). Epub 2022 May 27.

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.

Hepatitis A virus (HAV) infection is a major cause of acute hepatitis worldwide and occasionally causes acute liver failure and can lead to death in the absence of liver transplantation. Although HAV vaccination is available, the prevalence of HAV vaccination is not adequate in some countries. Additionally, the improvements in public health reduced our immunity to HAV infection. Read More

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Severe childhood lichen planus pemphigoides after hepatitis A vaccination.

Skin Health Dis 2022 Jun 19;2(2):e94. Epub 2022 Jan 19.

Department of Dermatology Farhat Hached Hospital of Sousse Sousse Tunisia.

Background: Lichen planus (LP) pemphigoides (LPP) is a very rare autoimmune bullous disorder, that is, exceptional in children.

Case Report: We report a case of LP pemphigoides with severe cutaneous and mucosal involvement in an 8-year-old girl who consulted for multiple vesicular and bullous lesions associated with shiny erythematous-purple plaques. The eruption occurred 2 months after vaccination against hepatitis A virus. Read More

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Acute benign pleural effusion, a rare presentation of hepatitis A virus: a case report and review of the literature.

J Med Case Rep 2022 Jun 9;16(1):231. Epub 2022 Jun 9.

Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine.

Introduction: Hepatitis A virus infections are mostly asymptomatic or mildly symptomatic, and generally this disease has a benign course and resolves spontaneously. However, intrahepatic and rarer extrahepatic manifestations can complicate typical cases of acute hepatitis. Pleural effusion is an extremely rare extrahepatic entity with 20 cases reported in literature. Read More

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Aspartate Aminotransferase to Platelet Ratio Index and Fibrosis-4 Index for Detecting Liver Fibrosis in Patients With Autoimmune Hepatitis: A Meta-Analysis.

Front Immunol 2022 18;13:892454. Epub 2022 May 18.

Department of Ultrasound, Chenggong Hospital, Xiamen University, Xiamen, China.

Background: Aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis-4 index (FIB-4) are the two most widely studied noninvasive markers of liver fibrosis. We aimed to assess the diagnostic accuracy of APRI and FIB-4 for liver fibrosis in patients with autoimmune hepatitis (AIH) using liver biopsy as the reference standard.

Methods: PubMed, EMBASE, Cochrane Library and Web of Science databases were searched for studies (published as of May 1st, 2021) that assessed the diagnostic performance of APRI and FIB-4 for liver fibrosis in AIH. Read More

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Preservation of Anti-cytomegalovirus Activity in Human Milk Following High-Pressure Processing Compared to Holder Pasteurization.

Front Nutr 2022 19;9:918814. Epub 2022 May 19.

Translational Medicine Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.

Pasteurized donor human milk is recommended for hospitalized preterm infants when mother's own milk is unavailable. Our aim was to compare the antiviral activity of human milk processed by Holder pasteurization (HoP) or high-pressure processing (HPP) against representative enveloped and non-enveloped viruses including cytomegalovirus and hepatitis A virus. Expressed milk from 20 donors collected from the Ontario Milk Bank was combined into 10 pools, each from two unique donors. Read More

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Associations of different immune checkpoints-expressing CD4 Treg/ T cell subsets with disease-free survival in colorectal cancer patients.

BMC Cancer 2022 Jun 2;22(1):601. Epub 2022 Jun 2.

Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Nizwa, 616, Oman.

There are different subsets of T regulatory cells (Tregs), orchestrating critical roles in the regulation of anti-tumor immunity in colorectal cancer (CRC). In this study, we report that a high frequency of circulating CD4FoxP3 Tregs was associated with poorer disease-free survival (DFS), while their higher frequencies in tumor-infiltrating CD4 Tregs was associated with better DFS. We further investigated such associations with four Tregs/T cells expressing or lacking FoxP3 and Helios (FoxP3Helios). Read More

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[The investigation on the acute, severe hepatitis of unknown origin in children].

Zhongguo Dang Dai Er Ke Za Zhi 2022 Jun;24(6):604-613

National Center for Children's Health/Beijing Children's Hospital, Capital Medical University/Laboratory of Microbiology, Beijing Pediatric Research Institute/National Key Discipline of Pediatrics (Capital Medical University)/Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China.

In April 2022, the United Kingdom notified the World Health Organization (WHO) of an unexpected increase of acute hepatitis of unknown origin in children. Subsequent investigations have found more than 400 cases in more than 20 countries and regions around the world. Although the potential role of adenovirus type 41 in the pathogenesis of these cases is one hypothesis, but it is probably not the only pathogenic factor, and other infectious and non-infectious causes cannot be completely ruled out. Read More

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[Guideline for the investigation of viral hepatitis A outbreak (version 2021)].


Zhonghua Yu Fang Yi Xue Za Zhi 2022 May;56(5):549-553

In China, the incidence rate of Hepatitis A has decreased from 56/100 000 in 1991 to 1.05/100 000 in 2020. The number of Hepatitis A outbreaks in China has decreased significantly, however, it has also happened in the last 5 years, and the risk still remains. Read More

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Analysis of non-severe acute onset autoimmune hepatitis according to the presence of radiological heterogeneity.

Hepatol Res 2022 May 31. Epub 2022 May 31.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Aim: Diagnosis of acute onset autoimmune hepatitis (A-AIH) has been difficult in that patients may not have typical clinicopathological features of AIH. In our previous reports of severe and fulminant AIH, two-thirds of them showed radiological heterogeneity: hepatic heterogeneous hypoattenuation on unenhanced computed tomography (CT) reflecting heterogeneous distribution of massive hepatic necrosis (severe centrilobular necrosis), which would be beneficial for the diagnosis. In the present study, we analyzed non-severe A-AIH patients with or without radiological heterogeneity and tried to find novel clinical features for supporting the early diagnosis. Read More

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National report on healthcare utilization and mortality in patients with hepatitis A infection in the United States.

Public Health 2022 Jun 27;207:113-118. Epub 2022 May 27.

Gastroenterology, Hepatology and Nutrition, The Ohio State Wexner Medical Center, Columbus, OH, USA.

Objectives: Predictors of negative outcomes related to hepatitis A virus (HAV) need to be studied at a national level.

Study Design And Methods: A retrospective analysis using the Nationwide Inpatient Sample (2002-2013) and Nationwide Readmission Database (2010-2014) was performed to evaluate the outcomes of hospitalized patients with HAV. The Nationwide Inpatient Sample and the Nationwide Readmission Database included a varying number of states during the studied time and reflect the range of implementation dates of the HAV vaccines. Read More

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Atypical manifestations of acute viral hepatitis A: Correspondence.

Indian J Gastroenterol 2022 May 30. Epub 2022 May 30.

Dr. DY Patil University, Pune, India.

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Epidemiology of liver failure in Asia-Pacific region.

Liver Int 2022 May 30. Epub 2022 May 30.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

The global burden of deaths caused by liver failure is substantial. The Asia-Pacific region is home to more than half of the global population and accounted for 62.6% of global deaths because of liver diseases in 2015. Read More

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