5,960 results match your criteria Hepatitis E


Hepatitis E Virus Infection and Butchers: A Case-Control Seroprevalence Study.

Gastroenterology Res 2021 Apr 21;14(2):96-103. Epub 2021 Apr 21.

Biomedical Research Laboratory, Faculty of Medicine and Nutrition, Juarez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico.

Background: Very few case-control studies to assess the risk of hepatitis E virus (HEV) infection in meat workers have been published. Therefore, we sought to determine: 1) the association of HEV IgG seropositivity and the occupation of butcher; and 2) the sociodemographic, work, clinical and behavioral characteristics of butchers associated with HEV exposure.

Methods: We performed a case-control seroprevalence study of 101 butchers (mean age: 38. Read More

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Genetic characterizations of Toll-like receptors in the brown rat and their associations with pathogen infections.

Integr Zool 2021 May 18. Epub 2021 May 18.

National Research Center for Wildlife-Borne Diseases, Chinese Academy of Sciences, Institute of Zoology, Beijing, China.

Toll-like receptors (TLRs) are important initiators of innate immune responses that target host-pathogen interactions. However, further research into the molecular characteristics of TLRs in wild populations is required, as well as how TLRs genetically influenced pathogen infections in the brown rat (Rattus norvegicus). Here, we explored the genetic characterization and evolution of 2 sensing nucleic acid TLRs (TLR7 and TLR8) and 2 sensing non-nucleic acid TLRs (TLR2 and TLR4) in the wild brown rat, and assessed their associations with 2 RNA viruses (Seoul hantavirus and rat hepatitis E virus (HEV)) and 2 bacteria (Leptospira and Bartonella). Read More

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Evaluation of hepatitis E antigen kinetics and its diagnostic utility for prediction of the outcomes of hepatitis E virus genotype 1 infection.

Virulence 2021 Dec;12(1):1334-1344

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.

HEV-Ag ELISA assay is a reliable diagnostic test in resource-limited areas. HEV genotype 1 (HEV-1) infections are either self-limited or progress to fulminant hepatic failure (FHF) and death if anti-HEV therapy is delayed. Limited data is available about the diagnostic utility of HEV Ag on HEV-1 infections. Read More

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December 2021

Autochthonous hepatitis E as a cause of acute-on-chronic liver failure and death: histopathology can be misleading but transaminases may provide a clue.

Swiss Med Wkly 2021 Apr 4;151:w20502. Epub 2021 May 4.

Division of Gastroenterology and Hepatology, Lausanne University Hospital and University of Lausanne, Switzerland.

Background And Aim: Acute decompensation and death have been observed in patients with acute hepatitis E virus (HEV) infection and preexisting liver cirrhosis. However, the clinical, laboratory and histological features need to be fully characterised.

Methods: Some of us recently described the histological presentation of hepatitis E in a large panel of liver tissue specimens. Read More

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Deep Insight Into Long Non-coding RNA and mRNA Transcriptome Profiling in HepG2 Cells Expressing Genotype IV Swine Hepatitis E Virus ORF3.

Front Vet Sci 2021 29;8:625609. Epub 2021 Apr 29.

College of Veterinary Medicine, Southwest University, Chongqing, China.

Swine hepatitis E (swine HE) is a new type of zoonotic infectious disease caused by the swine hepatitis E virus (swine HEV). Open reading frame 3 (ORF3) is an important virulent protein of swine HEV, but its function still is mainly unclear. In this study, we generated adenoviruses ADV4-ORF3 and ADV4 negative control (ADV4-NC), which successfully mediated overexpression of enhanced green fluorescent protein (EGFP)-ORF3 and EGFP, respectively, in HepG2 cells. Read More

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Structural and molecular biology of hepatitis E virus.

Comput Struct Biotechnol J 2021 7;19:1907-1916. Epub 2021 Apr 7.

Center for Emerging, Zoonotic and Arthropod-borne Pathogens, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.

Hepatitis E virus (HEV) is one of the most common causes of acute viral hepatitis, mainly transmitted by fecal-oral route but has also been linked to fulminant hepatic failure, chronic hepatitis, and extrahepatic neurological and renal diseases. HEV is an emerging zoonotic pathogen with a broad host range, and strains of HEV from numerous animal species are known to cross species barriers and infect humans. HEV is a single-stranded, positive-sense RNA virus in the family . Read More

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Chronic Hepatitis E With Genotype 1-Masquerading as Allograft Rejection After LiverTransplantation.

J Clin Exp Hepatol 2021 May-Jun;11(3):400-403. Epub 2020 Jul 18.

Department of Hepatology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Hepatitis E is one of the leading causes of acute viral hepatitis worldwide. Chronic infection with hepatitis E is less common and limited to immunosuppressed patients and is usually due to genotype 3 of the virus. Genotype 1, the most prevalent strain in the South Asian region, is seldom known to be associated with chronic hepatitis. Read More

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Current situation of viral hepatitis in Egypt.

Microbiol Immunol 2021 May 15. Epub 2021 May 15.

Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.

An estimated 8-10 million people suffer from viral hepatitis in Egypt. Hepatitis A virus (HAV) and hepatitis E virus (HEV) are major causes of viral hepatitis in Egypt since ≥ 50% of the Egyptian population are already exposed to HAV infection by the age of 15 years. In addition, > 60% of the Egyptian population tested seropositive for anti-HEV in the first decade of life. Read More

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Ivermectin effectively inhibits hepatitis E virus replication, requiring the host nuclear transport protein importin α1.

Arch Virol 2021 Jul 14;166(7):2005-2010. Epub 2021 May 14.

Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Room Na-1005, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

We show that ivermectin, an FDA-approved anti-parasitic drug, effectively inhibits infection with hepatitis E virus (HEV) genotypes 1 and 3 in a range of cell culture models, including hepatic and extrahepatic cells. Long-term treatment showed no clear evidence of the development of drug resistance. Gene silencing of importin-α1, a cellular target of ivermectin and a key member of the host nuclear transport complex, inhibited viral replication and largely abolished the anti-HEV effect of ivermectin. Read More

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Hepatitis E, what is the real issue?

Liver Int 2021 Jun 11;41 Suppl 1:68-72. Epub 2021 May 11.

Service d'hépatologie Hôpital Rangueil CHU Toulouse, Université Paul Sabatier III, Toulouse, France.

Hepatitis E virus (HEV) infection is a worldwide disease and the primary cause of acute viral hepatitis with an estimated 3.3 million symptomatic cases every year and 44,000 related deaths. It is a waterborne infection in the developing countries. Read More

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From hepatitis A to E: A critical review of viral hepatitis.

World J Gastroenterol 2021 Apr;27(16):1691-1715

Transplant Department, Cleveland Clinic Florida, Weston, FL 33331, United States.

Viral infections affecting the liver have had an important impact on humanity, as they have led to significant morbidity and mortality in patients with acute and chronic infections. Once an unknown etiology, the discovery of the viral agents triggered interest of the scientific community to establish the pathogenesis and diagnostic modalities to identify the affected population. With the rapid scientific and technological advances in the last centuries, controlling and even curing the infections became a possibility, with a large focus on preventive medicine through vaccination. Read More

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Cargo encapsulated hepatitis E virus-like particles for anti-HEV antibody detection.

Biosens Bioelectron 2021 Aug 22;185:113261. Epub 2021 Apr 22.

Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka, 422-8529, Japan; Department of Bioscience, Graduate School of Science and Technology, Shizuoka University, 836 Ohya Suruga-ku, Shizuoka, 422-8529, Japan. Electronic address:

Viral capsid-nanoparticle hybrid structures incorporating quantum dots (QDs) into virus-like particles (VLPs) constitute an emerging bioinspired type of nanoarchitecture paradigm used for various applications. In the present study, we packed inorganic QDs in vitro into the hepatitis E virus-like particle (HEV-LP) and developed a fluorometric biosensor for HEV antibody detection. Firstly, for the preparation of QDs-encapsulated HEV-LPs ([email protected]), the HEV-LPs produced by a recombinant baculovirus expression system were disassembled and reassembled in the presence of QDs using the self-assembly approach. Read More

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Resolution of hepatitis E virus infection in CD8+ T cell depleted rhesus macaques.

J Hepatol 2021 May 4. Epub 2021 May 4.

Center for Vaccines and Immunity, The Research Institute at Nationwide Children's, 700 Children's Drive, Columbus, OH, USA; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA. Electronic address:

Background And Aim: HEV is a significant cause of acute hepatitis globally. Some genotypes establish persistent infection when immunity is impaired. Adaptive immune mechanisms that mediate resolution of infection have not been identified. Read More

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Hepatitis E: An update on One Health and clinical medicine.

Liver Int 2021 Jul 19;41(7):1462-1473. Epub 2021 May 19.

Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.

The hepatitis E virus (HEV) is one of the main causes of acute hepatitis and the de facto global burden is underestimated. HEV-related clinical complications are often undetected and are not considered in the differential diagnosis. Convincing findings from studies suggest that HEV is clinically relevant not only in developing countries but also in industrialized countries. Read More

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In silico and in vitro screening of licensed antimalarial drugs for repurposing as inhibitors of hepatitis E virus.

In Silico Pharmacol 2021 4;9(1):35. Epub 2021 May 4.

Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty ofScience, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.

Abstract: Hepatitis E virus (HEV) infection is emerging in Cameroon and represents one of the most common causes of acute hepatitis and jaundice. Moreover, earlier reports showed evidence of falciparum malaria/HEVcoexistence. Although the Sofosbuvir/Ribavirin combination was recently proposed in the treatment of HEV-infected patients, no specific antiviral drug has been approved so far, thereby urging the search for new therapies. Read More

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Guillain-Barré syndrome associated with SARS-CoV-2 infection: A case report with long term follow up.

J Neuroimmunol 2021 07 28;356:577590. Epub 2021 Apr 28.

Laboratory of Gut-Brain Signaling, Laboratory Sciences and Services Division, icddr,b, Dhaka 1212, Bangladesh. Electronic address:

A 50-years old male presented with quadriplegia and paresthesia and was diagnosed as Guillain-Barré syndrome (GBS). He was found positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) six weeks prior to the onset of weakness. GBS disability score was 4. Read More

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Isolation and Characterization of a Subtype 4b of Hepatitis E Virus Using a PLC/PRF/5 cell-derived Cell Line Resistant to Porcine Sapelovirus Infection.

Jpn J Infect Dis 2021 Apr 30. Epub 2021 Apr 30.

Department of Virology II, National Institute of Infectious Diseases, Japan.

A human hepatocarcinoma cell line, PLC/PRF/5, is susceptible to hepatitis E virus (HEV) infection and is used for isolating this virus. It is difficult to use this cell line for the isolation of HEV directly from fecal specimens of swine or wild boar contaminated with porcine sapelovirus (PSV), because PSV infection results in rapid and extensive cytopathic effects in PLC/PRF/5 cells, interrupting the growth of HEV. Herein, we used a PSV infection-resistant cell line, N1380 derived from PLC/PRF/5 cells, and we successfully isolated an HEV-4b strain from a PSV-positive swine fecal specimen. Read More

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Sexual Dimorphism in Hepatocyte Xenograft Models.

Cell Transplant 2021 Jan-Dec;30:9636897211006132

Department of Gastroenterology and Hepatology, 6993Erasmus University Medical Center, Rotterdam, The Netherlands.

Humanized liver mouse models are crucial tools in liver research, specifically in the fields of liver cell biology, viral hepatitis and drug metabolism. The livers of these humanized mouse models are repopulated by 3-dimensional islands of fully functional primary human hepatocytes (PHH), which are notoriously difficult to maintain in vitro. As low efficiency and high cost hamper widespread use, optimization is of great importance. Read More

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Analyses of Clinical and Biological Data for French and Belgian Immunocompetent Patients Infected With Hepatitis E Virus Genotypes 4 and 3.

Front Microbiol 2021 14;12:645020. Epub 2021 Apr 14.

Virology Laboratory, National Reference Centre of Hepatitis E Viruses, Federal Institute of Biology, University Hospital Center, Toulouse, France.

Hepatitis E virus (HEV) genotypes 3 and 4 are the major causes of acute hepatitis in industrialized countries. Genotype 3 is mainly found in Europe and America, while genotype 4 is predominant in Asia. Several Japanese studies have suggested that genotype 4 is more virulent than genotype 3. Read More

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Long-term surveillance for hepatitis E virus in an Italian two-site farrow-to-finish swine farm.

Zoonoses Public Health 2021 May 2. Epub 2021 May 2.

Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.

In humans, hepatitis E virus (HEV) is responsible for an acute enterically transmitted hepatitis, which can become chronic in immune-compromised patients. Genotypes 3 and 4 (HEV-3 and HEV-4) are zoonotic, and domestic pigs and wild boar are the main reservoirs. The occurrence of autochthonous cases in Europe, which have been increasing over the last 10 years, has been associated with food-borne zoonotic transmission of HEV-3, mainly linked to consumption of undercooked or raw pork products (sausages containing liver) and wild boar meat. Read More

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Hepatitis E virus: Whole genome sequencing as a new tool for understanding HEV epidemiology and phenotypes.

J Clin Virol 2021 Jun 27;139:104738. Epub 2021 Jan 27.

MRC-University of Glasgow Centre for Virus Research, Glasgow, UK; Microbiology Department, Laboratoire National de Sante, Dudelange, Luxembourg. Electronic address:

Hepatitis E Virus (HEV) is emerging as a public health concern across Europe and tools for complete genome data to aid epidemiological and virulence analysis are needed. The high sequence heterogeneity observed amongst HEV genotypes has restricted most analyses to subgenomic regions using PCR-based methods, which can be unreliable due to poor primer homology. We designed a panel of custom-designed RNA probes complementary to all published HEV full genome NCBI sequences. Read More

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A surveillance study of hepatitis E virus infection in household cats.

Res Vet Sci 2021 Jul 21;137:40-43. Epub 2021 Apr 21.

Faculty of Veterinary Medicine, Università degli Studi di Teramo, Località Piano D'Accio, 64100 Teramo, Italy.

Hepatitis E virus (HEV) typically causes self-limiting acute viral hepatitis, however chronic infection and extrahepatic manifestations have increasingly become a significant health problem. Domestic pigs and wild boars are the main reservoirs of HEV genotype 3 and genotype 4 for human infections in industrialized countries, although molecular and serological evidence suggest that several additional animal species may act as HEV hosts. In this study, by assessing serologically and molecularly the sera of 324 household cats from Apulia region (Italy), HEV antibodies were detected with an overall prevalence of 3. Read More

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Corpus Callosum Involvement as Extrahepatic Manifestation of Hepatitis E Virus: An Uncommon Entity.

J Neurosci Rural Pract 2021 Apr 1;12(2):427-430. Epub 2021 Apr 1.

Department of Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.

Hepatitis E virus (HEV) is a common cause of acute hepatitis worldwide. HEV infection is not limited only to liver but has various extrahepatic manifestations. Virus can affect various organs like pancreas, lymph nodes, hematological system, kidneys, spleen, central, and peripheral nervous system. Read More

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The Translated Amino Acid Sequence of an Insertion in the Hepatitis E Virus Strain 47832c Genome, But Not the RNA Sequence, Is Essential for Efficient Cell Culture Replication.

Viruses 2021 04 26;13(5). Epub 2021 Apr 26.

German Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589 Berlin, Germany.

The hepatitis E virus (HEV) can cause hepatitis E in humans. Recently, the occurrence of HEV strains carrying insertions in their hypervariable genome region has been described in chronically infected patients. The insertions originate from human genes or from the HEV genome itself. Read More

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Molecular Characterization and Seroprevalence of Hepatitis E Virus in Inflammatory Bowel Disease Patients and Solid Organ Transplant Recipients.

Viruses 2021 04 13;13(4). Epub 2021 Apr 13.

Laboratory of Immunology, Department of Anatomy and Physiology, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.

Seroprevalence rates and molecular characterization of hepatitis E virus (HEV) prevalent in the Lithuanian human population has not yet been evaluated. Immunosuppressed individuals have been recognized as a risk group for chronic hepatitis due to HEV genotype 3 (HEV-3) infections. The objectives of the present study were to determine prevalence rates of anti-HEV antibodies among inflammatory bowel disease (IBD) patients and solid organ transplant (SOT) recipients, to isolate and characterize HEV strain present in the Lithuanian human population, and to investigate its capacity to infect non-human primate (MARC-145 and Vero), swine (PK-15) and murine (Neuro-2a) cells in vitro. Read More

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An outbreak of acute jaundice syndrome (AJS) among the Rohingya refugees in Cox's Bazar, Bangladesh: Findings from enhanced epidemiological surveillance.

PLoS One 2021 29;16(4):e0250505. Epub 2021 Apr 29.

Global Outbreak Alert and Response Network, Geneva, Switzerland.

In the summer of 2017, an estimated 745,000 Rohingya fled to Bangladesh in what has been described as one of the largest and fastest growing refugee crises in the world. Among numerous health concerns, an outbreak of acute jaundice syndrome (AJS) was detected by the disease surveillance system in early 2018 among the refugee population. This paper describes the investigation into the increase in AJS cases, the process and results of the investigation, which were strongly suggestive of a large outbreak due to hepatitis A virus (HAV). Read More

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[Hepatitis E virus replication in intestinal cells: A new facet of this virus revealed].

Med Sci (Paris) 2021 04 28;37(4):320-322. Epub 2021 Apr 28.

Inserm UMR1291/CNRS UMR5051, INFINITY - Institut toulousain des maladies infectieuses et inflammatoires, 31024 Toulouse, France. - CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Institut fédératif de biologie de Purpan, 31059 Toulouse, France.

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Increased homocysteine mediated oxidative stress as key determinant of hepatitis E virus (HEV) infected pregnancy complication and outcome: A study from Northeast India.

Infect Genet Evol 2021 Aug 24;92:104882. Epub 2021 Apr 24.

Department of Biotechnology, Gauhati University, Guwahati, Assam 781014, India. Electronic address:

With the background of association of oxidative stress and Hepatitis E virus (HEV) infection in pregnancy complications the present novel study aimed to evaluate the significance of changes in maternal homocysteine levels and the related mechanism(s) in the pathophysiology of HEV related pregnancy complications and negative outcomes. Term delivery (TD, N = 194) and HEV-IgM positive pregnancy cases [N = 109] were enrolled. Serum and placental homocysteine levels were evaluated by ELISA and immunofluorescence and in turn correlated with serum Vitamin B12 levels. Read More

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Emerging and Re-emerging Infectious Diseases in the WHO Eastern Mediterranean Region, 2001-2018.

Int J Health Policy Manag 2021 Mar 6. Epub 2021 Mar 6.

Department of Primary Care and Public Health, School of Public Health, Faculty of Medicine, Imperial College, London, UK.

Background: Countries in the World Health Organization (WHO) Eastern Mediterranean Region (EMR) are predisposed to highly contagious, severe and fatal, emerging infectious diseases (EIDs), and re-emerging infectious diseases (RIDs). This paper reviews the epidemiological situation of EIDs and RIDs of global concern in the EMR between 2001 and 2018.

Methods: To do a narrative review, a complete list of studies in the field was we prepared following a systematic search approach. Read More

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First description of hepatitis E virus in Australian rabbits.

Aust Vet J 2021 Apr 26. Epub 2021 Apr 26.

Health and Biosecurity, CSIRO, Canberra, Australian Capital Territory, 2601, Australia.

We report the first detection of hepatitis E virus in rabbits in Australia. While conducting metatranscriptomic sequencing of liver samples collected from domestic rabbits that had died, we detected hepatitis E virus in three samples. Two viral genome sequences were obtained, which shared 96% nucleotide identity and clustered with hepatitis E strains isolated from rabbits and humans in Europe. Read More

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