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Clin Exp Nephrol 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiology, St. Marianna University School of Medicine, Kawasaki, Japan.

Purpose: To assess the safety and effectiveness of transcatheter arterial embolization (TAE) with tris-acryl gelatin microspheres for patients with symptomatic enlarged polycystic liver disease (PCLD).

Materials And Methods: This prospective study was approved by our hospital's institutional review board and planned for patients with symptoms related to enlarged PCLD, such as distended abdomen, gastrointestinal obstruction and abdominal pain. Hemi-hepatic embolization with tris-acryl gelatin microspheres was performed in the hepatic artery supplying the hepatic lobe that showed the predominant presence of cysts. Read More

F1000Res 2019 29;8. Epub 2019 Jan 29.

Inherited Renal Disorders, Nephrology Department, Fundació Puigvert, REDINREN, IIB Sant Pau, Universitat Autònoma de Barcelona, Barcelona, 08025, Spain.

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic systemic disorder causing the development of renal and hepatic cysts and decline in renal function. It affects around 1 in 1,000 live births. Early hypertension and progressive renal failure due to massive enlargement of cysts and fibrosis are hallmarks of the disease. Read More

J Toxicol Pathol 2019 Jan 8;32(1):49-55. Epub 2018 Oct 8.

Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.

Adrenal disorders are common in ferrets, but there are few studies on cystic lesions of the adrenal gland. The present study describes pathological and immunohistochemical features of adrenal cysts in eleven ferrets and discusses their histogenesis. In nine of eleven cases examined, which included seven, one, and one right, left, and bilateral cases, respectively, cysts were in the adrenal cortex and lined with epithelial cells. Read More

Ann Parasitol 2018 ;64(4):323-329

Thoracic Surgery, Endoscopic and Minimally Invasive Surgery Research Center, Mashad University of Medical Sciences, Mashad, Iran

Cystic echinococcosis (CE) is a human public health problem in northeast of Iran and there is limited information regarding the genotypes of Echinococcus granulosus senso lato (s.l.) in human in this region. Read More

Radiol Med 2019 Feb 6. Epub 2019 Feb 6.

Radiology Department, University of Health Sciences Umraniye Training and Research Hospital, Adem Yavuz Street. No: 1, Umraniye, 34764, Istanbul, Turkey.

Objective: To investigate the effectiveness of gadoxetic acid-enhanced magnetic resonance cholangiopancreatography (CE-MRCP) and T2-weighted half-Fourier acquisition single-shot turbo spin-echo (T2W HASTE) sequences for diagnosis of cysto-biliary communication in hydatid cysts compared to surgical results.

Methods: Preoperative abdominal magnetic resonance imaging examinations of patients who underwent surgery for hepatic hydatid cysts were reviewed by two radiologists retrospectively. A total of 45 patients with hydatid cysts were included. Read More

J Helminthol 2019 Jan 31:1-5. Epub 2019 Jan 31.

Department of Veterinary Parasitology,DGCN College of Veterinary and Animal Sciences CSK Himachal Pradesh Krishi Vishvavidyalaya Palampur (H.P.),India.

The present study determined the prevalence of hydatid cysts in different organs of slaughtered hilly 'Gaddi' breed small ruminants-sheep (n = 230) and goats (n = 197)-in Kangra Valley of the north-western Himalayas, India. Hydatid cysts were found in 12.2% (n = 28) of sheep and 10. Read More

Parasit Vectors 2019 Jan 24;12(1):57. Epub 2019 Jan 24.

Center for Global Health Tumbes, Universidad Peruana Cayetano Heredia, Tumbes, Peru.

Background: Taenia solium is an important zoonotic parasite that infects humans as definitive host (taeniasis) and pigs as intermediate host (cysticercosis). Serological diagnosis of porcine cysticercosis is limited to antigen detection using ELISA, which is known to cross-react with other Taenia species, and antibody detection using the lentil-lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB), which has not been adequately evaluated for cross-reactivity to other parasites. Field studies suggest that the GP50 diagnostic band of the LLGP EITB may cross-react to Taenia hydatigena, a common non-zoonotic parasitic infection of pigs. Read More

Abdom Radiol (NY) 2019 Jan 21. Epub 2019 Jan 21.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Purpose: This study aimed to evaluate the clinical and radiological findings of hemorrhagic hepatic cysts with enhancing mural nodules.

Methods: The radiology databases of five facilities were retrospectively searched for reports indicating hemorrhagic hepatic cysts or hepatic cystic tumors. Cases of hemorrhagic hepatic cysts with enhancing mural nodules based on pathological or radiological findings were identified and reviewed. Read More

J Vet Diagn Invest 2019 Jan 19:1040638718824736. Epub 2019 Jan 19.

Louisiana Animal Disease Diagnostic Laboratory, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Negrão Watanabe).

Polycystic liver is usually considered an incidental finding in human and veterinary medicine. Two unrelated adult llamas ( Lama glama) with a history of marked anorexia and weight loss were received for autopsy and diagnostic workup. The main gross change in the liver of both animals was multiple variably sized cysts randomly distributed throughout the parenchyma. Read More

Curr Opin Gastroenterol 2019 Mar;35(2):65-72

Department of Gastroenterology and Hepatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

Purpose Of Review: This review provides an outline of the most recent insights and significant discoveries regarding the genetic mechanisms involved in polycystic liver disease.

Recent Findings: Polycystic liver disease includes a heterogeneous group of genetic disorders characterized by multiple hepatic cysts. Isolated liver cysts are caused by mutations in Protein Kinase C Substrate 80K-H (PRKCSH), SEC63, and LDL Receptor Related Protein 5 (LRP5), whereas Polycystic Kidney Disease (PKD)1, PKD2, and PKHD1 mutations cause kidney cysts often accompanied by liver cysts. Read More

BMC Infect Dis 2019 Jan 9;19(1):37. Epub 2019 Jan 9.

Division of General Surgery and Liver Transplantation, POIT Department, San Camillo Hospital - "Lazzaro Spallanzani" National Institute for Infectious Diseases (INMI)-IRCCS, Rome, Italy.

Background: Cystic echinococcosis (CE) is a worldwide zoonosis and the liver is the most commonly affected organ. Clinical manifestations range from completely asymptomatic cysts to a potential lethal cyst rupture and anaphylaxis.

Case Presentation: Severe chest allodynia was an unusual clinical presentation of hepatic cyst rupture in the retroperitoneal space, without any other specific symptoms. Read More

Clin Nucl Med 2019 Jan 4. Epub 2019 Jan 4.

Various etiologies could cause focal I accumulation. Hepatic cyst is one of these etiologies. Here we present a 59-year-old man with a history of papillary thyroid cancer resection who received radioiodine therapy for three times. Read More

Medicine (Baltimore) 2019 Jan;98(1):e13731

Xinjiang Key Laboratory of Echinococcosis, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.

This study aims to evaluate the clinic value of ultrasound, computed tomography (CT) and serological testing in the differentiation between hepatic Cystic Echinococcosis (CE) types 1 and simple hepatic cysts.Totally 50 patients with CE Types 1 and 50 patients with simple hepatic cysts were included. All patients examined by ultrasound, CT and serological testing respectively. Read More

Am J Physiol Renal Physiol 2019 Mar 2;316(3):F463-F472. Epub 2019 Jan 2.

Department of Medicine, The University of Alabama at Birmingham , Birmingham, Alabama.

Heterozygosity for human polycystic kidney and hepatic disease 1 ( PKHD1) mutations was recently associated with cystic liver disease and radiographic findings resembling medullary sponge kidney (MSK). However, the relevance of these associations has been tempered by a lack of cystic liver or renal disease in heterozygous mice carrying Pkhd1 gene trap or exon deletions. To determine whether heterozygosity for a smaller Pkhd1 defect can trigger cystic renal disease in mice, we generated and characterized mice with the predicted truncating Pkhd1 mutation in a region corresponding to the middle of exon 20 cluster of five truncating human mutations (between PKHD1 and PKHD1). Read More

Semin Diagn Pathol 2019 Jan 17;36(1):39-47. Epub 2018 Nov 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Hamartomas and malformations of the liver are rare and can lead to diagnostic challenges. Most present as mass lesions that can mimic true neoplasms of the liver on imaging and sometimes on histology, one example being focal nodular hyperplasia. The primary cell type in the hamartomas and malformations can be biliary, vascular, or hepatic. Read More

JFMS Open Rep 2018 Jul-Dec;4(2):2055116918817631. Epub 2018 Dec 16.

Foundation Hospital Veterinary Clinic, Autonomous Foundation Hospital of Barcelona, Barcelona, Spain.

Case Summary: Congenital or acquired hepatic cystic lesions in cats are a rare condition. Congenital hepatic cysts are often present as part of a systemic polycystic disease involving several organs. Most cats with hepatic cysts remain clinically normal for their lives, although some patients may show abdominal distension, vomiting, abdominal pain and jaundice. Read More

Eur Radiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterology and Hepatology, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Objective: To assess whether quantitative assessment of symptom reduction is a better outcome parameter than cyst volume reduction for treatment success in patients treated by aspiration sclerotherapy.

Methods: We included patients with symptomatic, large (> 5 cm), hepatic cysts from a randomized controlled trial (NCT02048319). At baseline and 6 months after treatment, symptoms were assessed with the polycystic liver disease questionnaire (PLD-Q) and we measured cyst volume using ultrasonography. Read More

Saudi J Biol Sci 2018 Nov 9;25(7):1375-1379. Epub 2018 Apr 9.

Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.

Hydatidosis is considered to be one of the important zoonotic diseases and has a significant public health importance due to the difficulties of the diagnosis. Domestic animals act as intermediate hosts and the main reservoir for the disease in humans. The main purpose of this work therefore was to determine the prevalence of hydatidosis in Najdi sheep slaughtered in Riyadh city, Saudi Arabia. Read More

PLoS One 2018 5;13(12):e0207880. Epub 2018 Dec 5.

Department of Radiology, Seoul National University Hospital, Seoul, Korea.

Purpose: To investigate the imaging features of cyst infection in autosomal dominant polycystic kidney disease (ADPKD) patients using computed tomography (CT) and ultrasonography (US).

Materials & Methods: The institutional review board approved this retrospective study. Fifty-one episodes with proven cyst infection in forty-three ADPKD patients were included. Read More

Immunol Res 2018 Nov 29. Epub 2018 Nov 29.

Unit of Infectious and Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy.

Cystic echinococcosis (CE) is a neglected helminthic zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus s.l. MicroRNAs (miRNAs) are regulators of gene expression that have been linked with the pathogenesis of several human diseases, but little exists in the available literature about miRNAs in CE. Read More

Mymensingh Med J 2018 Oct;27(4):869-871

Dr Fahima Akter Dowel, Medical Officer, Institute of Nuclear Medicine and Allied Sciences (INMAS), Mymensingh, Bangladesh.

Hepatic hydatid disease is a goonotic disease caused by Echinococcus granulosus and it is endemic in different parts of the world. This infection is an important public health problem. Although it is distributed throughout the world but common in the livestock grazing regions of the world such as in Central Europe, Africa, South America, Central Asia and China. Read More

Ann R Coll Surg Engl 2018 Nov 28:e1-e2. Epub 2018 Nov 28.

Department of Surgery, Tallaght University Hospital , Dublin , Ireland.

Cysts in the liver have a wide variety of aetiologies. Important features of malignancy based on various imaging techniques must be considered prior to any intervention. Perioperative decision making in complex or difficult cysts is key to appropriate patient management. Read More

Eur J Radiol Open 2018 15;5:209-214. Epub 2018 Nov 15.

The Canberra Hospital, Garran, ACT 2606, Australia.

Purpose: The aim of this project is to investigate the usefulness of the absolute liver lesion ADC value and ratio of Apparent diffusion coefficient (ADC) values of a liver lesion and liver parenchyma to discriminate between a benign and malignant lesion.

Methods: Liver MRI scans performed between January 2009 and June 2015 were retrospectively analysed. Scans were performed on either a 1. Read More

Turk J Surg 2018 Nov 20:1-3. Epub 2018 Nov 20.

Department of Surgical Gastroenterology, King George's Medical University School of Medicine, Lucknow, India.

Hydatid disease is a parasitic zoonosis caused by the larval form of the Echinococcus worm. Hepatic hydatidosis is the most common form of disease in humans. Centrally located, large hydatid cysts have the tendency to rupture into the adjoining bile duct and form a fistulous communication. Read More

J Antimicrob Chemother 2019 Mar;74(3):829-830

Department of Gastroenterology and Hepatology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Ann Med Surg (Lond) 2018 Dec 2;36:99-105. Epub 2018 Nov 2.

Dept. of Paediatric Surgery, PGIMS Rohtak, Haryana, India.

Cystic echinococcosis (CE) is a widely endemic helminthic disease caused by infection with metacestodes (larval stage) of the Echinococcus granulosus tapeworm and transmitted by dogs. are common parasites in certain parts of the world, and are present on every continent with the exception of Antarctica. As a result, a large number of people are affected by CE. Read More

Asian J Surg 2018 Nov 13. Epub 2018 Nov 13.

Department of Surgery, Hadassah-Hebrew University Medical Center, Ein Kerem, Israel. Electronic address:

Background: Hydatid cyst is a zoonotic disease caused by Echinococcus genera. Surgery is needed in most cases. We aimed to describe our center's experience in the surgical management of hepatic hydated cysts (HHC). Read More

Transplantation 2018 Nov 15. Epub 2018 Nov 15.

Département de Chirurgie Hépato-pancréato-biliaire, AP-HP Hôpital Beaujon, Clichy, France.

Background: Liver transplantation (LT) for polycystic liver disease (PLD) is rare, extremely challenging and hemorrhagic, without standard approach. Moreover, LT for PLD presents the highest mortality rate (12 to 18%) among all causes of LT. In this setting, the combination of difficult mobilization of a heavy polycystic native liver with narrow access to inferior vena cava (IVC) and fragile venous wall may lead to venous tearing and cataclysmic bleeding during dissection. Read More

Pediatrics 2018 Dec 14;142(6). Epub 2018 Nov 14.

Drinković Polyclinic, Zagreb, Croatia.

Because of mostly asymptomatic cyst growth and often-neglected nonspecific low-grade symptoms, many cases of cystic echinococcosis (CE) caused by in the pediatric population are diagnosed at school age, in an advanced and even complicated stage. In 2003, after 5 months of intermittent dull upper-right abdominal pain and nausea, a 13-year-old boy was diagnosed with massive liver CE, with ∼20 round-shaped double-walled medium-sized infective cysts, which permeated the whole liver. Because of their wide distribution across the liver tissue and the risky superficial position of some cysts, liver transplantation emerged as the optimal therapeutic option. Read More

Am J Trop Med Hyg 2019 Jan;100(1):143-145

Department of Health Sciences, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.

We report the case of an adolescent Moroccan girl with abdominal pain and palpable mass in the upper right side of the abdomen. In the emergency department, an abdominal ultrasound showed hepatomegaly and eight active liver cysts, compatible with cystic echinococcosis. Serology for confirmed the diagnosis. Read More

Am J Trop Med Hyg 2018 Nov;99(5):1107

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Comp Immunol Microbiol Infect Dis 2018 Oct 13;60:23-27. Epub 2018 Oct 13.

Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:

Plant-based anthelmintics suggest an alternative treatment for cystic echinococcosis. The present study was conducted to evaluate the efficacy of methanolic extract (ME) of A. sativum (garlic) on the treatment of hydatid cysts in the murine model. Read More

J Obstet Gynaecol Res 2019 Feb 4;45(2):477-481. Epub 2018 Nov 4.

Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, Naples, Italy.

We describe the case of a childbearing-age woman presenting with spontaneous recurrent functional ovarian cysts and, more interestingly, chronic and asymptomatic elevation of cholestatic parameters. The patient showed no history of chronic viral infections, immunological and metabolic disorders, alcohol abuse and environmental toxins exposition. Hepatic ultrasonography and cholangio-pancreatography-magnetic-resonance excluded any morphological and structural abnormalities, while liver biopsy evidenced only minimal and not specific features of inflammation. Read More

Hum Mol Genet 2018 11 1. Epub 2018 Nov 1.

Telethon Institute of Genetics and Medicine (TIGEM),Via Campi Flegrei, 34, 80078, Pozzuoli, Naples, Italy.

Primary cilia are hair-like organelles that play crucial roles in vertebrate development, organogenesis, and when dysfunctional result in pleiotropic human genetic disorders called ciliopathies, characterized byoverlapping phenotypes, such as renal and hepatic cysts, skeletal defects, retinal degeneration, and CNS malformations. Primary cilia act as communication hubs to transfer extracellular signals into intracellular responses and are essentialfor Hedgehog (Hh) signal transduction in mammals. Despite the renewed interest in this ancient organelle of growing biomedical importance, the molecular mechanisms that trigger cilia formation, extension and ciliary signal transduction are still not fully understood. Read More

J Med Genet 2018 Nov 1. Epub 2018 Nov 1.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Copa syndrome is a rare autosomal dominant disorder with abnormal intracellular vesicle trafficking. The objective of this work is to expand the knowledge about this disorder by delineating phenotypic features of an unreported COPA family.

Methods And Results: A heterozygous missense variant (c. Read More

J Med Life 2018 Jul-Sep;11(3):203-209

"Carol Davila" Medical University, Bucharest.

the hydatic disease, caused by the larvae of Echinococcus granulosus, is a serious disease, potentially lethal, which can be found anywhere in the world, but especially in endemic areas such as the Mediterranean Basin, Australia, New Zealand, North Africa, Eastern Europe, the Balkans, Middle East and South America. The hydatic cyst is mainly found in the liver (75% of the cases), being asymptomatic in most cases and discovered accidentally on a routine abdominal ultrasound or an ultrasound performed for diagnosing other pathologies. The hepatic hydatid cyst therapy is multimodal, including medical, surgical, and, lately, minimally invasive techniques. Read More

Antimicrob Agents Chemother 2019 Jan 21;63(1). Epub 2018 Dec 21.

State Key Laboratory of Pathogenesis, Prevention, and Treatment of Central Asian High Incidence Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China

Cystic echinococcosis is a zoonosis caused by the larval stage of There is an urgent need to develop new drugs for the treatment of this disease. In this study, we identified two new members of mitogen-activated protein kinase (MAPK) cascades, MKK3/6 and MEK1/2 homologs (termed EgMKK1 and EgMKK2, respectively), from Both EgMKK1 and EgMKK2 were expressed at the larval stages. As shown by yeast two-hybrid and coimmunoprecipitation analyses, EgMKK1 interacted with the previously identified Egp38 protein but not with EgERK. Read More

Clin J Gastroenterol 2018 Oct 20. Epub 2018 Oct 20.

Human Stem Cells Institute, Moscow, Russia.

Herein we present a clinical case of the Caroli syndrome caused by the compound heterozygous mutation in the PKHD1 gene. Histopathological assessment of liver detected biliary cirrhosis, numerous dilated bile ducts of various sizes, hyperplastic cholangiocytes containing a large amount of acid mucopolysaccharides, decreased ß-tubulin expression and increased proliferation of cholangiocytes. A significant proportion of hepatic tissue was composed of giant cysts lined with a single layer of cholangiocytes, containing pus and bile in its lumen and surrounded by granulation tissue. Read More

Ann Ital Chir 2018 ;89:309-314

Objectives: The liver is the most frequent anatomic location of hydatid disease. Imaging modality nowadays are numerous and increasingly efficient. The objective of our study is to precise the correlation between Ultrasonography, computed tomography and intraoperative findings on the different characteristics of hepatic hydatid cyst. Read More

J Pediatr Gastroenterol Nutr 2019 Feb;68(2):161-168

Department of Health Sciences, University of Florence, Anna Meyer Children's University Hospital, Florence, Italy.

Among parasitic hepatic cystic lesions, the most common disease is represented by cystic echinococcosis (CE), especially in high endemic countries. European epidemiology of CE in children is difficult to assess because of under-reporting but is increasing, because of high immigration flows from endemic countries and an increased awareness. Hydatidosis can be localized in every part of the body. Read More

J Endocrinol 2018 Dec;239(3):325-338

Laboratorio de Alteraciones Reproductivas y Metabólicas, Centro de Neurobiología y Plasticidad Cerebral (CNPC), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Maternal obesity causes a wide range of impairment in offspring, such as metabolic and reproductive dysfunctions. We previously demonstrated that female offspring of obese rats have increased serum estradiol levels during early postnatal life, probably because of decreased hepatic cytochrome P450 3A2 levels, which could lead to early onset of puberty and polycystic ovary condition in adulthood. Using metformin during pregnancy and nursing to improve the metabolic status of obese mothers could prevent the sequence of events that lead to an increase in postnatal serum estradiol levels in female offspring and, hence, reproductive dysfunction. Read More

Surg Endosc 2019 Mar 17;33(3):691-704. Epub 2018 Oct 17.

Department of Gastroenterology and Hepatology, Radboudumc, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Background: Laparoscopic fenestration is one of the treatment options for symptomatic hepatic cysts, either solitary or in context of polycystic liver disease (PLD), but indications, efficacy and surgical techniques are under debate.

Methods: A systematic literature search (1950-2017) of PubMed, Embase, Web of Science and the Cochrane Library was performed (CRD42017071305). Studies assessing symptomatic relief or symptomatic recurrence after laparoscopic fenestration in patients with symptomatic, non-parasitic, hepatic cysts were included. Read More

Korean J Gastroenterol 2018 Sep;72(3):146-149

Departments of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

An 88-year-old woman complained of right quadrant abdominal pain and severe edema in both legs. She had a history of pulmonary embolism one month ago. Abdomen CT showed a huge hepatic cyst compressing the intrahepatic portion of the inferior vena cava (IVC). Read More

J Coll Physicians Surg Pak 2018 Oct;28(10):801-803

Department of Internal Medicine, Abant Izzet Baysal University (AIB), Bolu, Turkey.

Hydatid cyst is a parasitic infection which causes enormous morbidity and mortality worldwide. The pathogenic organism responsible for hydatid cyst is Echinococcus granulosus. Despite the fact that the characteristic cysts of the disease usually occur in liver and lungs, they may also occur in aberrant localisations. Read More

Arch Razi Inst 2018 Dec 17;73(1):61-67. Epub 2017 Mar 17.

Department of Pathology, Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization, Karaj, Iran.

The present study aimed to investigate whether sphingosine 1 phosphate (S1P), paraoxonase (PON), total sialic acid (TSA), and heat shock protein-27 (HSP27) are altered in the sheep during infection of the liver with Cysticercus tenuicollis. This study was conducted on40 healthy sheep and40 sheep with Cysticercus tenuicollis infection. The infected and non-infected animals were selected based on the observation of severe Cysticercus tenuicollis infection in the liver and absence of any hepatic cysts, respectively. Read More

Maturitas 2018 Oct 4;116:1-7. Epub 2018 Jul 4.

Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece.

Objective: Visceral adiposity index (VAI), initially developed for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD); however, its diagnostic performance for NAFLD is still under investigation. We evaluated VAI as a marker of NAFLD and compared its diagnostic performance with that of three other NAFLD indices - fatty liver index (FLI), lipid accumulation product (LAP) and hepatic steatosis index (HSI) - in premenopausal women with and without polycystic ovary syndrome (PCOS) assessed for NAFLD by ultrasonography.

Design: Cross-sectional case-control study. Read More

PLoS One 2018 20;13(9):e0204073. Epub 2018 Sep 20.

Pathology Research Unit, Finnish Food Safety Authority, Evira, Helsinki, Finland.

Ciliopathies presenting as inherited hepatorenal fibrocystic disorders are rare in humans and in dogs. We describe here a novel lethal ciliopathy in Norwich Terrier puppies that was diagnosed at necropsy and characterized as diffuse cystic renal disease and hepatic fibrosis. The histopathological findings were typical for cystic renal dysplasia in which the cysts were located in the straight portion of the proximal tubule, and thin descending and ascending limbs of Henle's loop. Read More

J Magn Reson Imaging 2019 Mar 19;49(3):894-903. Epub 2018 Sep 19.

Department of Radiology, Weill Cornell Medicine, New York, New York, USA.

Background: Autosomal dominant polycystic kidney disease (ADPKD) can involve prostate and seminal vesicles but the potential interrelationship of these findings and associations with PKD gene mutation locus and type is unknown.

Purpose: To determine the interrelationship of seminal megavesicles (seminal vesicles with lumen diameter > 10mm) and prostatic cysts in ADPKD and to determine whether there are associations with PKD gene mutations.

Study Type: Retrospective, case control. Read More