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Infect Dis Ther 2022 Jun 25. Epub 2022 Jun 25.

Department of General Surgery, The General Hospital of Western Theater command, Chengdu, 610083, People's Republic of China.

Liver echinococcosis is clinically mainly composed of hepatic cystic echinococcosis (CE) and hepatic alveolar echinococcosis (AE). At present, laparoscopy has been comprehensively applied in the treatment of two types of liver echinococcosis. For hepatic CE treatment, both laparoscopic total pericystectomy and laparoscopic hepatectomy can achieve radical results, but the former is considered the first choice owing to its being more minimally invasive; laparoscopic subtotal pericystectomy and laparoscopic partial pericystectomy can be accepted as complementary options, considering the presence of complicated cysts and the level of laparoscopic technique in remote hospitals; laparoscopic cystectomy is simple, but it is not currently recommended for treatment of hepatic CE owing to poor efficacy and high risk of postoperative complications. Read More

Genes (Basel) 2022 Jun 8;13(6). Epub 2022 Jun 8.

Faculty of Medicine, Macau University of Science and Technology, Macau, China.

Choledochal cysts (CC) is characterized by extra- and/or intra-hepatic b\ile duct dilations. There are two main theories, "pancreaticobiliary maljunction" and "congenital stenosis of bile ducts" proposed for the pathogenesis of CC. Although family cases or CC associated with other anomalies have been reported, the molecular pathogenesis of CC is still poorly understood. Read More

J Endocr Soc 2022 Aug 15;6(8):bvac087. Epub 2022 Jun 15.

Department of Diabetology, Hôpital Cochin, APHP, and Université Paris Cité, Paris, France.

Hepatocyte nuclear factor-1B (HNF1B) maturity-onset diabetes of the young (MODY), also referred to as "renal cysts and diabetes syndrome" or MODY-5, is a rare form of monogenic diabetes that is caused by a deletion or a point mutation in the HNF1B gene, a developmental gene that plays a key role in regulating urogenital and pancreatic development. HNF1B-MODY has been characterized by its association with renal, hepatic and other extrapancreatic features. We present the case of a 39-year-old female patient who was first diagnosed with type 1 diabetes, but then, owing to the absence of anti-islet autoantibodies and to the disease's progression, was labeled later on as having atypical type 2 diabetes. Read More

J Minim Access Surg 2022 Jul-Sep;18(3):360-365

Department of Paediatric Surgery, GMC, Srinagar, Jammu and Kashmir, India.

Background: : Surgery continues to be the mainstay of treatment of hydatid cysts of the liver. Laparoscopy provides a lesser invasive tool for achieving results same as with the established open surgical techniques. The purpose of the study was to evaluate the feasibility and safety of laparoscopic management of hepatic hydatid disease in children. Read More

Front Microbiol 2022 30;13:902855. Epub 2022 May 30.

Department of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.

The global distribution of breast cancer and the opportunistic nature of the parasite have resulted in many patients with breast cancer becoming infected with toxoplasmosis. However, very limited information is available about the potential effects of tamoxifen on chronic toxoplasmosis and its contribution to the reactivation of the latent infection. The present study investigated the potential effects of tamoxifen on chronic toxoplasmosis in animal models (Swiss albino mice). Read More

Transl Cancer Res 2022 May;11(5):1230-1244

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, China.

Background: With advances in technology and medical treatment, laparoscopy is increasingly used in hepatic cyst surgery. We hope that the analysis the safety and efficacy of laparoscopic hepatectomy versus open hepatectomy in giant hepatic cyst surgery will provide a theoretical basis for the choice of treatment means for clinicians.

Methods: By searching CNKI (China National Knowledge Infrastructure), Wanfang, VIP (China Science and Technology Journal Database), CBM (China Biology Medicine disc), PubMed, Embase and Cochrane Library databases, all Chinese- and English-language articles on the safety and efficacy of laparoscopic hepatectomy and open hepatectomy for hepatic cysts were collected from database establishment to December 2021. Read More

Asian J Surg 2022 May 31. Epub 2022 May 31.

Department of Hepatobiliary Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, NO.91 Tianchi Road, Urumqi, 830011, China. Electronic address:

Object: The clinical efficacy of robot-assisted laparoscopic pericystectomy using the Da Vinci Xi surgical system plus indocyanine green（ICG） fluorescence imaging and the conventional laparotomy for en bloc pericystectomy was compared.

Methods: The clinical data of 7 patients treated by robot-assisted laparoscopic pericystectomy using the Da Vinci Xi surgical system plus ICG fluorescence imaging at our hospital between October 2019 and July 2021 and 15 patients treated by conventional laparotomy for en bloc pericystectomy were retrospectively analyzed.

Result: Compared with the conventional laparotomy group, the intraoperative blood loss was reduced using the Da Vinci surgical system [(225. Read More

J Minim Access Surg 2022 Jun 2. Epub 2022 Jun 2.

Department of Paediatric Surgery, GMC, Srinagar, Jammu and Kashmir, India.

Background: : Surgery continues to be the mainstay of treatment of hydatid cysts of the liver. Laparoscopy provides a lesser invasive tool for achieving results same as with the established open surgical techniques. The purpose of the study was to evaluate the feasibility and safety of laparoscopic management of hepatic hydatid disease in children. Read More

Ear Nose Throat J 2022 May 31:1455613221106220. Epub 2022 May 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Habib Bourguiba University Hospital, Sfax, Tunisia.

Langerhans Cell Histiocytosis is a rare disorder characterized by an abnormal proliferation of Langerhans cells in one or multiple organs. It rarely presents with a central vestibular involvement. We report a case of a multisystem Langerhans Cell Histiocytosis with mucosal, hepatic, and neurological involvement, presenting with dizziness and balance disorders. Read More

J Int Med Res 2022 May;50(5):3000605221100768

Department of Pathology, Fuyang Tumour Hospital, Fuyang, Anhui Province, China.

Primary hepatic stromal tumours are very rare and there are only sporadic reports in the literature. Due to the lack of specificity in their clinical manifestations and imaging features, these tumours are easily misdiagnosed. This current report presents a case of primary liver stromal tumour that was misdiagnosed as a liver cyst. Read More

J Minim Invasive Surg 2021 Sep;24(3):165-168

Department of Medicine, DR. D. Y. Patil Medical College and Hospital, Kolhapur, India.

Hydatid disease is a zoonosis caused by a parasite, , characterized by a cystic lesion in the liver, lung, or (rarely) in other parts of the body. Typical radiological findings make the diagnosis easy and help the surgeons to plan the management of hydatid disease. We report a case of giant hepatic hydatid cyst in a 12-year-old boy who presented with epigastric swelling and pain for 6 months. Read More

Clin Case Rep 2022 May 18;10(5):e05897. Epub 2022 May 18.

Department of Public Health and Healthcare I. K. Akhunbaev Kyrgyz State Medical Academy Bishkek Kyrgyzstan.

A 37-year-old woman was diagnosed with concurrent pulmonary and hepatic hydatid cysts. We performed simultaneous resection of hydatid cysts in the liver and right lung using a single-stage surgical procedure. The patient completely recovered. Read More

FASEB J 2022 06;36(6):e22364

Department of Molecular Medicine (DMM), University of Padova, Padova, Italy.

Congenital hepatic fibrosis (CHF), a genetic cholangiopathy characterized by fibropolycystic changes in the biliary tree, is caused by mutations in the PKHD1 gene, leading to defective fibrocystin (FPC), changes in planar cell polarity (PCP) and increased β-catenin-dependent chemokine secretion. In this study, we aimed at understanding the role of Scribble (a protein involved in PCP), Yes-associated protein (YAP), and β-catenin in the regulation of the fibroinflammatory phenotype of FPC-defective cholangiocytes. Immunohistochemistry showed that compared with wild type (WT) mice, in FPC-defective (Pkhd1 ) mice nuclear expression of YAP/TAZ in cystic cholangiocytes, significantly increased and correlated with connective tissue growth factor (CTGF) expression and pericystic fibrosis, while Scribble expression on biliary cyst cells was markedly decreased. Read More

ANZ J Surg 2022 06 17;92(6):1356-1364. Epub 2022 May 17.

Department of Surgery, North Shore Hospital, Auckland, New Zealand.

Background: Choledochal cysts should be treated with complete surgical resection, or, rarely liver transplantation. Treated patients can remain at risk of developing metachronous cholangiocarcinomas and lifelong follow up is indicated. However, there is no agreement on what constitutes an acceptable follow up strategy. Read More

Rev Bras Ginecol Obstet 2022 Mar 16;44(3):287-294. Epub 2022 May 16.

Department of Gynecology, Universidade Federal do Ceará, Fortaleza, CE, Brazil.

Objective:  To evaluate the association between polycystic ovary syndrome (PCOS) and metabolic syndrome (MetS), adding liver assessment through elastography and ultrasound, for correlation with non-alcoholic fatty liver disease (NAFLD). Metabolic syndrome occurs in ∼ 43% of women with PCOS, and NAFLD is the hepatic expression of MetS.

Methods:  One hundred women, 50 with PCOS and 50 controls, matched by age (18-35 years) and body mass index (BMI) were included, restricted to patients with overweight and obesity grade 1, at the Assis Chateaubrian Maternity School, Universidade Federal do Ceará, Brazil. Read More

Front Oncol 2022 27;12:650797. Epub 2022 Apr 27.

Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objectives: To investigate the feasibility of computer-aided discriminative diagnosis among hepatocellular carcinoma (HCC), hepatic metastasis, hepatic hemangioma, hepatic cysts, hepatic adenoma, and hepatic focal nodular hyperplasia, based on radiomics analysis of unenhanced CT images.

Methods: 452 patients with 77 with HCC, 104 with hepatic metastases, 126 with hepatic hemangioma, 99 with hepatic cysts, 24 with FNH, 22 with HA, who underwent CT examination from 2016 to 2018, were included. Radcloud Platform was used to extract radiomics features from manual delineation on unenhanced CT images. Read More

Transl Cancer Res 2022 Apr;11(4):935-942

Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: The liver cyst is commonly treated by hepatobiliary surgery. Generally, most patients show no apparent symptoms and often get diagnosed accidentally during the imaging examinations. In addition, most patients with liver cysts follow a benign course, with fewer severe complications and rare occurrences of malignant changes. Read More

Radiol Case Rep 2022 Jul 6;17(7):2394-2399. Epub 2022 May 6.

University Clinic for Surgery "Sv. Naum Ohridski", Skopje, North Macedonia.

The worldwide distribution of Echinococcus granulosus and its capability to persist in the human organism by causing serious medical and economical damage makes this parasite popular in terms of diagnosis and treatment implementation. Besides the liver as the primary target organ for this parasite, cases of secondary peritoneal hydatidosis are reported. Although rarely, they present with unusual abdominal symptoms with a bizarre presentation on abdominal ultrasound and Computerized Tomography scans. Read More

Nat Rev Gastroenterol Hepatol 2022 May 13. Epub 2022 May 13.

Department of Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute-Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.

Polycystic liver diseases (PLDs) are inherited genetic disorders characterized by progressive development of intrahepatic, fluid-filled biliary cysts (more than ten), which constitute the main cause of morbidity and markedly affect the quality of life. Liver cysts arise in patients with autosomal dominant PLD (ADPLD) or in co-occurrence with renal cysts in patients with autosomal dominant or autosomal recessive polycystic kidney disease (ADPKD and ARPKD, respectively). Hepatic cystogenesis is a heterogeneous process, with several risk factors increasing the odds of developing larger cysts. Read More

Diagn Interv Radiol 2022 Mar;28(2):149-155

Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Funabashi, Wadanaka-cho, Japan.

PURPOSE We retrospectively evaluated the efficacy of percutaneous sclerotherapy using a 4 F catheter and 40 mL of 5% ethanolamine oleate (EO) for symptomatic large hepatic cysts. METHODS Twenty-four patients, including 10 with polycystic liver disease (PLD), were eligible. The mean long- and short-axis diameters of the cyst on computed tomography (CT) were 145. Read More

Case Rep Gastroenterol 2022 Jan-Apr;16(1):201-208. Epub 2022 Mar 31.

Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Botucatu, Brazil.

Autosomal dominant polycystic liver disease (ADPLD) is a rare disease with variable clinical presentations, characterized by cystic enlargement of the liver. The diagnosis is made based on family history, patient's age, and liver phenotype and is confirmed by imaging tests. The treatment aims to reduce symptoms caused by the increased liver volume and can be performed by aspiration with sclerotherapy, fenestration, and liver resection. Read More

Surg Case Rep 2022 May 6;8(1):87. Epub 2022 May 6.

Division of Gastroenterological Surgery, Department of Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.

Background: Simple hepatic cysts are common lesions in adults, but rare in children. Because of their benign nature, simple hepatic cysts may not be detected until they grow too large to be diagnosed and resected in a minimally invasive manner.

Case Presentation: An 18-month-old girl presented with an enormous cyst occupying the entire abdomen. Read More

Asian J Surg 2022 Apr 30. Epub 2022 Apr 30.

Department of General Surgery, People's Hospital of Tibet Autonomous Region, Lhasa, 850000, China. Electronic address:

Zhonghua Yi Xue Za Zhi 2022 May;102(17):1303-1310

School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou 325000, China.

To establish a diagnostic model for alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) by combining multiple laboratory hematological indicators and explore its clinical diagnostic efficiency. A total of 124 inpatients, including 110 males and 14 females, aged 57 (51, 66) years, who were first diagnosed with AFP-NHCC in the PLA General Hospital were included from December 2011 to June 2017. Meanwhile, 331 cases of non-HCC were enrolled as the control group, including 279 males and 52 females, aged 58 (51, 63) years old, with 47 cases of hepatitis B virus (HBV) infection, 40 cases of liver cirrhosis, 64 cases of hepatic hemangioma or cysts, 7 cases of liver nodules, 8 cases of fatty liver, 146 cases of non-liver disease and 19 health controls. Read More

Ann Ital Chir 2022 ;93:224-228

Hepatic cysts have become increasingly frequent findings thanks to the improvement in diagnostic investigations. Distinction has to be made between congenital hepatic cysts (like liver cyst, PLCD) and acquired forms (such as a parasitic cyst and a cyst occurring as part of a neoplastic process) (1). When a simple hepatic cyst becomes symptomatic, when its size is > 4 cm or when there is some radiological suspicion of malignancy (thick wall, peripheral enhancement on CT/MRI) surgical management is indicated and relies on a variety of techniques (2). Read More

Int J Surg Pathol 2022 Apr 24:10668969221095263. Epub 2022 Apr 24.

Department of Hepato-Pancreato-Biliary Surgery, 6397Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

. Ciliated hepatic foregut cysts (CHFCs) are uncommon cystic lesions within the liver. CHFCs can undergo a malignant transformation to form a primary squamous cell carcinoma of the liver. Read More

Int J Surg Case Rep 2022 May 7;94:107036. Epub 2022 Apr 7.

Institute of Surgery, St. Luke's Medical Center, Manila, Philippines. Electronic address:

Introduction: Hydatidosis is an uncommon zoonotic infection in the Philippines with only a few reported cases. It frequently presents as benign liver cysts with variable symptoms often related to mass effect.

Case Presentation: We present a 49-year-old male with a significant travel history from East and Central Asia, surgically treated twice as a benign liver cyst and now presenting with recurrent multiple intraabdominal cysts. Read More

Acta Trop 2022 Aug 20;232:106466. Epub 2022 Apr 20.

Universidad de Extremadura. Facultad de Medicina y Ciencias de la Salud. Avda. de Elvas sn. 06006. Badajoz. España; Hospital Universitario de Badajoz. Servicio de Cirugía Hepatobiliopancreática y Trasplante Hepático. Avda. Elvas sn. 06080 Badajoz. España. Electronic address:

Background: Cystic echinococcosis is a clinically complex chronic parasitic disease and a major socioeconomic problem in endemic areas. The safety of liver resection in elderly patients is often debated among medical professionals. We analyzed the postoperative morbidity and mortality rates of elderly patients who underwent surgery at our unit. Read More

J Med Life 2022 Mar;15(3):374-378

Department of Pharmacology and Toxicology, College of Pharmacy, University of Kirkuk, Kirkuk, Iraq.

Echinococcosis is a parasitic infestation with high prevalence in Iraq. Surgical treatment remains the standard gold method for treating this disease. The selection of surgical approach depends on the general condition of the patient and characters of the cyst, , size, location, number of cysts, intraoperative findings, and complications such as adhesion, bile leakage, and bleeding. Read More

Medicines (Basel) 2022 Mar 29;9(4). Epub 2022 Mar 29.

Department of Gastroenterological Endoscopy, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Kahoku 920-0293, Ishikawa, Japan.

We report a novel missense mutation, p.Ile424Ser, in the gene of an autosomal dominant polycystic kidney disease (ADPKD) patient with multiple liver cysts. A 57-year-old woman presented to our university hospital with abdominal fullness, decreasing appetite, and dyspnea for three months. Read More