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Int J Infect Dis 2021 Jun 6. Epub 2021 Jun 6.

Department of Liver & Laparoscopic Surgery, Digestive & Vascular Surgery Center, 1(st)Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China; State Key Laboratory of Pathogenesis, Prevention, Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi 830054, China. Electronic address:

Objectives: We aimed to investigate the potential biomarker for distinguishing biological viability of hepatic echinococcosis.

Methods: We measured plasma concentrations of several cytokines and chemokines in patients with active and non-active cysts (HCE, n = 47), stable/progressive alveolar echinococcosis (HAE, n = 38) patients and their comparable infection-free volunteers (n = 48) through Luminex assay technique. Disease progression was staged according to the classification standard. Read More

Case Rep Surg 2021 21;2021:9977326. Epub 2021 May 21.

Department of General and Digestive Surgery A at the University Hospital Charles Nicolle, University of Tunis el Manar, Tunisia.

Hydatidosis is a widespread anthropozoonosis. It can affect almost any part of the body, but it occurs most commonly in the liver (75%) and the lungs (15%). Its occurrence in female genital tract, especially the uterus, is very rare. Read More

BMC Pediatr 2021 06 5;21(1):265. Epub 2021 Jun 5.

Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuou-ku, 330-8777, Saitama, Japan.

Background: Spontaneous infection of preexisting solitary renal cysts has been documented in adults but is extremely rare in children. To date, no cases of simple renal cysts infected with Streptococcus pneumoniae have been described. Recently, reports have described the diagnosis of bacterial infection using the 16 S rRNA gene as well as the accompanying antimicrobial stewardship for microorganisms that are difficult to culture and for culture-negative cases after preceding antibacterial administration. Read More

Surg Infect (Larchmt) 2021 Jun 2. Epub 2021 Jun 2.

Department of Thoracic Surgery, Mohammed V Military Teaching Hospital, Rabat, Morocco.

The association of pulmonary and hepatic hydatid cysts is rare. Managing this condition with low mortality and complications is a challenge. The aim of this study is to put forward our experience in managing both sites in single-stage posterolateral thoracotomy. Read More

Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):650-654

Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

To investigate the clinicopathologic characteristics of hepatic echinococcus granulosus (HEG). Thirteen cases of HEG were collected from Linzhi People's Hospital between January 2017 to October 2020, and their clinicopathologic features, ultrasound classification, immunophenotype and histochemical data were analyzed, retrospectively and the relevant literature was reviewed. Thirteen patients (5 male patients, 8 female patients) were included in this cohort, and the mean age was 40 years. Read More

Radiologe 2021 Jun 1. Epub 2021 Jun 1.

Klinische Abteilung für Kinderradiologie, Universitätsklinik für Radiologie, Medizinische Universität Graz, Auenbruggerplatz 34, 8036, Graz, Österreich.

Background: Pediatric liver tumors are relatively rare, but thorough knowledge of their imaging features is still important.

Objectives: Frequency and imaging features of benign and malignant liver masses during childhood and adolescence.

Materials And Methods: Discussion of relevant original articles, review manuscripts and expert recommendations concerning imaging of childhood liver tumors. Read More

J Med Case Rep 2021 May 28;15(1):311. Epub 2021 May 28.

Inflammatory Lung Disease Research Center, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran.

Background: Hydatid cysts are fluid-filled sacs containing immature forms of parastic tapeworms of the genus Echinococcus. The most prevalent and serious complication of hydatid disease is intrabiliary rupture, also known as cystobiliary fistulae. In this study, a sporadic case of biliary obstruction, cholangitis, and septicemia is described secondary to hydatid cyst rupture into the common bile duct and intraperitoneal cavity. Read More

Am J Surg Pathol 2021 May 27. Epub 2021 May 27.

Departments of Diagnostic Pathology Medical Oncology Hepatic and Pancreatobiliary Oncology Pediatric Oncology Head and Neck Medical Oncology Division Rare Cancer Center, National Cancer Center Hospital, Tokyo, Japan.

ATF1, CREB1, and CREM, which encode the CREB family of transcription factors, are fused with EWSR1 or FUS in human neoplasms, such as angiomatoid fibrous histiocytoma. EWSR1/FUS-CREB fusions have recently been reported in a group of malignant epithelioid tumors with a predilection to the peritoneal cavity and frequent cytokeratin expression. Here, we studied 8 cytokeratin-positive abdominal malignancies with these fusions for further characterization. Read More

J Vet Diagn Invest 2021 May 24:10406387211017107. Epub 2021 May 24.

North Carolina State University College of Veterinary Medicine, Raleigh, NC, USA.

Choledochal cysts, congenital segmental dilations of the common bile duct, have been reported in few cats, and histologic characterization is lacking. A 20-mo-old spayed female domestic shorthair cat was presented because of vomiting and weight loss. There was progressive elevation of liver enzyme activity (ALT > ALP, GGT) and hyperbilirubinemia. Read More

Front Med (Lausanne) 2021 5;8:574047. Epub 2021 May 5.

Hybrid Technology Hub-Center of Excellence, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to investigate development, toxicity, as well as genetic and infectious disease in ways currently limited by the availability of primary tissue. With the added advantage of patient specificity, which can play a role in all of these areas. Many iPSC differentiation protocols focus on 3 dimensional (3D) or organotypic differentiation, as these offer the advantage of more closely mimicking systems including; the formation of tissue like architecture and interactions/crosstalk between different cell types. Read More

J Hematol 2021 Apr 27;10(2):71-75. Epub 2021 Apr 27.

Division of Hematology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada.

We present a case of immune thrombocytopenic purpura (ITP), which leads to the diagnosis of severe cystic echinococcosis. Our patient presented with platelets of 5 × 10/L, and investigations uncovered multiple large echinococcal hepatic cysts, the largest of which measured 19.4 × 15 × 12 cm, and peritoneal implants. Read More

Pan Afr Med J 2021 22;38:195. Epub 2021 Feb 22.

Department of General and Digestive Surgery, Faculty of Medicine, University of Sfax, Habib Bourguiba Hospital, Sfax, Tunisia.

Introduction: the treatment of large biliocystic fistulas is not unanimous among authors in the absence of consensus or a high level of evidence. There is a controversy over the use of a radical approach which allows the fistula to be sutured in a healthy area or conservative treatment that poses repair issues. The purpose of this study is to compare different conservative techniques to treat large biliocystic fistulas. Read More

Pan Afr Med J 2021 18;38:188. Epub 2021 Feb 18.

Department of Pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.

Congenital hepatic fibrosis (CHF) is a rare autosomal recessive disease derived from biliary dysgenesis secondary to ductal plate malformation; it often coexists with Caroli's disease, von Meyenburg complexes, autosomal dominant polycystic kidney disease (ADPKD), and autosomal recessive polycystic kidney disease (ARPKD). Although CHF was first named and described in detail by Kerr et al. in 1961. Read More

Cardiovasc Intervent Radiol 2021 May 13. Epub 2021 May 13.

Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Purpose: Although hydatid liver cyst (HLC) is a benign disease, treatment is recommended to avoid life-threatening complications. There are several treatment options for HLC: "wait-and-watch," medical or surgical or percutaneous treatment. The purpose of this study was to assess the long-term effectiveness of an alternative of the traditional percutaneous PAIR procedure, called double percutaneous aspiration and ethanol injection (D-PAI). Read More

Microbiome 2021 05 6;9(1):101. Epub 2021 May 6.

Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200135, China.

Background: The characteristics of polycystic ovary syndrome (PCOS), a common reproductive endocrinal disorder, are high incidence, complicated aetiology and poor therapeutic effects. PCOS patients frequently exhibit gut dysbiosis; however, its roles in the regulation of metabolic and endocrinal balances in PCOS pathophysiology are not clear.

Results: In this study, gut dysbiosis was reproduced in dehydroepiandrosterone (DHEA)-induced PCOS-like rats. Read More

CEN Case Rep 2021 May 3. Epub 2021 May 3.

Department of Pediatrics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

The gene encoding hepatocyte nuclear factor 1β (HNF1B), a transcription factor involved in the development of the kidney and other organs, is located on chromosome 17q12. Heterozygous deletions of chromosome 17q12, which involve 15 genes including HNF1B, are known as 17q12 deletion syndrome and are a common cause of congenital anomalies of the kidneys and urinary tract (CAKUT) and may also present as a multisystem disorder. Autosomal recessive polycystic kidney disease (ARPKD), on the other hand, is a severe form of polycystic kidney disease caused by mutations in PKHD1 (polycystic kidney and hepatic disease 1). Read More

Clin Case Rep 2021 Apr 22;9(4):2483-2484. Epub 2021 Feb 22.

Department of Emergency and Critical Care Medicine The University of Tokyo Hospital Bunkyo-ku Japan.

Hepatic cysts usually do not cause symptoms and may be detected incidentally on abdominal imaging. However, a giant hepatic cyst can rarely compress the inferior vena cava, right lung, and spine, leading to edema of lower extremities and scoliosis. Read More

PLoS Negl Trop Dis 2021 Apr 28;15(4):e0009370. Epub 2021 Apr 28.

Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Salamanca, Spain.

Background: The diagnosis of cystic echinococcosis (CE) is primarily based on imaging, while serology should be applied when imaging is inconclusive. CE cyst stage has been reported among the most important factors influencing the outcome of serodiagnosis. We performed a systematic review and meta-analysis of the relation between cyst stage of hepatic CE and diagnostic sensitivity of serological tests, to evaluate whether their relation is a consistent finding and provide guidance for the interpretation of results of serological tests. Read More

J Pathol 2021 Jul 21;254(3):289-302. Epub 2021 May 21.

Department of Anatomy and Cell Biology, The Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, KS, USA.

Polycystic liver disease (PLD) is characterized by the growth of numerous biliary cysts and presents in patients with autosomal dominant polycystic kidney disease (ADPKD), causing significant morbidity. Interestingly, deletion of intraflagellar transport-B (IFT-B) complex genes in adult mouse models of ADPKD attenuates the severity of PKD and PLD. Here we examine the role of deletion of an IFT-A gene, Thm1, in PLD of juvenile and adult Pkd2 conditional knockout mice. Read More

Parasite Immunol 2021 Jul 4;43(7):e12839. Epub 2021 May 4.

State Key Laboratory of Pathogenesis, Prevention and Management of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Aims: The study aimed to investigate possible correlation between expression level of Th1/Th2/Th17-type profile and cyst viability in the systemic and local immunity of hepatic cystic Echinococcosis (CE) patients.

Methods And Results: Expression of Th1-type interleukin (IL)-2, interferon (IFN)-γ, tumour necrosis factor (TNF)-α, Th2-type IL-4, IL-6, IL-10 and Th17-type IL-17A was examined in the serum and liver samples of hepatic CE patients with different cyst stages. Compared with healthy controls, Th1/Th2/Th17-type cytokines were significantly increased in the serum of hepatic CE patients. Read More

Cureus 2021 Mar 17;13(3):e13957. Epub 2021 Mar 17.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Background Laparoscopic closed cystectomy of the hepatic hydatid cyst (HHC) is increasingly being performed as it has improved postoperative recovery and reduced morbidity. However, laparoscopic closed cystectomy of HHC is difficult when located in segments VI, VII, and VIII. This study aimed to assess the laparoscopic closed cystectomy feasibility of the HHC when cysts are located at the difficult access site. Read More

Pediatr Dev Pathol 2021 Apr 19:10935266211008443. Epub 2021 Apr 19.

Department of Pathology and Laboratory Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

DICER1 tumor predisposition syndrome is a rare genetic disorder that predisposes individuals to multiple benign and malignant neoplasms. The phenotype is vast and includes pleuropulmonary blastoma (PPB), thyroid nodules, cystic nephroma, Wilms tumor, ovarian Sertoli-Leydig cell tumor, and medulloepithelioma, among others. Herein, we describe a patient with a germline pathogenic variant presenting with two neoplasms that are not commonly encountered in the context of DICER1 syndrome. Read More

Clin J Gastroenterol 2021 Jun 13;14(3):888-892. Epub 2021 Apr 13.

Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University Hospital of Pavia, Pavia, Italy.

Therapy choices for cystic echinococcisis (CE) are stage-specific: surgical, minimally invasive, medical or observation without intervention. PAIR (percutaneous aspiration, instillation of a scolicide, and re-aspiration) has been considered the treatment of choice for uncomplicated echinococcal liver cysts. However, PAIR carries the risk of toxic cholangitis or hypernatremia and that the cyst frequently refills with bile after withdrawing the catheter. Read More

Parasit Vectors 2021 Apr 12;14(1):197. Epub 2021 Apr 12.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Cystic echinococcosis (CE) is a disease caused by the larval stage of Echinococcus granulosus sensu lato  (s.l.). Read More

Transl Gastroenterol Hepatol 2021 5;6:26. Epub 2021 Apr 5.

Liver Center and Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Fibrocystic liver diseases (FLDs) comprise a heterogeneous group of rare diseases of the biliary tree, having in common an abnormal development of the embryonic ductal plate caused by genetically-determined dysfunctions of proteins expressed in the primary cilia of cholangiocytes (and therefore grouped among the "ciliopathies"). The ductal dysgenesis may affect the biliary system at multiple levels, from the small intrahepatic bile ducts [congenital hepatic fibrosis (CHF)], to the larger intrahepatic bile ducts [Caroli disease (CD), or Caroli syndrome (CS), when CD coexists with CHF], leading to biliary microhamartomas and segmental bile duct dilations. Biliary changes are accompanied by progressive deposition of abundant peribiliary fibrosis. Read More

Case Rep Gastroenterol 2021 Jan-Apr;15(1):244-252. Epub 2021 Feb 26.

Department of Surgery, Dr. Hedgewar Arogya Sansthan, Delhi, India.

Giant biliary calculus in the common bile duct (CBD) is rare. Giant calculus of choledochal cyst (CC) is even rarer, and no case of giant calculus of CC with more than 100 calculi has been reported in the indexed literature. We present the case of a 8. Read More

Asian J Surg 2021 May 28;44(5):784-785. Epub 2021 Mar 28.

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, 244280, Malatya, Turkey.

Clin Case Rep 2021 Mar 21;9(3):1115-1117. Epub 2021 Jan 21.

Faculté de Médecine de Tunis Université de Tunis El Manar Tunis Tunisia.

Hydatid disease is a major health problem. Multiorgan involvement including the heart and the liver is a very rare presentation. Management of multivisceral hydatidosis through a sole incision should be considered when possible. Read More

J Parasit Dis 2021 Mar 3;45(1):236-243. Epub 2020 Nov 3.

Department of Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Cystic echinococcosis (CE) is a severe neglected zoonotic parasitic disease caused by the larval stage of the dog tapeworm, . The objectives of this study were to determine the prevalence of hydatid cysts in dromedary camels () at Sharkia province, Egypt and investigate the occurrence of bacteria in hydatid fluid. A total of 6416 dromedary camels slaughtered in five abattoirs in Sharkia province, Egypt during the period from January and December 2018 were investigated for the presence of hydatid cysts. Read More

J Parasit Dis 2021 Mar 26;45(1):197-203. Epub 2020 Oct 26.

Department of Microbiology and Parasitology, The Persian Gulf Tropical and Infectious Diseases Research Center, Bushehr University of Medical Sciences, Salman Farsi St, Bushehr, Iran.

Hydatid cyst is one of the parasitic zoonoses caused by infection with the larval stage of tapeworm. The spread of this parasite is global and is of great importance in terms of public health. To date, ten different species of this parasite have been identified that differ in characteristics such as life cycle, epidemiology and pathogenesis. Read More